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[PMID]: 29433389
[Au] Autor:Jang E; Inn KS; Jang YP; Lee KT; Lee JH
[Ad] Address:* College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
[Ti] Title:Phytotherapeutic Activities of Sanguisorba officinalis and its Chemical Constituents: A Review.
[So] Source:Am J Chin Med;:1-20, 2018 Feb 12.
[Is] ISSN:0192-415X
[Cp] Country of publication:Singapore
[La] Language:eng
[Ab] Abstract:Sanguisorba officinalis Linne (S. officinalis, Rosaceae) has been used as a medicinal plant for the treatment of burns, hematemesis, melena, intestinal infections, and dermatitis for a long time in China, Korea, and Japan. The therapeutic efficacy of this herb is intimately associated with its anti-oxidant, anti-inflammatory, antiviral, antifungal, hemostatic, and anticancer activities. Its root contains triterpenoid saponins (zigyuglycoside I: C[Formula: see text]H[Formula: see text]O[Formula: see text] and ziyuglycoside II: C[Formula: see text]H[Formula: see text]O ) and tannins (sanguiin H-6: C[Formula: see text]H[Formula: see text]O[Formula: see text]). It has been recently revealed that these active constituents of S. officinalis possess antiwrinkle properties without cytotoxicity. They also have anticancer effects by inducing apoptosis and cell cycle arrest. Moreover, they can inhibit proliferative tumorigenesis. The underlying mechanism involved in the pharmacological actions of these active constituents is mainly related to p38 MAPK signaling. Although various studies have reported its therapeutic activities and major chemical components, review articles that extensively organize various properties of S. officinalis and its major constituents are still scarce. Taken together, the objective of this paper is to provide overall pharmacological and phytochemical profiles of S. officinalis and its constituents (including ziyuglycoside I, ziyuglycoside II, and sanguiin H-6), and their potential roles in clinical applications for the treatment of inflammatory diseases, bleeding disorders, and cancer.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[St] Status:Publisher
[do] DOI:10.1142/S0192415X18500155

  2 / 118 MEDLINE  
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[PMID]: 29425875
[Au] Autor:Zhang H; Chen J; Cen Y
[Ad] Address:Department of Burn and Plastic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
[Ti] Title:Burn wound healing potential of a polysaccharide from Sanguisorba officinalis L. in mice.
[So] Source:Int J Biol Macromol;, 2018 Feb 06.
[Is] ISSN:1879-0003
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Sanguisorba officinalis L. is widely used in China to treat various wounds, particularly burns. The present study was carried to evaluate the healing efficacy of a purified polysaccharide (SOP) from the roots of S. officinalis L. on burn wound models in mice. The results indicated that oral administration of SOP (50 and 200 mg/kg) significantly stimulated wound contraction and reduced epithelialization time as compared to control group, which might be mediated by promoting collagen synthesis as evidenced by an increase of hydroxyproline content. Elevation of IL-1ß and VEGF content was also observed in mice following SOP treatment, which in turn facilitate epithelization and angiogenesis. Besides, histopathological examination of the wound tissues in the SOP-treated animals showed collagen deposition and epidermal formation. It may be concluded that the enhancement of burn wound healing by SOP might be due to promotional collagen synthesis and angiogenesis during skin wound repair as a result of the stimulation of hydroxyproline, IL-1ß and VEGF production. The excellent wound-healing activities of SOP provide a scientific rationale for the development of plant-based product in the management of wounds.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180209
[Lr] Last revision date:180209
[St] Status:Publisher

  3 / 118 MEDLINE  
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[PMID]: 29399737
[Au] Autor:Fry EL; Johnson GN; Hall AL; Pritchard WJ; Bullock JM; Bardgett RD
[Ad] Address:School of Earth and Environmental Sciences, Michael Smith Building, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK. Ellen.fry@manchester.ac.uk.
[Ti] Title:Drought neutralises plant-soil feedback of two mesic grassland forbs.
[So] Source:Oecologia;, 2018 Feb 05.
[Is] ISSN:1432-1939
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Plant-soil feedbacks (PSFs) describe the effect of a plant species on soil properties, which affect the performance of future generations. Here we test the hypothesis that drought alters PSFs by reducing plant-microbe associations and nutrient uptake. We chose two grassland forb species, previously shown to respond differently to soil conditioning and drought, to test our hypothesis. We conditioned unsterilised grassland soil with one generation of each species, and left a third soil unconditioned. We grew a second generation consisting of each combination of plant species, soil, and drought in a full factorial design, and measured soil microbial community and nutrient availability. Scabiosa columbaria displayed negative PSF (smaller plants) under non-droughted conditions, but neutral under drought, suggesting that drought disrupts plant-soil interactions and can advantage the plant. Photosynthetic efficiency of S. columbaria was reduced under drought, but recovered on rewetting regardless of soil conditioning, indicating that PSFs do not impede resilience of this species. Sanguisorba minor showed positive PSFs (larger plants), probably due to an increase in soil N in conspecific soil, but neutral PSF under drought. PSF neutralisation appeared to occur through drought-induced change in the soil microbial community for this species. When S. minor was planted in conspecific soil, photosynthetic efficiency declined to almost zero, with no recovery following rewetting. We attributed this to increased demand for water through higher demand for nutrients with positive PSF. Here we show that drought neutralises PSFs of two grassland forbs, which could have implications for plant communities under climate change.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180205
[Lr] Last revision date:180205
[St] Status:Publisher
[do] DOI:10.1007/s00442-018-4082-x

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[PMID]: 29193282
[Au] Autor:Seo DW; Cho YI; Gu S; Kim DH; Yi YJ; Lee SM
[Ad] Address:Gyeongbuk Institute for Bio industry, Andong-si, Gyeongbuk 760-380, South Korea.
[Ti] Title:A hot-water extract of Sanguisorba officinalis ameliorates endotoxin-induced septic shock by inhibiting inflammasome activation.
[So] Source:Microbiol Immunol;62(1):44-54, 2018 Jan.
[Is] ISSN:1348-0421
[Cp] Country of publication:Australia
[La] Language:eng
[Ab] Abstract:The inflammasome is a multiprotein signaling complex that mediates inflammatory innate immune responses through caspase 1 activation and subsequent IL-1ß secretion. However, because its aberrant activation often leads to inflammatory diseases, targeting the inflammasome holds promise for the treatment of inflammation-related diseases. In this study, it was found that a hot-water extract of Sanguisorba officinalis (HSO) suppresses inflammasome activation triggered by adenosine 5'-triphosphate, nigericin, microbial pathogens, and double stranded DNA in bone marrow-derived macrophages. HSO was found to significantly suppress IL-1ß production in a dose-dependent manner; this effect correlated well with small amounts of caspase 1 and little ASC pyroptosome formation in HSO-treated cells. The anti-inflammatory activity of HSO was further confirmed in a mouse model of endotoxin-induced septic shock. Oral administration of HSO reduced IL-1ß titers in the serum and peritoneal cavity, increasing the survival rate. Taken together, our results suggest that HSO is an inhibits inflammasome activation through nucleotide-binding domain and leucine-rich repeat pyrin domain 3, nucleotide-binding domain and leucine-rich repeat caspase recruitment domain 4 and absent in melanoma 2 pathways, and may be useful for treatment of inflammasome-mediated diseases.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180111
[Lr] Last revision date:180111
[St] Status:In-Process
[do] DOI:10.1111/1348-0421.12557

  5 / 118 MEDLINE  
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[PMID]: 29115041
[Au] Autor:Sliwinska EB; Martyka R; Martyka M; Cichon M; Tryjanowski P
[Ad] Address:Institute of Nature Conservation, Polish Academy of Sciences, Mickiewicza 33, 31-120, Kraków, Poland.
[Ti] Title:A biotrophic fungal infection of the great burnet Sanguisorba officinalis indirectly affects caterpillar performance of the endangered scarce large blue butterfly Phengaris teleius.
[So] Source:Insect Sci;, 2017 Nov 07.
[Is] ISSN:1744-7917
[Cp] Country of publication:Australia
[La] Language:eng
[Ab] Abstract:Interactions between ecological communities of herbivores and microbes are commonly mediated by a shared plant. A tripartite interaction between a pathogenic fungus-host plant-herbivorous insect is an example of such mutual influences. In such a system a fungal pathogen commonly has a negative influence on the morphology and biochemistry of the host plant, with consequences for insect herbivore performance. Here we studied whether the biotrophic fungus Podosphaera ferruginea, attacking the great burnet Sanguisorba officinalis, affects caterpillar performance of the endangered scarce large blue butterfly Phengaris teleius. Our results showed that the pathogenic fungus affected the number and size of inflorescences produced by food-plants and, more importantly, had indirect, plant-mediated effects on the abundance, body mass and immune response of caterpillars. Specifically, we found the relationship between caterpillar abundance and variability in inflorescence size on a plant to be positive among healthy food-plants, and negative among infected food-plants. Caterpillars that fed on healthy food-plants were smaller than those that fed on infected food-plants in one studied season, while there was no such difference in the other season. We observed the relationship between caterpillar immune response and the proportion of infected great burnets within a habitat patch to be positive when caterpillars fed on healthy food-plants, and negative when caterpillars fed on infected food-plants. Our results suggest that this biotrophic fungal infection of the great burnet may impose a significant indirect influence on P. teleius caterpillar performance with potential consequences for the population dynamics and structure of this endangered butterfly. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171108
[Lr] Last revision date:171108
[St] Status:Publisher
[do] DOI:10.1111/1744-7917.12556

  6 / 118 MEDLINE  
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[PMID]: 28960612
[Au] Autor:Zhu X; Wang K; Yao Y; Zhang K; Zhou F; Zhu L
[Ad] Address:Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, Jiangsu Province, People's Republic of China.
[Ti] Title:Triggering p53 activation is essential in ziyuglycoside I-induced human retinoblastoma WERI-Rb-1 cell apoptosis.
[So] Source:J Biochem Mol Toxicol;, 2017 Sep 28.
[Is] ISSN:1099-0461
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Ziyuglycoside I (Ziyu I), one of the major components isolated from the root of Sanguisorba officinalis L., has been proved for the antitumor properties on oral cancer, prostate cancer, and colorectal cancer. However, the effect of Ziyu I on retinoblastoma (RB) is not well understood. In this study, we investigated the inhibitory effect and underlying molecular mechanism of Ziyu I on human RB WERI-Rb-1 cells. Our results indicated that Ziyu I could suppress cell viability and induce mitochondrial-dependent cell apoptosis in WERI-Rb-1 cells. Furthermore, Ziyu I treatment increased p53 expression as well as improved p53 stabilization through downregulation of pS166-Mdm2 and upregulation of phosphorylated- and acetylated-p53. Blockade of p53 significantly attenuated Ziyu I-induced mitochondrial dysfunction. Our findings demonstrate that Ziyu I exhibits excellent anticancer effect on human RB WERI-Rb-1 cells by triggering p53 activation, and imply Ziyu I as a potential compound for chemotherapy of human RB.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170929
[Lr] Last revision date:170929
[St] Status:Publisher
[do] DOI:10.1002/jbt.22001

  7 / 118 MEDLINE  
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[PMID]: 28832233
[Au] Autor:Im SH; Wang Z; Lim SS; Lee OH; Kang IJ
[Ad] Address:a Department of Food Science and Nutrition , Hallym University , Chuncheon , Republic of Korea.
[Ti] Title:Bioactivity-guided isolation and identification of anti-adipogenic compounds from Sanguisorba officinalis.
[So] Source:Pharm Biol;55(1):2057-2064, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:CONTEXT: Sanguisorba officinalis Linne (Rosaceae) is a medicinal plant used traditionally for the treatment of inflammatory and metabolic diseases in Korea, China, and Japan. In our previous study, a 50% ethanol extract inhibited fat accumulation in 3T3-L1 adipocytes. OBJECTIVE: This study investigates bioassay-guided fractionation, isolation, and identification of anti-adipogenic bioactive compounds in S. officinalis. MATERIALS AND METHODS: The bioassay-guided fractionation was conducted using effective differentiation of 3T3-L1 cells into adipocytes (with 50 µg/mL test material for 8 days) to isolate the inhibitory compounds from ethyl acetate fraction of S. officinalis 50% ethanol extract. The cytotoxicity of each fraction and isolated compound was tested using MTT assay (with 25-300 µg/mL test material). Structures of the isolated active compounds were elucidated using H NMR, C NMR, HSQC, HMBC, FT-IR, and MS. RESULTS: An active ethyl acetate fraction obtained with solvent partition of the extract inhibited lipid accumulation (44.84%) on 3T3-L1 cells without cytotoxicity (102.3%) at the concentration of 50 µg/mL. The ethyl acetate fraction was determined to be mainly composed by isorhamnetin-3-O-d-glucuronide (1) and ellagic acid (2). Pure isorhamnetin-3-O-d-glucuronide (IC is 18.43 µM) and ellagic acid (IC is 19.32 µM) showed lipid accumulation inhibition on 3T3-L1 cells without cytotoxicity (117.5% and 104.3%) at the concentration of 20 µM, respectively. DISCUSSION AND CONCLUSIONS: These results suggested that S. officinalis is a potential natural ingredient for the prevention of obesity, which may due to bioactive compounds such as isorhamnetin-3-O-d-glucuronide and ellagic acid.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170823
[Lr] Last revision date:170823
[St] Status:In-Process
[do] DOI:10.1080/13880209.2017.1357736

  8 / 118 MEDLINE  
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[PMID]: 28718964
[Au] Autor:Nam SH; Lkhagvasuren K; Seo HW; Kim JK
[Ad] Address:Department of Biomedical Science, Catholic University of Daegu, Gyeongsan-si, 38430, Korea.
[Ti] Title:Antiangiogenic Effects of Ziyuglycoside II, a Major Active Compound of Sanguisorba officinalis L.
[So] Source:Phytother Res;31(9):1449-1456, 2017 Sep.
[Is] ISSN:1099-1573
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Ziyuglycoside II, a major bioactive compound of Sanguisorba officinalis L., displays anticancer potential against several human cancer cells. However, little information concerning its antiangiogenic properties and possible mechanisms is available. The aim of this study was to investigate the inhibitory effects of ziyuglycoside II on angiogenesis. Ziyuglycoside II inhibited the proliferation, migration, and tubule formation of human umbilical vein endothelial cells, as well as the number of microvessels growing from the aortic rings. The underlying antiangiogenic mechanism of ziyuglycoside II correlated with blocking vascular endothelial growth factor receptor-2 and the fibroblast growth factor receptor-1 mediated signaling pathway. Moreover, an in vivo Matrigel plug assay in mice showed a significant decrease in vascularization and hemoglobin content in the plugs from ziyuglycoside II-treated mice compared with control mice. Overall, these results suggest that ziyuglycoside II inhibits various attributes of angiogenesis, which might contribute to its reported antitumor effects. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] MeSH terms primary: Angiogenesis Inhibitors/pharmacology
Neovascularization, Pathologic/drug therapy
Sanguisorba/chemistry
Saponins/pharmacology
[Mh] MeSH terms secundary: Animals
Aorta/drug effects
Human Umbilical Vein Endothelial Cells/drug effects
Humans
In Vitro Techniques
Male
Mice
Mice, Inbred C57BL
Rats, Sprague-Dawley
Receptor, Fibroblast Growth Factor, Type 1/metabolism
Signal Transduction/drug effects
Vascular Endothelial Growth Factor Receptor-2/metabolism
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Angiogenesis Inhibitors); 0 (Saponins); 0 (ziyuglycoside II); EC 2.7.10.1 (Receptor, Fibroblast Growth Factor, Type 1); EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-2)
[Em] Entry month:1710
[Cu] Class update date: 171010
[Lr] Last revision date:171010
[Js] Journal subset:IM
[Da] Date of entry for processing:170719
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5874

  9 / 118 MEDLINE  
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[PMID]: 28475935
[Au] Autor:Szejk M; Poplawski T; Czubatka-Bienkowska A; Olejnik AK; Pawlaczyk-Graja I; Gancarz R; Zbikowska HM
[Ad] Address:Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
[Ti] Title:A comparative study on the radioprotective potential of the polyphenolic glycoconjugates from medicinal plants of Rosaceae and Asteraceae families versus their aglycones.
[So] Source:J Photochem Photobiol B;171:50-57, 2017 Jun.
[Is] ISSN:1873-2682
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Radioprotective potential of the polyphenolic glycoconjugates, isolated from flowers of Sanguisorba officinalis L. (So) and Erigeron canadensis L. (Ec), and from leaves of Fragaria vesca L. (Fv) and Rubus plicatus Whe. Et N. E. (Rp) as well as their aglycones (SoA, EcA, FvA and RpA, respectively), against γ-radiation-induced lipid peroxidation in human plasma and DNA damage in lymphocytes, were investigated in vitro. These properties were assessed by measuring the concentration of thiobarbituric acid reactive substances (TBARS) and using the alkaline comet assay, and were compared to the protective effects of rutin (R) and quercetin (Q). Cytotoxicity of the glycoconjugates/aglycones towards L929 mouse fibroblasts and human lymphocytes were also measured. Plant products from S. officinalis, similar to Q, were able to reduce the most radiation-induced lipid peroxidation as well as DNA damage and extent of oxidative damage to the DNA basis. Contrary to the pure flavonoids, where Q was shown to be significantly more effective than its glycoside R, the results did not show more benefit with application of SoA/EcA over So/Ec in terms of lipid peroxidation inhibition. Moreover, glycoconjugates Ec and So showed much higher capacity in protecting lymphocytes against radiation-induced genotoxicity which may suggest that between the polyphenolic and polysaccharide parts exist some synergistic effects. There were no significant differences between Fv versus FvA or Rp versus RpA in terms of the provided radioprotection. Summarizing, plant glycoconjugates isolated by the multi-step method offered sufficient radioprotection. In addition, they possess many advantages, compared to the synthetic polyphenolic compounds or the plant extracts, such as water-solubility and minor toxicity.
[Mh] MeSH terms primary: Glycoconjugates/chemistry
Polyphenols/chemistry
Radiation-Protective Agents/pharmacology
Rosaceae/chemistry
[Mh] MeSH terms secundary: Animals
Antioxidants/chemistry
Asteraceae/chemistry
Asteraceae/metabolism
Cell Line
Cell Survival/drug effects
Cell Survival/radiation effects
Comet Assay
DNA/chemistry
DNA/metabolism
DNA Damage/drug effects
DNA Damage/radiation effects
Gamma Rays
Glycoconjugates/isolation & purification
Glycoconjugates/pharmacology
Humans
Lipid Peroxidation/drug effects
Lipid Peroxidation/radiation effects
Mice
Plants, Medicinal/chemistry
Plants, Medicinal/metabolism
Quercetin/pharmacology
Radiation-Protective Agents/chemistry
Radiation-Protective Agents/isolation & purification
Rosaceae/metabolism
Rutin/pharmacology
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antioxidants); 0 (Glycoconjugates); 0 (Polyphenols); 0 (Radiation-Protective Agents); 5G06TVY3R7 (Rutin); 9007-49-2 (DNA); 9IKM0I5T1E (Quercetin)
[Em] Entry month:1709
[Cu] Class update date: 170920
[Lr] Last revision date:170920
[Js] Journal subset:IM
[Da] Date of entry for processing:170506
[St] Status:MEDLINE

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[PMID]: 28387987
[Au] Autor:Tausch S; Leipold M; Poschlod P; Reisch C
[Ad] Address:University of Regensburg, Institute of Plant Sciences, Regensburg, Germany.
[Ti] Title:Molecular markers provide evidence for a broad-fronted recolonisation of the widespread calcareous grassland species Sanguisorba minor from southern and cryptic northern refugia.
[So] Source:Plant Biol (Stuttg);19(4):562-570, 2017 Jul.
[Is] ISSN:1438-8677
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Calcareous grasslands belong to the most species-rich and endangered habitats in Europe. However, little is known about the origin of the species typically occurring in these grasslands. In this study we analysed the glacial and post-glacial history of Sanguisorba minor, a typical plant species frequently occurring in calcareous grasslands. The study comprised 38 populations throughout the whole distribution range of the species across Europe. We used molecular markers (AFLP) and applied Bayesian cluster analysis as well as spatial principal components analysis (sPCA) to identify glacial refugia and post-glacial migration routes to Central Europe. Our study revealed significant differences in the level of genetic variation and the occurrence of rare fragments within populations of S. minor and a distinct separation of eastern and western lineages. The analyses uncovered traditional southern but also cryptic northern refugia and point towards a broad fronted post-glacial recolonisation. Based on these results we postulate that incomplete lineage sorting may have contributed to the detected pattern of genetic variation and that S. minor recolonised Central Europe post-glacially from Iberia and northern glacial refugia in France, Belgium or Germany. Our results highlight the importance of refugial areas for the conservation of intraspecific variation in calcareous grassland species.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1704
[Cu] Class update date: 170616
[Lr] Last revision date:170616
[St] Status:In-Process
[do] DOI:10.1111/plb.12570


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