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[PMID]: 29501622
[Au] Autor:Yan YT; Li SD; Li C; Xiong YX; Lu XH; Zhou XF; Yang LQ; Pu LJ; Luo HY
[Ad] Address:Department of Pharmacology, College of Basic Medicine, Kunming Medical University, Kunming, Yunnan, PR China.
[Ti] Title:Panax notoginsenoside saponins Rb1 regulates the expressions of Akt/ mTOR/PTEN signals in the hippocampus after focal cerebral ischemia in rats.
[So] Source:Behav Brain Res;345:83-92, 2018 Mar 05.
[Is] ISSN:1872-7549
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Panax notoginsenoside saponins Rb1 (PNS-Rb1) is an important active ingredient of panax notoginseng for effective treatment of cerebrovascular diseases. However, the mechanism underlying its actions in the state of cerebral ischemia is still unclear. We asked whether the potential neuroprotection of PNS-Rb1 on the brain is due to, at least partially, its modulation of AkT/mTOR/PTEN signalling pathway along with down-regulation of caspase-3 in rats subjected to phototrombic stroke. To test this hypothesis, rats with induced photothrombotic stroke were treated with PNS-Rb1 (applied in three different doses, 25 mg/kg, 50 mg/kg,100 mg/kg, respectively) or saline, while sham operated rats injected with saline were used as the control. Our results indicate that PNS-Rb1 significantly alleviated the morphological lesion concomitant with improvement of cognitive and sensorimotor deficits induced by ischemic stroke. Moreover, immunohistochemistry and Western blot analyses showed that PNS Rb1 in a dose dependent manner increased the expressions of P-Akt, P-mTOR and reduced P-PTEN and caspase-3. The present study suggests that the improvement of cognitive and sensorimotor deficits by PNS-Rb1 is made, at least partially, by the modulation of the Akt/mTOR/PTEN signalling pathway.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  2 / 13239 MEDLINE  
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[PMID]: 29474858
[Au] Autor:Cheong DHJ; Arfuso F; Sethi G; Wang L; Hui KM; Kumar AP; Tran T
[Ad] Address:Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 117593, Singapore.
[Ti] Title:Molecular targets and anti-cancer potential of escin.
[So] Source:Cancer Lett;422:1-8, 2018 Feb 21.
[Is] ISSN:1872-7980
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:Escin is a mixture of triterpenoid saponins extracted from the horse chestnut tree, Aesculus hippocastanum. Its potent anti-inflammatory and anti-odematous properties makes it a choice of therapy against chronic venous insufficiency and odema. More recently, escin is being actively investigated for its potential activity against diverse cancers. It exhibits anti-cancer effects in many cancer cell models including lung adenocarcinoma, hepatocellular carcinoma and leukemia. Escin also attenuates tumor growth and metastases in various invivo models. Importantly, escin augments the effects of existing chemotherapeutic drugs, thereby supporting the role of escin as an adjunct or alternative anti-cancer therapy. The beneficial effects of escin can be attributed to its inhibition of proliferation and induction of cell cycle arrest. By regulating transcription factors/growth factors mediated oncogenic pathways, escin also potentially mitigates chronic inflammatory processes that are linked to cancer survival and resistance. This review provides a comprehensive overview of the current knowledge of escin and its potential as an anti-cancer therapy through its anti-proliferative, pro-apoptotic, and anti-inflammatory effects.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  3 / 13239 MEDLINE  
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[PMID]: 29454914
[Au] Autor:Wang YH; Shi M; Niu HM; Yang J; Xia MY; Luo JF; Chen YJ; Zhou YP; Li H
[Ad] Address:Key Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China; Southeast Asia Biodiversity Research Institute, Chinese Academy of Sciences, Yezin, Nay Py
[Ti] Title:Substituting one Paris for another? In vitro cytotoxic and in vivo antitumor activities of Paris forrestii, a substitute of Paris polyphylla var. yunnanensis.
[So] Source:J Ethnopharmacol;218:45-50, 2018 Feb 15.
[Is] ISSN:1872-7573
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:ETHNOPHARMACOLOGICAL RELEVANCE: Chong-lou (Paris polyphylla var. yunnanensis or P. polyphylla var. chinensis) is traditionally used as an anticancer medicine in China. It is also the material basis of some Chinese patent anticancer medicines, such as Gan-Fu-Le capsules, Bo-Er-Ning capsules, Lou-Lian capsules, Ruan-Jian oral liquid, and Qi-Zhen capsules. P. forrestii, a substitute for Chong-lou, is planted at a large scale in the Yunnan Province of China. AIM OF THE STUDY: To clarify the active chemical constituents of P. forrestii and evaluate the in vitro and in vivo anticancer activities of the total saponins from P. forrestii. MATERIALS AND METHODS: The total saponins of P. forrestii were extracted and separated to yield pure compounds by chromatographic techniques, and the structures of the isolates were elucidated by spectroscopic methods. The cytotoxicity of the crude extracts, total saponins, and chemical constituents were evaluated using an MTS assay. In vivo antitumor activities of the total saponins from P. forrestii were measured using H22 tumor-bearing mice by intraperitoneal (ip) administration. RESULTS: Eight compounds, including polyphyllin D (1), formosanin C (2), dioscin (3), diosgenin-3-O-α-l-rhamnopyranosyl-(1→2)--d-glucopyranoside (4), paris saponin H (5), pennogenin-3-O-α-l-rhamnopyranosyl-(1→2)-[α-l-rhamnopyranosyl-(1→4)]--d-glucopyranoside (6), pariposide A (7), and crustecdysone (8), were isolated from the total saponins of P. forrestii. The total saponins and compounds 1-6 showed significant inhibitory activity against the growth of the HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines. The total saponins from P. forrestii had a tumor-inhibitory effect in H22 tumor-bearing mice upon ip (2.25 mg/kg dose) administration, with an inhibition rate of 42.6% compared with cisplatin (ip, 2 mg/kg dose, 53.9% inhibition rate). CONCLUSION: The results support that P. forrestii could be a substitute for P. polyphylla var. yunnanensis as an anticancer medicine.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  4 / 13239 MEDLINE  
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[PMID]: 29381775
[Au] Autor:Sundaramoorthy J; Park GT; Mukaiyama K; Tsukamoto C; Chang JH; Lee JD; Kim JH; Seo HS; Song JT
[Ad] Address:School of Applied Biosciences, Kyungpook National University, Daegu, Republic of Korea.
[Ti] Title:Molecular elucidation of a new allelic variation at the Sg-5 gene associated with the absence of group A saponins in wild soybean.
[So] Source:PLoS One;13(1):e0192150, 2018.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:In soybean, triterpenoid saponin is one of the major secondary metabolites and is further classified into group A and DDMP saponins. Although they have known health benefits for humans and animals, acetylation of group A saponins causes bitterness and gives an astringent taste to soy products. Therefore, several studies are being conducted to eliminate acetylated group A saponins. Previous studies have isolated and characterized the Sg-5 (Glyma.15g243300) gene, which encodes the cytochrome P450 72A69 enzyme and is responsible for soyasapogenol A biosynthesis. In this study, we elucidated the molecular identity of a novel mutant of Glycine soja, 'CWS5095'. Phenotypic analysis using TLC and LC-PDA/MS/MS showed that the mutant 'CWS5095' did not produce any group A saponins. Segregation analysis showed that the absence of group A saponins is controlled by a single recessive allele. The locus was mapped on chromosome 15 (4.3 Mb) between Affx-89193969 and Affx-89134397 where the previously identified Glyma.15g243300 gene is positioned. Sequence analysis of the coding region for the Glyma.15g243300 gene revealed the presence of four SNPs in 'CWS5095' compared to the control lines. One of these four SNPs (G1127A) leads to the amino acid change Arg376Lys in the EXXR motif, which is invariably conserved among the CYP450 superfamily proteins. Co-segregation analysis showed that the missense mutation (Arg376Lys) was tightly linked with the absence of group A saponins in 'CWS5095'. Even though Arg and Lys have similar chemical features, the 3D modelled protein structure indicates that the replacement of Arg with Lys may cause a loss-of-function of the Sg-5 protein by inhibiting the stable binding of a heme cofactor to the CYP72A69 apoenzyme.
[Mh] MeSH terms primary: Alleles
Genes, Plant
Saponins/genetics
Soybeans/genetics
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Saponins)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:180131
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0192150

  5 / 13239 MEDLINE  
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[PMID]: 29510543
[Au] Autor:Wang J; Song H; Wu X; Zhang S; Gao X; Li F; Zhu X; Chen Q
[Ad] Address:Department of Pharmacy, School of Pharmaceutical Science, Xiamen University, Xiamen 361102, China. diaoli187@163.com.
[Ti] Title:Steroidal Saponins from Vernonia amygdalina Del. and Their Biological Activity.
[So] Source:Molecules;23(3), 2018 Mar 05.
[Is] ISSN:1420-3049
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:In the present study, four new steroidal saponins, namely vernoniamyoside A-D ( - ), together with the two known steroidal saponins vernoamyoside D ( ) and vernonioside B2 ( ) were isolated from the ethanol extract of leaves of the African medicinal plant Del. (Asteraceae). Their structures were demonstrated by spectral analyses along with 1D and 2D nuclear magnetic resonance (NMR) techniques and mass spectrometry (MS). The cytotoxicity of the compounds was also tested by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method on the cell lines Hela, MCF-7, BT-549 and MDA-MB-231. Vernoniamyoside A, vernoniamyoside B, and vernonioside B2 showed cytotoxicity towards BT-549 cell lines. Vernoniamyoside C, vernoniamyoside D and vernoamyoside D showed different levels of cytotoxic activities.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Process

  6 / 13239 MEDLINE  
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[PMID]: 29509694
[Au] Autor:Liu Y; Wang M; Liu K; Qiu P; Zhang S; Lu Y; Tang N; Tang H
[Ad] Address:Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China. so870823@163.com.
[Ti] Title:New Steroidal Saponins from the Rhizomes of Paris vietnamensis and Their Cytotoxicity.
[So] Source:Molecules;23(3), 2018 Mar 06.
[Is] ISSN:1420-3049
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Four new spirostanol saponins, named pavitnosides A-D ( - ), with six known steroidal saponins - were isolated from the rhizomes of . Their chemical structures were determined based on extensive spectroscopic studies and chemical methods. The aglycones of pavitnoside B and pavitnoside C were not reported in previous work. The cytotoxicity of all saponins was evaluated against human glioblastoma U87MG and U251 cell lines. The new spirostanol saponin displayed weak anti-proliferative activity against U87MG cell line and the known saponins and exhibited significant cytotoxicity against the two tumor cell lines, with IC values of 2.16 to 3.14 M, but did not affect the growth of primary cultures of human astrocytes.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:In-Process

  7 / 13239 MEDLINE  
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[PMID]: 29329092
[Au] Autor:Tian Z; Pang H; Zhang Q; Du S; Lu Y; Zhang L; Bai J; Li P; Li D; Zhao M; Chen X
[Ad] Address:School of Chinese Materia Medica, Beijing University of Chinese Medicine, 6#, WangjingZhonghuanNanlu, Chaoyang District, Beijing 100102, China; School of Pharmaceutical Science, Tsinghua University, Shuangqinglu, Beijing, China.
[Ti] Title:Effect of aspirin on the pharmacokinetics and absorption of panax notoginseng saponins.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1074-1075:25-33, 2018 Feb 01.
[Is] ISSN:1873-376X
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:BACKGROUND: Panax notoginseng saponins, a traditional Chinese medicine extraction, and aspirin are both widely used to treat cerebral infarction in China. Good results in clinical practice have been achieved, when Panax notoginseng saponins was taken together with aspirin. METHODS: To investigate the interaction of the two drugs in vivo, the concentration of notoginsenoside R , ginsenoside Rg , Rb , Re and Rd. in blood were simultaneously measured by UPLC/MS/MS. Sample preparation was carried out by the protein precipitation technique with an internal standard saikosaponin A standard. The separation of six components was achieved by using an ACQUITY UPLC BEH C18 column (1.7m 2.1100mm) by gradient elution using water (containing 0.2% formic acid) and acetonitrile (containing 0.2% formic acid) as the mobile phase at a flow rate of 0.2mL/min. The pharmacokinetic parameters were determined using non-compartmental analysis. The transport of notoginsenoside R , ginsenoside Rg , Rb , Re and Rd. in MDCK -MDR1 cell monolayer was also used to verify the conclusion of pharmacokinetic drug-drug interaction and study the mechanism of drug interaction. RESULTS: The concentrations of the five components increased in a certain extent when the two drugs administered together in rats. The values of apparent permeability coefficients were significantly increased when the two drugs were used together. Aspirin and salicylic acid could destroy the tight junction protein and open the intercellular space to increase the absorption of Panax notoginseng saponins. CONCLUSION: Pharmacokinetic drug-drug interaction in vivo existed between Panax notoginseng saponins and aspirin. The drug-drug interaction mainly occurred in the process of absorption.
[Mh] MeSH terms primary: Aspirin/pharmacokinetics
Drugs, Chinese Herbal/pharmacokinetics
Panax notoginseng/chemistry
Saponins/blood
Saponins/pharmacokinetics
[Mh] MeSH terms secundary: Animals
Aspirin/pharmacology
Cell Membrane/drug effects
Dogs
Drugs, Chinese Herbal/pharmacology
Herb-Drug Interactions
Limit of Detection
Linear Models
Madin Darby Canine Kidney Cells
Rats
Rats, Sprague-Dawley
Reproducibility of Results
Saponins/chemistry
Saponins/pharmacology
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Drugs, Chinese Herbal); 0 (Saponins); R16CO5Y76E (Aspirin)
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:IM
[Da] Date of entry for processing:180113
[St] Status:MEDLINE

  8 / 13239 MEDLINE  
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[PMID]: 29459314
[Au] Autor:Aziz AT; Alshehri MA; Panneerselvam C; Murugan K; Trivedi S; Mahyoub JA; Hassan MM; Maggi F; Sut S; Dall'Acqua S; Canale A; Benelli G
[Ad] Address:Biology Department, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia.
[Ti] Title:The desert wormwood (Artemisia herba-alba) - From Arabian folk medicine to a source of green and effective nanoinsecticides against mosquito vectors.
[So] Source:J Photochem Photobiol B;180:225-234, 2018 Mar.
[Is] ISSN:1873-2682
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:The development of eco-friendly and effective insecticides is crucial for public health worldwide. Herein, we focused on the desert wormwood (Artemisia herba-alba), a plant widely used in Arabian traditional medicine, as a source of green nanoinsecticides against mosquito vectors, as well as growth inhibitors to be employed against microbial pathogens. Ag nanoparticles (AgNPs) fabricated with the A. herba-alba extract were tested on Indian and Saudi Arabian strains of Anopheles, Aedes and Culex mosquitoes. The chemical profile of the A. herba-alba extract was determined by LC-DAD-MS and H NMR studies. Then, AgNPs were studied using UV-vis spectroscopy, XRD, FTIR spectroscopy, TEM, and EDX analyses. Artemisia herba-alba-synthesized AgNPs showed high larvicidal toxicity against mosquitoes from both Indian and Saudi Arabian strains. LC of AgNPs against Indian strains was 9.76 g/ml for An. stephensi, 10.70 g/ml for Ae. aegypti and 11.43 g/ml for Cx. quinquefasciatus, whereas against Saudi Arabian strains it was 33.58 g/ml for Ae. aegypti and 38.06 g/ml for Cx. pipiens. In adulticidal experiments, A. herba-alba extract showed LC ranging from 293.02 to 450 g/ml, while AgNP LC ranged from 8.22 to 27.39 g/ml. Further, low doses of the AgNPs inhibited the growth of selected microbial pathogens. Overall, A. herba-alba can be further considered as a source of phytochemicals, with special reference to saponins, for effective and prompt fabrication of AgNPs with relevant insecticidal and bactericidal activity against species of high public health importance.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:In-Process

  9 / 13239 MEDLINE  
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[PMID]: 29454248
[Au] Autor:Stefaniak M; Lopatkiewicz G; Antkowiak M; Mlynarski J
[Ad] Address:Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland.
[Ti] Title:Stereocontrolled synthesis of oleanolic saponin ladyginoside A isolated from Ladyginia bucharica.
[So] Source:Carbohydr Res;458-459:35-43, 2018 Mar 22.
[Is] ISSN:1873-426X
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Efficient stereocontrolled synthesis of ladyginoside A isolated from Ladyginia bucharica is described. The presented methodology bases on the -selective glycosylation to construct oleanate-3-O--glycoside from selectively protected d-cellobiose comprising desired -linkage in carbohydrate unit. By using this procedure, dimethyl ester of ladyginoside A (1) (methyl oleanate 3-O-(-d-glucopyranosyl)-(1 → 4)--d-glucuronide methyl ester) was obtained in 16% overall yield. Elaborated synthesis is also demonstrated as useful methodology en route to saponin 2 with additional glucose unit, namely 3-O-[-d-glucopyranosyl-(1 → 4)--d-glucuronide] oleanolic acid 28-O--d-glucopyranosyl ester.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:In-Process

  10 / 13239 MEDLINE  
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[PMID]: 29287793
[Au] Autor:Lu C; Lv J; Dong L; Jiang N; Wang Y; Fan B; Wang F; Liu X
[Ad] Address:Research Center for Pharmacology & Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences(CAAS), Beijing, China.
[Ti] Title:The protective effect of 20(S)-protopanaxadiol (PPD) against chronic sleep deprivation (CSD)-induced memory impairments in mice.
[So] Source:Brain Res Bull;137:249-256, 2018 Mar.
[Is] ISSN:1873-2747
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Sleep deprivation (SD) is associated with oxidative stress that causes learning and memory impairment. 20(S)-Protopanaxadiol (PPD), one of the protopanaxadiol-type saponins, has antioxidant and neuroprotective effect. This study was designed to research the protective effect of PPD against cognitive deficits induced by chronic sleep deprivation (CSD) in mice. The CSD model was induced by subjecting the mice to our self-made Sleep Interruption Apparatus (SIA) continuously for 14 days. The memory enhancing effects of PPD were evaluated by behavioral tests and the related mechanism was further explored by observing the oxidative stress changes in the cortex and hippocampus of mice. The results revealed that PPD (20 and 40 mol/kg, i.p.) administration significantly improved the cognitive performance of CSD model mice in object location recognition experiment, novel object recognition task and Morris water maze test. Furthermore, PPD effectively restored the levels/activities of antioxidant defense biomarkers in the cortex and hippocampus, including the superoxide dismutase (SOD) enzyme activity, catalase (CAT) enzyme activity, glutathione (GSH), and lipid peroxidation (LPO). In conclusion, PPD could attenuate cognitive deficits induced by CSD, and the neuroprotective effect of PPD might be mediated by alleviation of oxidative stress. It was assumed that PPD has the potential to be a neuroprotective substance for cognition dysfunction.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180304
[Lr] Last revision date:180304
[St] Status:In-Data-Review


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