Database : MEDLINE
Search on : Schistosomiasis and japonica [Words]
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[PMID]: 29355611
[Au] Autor:Wu S; Tseng Y; Xu N; Yin X; Xie X; Zhang L; Wu W; Zhu W; Wu W; Yao J; Wu Y
[Ad] Address:Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Shanghai Institute of Liver Diseases, Shanghai 200032, China.
[Ti] Title:Evaluation of transient elastography in assessing liver fibrosis in patients with advanced schistosomiasis japonica.
[So] Source:Parasitol Int;67(3):302-308, 2018 Jan 31.
[Is] ISSN:1873-0329
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Schistosomiasis remains an important public health issue. The presence and extent of liver fibrosis are associated with disease progression and prognosis. The study is aimed at exploring the value of liver stiffness measurement (LSM) by transient elastography in assessing liver fibrosis in patients with advanced schistosomiasis japonica. Seventy-three patients were consecutively recruited for the purpose of this study. The correlation between noninvasive parameters and histological fibrosis stages was analyzed and an area under receiver operating characteristic curve (AUROC) was used to assess diagnostic efficacy. Our results demonstrated that there are significant differences between LSM values of patients with different stages of fibrosis (F1 vs. F2, F2 vs. F3 and F3 vs. F4, P<0.01). The AUROC values of LSM in detecting significant fibrosis (F≥2), advanced fibrosis (F≥3) and cirrhosis (F=4) were 0.96, 0.90, and 0.92 respectively. The optimal cut-off LSM values were 8.0kPa, 9.5kPa, and 18.0kPa for significant fibrosis, advanced fibrosis and cirrhosis. Based on differences between AUROC values, LSM was proven to be superior to several serum models in detecting advanced fibrosis and cirrhosis. In conclusion, our study demonstrates that LSM is a reliable parameter for assessing risk of liver fibrosis in patients with advanced schistosomiasis japonica.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180223
[Lr] Last revision date:180223
[St] Status:Publisher

  2 / 2206 MEDLINE  
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[PMID]: 29469508
[Au] Autor:Yi-An W; Wei W; You-Sheng L
[Ad] Address:Jiangsu Institute of Parasitic Diseases, Key Laboratory of National Health and Family Planning Commission on Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasites and Vector Control Technology, Wuxi 214064, China.
[Ti] Title:[Role of goat in transmission of schistosomiasis japonica IV Goat breeding in endemic regions and role of goat in schistosomiasis transmission].
[So] Source:Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi;28(6):606-608, 2016 Oct 17.
[Is] ISSN:1005-6661
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:This review describes the major species, number, breeding pattern, ratio of fenced to freely grazed goat, susceptibility to , pattern of infection, infection rate, intensity of infection, fecal contamination of goat that were bred in 5 marshland and lake provinces of Hunan, Hubei, Jiangxi, Anhui and Jiangsu, and two mountainous provinces of Yunnan and Sichuan, and demonstrates the associations of infected goat distribution with the distribution of infected snails and humans. Considering the huge number of goat which were predominantly grazed freely in marshland and lake endemic regions of China, the high infection rate, numerous environmental pollution by goat feces, as well as the close correlation between the infected goat distribution and infected snail distribution, goat is considered as a major infectious source for schistosomiasis japonica in China, and to play a critical role in the transmission of the disease. Since the control of schistosomiasis in animals is critical to schistosomiasis interruption and elimination, it is suggested that the integrated management of goat schistosomiasis should be included in the national schistosomiasis control program of China.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[St] Status:In-Process
[do] DOI:10.16250/j.32.1374.2016184

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[PMID]: 29469480
[Au] Autor:Xue-Hui S; Jian-Rong D; Le-Ping S; Zhong-Yu F; Ye-Fang L; Guo-Li Q; Wei W; Yun-Tian X; Yi-An W; You-Sheng L
[Ad] Address:Dantu District Center for Disease Control and Prevention, Zhenjiang City, Jiangsu Province, Zhenjiang 212004, China.
[Ti] Title:[Role of goat in transmission of schistosomiasis japonica â…£ Schistosome development in goat and egg count and distribution in goat feces].
[So] Source:Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi;28(6):502-506, 2016 Oct 18.
[Is] ISSN:1005-6661
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To describe the growth and development of in goat and the intensity and temporal distribution of eggs excreted by goat feces, so as to provide baseline data for the control and elimination of the role of goat in the transmission of schistosomiasis. METHODS: The goat animal models of schistosomiasis were established, and stool samples were collected for parasitological examinations. The number of adult worms recovered, variation of schistosomes in goat at different time points post-infection, number of eggs in schistosomes, variation in number and temporal profiles of eggs excreted from goat feces were observed. RESULTS: Of the 6 schistosome-infected goat, 415 adult worms were recovered, with a mean adult worm recovery of 34.58% (range, 23.00% to 45.50%). Among the 5 goat infected with 200 cercariae each, 47, 93, 77, 74 and 73 adult worms were recovered 2, 5, 8, 11 and 14 months post-infection, respectively. There were (200.00±42.33), (226.20±45.88), (168.20±25.85), (183.80±55.13) and (190.80±53.53) eggs detected in female schistosomes. The mean prepatent period of eggs excreted by 10 infected goat was (37.7±3.02) d. From 2 to 14 months post-infection, 7 batches of goat feces were hatched, and there were 30, 23, 14, 1 and 2 times for miracidium intensity of "++++", "+++", "++", "+" and "-", respectively, with 42.86%, 32.86%, 20.00%, 1.43% and 2.86% constituent ratios of miracidium intensity. CONCLUSIONS: Approximately 1/3 cercariae may develop to adults in goats post-infection, and the prepatent period of eggs is (37.7±3.02) d. There is no remarkable decrease seen in the number of adult worms, eggs in female schistosomes and eggs in goat feces within 14 months post-infection. Our findings suggest a long duration for infected goat in the transmission of schistosomiasis, and there is no evidence to prove the "self-cure" phenomenon in goat, indicating that goat is an important source of infection for schistosomiasis japonica.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[St] Status:In-Process
[do] DOI:10.16250/j.32.1374.2016170

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[PMID]: 29469479
[Au] Autor:You-Sheng L; Yi-An W; Xue-Hui S; Wei W; Guo-Li Q; Yun-Tian X; Jian-Rong D
[Ad] Address:Jiangsu Institute of Parasitic Diseases, Key Laboratory of National Health and Family Planning Commission on Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasites and Vector Control Technology, Wuxi 214064, China.
[Ti] Title:[Role of goat in transmission of schistosomiasis japonica III Environmental contamination by goat feces and prediction of environments at high risk of infection].
[So] Source:Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi;28(6):497-501, 2016 Oct 18.
[Is] ISSN:1005-6661
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To quantitatively estimate the range and area of environmental contamination by the feces of -infected that were freely grazed, so as to provide the theoretical evidence for the scientific assessment of the role of the freely grazed goat in the transmission of schistosomiasis japonica and development of control strategy. METHODS: All the fecal samples excreted by the infected goat at daytime (12 h) were collected by using a self-made goat fecal collector, weighed and counted. The quantity and dispersal of the feces excreted by the freely grazed goat at daytime under a natural condition were investigated, and the walking route and speed of the freely grazed goat at daytime were recorded with a multifunction GPS data logger. The maximum range and area of the environment contaminated by the feces of the freely grazed goat at daytime were estimated, and the maximum range and area of the snails that may be infected by the schistosome miracidium released from the eggs in the fecal samples of the freely graze goat at daytime were calculated. RESULTS: During the walking along the marshland at daytime (12 h), the quantity of the feces execrated by the freely grazed infected goat was (232.8 ± 39.8) g per goat, and the fecal samples were composed of (819.2 ± 152.1) pellets. The goat had a mean walking speed of (0.522 7 ± 0.099 7) km/h, and the longest distance, largest radius and largest range of walking activity were (6.272 4 ± 1.195 8) km, 3.136 2 km and (3 191.113 0 ± 1 189.709 4) hm at daytime, respectively. The area of the snails that may be infected by the miracidium released from the eggs in the fecal samples of the freely graze goat (range of key regions for infected snails detection and control) at daytime was estimated to be (3 210.717 5 ± 1 190.907 3) hm . CONCLUSIONS: The intensity of environmental contamination by the eggs in the fecal samples of the freely grazed goat is linked to the number of infected goat. The contamination range caused by the feces of the freely grazed goat with fixed fences is relatively stably kept within the walking range at day-time, and the range and area of goat fecal contamination is associated with the number of households that breed goat and the distribution of goat fence. The area of the snails that may be infected by the miracidium released from the eggs in the fecal samples of the freely graze goat is larger than the area of setting contaminated by the eggs in the goat feces, indicating that the range of infected snail examination and control is larger than the range of goat feces detected.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[St] Status:In-Process
[do] DOI:10.16250/j.32.1374.2016165

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[PMID]: 29469478
[Au] Autor:Guo-Li Q; Jian-Rong D; Yi-An W; Yun-Tian X; Xue-Hui S; Wei W; You-Sheng L
[Ad] Address:Jiangsu Institute of Parasitic Diseases, Key Laboratory of National Health and Family Planning Commission on Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasites and Vector Control Technology, Wuxi 214064, China.
[Ti] Title:[Role of goat in transmission of schistosomiasis japonica III Effect of temperature and humidity on survival of eggs in goat feces and egg survival in natural environments].
[So] Source:Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi;28(6):490-496, 2016 Oct 20.
[Is] ISSN:1005-6661
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To investigate the survival of Schistosoma japonicum eggs in goat feces in natural marshlands and the factors affecting its survival, so as to provide evidences for understanding of the role of eggs in goat feces in the transmission of schistosomiasis and the development of the interventions pertaining to disease control and elimination. METHODS: The goat animals of schistosomiasis japonica were modeled in laboratory, and the feces of infected goat were collected. In laboratory, the effects of environmental temperature and water content in goat feces on egg hatching were evaluated, and in the field, the effect of duration of goat feces on marshland on egg hatching and the effect of direct sunshine on egg survival were evaluated. RESULTS: At 25°C in laboratory, the hatching rate of eggs in goat feces washigh-positively correlated with the water content in goat feces ( = 0.87). If the water content reduced to 7.6% in goat feces, the eggs in goat feces lost the ability to hatch. Under the same water content in goat feces, the hatching rate of eggs gradually decreased with the extension of the duration of exposure of goat feces to -5 °C, which reduced to 0 following 5 h exposure. At 5, 15 and 25 °C, the hatching rates of eggs gradually decreased with the extension of the duration of exposure of goat feces, and themiracidium hatching ratesof eggs were 2.3%, 5% and 0.9% respectively following the exposure for 52 d. At 35°C, the hatching rate of eggs gradually decreased with the extension of the duration of exposure, which reduced to 0 following 13 d exposure. In winter (-2-10 °C), the hatching rate of eggs gradually decreased with the extension of the duration of exposure of goat feces on marshlands, which reduced to 0 after 21 d of exposure, and in spring (16-19 °C), the hatching rate of eggs gradually decreased with the extension of the duration of exposure of goat feces on marshlands, which reduced to 0.9% after 5 d of exposure. At the same time point on the same marshland, the hatching rate of eggs in goat feces exposed to marshlands with direct sunshine was lower than that without direct sunshine. CONCLUSIONS: The survival of eggs in goat feces is associated with environmental temperature and water content (humidity) in goat feces, and the temperature and humidity are major natural factors affecting egg hatching.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[St] Status:In-Process
[do] DOI:10.16250/j.32.1374.2016169

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[PMID]: 29469477
[Au] Autor:Jian-Rong D; Xue-Hui S; Guo-Li Q; Yi-An W; Yun-Tian X; Wei W; You-Sheng L
[Ad] Address:Jiangsu Institute of Parasitic Diseases, Key Laboratory of National Health and Family Planning Commission on Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasites and Vector Control Technology, Wuxi 214064, China.
[Ti] Title:[Role of goat in transmission of schistosomiasis japonica III Development of goat feces collector and optimization of fecal hatching technique].
[So] Source:Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi;28(6):485-489, 2016 Oct 20.
[Is] ISSN:1005-6661
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To develop a simple, feasible goat feces collector to improve the collection accuracy and integrity of goat fecal samples without pollution, and to modify the miracidium hatching test with a plastic tube to achieve simple, standard and comparative procedures, so as to provide technical support for pathogenic diagnosis and scientific research of goat schistosomiasis japonica. METHODS: According to the body features of goat in marshland regions, a goat fecal collector, which was made of coarse fabric cottons, was devised, which was able to be fixed onto the goat buttocks and avoid urine pollution. Prior to miracidium hatching test, the goat fecal samples were pieced by using a mechanical method instead of the conventional artificial piecing method, and the effect of mechanical piecing treatment on miracidium hatching was evaluated. A filter membrane was added between the tube and rubbery ring to block the floater in fecal residues into the tube. The effects on miracidium hatching by using thin fat-free cotton, thick fat-free cotton, nylon gauze at 100 pores/25.4 mm and 150 pores/25.4 mm were compared. RESULTS: The goat feces collector was composed of foreleg fixing garment, hindleg fixing garment and stool bag. The functions of the fixing garment were as a fixed collector to allow non-shift and tolerance of weight during goat activity, while the major function of stool bag was in storage of stool. The goat activity did not affect by the use of collector, and all fecal samples were excreted to the bag. This collector was easy to perform and could avoid urine pollution, which was reusable after cleaning. Prior to miracidium hatching, the goat fecal samples, together with water, were pieced at 18000 to 23000 r/min for successive three times in a cooking machine, of 10 s each time at an interval of 5 s. Mechanical piecing had no clear-cut effect on miracidium hatching of eggs in fecal samples. A total of 541, 620, 344 and 211 miracidia were detected by using the miracidium hatching test with nylon gauze at 100 pores/25.4 mm and 150 pores/25.4 mm , thin fat-free cotton and thick fat-free cotton respectively, indicating a better detection efficacy by using nylon gauze at 100 pores/25.4 mm and 150 pores/25.4 mm . CONCLUSIONS: The goat fecal collector is a easy-to-perform, accurate, unpolluted and reusable device to collect goat feces, which is suitable for pathogenic diagnosis of goat schistosomiasis. Mechanical piecing and use of nylon gauze at 150 pores/25.4 mm allow a simple, accurate and stable technique for parasitological diagnosis of schistosomiasis japonica, which provides a reliable tool for schistosomiasis control and research.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[St] Status:In-Process
[do] DOI:10.16250/j.32.1374.2016174

  7 / 2206 MEDLINE  
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[PMID]: 29469476
[Au] Autor:Jiao-Jiao L
[Ad] Address:Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences; Key Laboratory of Animal Parasitology, Ministry of Agriculture, Shanghai 200241, China.
[Ti] Title:[Strengthening the control of goat schistosomiasis to facilitate the progress towards elimination of schistosomiasis in China].
[So] Source:Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi;28(6):481-484, 2016 Oct 20.
[Is] ISSN:1005-6661
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:Although great success has been achieved in schistosomiasis control, schistosomiasis japonica remains a publichealth concern in China. is found to naturally infect over 40 mammalian animals. The implementation of the integrated schistosomiasis control strategy emphasizing infectious source control since 2004, which integrates replacement of bovines with machines, breeding domestic animals in fences, building safe pastures and chemotherapy of infected bovines, results in a clear-cut reduction in the prevalence of infection in both humans and bovines, as well as the areas of infected snail habitats, and the national schistosomiasis control program is moving from transmission control towards transmission interruption and elimination. It has been found that goat is highly susceptible to infection, and previous epidemiological data have shown a high prevalence of infection in goat. However, the role of goat in the transmission of schistosomiasis japonica has not been paid much attention, and there are few systematic surveys to evaluate the role of goat in schistosomiasis transmission in China to date. Professor Liang Yousheng's group investigated development and reproduction (egglaying) in goat body, environmental contamination by goat feces, and the effect of temperature and humidity on the survival of eggs in goat feces. Their findings further demonstrate the role of goat in the transmission of schistosomiasis japonica. In addition, they proposed, based on their findings and previous reports, that the management of goat should be integrated into the national schistosomiasis control program in China, since goat is virtually one of the major infectious sources of schistosomiasis japonica in China. Moreover, this group improved the fecal hatching test and optimized the parasitological technique for diagnosis of infection in goats. These innovative studies fill in the gaps of goat schitsosomiasis japonica research in China, and the research outcomes will enrich the currently implemented integrated schistosomiasis control strategy emphasizing infectious source control, and are believed to play a critical role in schistosomiasis elimination in China. Since schistosomiasis seriously affects goat husbandry development and local famer income, and goat has become a major infectious source of schistosomiasis japonica in China, the control of goat schistosomiaiss will facilitate the progress towards the elimination of schistosomiasis in China, and the following research priorities are suggested: (1) to emphasize the control of goat schistosomiasis, and to integrate the comprehensive management of goat into the national schistosomiasis control program in China; and (2) to develop new techniques, products and interventions for the control of goat schistosomiasis.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[St] Status:In-Process
[do] DOI:10.16250/j.32.1374.2016213

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[PMID]: 29469454
[Au] Autor:Yun X; Zhi-Hong G; Hui-Qun X
[Ad] Address:Jiangxi Provincial Institute of Parasitic Diseases, Nanchang 330006, China.
[Ti] Title:[Clinical features of 14 cases of cerebral schistosomiasis in Jiangxi Province].
[So] Source:Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi;29(6):740-742, 2017 Oct 25.
[Is] ISSN:1005-6661
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To discuss the clinical features of cerebral schistosomiasis. METHODS: The clinical data of fourteen patients with cerebral schistosomiasis from March 2010 to March 2016 were collected and analyzed retrospectively. RESULTS: The schistosomiasis immunological tests of sera and cerebrospinal fluids from the fourteen patients were all positive. Eosinophils increased in ten cases, and the proportion was 5.1%-60.3%. Schistosoma eggs were found in seven cases by the fecal Kato-Katz method. Fourteen cases were all infected with . Twelve cases were diagnosed as chronic type, and two cases as acute type. Thirteen patients received medical treatment, of which twelve were cured, and one improved. One patient received the surgical resection of the lesion. CONCLUSIONS: The clinical manifestations of cerebral schistosomiasis mainly include seizure, headache, dizziness and fever. In the enhanced head magnetic resonance imaging (MRI), the lesions are clustered and merged into lumps, which is the characteristic image of cerebral schistosomiasis japonica. The praziquantel treatment can achieve a good prognosis.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[St] Status:In-Process
[do] DOI:10.16250/j.32.1374.2017062

  9 / 2206 MEDLINE  
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[PMID]: 29469441
[Au] Autor:Li-Juan Z; Zhi-Min X; Ying-Jun Q; Hui D; Shan L; Jing X; Shi-Zhu L; Xiao-Nong Z
[Ad] Address:National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Center for Tropical Diseases, Key Laboratory of Parasite and Vector Biology, National Health and Family Planning Commission, Shanghai 200025, China.
[Ti] Title:[Endemic status of schistosomiasis in People's Republic of China in 2016].
[So] Source:Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi;29(6):669-677, 2017 Dec 28.
[Is] ISSN:1005-6661
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:This report presents the endemic status of schistosomiasis in the People's Republic of China at national level in 2016, and analyzes the data collected from the national schistosomiasis prevention and control system and 454 national schistosomiasis surveillance sites. Among the 12 provinces (municipality and autonomous region) of endemic of schistosomiasis japonica in P. R. China, 5 provinces (municipality and autonomous region), i.e., Shanghai, Zhejiang, Fujian, Guangdong and Guangxi, had achieved elimination, and 7 provinces of Sichuan, Yunnan, Jiangsu, Hubei, Anhui, Jiangxi and Hunan had achieved transmission control by the end of 2016. There are 451 endemic counties (cities, districts) covering 257 million people, specifically including 29 692 endemic villages of 69.39 million people at risk. Among the 451 endemic counties (cities, districts), 35.25 % (159/451), 42.35% (191/451) and 22.39% (101/451) reached the criteria of elimination, transmission interruption and transmission control, respectively in 2016. By the end of 2016, it was estimated of 54 454 infections of schistosome, decreased by 29.46% compared with 77 194 in 2015. No acute schistosomiasis case was reported in 2016. There were 30 573 advanced schistosomiasis cases documented in 2016. A total of 8 500 710 individuals received schistosomiasis examinations and 600 individuals were parasitologically diagnosed, decreased by 83.36% compared with 3 606 in 2015. The snail survey was performed in 22 140 endemic villages and snails were found in 7 106 villages, accounting for 32.109% of the total villages, with 20 newly detected villages with snails. The snail survey covered area of 813 963.91 hm and snails were found in an area of 235 096.04 hm , including a newly detected area of 1 346.48 hm . No schistosome-infected snails were found in 2016. A total of 881 050 bovines were raised in the schistosomiasis endemic area. Of them, 510 468 bovines received examinations, resulting in 8 schistosome-infected bovines. There were 147 642 schistosomiasis cases receiving drug treatment in 2016, with 2 303 555 individuals undergoing expanded chemotherapy; there were 9 bovines with schistosomiasis receiving drug treatment, with 439 857 bovines undergoing expanded chemotherapy; a total of 139 483.84 hm area with snail control by using molluscicides, with actual molluscicide-treated area of 73 941.75 hm ; and 3 101.52 hm snail habitants were treated by environmental modification. Based on the data from the 454 national schistosomiasis surveillance sites, the mean infection rate was 0.02% and 0.0078% in humans and bovines, respectively. No schistosome-infected snails were found in all the surveillance sites. The results demonstrate a decline in the endemicity of schistosomiasis in P. R. China compared with the level of 2015. However, the distribution area of snails in China is still large and the infection source of schistosomiasis still exists to some extent in some endemic areas; in some regions, the task to reach the standard of transmission interruption is still arduous. There are still objective factors of epidemic and transmission and risk factors of endemic reversal and rebound for schistosomiasis. So, further control and effective surveillance as well as accurate prevention and control should be implemented to promote the elimination process on schistosomiasis in P. R. China.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[St] Status:In-Process
[do] DOI:10.16250/j.32.1374.2017204

  10 / 2206 MEDLINE  
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[PMID]: 29469347
[Au] Autor:Yu-Xi G; Lian-He Z; Gen Y; Jian-Feng Z; Yong-Ming P; Ying-Hua X
[Ad] Address:Affiliated Hospital of Jiangnan University, Wuxi 214000, China.
[Ti] Title:[MRI findings of cerebral schistosomiasis in acute stage:establishment of experimental model of acute cerebral schistosomiasis with rabbits].
[So] Source:Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi;29(5):554-558, 2017 Jun 26.
[Is] ISSN:1005-6661
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To establish an experimental model of acute cerebral schistosomiasis japonica and explore the MRI manifestations of acute cerebral schistosomiasis. METHODS: Rabbits were divided into 3 groups with 10 rabbits in each group. The rabbits in the experimental group were directly injected with suspension fluid of eggs (0.9 mg, 1 ml) by the cranial drilling method, those in the negative control group were given saline (1 ml) by the same method above-mentioned, and those in the blank control group were not given any treatment. Antibiotic was given to the first two groups after the operation. The clinical manifestations of the 3 groups were observed, and the magnetic resonance imaging (MRI) was performed in 30 days post-operation, and then the brain tissues were taken for pathological examinations. RESULTS: All the rabbits in the experimental group exhibited inappetence, various neurological symptoms including hemiplegia, and weight loss after the operation; while those in the negative control group showed inappetence in 3 days after the operation, and 1 week later, the symptom disappeared; there were no adverse reactions in the blank control group. MRI of the experimental group showed nodular or patchy enhancement on T1WI enhancement, brain edema, abnormal ventricular dilatation, and needle augmentation. SWI displayed hypointense in the abnormal enhanced nodules and flaky hypointense on the operation brain. In the negative control group, 2 rabbits showed abnormal enhancement of the needle canal, and 1 showed mild dilatation of the ventricle. The blank control group showed normal manifestations. The pathological examinations showed abnormal appearances in 10 rabbits of the experimental group, including 6 with egg granuloma nodules, nonspecific granuloma nodules coexisted with perivascular inflammation; no granuloma nodules were found in the negative control group, but 2 rabbits showed vascular inflammation; the blank control group showed the normal brain tissue. CONCLUSIONS: An experimental model of acute cerebral schistosomiasis is successfully established in rabbits by intracranial injection of schistosome eggs. The MRI examination combined with the clinical manifestations can improve the accuracy of early diagnosis of cerebral schistosomiasis.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[St] Status:In-Process
[do] DOI:10.16250/j.32.1374.2017043


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