Database : MEDLINE
Search on : Scleral and Diseases [Words]
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[PMID]: 29523299
[Au] Autor:Venkatesh P; Takkar B; Temkar S
[Ad] Address:Retina and Uvea Services, Dr. R P Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India. Electronic address: venkyprao@yahoo.com.
[Ti] Title:Clinical manifestations of pachychoroid may be secondary to pachysclera and increased scleral rigidity.
[So] Source:Med Hypotheses;113:72-73, 2018 Apr.
[Is] ISSN:1532-2777
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Current imaging advancements have led to emergence of pachychoroid as an association of important vision threatening diseases like chronic serous chorioretinopathy and polypoidal choroidal vasculopathy. While the precise relation between thick choroid and such disorder is being investigated, the etiology behind pachychoroid remains elusive. We hypothesize pachychoroid to be a resultant of impeded vascular outflow due to thick sclera and increased scleral rigidity. We discuss our hypothesis in the perspective of other choroidal manifestations of anomalously thick scleral structure.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:In-Process

  2 / 2518 MEDLINE  
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[PMID]: 29486755
[Au] Autor:Costa EF; Pinto LM; Campos MAG; Gomes TM; Silva GEB
[Ad] Address:Departamento de Medicina I, Universidade Federal do Maranhão, Praça Gonçalves Dias, 21 - Centro, São Luis,, MA, 65020-240, Brazil. elaine.pfc68@gmail.com.
[Ti] Title:Partial regression of large anterior scleral staphyloma secondary to rhinosporidiosis after corneoscleral graft - a case report.
[So] Source:BMC Ophthalmol;18(1):61, 2018 Feb 27.
[Is] ISSN:1471-2415
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Rhinosporidiosis is a rare chronic infection of the mucous membranes caused by the Rhinosporidium seeberi. Approximately 15% of cases of rhinosporidiosis are ocular, occurring mainly in the tarsal conjunctiva. There are only 11 cases of scleral melt with staphyloma formation associated with bulbar conjuctival oculosporidiosis and none of them was associated with partial regression of the scleral ectasia after a corneoscleral tectonic graft. CASE PRESENTATION: a 13-year-old girl with a progressively increasing black mass in the upper nasal part above the cornea of the left eye. The biomicroscopy revealed an oval, bluish mass measuring 10x10x5 mm with congestion of the overlying conjunctiva. Conjunctival biopsy showed sporoblasts of Rinosporidium seeberi. Treatment was conducted by conjunctival resection and tectonic corneoscleral graft (13x13mm) over the staphyloma. Within 1 year of follow-up the patient presented a partial staphyloma reduction, 9x9x2.5 mm, and the patch detached from the lesion. A novel surgical approach was done reducing the corneal patch and no recurrence was seen after 9 months. CONCLUSIONS: This case is one of the largest anterior scleral staphylomas secondary to rhinosporidiosis described in the literature. Scleral anterior staphyloma partial regression is an unusual outcome after a tectonic corneoscleral graft. Infection resolution and graft covering of thinned area contributed to scleral reepithelization.
[Mh] MeSH terms primary: Corneal Transplantation
Rhinosporidiosis/parasitology
Rhinosporidiosis/surgery
Sclera/transplantation
Scleral Diseases/parasitology
Scleral Diseases/surgery
[Mh] MeSH terms secundary: Adolescent
Animals
Conjunctiva/parasitology
Corneal Transplantation/methods
Female
Humans
Recurrence
Rhinosporidium/isolation & purification
Treatment Outcome
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[Js] Journal subset:IM
[Da] Date of entry for processing:180301
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0725-2

  3 / 2518 MEDLINE  
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[PMID]: 29271811
[Au] Autor:Kumar S; Ichhpujani P; Thakur S
[Ad] Address:Department of Ophthalmology, Government Medical College and Hospital, Chandigarh, India.
[Ti] Title:Surgically Induced Scleral Necrosis in a Patient With Rheumatoid Arthritis After AGV Implantation.
[So] Source:J Glaucoma;27(3):e55-e58, 2018 Mar.
[Is] ISSN:1536-481X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Surgically induced scleral necrosis (SINS) is a rare entity that has till date not been reported in a patient of glaucoma undergoing Ahmed glaucoma valve (AGV) implantation. METHODS: We present a case of primary open-angle glaucoma who underwent AGV implantation followed by development of scleral necrosis, involving both the scleral patch graft and host sclera. After failure of surgical and medical management, AGV had to be explanted. The patient was diagnosed with rheumatoid arthritis and had to be treated with steroids and azathioprine for the same. RESULTS: SINS is a potentially disastrous complication of ocular surgery that can occur in patients with systemic diseases like rheumatoid arthritis and requires aggressive management to salvage the eye. CONCLUSION: SINS can occur with AGV implantation. Treatment may require aggressive medical and surgical intervention. It is imperative to evaluate patients for systemic illness before planning an AGV implant.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[St] Status:In-Data-Review
[do] DOI:10.1097/IJG.0000000000000860

  4 / 2518 MEDLINE  
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[PMID]: 29426303
[Au] Autor:Singh S; Shrivastav A; Agarwal M; Gandhi A; Mayor R; Paul L
[Ad] Address:Vitreoretina services, Dr. Shroff's Charity Eye Hospital, 5027, Kedarnath Road, Daryaganj, New Delhi, 110002, India. drshalini15@gmail.com.
[Ti] Title:A rare case of scleral buckle infection with Curvularia species.
[So] Source:BMC Ophthalmol;18(1):35, 2018 Feb 09.
[Is] ISSN:1471-2415
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Scleral buckling is an established modality of treating retinal detachment. Being an external implant the buckle may be prone to infections. We report such a case with a delayed presentation and a rare etiology. CASE PRESENTATION: A 45 year old male presented with redness, foreign body sensation and discharge for one month in his right eye. The patient had undergone a retinal detachment surgery elsewhere 14 years back without any visual gain. Right eye demonstrated no perception of light and the best corrected visual acuity in the left eye was 6/6, N6. On downgaze an exposed and anteriorly displaced scleral buckle was identified with black deposits and mucopurulent material overlying the buckle. Scleral buckle removal was done. On microbiological examination Curvularia species was identified. Successful treatment with antifungals was done. CONCLUSIONS: Scleral buckle infection with dematiaceous fungi is a rare occurrence. To the best of our knowledge this is the first case report describing a buckle infection caused by the curvularia species.
[Mh] MeSH terms primary: Ascomycota/isolation & purification
Eye Infections, Fungal/microbiology
Mycoses/microbiology
Prosthesis-Related Infections/microbiology
Scleral Buckling/adverse effects
[Mh] MeSH terms secundary: Anti-Bacterial Agents/therapeutic use
Antifungal Agents/therapeutic use
Ciprofloxacin/therapeutic use
Drug Therapy, Combination
Eye Infections, Fungal/diagnosis
Eye Infections, Fungal/drug therapy
Fluconazole/therapeutic use
Humans
Male
Middle Aged
Mycoses/diagnosis
Mycoses/drug therapy
Prosthesis-Related Infections/diagnosis
Prosthesis-Related Infections/drug therapy
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 5E8K9I0O4U (Ciprofloxacin); 8VZV102JFY (Fluconazole)
[Em] Entry month:1802
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[Js] Journal subset:IM
[Da] Date of entry for processing:180211
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0695-4

  5 / 2518 MEDLINE  
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[PMID]: 29208836
[Au] Autor:Narang P; Agarwal A
[Ad] Address:Narang Eye Care and Laser Centre, Ahmedabad, India.
[Ti] Title:Clinical outcomes in traumatic pseudophacocele: A rare clinical entity.
[So] Source:Indian J Ophthalmol;65(12):1465-1469, 2017 Dec.
[Is] ISSN:1998-3689
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:PURPOSE: The purpose of this study is to evaluate the clinical outcomes in patients with traumatic pseudophacocele. METHODS: In this retrospective, interventional case series, scleral wound repair with pars plana vitrectomy and glued intrascleral fixation of an intraocular lens (glued IOL) was performed in 5 eyes of 5 patients. Pupilloplasty was performed in 3 cases whereas aniridia glued IOL fixation was done in 1 case that had total avulsion and loss of iris tissue. The main outcome measures were best-corrected visual acuity (BCVA), intraoperative and postoperative complications during the entire follow-up period. RESULTS: The preoperative vision ranged from hand movement to perception of light in all the patients. The mean postoperative BCVA was 0.42 ± 0.21 Snellen's decimal equivalent (SDE) at final follow-up. Postoperatively, all the cases retained good visual acuity with case 1 and case 2 reporting 0.5 SDE, case 3 had 0.33 SDE, case 5 had 0.67 SDE whereas case 4 had a final visual acuity limited to 0.1 SDE due to associated corneal opacity. The mean follow-up period was 20.2 ± 11.7 months (range from 9 months to 36 months). The IOL was well centered, all the wounds were well apposed and the mean postoperative intraocular pressure was 14.6 ± 1.95 mm Hg. No complications were reported in the entire follow-up period. CONCLUSION: The clinical outcomes of management of pseudophacocele were encouraging with retention of reasonably good visual potential in all cases.
[Mh] MeSH terms primary: Eye Injuries/complications
Iris/injuries
Lens Subluxation/etiology
Visual Acuity
Vitreous Hemorrhage/etiology
Wounds, Nonpenetrating/complications
[Mh] MeSH terms secundary: Adult
Eye Injuries/diagnosis
Female
Follow-Up Studies
Humans
Iris/surgery
Lens Implantation, Intraocular/methods
Lens Subluxation/diagnosis
Lens Subluxation/surgery
Male
Middle Aged
Rare Diseases
Reconstructive Surgical Procedures/methods
Retrospective Studies
Tomography, Optical Coherence
Ultrasonography
Vitrectomy/methods
Vitreous Hemorrhage/diagnosis
Vitreous Hemorrhage/surgery
Wounds, Nonpenetrating/diagnosis
Young Adult
[Pt] Publication type:JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Em] Entry month:1712
[Cu] Class update date: 180103
[Lr] Last revision date:180103
[Js] Journal subset:IM
[Da] Date of entry for processing:171207
[St] Status:MEDLINE
[do] DOI:10.4103/ijo.IJO_1068_17

  6 / 2518 MEDLINE  
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[PMID]: 29141386
[Au] Autor:Wu XH; Cao QZ; Hu YX; Lin JN; Lin HT; Chen WR; Liu YZ
[Ad] Address:State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, China.
[Ti] Title:[Clinical characteristics and surgical effect observation of congenital aniridia combined with cataract].
[So] Source:Zhonghua Yan Ke Za Zhi;53(11):821-827, 2017 Nov 11.
[Is] ISSN:0412-4081
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:To analyze the clinical manifestations, surgical approaches and postoperative prognosis for the cases of congenital aniridia combined with cataract. In this retrospective case series, 26 patients diagnosed with congenital aniridia combined with cataract were collected from Zhongshan Ophthalmic Center from February 2002 to August 2016. The Clinical data were collected to analyze the clinical features, surgical approaches and postoperative prognosis. T-test was used for statistical analysis. Twenty-six bilateral congenital aniridia patients were included in the case series, with 50% male cases. The average age for the first visit was (8.72±8.06) years old. Hereditary patients constitutes 30.8% (8/26) of the total number. The proportions for bilateral and unilateral cataracts were 88.5% (23/26) and 11.5% (3/26) respectively, and 49 eyes suffering from both congenital aniridia and cataract were therefore included in the final analysis. The most common morphology cataract subtypes were lamellar cataract (24.5%, 12/49), posterior subcapsular cataract (22.4%, 11/49), and total cataract (18.4%,9/49). The observed ocular comorbidities included nystagmus (36.7%, 18/49), vitreous opacity (28.6%, 14/49), foveal hypoplasia (20.4%, 10/49), ametropia (12.2%, 6/49), exotropia (12.2%, 6/49), congenital glaucoma (12.2%, 6/49), esotropia (4.1%, 2/49), congenital ptosis (4.1%, 2/49), lens ectopia (4.1%, 2/49), scleral staphyloma (2.0%, 1/49) and pigmentary degeneration of retina (2.0%, 1/49). 30.6% (15/49) eyes were performed the cataract extraction surgery. The percentage of postoperative best corrected visual acuity (BCVA) for ≥0.1 and ≥0.3 were 93.3% (14/15) and 20.0% (3/15) respectively. Evaluated ocular pressure (33.3%, 5/15), severe posterior capsular opacification (PCO) (13.3%, 2/15) and choroidal hemorrhage combined with choroidal detachment (6.7%, 1/15) were detected as the postoperative complications. Followed by cataract extraction, 80.0% (12/15) eyes were sequentially performed the intraocular lens implantation, while, 20.0% (3/12) eyes remained aphakia due to ocular comorbidities. Congenital aniridia combined with cataract are rare diseases, calling for the precious retrospective researches. This disorder tended to affect both eyes and occurred hereditary. The clinical courses of the cases presented progressive features. Ocular comorbidities were the crucial factors to influence the surgical approaches and postoperative prognosis. .
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171116
[Lr] Last revision date:171116
[St] Status:In-Data-Review
[do] DOI:10.3760/cma.j.issn.0412-4081.2017.11.005

  7 / 2518 MEDLINE  
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[PMID]: 29119143
[Au] Autor:Skondra D; Westerfeld C; Vavvas DG
[Ad] Address:Retina Service, Department of Ophthalmology, Massachusetts Eye and Infirmary, Harvard Medical School, Boston, MA, USA.
[Ti] Title:Modified Controlled Encircling Scleral Buckle for Retinal Detachment.
[So] Source:J Vitreoretin Dis;1(5):314-316, 2017 Sep-Oct.
[Is] ISSN:2474-1264
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:During encircling scleral buckle placement, the ends of the element are tightened to achieve a shortened radius of the eye. The determining factor of the final buckle height is subjective using usually a combination of the buckle height visualized with the degree of scleral indentation and can be difficult to be taught early on to trainees. Here, we describe a case series in which a modified controlled encircling scleral buckle technique that simplifies and standardizes the achievement of reproducible buckle height of about a 1 mm is objective and easy to be taught. This novel encircling scleral buckling technique successfully achieves a good postoperative scleral buckle height in a reproducible and standardized fashion using objective measurements and it is easier to be taught to trainees.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171114
[Lr] Last revision date:171114
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1177/2474126417725218

  8 / 2518 MEDLINE  
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[PMID]: 29118489
[Au] Autor:Mahajan D; Sharma RL; Chaudhary KP
[Ad] Address:Department of Ophthalmology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.
[Ti] Title:Minimal duration cataract surgery with oblique limbal stab incision technique.
[So] Source:Oman J Ophthalmol;10(3):155-161, 2017 Sep-Dec.
[Is] ISSN:0974-620X
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:PURPOSE: Small incision cataract surgery (SICS) and phacoemulsification with oblique limbal stab incision technique were studied and compared. SETTING: The study was conducted in the Department of Ophthalmology, Indira Gandhi Medical College, Shimla, for 1 year. DESIGN: This was a prospective randomized study. METHODS: One hundred patients undergoing SICS (6-7 mm) were compared with another age- and sex-matched 100 patients undergoing phaco (2.8 mm) surgery with oblique limbal stab incision technique. These two groups were further subdivided into two groups of 50 each. Patients with traumatic cataract, corneal diseases, and preoperative astigmatism >1.5 D were excluded from the study. The patients were subjected to standard preoperative evaluation. Follow-up was done at 1, 2, 4, 6, and 12 weeks. RESULTS: Mean surgically induced astigmatism at 12 weeks was <1 D in both groups (+0.62 D ± 0.34 in Group A and +0.46 D ± 0.39 in Group B) (statistically significant < 0.0010). Mean surgical duration was 690.09 s in SICS and 792.29 s in phacoemulsification (statistically significant, < 0.0010). Visual outcome was between 6/6 and 6/9 in 86% of the patients in Group A and 97% of patients in Group B at 12 weeks. CONCLUSION: SICS and phacoemulsification with this technique yield lesser astigmatism than clear corneal and scleral incisions, with the advantage of extension without suturing in complicated cases of phaco and in patients with rigid intraocular lens phacoemulsification gives better BCVA in a larger proportion of patients at 12 weeks.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171112
[Lr] Last revision date:171112
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.4103/ojo.OJO_76_2015

  9 / 2518 MEDLINE  
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[PMID]: 29111828
[Au] Autor:Zhang J; Sun H; Zhou N; Zhang B; Ma J
[Ad] Address:a Ophthalmology Department , The Third Hospital of Hebei Medical University , Shijiazhuang , China.
[Ti] Title:Preparation and Evaluation of Biodegradable Scleral Plug Containing Curcumin in Rabbit Eye.
[So] Source:Curr Eye Res;:1-7, 2017 Nov 07.
[Is] ISSN:1460-2202
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: To test whether biodegradable curcumin-loaded scleral plug is a promising choice for treating posterior ocular diseases, the study investigated the in vitro release profile of the scleral plug and its safety in vivo. METHODS: Scleral plugs containing 0.5 mg, 1.0 mg and 1.5 mg curcumin were synthesized by a compression-sintering method. These scleral plugs were placed in tubes containing balanced salt solution (BSS) buffer, which was replaced by fresh buffer daily. The curcumin concentration in the removed aliquot was tested daily for 14 days using high-performance liquid chromatography (HPLC). In the study, 44 rabbits were randomly divided into four groups: control, 0.5 mg, 1.0 mg and 1.5 mg curcumin groups. The scleral plug was trans-scleral fixed in the right eye of the rabbits in the three curcumin-treated groups. The control rabbits only received sclerotomy. The treated rabbit eyes were examined by a slit-lamp biomicroscope, an indirect ophthalmoscope and electroretinogram (ERG), and subjected to histological analysis. RESULTS: The concentration of the 1.5 mg curcumin-loaded scleral plug was higher than 15 µg/ml for consecutive 14 days in vitro. The in vivo experiments revealed intraocular pressure, a-wave and b-wave amplitudes of ERG, and conjunctival reaction degree were not significantly different between the four groups. Retinal structure was normal in the curcumin-treated groups. The sclerotomy wound healed after the plug was completely degraded. Anterior chamber reaction or complications were not observed. CONCLUSION: The study suggests that curcumin-loaded scleral plug could sustain high concentration of curcumin in vitro and is safe in vivo. It might be a promising alternative choice for the treatment of posterior ocular diseases.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171107
[Lr] Last revision date:171107
[St] Status:Publisher
[do] DOI:10.1080/02713683.2016.1242753

  10 / 2518 MEDLINE  
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[PMID]: 29111817
[Au] Autor:Puzzolo D; Pisani A; Malta C; Santoro G; Meduri A; Abbate F; Montalbano G; Wylegala E; Rana RA; Bucchieri F; Ieni A; Aragona P; Micali A
[Ad] Address:a Department of Biomedical Sciences , University of Messina , Messina , Italy.
[Ti] Title:Structural, ultrastructural, and morphometric study of the zebrafish ocular surface: a model for human corneal diseases?
[So] Source:Curr Eye Res;:1-11, 2017 Nov 07.
[Is] ISSN:1460-2202
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:PURPOSE: A morphological and morphometric study of the adult zebrafish ocular surface was performed to provide a comprehensive description of its parts and to evaluate its similarity to the human. MATERIALS AND METHODS: The eyes of adult zebrafish were processed for light, transmission and scanning electron microscopy, and for immunohistochemical stain of corneal nerves; a morphometric analysis was also performed on several morphological parameters. RESULTS: The corneal epithelium was formed by five layers of cells. No Bowman's layer could be demonstrated. The stroma consisted of lamellae of different thickness with few keratocytes. The Descemet's membrane was absent as the flat and polygonal endothelial cells directly adhered to the deepest corneal lamella. The immunohistochemical stain of neurofilaments failed to demonstrate corneal nerve fibers. The conjunctival epithelium was stratified, overlying the stroma formed by a subepithelial and a deep layer, this latter connected to the scleral cartilage. In the peripheral cornea and in the conjunctiva, many goblet and rodlet cells were observed. The morphometric analysis showed that the peripheral cornea epithelium was thicker when compared to the other parts of the ocular surface, with smaller superficial cells. Desmosomes and hemidesmosomes in the conjunctiva were significantly fewer in number than the other parts of the ocular surface. The stroma was thinner in the conjunctiva than in the cornea, while corneal lamellae were thicker in the intermediate stroma. CONCLUSIONS: The zebrafish ocular surface showed significant differences compared to the human, such as the absence of Bowman's layer, Descemet's membrane and corneal nerve fibers, the reduced stromal thickness, and the presence of rodlet cells. On the basis of these original findings, it is suggested that the use of the zebrafish as a model for studying normal or pathological human corneas should be undertaken with particular caution.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171107
[Lr] Last revision date:171107
[St] Status:Publisher
[do] DOI:10.1080/02713683.2017.1385087


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