Database : MEDLINE
Search on : Scleredema and Adultorum [Words]
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[PMID]: 29280826
[Au] Autor:Chatterjee S; Hedman BJ; Kirby DF
[Ti] Title:An Unusual Cause of Dysphagia.
[So] Source:J Clin Rheumatol;, 2017 Dec 27.
[Is] ISSN:1536-7355
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Scleredema adultorum of Buschke is a rare scleroderma mimic characterized by woody induration of the skin involving the back of the neck, interscapular region, upper and mid back, and sometimes the face, upper chest, and upper arms. Dysphagia is rare and not well characterized. We describe a case of scleredema that developed significant dysphagia affecting both the oropharyngeal phase and the esophageal phase of deglutition. Diagnostic evaluation revealed mild-moderate oropharyngeal and severe esophageal dysmotility. This is the first reported case of scleredema that exhibited severe dysmotility due to involvement of the smooth muscle of the entire esophagus. This case adds another sclerosing skin disorder to the list of causes of significant symptomatic dysphagia due to pharyngoesophageal dysmotility: systemic sclerosis, scleromyxedema, and chronic graft-versus-host disease. We hypothesize that dysmotility resulted from infiltration of the pharynx and esophagus with acid mucopolysaccharides. However, in the absence of histopathologic evidence, this is purely speculative. To develop an effective therapeutic approach, further studies are needed to understand the underlying pathophysiology of this uncommon but debilitating complication of scleredema.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171227
[Lr] Last revision date:171227
[St] Status:Publisher
[do] DOI:10.1097/RHU.0000000000000666

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[PMID]: 28868289
[Au] Autor:Eckes B; Wang F; Moinzadeh P; Hunzelmann N; Krieg T
[Ad] Address:Department of Dermatology, University of Cologne, Cologne, Germany.
[Ti] Title:Pathophysiological Mechanisms in Sclerosing Skin Diseases.
[So] Source:Front Med (Lausanne);4:120, 2017.
[Is] ISSN:2296-858X
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Sclerosing skin diseases represent a large number of distinct disease entities, which include systemic sclerosis, localized scleroderma, and scleredema adultorum. These pathologies have a common clinical appearance and share histological features. However, the specific interplay between cytokines and growth factors, which activate different mesenchymal cell populations and production of different extracellular matrix components, determines the biomechanical properties of the skin and the clinical features of each disease. A better understanding of the mechanisms underlying these events is prerequisite for developing novel targeted therapeutic approaches.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1709
[Cu] Class update date: 170906
[Lr] Last revision date:170906
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.3389/fmed.2017.00120

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[PMID]: 28738698
[Au] Autor:Mickel M; Jalili A; Gesslbauer C; Crevenna R
[Ad] Address:a Department of Physical Medicine, Rehabilitation and Occupational Medicine , Medical University of Vienna , Vienna , Austria.
[Ti] Title:Implementation and evaluation of a rehabilitation concept in a patient suffering from Scleredema Adultorum Buschke: a case report.
[So] Source:Disabil Rehabil;:1-3, 2017 Jul 24.
[Is] ISSN:1464-5165
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:PURPOSE: Scleredema Adultorum Buschke is a disorder manifesting indurations of the skin mostly followed by musculoskeletal impairment. Data regarding this fact are seldom found and documentation of functional outcome of physical therapies and modalities related to Scleredema Adultorum Buschke is fragmentary. The aim of this case report is to demonstrate and to document an effective concept of rehabilitation in a patient suffering from Scleredema Adultorum Buschke. METHODS: A treatment plan was developed containing therapeutic ultrasound, manual lymphatic drainage, and physiotherapy. Assessments were performed at baseline and after therapy. RESULTS: Treatment by physical therapies of presented patient resulted in an improved functionality. Five out of eight Short Form-36 questionaire sections increased in terms of enhanced general health and level of activity. CONCLUSIONS: Musculoskeletal impairment in a patient suffering from Scleredema Adultorum Buschke can be reduced by a multimodal concept of rehabilitation. Implications for Rehabilitation Rehabilitation professional should suspect scleredema in patients with diffuse skin thickening where hands and feet are spared Essential reactivating physical activity should be supported by skin softening physical modalities irrespective of etiology or primary therapy. There is a need for functional outcome measures and documentation in the rehabilitation of Scleredema Adultorum Buschke.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170725
[Lr] Last revision date:170725
[St] Status:Publisher
[do] DOI:10.1080/09638288.2017.1355939

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[PMID]: 28374407
[Au] Autor:Lima AL; Illing T; Schliemann S; Elsner P
[Ad] Address:Department of Dermatology, University Hospital Jena, Erfurter Straße 35, 07740, Jena, Germany.
[Ti] Title:Cutaneous Manifestations of Diabetes Mellitus: A Review.
[So] Source:Am J Clin Dermatol;18(4):541-553, 2017 Aug.
[Is] ISSN:1179-1888
[Cp] Country of publication:New Zealand
[La] Language:eng
[Ab] Abstract:Diabetes mellitus is a widespread endocrine disease with severe impact on health systems worldwide. Increased serum glucose causes damage to a wide range of cell types, including endothelial cells, neurons, and renal cells, but also keratinocytes and fibroblasts. Skin disorders can be found in about one third of all people with diabetes and frequently occur before the diagnosis, thus playing an important role in the initial recognition of underlying disease. Noninfectious as well as infectious diseases have been described as dermatologic manifestations of diabetes mellitus. Moreover, diabetic neuropathy and angiopathy may also affect the skin. Pruritus, necrobiosis lipoidica, scleredema adultorum of Buschke, and granuloma annulare are examples of frequent noninfectious skin diseases. Bacterial and fungal skin infections are more frequent in people with diabetes. Diabetic neuropathy and angiopathy are responsible for diabetic foot syndrome and diabetic dermopathy. Furthermore, antidiabetic therapies may provoke dermatologic adverse events. Treatment with insulin may evoke local reactions like lipohypertrophy, lipoatrophy and both instant and delayed type allergy. Erythema multiforme, leukocytoclastic vasculitis, drug eruptions, and photosensitivity have been described as adverse reactions to oral antidiabetics. The identification of lesions may be crucial for the first diagnosis and for proper therapy of diabetes.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1704
[Cu] Class update date: 170713
[Lr] Last revision date:170713
[St] Status:In-Process
[do] DOI:10.1007/s40257-017-0275-z

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[PMID]: 28329532
[Au] Autor:Ng E; Rosenstein R; Terushkin V; Meehan S; Pomeranz MK
[Ad] Address:Ronald O. Perelman Department of Dermatology, NYU School of Medicine, NYU Langone Medical Center.
[Ti] Title:Idiopathic scleredema.
[So] Source:Dermatol Online J;22(12), 2016 Dec 15.
[Is] ISSN:1087-2108
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Scleredema, which also is known as scleredemaadultorum of Buschke, is an uncommonsclerodermiform condition that is characterizedby progressive thickening and hardening of theskin due to excessive dermal mucin and collagendeposition. The clinical course is variable, andprogression of disease may lead to functionalimpairment with limitations in mobility. The etiologyand pathogenesis are unknown although severalwell-known associations include streptococcalinfection; diabetes mellitus, particularly withmetabolic syndrome; and monoclonal gammopathy.We present a case of scleredema in a 52-year-oldman with no identifiable associated condition,who experienced improvemement with UVBphototherapy.
[Mh] MeSH terms primary: Scleredema Adultorum/diagnosis
[Mh] MeSH terms secundary: Back
Humans
Male
Middle Aged
Scleredema Adultorum/pathology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171011
[Lr] Last revision date:171011
[Js] Journal subset:IM
[Da] Date of entry for processing:170323
[St] Status:MEDLINE

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[PMID]: 27483076
[Au] Autor:Chatterjee S
[Ad] Address:Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, Ohio.
[Ti] Title:Laboratory Testing in the Setting of Diabetic Scleredema--Reply.
[So] Source:JAMA;316(5):543, 2016 Aug 02.
[Is] ISSN:1538-3598
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Diabetes Mellitus, Type 2/complications
Scleredema Adultorum/diagnosis
Scleredema Adultorum/etiology
[Mh] MeSH terms secundary: Humans
Male
[Pt] Publication type:COMMENT; LETTER
[Em] Entry month:1608
[Cu] Class update date: 161017
[Lr] Last revision date:161017
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:160803
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2016.6647

  7 / 322 MEDLINE  
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[PMID]: 27483073
[Au] Autor:Alter D
[Ad] Address:Spectrum Health Regional Laboratory, Grand Rapids, Michigan.
[Ti] Title:Laboratory Testing in the Setting of Diabetic Scleredema.
[So] Source:JAMA;316(5):542, 2016 Aug 02.
[Is] ISSN:1538-3598
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Diabetes Mellitus, Type 2/complications
Scleredema Adultorum/diagnosis
Scleredema Adultorum/etiology
[Mh] MeSH terms secundary: Humans
Male
[Pt] Publication type:COMMENT; LETTER
[Em] Entry month:1608
[Cu] Class update date: 161017
[Lr] Last revision date:161017
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:160803
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2016.6644

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[PMID]: 27274549
[Au] Autor:Brankov N; Moore B; Messana K; Piliang M
[Ad] Address:Loma Linda University School of Medicine, California, USA.
[Ti] Title:Benign lesion on the posterior aspect of the neck.
[So] Source:Cutis;97(5):348;351;352, 2016 May.
[Is] ISSN:2326-6929
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Collagen/metabolism
Fibroma
Head and Neck Neoplasms
Lipoma/diagnosis
Scleredema Adultorum/diagnosis
Skin
[Mh] MeSH terms secundary: Diagnosis, Differential
Fibroma/diagnosis
Fibroma/metabolism
Fibroma/pathology
Head and Neck Neoplasms/diagnosis
Head and Neck Neoplasms/metabolism
Head and Neck Neoplasms/pathology
Humans
Male
Middle Aged
Skin/metabolism
Skin/pathology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:9007-34-5 (Collagen)
[Em] Entry month:1704
[Cu] Class update date: 170417
[Lr] Last revision date:170417
[Js] Journal subset:IM
[Da] Date of entry for processing:160609
[St] Status:MEDLINE

  9 / 322 MEDLINE  
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[PMID]: 26978211
[Au] Autor:Chatterjee S
[Ad] Address:Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, Ohio.
[Ti] Title:Neck Pain, Stiffness, and Periorbital Edema in a Man With Diabetes.
[So] Source:JAMA;315(11):1159-60, 2016 Mar 15.
[Is] ISSN:1538-3598
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Diabetes Mellitus, Type 2/complications
Scleredema Adultorum/diagnosis
Scleredema Adultorum/etiology
[Mh] MeSH terms secundary: Edema/etiology
Headache/etiology
Humans
Male
Middle Aged
Neck/pathology
Neck Pain/etiology
Scleredema Adultorum/pathology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1603
[Cu] Class update date: 161017
[Lr] Last revision date:161017
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:160316
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2016.1770

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[PMID]: 26536602
[Au] Autor:Mohamed M; Belhadjali H; Béchir AB; Moussa A; Zili J
[Ad] Address:Department of Dermatology, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
[Ti] Title:Scleredema adultorum of Buschke with prominent periorbital edema in a Tunisian patient with diabetes mellitus: a case report.
[So] Source:Int J Dermatol;55(2):e100-2, 2016 Feb.
[Is] ISSN:1365-4632
[Cp] Country of publication:England
[La] Language:eng
[Mh] MeSH terms primary: Diabetes Mellitus/diagnosis
Edema/etiology
Eyelid Diseases/etiology
Scleredema Adultorum/etiology
Scleredema Adultorum/pathology
[Mh] MeSH terms secundary: Adult
Diabetes Complications
Humans
Male
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161230
[Lr] Last revision date:161230
[Js] Journal subset:IM
[Da] Date of entry for processing:151105
[St] Status:MEDLINE
[do] DOI:10.1111/ijd.13128


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