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[PMID]: 25246642
[Au] Autor:Haller S; Barkhof F; Wattjes MP; Lalive PH
[Ad] Address:Department of Imaging and Medical Informatics, University Hospitals of Geneva and Faculty of Medicine of the University of Geneva, Geneva, Switzerland....
[Ti] Title:Transient gadolinium leakage in natalizumab-treated multiple sclerosis.
[So] Source:J Neurol Neurosurg Psychiatry;86(4):475-6, 2015 Apr.
[Is] ISSN:1468-330X
[Cp] Country of publication:England
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1503
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1136/jnnp-2014-309069

  2 / 183045 MEDLINE  
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[PMID]: 24973342
[Au] Autor:Balk LJ; Steenwijk MD; Tewarie P; Daams M; Killestein J; Wattjes MP; Vrenken H; Barkhof F; Polman CH; Uitdehaag BM; Petzold A
[Ad] Address:Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands....
[Ti] Title:Bidirectional trans-synaptic axonal degeneration in the visual pathway in multiple sclerosis.
[So] Source:J Neurol Neurosurg Psychiatry;86(4):419-24, 2015 Apr.
[Is] ISSN:1468-330X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To investigate the coexistence of anterograde and retrograde trans-synaptic axonal degeneration, and to explore the relationship between selective visual pathway damage and global brain involvement in longstanding multiple sclerosis (MS). METHODS: In this single-centre, cross-sectional study, patients with longstanding MS (N=222) and healthy controls (HC, N=62) were included. We analysed thickness of retinal layers (optical coherence tomography), damage within optic radiations (OR) (lesion volume and fractional anisotropy and mean diffusivity by diffusion tensor imaging) and atrophy of the visual cortex and that of grey and white matter of the whole-brain (structural MRI). Linear regression analyses were used to assess associations between the different components and for comparing patients with and without optic neuritis and HC. RESULTS: In patients with MS, an episode of optic neuritis (MSON) was significantly associated with decreased integrity of the ORs and thinning of the peripapillary retinal nerve fibre layer (pRNFL) and macular ganglion cell complex (GCC). Lesion volume in the OR was negatively associated with pRNFL and GCC thickness in patients without optic neuritis (MSNON). The pRNFL and GCC showed associations with integrity of the OR, thickness of the primary visual cortex (only in patients with MSON), and also with global white and grey matter atrophy. In HCs, no such relationships were demonstrated. INTERPRETATION: This study provides evidence for presence of bidirectional (both anterograde and retrograde) trans-synaptic axonal degeneration in the visual pathway of patients with MS. Additionally, thinning of the retinal pRNFL and GCC are related to global white and grey matter atrophy in addition to pathology of the visual pathway.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1136/jnnp-2014-308189

  3 / 183045 MEDLINE  
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[PMID]: 24973341
[Au] Autor:Lukas C; Knol DL; Sombekke MH; Bellenberg B; Hahn HK; Popescu V; Weier K; Radue EW; Gass A; Kappos L; Naegelin Y; Uitdehaag BM; Geurts JJ; Barkhof F; Vrenken H
[Ad] Address:Department of Diagnostic and Interventional Radiology and Nuclear Medicine, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany....
[Ti] Title:Cervical spinal cord volume loss is related to clinical disability progression in multiple sclerosis.
[So] Source:J Neurol Neurosurg Psychiatry;86(4):410-8, 2015 Apr.
[Is] ISSN:1468-330X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To examine the temporal evolution of spinal cord (SC) atrophy in multiple sclerosis (MS), and its association with clinical progression in a large MS cohort. METHODS: A total of 352 patients from two centres with MS (relapsing remitting MS (RRMS): 256, secondary progressive MS (SPMS): 73, primary progressive MS (PPMS): 23) were included. Clinical and MRI parameters were obtained at baseline, after 12 months and 24 months of follow-up. In addition to conventional brain and SC MRI parameters, the annualised percentage brain volume change and the annualised percentage upper cervical cord cross-sectional area change (aUCCA) were quantified. Main outcome measure was disease progression, defined by expanded disability status scale increase after 24 months. RESULTS: UCCA was lower in SPMS and PPMS compared with RRMS for all time points. aUCCA over 24 months was highest in patients with SPMS (-2.2% per year) and was significantly higher in patients with disease progression (-2.3% per year) than in stable patients (-1.2% per year; p=0.003), while annualised percentage brain volume change did not differ between subtypes (RRMS: -0.42% per year; SPMS -0.6% per year; PPMS: -0.46% per year) nor between progressive and stable patients (p=0.055). Baseline UCCA and aUCCA over 24 months were found to be relevant contributors of expanded disability status scale at month-24, while baseline UCCA as well as number of SC segments involved by lesions at baseline but not aUCCA were relevant contributors of disease progression. CONCLUSIONS: SC MRI parameters including baseline UCCA and SC lesions were significant MRI predictors of disease progression. Progressive 24-month upper SC atrophy occurred in all MS subtypes, and was faster in patients exhibiting disease progression at month-24.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1136/jnnp-2014-308021

  4 / 183045 MEDLINE  
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[PMID]: 25632961
[Au] Autor:Mukhopadhyay S; Saqcena M; Chatterjee A; Garcia A; Frias MA; Foster DA
[Ad] Address:From the Department of Biological Sciences, Hunter College of the City University of New York, New York, New York 10065....
[Ti] Title:Reciprocal Regulation of AMP-activated Protein Kinase and Phospholipase D.
[So] Source:J Biol Chem;290(11):6986-93, 2015 Mar 13.
[Is] ISSN:1083-351X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:AMP-activated protein kinase (AMPK), a critical sensor of energy sufficiency, acts as central metabolic switch in cell metabolism. Once activated by low energy status, AMPK phosphorylates key regulatory substrates and turns off anabolic biosynthetic pathways. In contrast, the mammalian/mechanistic target of rapamycin (mTOR) is active when there are sufficient nutrients for anabolic reactions. A critical factor regulating mTOR is phosphatidic acid (PA), a central metabolite of membrane lipid biosynthesis and the product of the phospholipase D (PLD)-catalyzed hydrolysis of phosphatidylcholine. PLD is a downstream target of the GTPase Rheb, which is turned off in response to AMPK via the tuberous sclerosis complex. Although many studies have linked AMPK with mTOR, very little is known about the connection between AMPK and PLD. In this report, we provide evidence for reciprocal regulation of PLD by AMPK and regulation of AMPK by PLD and PA. Suppression of AMPK activity led to an increase in PLD activity, and conversely, activation of AMPK suppressed PLD activity. Suppression of PLD activity resulted in elevated AMPK activity. Exogenously supplied PA abolished the inhibitory effects of elevated AMPK activity on mTOR signaling. In contrast, exogenously supplied PA could not overcome the effect AMPK activation if either mTOR or Raptor was suppressed, indicating that the inhibitory effects of PLD and PA on AMPK activity are mediated by mTOR. These data suggest a reciprocal feedback mechanism involving AMPK and the PLD/mTOR signaling node in cancer cells with therapeutic implications.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1074/jbc.M114.622571

  5 / 183045 MEDLINE  
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[PMID]: 25769372
[Au] Autor:Du X; Usui N; Terada K; Baba K; Matsuda K; Tottori T; Inoue Y
[Ad] Address:National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan; The Third Hospital of ShanXi Medical University, ShanXi, China....
[Ti] Title:Semiological and electroencephalographic features of epilepsy with amygdalar lesion.
[So] Source:Epilepsy Res;111:45-53, 2015 Mar.
[Is] ISSN:1872-6844
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To identify semiological and scalp/sphenoidal electroencephalographic (EEG) features of epilepsy with amygdalar lesion (AL). METHODS: This study included 17 patients with epilepsy and distinct AL on MRI, who underwent resective surgery. There were nine female and eight male patients with ages at surgery ranging from 8 to 48 (mean 26.3) years. Postoperative seizure outcome was Engel class I or seizure-free in 12 patients, class II in four, and class III in one. Pathological examination revealed dysembryoplastic neuroepithelial tumor in eight cases, astrocytoma in two, mixed oligoastrocytoma in three, ganglioglioma in two, localized encephalitis in one, and cortical dysplasia in one. Semiology and scalp/sphenoidal EEG findings of these patients (AL group) were compared with those of 20 mesial temporal lobe epilepsy patients with hippocampal sclerosis (HS) who underwent resective surgery with favorable seizure outcome (Engel class I) (control group). RESULTS: Increased tonic components during seizure were more frequently seen in AL group (58.8%) than in control group (20%). Interictal unitemporal slow waves were more frequently found in AL group (58.8%) than in control group (20%). Ictal EEG revealed generalized (not only bitemporal) onset in six patients in AL group (35.3%), but none in control group. The generalized EEG onset patterns in AL group included spike and wave complexes, rhythmic spikes, and delta waves. CONCLUSION: Patients with AL had increased tonic components during seizure and generalized ictal EEG onset more frequently than patients with HS. These findings suggest widespread epileptic network involving subcortical structures such as the thalamus and the brainstem in patients with AL.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Js] Journal subset:IM
[St] Status:In-Data-Review

  6 / 183045 MEDLINE  
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[PMID]: 25769370
[Au] Autor:Wendling AS; Steinhoff BJ; Bodin F; Staack AM; Zentner J; Scholly J; Valenti MP; Schulze-Bonhage A; Hirsch E
[Ad] Address:Kork Epilepsy Center, Kehl-Kork, Germany; Laboratoire d'Imagerie et Neurosciences Cognitives (CNRS UMR 7237), University of Strasbourg, Strasbourg, France. Electronic address: awendling@epilepsiezentrum.de....
[Ti] Title:Selective amygdalohippocampectomy versus standard temporal lobectomy in patients with mesiotemporal lobe epilepsy and unilateral hippocampal sclerosis: post-operative facial emotion recognition abilities.
[So] Source:Epilepsy Res;111:26-32, 2015 Mar.
[Is] ISSN:1872-6844
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Surgical treatment of mesial temporal lobe epilepsy (mTLE) patients involves the removal either of the left or the right hippocampus. Since the mesial temporal lobe is responsible for emotion recognition abilities, we aimed to assess facial emotion recognition (FER) in two homogeneous patient cohorts that differed only in the administered surgery design since anterior temporal lobectomy (ATL) or selective amygdalohippocampectomy (SAH) were performed independently of the underlying electroclinical conditions. The patient selection for the two respective surgical procedures was carried out retrospectively between 2000 and 2009 by two independent epilepsy centres, the Kork Epilepsy Centre, Germany and the University Hospital of Strasbourg, France. All included patients had presented with unilateral hippocampus sclerosis (HS) without associated dysplasia or white matter blurring and had become seizure-free postoperatively. Psychometric evaluation was carried out with the Ekman 60 Faces Test and screened for depression and psychosomatic symptoms with the SCL-90 R and the BDI. Thirty healthy volunteers participated as control subjects. Sixty patients were included, 27 had undergone SAH and 33 ATL. Patients and controls obtained comparable scores in FER for surprise, happiness, anger and sadness. Concerning fear and disgust the patient group scored significantly worse. Left-sided operations led to the the most pronounced impairment. The ATL group scored significantly worse for recognition of fear compared with SAH patients. Inversely, after SAH scores for disgust were significantly lower than after ATL, independently of the side of resection. Unilateral temporal damage impairs FER. Different neurosurgical procedures may affect FER differently.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Js] Journal subset:IM
[St] Status:In-Data-Review

  7 / 183045 MEDLINE  
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[PMID]: 25769369
[Au] Autor:da Fonseca NC; Joaquim HP; Talib LL; de Vincentiis S; Gattaz WF; Valente KD
[Ad] Address:Laboratory of Clinical Neurophysiology, Institute of Psychiatry, University of So Paulo School of Medicine Hospital das Clnicas, So Paulo, SP, Brazil. Electronic address: nataschafonseca@gmail.com....
[Ti] Title:Hippocampal serotonin depletion is related to the presence of generalized tonic-clonic seizures, but not to psychiatric disorders in patients with temporal lobe epilepsy.
[So] Source:Epilepsy Res;111:18-25, 2015 Mar.
[Is] ISSN:1872-6844
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Previous studies suggest that concentration of serotonin ([5-HT]) plays a pathogenic role in various types of epilepsy inhibiting seizures. However, most have not considered the clinical variables of epilepsy, and all of these studies included small and heterogeneous samples with refractory epilepsy, regardless of etiology. In this work, we measured [5-HT]s in hippocampal tissues from a large series of patients with refractory temporal lobe epilepsy caused by hippocampal sclerosis who underwent epilepsy surgery and evaluated the relationship between [5HT] and epilepsy-related clinical variables and psychiatric disorders. METHODS: We included 44 patients with refractory unilateral TLE-HS who underwent surgical treatment for epilepsy. Hippocampal samples were collected, and serotonin concentrations were measured with high-pressure liquid chromatography (HPLC). RESULTS: Lower [5-HT]s were correlated with a history of GTC seizures (Student's t-test: p 0.041). There were no differences in [5-HT]s according to the other clinical variables and the presence of psychiatric disorders. SIGNIFICANCE: Our findings demonstrated that serotonin depletion in the hippocampus play an important role in some aspects of the severity of epilepsy (i.e., the presence of GTC seizures) in a homogeneous sample of patients with refractory temporal lobe epilepsy determined by hippocampal sclerosis, but not with the presence of psychiatric disorders.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Js] Journal subset:IM
[St] Status:In-Data-Review

  8 / 183045 MEDLINE  
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[PMID]: 25606692
[Au] Autor:Gilbane AJ; Derrett-Smith E; Trinder SL; Good RB; Pearce A; Denton CP; Holmes AM
[Ad] Address:1 Centre for Rheumatology, University College London Division of Medicine, Royal Free Campus, London, United Kingdom; and.
[Ti] Title:Impaired Bone Morphogenetic Protein Receptor II Signaling in a Transforming Growth Factor--Dependent Mouse Model of Pulmonary Hypertension and in Systemic Sclerosis.
[So] Source:Am J Respir Crit Care Med;191(6):665-77, 2015 Mar 15.
[Is] ISSN:1535-4970
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Up to 10% of patients with systemic sclerosis (SSc) develop pulmonary arterial hypertension (PAH). This risk persists throughout the disease and is time dependent, suggesting that SSc is a susceptibility factor. Outcome for SSc-PAH is poor compared with heritable or idiopathic forms, despite clinical and pathological similarities. Although susceptibility in heritable PAH and idiopathic PAH is strongly associated with gene mutations leading to reduced expression of bone morphogenetic protein receptor (BMPR) II, these mutations have not been observed in SSc-PAH. OBJECTIVES: To explore BMPRII expression and function in a mouse model of SSc (TRIIΔk-fib) that is susceptible to developing pulmonary hypertension and in SSc lung. METHODS: BMPRII and downstream signaling pathways were profiled in lung tissue and fibroblasts from the TRIIΔk-fib model, which develops pulmonary vasculopathy with pulmonary hypertension that is exacerbated by SU5416. Complementary studies examined SSc or control lung tissue and fibroblasts. MEASUREMENTS AND MAIN RESULTS: Our study shows reduced BMPRII, impaired signaling, and altered receptor turnover activity in a transforming growth factor (TGF)--dependent mouse model of SSc-PAH. Similarly, a significant reduction in BMPRII expression is observed in SSc lung tissue and fibroblasts. Increased proteasomal degradation of BMPRII appears to underlie this and may result from heightened TGF- activity. CONCLUSIONS: We found reduced BMPRII protein in patients with SSc-PAH and a relevant mouse model associated with increased proteasomal degradation of BMPRII. Collectively, these results suggest that impaired BMP signaling, resulting from TGF--dependent increased receptor degradation, may promote PAH susceptibility in SSc and provide a unifying mechanism across different forms of PAH.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review
[do] DOI:10.1164/rccm.201408-1464OC

  9 / 183045 MEDLINE  
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[PMID]: 24863743
[Au] Autor:Wu L; Walas S; Leung W; Sykes DB; Wu J; Lo EH; Lok J
[Ad] Address:Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
[Ti] Title:Neuregulin1- Decreases IL-1-Induced Neutrophil Adhesion to Human Brain Microvascular Endothelial Cells.
[So] Source:Transl Stroke Res;6(2):116-24, 2015 Apr.
[Is] ISSN:1868-601X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Neuroinflammation contributes to the pathophysiology of diverse diseases including stroke, traumatic brain injury, Alzheimer's disease, Parkinson's disease, and multiple sclerosis, resulting in neurodegeneration and loss of neurological function. The response of the microvascular endothelium often contributes to neuroinflammation. One such response is the upregulation of endothelial adhesion molecules which facilitate neutrophil adhesion to the endothelium and their migration from blood to tissue. Neuregulin-1 (NRG1) is an endogenous growth factor which has been reported to have anti-inflammatory effects in experimental stroke models. We hypothesized that NRG1 would decrease the endothelial response to inflammation and result in a decrease in neutrophil adhesion to endothelial cells. We tested this hypothesis in an in vitro model of cytokine-induced endothelial injury, in which human brain microvascular endothelial cells (BMECs) were treated with IL-1, along with co-incubation with vehicle or NRG1-. Outcome measures included protein levels of endothelial ICAM-1, VCAM-1, and E-selectin, as well as the number of neutrophils that adhere to the endothelial monolayer. Our data show that NRG1- decreased the levels of VCAM-1, E-selectin, and neutrophil adhesion to brain microvascular endothelial cells activated by IL1-. These findings open new possibilities for investigating NRG1 in neuroprotective strategies in brain injury.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Cu] Class update date: 150314
[Lr] Last revision date:150314
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s12975-014-0347-9

  10 / 183045 MEDLINE  
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[PMID]: 25763268
[Au] Autor:Rahmanian M; Kargar M
[Ad] Address:Young Researchers' Club, Department of Microbiology, Jahrom Branch, Islamic Azad University, Jahrom, IR Iran.
[Ti] Title:Tumor necrosis factor-alpha polymorphism and susceptibility to multiple sclerosis in the Iranian population.
[So] Source:Iran Red Crescent Med J;17(1):e18247, 2015 Jan.
[Is] ISSN:2074-1804
[Cp] Country of publication:United Arab Emirates
[La] Language:eng
[Ab] Abstract:BACKGROUND: Multiple sclerosis (MS) is an immune-mediated disease of polygenic etiology. Tumor necrosis factor-α (TNF-α) microsatellite as a proinflammatory cytokine is believed to play an important role in the etiology of this disease. OBJECTIVES: The aim of this study was to investigate the association of TNF-α microsatellite sequence variation in patients with MS and its risk factor in the southern Iranian population. PATIENTS AND METHODS: This polymorphism was investigated in an Iranian population of 163 native southern people [81 patients with MS according to the poser criteria and 82 healthy controls (HC) with the same age, sex, social, ethnical and geographical features (Hormozgan and Fars provinces)]. All the controls were nonimmunological, neurological patients. All the cases and controls were chosen randomly and genotyped for polymorphism of TNF-α microsatellite. RESULTS: The frequencies of TNF-α*11 (0.25, P < 0.005) and TNF-α*10 (P < 0.005) alleles increased in patients with MS compared with controls, showing a significant difference among the studied population. CONCLUSIONS: The current study adds evidence to the association of TNF-α gene polymorphism and MS in this southern south Iranian population which is consistent with the genetic analysis of MS in Europeans (GAMES) project reports and these two alleles reported in this study may be one of the genetic risk factor for MS. Furthermore, this data can be used to build the Iranian gene bank for future studies.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Cu] Class update date: 150314
[Lr] Last revision date:150314
[Da] Date of entry for processing:150312
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.5812/ircmj.18247


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