Database : MEDLINE
Search on : Sebaceous and Gland and Diseases [Words]
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[PMID]: 29451719
[Au] Autor:Schneider MR; Zouboulis CC
[Ad] Address:German Federal Institute for Risk Assessment (BfR), German Centre for the Protection of Laboratory Animals (Bf3R), Berlin, Germany.
[Ti] Title:Primary sebocytes and sebaceous gland cell lines for studying sebaceous lipogenesis and sebaceous gland diseases.
[So] Source:Exp Dermatol;, 2018 Feb 16.
[Is] ISSN:1600-0625
[Cp] Country of publication:Denmark
[La] Language:eng
[Ab] Abstract:Sebocytes, the major cell type in sebaceous glands (SGs), are differentiated epithelial cells that gradually accumulate lipids and eventually disrupt, releasing their content (sebum) in a secretory process known as holocrine secretion. Via the hair canal, sebum reaches the skin surface, where it has several known or postulated functions, including pheromonal, thermoregulatory, antimicrobial and antioxidant activities. Altered sebum secretion and/or structural SG changes have also been involved in the pathogenesis of skin diseases, such as acne vulgaris and some forms of alopecia. Here we assess how recent work employing primary sebocytes and SG cell lines contributed for our understanding of sebaceous lipogenesis and its role in skin health and disease. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1802
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[St] Status:Publisher
[do] DOI:10.1111/exd.13513

  2 / 1176 MEDLINE  
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[PMID]: 28878836
[Au] Autor:Kutlubay Z; Tanakol A; Engýn B; Onel C; Sýmsek E; Serdaroglu S; Tuzun Y; Yilmaz E; Eren B
[Ad] Address:Dermatology Department, Ýstanbul, Cerrahpasa Faculty of Medicine, Ýstanbul University, Istanbul, Turkey.
[Ti] Title:Newborn Skin: Common Skin Problems.
[So] Source:Maedica (Buchar);12(1):42-47, 2017 Jan.
[Is] ISSN:1841-9038
[Cp] Country of publication:Romania
[La] Language:eng
[Ab] Abstract:The newborn skin can be separated from adult's skin in several ways. In dermatologic examination it can be easily observed that it is thinner, less hairy and has less sweat and sebaceous gland secretions. These differentiations present especially in preterm newborns. Their skin is exposed to mechanical trauma, bacteria and weather, heat alterations. At birth, newborn skin is protected by the coverage of vernix caseosa, which has lubricating and antibacterial features and its pH ranges from 6.7 to 7.4. Beneath the vernix caseosa the skin has a pH of 5.5-6.0. In newborn dermatologic examination it is very important to distinguish transient benign dermatoses and severe diseases, make early diagnosis and treat congenital skin disorders. Although the benign cases are common in this life period, clinical presentations can be much more exaggerated, dramatic and cause a great deal of anxiety to parents. Therefore, as a doctor, knowing the dermatological, pathological and non-pathological common skin rashes guides the family in the right direction, offers advice to reduce uncertainty and time for the treatment of severe conditions and builds a confidential doctor-patient relationship. In this review, our aim is to provide a general overview to common skin rashes in newborn period.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170910
[Lr] Last revision date:170910
[St] Status:PubMed-not-MEDLINE

  3 / 1176 MEDLINE  
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[PMID]: 28700664
[Au] Autor:Sundberg JP; Dadras SS; Silva KA; Kennedy VE; Garland G; Murray SA; Sundberg BA; Schofield PN; Pratt CH
[Ad] Address:The Jackson Laboratory, Bar Harbor, Maine, United States of America.
[Ti] Title:Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.
[So] Source:PLoS One;12(7):e0180682, 2017.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The International Knockout Mouse Consortium was formed in 2007 to inactivate ("knockout") all protein-coding genes in the mouse genome in embryonic stem cells. Production and characterization of these mice, now underway, has generated and phenotyped 3,100 strains with knockout alleles. Skin and adnexa diseases are best defined at the gross clinical level and by histopathology. Representative retired breeders had skin collected from the back, abdomen, eyelids, muzzle, ears, tail, and lower limbs including the nails. To date, 169 novel mutant lines were reviewed and of these, only one was found to have a relatively minor sebaceous gland abnormality associated with follicular dystrophy. The B6N(Cg)-Far2tm2b(KOMP)Wtsi/2J strain, had lesions affecting sebaceous glands with what appeared to be a secondary follicular dystrophy. A second line, B6N(Cg)-Ppp1r9btm1.1(KOMP)Vlcg/J, had follicular dystrophy limited to many but not all mystacial vibrissae in heterozygous but not homozygous mutant mice, suggesting that this was a nonspecific background lesion. We discuss potential reasons for the low frequency of skin and adnexal phenotypes in mice from this project in comparison to those seen in human Mendelian diseases, and suggest alternative approaches to identification of human disease-relevant models.
[Mh] MeSH terms primary: Hair/abnormalities
Nails, Malformed/genetics
Skin Abnormalities/genetics
[Mh] MeSH terms secundary: Animals
Mice, Inbred C57BL
Mice, Knockout
Sebaceous Glands/pathology
Skin/pathology
Vibrissae/pathology
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170925
[Lr] Last revision date:170925
[Js] Journal subset:IM
[Da] Date of entry for processing:170713
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180682

  4 / 1176 MEDLINE  
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[PMID]: 28525331
[Au] Autor:Madej JA; Madej JP; Dzimira S; Nowak M
[Ad] Address:.
[Ti] Title:An immunohistochemical analysis of lymphocytic infiltrations in canine skin cancers.
[So] Source:Pol J Vet Sci;20(1):141-147, 2017 Mar 28.
[Is] ISSN:1505-1773
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Lymphocytic infiltrations located in the extracellular matrix often accompany canine skin cancer. They can be characterised as an inflammatory infiltration and/or a second tumour - lymphoma. The aim of this study was an immunohistochemical analysis of a lymphocytic infiltration which accompanies spontaneous skin cancer. Twenty basal cell carcinoma, 20 non-keratinizing squamous cell carcinoma, 20 keratinizing squamous cell carcinoma and 8 sebaceous gland carcinoma samples which were accompanied by a lymphocytic infiltration and/or secondary lymphatic follicles were verified histopathologically. The expression of bcl-2, CD3, CD79α, Ki-67, MCM-3 and MCM-7 in the lymphocytic infiltration was evaluated. Four types of lymphocytic infiltrations were found: I - diffuse bcl-2+, II - diffuse bcl-2-, III - follicular bcl-2+/- where the centre was bcl-2-, and the marginal zone of the follicles and the extrafollicular area were bcl-2+ and IV - aggregated bcl-2+, where the centre and periphery were bcl-2+. The I and IV type corresponds to lymphoma, II type is non-neoplastic immune response and III type suggest reactive follicular hyperplasia. The proliferation of lymphocytes which demonstrated the expression of neoplastic markers (I and IV), suggests preneoplastic phase (pseudolymphoma) or lymphoma - the second independent tumour. A high proliferative index of the follicular blc-2+/- follicular infiltration indicates an increased immunological response of the host against skin cancer.
[Mh] MeSH terms primary: Dog Diseases/pathology
Immunohistochemistry/veterinary
Lymphocytes/physiology
Skin Neoplasms/veterinary
[Mh] MeSH terms secundary: Animals
Dogs
Female
Male
Skin Neoplasms/pathology
Staining and Labeling
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1706
[Cu] Class update date: 170629
[Lr] Last revision date:170629
[Js] Journal subset:IM
[Da] Date of entry for processing:170520
[St] Status:MEDLINE

  5 / 1176 MEDLINE  
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[PMID]: 28358996
[Au] Autor:Munday JS; Marshall S; Thomson NA; Kiupel M; Heathcott RW; French A
[Ad] Address:a Department of Pathobiology, Institute of Veterinary, Animal and Biomedical Sciences , Massey University , Private Bag 11 222, Palmerston North , New Zealand.
[Ti] Title:Multiple viral plaques with sebaceous differentiation associated with an unclassified papillomavirus type in a cat.
[So] Source:N Z Vet J;65(4):219-223, 2017 Jul.
[Is] ISSN:1176-0710
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:CASE HISTORY AND CLINICAL FINDINGS A 15-year-old neutered male domestic short-haired cat was presented due to multiple 0.5-2 cm-diameter crusting plaques in the left preauricular region, over the bridge of nose, and in the right periocular region. The plaques did not appear to cause discomfort. HISTOPATHOLOGICAL FINDINGS Biopsy samples of four plaques were examined histologically. Three plaques consisted of well-demarcated foci of mild epidermal hyperplasia overlying markedly hyperplastic sebaceous glands. Approximately 60% of the hyperplastic cells contained a large cytoplasmic vacuole that ranged from being clear to containing prominent grey-blue fibrillar material. The fourth plaque was composed solely of epidermal hyperplasia, consistent with previous descriptions of feline viral plaques. MOLECULAR BIOLOGY Papillomavirus DNA was amplified from all four plaques using PCR. A single DNA sequence was amplified from the plaques with sebaceous differentiation. This sequence was identical to the FdPV-MY sequence previously suggested to be from a putative unclassified papillomavirus type. Felis catus papillomavirus type 2 sequences were amplified from the plaque typical of feline viral plaques. Immunohistochemistry to detect p16 protein (p16) showed marked immunostaining throughout the hyperplastic epidermis and adnexal structures within the plaques with sebaceous differentiation. DIAGNOSIS Multiple feline viral plaques with variable sebaceous differentiation. CLINICAL RELEVANCE Feline viral plaques with sebaceous differentiation have not been previously reported in cats. The presence of unique cell changes within these lesions, the detection of an unclassified papillomavirus type, and the p16 immunostaining within these plaques suggest that they may have been caused by the papillomavirus that contains the FdPV-MY sequence.
[Mh] MeSH terms primary: Cat Diseases/virology
Papillomavirus Infections/veterinary
[Mh] MeSH terms secundary: Animals
Cat Diseases/diagnosis
Cats
DNA Primers
DNA, Viral/genetics
Face/pathology
Immunohistochemistry
Male
New Zealand
Papillomaviridae
Papillomavirus Infections/diagnosis
Polymerase Chain Reaction/veterinary
Sebaceous Glands/pathology
Sebaceous Glands/virology
Skin
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (DNA Primers); 0 (DNA, Viral)
[Em] Entry month:1709
[Cu] Class update date: 170906
[Lr] Last revision date:170906
[Js] Journal subset:IM
[Da] Date of entry for processing:170331
[St] Status:MEDLINE
[do] DOI:10.1080/00480169.2017.1313146

  6 / 1176 MEDLINE  
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[PMID]: 28330814
[Au] Autor:Tuo J; Wang Q; Zouboulis CC; Liu Y; Ma Y; Ma L; Ying J; Zhang C; Xiang L
[Ad] Address:Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, PR China.
[Ti] Title:ALA-PDT suppressing the cell growth and reducing the lipogenesis in human SZ95 sebocytes by mTOR signaling pathway in vitro.
[So] Source:Photodiagnosis Photodyn Ther;18:295-301, 2017 Jun.
[Is] ISSN:1873-1597
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:BACKGROUND: 5-Aminolevulinic acid mediated -photodynamic therapy (ALA-PDT) is known to be effective in treating acne vulgaris and other sebaceous gland-related diseases. However, the therapeutic mechanisms of ALA-PDT still remain undetermined. In this study, we aimed to investigate the effects and mechanisms of ALA-PDT on the cell growth and lipogenesis of human SZ95 sebocytes. MATERIAL AND METHODS: Human SZ95 sebocytes were treated with different concentration of ALA-PDT.CCK-8 assay was used to detect cell proliferation activity. Fluorescence microscope and flow cytometry were used to observe the secretion of lipids in SZ95 cells after Nile red staining. Western blotting was used to detect and analyze the protein expression level of P-p70 S6K/p70 S6K, P-4E-BP1/4E-BP1, SREBP-1, PPARγ, P-mTOR/mTOR, and P-Raptor/Raptor. Mean while, mTOR pathway activator IGF-1 and mTORC1 inhibitor rapamycin were added to observe the interferences on the ALA-PDT treatment of SZ95 cells. RESULTS: ALA-PDT suppressed the cell growth and reduced the secretion of lipids in a dose-dependent manner in SZ95 cells. ALA-PDT reduced the protein levels of P-p70 S6K (T389), SREBP-1, PPARγ, P-mTOR and P-Raptor. IGF-1 had counter effects on ALA-PDT, and rapamycin enhanced the effects of ALA-PDT in SZ95 cells in suppressing the cell growth and reducing the secretion of lipids. CONCLUSION: ALA-PDT suppressed the cell growth in SZ95 cells by mTOR-p70 S6K(T389) signaling and reduced the lipogenesis in SZ95 cells by mTOR-SREBP-1/PPARγ signaling. Sebaceous glands atrophy and reduction of sebum secretion after ALA-PDT may be caused by the suppression of lipogenesis and cell growth in sebocytes.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1703
[Cu] Class update date: 170616
[Lr] Last revision date:170616
[St] Status:In-Process

  7 / 1176 MEDLINE  
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[PMID]: 28303065
[Au] Autor:Okumura Y; Takai Y; Yasuda S; Terasaki H
[Ad] Address:Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
[Ti] Title:Bilateral lacrimal caruncle lesions.
[So] Source:Nagoya J Med Sci;79(1):85-90, 2017 Feb.
[Is] ISSN:0027-7622
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:A 65-year-old man was referred to our hospital for the treatment of a lesion on the medial lacrimal canthus of both eyes. He had a history of perinuclear anti-neutrophil cytoplasmic antibodies, i.e., pANCA-positive interstitial pneumonia. Orbital magnetic resonance imaging excluded space occupying lesions, and laboratory testing excluded thyroid-related diseases. The masses were excised, and histopathological examinations showed sebaceous gland hyperplasia and inflammatory changes around the gland. In addition, the specimen from the left eye showed a retention cyst possibly caused by an infection. It was also possible that the use of steroid was involved in the development of the lesions. A relationship between the ANCA and the lesions was not completely eliminated.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1703
[Cu] Class update date: 170319
[Lr] Last revision date:170319
[St] Status:In-Data-Review
[do] DOI:10.18999/nagjms.79.1.85

  8 / 1176 MEDLINE  
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[PMID]: 28267391
[Au] Autor:Shafi F; Rathore D; Johnson A; Mehta P; Ahluwalia HS
[Ad] Address:a University Hospital of Coventry & Warwickshire , Coventry , West Midlands , United Kingdom.
[Ti] Title:Medial canthal defects following tumour excision: To reconstruct or not to reconstruct?
[So] Source:Orbit;36(2):64-68, 2017 Apr.
[Is] ISSN:1744-5108
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Laissez-faire following excision of peri-ocular tumours has been described, but is not universally well established. We describe our experience with laissez-faire for managing medial canthal defects following tumour excision and compare our outcomes with full thickness skin grafts. Retrospective comparative case series of 68 patients who underwent reconstruction of a medial canthal defect using laissez-faire with sutured Sorbsan (LFS) (n = 36) or a full thickness skin graft (FTSG) (n = 32) at the same centre. Tumour diagnosis, defect size, time taken to epithelialise, functional and cosmetic outcomes, complications, follow-up duration and any secondary interventions were recorded. Basal call carcinoma was the most common neoplasm excised (63/68, 93%). Defect size ranged from 7 × 5 mm to 25 × 10 mm. Mean time for wound epithelialisation in LFS group was 33 days. Mean duration of follow-up was 32 months (range 1-80 months) for LFS and 30 months (range 6-60 months) for FTSG. Good functional and cosmetic outcomes were achieved in all 68 patients. Review of clinical photographs showed epicanthic fold in 2 patients and visible scar in 1 patient in the LFS group and 3 cases of hypopigmented scar and 7 hypertrophic scars in the FTSG group. No cases required secondary intervention. There were no cases of postoperative infection. LFS in the medial canthal region is less likely to lead to hypertrophic scarring or cicatricial sequelae compared to FTSG (p = 0.02). Both techniques are associated with excellent functional and aesthetic outcomes even for larger defects.
[Mh] MeSH terms primary: Eyelid Neoplasms/surgery
Lacrimal Apparatus Diseases/surgery
Lacrimal Apparatus/surgery
Ophthalmologic Surgical Procedures/adverse effects
Reconstructive Surgical Procedures/methods
Skin Neoplasms/surgery
Skin Transplantation/methods
[Mh] MeSH terms secundary: Adenocarcinoma, Sebaceous/surgery
Adult
Aged
Aged, 80 and over
Alginates
Bandages
Bowen's Disease/surgery
Carcinoma, Basal Cell/surgery
Carcinoma, Squamous Cell/surgery
Female
Humans
Lacrimal Apparatus/pathology
Lacrimal Apparatus Diseases/etiology
Male
Middle Aged
Retrospective Studies
Suture Techniques
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Alginates); 0 (sorbsan)
[Em] Entry month:1710
[Cu] Class update date: 171006
[Lr] Last revision date:171006
[Js] Journal subset:IM
[Da] Date of entry for processing:170308
[St] Status:MEDLINE
[do] DOI:10.1080/01676830.2017.1279654

  9 / 1176 MEDLINE  
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[PMID]: 28256760
[Au] Autor:Ho J; Bhawan J
[Ad] Address:Department of Dermatology and Section of Dermatopathology, Boston University School of Medicine, Boston, Massachusetts, USA.
[Ti] Title:Folliculosebaceous neoplasms: A review of clinical and histological features.
[So] Source:J Dermatol;44(3):259-278, 2017 Mar.
[Is] ISSN:1346-8138
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Numerous benign and occasionally malignant tumors arise from the folliculosebaceous apparatus. Confusing terminology, rarity of malignant variants and overlapping histological features can lead to diagnostic uncertainty. This review highlights the clinical and histopathological features that help to classify these entities, as well as the various syndromes associated with certain members of this large family of tumors.
[Mh] MeSH terms primary: Hair Diseases/pathology
Hair Follicle/pathology
Sebaceous Glands/pathology
Skin Neoplasms/pathology
[Mh] MeSH terms secundary: Hair Diseases/diagnosis
Hair Follicle/anatomy & histology
Hair Follicle/embryology
Humans
Sebaceous Gland Neoplasms/diagnosis
Sebaceous Gland Neoplasms/pathology
Skin Neoplasms/diagnosis
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1703
[Cu] Class update date: 170306
[Lr] Last revision date:170306
[Js] Journal subset:IM
[Da] Date of entry for processing:170304
[St] Status:MEDLINE
[do] DOI:10.1111/1346-8138.13773

  10 / 1176 MEDLINE  
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[PMID]: 28211590
[Au] Autor:Alegría-Landa V; Jo-Velasco M; Prieto-Torres L; Requena L
[Ad] Address:Department of Dermatology, Fundación Jiménez Diaz, Universidad Autónoma, Madrid, Spain.
[Ti] Title:Genital folliculo-sebaceous cystic hamartoma: A claim of the stroma as a clue in the diagnosis of proliferations with follicular differentiation.
[So] Source:J Cutan Pathol;44(5):504-508, 2017 May.
[Is] ISSN:1600-0560
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Folliculo-sebaceous hamartomas comprise a series of entities whose boundaries are imprecise. We present the clinical case of a folliculo-sebaceous cystic hamartoma of genital localization where the diagnosis was established based on the epithelial proliferation, but mostly, on the characteristic stroma. Because this lesion lacked of the cystic component, we mention the most frequent differential diagnoses and review the literature of the few cases published on this infrequent localization.
[Mh] MeSH terms primary: Genital Diseases, Female
Hamartoma
Sebaceous Gland Diseases
[Mh] MeSH terms secundary: Female
Genital Diseases, Female/diagnosis
Genital Diseases, Female/pathology
Hamartoma/diagnosis
Hamartoma/pathology
Humans
Middle Aged
Sebaceous Gland Diseases/diagnosis
Sebaceous Gland Diseases/pathology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Entry month:1707
[Cu] Class update date: 170721
[Lr] Last revision date:170721
[Js] Journal subset:IM
[Da] Date of entry for processing:170218
[St] Status:MEDLINE
[do] DOI:10.1111/cup.12920


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