Database : MEDLINE
Search on : Sepsis [Words]
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[PMID]: 26937897
[Au] Autor:Zhang GQ; Hu HJ; Liu CY; Shakya S; Li ZY
[Ad] Address:From the Department of Gastroenterology (G-QZ, H-JH, SS, Z-YL) and Department of Nephrology (C-YL), Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Children's Hospital of Chongqing Medical University, Chongqing, China.
[Ti] Title:Probiotics for Preventing Late-Onset Sepsis in Preterm Neonates: A PRISMA-Compliant Systematic Review and Meta-Analysis of Randomized Controlled Trials.
[So] Source:Medicine (Baltimore);95(8):e2581, 2016 Feb.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The effect of probiotics on late-onset sepsis (LOS) in preterm neonates remains controversial. The authors systematically reviewed the literature to investigate whether enteral probiotic supplementation reduced the risk of LOS in preterm neonates in neonatal intensive care units.PubMed, Embase, and Cochrane Central Register of Controlled Trials were systematically searched for randomized controlled trials (RCTs) regarding the effect of probiotics in preterm neonates. The primary outcome was culture-proven bacterial and/or fungal sepsis. The Mantel-Haenszel method with random-effects model was used to calculate pooled relative risks (RRs) and 95% confidence intervals (CIs).Twenty-seven trials were included in our review, and 25 trials involving 6104 preterm neonates were statistically analyzed. Pooled analysis indicated that enteral probiotic supplementation significantly reduced the risk of any sepsis (25 RCTs; RR 0.83, 95% CI 0.73-0.94; I = 26%), bacterial sepsis (11 RCTs; RR 0.82, 95% CI 0.71-0.95; I = 0%), and fungal sepsis (6 RCTs; RR 0.57, 95% CI 0.41-0.78; I = 0%). This beneficial effect remains in very low birth weight infants (<1500 g) (19 RCTs; RR 0.86, 95% CI 0.75-0.97; I = 18%), but not in extremely low birth weight infants (<1000 g) (3 RCTs; RR 0.73, 95% CI 0.45-1.19; I = 53%). All the included trials reported no systemic infection caused by the supplemental probiotic organisms.Current evidence indicates that probiotic supplementation is safe, and effective in reducing the risk of LOS in preterm neonates in neonatal intensive care units. Further studies are needed to address the optimal probiotic organism, dosing, timing, and duration. High-quality and adequately powered RCTs regarding the efficacy and safety of the use of probiotics in extremely low birth weight infants are still warranted.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1603
[Cu] Class update date: 160325
[Lr] Last revision date:160325
[Js] Journal subset:AIM; IM
[St] Status:In-Process
[do] DOI:10.1097/MD.0000000000002581

  2 / 98633 MEDLINE  
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[PMID]: 26703968
[Au] Autor:Chang CY; Chen JY; Chen SH; Cheng TJ; Lin MT; Hu ML
[Ad] Address:Department of Neurology, Chi Mei Medical Center, 901 Chung-Hwa Road, Yong kang, Tainan, Taiwan; Department of Food Science and Applied Biotechnology, National Chung-Hsing University, 250 Kuo-Kuang Road, Taichung 402, Taiwan; Center for General Education, Southern Taiwan University of Science and Tec...
[Ti] Title:Therapeutic treatment with ascorbate rescues mice from heat stroke-induced death by attenuating systemic inflammatory response and hypothalamic neuronal damage.
[So] Source:Free Radic Biol Med;93:84-93, 2016 Apr.
[Is] ISSN:1873-4596
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The impact of ascorbate on oxidative stress-related diseases is moderate because of its limited oral bioavailability and rapid clearance. However, recent evidence of the clinical benefit of parenteral vitamin C administration has emerged, especially in critical care. Heatstroke is defined as a form of excessive hyperthermia associated with a systemic inflammatory response that results in multiple organ dysfunctions in which central nervous system disorders such as delirium, convulsions, and coma are predominant. The thermoregulatory, immune, coagulation and tissue injury responses of heatstroke closely resemble those observed during sepsis and are likely mediated by similar cellular mechanisms. This study was performed by using the characteristic high lethality rate and sepsis-mimic systemic inflammatory response of a murine model of heat stroke to test our hypothesis that supra-physiological doses of ascorbate may have therapeutic use in critical care. We demonstrated that parenteral administration of ascorbate abrogated the lethality and thermoregulatory dysfunction in murine model of heat stroke by attenuating heat stroke-induced accelerated systemic inflammatory, coagulation responses and the resultant multiple organ injury, especially in hypothalamus. Overall, our findings support the hypothesis and notion that supra-physiological doses of ascorbate may have therapeutic use in critical care.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1603
[Js] Journal subset:IM
[St] Status:In-Process

  3 / 98633 MEDLINE  
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[PMID]: 26637651
[Au] Autor:Syrengelas D; Kalampoki V; Kleisiouni P; Manta V; Mellos S; Pons R; Chrousos GP; Siahanidou T
[Ad] Address:D. Syrengelas, PT, MSc, Department of Pediatric Physical Therapy, Aghia Sophia Children's Hospital, Athens 11527, Greece. syreggelas@yahoo.com....
[Ti] Title:Alberta Infant Motor Scale (AIMS) Performance of Greek Preterm Infants: Comparisons With Full-Term Infants of the Same Nationality and Impact of Prematurity-Related Morbidity Factors.
[So] Source:Phys Ther;96(7):1102-8, 2016 Jul.
[Is] ISSN:1538-6724
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Only a few studies have been conducted with the objective of creating norms of the Alberta Infant Motor Scale (AIMS) for the assessment of gross motor development of preterm infants. The AIMS performance of preterm infants has been compared with that of the Canadian norms of full-term infants, but not with that of full-term infants of the same nationality. Moreover, the possible impact of prematurity-related morbidity factors on AIMS performance is unknown. OBJECTIVES: The aims of this study were: (1) to evaluate AIMS trajectory in a large population of Greek preterm infants and create norms, (2) to compare it with the AIMS trajectory of Greek full-term infants, and (3) to examine the possible influence of neonatal morbidity on AIMS scores in the preterm sample. DESIGN: This was a cross-sectional study. METHODS: Mean AIMS scores were compared, per month (1-19), between 403 preterm infants (≤32 weeks of age, corrected for prematurity) and 1,038 full-term infants. In preterm infants, the association of AIMS scores with respiratory distress syndrome (RDS), intraventricular hemorrhage (IVH) of grade ≤III, bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), and sepsis was assessed by hierarchical regression analysis. RESULTS: Alberta Infant Motor Scale scores were significantly lower in preterm infants than in full-term infants. Mean AIMS scores in preterm infants were significantly associated with RDS (b=-1.93; 95% CI=-2.70, -1.16), IVH (b=-0.97; 95% CI=-1.69, -0.25), and ROP (b=-1.12; 95% CI=-1.99, -0.24) but not with BPD or sepsis in hierarchical regression analysis. CONCLUSIONS: Alberta Infant Motor Scale norms were created for Greek preterm infants. This study confirms that AIMS trajectories of preterm infants are below those of full-term infants of the same nationality. The influence of morbidity factors, including RDS, IVH, and ROP, should be taken into account when administering the AIMS in preterm infants.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1607
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review
[do] DOI:10.2522/ptj.20140494

  4 / 98633 MEDLINE  
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[PMID]: 27368016
[Au] Autor:Azab SF; Abdalhady MA; Elsaadany HF; Elkomi MA; Elhindawy EM; Sarhan DT; Salam MM; Allah MA; Emam AA; Noah MA; Abdelsalam NI; Abdellatif SH; Rass AA; Ismail SM; Gheith T; Aziz KA; Hamed ME; Abdelrahman HM; Ahmed AR; Nabil RM; Abdulmaksoud RS; Yousef HY
[Ad] Address:Faculty of Medicine, Zagazig University, Egypt.
[Ti] Title:Interleukin-10 -1082 G/A gene polymorphisms in Egyptian children with CAP: A case-control study.
[So] Source:Medicine (Baltimore);95(26):e4013, 2016 Jun.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Community-acquired pneumonia (CAP) is one of the leading causes of death worldwide. Cytokines are involved in the pathogenesis of CAP. To date, only a few studies concerned the association of interleukin-10 (IL-10) gene polymorphisms with CAP.In this study, we aimed to investigate whether the -1082(G/A) polymorphism in the promoter region of the IL-10 gene is involved in susceptibility to and the outcome of CAP, and we also measured the serum level of IL-10 to assess its relation to such polymorphism.This was a case-control study included 100 patients with CAP, and matched with age, gender, and ethnicity of 100 healthy control children. IL-10 -1082(G/A) gene polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism, while the serum IL-10 levels were measured by ELISA method.Compared to the controls subjects, the frequencies of the IL-10 -1082 AA genotype and A allele were observed to be overrepresented in patients with CAP (51%; odds ratio [OR] = 2.8; 95% confidence interval [CI]: 1.5-5.3 for the AA genotype; P < 0.01) and (70%; OR: 1.95; 95% CI: 1.27-3.00 for the A allele; P < 0.01, respectively). We found that patients with the GG genotype had significantly higher serum IL-10 levels (46.7  9.5 pg/mL) compared to those with AG genotype (21.8  4.5 pg/mL) and AA genotype (11.5  3.3 pg/mL); P < 0.01, respectively. Our data revealed a significant positive association between the -1082 GG genotype and susceptibility to severe sepsis, acute respiratory failure, and hospital mortality (OR: 3.8; 95% CI: 1.3-11.2; P < 0.01).We demonstrate for the first time, to the best of our knowledge, that IL-10 -1082 (G/A) gene polymorphism may contribute to susceptibility to CAP in Egyptian children. Moreover, we observed that the presence of a G allele or GG genotype at the -1082 position of the promoter region of the IL-10 gene constitute risk factors for developing severe sepsis, acute respiratory failure, and hospital mortality among patients with CAP.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1607
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review
[do] DOI:10.1097/MD.0000000000004013

  5 / 98633 MEDLINE  
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[PMID]: 27357410
[Au] Autor:Marco D; Carlo S; Sara C; Carmelina C; Silvia G; Maria BA; Silvia B; Pier-Angelo T; Regina Margherita Children's Hospital Bloodstream Infections Study Group participants
[Ad] Address:Department of Pediatrics, Infectious Diseases Unit, Regina Margherita Children' s Hospital, University of Turin, Piazza Polonia 94, Turin, 10126, Italy. marco.denina@gmail.com....
[Ti] Title:Magicplex(TM) Sepsis Real-Time test to improve bloodstream infection diagnostics in children.
[So] Source:Eur J Pediatr;175(8):1107-11, 2016 Aug.
[Is] ISSN:1432-1076
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:UNLABELLED: Sepsis is the major cause of morbidity and mortality in children, especially in immunocompromised patients, and a rapid identification of causative pathogen is strongly related with a better outcome. This prospective study analyzes the role of a multiplex real-time polymerase chain reaction in sepsis' etiological diagnosis. Magicplex(TM) Sepsis Real-Time tests were performed in tertiary Regina Margherita Children's Hospital (Turin, Italy), and the medical records of children who underwent a Magicplex test were prospectively evaluated. Results of the Magicplex test were compared with those of blood culture collected at a close time point. One hundred fifty Magicplex tests were collected from 89 patients (54 males and 35 females, age interquartile range: 2.6-12.1years). Etiological definition was achieved in 60 bloodstream infection cases (40%). In 32 episodes, Magicplex test alone gave a positive result, and blood culture alone permitted the etiological diagnosis in 5 septic episodes. Magicplex test allowed a 143% increase in the diagnostic value of blood cultures. CONCLUSION: These results suggest that molecular biology can be useful for rapid pathogen's identification also in children. WHAT IS KNOWN: • Sepsis represents a major cause of morbidity and mortality in children. • Sepsis outcome is strongly related to rapid microbiological identification and prompt initiation of an appropriate chemotherapy. What is New: • This manuscript is the first that describes the use of Magicplex (TM) Sepsis Real-Time test in children. • The results suggest that molecular biology can be useful for rapid pathogen's identification also in children.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1607
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s00431-016-2745-3

  6 / 98633 MEDLINE  
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[PMID]: 27180634
[Au] Autor:Eckerle M; Lahni P; Wong H
[Ad] Address:a Division of Emergency Medicine , Cincinnati Children's Hospital Medical Center , Cincinnati , OH , USA ....
[Ti] Title:Estimating the probability of bacterial infection using a novel biomarker among pediatric patients in the emergency department.
[So] Source:Biomarkers;21(5):404-8, 2016 Jul.
[Is] ISSN:1366-5804
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:CONTEXT: IL-27 is a novel biomarker to identify bacterial infection in children. OBJECTIVE: IL-27 was evaluated among pediatric emergency department (ED) patients and compared with procalcitonin (PCT). METHODS AND RESULTS: Children undergoing blood, urine, or cerebrospinal fluid cultures had IL-27 and PCT assays performed. Bacterial infection was defined as a positive culture or a clinical diagnosis based on chart review. IL-27 and PCT were increased among patients with bacterial infection and demonstrated comparable AUC's (0.62 versus 0.61). A decision tree incorporating IL-27, PCT, and white blood cell count improved the AUC (0.80). CONCLUSION: IL-27 is a viable candidate biomarker to identify bacterial infection among ED patients and is comparable with PCT.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1607
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.3109/1354750X.2015.1118538

  7 / 98633 MEDLINE  
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[PMID]: 27367886
[Au] Autor:Dres M; Mancebo J; Curley GF
[Ad] Address:1 Department of Critical Care, St. Michael's Hospital and the Critical Illness and Injury Research Centre, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, Ontario, Canada....
[Ti] Title:Update in Critical Care 2015.
[So] Source:Am J Respir Crit Care Med;194(1):19-25, 2016 Jul 1.
[Is] ISSN:1535-4970
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:This review documents important progress made in 2015 in the field of critical care. Significant advances in 2015 included further evidence for early implementation of low tidal volume ventilation as well as new insights into the role of open lung biopsy, diaphragmatic dysfunction, and a potential mechanism for ventilator-induced fibroproliferation. New therapies, including a novel low-flow extracorporeal CO2 removal technique and mesenchymal stem cell-derived microparticles, have also been studied. Several studies examining the role of improved diagnosis and prevention of ventilator-associated pneumonia also showed relevant results. This review examines articles published in the American Journal of Respiratory and Critical Care Medicine and other major journals that have made significant advances in the field of critical care in 2015.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1607
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review
[do] DOI:10.1164/rccm.201602-0339UP

  8 / 98633 MEDLINE  
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[PMID]: 27166972
[Au] Autor:Corts-Puch I; Hartog CS
[Ad] Address:1 Critical Care Medicine Department National Institutes of Health Bethesda, Maryland.
[Ti] Title:Opening the Debate on the New Sepsis Definition Change Is Not Necessarily Progress: Revision of the Sepsis Definition Should Be Based on New Scientific Insights.
[So] Source:Am J Respir Crit Care Med;194(1):16-8, 2016 Jul 1.
[Is] ISSN:1535-4970
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1607
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review
[do] DOI:10.1164/rccm.201604-0734ED

  9 / 98633 MEDLINE  
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[PMID]: 27166833
[Au] Autor:Angus DC
[Ad] Address:1 Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania.
[Ti] Title:Opening the Debate on the New Sepsis Definition Defining Sepsis: A Case of Bounded Rationality and Fuzzy Thinking?
[So] Source:Am J Respir Crit Care Med;194(1):14-5, 2016 Jul 1.
[Is] ISSN:1535-4970
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1607
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review
[do] DOI:10.1164/rccm.201604-0879ED

  10 / 98633 MEDLINE  
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[PMID]: 27106039
[Au] Autor:Miranda M; Balarini M; Caixeta D; Bouskela E
[Ad] Address:Laboratory for Clinical and Experimental Research in Vascular Biology, BioVasc, Biomedical Center, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil; marcoslmiranda@gmail.com....
[Ti] Title:Microcirculatory dysfunction in sepsis: pathophysiology, clinical monitoring, and potential therapies.
[So] Source:Am J Physiol Heart Circ Physiol;311(1):H24-35, 2016 Jul 1.
[Is] ISSN:1522-1539
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Abnormal microvascular perfusion, including decreased functional capillary density and increased blood flow heterogeneity, is observed in early stages of the systemic inflammatory response to infection and appears to have prognostic significance in human sepsis. It is known that improvements in systemic hemodynamics are weakly correlated with the correction of microcirculatory parameters, despite an appropriate treatment of macrohemodynamic abnormalities. Furthermore, conventional hemodynamic monitoring systems available in clinical practice fail to detect microcirculatory parameter changes and responses to treatments, as they do not evaluate intrinsic events that occur in the microcirculation. Fortunately, some bedside diagnostic methods and therapeutic options are specifically directed to the assessment and treatment of microcirculatory changes. In the present review we discuss fundamental aspects of septic microcirculatory abnormalities, including pathophysiology, clinical monitoring, and potential therapies.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1607
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1152/ajpheart.00034.2016


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