Database : MEDLINE
Search on : Sepsis [Words]
References found : 90345 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 9035 go to page                         

  1 / 90345 MEDLINE  
              next record last record
select
to print
Photocopy
Full text

[PMID]: 25241107
[Au] Autor:Horton AL; Lai Y; Rouse DJ; Spong CY; Leveno KJ; Varner MW; Mercer BM; Iams JD; Wapner RJ; Sorokin Y; Thorp JM; Ramin SM; Malone FD; O'Sullivan MJ; Hankins GD; Caritis SN; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
[Ad] Address:Department of Obstetrics and Gynecology, NorthShore University Health System, Evanston, Illinois....
[Ti] Title:Effect of magnesium sulfate administration for neuroprotection on latency in women with preterm premature rupture of membranes.
[So] Source:Am J Perinatol;32(4):387-92, 2015 Mar.
[Is] ISSN:1098-8785
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Objective This study aims to evaluate whether magnesium sulfate administration for neuroprotection prolongs latency in women with preterm premature rupture of membranes (PPROM) between 24 and 31(6/7) weeks' gestation. Study Design This is a secondary analysis of a randomized controlled trial of magnesium sulfate for prevention of cerebral palsy. Gravid women with a singleton pregnancy between 24 and 31(6/7) weeks' gestation with PPROM without evidence of labor were randomized to receive magnesium sulfate, administered intravenously as a 6-g bolus followed by a constant infusion of 2 g per hour up to 12 hours, or placebo. Maternal outcomes for this analysis were delivery in less than 48 hours and in less than 7 days from randomization. Neonatal outcomes included a composite of respiratory distress syndrome, interventricular hemorrhage grades 3 or 4, periventricular leukomalacia, sepsis, necrotizing enterocolitis, retinopathy of prematurity, or death. Results A total of 1,259 women were included. The rate of delivery < 48 hours was not different in the magnesium sulfate and the placebo groups (22.2 and 20.7%, p = 0.51). Delivery < 7 days was similar between groups (55.4 and 51.4%, p = 0.16). Median latency was also similar between groups (median [interquartile range], 6.0 days [range, 2.4-13.8 days] and 6.6 days [range, 2.4-15.1 days], p = 0.29). Composite neonatal outcomes did not differ between groups. Conclusion Magnesium sulfate administration given for neuroprotection in women with a singleton gestation with PPROM and without labor before 32 weeks does not impact latency.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Cu] Class update date: 150321
[Lr] Last revision date:150321
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1055/s-0034-1387930

  2 / 90345 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
PubMed Central Full text
Full text

[PMID]: 25789245
[Au] Autor:Pian Y; Wang P; Liu P; Zheng Y; Zhu L; Wang H; Xu B; Yuan Y; Jiang Y
[Ad] Address:State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing Institute of Microbiology and Epidemiology Beijing China....
[Ti] Title:Proteomics identification of novel fibrinogen-binding proteins of Streptococcus suis contributing to antiphagocytosis.
[So] Source:Front Cell Infect Microbiol;5:19, 2015.
[Is] ISSN:2235-2988
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Streptococcus suis serotype 2 (SS2) induced sepsis and meningitis are often accompanied by bacteremia. However, the mechanism whereby it helps S. suis to evade PMN-mediated phagocytosis remain unclear. Because of the central roles of bacteria-human fibrinogen (hFg) interaction in innate immunity, here, a proteomics based Far-western blotting (PBFWB) was developed to identify the fibrinogen-binding surface proteins of S. suis (SsFBPs) on a large-scale. And then thirteen potential SsFBPs were identified by PBFWB and we selected seven potential surface proteins to further confirm their binding ability to hFg, of which the gene mutant strains of MRP displayed significantly decrease in binding to immobilized hFg. Additionally, the polyclonal antibodies against Enolase were found to significantly inhibit the binding of SS2 to hFg. Strikingly, MRP and Enolase were found to improve the antiphagocytic ability of SS2 to PMNs by interacting with hFg and enhance the survival of SS2 in human blood. Taken together, the PBFWB method provides useful clues to the bacteria-host interactions. These studies firstly disclose MRP and Enolase were involved in immune evasion of SS2 at least in part by binding to Fg, which make them potential targets for therapies for SS2 infection.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Cu] Class update date: 150321
[Lr] Last revision date:150321
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.3389/fcimb.2015.00019

  3 / 90345 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
PubMed Central Full text

[PMID]: 25785118
[Au] Autor:Tian H; Zhang M; Du C; Li D; Zhou Q; Wu L; Meng F; Song S; Wang L; Lu P; Zhao Z; Yang X
[Ad] Address:Department of Intensive Medicine, First Hospital of Hebei Medical University China....
[Ti] Title:Effects of Rhubarb combined with ulinastatin on T-cell subsets in sepsis rats.
[So] Source:Int J Clin Exp Med;8(1):1234-40, 2015.
[Is] ISSN:1940-5901
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: The pathogenesis of sepsis, a systemic inflammatory response syndrome, is very complicated and not well understood. However, the importance of lymphocyte percentage and ratio is implicated. Rhubarb is a traditional Chinese medication and plays a role in protecting gastrointestinal mucous and controlling the SIRS damage. Ulinastatin is a protease inhibitor that prevents overproduction of inflammatory cytokines. Currently, despite numerous sepsis clinical researches, the study on the effects of combined drug therapy on sepsis is lacking. In this study, we studied Rhubarb and Ulinastatin combination treatment on T lymphocyte subsets in sepsis induced by the cecal ligation and perforation (CLP). Immunosuppression happened at the early stage of severe sepsis in the CLP rat models, as CD3(+), CD4(+), CD4(+)/CD8(+) began to decline, dropped rapidly after 24 h and continuously decreased at 36 h. CD8(+) T lymphocyte showed no significant change in all groups after CLP. The morality of CLP rats was increased with Rhubarb treatment in test dose (1.2 g/100 g). The immunosuppression state of CLP rats ameliorated with UTI treatment at early stage. The immunomodulatory properties were improved along with drug treatment, and immunities were obviously increased after 24 h, moreover, continuously increased at 36 h. The relief effect of immunosuppression after CLP showed much better in Rhubarb combined with UTI treatment than UTI monotherapy. In conclusion, the combination drug treatment facilitates the improvement of sepsis by modifying the lymphocyte percentage.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Cu] Class update date: 150321
[Lr] Last revision date:150321
[Da] Date of entry for processing:150318
[St] Status:PubMed-not-MEDLINE

  4 / 90345 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
PubMed Central Full text
Full text

[PMID]: 25784782
[Au] Autor:Imanishi M; Routh JA; Klaber M; Gu W; Vanselow MS; Jackson KA; Sullivan-Chang L; Heinrichs G; Jain N; Albanese B; Callaghan WM; Mahon BE; Silk BJ
[Ad] Address:Division of Foodborne, Waterborne, and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA ; Epidemic Intelligence Service, Scientific Education and Professional Development Program Office, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA....
[Ti] Title:Estimating the Attack Rate of Pregnancy-Associated Listeriosis during a Large Outbreak.
[So] Source:Infect Dis Obstet Gynecol;2015:201479, 2015.
[Is] ISSN:1098-0997
[Cp] Country of publication:Egypt
[La] Language:eng
[Ab] Abstract:Background. In 2011, a multistate outbreak of listeriosis linked to contaminated cantaloupes raised concerns that many pregnant women might have been exposed to Listeria monocytogenes. Listeriosis during pregnancy can cause fetal death, premature delivery, and neonatal sepsis and meningitis. Little information is available to guide healthcare providers who care for asymptomatic pregnant women with suspected L. monocytogenes exposure. Methods. We tracked pregnancy-associated listeriosis cases using reportable diseases surveillance and enhanced surveillance for fetal death using vital records and inpatient fetal deaths data in Colorado. We surveyed 1,060 pregnant women about symptoms and exposures. We developed three methods to estimate how many pregnant women in Colorado ate the implicated cantaloupes, and we calculated attack rates. Results. One laboratory-confirmed case of listeriosis was associated with pregnancy. The fetal death rate did not increase significantly compared to preoutbreak periods. Approximately 6,500-12,000 pregnant women in Colorado might have eaten the contaminated cantaloupes, an attack rate of ~1 per 10,000 exposed pregnant women. Conclusions. Despite many exposures, the risk of pregnancy-associated listeriosis was low. Our methods for estimating attack rates may help during future outbreaks and product recalls. Our findings offer relevant considerations for management of asymptomatic pregnant women with possible L. monocytogenes exposure.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Cu] Class update date: 150321
[Lr] Last revision date:150321
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1155/2015/201479

  5 / 90345 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
PubMed Central Full text
Full text

[PMID]: 25777902
[Au] Autor:Yoshimura J; Yamakawa K; Ogura H; Umemura Y; Takahashi H; Morikawa M; Inoue Y; Fujimi S; Tanaka H; Hamasaki T; Shimazu T
[Ad] Address:Department of Emergency and Critical Care, Osaka General Medical Center, 3-1-56 Bandai-Higashi, Sumiyoshi-ku, Osaka, 558-8558, Japan, jumpei.y0210@gmail.com.
[Ti] Title:Benefit profile of recombinant human soluble thrombomodulin in sepsis-induced disseminated intravascular coagulation: a multicenter propensity score analysis.
[So] Source:Crit Care;19(1):810, 2015 Dec.
[Is] ISSN:1466-609X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:INTRODUCTION: The safety and efficacy of recombinant human soluble thrombomodulin (rhTM) have been demonstrated, with promising evidence suggestive of efficacy for patients with severe sepsis involving coagulopathy in a phase IIb randomized controlled trial. However, the benefit profiles of rhTM have not been elucidated. The purpose of this study was to explore whether patients with greater disease severity, determined according to the Acute Physiology and Chronic Health Evaluation (APACHE) II and Sequential Organ Failure Assessment (SOFA) scores, would experience treatment benefit from rhTM administration. METHODS: This was a post hoc, subgroup analysis of a multicenter retrospective cohort study conducted in three Japanese tertiary referral hospitals. Patients with sepsis-induced disseminated intravascular coagulation (DIC) who required ventilator management were included. We stratified patients into several strata according to disease severity, determined by APACHE II and SOFA scores, using classification and regression trees for survival data. Intervention effects, expressed as hazard ratios (HR), were analyzed using Cox regression analysis adjusted for a propensity model to detect subgroup heterogeneity of the effects of rhTM on in-hospital mortality. RESULTS: Participants were 162 patients with sepsis-induced DIC; 68 of these patients received rhTM and 94 did not. After adjusting for imbalances, rhTM administration was significantly associated with reduced mortality in high-risk patients (APACHE II: 24 to 29; HR: 0.281; 95% confidence interval (CI): 0.093 to 0.850; P = 0.025). A similar nonsignificant tendency was observed in the very high-risk subset (APACHE II: ≥30; HR: 0.529; 95% CI: 0.202 to 1.387; P = 0.195) but was not evident in the moderate-risk subset of patients (APACHE II: <24; HR: 0.814; 95% CI: 0.351 to 1.884; P = 0.630). A similar tendency was observed in analysis of SOFA scores (moderate-risk subset (SOFA: <11), P = 0.368; high-risk subset (SOFA: ≥11), P = 0.042). CONCLUSIONS: Survival benefit was observed with rhTM treatment in sepsis-induced DIC and high risk of death according to baseline APACHE II and SOFA scores.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Cu] Class update date: 150321
[Lr] Last revision date:150321
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1186/s13054-015-0810-3

  6 / 90345 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
PubMed Central Full text
Full text

[PMID]: 25312048
[Au] Autor:Pei Z; Wang J
[Ad] Address:Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, PR China.
[Ti] Title:Propofol attenuates LPS-induced tumor necrosis factor-α, interleukin-6 and nitric oxide expression in canine peripheral blood mononuclear cells possibly through down-regulation of nuclear factor (NF)-κB activation.
[So] Source:J Vet Med Sci;77(2):139-45, 2015 Mar 1.
[Is] ISSN:1347-7439
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:Sepsis is a major cause of mortality in intensive care medicine. Propofol, an intravenous general anesthetic, has been suggested to have anti-inflammatory properties and able to prevent sepsis induced by Gram-positive and Gram-negative bacteria by down-regulating the gene expression of pro-inflammatory cytokines. However, propofol's anti-inflammatory effects upon canine peripheral blood mononuclear cells (PBMCs) have not yet been clarified. Here, we isolate canine PBMCs and investigate the effects of propofol on the gene expressions of both lipopolysaccharide (LPS)-induced interleukin-6 (IL-6) and tumor necrosis factor (TNF)-α and upon the production of nitric oxide (NO). Through real-time quantitative PCR and the Griess reagent system, we found that non-cytotoxic levels of propofol significantly inhibited the release of NO and IL-6 and TNF-α gene expression in LPS-induced canine PBMCs. Western blotting revealed that LPS does significantly increase the expression of inducible NO synthase (iNOS) protein in canine PBMCs, while pretreatment with propofol significantly decreases the LPS-induced iNOS protein expression. Propofol, at concentration of 25 M and 50 M, also significantly inhibited the LPS-induced nuclear translocation of nuclear factor (NF)-κB p65 protein in canine PBMCs. This diminished TNF-α, IL-6 and iNOS expression, and NO production was in parallel to the respective decreased NF-κB p65 protein nuclear translocation in the LPS-activated canine PBMCs pretreated with 25 M and 50 M propofol. This suggests that non-cytotoxic levels of propofol pretreatment can down-regulate LPS-induced inflammatory responses in canine PBMCs, possibly by inhibiting the nuclear translocation of the NF-κB p65 protein.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Cu] Class update date: 150321
[Lr] Last revision date:150321
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1292/jvms.14-0212

  7 / 90345 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 25343711
[Au] Autor:Kulkova N; Babalova M; Sokolova J; Krcmery V
[Ad] Address:1 Laboratory of Molecular Microbiology, St. Elisabeth University , Bratislava, Slovakia .
[Ti] Title:First report of New Delhi metallo--lactamase-1-producing strains in Slovakia.
[So] Source:Microb Drug Resist;21(1):117-20, 2015 Feb.
[Is] ISSN:1931-8448
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Occurrence of carbapenemase-producing organisms, including New Delhi metallo--lactamase-1 (NDM-1) is increasingly reported worldwide. The aim of this study was to assess the distribution of carbapenemase producers among multidrug-resistant Gram-negative bacteria isolated from blood cultures. All carbapenem-resistant strains collected from December 2011 to December 2012 were analyzed. Presence of carbapenemases was assessed with combined disc test and Carba NP test followed by polymerase chain reaction for carbapenemase genes. Altogether, 30 strains were detected, of which 7 were positive for VIM (23.3%), 6 for NDM-1 (20%), 5 for IMP (16.7%), and KPC was present in one isolate (3.3%). Four Pseudomonas aeruginosa strains were found to produce more than one carbapenemase. We also present the case report of a patient with Acinetobacter baumannii ventilator-associated pneumonia, followed by sepsis due to Enterococcus faecalis and pan-resistant NDM-1-producing P. aeruginosa. Despite the inappropriate therapy, the patient was successfully treated. This is the first report of NDM-1-producing strains in Slovakia and it contributes to a number of studies mapping the distribution of carbapenemase producers in Europe.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1502
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1089/mdr.2013.0162

  8 / 90345 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 25218136
[Au] Autor:Laufenberg LJ; Pruznak AM; Navaratnarajah M; Lang CH
[Ad] Address:Departments of Cellular and Molecular Physiology (H166), and Surgery, Penn State College of Medicine, Hershey, PA, 17033, USA.
[Ti] Title:Sepsis-induced changes in amino acid transporters and leucine signaling via mTOR in skeletal muscle.
[So] Source:Amino Acids;46(12):2787-98, 2014 Dec.
[Is] ISSN:1438-2199
[Cp] Country of publication:Austria
[La] Language:eng
[Ab] Abstract:The present study tested the hypothesis that sepsis-induced leucine (Leu) resistance in skeletal muscle is associated with a down-regulation of amino acid transporters important in regulating Leu flux or an impairment in the formation of the Leu-sensitive mTOR-Ragulator complex. Sepsis in adult male rats decreased basal protein synthesis in gastrocnemius, associated with a reduction in mTOR activation as indicated by decreased 4E-BP1 and S6K1 phosphorylation. The ability of oral Leu to increase protein synthesis and mTOR kinase after 1 h was largely prevented in sepsis. Sepsis increased CAT1, LAT2 and SNAT2 mRNA content two- to fourfold, but only the protein content for CAT1 (20 % decrease) differed significantly. Conversely, sepsis decreased the proton-assisted amino acid transporter (PAT)-2 mRNA by 60 %, but without a coordinate change in PAT2 protein. There was no sepsis or Leu effect on the protein content for RagA-D, LAMTOR-1 and -2, raptor, Rheb or mTOR in muscle. The binding of mTOR, PRAS40 and RagC to raptor did not differ for control and septic muscle in the basal condition; however, the Leu-induced decrease in PRAS40raptor and increase in RagCraptor seen in control muscle was absent in sepsis. The intracellular Leu concentration was increased in septic muscle, compared to basal control conditions, and oral Leu further increased the intracellular Leu concentration similarly in both control and septic rats. Hence, while alterations in select amino acid transporters are not associated with development of sepsis-induced Leu resistance, the Leu-stimulated binding of raptor with RagC and the recruitment of mTOR/raptor to the endosome-lysosomal compartment may partially explain the inability of Leu to fully activate mTOR and muscle protein synthesis.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Entry month:1411
[Cu] Class update date: 150321
[Lr] Last revision date:150321
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1007/s00726-014-1836-6

  9 / 90345 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 25795494
[Au] Autor:Chawla LS
[Ad] Address:Department of Medicine Veterans Affairs Medical Center Washington, DC.
[Ti] Title:Introduction: Sepsis-Associated AKI.
[So] Source:Semin Nephrol;35(1):1, 2015 Jan.
[Is] ISSN:1558-4488
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:EDITORIAL
[Em] Entry month:1503
[Js] Journal subset:IM
[St] Status:In-Data-Review

  10 / 90345 MEDLINE  
              first record previous record
select
to print
Photocopy
Full text

[PMID]: 25466727
[Au] Autor:Mokra D; Kosutova P
[Ad] Address:Department of Physiology, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Mala Hora 4, Martin SK-03601, Slovakia. Electronic address: mokra@jfmed.uniba.sk.
[Ti] Title:Biomarkers in acute lung injury.
[So] Source:Respir Physiol Neurobiol;209:52-8, 2015 Apr.
[Is] ISSN:1878-1519
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Acute respiratory distress syndrome (ARDS) and its milder form acute lung injury (ALI) may result from various diseases and situations including sepsis, pneumonia, trauma, acute pancreatitis, aspiration of gastric contents, near-drowning etc. ALI/ARDS is characterized by diffuse alveolar injury, lung edema formation, neutrophil-derived inflammation, and surfactant dysfunction. Clinically, ALI/ARDS is manifested by decreased lung compliance, severe hypoxemia, and bilateral pulmonary infiltrates. Severity and further characteristics of ALI/ARDS may be detected by biomarkers in the plasma and bronchoalveolar lavage fluid (or tracheal aspirate) of patients. Changed concentrations of individual markers may suggest injury or activation of the specific types of lung cells-epithelial or endothelial cells, neutrophils, macrophages, etc.), and thereby help in diagnostics and in evaluation of the patient's clinical status and the treatment efficacy. This chapter reviews various biomarkers of acute lung injury and evaluates their usefulness in diagnostics and prognostication of ALI/ARDS.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Js] Journal subset:IM
[St] Status:In-Data-Review


page 1 of 9035 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information