Database : MEDLINE
Search on : Sepsis [Words]
References found : 100793 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 10080 go to page                         

  1 / 100793 MEDLINE  
              next record last record
select
to print
Photocopy

[PMID]: 27796938
[Au] Autor:Qureshi IN; David D; Thangaraj KR; Kurien RT; Chowdhury SD; Goel A; Dutta AK; Simon EG; Ramachandran A; Balasubramanian KA; Joseph AJ
[Ad] Address:Department of Gastroenterology, Division of Gastrointestinal Sciences, Christian Medical College Hospital, Vellore, 632 004, India.
[Ti] Title:Plasma hydrogen sulphide does not predict severity of acute pancreatitis in humans.
[So] Source:Indian J Gastroenterol;, 2016 Oct 29.
[Is] ISSN:0975-0711
[Cp] Country of publication:India
[La] Language:ENG
[Ab] Abstract:The primary aim of this study was to assess the usefulness of plasma hydrogen sulphide (H2S) level at admission as a predictor of severity of acute pancreatitis. The secondary aims were to examine whether the level of H2S after 48 h correlated with severity and whether level of H2S correlated with pulmonary, renal or infectious complications. Plasma hydrogen sulphide was measured within 24 h of admission and 48 h later, in patients with acute pancreatitis. Patients were classified as having mild or severe pancreatitis, and H2S levels in the two groups were compared. A total of 55 patients had H2S estimation carried out within 24 h of admission. H2S levels were similar in patients with mild (mean 31.8 ± 18.8, range 7.1 to 81.4 µmol/L) and severe pancreatitis (mean 28.2 ± 21.6, range 6.1 to 74.4 µmol/L; p = 0.339). There was no difference found between the groups after 48 h (mild n = 28, mean 26.8 ± 19.4 µmol/L, and severe n = 20, mean 34.6 ± 21.0 µmol/L; p = 0.127). There was also no difference in the levels between patients with or without lung injury, kidney injury or sepsis. Performing H2S estimation to predict severity in acute pancreatitis is not beneficial.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161031
[Lr] Last revision date:161031
[St] Status:Publisher

  2 / 100793 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy

[PMID]: 27796742
[Au] Autor:Catalão CH; Santos-Júnior NN; da Costa LH; Souza AO; Alberici LC; Rocha MJ
[Ad] Address:Department of Neurosciences and Behavioral Sciences of Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
[Ti] Title:Brain Oxidative Stress During Experimental Sepsis Is Attenuated by Simvastatin Administration.
[So] Source:Mol Neurobiol;, 2016 Oct 28.
[Is] ISSN:1559-1182
[Cp] Country of publication:United States
[La] Language:ENG
[Ab] Abstract:During sepsis, brain damage is associated with oxidative stress due to overproduction of reactive oxygen species (ROS). Although there are recent reports about the benefits of statins in experimental sepsis and endotoxemia in peripheral organs, little is known about their effects in the CNS. Here, we investigated the antioxidant properties of simvastatin and its possible neuroprotective role during experimental sepsis. Male Wistar rats (250-300 g) were submitted to cecal ligation and puncture (CLP, n = 34) or remained as non-manipulated (naive, n = 34). Both groups were treated by gavage with simvastatin (20 mg/kg) or an equivalent volume of saline. The animals submitted to CLP were treated 4 days before and 48 h after surgery. One animal group was decapitated and the blood and brain were collected to quantify plasma levels of cytokines and assess astrogliosis and apoptosis in the prefrontal cortex and hippocampus. Another group was perfused with PBS (0.01 M), and the same brain structures were dissected to analyze oxidative damage. The CLP rats treated with simvastatin showed a reduction in nitric oxide (P < 0.05), IL1-ß (P < 0.001), IL-6 (P < 0.01), and TBARS levels (P < 0.001) and an increase in catalase activity (P < 0.01), citrate synthase enzyme (P < 0.05), and normalized GSH/GSSG ratio. In addition, the histopathological analysis showed a reduction (P < 0.001) in reactive astrocytes and caspase 3-positive apoptotic cells. The results suggest a possible neuroprotective effect of simvastatin in structures responsible for spatial learning and memory and indicate the need for behavioral studies evaluating the impact on cognitive damage, as frequently seen in patients surviving sepsis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161031
[Lr] Last revision date:161031
[St] Status:Publisher

  3 / 100793 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy

[PMID]: 27796667
[Au] Autor:Heffernan DS; Monaghan SF; Ayala A
[Ad] Address:Division of Surgical Research, Department of Surgery, Warren Alpert Medical School of Brown UniversityRhode Island Hospital, 211 Aldrich Building, 593 Eddy Street, Providence, 02903, RI, USA. DHeffernan@Brown.edu.
[Ti] Title:Lymphocyte integrin expression differences between SIRS and sepsis patients.
[So] Source:Ir J Med Sci;, 2016 Oct 31.
[Is] ISSN:1863-4362
[Cp] Country of publication:Ireland
[La] Language:ENG
[Ab] Abstract:BACKGROUND: Systemic Inflammatory Response Syndrome (SIRS) and sepsis remain leading causes of death. Despite many similarities, the two entities are very distinct clinically and immunologically. T-Lymphocytes play a key pivotal role in the pathogenesis and ultimately outcome following both SIRS and sepsis. Integrins are essential in the trafficking and migration of lymphocytes. They also serve vital roles in efficient wound healing and clearance of infections. Here, we investigate whether integrin expression, specifically ß1 (CD29) and ß2 (CD18), are disrupted in SIRS and sepsis, and assess differences in integrin expression between these two critically ill clinical categories. METHODS: T-Lymphocytes were isolated from whole blood collected from ICU patients exhibiting SIRS or sepsis. Samples were analyzed for CD18 (ß2) and CD29 (ß1) on CD3(+) T cells through flow cytometry. Septic patients were stratified into either exclusively abdominal or non-abdominal sources of sepsis. RESULTS: CD18 was almost ubiquitously expressed on CD3(+) T cells irrespective of clinical condition. However, CD29 (ß1 integrin) was lowest in SIRS patients (20.4% of CD3(+) T cells) when compared with either septic patients (35.5%) or healthy volunteers (54.1%). Furthermore, there was evidence of compartmentalization in septic patients, where abdominal sources had a greater percentage of CD3(+)CD29(+) T cells (41.7%) when compared with those with non-abdominal sources (29.5%). CONCLUSION: Distinct differences in T-cell integrin expression exists between patients in SIRS versus sepsis, as well as relative to the source of sepsis. Further work is needed to understand cause and effect relative to the progression from SIRS into sepsis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161031
[Lr] Last revision date:161031
[St] Status:Publisher

  4 / 100793 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy

[PMID]: 27796617
[Au] Autor:Djoumerska-Alexieva I; Roumenina LT; Stefanova T; Vassilev T; Dimitrov JD
[Ad] Address:Department of Immunology, Stefan Angelov Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, 1113, Bulgaria. djoumer@microbio.bas.bg.
[Ti] Title:Heme-Exposed Pooled Therapeutic IgG Improves Endotoxemia Survival.
[So] Source:Inflammation;, 2016 Oct 28.
[Is] ISSN:1573-2576
[Cp] Country of publication:United States
[La] Language:ENG
[Ab] Abstract:Antibody repertoires of healthy humans and animals contain a fraction of antibodies able to acquire additional polyspecificity following exposure to several biologically relevant redox molecules (free heme, reactive oxygen species, ferrous ions, HOCl, etc.). The physiological role of these "hidden" polyspecific antibodies is poorly understood. Similar to inherently polyspecific antibodies, those with induced polyspecificicty may also have immunoregulatory properties. We have previously shown that a pooled human IgG preparation, modified by the exposure to ferrous ions, acquires the ability to significantly improve survival of animals with polymicrobial sepsis or aseptic systemic inflammation induced by bacterial lipopolysaccharide or zymosan administration. In the present study, we have analyzed the effects of administration of heme-exposed pooled human IgG in the same models of sepsis and aseptic systemic inflammation. The administration of a single dose of heme-exposed pooled IgG has resulted in a significant increase in the survival of mice with endotoxinemia, but not in those with polymicrobial sepsis and zymosan-induced severe generalized inflammation. Finally, we have provided evidence that the anti-inflammatory effect of heme-exposed IgG can be explained by scavenging of pro-inflammatory mediators.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161031
[Lr] Last revision date:161031
[St] Status:Publisher

  5 / 100793 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy

[PMID]: 27796503
[Au] Autor:Vlaovic J; Voga G
[Ad] Address:Department of Intensive Internal Medicine, General Hospital Celje, Oblakova ulica 5, 3000, Celje, Slovenia. janko.vlaovic@gmail.com.
[Ti] Title:Spontaneous pulmonary hematoma in a patient with sepsis treated with dual antiplatelet therapy.
[So] Source:Wien Klin Wochenschr;, 2016 Oct 28.
[Is] ISSN:1613-7671
[Cp] Country of publication:Austria
[La] Language:ENG
[Ab] Abstract:A 72-year-old patient was admitted to the medical intensive care unit due to a right-sided, hospital-acquired pneumonia and septic shock with respiratory failure and deterioration of chronic renal failure. During hospitalization the patient required hemodynamic support with norepinephrine and dobutamine, mechanical ventilation and hemodialysis. The patient suffered a non-ST segment elevation myocardial infarction (NSTEMI) and received dual antiplatelet therapy. After 14 days an acute intrapulmonary infiltrate of unknown origin developed, accompanied by fever and a significant increase of the C­reactive protein (CRP) level. Chest radiography and a computed tomography (CT) scan showed a well-defined, round, high-attenuation lesion in the lungs and a suspected infected pulmonary hematoma, which was confirmed by percutaneous aspiration biopsy. There was no evidence of trauma and it is believed that the hematoma occurred spontaneously, probably because of the dual antiplatelet therapy. Double antibiotic treatment was started but no surgery was performed after consultation with a thoracic surgeon. The antiplatelet drugs were temporarily withdrawn until the size of the hematoma showed no further increase and then antiplatelet therapy was continued. After stabilization the patient was discharged from hospital and 6 months later a follow-up chest X­ray showed almost complete resolution of the hematoma.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161031
[Lr] Last revision date:161031
[St] Status:Publisher

  6 / 100793 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy

[PMID]: 27796237
[Au] Autor:Manzoni P; Mostert M; Agriesti G; Priolo C; Galletto P; Farina D
[Ad] Address:a Neonatology and NICU, Sant'Anna Hospital , Torino , Italy.
[Ti] Title:Neonatal Fungal Infections: The State of the Art.
[So] Source:J Chemother;19(sup2):42-45, 2007 Oct.
[Is] ISSN:1973-9478
[Cp] Country of publication:England
[La] Language:ENG
[Ab] Abstract:Candida spp is the 3(rd) most frequent cause of sepsis in preterm infants, with high attributable mortality and poor outcome. Neonatal fungal infections include bloodstream, urine, cerebrospinal and peritoneal infections. Preterm infants display specific, often unavoidable, risk factors for SFI, with fungal colonization being the most significant one. Prompt treatment does not prevent poor long-term neurodevelopmental outcomes. Thus, prevention is the milestone, and should mainly rely on the administration of targeted prophylactic fluconazole to high-risk infants, as recently demonstrated by a large Italian multicenter study. As prevention is key in pediatrics, finally we can deliver this to this vulnerable population.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161031
[Lr] Last revision date:161031
[St] Status:In-Data-Review

  7 / 100793 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy

[PMID]: 27796233
[Au] Autor:Mussap M; Degrandi R; Cataldi L; Fanos V; Plebani M
[Ad] Address:a Laboratory Medicine , University-Hospital San Martino , Genova , Italy .
[Ti] Title:Biochemical Markers for the Early Assessment of Neonatal Sepsis: the Role of Procalcitonin.
[So] Source:J Chemother;19(sup2):35-38, 2007 Oct.
[Is] ISSN:1973-9478
[Cp] Country of publication:England
[La] Language:ENG
[Ab] Abstract:Procalcitonin (PCT) is the precursor of calcitonin, normally synthesized in the C-cells of the thyroid gland. Systemic inflammation and sepsis induce PCT production by various cell types, including hepatocytes, nephrons, monocytes. PCT begins to rise four hours after exposure to bacterial endotoxins, peaking at six to eight hours, and remaining raised for at least 24 hours with a half-life of 25-30 hours. Serum PCT levels significantly increase in systemic bacterial infection, necrotizing enterocolitis, and during both early and late onset neonatal sepsis. By using a cut-off limit of 0.5 µg/L, the PCT positive likelihood ratio was found of 12.5. PCT has a theoretical advantage as a marker of systemic bacterial infection over other cytokines because of its virtual absence in health, induction in sepsis and its half-life suitable for daily monitoring of disease progress. PCT may be useful in assessing the severity of infection, following the progress of treatment, and predicting outcomes.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161031
[Lr] Last revision date:161031
[St] Status:In-Data-Review

  8 / 100793 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy

[PMID]: 27796231
[Au] Autor:Chirico G; Cortinovis S; Fonte C; Giudici G
[Ad] Address:a Department of Neonatology and Neonatal Intensive Care , Spedali Civili , Brescia , Italy.
[Ti] Title:Bacterial Sepsis.
[So] Source:J Chemother;19(sup2):28-30, 2007 Oct.
[Is] ISSN:1973-9478
[Cp] Country of publication:England
[La] Language:ENG
[Ab] Abstract:Bacterial sepsis remain a major cause of mortality and morbidity in the newborn. The severe outcome of neonatal sepsis, despite the advances in perinatal and neonatal care and use of potent antibiotics, is related to the neonatal reduced immune defenses and the complex interactions between the infecting microorganism and the host responses. An early diagnosis, based on the clinical picture, the isolation of microorganisms and the positivity of inflammatory indexes, is mandatory. A timely treatment should be aimed to the elimination of pathogens with antimicrobials. Intravenous immunoglobulin and hematopoietic growth factors may be considered to improve the disturbed immune homeostasis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161031
[Lr] Last revision date:161031
[St] Status:In-Data-Review

  9 / 100793 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy

[PMID]: 27796230
[Au] Autor:Mussap M; Molinari MP; Senno E; Gritti P; Soro B; Mannelli S; Fabris C
[Ad] Address:a Laboratory Medicine , University-Hospital San Martino , Genova , Italy.
[Ti] Title:New Diagnostic Tools for Neonatal Sepsis: The Role of a Real-Time Polymerase Chain Reaction for the Early Detection and Identification of Bacterial and Fungal Species in Blood Samples.
[So] Source:J Chemother;19(sup2):31-34, 2007 Oct.
[Is] ISSN:1973-9478
[Cp] Country of publication:England
[La] Language:ENG
[Ab] Abstract:Early diagnosis and treatment of neonatal sepsis are essential to prevent severe and life threatening complications. Consequently, rapid diagnostic tests capable to differentiate infected from non-infected newborns have the potential to make a significant impact on neonatal care. A new real-time polymerase chain reaction (PCR; LightCycler(®) SeptiFast test M(GRADE)) has been proposed in the routine assessment of neonatal sepsis for the detection and identification of bacterial and fungal DNA from microorganisms which cause approximately 90% of all blood stream infections. The LightCycler® SeptiFast test can detect and identify simultaneously the 25 most important bacterial and fungal species causing bloodstream infections within few hours by using a small volume of a single whole blood sample. Real-time PCR can be easily incorporated into the hospital setting for term or near-term infants admitted to the neonatal intensive care unit for sepsis evaluation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161031
[Lr] Last revision date:161031
[St] Status:In-Data-Review

  10 / 100793 MEDLINE  
              first record previous record
select
to print
Photocopy

[PMID]: 27795864
[Au] Autor:Pollen M; El Jamal S; Lewin J; Manucha V
[Ad] Address:Department of Pathology, University of Mississippi Medical Center, Jackson, MS, USA.
[Ti] Title:Histiocytic Sarcoma in a Kidney Transplant Patient: A Case Report and Review of the Literature.
[So] Source:Case Rep Pathol;2016:3591050, 2016.
[Is] ISSN:2090-6781
[Cp] Country of publication:United States
[La] Language:ENG
[Ab] Abstract:Objective. Histiocytic sarcoma (HS) is an aggressive neoplasm with only limited number of reported series of cases and rare case reports of occurrence as a posttransplant neoplastic disorder. The etiology and pathogenesis of the disease is unknown and the optimal treatment is still under investigation. We describe an unusual case of HS in a patient with a remote history of kidney transplant. Method and Results. A 54-year-old male with a remote history of renal transplantation under maintenance immunosuppression presented with features of sepsis. CT abdomen revealed multiple heterogeneous masses in bilateral native kidneys and liver and enlarged abdominal and retroperitoneal lymph nodes. Viral serology work-up was negative. Needle core biopsy revealed a highly undifferentiated neoplasm comprised of highly atypical large cells with eosinophilic to vacuolated cytoplasm and hemophagocytosis. Extended panel of immunohistochemistry proved histiocytic lineage for the tumor cells. The patient expired 2 weeks following the diagnosis. Conclusion. Our case along with three previously published case reports raised the possibility of HS as a treatment-related neoplasm or a posttransplantation neoplastic disorder in solid organ transplant recipients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161031
[Lr] Last revision date:161031
[St] Status:In-Data-Review


page 1 of 10080 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information