Database : MEDLINE
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[PMID]: 25226498
[Au] Autor:Wang Y; Sun B; Yue H; Lin X; Li B; Yang X; Shan C; Fan Y; Dong M; Zhang Y; Lin W; Zuo X; Su P; Heng Y; Xu J; Kissoon N
[Ad] Address:1Departments of Pediatrics and Pediatric Critical Care, Children's Hospital of Fudan University, Shanghai, China. 2Department of Pediatrics, Huai'an Maternity and Children's Hospital, Jiangsu, China. 3Department of Pediatrics, Huai'an First People's Hospital, Huai'an, Jiangsu, China. 4Department of Pediatrics, Huai'an Second People's Hospital, Huai'an, Jiangsu, China. 5Department of Pediatrics, Huaiyin District Hospital, Huai'an, Jiangsu, China. 6Department of Pediatrics, Chuzhou District Hospital, Huai'an, Jiangsu, China. 7Department of Pediatrics, Xuyi County Hospital, Huai'an, Jiangsu, China. 8Department of Pediatrics, Xuyi County Hospital for Traditional Chinese Medicine, Huai'an, Jiangsu, China. 9Department of Pediatrics, Lianshui County Hospital, Huai'an, Jiangsu, China. 10Department of Pediatrics, Lianshui County Hospital for Traditional Chinese Medicine, Huai'an, Jiangsu, China. 11Department of Pediatrics, Jinhu County Hospital, Huai'an, Jiangsu, China. 12Department of Pediatrics, Hongze County Hospital, Huai'an, Jiangsu, China. 13Department of Pediatrics, University of British-Columbia and BC Children's Hospital, Vancouver, Canada.
[Ti] Title:An epidemiologic survey of pediatric sepsis in regional hospitals in china*.
[So] Source:Pediatr Crit Care Med;15(9):814-20, 2014 Nov.
[Is] ISSN:1529-7535
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To determine the prevalence, treatment, and outcomes of sepsis at regional hospitals in Huai'an, Jiangsu, China. DESIGN: Prospective data registry using a descriptive clinical epidemiologic approach through a collaborative network. SETTING: Pediatric departments in 11 regional city and county referral hospitals serving 843,000 children (exclusive of neonates). SUBJECTS: All admissions (n = 27,836) of patients from 28 days to 15 years old from September 1, 2010, to August 31, 2011. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: A total of 1,530 patients met the 2005 international consensus definition of sepsis, corresponding to an estimated incidence of 181/100,000 children, with 80% under 5 years old, and in 10% (153), severe sepsis or septic shock developed. The overall case fatality rate for sepsis was 3.5% (53/1,530) or 34.6% (53/153) in those in whom severe sepsis or septic shock developed. Treatment varied widely and in many instances did not conform to international guidelines as reflected by inadequate use of antibiotics, corticosteroids, vasoactive agents, and inotropes. CONCLUSIONS: We first report the prevalence and outcome of pediatric sepsis based on a regional hospital network in China. The diverse treatment approaches and practice at low-level clinics suggest the need for clinical implementation of internationally recognized strategy to improve the care standard in resource-limited regional hospitals.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1097/PCC.0000000000000247

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[PMID]: 25372699
[Au] Autor:Tanaka K; Koike Y; Shimura T; Okigami M; Ide S; Toiyama Y; Okugawa Y; Inoue Y; Araki T; Uchida K; Mohri Y; Mizoguchi A; Kusunoki M
[Ad] Address:Departments of Gastrointestinal and Paediatric Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan....
[Ti] Title:In vivo characterization of neutrophil extracellular traps in various organs of a murine sepsis model.
[So] Source:PLoS One;9(11):e111888, 2014.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Neutrophil extracellular traps (NETs) represent extracellular microbial trapping and killing. Recently, it has been implicated in thrombogenesis, autoimmune disease, and cancer progression. The aim of this study was to characterize NETs in various organs of a murine sepsis model in vivo and to investigate their associations with platelets, leukocytes, or vascular endothelium. NETs were classified as two distinct forms; cell-free NETs that were released away from neutrophils and anchored NETs that were anchored to neutrophils. Circulating cell-free NETs were characterized as fragmented or cotton-like structures, while anchored NETs were characterized as linear, reticular, membranous, or spot-like structures. In septic mice, both anchored and cell-free NETs were significantly increased in postcapillary venules of the cecum and hepatic sinusoids with increased leukocyte-endothelial interactions. NETs were also observed in both alveolar space and pulmonary capillaries of the lung. The interactions of NETs with platelet aggregates, leukocyte-platelet aggregates or vascular endothelium of arterioles and venules were observed in the microcirculation of septic mice. Microvessel occlusions which may be caused by platelet aggregates or leukocyte-platelet aggregates and heterogeneously decreased blood flow were also observed in septic mice. NETs appeared to be associated with the formation of platelet aggregates or leukocyte-platelet aggregates. These observational findings may suggest the adverse effect of intravascular NETs on the host during a sepsis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1371/journal.pone.0111888

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[PMID]: 25372085
[Au] Autor:Guillevin L; Pagnoux C; Karras A; Khouatra C; Aumaître O; Cohen P; Maurier F; Decaux O; Ninet J; Gobert P; Quémeneur T; Blanchard-Delaunay C; Godmer P; Puéchal X; Carron PL; Hatron PY; Limal N; Hamidou M; Ducret M; Daugas E; Papo T; Bonnotte B; Mahr A; Ravaud P; Mouthon L; French Vasculitis Study Group
[Ad] Address:From the Département de Médecine Interne, Hôpital Cochin, Université Paris Descartes, Sorbonne Paris Cité, INSERM Unité 1016, Centre de Référence pour les Maladies Auto-immunes Rares (L.G., C.P., P.C., X.P., A.M., L.M.), Unité de Néphrologie, Hôpital Européen Georges-Pompidou, Université Paris Descartes (A.K.), Hôpital Bichat, Université Paris Diderot, Service de Néphrologie, INSERM Unité 699, Département Hospitalo-Universitaire FIRE (E.D.) and Département de Médecine Interne (T.P.), and Centre d'Epidémiologie Clinique, Hôpital Hôtel-Dieu, Université Paris Descartes, INSERM Unité 738 (P.R.), Assistance Publique-Hôpitaux de Paris, Paris, Service de Pneumologie, Centre de Référence pour Maladies Pulmonaires Rares, Hôpital Universitaire Louis Pradel (C.K.), and Service de Médecine Interne, Hôpital Edouard Herriot (J.N.), Lyon, Centre Hospitalier Universitaire, Hôpital Gabriel Montpied, Clermont-Ferrand (O.A.), Service de Médecine Interne, Hôpitaux privés de Metz, Metz (F.M.), Département de Médecine Interne, Hôpitaux Universitaires de Rennes, Hôpital Sud, Université Rennes I, IGDR-UMR 6290, Rennes (O.D.), Service de Médecine Interne et Néphrologie, Hôpital Général Henri Duffaut, Avignon (P. Gobert), Département de Néphrologie and Département de Médecine Interne, Centre Hospitalier de Valenciennes, Valenciennes (T.Q.), Service de Médecine Interne, Centre Hospitalier Général de Niort, Niort (C.B.-D.), Département de Médecine Interne, Centre Hospitalier Bretagne Atlantique de Vannes, Vannes (P. Godmer), Service de Néphrologie, Dialyse et Transplantation, Centre Hospitalier Universitaire de Grenoble, Grenoble (P.-L.C.), Service de Médecine Interne, Centre National de Référence de la Sclérodermie Systémique, Hôpital Claude Huriez, Université Lille Nord de France, Centre Hospitalier Universitaire de Lille, Lille (P.-Y.H.), Service de Médecine Interne, Centre de Référence Labellisé pour la Prise en Charge des C
[Ti] Title:Rituximab versus azathioprine for maintenance in ANCA-associated vasculitis.
[So] Source:N Engl J Med;371(19):1771-80, 2014 Nov 6.
[Is] ISSN:1533-4406
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: The combination of cyclophosphamide and glucocorticoids leads to remission in most patients with antineutrophil cytoplasm antibody (ANCA)-associated vasculitides. However, even when patients receive maintenance treatment with azathioprine or methotrexate, the relapse rate remains high. Rituximab may help to maintain remission. METHODS: Patients with newly diagnosed or relapsing granulomatosis with polyangiitis, microscopic polyangiitis, or renal-limited ANCA-associated vasculitis in complete remission after a cyclophosphamide-glucocorticoid regimen were randomly assigned to receive either 500 mg of rituximab on days 0 and 14 and at months 6, 12, and 18 after study entry or daily azathioprine until month 22. The primary end point at month 28 was the rate of major relapse (the reappearance of disease activity or worsening, with a Birmingham Vasculitis Activity Score >0, and involvement of one or more major organs, disease-related life-threatening events, or both). RESULTS: The 115 enrolled patients (87 with granulomatosis with polyangiitis, 23 with microscopic polyangiitis, and 5 with renal-limited ANCA-associated vasculitis) received azathioprine (58 patients) or rituximab (57 patients). At month 28, major relapse had occurred in 17 patients in the azathioprine group (29%) and in 3 patients in the rituximab group (5%) (hazard ratio for relapse, 6.61; 95% confidence interval, 1.56 to 27.96; P=0.002). The frequencies of severe adverse events were similar in the two groups. Twenty-five patients in each group (P=0.92) had severe adverse events; there were 44 events in the azathioprine group and 45 in the rituximab group. Eight patients in the azathioprine group and 11 in the rituximab group had severe infections, and cancer developed in 2 patients in the azathioprine group and 1 in the rituximab group. Two patients in the azathioprine group died (1 from sepsis and 1 from pancreatic cancer). CONCLUSIONS: More patients with ANCA-associated vasculitides had sustained remission at month 28 with rituximab than with azathioprine. (Funded by the French Ministry of Health; MAINRITSAN ClinicalTrials.gov number, NCT00748644; EudraCT number, 2008-002846-51.).
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1411
[Js] Journal subset:AIM; IM
[Cl] Clinical Trial:ClinicalTrial
[St] Status:In-Process
[do] DOI:10.1056/NEJMoa1404231

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[PMID]: 24871076
[Au] Autor:Patra S; Bhat Y R; Lewis LE; Purakayastha J; Sivaramaraju VV; Kalwaje E V; Mishra S
[Ad] Address:Department of Pediatrics, Kasturba Medical College, Manipal University, Manipal, 576104, Udupi District, Karnataka, India, dr.saikatpatra@gmail.com.
[Ti] Title:Burkholderia cepacia Sepsis Among Neonates.
[So] Source:Indian J Pediatr;81(11):1233-6, 2014 Nov.
[Is] ISSN:0973-7693
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:Burkholderia cepacia is a rare cause of sepsis in newborns and its transmission involves human contact with heavily contaminated medical devices and disinfectants. The authors aimed to determine epidemiology, clinical features, antibiotic sensitivity pattern, complications and outcome of blood culture proven B. cepacia infections in 12 neonates. All neonates were outborn, 5 preterm and 7 term. B. cepacia was isolated from blood in all and concurrently from CSF in three neonates. Lethargy and respiratory distress (41.7 %) were major presenting features. Five newborns (41.7 %) required mechanical ventilation for 3-7 d. Highest bacterial susceptibility was observed for meropenem (100 %), followed by cefoperazone-sulbactam, piperacillin-tazobactam, sulfamethoxazole-trimethoprim (all 83 %), ceftazidime (75 %) and ciprofloxacin (42 %). Piperacillin-tazobactam, ciprofloxacin and cotrimoxazole either singly or in combination led to complete recovery of 11 (91.7 %) newborns; one developed hydrocephalus. Eight of nine infants who completed 6 mo follow up were normal. Prompt recognition and appropriate antibiotic therapy for B. cepacia infection results in complete recovery in majority.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s12098-014-1473-9

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[PMID]: 24936547
[Au] Autor:Almoosa KF; Gupta A; Pedroza C; Watts NB
[Ad] Address:University of Texas Health Science Center, Houston, Texas....
[Ti] Title:Low Testosterone Levels are Frequent in Patients with Acute Respiratory Failure and are Associated with Poor Outcomes.
[So] Source:Endocr Pract;20(10):1057-63, 2014 Oct 1.
[Is] ISSN:1934-2403
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Low testosterone level is a common finding in critically ill patients with trauma, shock, and sepsis. However, its prevalence and outcomes in patients with primary acute respiratory failure is unknown; low testosterone could contribute to respiratory muscle weakness and further compromise ventilation in these patients. METHODS: We aimed to determine the prevalence, severity, and effects of hypotestosteronemia in patients with acute respiratory failure in a 16-bed single academic center medical intensive care unit (ICU). We studied 30 men who required mechanical ventilation for ≥24 hours for a primary diagnosis of acute respiratory failure. Blood samples were drawn on ICU day 1 and day 3 to measure serum levels of total and free testosterone. RESULTS: Hypotestosteronemia (level below the lower reference limit) was present on day 1 in 93.1% (total testosterone) and 76.7% (free testosterone) of patients and on day 3 in 94.4% (total testosterone) and 100% (free testosterone) of patients. Sex hormone-binding globulin, dehydroepiandrosterone sulfate, follicle-stimulating hormone, luteinizing hormone, and thyroid function levels were all within stated reference ranges. Total and free testosterone levels correlated inversely with ventilator days and ICU length of stay. CONCLUSION: Hypotestosteronemia is common in mechanically ventilated patients with primary acute respiratory failure and may contribute to longer ICU stay. Further studies are needed to determine the effect of testosterone replacement on short- and long-term outcomes in these patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.4158/EP14003.OR

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[PMID]: 24936545
[Au] Autor:Dendy JA; Chockalingam V; Tirumalasetty NN; Dornelles A; Blonde L; Bolton PM; Meadows RY; Andrews SS
[Ad] Address:Department of Internal Medicine, Ochsner Medical Center, New Orleans, Louisiana....
[Ti] Title:Identifying risk factors for severe hypoglycemia in hospitalized patients with diabetes.
[So] Source:Endocr Pract;20(10):1051-6, 2014 Oct 1.
[Is] ISSN:1934-2403
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Some of the deleterious effects of hypoglycemia in hospitalized patients include increased rates of mortality and longer length of stay. Our primary objective was to identify the risk factors associated with severe hypoglycemia to identify those patients at highest risk. METHODS: The medical records of 5,026 patients with diabetes mellitus (DM) admitted in 2010 were reviewed to identify those patients that developed severe hypoglycemia (blood glucose [BG] <40 mg/dL). We performed χ2 tests to assess statistical significance. Adjusted logical regression was used to determine the risk factors for hypoglycemia in the hospital. RESULTS: Out of 5,026 DM patients included in our review, 81 experienced severe hypoglycemia (1.6%). Statistically higher proportions of chronic kidney disease (CKD; 69.1% vs. 46.9%, P<.001), congestive heart failure (CHF; 48.1% vs. 28.5%, P<.001), sepsis (49.4% vs. 12.5%, P<.001), insulin use (45.7% vs. 26.04%, P = .000), type 1 DM (21% vs. 5.1%, P = .000), and cirrhosis (14.8% vs. 7.2%, P = .009) were seen in the severe hypoglycemic group compared to the nonsevere hypoglycemic group. Overall, 84% of patients who experienced an episode of severe hypoglycemia in the hospital (BG <40 mg/dL) had a previous episode of hypoglycemia (BG <70 mg/dL). The odds ratios (ORs) for type 1 DM, sepsis, previous hypoglycemia, and insulin use were 3.43 (95% confidence interval [CI] 1.81, 6.49), 2.64 (95% CI 1.6, 4.35), 46.1 (95% CI 24.76, 85.74), and 1.66 (95% CI 1.02, 2.69), respectively. CONCLUSION: Prior episodes of hypoglycemia in the hospital, the presence of type 1 DM, insulin use, and sepsis were identified as independent risk factors for the development of severe hypoglycemia in the hospital.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.4158/EP13467.OR

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[PMID]: 25374713
[Au] Autor:Yu HH; Tsang S; Cheung TT; Lo CM
[Ad] Address:Department of Surgery, The University of Hong Kong, 102 Pokfulam Road, Hong Kong....
[Ti] Title:Surviving emphysematous gastritis after hepatectomy.
[So] Source:Case Reports Hepatol;2013:106383, 2013.
[Is] ISSN:2090-6587
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Emphysematous gastritis is a rare variant of phlegmonous gastritis due to invasion of stomach wall by gas-forming bacteria. It is characterised by abnormal presence of gas in the stomach by imaging, in association with clinical sepsis. Patients suffering from this condition usually present with an underlying pathology. We are reporting a middle-aged Chinese male with hepatitis B virus related hepatocellular carcinoma. He underwent partial hepatectomy and was diagnosed with emphysematous gastritis 4 days after index operation. Emergency laparotomy, including upper endoscopy, was performed. He was managed with antibiotics and discharged 18 days after second operation. This paper shows a review of the literature about the disease, with particular attention to pathology, clinical features, and management.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Da] Date of entry for processing:141106
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1155/2013/106383

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[PMID]: 25374020
[Au] Autor:Chen L; Cao D; Li LX; Zhao Y; Xie CM; Zhang YH
[Ad] Address:Minhang District Center for Disease Control and Prevention, Shanghai 201101, China....
[Ti] Title:Assessment of Exposure to Polybrominated Dipheny Ethers via Inhalation and Diet in China.
[So] Source:Biomed Environ Sci;27(11):872-82, 2014 Nov.
[Is] ISSN:0895-3988
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: This paper is to assess the current status of polybrominated diphenyl ethers (PBDEs) contamination in the environment in China and estimate the exposure to PBDEs in non-occupational populations. METHODS: A total of 80 research papers published from January 2001 to October 2013 were selected. Geographic information system (GIS) was used in mapping PBDE concentrations and distributions in environmental media. Ni's model was applied to calculate ∑PBDE-intake via the intakes of contaminated food, water and air in the Pearl River Delta and Yangtze River Delta. RESULTS: BDE-209 was found to be the major PBDE congener in the environmental media and food in China. PBDE concentrations varied among different areas, among which the contamination in Guangdong Province was most serious. Daily intake of ∑PBDEs was 225.1-446.0 ng/d for adults in the Pearl River Delta, which was higher than the intake for those living in the Yangtze River Delta (148.9-369.8 ng/d). CONCLUSION: Atorvastatin can attenuate LPS-induced TNF-α expression and production by activating HO-1 via the ERK and p38 MAPK pathways, suggesting that atorvastatin can be used in treatment of inflammatory diseases such as sepsis, especially in those with atherosclerotic diseases.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.3967/bes2014.124

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[PMID]: 25367365
[Au] Autor:Chigaev A; Smagley Y; Sklar LA
[Ad] Address:Department of Pathology and University of New Mexico Cancer Center, Albuquerque 87131, NM, USA. achigaev@salud.unm.edu.
[Ti] Title:Carbon monoxide down-regulates α4ß1 integrin-specific ligand binding and cell adhesion: a possible mechanism for cell mobilization.
[So] Source:BMC Immunol;15(1):52, 2014.
[Is] ISSN:1471-2172
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Carbon monoxide (CO), a byproduct of heme degradation, is attracting growing attention from the scientific community. At physiological concentrations, CO plays a role as a signal messenger that regulates a number of physiological processes. CO releasing molecules are under evaluation in preclinical models for the management of inflammation, sepsis, ischemia/reperfusion injury, and organ transplantation. Because of our discovery that nitric oxide signaling actively down-regulates integrin affinity and cell adhesion, and the similarity between nitric oxide and CO-dependent signaling, we studied the effects of CO on integrin signaling and cell adhesion. RESULTS: We used a cell permeable CO releasing molecule (CORM-2) to elevate intracellular CO, and a fluorescent Very Late Antigen-4 (VLA-4, α4ß1-integrin)-specific ligand to evaluate the integrin state in real-time on live cells. We show that the binding of the ligand can be rapidly down-modulated in resting cells and after inside-out activation through several Gαi-coupled receptors. Moreover, cell treatment with hemin, a natural source of CO, resulted in comparable VLA-4 ligand dissociation. Inhibition of VLA-4 ligand binding by CO had a dramatic effect on cell-cell interaction in a VLA-4/VCAM-1-dependent cell adhesion system. CONCLUSIONS: We conclude that the CO signaling pathway can rapidly down-modulate binding of the VLA-4 -specific ligand. We propose that CO-regulated integrin deactivation provides a basis for modulation of immune cell adhesion as well as rapid cell mobilization, for example as shown for splenic monocytes in response to surgically induced ischemia of the myocardium.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1186/s12865-014-0052-1

  10 / 88626 MEDLINE  
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[PMID]: 25361609
[Au] Autor:Trajano AD; Pereira BM; Fraga GP
[Ad] Address:Division of Trauma Surgery, Department of Surgery, School of Medical Sciences, University of Campinas, Campinas, SP, Brazil. adrianotrajano@gmail.com.
[Ti] Title:Epidemiology of in-hospital trauma deaths in a Brazilian university hospital.
[So] Source:BMC Emerg Med;14(1):22, 2014.
[Is] ISSN:1471-227X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: The analysis of patterns of trauma deaths may improve the evaluation of a trauma system and identify areas that may benefit from more resources. The objective of this study was to analyze the epidemiology of trauma deaths in a Brazilian university hospital in order to assess the profile of these fatalities over a 16-year period. METHOD: Retrospective study of time series using database records. The research subjects were in-hospital deaths from external causes during the years 1995, 2000, 2005 and 2010. The following variables were analyzed: cause of injury, trauma scores, time and cause of death. RESULTS: 467 cases were studied, being 325 patients (69.6%) admitted with signs of life and 142 (30.4%) considered dead on arrival. The mean age was 35.35 ± 18.03 years. 85.4% were males. Blunt trauma occurred in 73.0% of cases and penetrating mechanism in 27.0%. There was a significant increase (p < 0.001) in deaths from motorcycle crashes over the years, which went from 7.3% in 1995 to 31.5% in 2010. In contrast, there was a significant decrease (p = 0.030) in firearm-injury victims; from 21.0% in 1995 to 9.6% in 2010. About 60% of deaths occurred less than 24 hours after admission. The main causes of death were lesions of the central nervous system (56.3% of the total), followed by hemorrhagic shock (18.1%) and sepsis/multiple organ dysfunction syndrome (17.1%). The mean Injury Severity Score (ISS) of patients with signs of life was 26.41 ± 9.00, 71.3% of whom had ISS >25. The mean Revised Trauma Score (RTS) was 5.24 ± 2.05. Only 25.8% of the deaths had TRISS <0.50. CONCLUSION: There was a shift in the profile of causes of death from trauma in this university teaching hospital, with a large decrease in penetrating injuries and a higher incidence of deaths of motorcycle riders.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1186/1471-227X-14-22


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