Database : MEDLINE
Search on : Sepsis [Words]
References found : 86846 [refine]
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[PMID]: 25024272
[Au] Autor:Dondorp AM; Haniffa R
[Ad] Address:Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford, UK Arjen@tropmedres.ac.
[Ti] Title:Critical care and severe sepsis in resource poor settings.
[So] Source:Trans R Soc Trop Med Hyg;108(8):453-4, 2014 Aug.
[Is] ISSN:1878-3503
[Cp] Country of publication:England
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1093/trstmh/tru099

  2 / 86846 MEDLINE  
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[PMID]: 24768917
[Au] Autor:Wang HE; Baddley J; Griffin RL; Judd S; Howard G; Donnelly JP; Safford MM
[Ad] Address:Department of Emergency Medicine, University of Alabama School of Medicine, USA. Electronic address: hwang@uabmc.edu....
[Ti] Title:Physical inactivity and long-term rates of community-acquired sepsis.
[So] Source:Prev Med;65:58-64, 2014 Aug.
[Is] ISSN:1096-0260
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: The authors sought to determine the association between physical inactivity (characterized by exercise and television watching levels) and long-term rates of community-acquired sepsis. METHODS: The study utilized a population-based cohort of 30,183 adult (≥45 years) community dwelling adults. Subjects reported weekly exercise (low=none, medium=1-3times/week, high=≥4times/week) and daily television watching (low=<1h/day, medium=1-3h/day, high=≥4h/day) levels. The authors evaluated the association between exercise, television watching and rates of sepsis, defined as hospital treatment for a serious infection with ≥2 Systemic Inflammatory Response Syndrome (SIRS) criteria. RESULTS: Among 30,183 participants, 1500 experienced a sepsis event. Reported weekly exercise was: high 8798 (29.2%), medium 10,695 (35.4%), and low 10,240 (33.9%). Where available, reported daily television watching was: low 4615 (19.6%), medium 11,587 (49.3%) and high 7317 (31.1%). Decreased weekly exercise was associated with increased adjusted sepsis rates (high - referent; medium - HR 1.02, 95% CI 0.96-1.20; low - 1.33, 1.13-1.56). Daily television watching was not associated with sepsis rates. Sepsis rates were highest among those with both low exercise and high television watching levels (HR 1.49, 95% CI: 1.10-2.01). CONCLUSIONS: Physical inactivity may be associated with increased long-term rates of community-acquired sepsis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review

  3 / 86846 MEDLINE  
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[PMID]: 25019241
[Au] Autor:Yang L; Xie M; Yang M; Yu Y; Zhu S; Hou W; Kang R; Lotze MT; Billiar TR; Wang H; Cao L; Tang D
[Ad] Address:Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China....
[Ti] Title:PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis.
[So] Source:Nat Commun;5:4436, 2014.
[Is] ISSN:2041-1723
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Increasing evidence suggests the important role of metabolic reprogramming in the regulation of the innate inflammatory response, but the underlying mechanism remains unclear. Here we provide evidence to support a novel role for the pyruvate kinase M2 (PKM2)-mediated Warburg effect, namely aerobic glycolysis, in the regulation of high-mobility group box 1 (HMGB1) release. PKM2 interacts with hypoxia-inducible factor 1α (HIF1α) and activates the HIF-1α-dependent transcription of enzymes necessary for aerobic glycolysis in macrophages. Knockdown of PKM2, HIF1α and glycolysis-related genes uniformly decreases lactate production and HMGB1 release. Similarly, a potential PKM2 inhibitor, shikonin, reduces serum lactate and HMGB1 levels, and protects mice from lethal endotoxemia and sepsis. Collectively, these findings shed light on a novel mechanism for metabolic control of inflammation by regulating HMGB1 release and highlight the importance of targeting aerobic glycolysis in the treatment of sepsis and other inflammatory diseases.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1038/ncomms5436

  4 / 86846 MEDLINE  
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[PMID]: 24855912
[Au] Autor:Takazono T; Nakamura S; Imamura Y; Yoshioka S; Miyazaki T; Izumikawa K; Sawai T; Matsuo N; Yanagihara K; Suyama N; Kohno S
[Ad] Address:Department of Internal Medicine, Nagasaki Municipal Hospital, Nagasaki, Japan; Department of Respiratory Diseases, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. Electronic address: takahiro-takazono@nagasaki-u.ac.jp....
[Ti] Title:A retrospective comparative study of recombinant human thrombomodulin and gabexate mesilate in sepsis-induced disseminated intravascular coagulation patients.
[So] Source:J Infect Chemother;20(8):484-8, 2014 Aug.
[Is] ISSN:1437-7780
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:The novel biological agent recombinant human thrombomodulin (rhTM) has been used clinically in Japan to treat disseminated intravascular coagulation (DIC) since 2008. Previous studies have shown the efficacy of rhTM versus heparin therapy or non-rhTM therapy. We retrospectively evaluated and compared the efficacies of rhTM and gabexate mesilate (GM) in patients diagnosed with sepsis-induced DIC. From September 2010 to October 2012, patients with sepsis-induced DIC who were treated with rhTM (n=13) or GM (n=10) at Nagasaki Municipal Hospital were extracted. Patients receiving other anticoagulants in combination were excluded. Clinical information, laboratory data, Sequential Organ Failure Assessment (SOFA) scores, and DIC scores were obtained from the medical records. Mortality at days 7 and 30 after DIC diagnosis and changes in laboratory data and SOFA scores from days 1-7 were evaluated. The groups' clinical characteristics did not differ, except for the relatively higher C-reactive protein (CRP) levels in the rhTM group (P=0.0508). The survival rates of the rhTM and GM groups on days 7 and 30 were 92.3%, 69.2% and 80%, 70%, respectively, both group indicated similar mortality. However, on day 7, the platelet counts, SOFA scores, and CRP levels significantly improved in the rhTM group; the platelet counts and SOFA scores did not improve significantly in the GM group. The platelet counts of the rhTM group significantly improved compared to the GM group (P=0.004). Recombinant human thrombomodulin might be more effective for sepsis-induced DIC than GM.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review

  5 / 86846 MEDLINE  
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[PMID]: 25024976
[Au] Autor:Momtaz HE; Sabzehei MK; Rasuli B; Torabian S
[Ad] Address:Department of Pediatrics, Hamadan University of Medical Sciences, Hamedan, IR Iran....
[Ti] Title:The main etiologies of acute kidney injury in the newborns hospitalized in the neonatal intensive care unit.
[So] Source:J Clin Neonatol;3(2):99-102, 2014 Apr.
[Is] ISSN:2249-4847
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Acute kidney injury (AKI) is one of the most common diseases among the newborns hospitalized in the neonatal intensive care units (NICUs), which is usually resulted from predisposing factors including sepsis, hypovolemia, asphyxia, respiratory distress syndrome (RDS), and heart failure. The goal of this study was to assess main etiologies, relevant risk factors, and early outcome of neonatal AKI. MATERIALS AND METHODS: In a cross- sectional study, 49 consecutive neonates hospitalized in NICU of Besat hospital with diagnosis of AKI from October 2009 to October 2011 were investigated through census sampling method. AKI was diagnosed based on urine output and serum creatinine levels. RESULTS: The prevalence of AKI was 1.54% (49 out of 3166 newborns hospitalized in NICU) with the female: male was 7:1. Thirty-nine patients (79.5%) were full-term neonates. Oliguria was observed in 38 (77.5%) patients. Sepsis was the most common predisposing factor for AKI in 77.5% of patients (n = 38) accompanied with the highest mortality rate among other factors (30.5%). Other leading causes of AKI included hypovolemia secondary to dehydration, followed by hypoxia secondary to RDS, patent ductus arteriosus, posterior urethral valve, asphyxia, and renal venous thrombosis. A positive relationship was observed between neonates' age, sex, urine output, and also between serum creatinine levels with initiation of dialysis. The mortality rate among the newborns hospitalized with AKI was 36.7%. Eighteen (36.7%) newborns were treated with peritoneal dialysis (PD) of whom 10 patients (55.6%) died, 31 patients were managed conservatively of whom five neonate died (25.9%). DISCUSSION: Prognosis of AKI in the oliguric neonates requiring PD is very poor. It is thus recommended to prevent AKI by predicting and rapid diagnosis of AKI in patients with potential risk factors and also by early and effective treatment of such factors in individuals with AKI.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Da] Date of entry for processing:140715
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.4103/2249-4847.134691

  6 / 86846 MEDLINE  
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[PMID]: 24840167
[Au] Autor:Chang R; Wang Y; Chang J; Wen L; Jiang Z; Yang T; Yu K
[Ad] Address:Department of Emergency Medicine, Institute of Cardiopulmonary Cerebral Resuscitation, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, 510120, China, rubby866@126.com.
[Ti] Title:LPS preconditioning ameliorates intestinal injury in a rat model of hemorrhagic shock.
[So] Source:Inflamm Res;63(8):675-82, 2014 Aug.
[Is] ISSN:1420-908X
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:OBJECTIVE AND DESIGN: Previous studies indicate that endotoxin preconditioning may decrease the inflammatory response and alleviate intestinal mucosal damage caused by sepsis. However, it is not known whether preconditioning with endotoxin might protect the intestinal mucosa after hemorrhagic shock. In this study, we investigated the effect of lipopolysaccharide (LPS) preconditioning on the intestinal mucosa following hemorrhagic shock in a rat model. Given that intestinal toll-like receptor 4 (TLR4) signaling is exaggerated in response to LPS, we further investigated the role of TLR4 signaling in endotoxin tolerance. METHODS: Animals were pre-treated with intra-peritoneal Escherichia coli LPS for 5days prior to hemorrhagic shock. Animals were bled to achieve a mean arterial pressure (MAP) of 35-40mmHg, then resuscitated with Ringer solution and the heparinized shed blood to maintain MAP between 90 and 100mmHg. The distal ileum was harvested after resuscitation and graded for mucosal damage. TNF-α, TLR4, cleaved caspase-3, and intestinal trefoil factor 3 (TFF3) levels were measured at different time points. RESULTS: Pretreatment with LPS significantly reduced intestinal mucosal damage and protein levels of cleaved caspase-3. Furthermore, animals pre-treated with LPS experienced reduction of TNF-α and increased mucosal expression of TFF3. LPS tolerance was associated with reduced TLR4 expression. CONCLUSIONS: Endotoxin preconditioning can lessen the effects of ischemia and reperfusion injury in intestinal mucosa of a rat model with hemorrhagic shock. It is hypothesized that this effect is mediated via inhibition of TLR4 over-expression.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s00011-014-0740-6

  7 / 86846 MEDLINE  
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[PMID]: 24802890
[Au] Autor:Mihaylova S; Schweighfer H; Hackstein H; Rosengarten B
[Ad] Address:Departments of Neurology, Justus-Liebig University Giessen, Klinikstrasse 33, 35392, Giessen, Germany.
[Ti] Title:Effects of anti-inflammatory vagus nerve stimulation in endotoxemic rats on blood and spleen lymphocyte subsets.
[So] Source:Inflamm Res;63(8):683-90, 2014 Aug.
[Is] ISSN:1420-908X
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:BACKGROUND: Anti-inflammatory cytokine effects of vagus nerve stimulation in sepsis syndromes are well established. Effects on immune cells are less clear. Therefore, we studied changes in peripheral and spleen leukocyte subsets in an endotoxic rat sepsis model. METHODS: Ventilated and sedated adult male SD rats received 5mg/kg b.w. lipopolysaccharide intravenously to induce endotoxic sepsis. Controls and a group with both-sided vagotomy were compared to animals with both sided vagotomy and left distal vagus nerve stimulation. 4.5h after sepsis induction immune cell counts and types in the peripheral blood and spleen were determined [T-lymphocytes (CD3+), T-helper cells (CD3+ CD4+), activated T-helper cells (CD3+ CD4+ CD134+), cytotoxic T-cells (CD3+ CD8+), activated cytotoxic T-cells (CD3+ CD8+ CD134+), B-lymphocytes (CD45R+ CD11cneg-dim), dendritic cells (CD11c+ OX-62+), natural killer cells (CD161+ CD3neg) and granulocytes (His48+)] together with cytokine and chemokine plasma levels (IL10; IFN-g, TNF-a, Cxcl5, Ccl5). RESULTS: Blood cell counts declined in all LPS groups. However, vagus nerve stimulation but not vagotomy activated cytotoxic T-cells. Vagotomy also depleted natural killer cells. In the spleen, vagotomy resulted in a strong decline of all cell types which was not present in the other septic groups where only granulocyte numbers declined. CONCLUSION: Vagotomy strongly declines immune cell counts in the septic spleen. This could not be explained by an evasion or apoptosis of cells. A marginalisation of spleen immune cells into the peripheral microcirculation might be therefore most likely. Further studies are warranted to clear this issue.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s00011-014-0741-5

  8 / 86846 MEDLINE  
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[PMID]: 25024871
[Au] Autor:Kim HW; Yoon JH; Jin SJ; Kim SB; Ku NS; Jeong SJ; Han SH; Choi JY; Kim JM; Song YG
[Ad] Address:Department of Internal Medicine and AIDS Research Institutes, Yonsei University College of Medicine, Seoul, Korea....
[Ti] Title:Delta neutrophil index as a prognostic marker of early mortality in gram negative bacteremia.
[So] Source:Infect Chemother;46(2):94-102, 2014 Jun.
[Is] ISSN:2093-2340
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:BACKGROUND: Sepsis is a syndrome that results in high morbidity and mortality. We investigated the delta neutrophil index (DN) as a predictive marker of early mortality in patients with gram-negative bacteremia. MATERIALS AND METHODS: We conducted a retrospective study at a tertiary referral hospital in South Korea from November 2010 to March 2011. The DN was measured at onset of bacteremia and 24 hours and 72 hours later. The DN was calculated using an automatic hematology analyzer. Factors associated with 10-day mortality were assessed using logistic regression. RESULTS: A total of 172 patients with gram-negative bacteremia were included in the analysis; of these, 17 patients died within 10 days of bacteremia onset. In multivariate analysis, Sequental organ failure assessment scores (odds ratio [OR]: 2.24, 95% confidence interval [CI]: 1.31 to 3.84; P = 0.003), DN-day 1 ≥ 7.6% (OR: 305.18, 95% CI: 1.73 to 53983.52; P = 0.030) and DN-day 3 ≥ DN-day 1 (OR: 77.77, 95% CI: 1.90 to 3188.05; P = 0.022) were independent factors associated with early mortality in gram-negative bacteremia. Of four multivariate models developed and tested using various factors, the model using both DN-day 1 ≥ 7.6% and DN-day 3 ≥ DN-day 1 was most predictive early mortality. CONCLUSIONS: DN may be a useful marker of early mortality in patients with gram-negative bacteremia. We found both DN-day 1 and DN trend to be significantly associated with early mortality.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Da] Date of entry for processing:140715
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.3947/ic.2014.46.2.94

  9 / 86846 MEDLINE  
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[PMID]: 25023084
[Au] Autor:Kondani DA; Gini-Ehungu JL; Bodi JM; Ekulu PM; Kunuanunua TS; Aloni MN
[Ad] Address:Haemato-Oncology and Nephrology Division, Haematology Unit, Department of Paediatrics, University Hospital of Kinshasa, School of Medicine, University of Kinshasa , Kinshasa , Democratic Republic of Congo.
[Ti] Title:Prevalence of sickle cell disease in a pediatric population suffering from severe infections: a congolese experience.
[So] Source:Hemoglobin;38(4):225-9, 2014.
[Is] ISSN:1532-432X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Abstract Neonatal screening for sickle cell anemia is not a common practice in the Democratic Republic of Congo (DRC). Children with sickle cell disease are known to have an increased risk of infections. We conducted a pilot study to determine the prevalence of sickle cell anemia during episodes of severe infection. A prospective study was conducted from July 2009 to July 2011. The study sites included four public hospitals at Kinshasa, DRC. The study population was selected from the source population using three-stage sampling. A total of 247 children with severe infection were consecutively recruited and screened for sickle cell disease. There were 124 boys (50.2%) and 123 girls (49.8%) with a sex-ratio of 1:1. More than two-thirds of patients (66.0%) were children between 1 and 24 months of age. Among these 247 children, 19 (7.7%) were homozygous sickle cell anemia patients (Hb SS). No patient had received Hemophilus influenzae, streptococcus pneumoniae and salmonella sp vaccines. Sepsis was the most common form of severe infection observed in 44.5% of patients. A total of 19 (7.7%) positive blood cultures were recorded. Most cases were reported in sickle cell patients (15.8%) compared to 6.1% in children who were negative for Hb S [6(A3)Glu→Val; HBB: c.20A>T] (p > 0.05). Of 247 children with severe infection, approximately 8.0% carried unknown sickle cell anemia mutations. Based on the findings in this study, opportunistic testing for sickle cell anemia is possible and worthwhile in children who present with severe infection in DRC until neonatal screening is universal.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.3109/03630269.2014.917658

  10 / 86846 MEDLINE  
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[PMID]: 25024994
[Au] Autor:Greco R; Mancini N; Peccatori J; Cieri N; Vago L; Giglio F; Morelli M; Ghidoli N; Carletti S; Levati G; Crucitti L; Sala E; Lupo Stanghellini MT; Lorentino F; Forcina A; Pavesi F; Carrabba M; Marktel S; Assanelli A; Marcatti M; Bernardi M; Corti C; Doglioni C; Scarpellini P; Burioni R; Bonini C; Clementi M; Ciceri F
[Ad] Address:Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy....
[Ti] Title:Early molecular diagnosis of aspergillosis in a patient with acute myeloid leukaemia.
[So] Source:Heart Lung Vessel;6(2):119-24, 2014.
[Is] ISSN:2282-8419
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:Diagnosis of invasive fungal infection remains challenging. Here we report a case of early diagnosis of invasive aspergillosis in a neutropenic patient affected by acute myeloid leukaemia, achieved through the detection of Aspergillus fumigatus species-specific ribonucleic acid sequences by a sensitive multiplex real-time polymerase chain reaction-based molecular assay. Thanks to the early diagnosis, targeted therapy was promptly established and the severe fungal infection controlled, allowing the patient to subsequently receive allogeneic hematopoietic stem cell transplantation from a haploidentical donor, her only curative option. Also in this instance, targeted secondary antifungal prophylaxis with voriconazole avoided any other fungal infection afterwards. This report suggests how the implementation of molecular assays in combination with routine diagnostic procedures, can improve microbiological diagnosis in sepsis, particularly in case of fungal infection, difficult to detect with standard microbiological culture methods.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Da] Date of entry for processing:140715
[St] Status:PubMed-not-MEDLINE


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