Database : MEDLINE
Search on : Serum and Globulins [Words]
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[PMID]: 29267496
[Au] Autor:Wu L; Wang X; Chen F; Lv X; Sun W; Guo Y; Hou H; Ji H; Wei W; Gong L
[Ad] Address:Department of Ultrasonography, Tianjin Medical University General Hospital, Tianjin, China.
[Ti] Title:T cell subsets and immunoglobulin G levels are associated with the infection status of systemic lupus erythematosus patients.
[So] Source:Braz J Med Biol Res;51(2):e4547, 2017 Dec 11.
[Is] ISSN:1414-431X
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:Systemic lupus erythematosus (SLE) is a chronic, autoimmune disorder that affects nearly all organs and tissues. As knowledge about the mechanism of SLE has increased, some immunosuppressive agents have become routinely used in clinical care, and infections have become one of the direct causes of mortality in SLE patients. To identify the risk factors indicative of infection in SLE patients, a case control study of our hospital's medical records between 2011 and 2013 was performed. We reviewed the records of 117 SLE patients with infection and 61 SLE patients without infection. Changes in the levels of T cell subsets, immunoglobulin G (IgG), complement C3, complement C4, globulin, and anti-double-stranded DNA (anti-ds-DNA) were detected. CD4+ and CD4+/CD8+ T cell levels were significantly lower and CD8+ T cell levels were significantly greater in SLE patients with infection than in SLE patients without infection. Additionally, the concentrations of IgG in SLE patients with infection were significantly lower than those in SLE patients without infection. However, complement C3, complement C4, globulin, and anti-ds-DNA levels were not significantly different in SLE patients with and without infection. Therefore, clinical testing for T cell subsets and IgG is potentially useful for identifying the presence of infection in SLE patients and for distinguishing a lupus flare from an acute infection.
[Mh] MeSH terms primary: Immunoglobulin G/blood
Infection/blood
Infection/pathology
Lupus Erythematosus, Systemic/blood
Lupus Erythematosus, Systemic/pathology
T-Lymphocyte Subsets/pathology
[Mh] MeSH terms secundary: Adolescent
Adult
Aged
Antibodies, Antinuclear/blood
Complement C3/analysis
Complement C4/analysis
Enzyme-Linked Immunosorbent Assay
Female
Flow Cytometry
Humans
Infection/immunology
Lupus Erythematosus, Systemic/immunology
Male
Middle Aged
Nephelometry and Turbidimetry
Polymerase Chain Reaction
Risk Factors
Serum Globulins/analysis
Statistics, Nonparametric
T-Lymphocyte Subsets/immunology
Young Adult
[Pt] Publication type:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Name of substance:0 (Antibodies, Antinuclear); 0 (Complement C3); 0 (Complement C4); 0 (Immunoglobulin G); 0 (Serum Globulins)
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:171222
[St] Status:MEDLINE

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[PMID]: 29507120
[Au] Autor:João C; Negi VS; Kazatchkine MD; Bayry J; Kaveri SV
[Ad] Address:Hematology Department, Champalimaud Center for the Unknown, Lisbon 1400-038, Portugal.
[Ti] Title:Passive Serum Therapy to Immunomodulation by IVIG: A Fascinating Journey of Antibodies.
[So] Source:J Immunol;200(6):1957-1963, 2018 Mar 15.
[Is] ISSN:1550-6606
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The immunoregulatory and anti-infective properties of normal circulating polyclonal Abs have been exploited for the therapeutic purposes in the form of IVIG as well as several hyperimmune globulins. Current knowledge on the therapeutic use of normal Igs is based on the discoveries made by several pioneers of the field. In this paper, we review the evolution of IVIG over the years. More importantly, the process started as an s.c. replacement in γ globulin-deficient patients, underwent metamorphosis into i.m. Ig, was followed by IVIG, and is now back to s.c. forms. Following successful use of IVIG in immune thrombocytopenic purpura, there has been an explosion in the therapeutic applications of IVIG in diverse autoimmune and inflammatory conditions. In addition to clinically approved pathological conditions, IVIG has been used as an off-label drug in more than 100 different indications. The current worldwide consumption of IVIG is over 100 tons per year.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:In-Data-Review
[do] DOI:10.4049/jimmunol.1701271

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[PMID]: 29231165
[Au] Autor:Cuny C; Vaerst B; Gabrielpillai J; Tahtali A; Balster S; Lissner R; Woodcock BG
[Ti] Title:Polyvalent immunoglobulins with vitamin D3 and vitamin B12 in the treatment of Sjogren's syndrome in a vegetarian with stomatitis, glossodynia, xerostomia, and elevated antinuclear antibodies: Case report
.
[So] Source:Int J Clin Pharmacol Ther;56(1):24-27, 2018 Jan.
[Is] ISSN:0946-1965
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:BACKGROUND: Sjogren's syndrome, involving sicca symptoms with xerostomia, stomatitis, and considerable pain is a difficult-to-treat autoimmune disease where the treatment options are limited and, as in the case of methotrexate, have a low therapeutic index. CASE REPORT: This case report concerns a male patient, aged 75 years and vegetarian, with Sjogren's syndrome subsequently confirmed by salivary gland biopsy. Serum antinuclear antibodies (ANA) were elevated (1 : 320). Low serum vitamin B12 and iron levels could be improved after 20 days using vitamin B12 and iron oral supplements. Despite symptomatic treatment, xerostomia, glossitis, and glossodynia were still present, at times marked, after 12 months when the ANA titer was unchanged. Following treatment with an anti-inflammatory polyvalent immunoglobulin formulation (Lactobin®N, 7 g daily), a bovine colostrum concentrate given orally in combination with oral vitamin D3 (2,000 IU daily), sicca symptoms and xerostomia progressively decreased and at day 750 were confined to occasional and minor glossitis of the upper lip. CONCLUSION: This case report demonstrates the satisfactory control of Sjogren's syndrome using oral polyvalent immunoglobulins with vitamin D3. In contrast to treatment options involving antimalarial drugs and methotrexate, there are no safety issues in patients tolerant to milk products.
.
[Mh] MeSH terms primary: Cholecalciferol/administration & dosage
Immunoglobulins/therapeutic use
Sjogren´s Syndrome/drug therapy
Stomatitis/drug therapy
Vitamin B 12/administration & dosage
[Mh] MeSH terms secundary: Aged
Antibodies, Antinuclear/blood
Humans
Male
Sjogren's Syndrome/immunology
Stomatitis/immunology
Vegetarians
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Antibodies, Antinuclear); 0 (Immunoglobulins); 1C6V77QF41 (Cholecalciferol); P6YC3EG204 (Vitamin B 12)
[Em] Entry month:1803
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[Js] Journal subset:IM
[Da] Date of entry for processing:171213
[St] Status:MEDLINE
[do] DOI:10.5414/CP203143

  4 / 39628 MEDLINE  
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[PMID]: 29325312
[Au] Autor:Wang WJ; Sun YQ; Tang FF; Han TT; Mo XD; Wang JZ; Zhang XH; Huang XJ; Xu LP
[Ad] Address:Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing 100044, China.
[Ti] Title:[Outcomes of alternative donor allogeneic hematopoietic stem cell transplantation for Fanconi anemia: a five cases report].
[So] Source:Zhonghua Nei Ke Za Zhi;57(1):54-56, 2018 Jan 01.
[Is] ISSN:0578-1426
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:Five patients with Fanconi anemia who received hematopoietic cell transplantation were retrospectively analyzed. The conditioning regimens included fludarabine, cyclophosphamide and anti-thymocyte globulin. Two patients received both bone marrow and peripheral blood stem cells as the source of stem cell grafts from haploidentical matched related donors, while the others received peripheral blood stem cells from unrelated donors. All patients tolerated well and reached hematopoietic reconstitution. One patient died of intracranial infection. During follow-up, 4 patients survived independent of transfusion with full donor chimerism.
[Mh] MeSH terms primary: Fanconi Anemia/therapy
Graft vs Host Disease/prevention & control
Hematopoietic Stem Cell Transplantation
Transplantation Conditioning
[Mh] MeSH terms secundary: Antilymphocyte Serum/administration & dosage
Antilymphocyte Serum/therapeutic use
Bone Marrow
Cyclophosphamide/administration & dosage
Cyclophosphamide/therapeutic use
Humans
Retrospective Studies
Treatment Outcome
Unrelated Donors
Vidarabine/analogs & derivatives
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Antilymphocyte Serum); 8N3DW7272P (Cyclophosphamide); FA2DM6879K (Vidarabine); P2K93U8740 (fludarabine)
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[Js] Journal subset:IM
[Da] Date of entry for processing:180112
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0578-1426.2018.01.010

  5 / 39628 MEDLINE  
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[PMID]: 29381744
[Au] Autor:Biniaminov N; Bandt S; Roth A; Haertel S; Neumann R; Bub A
[Ad] Address:Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany.
[Ti] Title:Irisin, physical activity and fitness status in healthy humans: No association under resting conditions in a cross-sectional study.
[So] Source:PLoS One;13(1):e0189254, 2018.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Regular physical activity and physical fitness are closely related to a positive health status in humans. In this context, the muscle becomes more important due to its function as an endocrine organ. Muscle tissue secretes "myokines" in response to physical activity and it is speculated that these myokines are involved in physical activity induced positive health effects. Recently, the newly discovered myokine Irisin thought to be secreted by the muscle in response to physical activity and might be related to the health inducing effect by inducing browning of white adipose tissue. Speculating that myokines at least partly mediate exercise related health effects one would assume that regular physical activity and physical fitness are associated with resting Irisin concentrations in healthy humans. To investigate the association between resting Irisin concentration and either short-term physical activity, habitual physical activity, or physical fitness, data of 300 healthy participants from the cross-sectional KarMeN-study were analyzed. By applying different activity measurements we determined short-term and habitual physical activity, as well as physical fitness. Fasting serum samples were collected to determine resting Irisin concentrations by Enzyme-linked Immunosorbent Assay. Multivariate linear regression analysis served to investigate associations of the individual physical activity parameters with Irisin concentrations. Therefore, lean body mass and total fat mass (both determined by dual-energy X-ray absorptiometry) as well as age and parameters of glucose metabolism were included as confounders in multivariate linear regression analysis. Results showed that Irisin serum concentrations were not related to measures of physical activity and physical fitness in healthy humans under resting conditions, irrespective of the applied methods. Therefore we assume that if physical activity related effects are partly induced by myokines, permanently increased Irisin serum concentration may not be necessary to induce health-related exercise effects.
[Mh] MeSH terms primary: Fibronectins/metabolism
Physical Fitness
Rest
[Mh] MeSH terms secundary: Adolescent
Adult
Aged
Calorimetry
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Muscle, Skeletal/secretion
Young Adult
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (FNDC5 protein, human); 0 (Fibronectins)
[Em] Entry month:1802
[Cu] Class update date: 180221
[Lr] Last revision date:180221
[Js] Journal subset:IM
[Da] Date of entry for processing:180131
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189254

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[PMID]: 29297640
[Au] Autor:Kolesnikova LI; Madaeva IM; Semenova NV; Osipova EV; Darenskaya MA
[Ti] Title:Serum Myokines Levels in Patients with Endogenous Cushing Syndrome and Acromegaly: Cross-Sectional Case−Control Study.
[So] Source:Vestn Ross Akad Med Nauk;71(3):240-7, 2016.
[Is] ISSN:0869-6047
[Cp] Country of publication:Russia (Federation)
[La] Language:eng
[Ab] Abstract:Background: Myokines are produced and released by muscle cells in response to muscular contractions. Endogenous Cushing syndrome (CS) and acromegaly cause significant changes in muscle tissue leading to atrophy or hypertrophy. However, there is no data whether these endocrine abnormalities influence myokine secretion. Aims: To evaluate serum levels of myostatin, interleukin-6 (IL6) and irisin in patients with CS and acromegaly. Materials and Methods: Fasting serum samples were taken and stored in aliquot at ≤-20°C from consecutive subjects with clinically evident and biochemically confirmed active CS, acromegaly and healthy volunteers matched by age, sex and body mass index (BMI). Commercially available kits were used to assay serum myokine levels. Grip strength was measured by a dynamometer. Insulin-like growth factor-1 (IGF1) was measured by immunochemiluminescence assay (Liaison), twenty-four hours urine free cortisol (24hUFC) ­ by immunochemiluminescence assay (Vitros ECi), salivary free cortisol ­ by electrochemiluminescence assay (Cobas). One-way ANOVA was utilized to assess the difference between groups. Results: We enrolled 88 subjects: 30 patients suffered from CS (group 1), 28 ­ acromegaly (2) and 30 matched healthy controls (3) with no difference among the groups in sex, age and BMI (p=0.492, 0.062 and 0.174 respectively). Mean 24hUFC in subjects with CS and mean IGF1 in subjects with acromegaly were significantly higher as compared to other groups (p<0.001). Right-hand grip strength was lower in patients with CS as compared to both patients with acromegaly and healthy subjects (p=0.04). However, among these young adults we did not find statistically significant differences in measured myokines levels: irisin ­ p=0.15; IL6 ­ p=0.34; myostatin ­ p=0.50. There was a significant correlation between myostatin and irisin in the whole group of people and in every separately analyzed subset of patients (p<0.001), but no correlation was found between any measured myokines and 24hUFC or IGF1. Conclusions: Hypercortisolism or supraphysiological IGF1 levels do not significantly influence serum levels of myostatin, IL6 and irisin in young adults.
[Mh] MeSH terms primary: Acromegaly
Fibronectins/blood
Insulin-Like Growth Factor I
Interleukin-6/blood
Muscle, Skeletal
Myostatin/blood
[Mh] MeSH terms secundary: Acromegaly/etiology
Acromegaly/metabolism
Acromegaly/physiopathology
Adult
Cushing Syndrome/complications
Female
Humans
Insulin-Like Growth Factor I/analysis
Insulin-Like Growth Factor I/metabolism
Male
Muscle Contraction/physiology
Muscle, Skeletal/metabolism
Muscle, Skeletal/physiopathology
Statistics as Topic
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (FNDC5 protein, human); 0 (Fibronectins); 0 (Interleukin-6); 0 (Myostatin); 67763-96-6 (Insulin-Like Growth Factor I)
[Em] Entry month:1802
[Cu] Class update date: 180220
[Lr] Last revision date:180220
[Js] Journal subset:IM
[Da] Date of entry for processing:180104
[St] Status:MEDLINE
[do] DOI:10.15690/vramn659

  7 / 39628 MEDLINE  
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[PMID]: 29180294
[Au] Autor:Fortuoso BF; Volpato A; Rampazzo L; Glombowsky P; Griss LG; Galli GM; Stefani LM; Baldissera MD; Ferreira EB; Machado G; da Silva AS
[Ad] Address:Department of Animal Science, Universidade do Estado de Santa Catarina (UDESC), Brazil.
[Ti] Title:Homeopathic treatment as an alternative prophylactic to minimize bacterial infection and prevent neonatal diarrhea in calves.
[So] Source:Microb Pathog;114:95-98, 2018 Jan.
[Is] ISSN:1096-1208
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Bovine neonatal diarrhea is common due low immunity in newborn calves, poor management (or absence) of sanitary barriers, and other factors. Newborn calves with diarrhea in the first days of life suffer failure to thrive and may die if left untreated. The aim of this study was to evaluate whether prophylactic administration of a homeopathic product (Dia 100 ) can control bovine neonatal diarrhea in calves born on a farm with substantial sanitary challenges. We counted total bacteria and protozoan parasites in fecal samples. We measured serum glucose, total protein, globulin, albumin, cholesterol and triglycerides on days 1, 7 and 14 of life. Twenty newborn calves were maintained in individual stalls, and were divided in two groups: ten untreated animals (control) and ten animals treated with Dia 100 . Fecal consistency was evaluated daily. We diagnosed diarrhea in five animals in the treated group, and in all animals from the control group. Infections with Escherichia coli and Giardia duodenalis were identified as the responsible organisms. The E. coli count was low in the treatment group on day 7 of life compared with the control group. Antibiotics were given to eight animals in the control group, and to two animals in the treatment group. On day of life 7, serum levels of total protein and globulins were higher in the control group, but were lower on day 14. Serum levels of glucose and triglycerides were greater in treated animals on days 7 and 14, suggesting that the homeopathic product contributes to improvement of intestinal health and absorption and nutrients. We conclude that Dia 100 controls diarrhea with 50% of efficacy, and reduces antibiotic utilization.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 180218
[Lr] Last revision date:180218
[St] Status:In-Process

  8 / 39628 MEDLINE  
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Clinical Trials Registry
Clinical Trials Registry
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[PMID]: 27779572
[Au] Autor:Lee D; Keymeulen B; Hilbrands R; Ling Z; Van de Velde U; Jacobs-Tulleneers-Thevissen D; Maleux G; Lapauw B; Crenier L; De Block C; Mathieu C; Pipeleers D; Gillard P
[Ad] Address:1 Department of Clinical and Experimental Medicine, Katholieke Universiteit Leuven and University Hospitals Leuven, Leuven, Belgium. 2 University Hospital and Diabetes Research Center, Vrije Universiteit Brussel (VUB), Brussels, Belgium. 3 Department of Interventional Radiology, University Hospitals Leuven, KUL, Leuven, Belgium. 4 Department of Endocrinology, Gent University Hospital, Gent, Belgium. 5 Department of Endocrinology, Université Libre de Bruxelles-Hôpital Erasme, Bruxelles, Belgium. 6 Department of Diabetology, University Hospital Antwerp-UA, Antwerp, Belgium.
[Ti] Title:Age and Early Graft Function Relate With Risk-Benefit Ratio of Allogenic Islet Transplantation Under Antithymocyte Globulin-Mycophenolate Mofetil-Tacrolimus Immune Suppression.
[So] Source:Transplantation;101(9):2218-2227, 2017 09.
[Is] ISSN:1534-6080
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Induction therapy with a T cell-depleting agent followed by mycophenolate mofetil and tacrolimus is presently the most frequently used immune suppression (IS) regimen in islet transplantation. This study assesses its safety and tolerability in nonuremic type 1 diabetic recipients. METHODS: Fifty-one patients (age, between 29 and 63 years) with high glycemic variability and problematic hypoglycemia received intraportal islet grafts under anti-thymocyte globulin-mycophenolate mofetil-tacrolimus protocol. They were followed up for over 48 months for function of the implant and adverse events. RESULTS: Severe hypoglycemia and diabetic ketoacidosis were absent in patients with functioning graft. Immune suppressive therapy was maintained for 48 months in 29 recipients with sustained function (group A), whereas 16 patients stopped earlier due to graft failure (group B) and in 6 for other reasons. Group A was significantly older at the time of implantation and achieved higher graft function at posttransplantation month 6 under similar dose of IS. Prevalence of IS-related side effects was similar in groups A and B, occurring predominantly during the first year posttransplantation. IS-related serious adverse events (SAE) were reported in 47% of patients, with 4 presenting with cytomegalovirus infection and 4 (age, 42-59 years) diagnosed with cancer. Except in 1 patient with cancer, all SAEs resolved after appropriate treatment. CONCLUSIONS: These risk/benefit data serve as a basis for clinical decision-making before entering an intraportal islet transplantation protocol. A longer benefit is observed in recipients of higher age (≥40 years), but it is not associated with more side effects and SAE.
[Mh] MeSH terms primary: Antilymphocyte Serum/therapeutic use
Diabetes Mellitus, Type 1/surgery
Immunosuppressive Agents/therapeutic use
Islets of Langerhans Transplantation
Mycophenolic Acid/therapeutic use
Tacrolimus/therapeutic use
[Mh] MeSH terms secundary: Adult
Antilymphocyte Serum/adverse effects
Biomarkers/blood
Blood Glucose/metabolism
C-Peptide/blood
Diabetes Mellitus, Type 1/blood
Drug Therapy, Combination
Female
Humans
Immunosuppressive Agents/adverse effects
Islets of Langerhans Transplantation/adverse effects
Male
Middle Aged
Mycophenolic Acid/adverse effects
Postoperative Complications/etiology
Risk Assessment
Risk Factors
Tacrolimus/adverse effects
Time Factors
Transplantation, Homologous
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Antilymphocyte Serum); 0 (Biomarkers); 0 (Blood Glucose); 0 (C-Peptide); 0 (Immunosuppressive Agents); D7RD81HE4W (thymoglobulin); HU9DX48N0T (Mycophenolic Acid); WM0HAQ4WNM (Tacrolimus)
[Em] Entry month:1710
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[Js] Journal subset:IM
[Da] Date of entry for processing:161026
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1097/TP.0000000000001543

  9 / 39628 MEDLINE  
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[PMID]: 29194778
[Au] Autor:Ribatti D
[Ad] Address:Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy.
[Ti] Title:A historical perspective on milestones in multiple myeloma research.
[So] Source:Eur J Haematol;100(3):221-228, 2018 Mar.
[Is] ISSN:1600-0609
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The first well-documented case of multiple myeloma was reported in 1844 by Samuel Solly. In this article, the author presents a historical review of the disease. In particular, the review is focused on the main steps, including the definition of Bence Jones proteinuria, the characterization of tumoral plasma cells and serum globulins, and the fundamental contribution of Jan Waldenstrom. Finally, treatment of multiple myeloma, as well as the development of new agents, is discussed.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1712
[Cu] Class update date: 180215
[Lr] Last revision date:180215
[St] Status:In-Process
[do] DOI:10.1111/ejh.13003

  10 / 39628 MEDLINE  
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[PMID]: 29364544
[Au] Autor:Lescano J; Quevedo M; Villalobos M; Gavidia CM
[Ad] Address:Laboratory of Animal Anatomy and Wildlife, School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru.
[Ti] Title:Hematology and serum biochemistry of free-ranging and captive Sechuran foxes (Lycalopex sechurae).
[So] Source:Vet Clin Pathol;, 2018 Jan 24.
[Is] ISSN:1939-165X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Hematologic and serum biochemical reference values obtained from captive or free-ranging wildlife populations may not be comparable as there can be significant variations due to preanalytic and analytic differences, including methods of capture and restraint, overall management in captivity including diet and composition of animal groups, and analytic methods being used. Hematology and serum biochemistry have never been studied in captive or free-ranging populations of Sechuran foxes (Lycalopex sechurae). OBJECTIVES: The purposes of the study were to determine hematologic and serum biochemical RI in Sechuran foxes and to explore differences in these variables related to sex and overall life circumstances. METHODS: Blood samples were obtained from 15 free-ranging and 15 captive Sechuran foxes. Hematology variables were assessed by blood smear examination and automated analyzer methodology. Serum biochemical analysis was performed by automated analyzer methodology. Descriptive statistics were calculated for each variable. Data obtained from free-ranging and captive groups were statistically compared and RIs were calculated. RESULTS: Captive Sechuran foxes had significantly (P < .05) higher MCH, MCHC, and eosinophil counts and significantly lower band neutrophil counts than free-ranging foxes. Free-ranging Sechuran foxes had significantly (P < .05) higher serum lipase and globulins and significantly lower albumin, total bilirubin, and indirect bilirubin than captive foxes. CONCLUSIONS: These findings suggest that there are hematologic and serum biochemical differences between captive and free-ranging Sechuran fox populations. Hence, such differences should be considered when using these variables to assess the health status of this species.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180124
[Lr] Last revision date:180124
[St] Status:Publisher
[do] DOI:10.1111/vcp.12568


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