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[PMID]: 29495285
[Au] Autor:Guo W; Dong H; Wang D; Yang B; Wang X; Huang L
[Ad] Address:School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, 4655 Daxue Road, Jinan 250355, China. weiguo1982@126.com.
[Ti] Title:Separation of Seven Polyphenols from the Rhizome of Smilax glabra by Offline Two Dimension Recycling HSCCC with Extrusion Mode.
[So] Source:Molecules;23(2), 2018 Feb 24.
[Is] ISSN:1420-3049
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:An offline two-dimensional recycling high-speed countercurrent chromatography (2D R-HSCCC) strategy with extrusion mode was developed for isolating polyphenols from the rhizome of . Firstly, the ethyl acetate extract was divided into two fractions, Fr.1 and Fr.2, by silica gel column chromatography. Then, HSCCC was applied to separate polyphenols from the two fractions using a solvent system consisting of petroleum ether-ethyl acetate-methanol-water (1:3:0.5:5, / ). Fifty milligrams of Fr.1 was separated by conventional HSCCC, yielding 5- -caffeoylshikimic acid ( , 15.8 mg) and taxifolin ( , 4.8 mg). Offline 2D R-HSCCC with extrusion mode was used to separate Fr.2, and astilbin ( , 37.3 mg), neoisoastilbin ( , 8.8 mg), engeletin ( , 7.9 mg), and a mixture of two polyphenols were obtained from 100 mg of Fr.2. The mixture of two polyphenols was further separated by pre-HPLC, yielding neoastilbin ( , 15.2 mg) and isoastilbin ( , 9.9 mg). The purities of these seven compounds were all over 96.0%. Their structures were identified by MS and NMR. The results demonstrated that the strategy based on offline 2D R-HSCCC with extrusion mode was a powerful tool to separate the main compounds from the rhizome of and valued for the preparative separation compounds with broad -values and similar structures.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:In-Process

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[PMID]: 29458848
[Au] Autor:El-Sayed ASA; Akbar A; Iqrar I; Ali R; Norman D; Brennan M; Ali GS
[Ad] Address:Mid-Florida Research and Education Center, Department of Plant pathology, University of Florida/Institute of Food and Agricultural Sciences, Apopka, FL, USA; Microbiology and Botany Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.
[Ti] Title:A glucanolytic Pseudomonas sp. associated with Smilax bona-nox L. displays strong activity against Phytophthora parasitica.
[So] Source:Microbiol Res;207:140-152, 2018 Mar.
[Is] ISSN:1618-0623
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Biological control is an eco-friendly strategy for mitigating and controlling plant diseases with negligible effects on human health and environment. Biocontrol agents are mostly isolated from field crops, and microbiomes associated with wild native plants is underexplored. The main objective of this study was to characterize the bacterial isolates associated with Smilax bona-nox L, a successful wild plant with invasive growth habits. Forty morphologically distinct bacterial isolates were recovered from S. bona-nox. Based on 16S rRNA gene sequencing, these isolates belonged to 12 different genera namely Burkholderia, Pseudomonas, Xenophilus, Stenotrophomonas, Pantoea, Enterobactriaceae, Kosakonia, Microbacterium, Curtobacterium, Caulobacter, Lysinibacillus and Bacillus. Among them, Pseudomonas sp. EA6 and Pseudomonas sp. EA14 displayed the highest potential for inhibition of Phytophthora. Based on sequence analysis of rpoD gene, these isolates revealed a 97% identity with a Pseudomonas fluorescence strain. Bioactivity-driven assays for finding bioactive compounds revealed that crude proteins of Pseudomonas sp. EA6 inhibited mycelial growth of P. parasitica, whereas crude proteins of Pseudomonas sp. EA14 displayed negligible activity. Fractionation and enzymatic analyses revealed that the bioactivity of Pseudomonas sp. EA6 was mostly due to glucanolytic enzymes. Comparison of chromatographic profile and bioactivity assays indicated that the secreted glucanolytic enzymes consisted of ß-1,3 and ß-1,4 glucanases, which acted together in hydrolyzing Phytophthora cell walls. Since the biological activity of the crude glucanolytic extract was >60-fold higher than the purified ß-1,3 glucanase, the glucanolytic enzyme system of Pseudomonas sp. EA6 likely acts synergistically in cell wall hydrolysis of P. parasitica.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180220
[Lr] Last revision date:180220
[St] Status:In-Process

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[PMID]: 29453916
[Au] Autor:Liang J; Zhou M; Li LY; Shu JC; Liang YH; Li FQ; Xiong L; Huang HL
[Ad] Address:1University of Traditional Chinese Medicine Nanchang, 330004, China.
[Ti] Title:Distinguishing Smilax glabra and Smilax china rhizomes by flow-injection mass spectrometry combined with principal component analysis.
[So] Source:Acta Pharm;68(1):87-96, 2018 Mar 01.
[Is] ISSN:1846-9558
[Cp] Country of publication:Croatia
[La] Language:eng
[Ab] Abstract:Flow-injection mass spectrometry (FIMS) coupled with a chemometric method is proposed in this study to profile and distinguish between rhizomes of Smilax glabra (S. glabra) and Smilax china (S. china). The proposed method employed an electrospray-time-of-flight MS. The MS fingerprints were analyzed using principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) with the aid of SIMCA software. Findings showed that the two kinds of samples perfectly fell into their own classes. Further predictive study showed desirable predictability and the tested samples were successfully and reliably identified. The study demonstrated that the proposed method could serve as a powerful tool for distinguishing between S. glabra and S. china.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180217
[Lr] Last revision date:180217
[St] Status:In-Process

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[PMID]: 29433390
[Au] Autor:Hua S; Zhang Y; Liu J; Dong L; Huang J; Lin D; Fu X
[Ad] Address:* School of Pharmacy, Ningxia Medical University, Yinchuan 750004, P. R. China.
[Ti] Title:Ethnomedicine, Phytochemistry and Pharmacology of Smilax glabra: An Important Traditional Chinese Medicine.
[So] Source:Am J Chin Med;:1-37, 2018 Feb 12.
[Is] ISSN:0192-415X
[Cp] Country of publication:Singapore
[La] Language:eng
[Ab] Abstract:Smilax glabra (SG) Roxb., a well-known traditional Chinese medicine, has been extensively used worldwide for its marked pharmacological activities for treating syphilitic poisoned sores, limb hypertonicity, morbid leucorrhea, eczema pruritus, strangury due to heat, carbuncle toxin, and many other human ailments. Approximately 200 chemical compounds have been isolated from SG Roxb., and the major components have been determined to be flavonoids and flavonoid glycosides, phenolic acids, and steroids. Among these active compounds, the effects of astilbin, which is used as a quality control marker to determine the quality of SG Roxb., have been widely investigated. Based on in vivo and in vitro studies, the primary active components of SG Roxb. possess various pharmacological activities, such as cytotoxic, anti-inflammatory and immune-modulatory effects, anti-oxidant, hepatoprotective, antiviral, antibacterial, and cardiovascular system protective activities. However, an extensive study to determine the relationship between the chemical compositions and pharmacological effects of SG Roxb. has not been conducted and is worth of our study. Improving the means of utilizing the effects of SG is crucial. The present paper reviews the ethnopharmacology, phytochemistry, and pharmacology of SG Roxb. and assesses its ethnopharmacological use in order to explore its therapeutic potential for future research.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[St] Status:Publisher
[do] DOI:10.1142/S0192415X18500143

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[PMID]: 29149807
[Au] Autor:Shu J; Li L; Zhou M; Yu J; Peng C; Shao F; Liu R; Zhu G; Huang H
[Ad] Address:a Key Laboratory of Modern Preparation of TCM , Jiangxi University of Traditional Chinese Medicine, Ministry of Education , Nanchang , China.
[Ti] Title:Three new flavonoid glycosides from Smilax glabra and their anti-inflammatory activity.
[So] Source:Nat Prod Res;:1-9, 2017 Nov 17.
[Is] ISSN:1478-6427
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Three new flavonoid glycosides, 2(S)-5-hydroxy-6,8-dimethoxyflavonone-7-O-ß-D-glucopyranosyl-(1→6)-O-ß-D-glucopyranoside (1), 5-hydroxy-3,8-dimethoxyflavone-7-O-ß-D-glucopyranosyl-(1→6)-O-ß-D-glucopyranoside (2) and 3,7-dihydroxy-8-methoxyflavone-6-O-ß-D-glucopyranosyl-(1→6)-O-ß-D-glucopyranoside (3), together with five known flavonoids (4-8) were isolated from the roots of Smilax glabra Roxb. Their structures were elucidated on the basis of chemical and spectral evidence, as well as by comparison with literature data. Three new flavonoids were subjected to evaluate anti-inflammatory activity. Compounds 1-3 inhibited the NF κB induction by 32.2, 55.8 and 61.7%, respectively.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171118
[Lr] Last revision date:171118
[St] Status:Publisher
[do] DOI:10.1080/14786419.2017.1402314

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[PMID]: 29111814
[Au] Autor:She T; Feng J; Lian S; Li R; Zhao C; Song G; Luo J; Dawuti R; Cai S; Qu L; Shou C
[Ad] Address:a Department of Clinical Immunology, School of Medical Laboratory , Tianjin Medical University , Tianjin , China.
[Ti] Title:Sarsaparilla (Smilax Glabra Rhizome) Extract Activates Redox-Dependent ATM/ATR Pathway to Inhibit Cancer Cell Growth by S Phase Arrest, Apoptosis, and Autophagy.
[So] Source:Nutr Cancer;:1-9, 2017 Nov 07.
[Is] ISSN:1532-7914
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Sarsaparilla (Smilax Glabra Rhizome) exerts growth inhibitory effect on multiple cancer cells in vitro and in vivo, and redox-dependent persistent activation of ERK1/2 has been reported to underlie this effect. Here, we report an activation of ATM/ATR-dependent signaling pathway also as a mechanism for the cancer cell growth inhibition induced by the supernatant fraction of the water-soluble extract from sarsaparilla (SW). SW treatment (3.5 µg/µL) promoted the phosphorylations of ATM, ATR, and CHK1 in AGS and HT-29 cells. The ATM kinase inhibitor, KU55933, could reverse SW-induced ERK phosphorylation but not the reduced glutathione/oxidized glutathione (GSH/GSSG) imbalance in AGS cells. However, both the redox inhibitor glutathione (GSH) and ERK inhibitor U0126 antagonized SW-induced phosphorylations of ATM, ATR, and CHK1 in AGS cells. We further found KU55933 significantly antagonized SW-induced S phase arrest, apoptosis, autophagy and the resultant cell growth inhibition. Our results provide another molecular basis for the anticancer action of sarsaparilla.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171107
[Lr] Last revision date:171107
[St] Status:Publisher
[do] DOI:10.1080/01635581.2017.1362447

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[PMID]: 28944899
[Au] Autor:Li Y; Deng S; Ζhao Y; Liu L; Zhao R
[Ad] Address:Key Research Laboratory of Gynecology, Department of Gynecology, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510120, P.R. China.
[Ti] Title:Smilax glabra Rhizoma affects the pharmacokinetics and tissue distribution of methotrexate by increasing the P­glycoprotein mRNA expression in rats after oral administration.
[So] Source:Mol Med Rep;16(5):7633-7640, 2017 Nov.
[Is] ISSN:1791-3004
[Cp] Country of publication:Greece
[La] Language:eng
[Ab] Abstract:Methotrexate (MTX) is a widely used immunosuppressant and anticancer agent with high toxicity. Smilax glabra Rhizoma (SGR) has the effect of detoxification and immunoregulation, and has been used as both food and folk medicine in many countries. Co­administration of MTX and SGR occurs in several diseases. However, whether they work synergistically or are incompatible remains unknown. In the present study, MTX was administrated to rats alone or combined with SGR. Blood and tissue samples were collected at designated times. The concentrations of MTX were determined by high­performance liquid chromatography. Reverse transcription­quantitative polymerase chain reaction (RT­qPCR) was used to detected the gene expression. SGR decreased the AUC0­t and Cmax of MTX by 44.5 and 48.2%, but in a tissue­dependent manner. The total exposure of MTX was significantly decreased in the small intestine, stomach, plasma, and kidney by 61.6, 34.7, 63.3 and 46.1%, respectively, but was increased in the lung and spleen by 82.9 and 21.0%, respectively. RT­qPCR demonstrated that SGR increased the mean P­glycoprotein (gp) mRNA expression in the small intestine 2.54 times, but had a marginal effect on the expression of organic anion transporting polypeptide 2, and organic anion transporter (OAT)1 and OAT2. These results suggested that SGR affects the pharmacokinetics of MTX in a tissue­dependent manner by affecting P­gp, and the clinical effect of co­administration depended on the disease site.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 171020
[Lr] Last revision date:171020
[St] Status:In-Process
[do] DOI:10.3892/mmr.2017.7559

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[PMID]: 28870851
[Au] Autor:Zhou M; Huang L; Li L; Wei Y; Shu J; Liu X; Huang H
[Ad] Address:Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
[Ti] Title:New furostanol saponins with anti-inflammatory and cytotoxic activities from the rhizomes of Smilax davidiana.
[So] Source:Steroids;127:62-68, 2017 Nov.
[Is] ISSN:1878-5867
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Seven new furostanol saponins have been isolated from the rhizomes of Smilax davidiana. Their structures were established by 2D NMR spectroscopic techniques ( H, H-COSY, NOESY, HSQC and HMBC), mass spectrometry and comparison with the literature. The isolated compounds were subjected to evaluate anti-inflammatory and cytotoxic activities in vitro. Compounds 3, 5 and 7 were found to have modest anti-inflammatory effects through suppression of IL-1ß production and promote the expression of IL-10 in LPS-stimulated RAW 264.7 cells. Davidianoside F (6) showed activity against MCF-7 and HELA cell lines at the concentration of 10.2µM and 4.3µM, respectively.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 171004
[Lr] Last revision date:171004
[St] Status:In-Process

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[PMID]: 28756918
[Au] Autor:Duong NT; Vinh PD; Thuong PT; Hoai NT; Thanh LN; Bach TT; Nam NH; Anh NH
[Ad] Address:Department of Pharmacology, Hanoi University of Pharmacy, 13 Le Thanh Tong, Hoan Kiem, Hanoi, Viet Nam.
[Ti] Title:Xanthine oxidase inhibitors from Archidendron clypearia (Jack.) I.C. Nielsen: Results from systematic screening of Vietnamese medicinal plants.
[So] Source:Asian Pac J Trop Med;10(6):549-556, 2017 Jun.
[Is] ISSN:2352-4146
[Cp] Country of publication:China
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To screen Vietnamese medicinal plants for xanthine oxidase (XO) inhibitory activity and to isolate XO inhibitor(s) from the most active plant. METHODS: The plants materials were extracted by methanol. The active plant materials were fractionated using different organic solvents, including n-hexane, ethyl acetate, and n-butanol. Bioassay-guided fractionation and column chromatography were used to isolate compounds. The compounds structures were elucidated by analysis of spectroscopic data, including IR, MS, and NMR. RESULTS: Three hundreds and eleven methanol extracts (CME) belonging to 301 Vietnamese herbs were screened for XO inhibitory activity. Among these plants, 57 extracts displayed XO inhibitory activity at 100 µg/mL with inhibition rates of over 50%. The extracts of Archidendron clypearia (A. clypearia), Smilax poilanei, Linociera ramiflora and Passiflora foetida exhibited the greatest potency with IC values below 30 µg/mL. Chemical study performed on the extract of A. clypearia resulted in the isolation of six compounds, including 1-octacosanol, docosenoic acid, daucosterol, methyl gallate, quercitrin and (-)-7-O-galloyltricetiflavan. The compound (-)-7-O-galloyltricetiflavan showed the most potent XO inhibitory activity with an IC value of 25.5 µmol/L. CONCLUSIONS: From this investigation, four Vietnamese medicinal plants were identified to have XO inhibitory effects with IC values of the methanol extracts below 30 µg/mL. Compound (-)-7-O- galloyltricetiflavan was identified as an XO inhibitor from A. clypearia with IC value of 25.5 µmol/L.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170731
[Lr] Last revision date:170731
[St] Status:In-Data-Review

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[PMID]: 28725220
[Au] Autor:Wang LW; Wang JL; Chen J; Chen JJ; Shen JW; Feng XX; Kubicek CP; Lin FC; Zhang CL; Chen FY
[Ad] Address:Department of Pharmaceutical Science, College of Medical Science, Hangzhou Normal UniversityHangzhou, China.
[Ti] Title:A Novel Derivative of (-)mycousnine Produced by the Endophytic Fungus , Exhibits High and Selective Immunosuppressive Activity on T Cells.
[So] Source:Front Microbiol;8:1251, 2017.
[Is] ISSN:1664-302X
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:An endophytic fungus, ZJLQ129, was isolated from the leaves of the traditional Chinese medicine Smilax china. From the fermentation broth and mycelium, a dibenzofurane compound (-)mycousnine (1) was isolated. Chemical modification of it to the amide derivative (-)mycousnine enamine (2), which is new to science, was found to have high and selective immunosuppressive activity: similar to cyclosporin A, (-)mycousnine enamine (2) selectively inhibited T cell proliferation, suppressed the expression of the surface activation antigens CD25 and CD69 and the formation and expression of the cytokines interleukin-2 as well as interferon γ in activated T cells, but did not show any effect on the proliferation of B cells and cancer cells (PANC-1 and A549) and the activation of macrophages. Furthermore, the cytotoxicity of (-)mycousnine enamine was lower than that of cyclosporin A, and its therapeutic index (TC50/EC50) was 4,463.5, which is five-fold higher than that of cyclosporin A. We conclude that (-)mycousnine enamine (2), the semi-synthestic product prepared from the native product (-)mycousnine (1) of the endophyte M. nawae is a novel effective immunosuppressant showing low toxicity and high selectivity.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170723
[Lr] Last revision date:170723
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.3389/fmicb.2017.01251


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