Database : MEDLINE
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[PMID]: 28455256
[Au] Autor:Kim JH; Cho CW; Kim HY; Kim KT; Choi GS; Kim HH; Cho IS; Kwon SJ; Choi SK; Yoon JY; Yang SY; Kang JS; Kim YH
[Ad] Address:College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea; Department of Horticultural and Crop Environment, National Institute of Horticultural and Herbal Science, RDA, Wanju, 55365, Republic of Korea; Advanced Radiation Technology Institute, Korea Atomic Energy Research I
[Ti] Title:α-Glucosidase inhibition by prenylated and lavandulyl compounds from Sophora flavescens roots and in silico analysis.
[So] Source:Int J Biol Macromol;102:960-969, 2017 Sep.
[Is] ISSN:1879-0003
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:The enzyme α-glucosidase is a good drug target for the treatment of diabetes mellitus. Four minor flavonoids (1-4) from roots of Sophora flavescens showed the inhibitory activity, with IC values ranging from 11.0±0.3 to 50.6±1.3µM, toward α-glucosidase. An enzyme kinetics analysis of them revealed that the compounds 1 and 4 were non-competitive, and compounds 2 and 3 were un-competitive inhibitors. For molecular docking, 3-dimensional structure of α-glucosidase was built by homology modeling. As the result, four compounds 1-4 were confirmed to interact into common binding site of α-glucosidase. In addition, all of the four prenylated and lavandulyl compounds (1-4) were abundant in an ethyl acetate fraction separated from a methanol extract, and the potential inhibitor (3) was extracted best using tetrahydrofuran.
[Mh] MeSH terms primary: Computer Simulation
Plant Extracts/pharmacology
Plant Roots/chemistry
Prenylation
Sophora/chemistry
Terpenes/chemistry
alpha-Glucosidases/metabolism
[Mh] MeSH terms secundary: Amino Acid Sequence
Glycoside Hydrolase Inhibitors/chemistry
Glycoside Hydrolase Inhibitors/metabolism
Glycoside Hydrolase Inhibitors/pharmacology
Molecular Docking Simulation
Plant Extracts/chemistry
Plant Extracts/metabolism
Protein Conformation
alpha-Glucosidases/chemistry
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Glycoside Hydrolase Inhibitors); 0 (Plant Extracts); 0 (Terpenes); EC 3.2.1.20 (alpha-Glucosidases)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:170430
[St] Status:MEDLINE

  2 / 1083 MEDLINE  
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[PMID]: 29500453
[Au] Autor:Liu D; Chan BC; Cheng L; Tsang MS; Zhu J; Wong CW; Jiao D; Chan HY; Leung PC; Lam CW; Wong CK
[Ad] Address:Institute of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, China.
[Ti] Title:Sophora flavescens protects against mycobacterial Trehalose Dimycolate-induced lung granuloma by inhibiting inflammation and infiltration of macrophages.
[So] Source:Sci Rep;8(1):3903, 2018 Mar 02.
[Is] ISSN:2045-2322
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The immune system responds to Mycobacterium tuberculosis (MTB) infection by forming granulomas to quarantine the bacteria from spreading. Granuloma-mediated inflammation is a cause of lung destruction and disease transmission. Sophora flavescens (SF) has been demonstrated to exhibit bactericidal activities against MTB. However, its immune modulatory activities on MTB-mediated granulomatous inflammation have not been reported. In the present study, we found that flavonoids from Sophora flavescens (FSF) significantly suppressed the pro-inflammatory mediators released from mouse lung alveolar macrophages (MH-S) upon stimulation by trehalose dimycolate (TDM), the most abundant lipoglycan on MTB surface. Moreover, FSF reduced adhesion molecule (LFA-1) expression on MH-S cells after TDM stimulation. Furthermore, FSF treatment on TDM-activated lung epithelial (MLE-12) cells significantly downregulated macrophage chemoattractant protein (MCP-1/CCL2) expression, which in turn reduced the in vitro migration of MH-S to MLE-12 cells. In addition, FSF increased the clearance of mycobacterium bacteria (Mycobacterium aurum) in macrophages. FSF mainly affected the Mincle-Syk-Erk signaling pathway in TDM-activated MH-S cells. In TDM-induced mouse granulomas model, oral administration with FSF significantly suppressed lung granulomas formation and inflammation. These findings collectively implicated an anti-inflammatory role of FSF on MTB-mediated granulomatous inflammation, thereby providing evidence of FSF as an efficacious adjunct treatment during mycobacterial infection.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Data-Review
[do] DOI:10.1038/s41598-018-22286-w

  3 / 1083 MEDLINE  
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[PMID]: 28748727
[Au] Autor:Yan S; Pan S; Ji J
[Ad] Address:a School of Petrochemical Engineering , Changzhou University , Changzhou , PR China.
[Ti] Title:Silk fabric dyed with extract of sophora flower bud.
[So] Source:Nat Prod Res;32(3):308-315, 2018 Feb.
[Is] ISSN:1478-6427
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:This study analysed the use of sophora flower bud extract for dyeing and the resulting colour character and fastness of dyed silk fabric. The pigment composition on the silk fabric and recycling of this extract were also studied. The results indicated that the dyed silk fabric possessed good washing, rubbing and perspiration fastness, and the pigment composition on the silk fabric was mainly rutin and quercetin. The average recovery rate of the dye was 55.00%. These results demonstrate that the sophora flower bud extract is an effective natural dye.
[Mh] MeSH terms primary: Coloring Agents/chemistry
Plant Extracts/chemistry
Silk/chemistry
Sophora/chemistry
Textiles
[Mh] MeSH terms secundary: Chemical Precipitation
Chromatography, High Pressure Liquid
Coloring Agents/analysis
Flowers/chemistry
Magnetic Resonance Spectroscopy
Plant Extracts/analysis
Quercetin/analysis
Rutin/analysis
Spectroscopy, Fourier Transform Infrared
Textiles/analysis
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Coloring Agents); 0 (Plant Extracts); 0 (Silk); 5G06TVY3R7 (Rutin); 9IKM0I5T1E (Quercetin)
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:IM
[Da] Date of entry for processing:170728
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1359170

  4 / 1083 MEDLINE  
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[PMID]: 29481011
[Au] Autor:Aghvami M; Ebrahimi F; Zarei MH; Salimi A; Pourahmad Jaktaji R; Pourahmad J
[Ad] Address:Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Email: j.pourahmadjaktaji@utoronto.ca, razieh_jaktaji@yahoo.com
[Ti] Title:Matrine Induction of ROS Mediated Apoptosis in Human ALL B-lymphocytes Via Mitochondrial Targeting
[So] Source:Asian Pac J Cancer Prev;19(2):555-560, 2018 Feb 26.
[Is] ISSN:2476-762X
[Cp] Country of publication:Thailand
[La] Language:eng
[Ab] Abstract:Background: Acute lymphoblastic leukemia (ALL) is one of the most common malignancies among children, characterized by mass production of leukemic blasts. Chemotherapy is the first step in routine treatment, although it may evoke considerable side effects. Matrine, an alkaloid extracted from a Chinese herb, Sophora alopecuroides flavescens Ait, may be protective. Several investigations have indicated pro-apoptotic and anti-proliferative effects in a diverse range of cancer cells. Methods: Matrine's anti-cancer effects and associated mechanisms were assessed in human ALL B-lymphocytes, focusing on parameters of inflammatory change and apoptosis. Results: Treatment of ALL B-lymphocytes with matrine augmented ROS generation, and caused mitochondrial swelling and a decline in mitochondrial membrane potential. Significant up-regulation of the pro-apoptotic protein Bax and down-regulation of the anti-apoptotic Bcl-2 were also noted. Conclusion: Our results suggest that matrine may be a potential anticancer agent. However, additional studies are needed to clarify involved mechanisms.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180226
[Lr] Last revision date:180226
[St] Status:In-Process

  5 / 1083 MEDLINE  
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[PMID]: 29241159
[Au] Autor:Liang J; Chang B; Huang M; Huang W; Ma W; Liu Y; Tai W; Long Y; Lu Y
[Ad] Address:Collaborative Innovation Center of Miao medicine, Guiyang College of Traditional Chinese Medicine, Guiyang, Guizhou, China. Electronic address: liangjiang1573@hotmail.com.
[Ti] Title:Oxymatrine prevents synovial inflammation and migration via blocking NF-κB activation in rheumatoid fibroblast-like synoviocytes.
[So] Source:Int Immunopharmacol;55:105-111, 2018 Feb.
[Is] ISSN:1878-1705
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:The fibroblast-like synoviocytes (FLSs) has the aggressive phenotype, which is very important for cartilage destruction in rheumatoid arthritis (RA). To the pathology of RA, the increased FLSs migration, activation and proliferation are essential factors. Oxymatrine is a traditional Chinese herb, which is the extraction from the root of Sophora flavescens and regarded as quinolizidine alkaloid compounds and has been shown to inhibit inflammation, proliferation and migration in vitro or vivo. However, whether oxymatrine effects in the treatment of RA FLSs is undefined. In our study, the inhibition of oxymatrine in RA FLSs inflammation, proliferation and migration in RA FLS are evaluated. We found that oxymatrine decreased the IL-6 and IL-8 expression and the proliferation, migration and invasion of RA FLSs. We also evaluated the molecular mechanisms and we found the effect of oxymatrine on NF-κB activation. The results showed that oxymatrine inhibited the activity of NF-κB. And the treatment activity of oxymatrine on collagen-induced arthritis (CIA) was further explored by us. Thus, we conclude that oxymatrine may protect joint destruction of RA by inhibiting synoviocyte activation, migration, invasion, and proliferation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180221
[Lr] Last revision date:180221
[St] Status:In-Process

  6 / 1083 MEDLINE  
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[PMID]: 29356020
[Au] Autor:Huang H; Wang Q; Du T; Lin C; Lai Y; Zhu D; Wu W; Ma X; Bai S; Li Z; Liu L; Li Q
[Ad] Address:Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
[Ti] Title:Matrine inhibits the progression of prostate cancer by promoting expression of GADD45B.
[So] Source:Prostate;78(5):327-335, 2018 Apr.
[Is] ISSN:1097-0045
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Matrine is a naturally occurring alkaloid extracted from the Chinese herb Sophora flavescens. It has been demonstrated to exhibit antiproliferative properties, promote apoptosis, and inhibit cell invasion in a number of cancer cell lines by modulating the NF-κB pathway to downregulate the expression of MMP2 and MM9. It has also been shown to improve the efficacy of chemotherapy when it is combined with other chemotherapy drugs. However, the therapeutic potential of matrine for prostate cancer needs to be further studied. METHODS: We analyzed KEGG pathways of differential gene expression between matrine-treated and untreated prostate cancer cell lines and identified GADD45B as one of major target genes of matrine based on its role in apoptosis and prognosis value for prostate cancer patients in TCGA database. We further analyzed the expression of GADD45B protein in a tissue microarray and mRNA in TCGA database, and tested the synergistic impacts of matrine and GADD45B overexpression on proliferation, apoptosis, migration and invasion of prostate cancer cell DU145. RESULTS: Matrine promoted the expression of GADD45B, a tumor suppressive gene that is involved in the regulation of cell cycle, DNA damage repair, cell survival, aging, apoptosis and other cellular processes through p38/JNK, ROS-GADD45B-p38, or other signal pathways. Although GADD45B is elevated in prostate cancer tissues, levels of GADD45B in prostate tumor tissues are reduced at late stage of tumor invasion, and higher levels of GADD45B predict better survivals of prostate cancer patients. CONCLUSIONS: Matrine may be used to treat prostate cancer patients to increase the levels of GADD45B to inhibit tumor invasion and improve patient survivals.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180220
[Lr] Last revision date:180220
[St] Status:In-Data-Review
[do] DOI:10.1002/pros.23469

  7 / 1083 MEDLINE  
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[PMID]: 29442052
[Au] Autor:Tang Z; Wang Q; He Z; Yin L; Zhang Y; Wang S
[Ti] Title:Liver, blood microdialysate and plasma pharmacokinetics of matrine following transdermal or intravenous administration.
[So] Source:Pharmazie;72(3):167-170, 2017 Mar 01.
[Is] ISSN:0031-7144
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Matrine is contained in several herbs used in traditional Chinese medicine, named Sophora alopecuroides, Sophora flavescens or Sophora subprostrata. In vitro and in vivo studies have focused on the treatment of chronic hepatitis or liver fibrosis using matrine. However, little is known about its liver pharmacokinetic profile. In this study pharmacokinetics of matrine in rat organs and tissues, such as liver, blood and skin were studied after intravenous (40 mg/kg) or transdermal administration (6 mg/cm2, 5 cm2). Samples were collected at timed intervals for measurement of matrine by a HPLC-UV method. The pharmacokinetic parameters were calculated by non-compartmental analysis using DAS 2.0. The AUC(0-t) values in the liver, blood microdialysates and plasma after intravenous administration were 395.91±74.48, 848.86±146.35 and 1304.07±305.92 min·mg/l, respectively. Following transdermal administration, the AUC(0-t) value in the liver, blood, plasma and skin microdialysates were 695.30±233.79, 1096.07±390.71, 2767.57±518.48 and 42735.77±27938.33 min·mg/l, respectively. Here, we show a promising delivery system for matrine that could replace traditional administration, and a better understanding of the transdermal pharmacokinetics of matrine, which may be helpful for further clinical and laboratory studies.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180214
[Lr] Last revision date:180214
[St] Status:In-Process
[do] DOI:10.1691/ph.2017.6101

  8 / 1083 MEDLINE  
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[PMID]: 29316234
[Au] Autor:Ma X; Lin H; Zhang J; She Y; Zhou X; Li X; Cui Y; Wang J; Rabah T; Shao Y
[Ad] Address:College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, Gansu, China.
[Ti] Title:Extraction and identification of matrine-type alkaloids from Sophora moorcroftiana using double-templated molecularly imprinted polymers with HPLC-MS/MS.
[So] Source:J Sep Sci;, 2018 Jan 05.
[Is] ISSN:1615-9314
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Double-templated molecularly imprinted polymers with specific recognition of three matrine-type alkaloids were prepared using matrine and oxymatrine as the template molecules. An approach based on double-templated molecularly imprinted solid-phase extraction coupled with high-performance liquid chromatography and tandem mass spectrometry was then developed to extract and purify matrine, oxymatrine, and sophocarpine from Sophora moorcroftiana in the Tibetan plateau herbs. The polymers were characterized by Fourier-transform infrared spectroscopy and scanning electron microscopy. Their adsorption characteristics were evaluated using adsorption kinetics, isotherms, selectivity, and recycling experiments. This polymer exhibited excellent molecular recognition ability and good selectivity. The obtained polymers as adsorbent was further used for the determination of three matrine-type alkaloids coupled to high-performance liquid chromatography with tandem mass spectrometry, the recoveries of three matrines spiked at three concentration levels in samples were 73.25-98.42% (n = 5) with a relative standard deviation less than 6.82%. The limits of detection for the method were 9.23-15.42 µg/kg (S/N = 3). This proposed method was assessed to be an effective method for simultaneous extraction, isolation, and identification of matrine, oxymatrine, and sophocarpine from Sophora moorcroftiana.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180212
[Lr] Last revision date:180212
[St] Status:Publisher
[do] DOI:10.1002/jssc.201701133

  9 / 1083 MEDLINE  
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[PMID]: 29350757
[Au] Autor:Li W; Lu Y
[Ad] Address:School of Life Science and Biotechnology, Yangtze Normal Univ., Chongqing 408100, China.
[Ti] Title:Hepatoprotective Effects of Sophoricoside against Fructose-Induced Liver Injury via Regulating Lipid Metabolism, Oxidation, and Inflammation in Mice.
[So] Source:J Food Sci;83(2):552-558, 2018 Feb.
[Is] ISSN:1750-3841
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The dried fruit of Sophora japonica L. is a traditional Chinese herb tea rich in sophoricoside that is an isoflavone glycoside. The aim of current study was to investigate the hepatic protective effect of sophoricoside in high fructose (HF) diet fed mice. Healthy male mice were fed 30% fructose water and treated 80 and 160 mg/kg·bw sophoricoside continuously for 8 wk. Our data showed that administration of sophoricoside at 80 and 160 mg/kg·bw observably decreased the body weight and liver weight in HF-fed mice. It was found that the treatment of sophoricoside decreased the hepatic cholesterol and triglyceride levels, and serum low-density lipoprotein-cholesterol and apolipoprotein-B levels, and elevated the serum high-density lipoprotein-cholesterol and apolipoprotein-A1 levels. Moreover, the administration of sophoricoside decreased the HF-caused elevations of hepatic malonaldehyde, interleukin-1 and tumor necrosis factor-α levels, while increased the HF-induced decreases of hepatic superoxide dismutase and glutathione peroxidase activities. Meanwhile, serum aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase activities were reduced by treatment of sophoricoside in HF-fed mice. Histopathology of hematoxylin and eosin (H&E) and oil red O staining of liver tissues also confirmed the beneficial effects of sophoricoside against liver injury induced by HF-diet in mice. These findings indicated that sophoricoside may be a novel natural isoflavone for alleviating HF-induced liver injury. PRACTICAL APPLICATION: Fruit of Sophora japonica L. is a traditional herb tea and it recently becomes popular in China. Sophoricoside is an isoflavone glycoside (Genistein-4'-O-ß-d-glucopyranoside) isolated from S. japonical L, and it possessed differential effects on the body health. The ingestion of sophoricoside or sophora fruit tea may be a novel strategy to prevent non-alcoholic fatty liver disease.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180208
[Lr] Last revision date:180208
[St] Status:In-Process
[do] DOI:10.1111/1750-3841.14047

  10 / 1083 MEDLINE  
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[PMID]: 29328482
[Au] Autor:Yu L; Jiang B; Chen Z; Wang X; Shang D; Zhang X; Sun Y; Yang J; Ji Y
[Ad] Address:Center of Research and Development on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin, Heilongjiang 150076, P.R. China.
[Ti] Title:Cytisine induces endoplasmic reticulum stress caused by calcium overload in HepG2 cells.
[So] Source:Oncol Rep;39(3):1475-1484, 2018 Mar.
[Is] ISSN:1791-2431
[Cp] Country of publication:Greece
[La] Language:eng
[Ab] Abstract:Cytisine, a quinolizidine alkaloid, is one of the major bioactive components found in the small tree Sophora Alopecuraides L., and is a traditional Chinese medicine that is used for treating hepatitis and liver cancer. In the 1960s, quinolizidine alkaloids were reported to exhibit inhibitory effects on tumour cell proliferation in several types of cancer cells. However, few studies have investigated the effect of cytisine on liver cancer. Our team confirmed that cytisine induced apoptosis in HepG2 cells via a mitochondrial pathway. The primary aim of the present study was to evaluate the endoplasmic reticulum (ER) stress caused by calcium overload in cytisine­induced apoptosis in HepG2 cells and the molecular mechanisms of this phenomenon. In addition, the present study was undertaken to evaluate the expression of α7­nAChR when apoptosis was induced by cytisine in HepG2 cells. In the present study, transmission electron microscopy was used to observe the morphological appearance of HepG2 cells. The apoptosis of the cells with cytoplasmic vacuolization was significant under electron microscopy. Apoptotic bodies, the expansion of the ER, and swelling of mitochondria were observed in the HepG2 cells after cytisine treatment. Flow cytometric analysis demonstrated that the apoptosis rate of HepG2 cells was upregulated. In addition, the intracellular calcium concentration was detected by laser confocal fluorescence microscopy. The laser confocal fluorescence microscopy showed that the calcium concentration was increased in a dose­dependent manner. The activity of caspase­4 was evaluated by an enzyme­linked analyser, and the expression levels of CHOP, JNK, p­JNK and α7­nAChR were assessed via western blot analysis. In the present study, we observed that cytisine induced ER stress­inducing factors and CHOP and p­JNK1/2 protein expression, and it increased the JNK protein expression in the HepG2 cells. Furthermore, α7­nAChR protein expression was promoted in a dose­dependent manner after cytisine treatment. These findings suggest that cytisine induced the ER stress­mediated apoptotic pathway via activation of CHOP, JNK and caspase­4 in HepG2 cells, and cytisine is a potential new target compound for nAchRs (nicotinic acetylcholine receptors) to treat liver cancer.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180202
[Lr] Last revision date:180202
[St] Status:In-Process
[do] DOI:10.3892/or.2018.6200


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