Database : MEDLINE
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[PMID]: 29473522
[Au] Autor:Ebrahimi SRS; Enamzadeh E; Babaei H
[Ad] Address:Drug Applied Research Center, Department of Pharmacology and Toxicology, School of Pharmacy Tabriz University of Medical Sciences, Tabriz 51656-65811, Iran.
[Ti] Title:An Evidence-Based Review of Off-Label Uses of Polidocanol.
[So] Source:Curr Clin Pharmacol;, 2018 02 23.
[Is] ISSN:2212-3938
[Cp] Country of publication:United Arab Emirates
[La] Language:eng
[Ab] Abstract:BACKGROUND: Polidocanol is approved for its competence in treatment of varicose veins and spider veins; however, unfortunately, many of its off-label uses are still underappreciated. OBJECTIVE: Lack of an appropriate comprehensive review for off-label uses of this medication troubles physicians about making evidence-based decisions on prescribing it for its various outstanding off-label uses. This article attempts to provide physicians with the latest information concerning successful and unsuccessful use of polidocanol as an alternative treatment for esophageal and gastric varices, tendinopathy and epicondylitis, vascular malformations, varicocele, hydrocele and spermatocele, aneurysmal bone cysts, itching, management of gastrointestinal bleeding, simple renal cysts, reducing the incidence and severity of radio-induced dermatitis, and hemorrhoids. METHOD: The two databases of MEDLINE and Cochrane Library were searched for all human English studies, published in January 2006 to December 2016, which contained the keyword of "polidocanol" or its alternative MeSH terms. RESULTS: Our search identified a total number of 397 articles. Those articles that were only discussing about the approved uses of polidocanol were excluded and the remaining 117 articles were reviewed. CONCLUSION: Numerous successful administrations of this drug in a variety of clinical conditions lead to promising perspectives toward it. Sclerotherapy with polidocanol as a minimal-invasive method (having similar outcomes like the prevalent surgeries) may reduce the rate of complications. Furthermore, for determining the most appropriate method and dosage, randomized clinical trials are needed, confirming and providing more clear instructions for different conditions.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180226
[Lr] Last revision date:180226
[St] Status:Publisher
[do] DOI:10.2174/1574884713666180223121828

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[PMID]: 29240582
[Au] Autor:Paluru S; Ulbright TM; Amin M; Montironi R; Epstein JI
[Ad] Address:Department of Pathology, Johns Hopkins Medical Institute, Baltimore, MD.
[Ti] Title:The Morphologic Spectrum of Sertoliform Cystadenoma of the Rete Testis: A Series of 15 Cases.
[So] Source:Am J Surg Pathol;42(2):141-149, 2018 Feb.
[Is] ISSN:1532-0979
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Sertoliform cystadenoma of the rete testis (SCRT) is rare with only 9 cases reported to date in the literature, none with follow-up. Four large genitourinary pathology consult services were searched. We identified 15 cases of SCRT. Men were 21 to 84 years old (mean, 46 y) and had testicular discomfort or mass. Other findings were seminoma (n=1), spermatocele (n=2), hydrocele (n=1), varicocele (n=1), and scrotal hematoma (n=1). Eight had preoperative serum tumor markers, which were normal. Tumors ranged from 0.3 to 4 cm (mean, 1.5 cm). All of them were well circumscribed with solid and cystic features and occupied on average, 73% of the rete (20% to 100%). The tumors were mostly confined within dilated channels of the rete testis and showed classic features consisting of: (1) tubules with well-formed lumina in 87% of cases; (2) well-formed tubules with no lumina in 87% of cases; and (3) cords/nests in hyalinized or myxoid stroma in 73% of cases. Other patterns included: (1) solid/sheet growth in 26% of cases; (2) individual cells in 13% of cases; (3) festoons in 13% of cases; (4) branching tubules in 7% of cases; and (5) papillary in 7% of cases. Cells were cuboidal with round to oval nuclei with small nucleoli, except at the periphery where projections into rete tubules had a more columnar appearance. In the festooning pattern, nuclei were pseudostratified and columnar with prominent nucleoli and nuclear grooves. In 4 cases, tumor extended into adjacent seminiferous tubules surrounded by dense peritubular fibrosis, with in some cases small cysts lined by flattened epithelium containing pale lightly granular material. All cases lacked necrosis and significant atypia. Mitoses ranged from 0 to 2 per 10 high-power field. Follow-up ranged from 4 to 170 months with mean of 97 months. For the 13 cases with information, all patients were alive, except for 3 who died of either unrelated causes (9.2 and 10 y) or of unknown cause (4.8 y at age 89 y). We performed immunohistochemistry for steroidogenic factor 1 and inhibin in 4 of our cases, where 3 (75%) were positive for both markers. We also describe 2 additional cases which morphologically resembled SCRT but had more atypical features. This study highlights that SCRT has variable morphology. We also verify the benign nature of the lesion and its lack of association with any syndromes.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180110
[Lr] Last revision date:180110
[St] Status:In-Data-Review
[do] DOI:10.1097/PAS.0000000000000997

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[PMID]: 28902733
[Au] Autor:Albano D; Motta F; Baronchelli C; Lucchini S; Bertagna F
[Ad] Address:From the *Nuclear Medicine and †1st Department of Pathology, Spedali Civili Brescia; and ‡Nuclear Medicine, University of Brescia and Spedali Civili Brescia, Brescia, Italy.
[Ti] Title:131I Whole-Body Scan Incidental Uptake Due to Spermatocele.
[So] Source:Clin Nucl Med;42(11):901-904, 2017 Nov.
[Is] ISSN:1536-0229
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:A 46-year-old man with papillary thyroid cancer post total thyroidectomy was referred for post radioiodine (I) whole-body scan. Whole-body images revealed intense I uptake in the bed thyroid and a focal abnormal uptake in the testicular area. Subsequent SPECT/CT demonstrated that the focal uptake corresponded to the left epididymis, and the pathology report revealed a spermatocele with no immunohistochemical features for thyroid tissue. Many cases of unexpected radioiodine uptake have been reported, and spermatocele could be counted for another possibility of incidental I uptake despite an unclear mechanism.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 171009
[Lr] Last revision date:171009
[St] Status:In-Process
[do] DOI:10.1097/RLU.0000000000001838

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[PMID]: 28246564
[Au] Autor:Hannoush ZC; Palacios JD; Kuker RA; Casula S
[Ad] Address:Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
[Ti] Title:False Positive Findings on I-131 WBS and SPECT/CT in Patients with History of Thyroid Cancer: Case Series.
[So] Source:Case Rep Endocrinol;2017:8568347, 2017.
[Is] ISSN:2090-6501
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Although whole body scan (WBS) with I-131 is a highly sensitive tool for detecting normal thyroid tissue and metastasis of differentiated thyroid cancer (DTC), it is not specific. Additional information, provided by single photon emission computed tomography combined with X-ray computed tomography (SPECT/CT) and by the serum thyroglobulin level, is extremely useful for the interpretation of findings. We report four cases of false positive WBS in patients with DTC: ovarian uptake corresponding to an endometrioma, scrotal uptake due to a spermatocele, rib-cage uptake due to an old fracture, and hepatic and renal uptake secondary to a granuloma and simple cyst, respectively. Trapping, organification, and storage of iodine are more prominent in thyroid tissue but not specific. Physiologic sodium-iodine symporter expression in other tissues explains some, but not all, of the WBS false positive cases. Other proposed etiologies are accumulation of radioiodine in inflamed organs, metabolism of radiodinated thyroid hormone, presence of radioiodine in body fluids, and contamination. In our cases nonthyroidal pathologies were suspected since the imaging findings were not corroborated by an elevated thyroglobulin level, which is considered a reliable tumor marker for most well-differentiated thyroid cancers. Clinicians should be aware of the potential pitfalls of WBS in DTC to avoid incorrect management.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1703
[Cu] Class update date: 170303
[Lr] Last revision date:170303
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1155/2017/8568347

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[PMID]: 28440217
[Au] Autor:Patoulias D; Kalogirou M; Patoulias I
[Ad] Address:1st Department of Pediatric Surgery, Aristotle University of Thessaloniki, GH G. Gennimatas, Thessaloniki, Greece. dipatoulias@gmail.com.
[Ti] Title:Intraparenchymal Epididymal Cyst (IEC) 4 cm in Diameter in a 15-Year Old Male Patient; a Case Report and Review of the Literature.
[So] Source:Acta Medica (Hradec Kralove);59(4):137-139, 2016.
[Is] ISSN:1211-4286
[Cp] Country of publication:Czech Republic
[La] Language:eng
[Ab] Abstract:Intraparenchymal epididymal cysts (IECs) are benign cystic formations of the epididymis of unknown pathogenesis, which typically appear in adolescence or adulthood. In patients older than 14 years old their prevalence is doubled. After systematic and thorough research of the current literature, we did not find another case report of intraparenchymal epididymal cyst with similar dimensions. The male patient, 15 years old, visited our outpatient department complaining of pain in the right hemiscrotum. Diagnosis of IEC was confirmed after the conduction of ultrasound examination. Patient underwent surgical exploration of the right hemiscrotum. Resection of the IEC followed. Postoperative course was uneventful, with recession of the symptoms. In our opinion, IECs should be surgically removed, either when they are symptomatic or when they are asymptomatic, but of a diameter greater than 1 cm and without regression tendency.
[Mh] MeSH terms primary: Spermatocele/pathology
[Mh] MeSH terms secundary: Adolescent
Humans
Male
Spermatocele/surgery
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Entry month:1706
[Cu] Class update date: 170606
[Lr] Last revision date:170606
[Js] Journal subset:IM
[Da] Date of entry for processing:170426
[St] Status:MEDLINE
[do] DOI:10.14712/18059694.2017.41

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[PMID]: 28058232
[Au] Autor:Ameli M; Parsapour A; Gholami-Mahtaj L
[Ad] Address:Department of Urology, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.
[Ti] Title:A 40-year-old man with testicular torsion and large bilateral spermatoceles.
[So] Source:Qatar Med J;2016(2):10, 2016.
[Is] ISSN:0253-8253
[Cp] Country of publication:Qatar
[La] Language:eng
[Ab] Abstract:Testicular torsion is a rare disease that mostly involves children. Peak incidence is in infancy and in adolescence. Testicular torsion is rarely seen in men over 40 years of age and has only once been accompanied with spermatocele. We report the case of a 40-year-old man with testicular pain one day prior to visiting our clinic. The patient's visit to the clinic was delayed due to history of occasional testicular pain related to his bilateral spermatoceles. On arrival, a color Doppler ultrasound test was performed, which revealed heterogeneous echo in the right testis with no vascular flow, suggestive of torsion, as well as two cystic lesions in the right and left scrotums indicating spermatoceles. The patient was immediately transferred to the operating room where the bilateral spermatoceles were resected and after detorting, the right testis was saved. After four months, a normal left testis along with partial right testicular atrophy was observed. It is highly recommended to educate patients with spermatocele who have no indication for surgical treatment to visit their physician in case any new testicular pain is experienced. Furthermore, testicular pain regardless of the co-existing pathology may always be treated as an indicator of suspected torsion.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1701
[Cu] Class update date: 170816
[Lr] Last revision date:170816
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.5339/qmj.2016.10

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[PMID]: 27483085
[Au] Autor:Matulewicz RS; Meeks JJ
[Ti] Title:JAMA PATIENT PAGE. Testicular Mass.
[So] Source:JAMA;316(5):557, 2016 Aug 02.
[Is] ISSN:1538-3598
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Testicular Diseases/diagnosis
Testicular Diseases/therapy
Testis/pathology
[Mh] MeSH terms secundary: Humans
Male
Neoplasm Staging
Orchiectomy
Spermatocele/diagnosis
Spermatocele/therapy
Testicular Diseases/pathology
Testicular Hydrocele/diagnosis
Testicular Hydrocele/therapy
Testicular Neoplasms/diagnosis
Testicular Neoplasms/therapy
Testis/blood supply
Varicocele/diagnosis
Varicocele/therapy
[Pt] Publication type:JOURNAL ARTICLE; PATIENT EDUCATION HANDOUT
[Em] Entry month:1608
[Cu] Class update date: 161017
[Lr] Last revision date:161017
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:160803
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2016.2445

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[PMID]: 27454594
[Au] Autor:Papadakis GZ; Millo C; Sadowski SM; Bagci U; Patronas NJ
[Ad] Address:From the *Radiology and Imaging Sciences, Warren Grant Magnuson Clinical Center, †Division of Nuclear Medicine, RADIS, Clinical Center, and ‡Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD; §Endocrine and Thoracic Surgery, University Hospitals of Geneva, Geneva, Switzerland; and ∥Center for Research in Computer Vision, Electrical and Computer Science Department, University of Central Florida, Orlando, FL.
[Ti] Title:Epididymal Cystadenomas in von Hippel-Lindau Disease Showing Increased Activity on 68Ga DOTATATE PET/CT.
[So] Source:Clin Nucl Med;41(10):781-2, 2016 Oct.
[Is] ISSN:1536-0229
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:von Hippel-Lindau (VHL) disease is a familial cancer syndrome characterized by the development of a variety of malignant and benign tumors, including epididymal cystadenomas. We report a case of a VHL patient with bilateral epididymal cystadenomas who was evaluated with Ga DOTATATE PET/CT, showing intensely increased activity (SUVmax, 21.6) associated with the epididymal cystadenomas, indicating cell-surface overexpression of somatostatin receptors. The presented case supports the usefulness of somatostatin receptor imaging using Ga DOTA-conjugated peptides for detection and follow-up of VHL manifestations, as well as surveillance of asymptomatic gene carriers.
[Mh] MeSH terms primary: Cystadenoma/diagnostic imaging
Positron Emission Tomography Computed Tomography
Spermatocele/diagnostic imaging
von Hippel-Lindau Disease/diagnostic imaging
[Mh] MeSH terms secundary: Humans
Male
Middle Aged
Organometallic Compounds
Radiopharmaceuticals
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Organometallic Compounds); 0 (Radiopharmaceuticals); 9L17Y0H71P (dotatate gallium ga-68)
[Em] Entry month:1701
[Cu] Class update date: 171031
[Lr] Last revision date:171031
[Js] Journal subset:IM
[Da] Date of entry for processing:160726
[St] Status:MEDLINE
[do] DOI:10.1097/RLU.0000000000001314

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[PMID]: 27421073
[Au] Autor:Hicks N; Gupta S
[Ad] Address:a Worcestershire Acute Hospitals NHS Trust , Worcester , UK.
[Ti] Title:Complications and risk factors in elective benign scrotal surgery.
[So] Source:Scand J Urol;50(6):468-471, 2016 Dec.
[Is] ISSN:2168-1813
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: The primary aim of this study was to assess the complication rate after elective scrotal surgery for benign conditions, following the observation that a higher than expected number of patients were requiring intervention for complications of their surgery. The secondary aim was to assess how different risk factors affected the complication rate, therefore identifying areas for improvement in clinical practice. MATERIALS AND METHODS: All patients from April 2008 to September 2013 who underwent an elective hydrocele repair, epididymal cyst excision or epididymectomy at a UK district general hospital were included. Patient notes were reviewed and risk factors for surgery and postoperative complications recorded. RESULTS: In total, 222 patients were included. The overall complication rate was 27.4%. Complications included haematoma (9.0%), infection (5.0%), recurrence of swelling (7.2%) and chronic pain (0.2%). The only risk factor to have a significant relationship to complication rate was a body mass index of 30 kg/m² or greater (χ² = 6.698, p = 0.010). CONCLUSIONS: The most common complications after scrotal surgery for benign conditions were haematoma formation, infection and recurrence or persistence of swelling. The only risk factor identified as having a potentially adverse effect on complication rate was a raised body mass index of 30 or greater.
[Mh] MeSH terms primary: Body Mass Index
Edema/etiology
Hematoma/etiology
Postoperative Complications/etiology
Urogenital Surgical Procedures/adverse effects
[Mh] MeSH terms secundary: Adolescent
Adult
Aged
Aged, 80 and over
Chronic Pain/etiology
Elective Surgical Procedures/adverse effects
Epididymis/surgery
Humans
Infection/etiology
Male
Middle Aged
Recurrence
Risk Factors
Spermatocele/surgery
Testicular Hydrocele/surgery
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1706
[Cu] Class update date: 170620
[Lr] Last revision date:170620
[Js] Journal subset:IM
[Da] Date of entry for processing:160716
[St] Status:MEDLINE

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[PMID]: 27352614
[Au] Autor:Dyer C
[Ad] Address:The BMJ.
[Ti] Title:Surgeon who removed patient's testicle is struck off.
[So] Source:BMJ;353:i3587, 2016 Jun 27.
[Is] ISSN:1756-1833
[Cp] Country of publication:England
[La] Language:eng
[Mh] MeSH terms primary: Licensure
Medical Errors
Orchiectomy
Spermatocele/surgery
[Mh] MeSH terms secundary: Deception
Humans
Male
[Pt] Publication type:NEWS
[Em] Entry month:1702
[Cu] Class update date: 170817
[Lr] Last revision date:170817
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:160630
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.i3587


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