Database : MEDLINE
Search on : Spinal and Cord and Neoplasms [Words]
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[PMID]: 29506496
[Au] Autor:Yon DK; Ahn TK; Shin DE; Kim GI; Kim MK
[Ad] Address:Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea.
[Ti] Title:Extragonadal germ cell tumor of the posterior mediastinum in a child complicated with spinal cord compression: a case report.
[So] Source:BMC Pediatr;18(1):97, 2018 Mar 05.
[Is] ISSN:1471-2431
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Germ cell tumors (GCTs) in children are rare neoplasms with diverse pathological findings according to the site and age of presentation. The most common symptoms in children with mediastinal GCTs, which are nonspecific, are dyspnea, chest pain, cough, hemoptysis, vena cava occlusion syndrome, and fatigue/weakness. Because of these nonspecific symptoms, it is difficult to suspect a mediastinal mass. A posterior mediastinal tumor causing spinal cord compression is an important example of an oncologic emergency arising from a neurogenic tumor. CASE PRESENTATION: Children with posterior mediastinum GCTs can be easily mistaken as having a neurogenic tumor because of site of tumor origin. We treated our 7-year-old patient with emergency decompression surgery and high-dose steroid pulse therapy to prevent secondary injury to the spinal cord. Primary injury was a result of spinal cord compression due to the initial manifestation of GCT in the posterior mediastinum. Cisplatin-based chemotherapy was also administered. The patient was followed up regularly for 3 years and is undergoing rehabilitation without any signs of recurrence. CONCLUSIONS: We present an extremely rare case of a child with paraparesis caused by extradural spinal cord compression as the initial manifestation of GCT in the posterior mediastinum. The child was treated with emergency decompression surgery and high-dose pulse steroid therapy to prevent secondary injury to the spinal cord.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Data-Review
[do] DOI:10.1186/s12887-018-1070-6

  2 / 18235 MEDLINE  
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[PMID]: 29351303
[Au] Autor:Mihaylov IB; Mellon EA; Yechieli R; Portelance L
[Ad] Address:Department of Radiation Oncology, University of Miami,Miami, FL, United States of America.
[Ti] Title:Automated inverse optimization facilitates lower doses to normal tissue in pancreatic stereotactic body radiotherapy.
[So] Source:PLoS One;13(1):e0191036, 2018.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: Inverse planning is trial-and-error iterative process. This work introduces a fully automated inverse optimization approach, where the treatment plan is closely tailored to the unique patient anatomy. The auto-optimization is applied to pancreatic stereotactic body radiotherapy (SBRT). MATERIALS AND METHODS: The automation is based on stepwise reduction of dose-volume histograms (DVHs). Five uniformly spaced points, from 1% to 70% of the organ at risk (OAR) volumes, are used. Doses to those DVH points are iteratively decreased through multiple optimization runs. With each optimization run the doses to the OARs are decreased, while the dose homogeneity over the target is increased. The iterative process is terminated when a pre-specified dose heterogeneity over the target is reached. Twelve pancreatic cases were retrospectively studied. Doses to the target, maximum doses to duodenum, bowel, stomach, and spinal cord were evaluated. In addition, mean doses to liver and kidneys were tallied. The auto-optimized plans were compared to the actual treatment plans, which are based on national protocols. RESULTS: The prescription dose to 95% of the planning target volume (PTV) is the same for the treatment and the auto-optimized plans. The average difference for maximum doses to duodenum, bowel, stomach, and spinal cord are -4.6 Gy, -1.8 Gy, -1.6 Gy, and -2.4 Gy respectively. The negative sign indicates lower doses with the auto-optimization. The average differences in the mean doses to liver and kidneys are -0.6 Gy, and -1.1 Gy to -1.5 Gy respectively. CONCLUSIONS: Automated inverse optimization holds great potential for personalization and tailoring of radiotherapy to particular patient anatomies. It can be utilized for normal tissue sparing or for an isotoxic dose escalation.
[Mh] MeSH terms primary: Automation
Radiotherapy Dosage
[Mh] MeSH terms secundary: Humans
Pancreas/radiation effects
Pancreatic Neoplasms/radiotherapy
Retrospective Studies
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:180120
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191036

  3 / 18235 MEDLINE  
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[PMID]: 29521579
[Au] Autor:Wostrack M; Ringel F; Eicker SO; Jägersberg M; Schaller K; Kerschbaumer J; Thomé C; Shiban E; Stoffel M; Friedrich B; Kehl V; Vajkoczy P; Meyer B; Onken J
[Ad] Address:Department of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich.
[Ti] Title:Spinal ependymoma in adults: a multicenter investigation of surgical outcome and progression-free survival.
[So] Source:J Neurosurg Spine;:1-9, 2018 Mar 09.
[Is] ISSN:1547-5646
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE Spinal ependymomas are rare glial neoplasms. Because their incidence is low, only a few larger studies have investigated this condition. There are no clear data concerning prognosis and therapy. The aim of the study was to describe the natural history, perioperative clinical course, and local tumor control of adult patients with spinal ependymomas who were surgically treated under modern treatment standards. METHODS The authors performed a multicenter retrospective study. They identified 158 adult patients with spinal ependymomas who had received surgical treatment between January 2006 and June 2013. The authors analyzed the clinical and histological aspects of these cases to identify the predictive factors for postoperative morbidity, tumor resectability, and recurrence. RESULTS Gross-total resection (GTR) was achieved in 80% of cases. At discharge, 37% of the patients showed a neurological decline. During follow-up the majority recovered, whereas 76% showed at least preoperative status. Permanent functional deterioration remained in 2% of the patients. Transient deficits were more frequent in patients with cervically located ependymomas (p = 0.004) and in older patients (p = 0.002). Permanent deficits were independently predicted only by older age (p = 0.026). Tumor progression was observed in 15 cases. The 5-year progression-free survival (PFS) rate was 80%, and GTR (p = 0.037), WHO grade II (p = 0.009), and low Ki-67 index (p = 0.005) were independent prognostic factors for PFS. Adjuvant radiation therapy was performed in 15 cases. No statistically relevant effects of radiation therapy were observed among patients with incompletely resected ependymomas (p = 0.079). CONCLUSIONS Due to its beneficial value for PFS, GTR is important in the treatment of spinal ependymoma. Gross-total resection is feasible in the majority of cases, with acceptable rates of permanent deficits. Also, Ki-67 appears to be an important prognostic factor and should be included in a grading scheme for spinal ependymomas.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.3171/2017.9.SPINE17494

  4 / 18235 MEDLINE  
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[PMID]: 29382830
[Au] Autor:Aramillo Irizar P; Schäuble S; Esser D; Groth M; Frahm C; Priebe S; Baumgart M; Hartmann N; Marthandan S; Menzel U; Müller J; Schmidt S; Ast V; Caliebe A; König R; Krawczak M; Ristow M; Schuster S; Cellerino A; Diekmann S; Englert C; Hemmerich P; Sühnel J; Guthke R; Witte OW; Platzer M; Ruppin E; Kaleta C
[Ad] Address:Research Group Medical Systems Biology, Institute of Experimental Medicine, Christian-Albrechts-University Kiel, D-24105, Kiel, Germany.
[Ti] Title:Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly.
[So] Source:Nat Commun;9(1):327, 2018 01 30.
[Is] ISSN:2041-1723
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Disease epidemiology during ageing shows a transition from cancer to degenerative chronic disorders as dominant contributors to mortality in the old. Nevertheless, it has remained unclear to what extent molecular signatures of ageing reflect this phenomenon. Here we report on the identification of a conserved transcriptomic signature of ageing based on gene expression data from four vertebrate species across four tissues. We find that ageing-associated transcriptomic changes follow trajectories similar to the transcriptional alterations observed in degenerative ageing diseases but are in opposite direction to the transcriptomic alterations observed in cancer. We confirm the existence of a similar antagonism on the genomic level, where a majority of shared risk alleles which increase the risk of cancer decrease the risk of chronic degenerative disorders and vice versa. These results reveal a fundamental trade-off between cancer and degenerative ageing diseases that sheds light on the pronounced shift in their epidemiology during ageing.
[Mh] MeSH terms primary: Aging/genetics
Cardiovascular Diseases/genetics
Diabetes Mellitus/genetics
Neoplasms/genetics
Neurodegenerative Diseases/genetics
Transcriptome
[Mh] MeSH terms secundary: Adolescent
Adult
Aged
Aged, 80 and over
Aging/metabolism
Aging/pathology
Animals
Brain/growth & development
Brain/metabolism
Cardiovascular Diseases/blood
Cardiovascular Diseases/pathology
Child
Child, Preschool
Chronic Disease
Diabetes Mellitus/blood
Diabetes Mellitus/pathology
Fundulidae/genetics
Fundulidae/growth & development
Fundulidae/metabolism
Gene Ontology
Genome, Human
Humans
Infant
Liver/growth & development
Liver/metabolism
Mice
Middle Aged
Molecular Sequence Annotation
Neoplasms/metabolism
Neoplasms/pathology
Neurodegenerative Diseases/blood
Neurodegenerative Diseases/pathology
Skin/growth & development
Skin/metabolism
Zebrafish/genetics
Zebrafish/growth & development
Zebrafish/metabolism
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[Js] Journal subset:IM
[Da] Date of entry for processing:180201
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02395-2

  5 / 18235 MEDLINE  
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[PMID]: 29306837
[Au] Autor:Saraswati AP; Ali Hussaini SM; Krishna NH; Babu BN; Kamal A
[Ad] Address:Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500 037, India.
[Ti] Title:Glycogen synthase kinase-3 and its inhibitors: Potential target for various therapeutic conditions.
[So] Source:Eur J Med Chem;144:843-858, 2018 Jan 20.
[Is] ISSN:1768-3254
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:Glycogen Synthase Kinase-3 (GSK-3) is a serine/threonine kinase which is ubiquitously expressed and is regarded as a regulator for various cellular events and signalling pathways. It exists in two isoforms, GSK-3α and GSK-3ß and can phosphorylate a wide range of substrates. Aberrancy in the GSK-3 activity can lead to various diseases like Alzheimer's, diabetes, cancer, neurodegeneration etc., rendering it an attractive target to develop potent and specific inhibitors. The present review focuses on the recent developments in the area of GSK-3 inhibitors and also enlightens its therapeutic applicability in various disease conditions.
[Mh] MeSH terms primary: Antineoplastic Agents/pharmacology
Glycogen Synthase Kinase 3/antagonists & inhibitors
Hypoglycemic Agents/pharmacology
Neoplasms/drug therapy
Neuroprotective Agents/pharmacology
Protein Kinase Inhibitors/pharmacology
[Mh] MeSH terms secundary: Alzheimer Disease/drug therapy
Alzheimer Disease/metabolism
Antineoplastic Agents/chemistry
Diabetes Mellitus/drug therapy
Diabetes Mellitus/metabolism
Glycogen Synthase Kinase 3/metabolism
Humans
Hypoglycemic Agents/chemistry
Neoplasms/metabolism
Neurodegenerative Diseases/drug therapy
Neurodegenerative Diseases/metabolism
Neuroprotective Agents/chemistry
Protein Kinase Inhibitors/chemistry
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Antineoplastic Agents); 0 (Hypoglycemic Agents); 0 (Neuroprotective Agents); 0 (Protein Kinase Inhibitors); EC 2.7.11.26 (Glycogen Synthase Kinase 3)
[Em] Entry month:1803
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[Js] Journal subset:IM
[Da] Date of entry for processing:180108
[St] Status:MEDLINE

  6 / 18235 MEDLINE  
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[PMID]: 27774897
[Au] Autor:Li J; Gao Y; Ren X; Li Y; Wu L; Yang X; Wang J; Shang H; Xiong X; Xing Y
[Ad] Address:Department of Cardiology, Guang`anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China.
[Ti] Title:The Role of Biologically Active Ingredients from Chinese Herbal Medicines in the Regulation of Autophagy in Treating Cardiovascular Diseases and Other Chronic Diseases.
[So] Source:Curr Pharm Des;23(7):1060-1069, 2017.
[Is] ISSN:1873-4286
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Autophagy, a highly conserved starvation response mechanism with both defensive and protective effects in eukaryotic cells, is a lysosome-mediated degradation process for non-essential or damaged cellular constituents. It plays an important role in the cell survival, differentiation and development to maintain homeostasis. Autophagy is involved in cardiovascular diseases, cerebrovascular diseases, and neurodegenerative diseases, as well as tumours. Thus, modulating autophagy may provide potential therapeutic strategies. Recently, many active components of Chinese herbal medicines (CHM) have been found to modulate autophagy in myocardial cells, cerebral vascular cells, endothelial cells and tumour cells. This paper reviews the advances in studies on the active components of CHM that modulating autophagy in treating cardiovascular diseases and other chronic diseases over the past five years.
[Mh] MeSH terms primary: Autophagy/drug effects
Cardiovascular Diseases/drug therapy
Cerebrovascular Disorders/drug therapy
Drugs, Chinese Herbal/pharmacology
Neoplasms/drug therapy
Neurodegenerative Diseases/drug therapy
[Mh] MeSH terms secundary: Cardiovascular Diseases/pathology
Cerebrovascular Disorders/pathology
Chronic Disease/drug therapy
Drugs, Chinese Herbal/chemistry
Drugs, Chinese Herbal/isolation & purification
Humans
Neoplasms/pathology
Neurodegenerative Diseases/pathology
[Pt] Publication type:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Drugs, Chinese Herbal)
[Em] Entry month:1802
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[Js] Journal subset:IM
[Da] Date of entry for processing:161025
[St] Status:MEDLINE
[do] DOI:10.2174/1381612822666161021161850

  7 / 18235 MEDLINE  
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[PMID]: 29254323
[Au] Autor:Ciappetta P; Taurone S; Spoletini M; Artico M
[Ad] Address:Department of Basic Medical Sciences, Neuroscience and Sensory Organs, University of Bari.
[Ti] Title:Anteriorly placed tumors to the conus: removal by interradicular window.
[So] Source:J Biol Regul Homeost Agents;31(4):1115-1118, 2017 Oct-Dec.
[Is] ISSN:0393-974X
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:Tumors anteriorly situated to the medullary conus are rarely encountered and represent a true surgical challenge. We examined the literature on this topic, concluding that there are no previous reports on alternative surgical techniques different to the traditional one. We report two cases of intradural extramedullary tumor operated on by a technique performed through a window opened between the spinal roots, which allows an easy, effective and useful resection. We describe a new operative technique which ensures a complete removal of these tumors and discuss clinical implications in the light of the available literature on this topic.
[Mh] MeSH terms primary: Meningioma/surgery
Neurosurgical Procedures/methods
Recovery of Function/physiology
Spinal Cord Neoplasms/surgery
Spinal Cord/surgery
[Mh] MeSH terms secundary: Adult
Female
Humans
Magnetic Resonance Imaging
Meningioma/diagnostic imaging
Meningioma/pathology
Middle Aged
Spinal Cord/diagnostic imaging
Spinal Cord/pathology
Spinal Cord Neoplasms/diagnostic imaging
Spinal Cord Neoplasms/pathology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[Js] Journal subset:IM
[Da] Date of entry for processing:171220
[St] Status:MEDLINE

  8 / 18235 MEDLINE  
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[PMID]: 29390509
[Au] Autor:Kong P; Yan J; Liu D; Ji Y; Wang Y; Zhuang J; Wang J; Hu X; Yue X
[Ad] Address:The Second Affiliated Hospital of Harbin Medical University.
[Ti] Title:Skeletal-related events and overall survival of patients with bone metastasis from nonsmall cell lung cancer - A retrospective analysis.
[So] Source:Medicine (Baltimore);96(51):e9327, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Because of improving treatments and survival, 40% to 58% of patients with bone metastases from nonsmall cell lung cancer (NSCLC) will suffer from at least one skeletal-related event (SRE), affecting their quality of life, but the natural history of SRE is poorly understood. The study aimed to examine the factors involved in SRE-free survival (SRS) and overall survival (OS) of patients with NSCLC and bone metastases.This was a retrospective study of 211 patients with bone metastasis from NSCLC and treated at the Tumor Hospital Affiliated to Harbin Medical University between January 2007 and January 2012. OS and SRS were evaluated by the Kaplan-Meier method. The factors associated with SRS and OS were examined using multivariate Cox analyses.The 1 year OS was 55.9% and the median OS was 30 months (range, 1-98 months). Multivariate analyses showed that clinical staging at initial diagnosis (P < .001) and SRE (P = .033) were independently associated with OS, and clinical staging at initial diagnosis (P = .009), bone pain (P = .008), primary tumor radiotherapy (P < .001), and chemotherapy (P = .031) were independently associated with SRS. Stage I, II, and III patients under biphosphonate therapy fared better than those without biphosphonate treatment, but there was no difference for stage IV patients.The identification of factors associated with OS and SRS of patients with NSCLC and bone metastases should provide new clues for a better management of these patients.
[Mh] MeSH terms primary: Bone Neoplasms/mortality
Carcinoma, Non-Small-Cell Lung/mortality
Fractures, Spontaneous/epidemiology
Hypercalcemia/epidemiology
Lung Neoplasms/mortality
Spinal Cord Compression/epidemiology
[Mh] MeSH terms secundary: Adult
Aged
Aged, 80 and over
Bone Neoplasms/secondary
Carcinoma, Non-Small-Cell Lung/pathology
Carcinoma, Non-Small-Cell Lung/secondary
Carcinoma, Non-Small-Cell Lung/therapy
China/epidemiology
Female
Humans
Lung Neoplasms/pathology
Lung Neoplasms/therapy
Male
Middle Aged
Multivariate Analysis
Retrospective Studies
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180220
[Lr] Last revision date:180220
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009327

  9 / 18235 MEDLINE  
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[PMID]: 28462702
[Au] Autor:Cau Y; Valensin D; Mori M; Draghi S; Botta M
[Ad] Address:Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, Siena. Italy.
[Ti] Title:Structure, Function, Involvement in Diseases and Targeting of 14-3-3 Proteins: An Update.
[So] Source:Curr Med Chem;25(1):5-21, 2018.
[Is] ISSN:1875-533X
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:14-3-3 is a class of proteins able to interact with a multitude of targets by establishing protein-protein interactions (PPIs). They are usually found in all eukaryotes with a conserved secondary structure and high sequence homology among species. 14-3-3 proteins are involved in many physiological and pathological cellular processes either by triggering or interfering with the activity of specific protein partners. In the last years, the scientific community has collected many evidences on the role played by seven human 14-3-3 isoforms in cancer or neurodegenerative diseases. Indeed, these proteins regulate the molecular mechanisms associated to these diseases by interacting with (i) oncogenic and (ii) pro-apoptotic proteins and (iii) with proteins involved in Parkinson and Alzheimer diseases. The discovery of small molecule modulators of 14-3-3 PPIs could facilitate complete understanding of the physiological role of these proteins, and might offer valuable therapeutic approaches for these critical pathological states.
[Mh] MeSH terms primary: 14-3-3 Proteins/antagonists & inhibitors
Neoplasms/drug therapy
Neurodegenerative Diseases/drug therapy
Small Molecule Libraries/pharmacology
[Mh] MeSH terms secundary: 14-3-3 Proteins/chemistry
14-3-3 Proteins/metabolism
Humans
Protein Binding/drug effects
Small Molecule Libraries/chemistry
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (14-3-3 Proteins); 0 (Small Molecule Libraries)
[Em] Entry month:1802
[Cu] Class update date: 180220
[Lr] Last revision date:180220
[Js] Journal subset:IM
[Da] Date of entry for processing:170503
[St] Status:MEDLINE
[do] DOI:10.2174/0929867324666170426095015

  10 / 18235 MEDLINE  
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[PMID]: 29252657
[Au] Autor:Kojima K; Iwanami A; Mikami S; Ishii K; Matsumoto M; Nakamura M
[Ad] Address:Departments of Orthopedic Surgery (K.K., A.I., K.I., M.M., and M.N.) and Pathology (S.M.), Keio University School of Medicine, Tokyo, Japan.
[Ti] Title:An Intramedullary Osteolipoma of the Upper Thoracic Spinal Cord: A Case Report.
[So] Source:JBJS Case Connect;6(3):e80, 2016 Jul-Sep.
[Is] ISSN:2160-3251
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:CASE: We present a rare case of an intramedullary osteolipoma without any extramedullary connections or coexisting spinal dysraphism. A 48-year-old woman presented with back pain and pain around the lateral aspect of the left thigh. Magnetic resonance imaging (MRI) revealed a heterogeneous hyperintense and hypointense region on T1 and T2-weighted imaging. A cavernous hemangioma was suspected, and the patient was admitted for surgical resection. The histological diagnosis was an intramedullary osteolipoma. CONCLUSION: MRI with fat suppression and computed tomography are recommended for the diagnosis of an intramedullary osteolipoma, but a definitive diagnosis requires histological examination.
[Mh] MeSH terms primary: Lipoma/diagnosis
Spinal Cord Neoplasms/diagnosis
[Mh] MeSH terms secundary: Female
Humans
Lipoma/pathology
Middle Aged
Spinal Cord Neoplasms/pathology
Thoracic Vertebrae/pathology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[Js] Journal subset:IM
[Da] Date of entry for processing:171219
[St] Status:MEDLINE
[do] DOI:10.2106/JBJS.CC.16.00025


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