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[PMID]: 28747424
[Au] Autor:Schwartz C; Khan AR; Floudas A; Saunders SP; Hams E; Rodewald HR; McKenzie ANJ; Fallon PG
[Ad] Address:Trinity Biomedical Sciences Institute, School of Medicine, Trinity College Dublin, Dublin, Ireland.
[Ti] Title:ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control.
[So] Source:J Exp Med;214(9):2507-2521, 2017 Sep 04.
[Is] ISSN:1540-9538
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Group 2 innate lymphoid cells (ILC2s) are important effector cells driving the initiation of type 2 immune responses leading to adaptive T helper 2 (Th2) immunity. Here we show that ILC2s dynamically express the checkpoint inhibitor molecule PD-L1 during type 2 pulmonary responses. Surprisingly, PD-L1:PD-1 interaction between ILC2s and CD4 T cells did not inhibit the T cell response, but PD-L1-expressing ILC2s stimulated increased expression of GATA3 and production of IL-13 by Th2 cells both in vitro and in vivo. Conditional deletion of PD-L1 on ILC2s impaired early Th2 polarization and cytokine production, leading to delayed worm expulsion during infection with the gastrointestinal helminth Our results identify a novel PD-L1-controlled mechanism for type 2 polarization, with ILC2s mediating an innate checkpoint to control adaptive T helper responses, which has important implications for the treatment of type 2 inflammation.
[Mh] MeSH terms primary: B7-H1 Antigen/physiology
Lymphocytes/physiology
Th2 Cells/physiology
[Mh] MeSH terms secundary: Adaptive Immunity/immunology
Adaptive Immunity/physiology
Animals
B7-H1 Antigen/immunology
GATA3 Transcription Factor/physiology
Immunity, Cellular/immunology
Immunity, Cellular/physiology
Interleukin-13/physiology
Lymphocytes/immunology
Mice
Mice, Inbred C57BL
Nippostrongylus/immunology
Strongylida Infections/immunology
Th2 Cells/immunology
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (B7-H1 Antigen); 0 (Cd274 protein, mouse); 0 (GATA3 Transcription Factor); 0 (Gata3 protein, mouse); 0 (Interleukin-13)
[Em] Entry month:1709
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:IM
[Da] Date of entry for processing:170728
[St] Status:MEDLINE
[do] DOI:10.1084/jem.20170051

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[PMID]: 29258532
[Au] Autor:Grandi G; Lind EO; Schaper R; Ågren E; Schnyder M
[Ad] Address:Department of Microbiology, National Veterinary Institute, Ulls väg 2B, SE-756 51, Uppsala, Sweden. giulio.grandi@slu.se.
[Ti] Title:Canine angiostrongylosis in Sweden: a nationwide seroepidemiological survey by enzyme-linked immunosorbent assays and a summary of five-year diagnostic activity (2011-2015).
[So] Source:Acta Vet Scand;59(1):85, 2017 Dec 19.
[Is] ISSN:1751-0147
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: For the first time in Sweden, Angiostrongylus vasorum was detected on the island of Sydkoster in foxes and dogs in 2003. After sporadic detection of the parasite in foxes in southern Sweden, the first positive canine faecal sample on the mainland was found in 2011. Since then a total of 2882 faecal samples have been analysed with the Baermann test at the National Veterinary Institute (SVA) during the years 2011-2015; 20 of them being positive. Contemporaneously, of over 525 fox necropsies, only three were found to be infected. To gather a more accurate knowledge of A. vasorum occurrence in Sweden, a large scale seroepidemiological survey was performed and totally 3885 serum samples from dogs were tested for both the presence of circulating antigens and of specific antibodies to A. vasorum. RESULTS: In total, 0.10% (n = 4, 95% Confidence Intervals, CI 0.03-0.26%) of the dogs were positive for both antigen and antibodies, whereas 0.51% (n = 20, CI 0.31-0.79%) of the tested dogs were only antigen positive and 0.88% (n = 34, CI 0.61-1.22%) only positive for specific antibodies. Seropositive animals, as well as the majority of A. vasorum-positive faecal samples tested during the same period, were spread over central and southern Sweden. Annual prevalence of positive faecal dog samples and of necropsied A. vasorum positive foxes (coming from southern Sweden) varied from 0.3 to 0.9% (overall: 0.7%, CI 0.4-1.1%) and 0.0 to 1.4% (overall: 0.3%, CI 0.1-0.9%), respectively. CONCLUSIONS: The findings confirmed that A. vasorum has become established in various geographical areas of central and southern Sweden. Veterinarians and dog owners should be aware of the potential risks of infection in large areas of the country, since canine angiostrongylosis may be a fatal disease if left untreated.
[Mh] MeSH terms primary: Dog Diseases/epidemiology
Enzyme-Linked Immunosorbent Assay/veterinary
Strongylida Infections/veterinary
[Mh] MeSH terms secundary: Angiostrongylus
Animals
Dog Diseases/parasitology
Dogs
Feces/parasitology
Foxes/parasitology
Seroepidemiologic Studies
Strongylida Infections/epidemiology
Sweden
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180202
[Lr] Last revision date:180202
[Js] Journal subset:IM
[Da] Date of entry for processing:171221
[St] Status:MEDLINE
[do] DOI:10.1186/s13028-017-0351-7

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[PMID]: 29252992
[Au] Autor:Jarvi SI; Quarta S; Jacquier S; Howe K; Bicakci D; Dasalla C; Lovesy N; Snook K; McHugh R; Niebuhr CN
[Ad] Address:Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, Hawaii, United States of America.
[Ti] Title:High prevalence of Angiostrongylus cantonensis (rat lungworm) on eastern Hawai'i Island: A closer look at life cycle traits and patterns of infection in wild rats (Rattus spp.).
[So] Source:PLoS One;12(12):e0189458, 2017.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The nematode Angiostrongylus cantonensis is a zoonotic pathogen and the etiological agent of human angiostrongyliasis or rat lungworm disease. Hawai'i, particularly east Hawai'i Island, is the epicenter for angiostrongyliasis in the USA. Rats (Rattus spp.) are the definitive hosts while gastropods are intermediate hosts. The main objective of this study was to collect adult A. cantonensis from wild rats to isolate protein for the development of a blood-based diagnostic, in the process we evaluated the prevalence of infection in wild rats. A total of 545 wild rats were sampled from multiple sites in the South Hilo District of east Hawai'i Island. Adult male and female A. cantonensis (3,148) were collected from the hearts and lungs of humanely euthanized Rattus rattus, and R. exulans. Photomicrography and documentation of multiple stages of this parasitic nematode in situ were recorded. A total of 45.5% (197/433) of rats inspected had lung lobe(s) (mostly upper right) which appeared granular indicating this lobe may serve as a filter for worm passage to the rest of the lung. Across Rattus spp., 72.7% (396/545) were infected with adult worms, but 93.9% (512/545) of the rats were positive for A. cantonensis infection based on presence of live adult worms, encysted adult worms, L3 larvae and/or by PCR analysis of brain tissue. In R. rattus we observed an inverse correlation with increased body mass and infection level of adult worms, and a direct correlation between body mass and encysted adult worms in the lung tissue, indicating that larger (older) rats may have developed a means of clearing infections or regulating the worm burden upon reinfection. The exceptionally high prevalence of A. cantonensis infection in Rattus spp. in east Hawai'i Island is cause for concern and indicates the potential for human infection with this emerging zoonosis is greater than previously thought.
[Mh] MeSH terms primary: Angiostrongylus cantonensis/physiology
Rats/parasitology
Strongylida Infections/veterinary
[Mh] MeSH terms secundary: Animals
Female
Geography
Hawaii/epidemiology
Islands
Life Cycle Stages
Linear Models
Male
Prevalence
Pulmonary Artery/parasitology
Strongylida Infections/epidemiology
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180108
[Lr] Last revision date:180108
[Js] Journal subset:IM
[Da] Date of entry for processing:171219
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189458

  4 / 2136 MEDLINE  
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[PMID]: 29045903
[Au] Autor:Osbourn M; Soares DC; Vacca F; Cohen ES; Scott IC; Gregory WF; Smyth DJ; Toivakka M; Kemter AM; le Bihan T; Wear M; Hoving D; Filbey KJ; Hewitson JP; Henderson H; Gonzàlez-Cìscar A; Errington C; Vermeren S; Astier AL; Wallace WA; Schwarze J; Ivens AC; Maizels RM; McSorley HJ
[Ad] Address:MRC Centre for Inflammation Research, University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.
[Ti] Title:HpARI Protein Secreted by a Helminth Parasite Suppresses Interleukin-33.
[So] Source:Immunity;47(4):739-751.e5, 2017 Oct 17.
[Is] ISSN:1097-4180
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Infection by helminth parasites is associated with amelioration of allergic reactivity, but mechanistic insights into this association are lacking. Products secreted by the mouse parasite Heligmosomoides polygyrus suppress type 2 (allergic) immune responses through interference in the interleukin-33 (IL-33) pathway. Here, we identified H. polygyrus Alarmin Release Inhibitor (HpARI), an IL-33-suppressive 26-kDa protein, containing three predicted complement control protein (CCP) modules. In vivo, recombinant HpARI abrogated IL-33, group 2 innate lymphoid cell (ILC2) and eosinophilic responses to Alternaria allergen administration, and diminished eosinophilic responses to Nippostrongylus brasiliensis, increasing parasite burden. HpARI bound directly to both mouse and human IL-33 (in the cytokine's activated state) and also to nuclear DNA via its N-terminal CCP module pair (CCP1/2), tethering active IL-33 within necrotic cells, preventing its release, and forestalling initiation of type 2 allergic responses. Thus, HpARI employs a novel molecular strategy to suppress type 2 immunity in both infection and allergy.
[Mh] MeSH terms primary: Helminth Proteins/immunology
Interleukin-33/immunology
Nematospiroides dubius/immunology
Strongylida Infections/immunology
[Mh] MeSH terms secundary: Allergens/immunology
Alternaria/immunology
Amino Acid Sequence
Animals
Blotting, Western
Eosinophils/immunology
Helminth Proteins/genetics
Helminth Proteins/metabolism
Host-Parasite Interactions/immunology
Humans
Immunity, Innate/immunology
Interleukin-33/genetics
Interleukin-33/metabolism
Lymphocytes/immunology
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Knockout
Nematospiroides dubius/genetics
Nematospiroides dubius/metabolism
Protein Binding/immunology
Receptors, Interleukin/immunology
Receptors, Interleukin/metabolism
Sequence Homology, Amino Acid
Strongylida Infections/metabolism
Strongylida Infections/parasitology
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Allergens); 0 (Helminth Proteins); 0 (Interleukin-33); 0 (Receptors, Interleukin); 0 (interleukin-33 receptor, mouse)
[Em] Entry month:1711
[Cu] Class update date: 171106
[Lr] Last revision date:171106
[Js] Journal subset:IM
[Da] Date of entry for processing:171019
[St] Status:MEDLINE

  5 / 2136 MEDLINE  
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[PMID]: 29045902
[Au] Autor:Minutti CM; Drube S; Blair N; Schwartz C; McCrae JC; McKenzie AN; Kamradt T; Mokry M; Coffer PJ; Sibilia M; Sijts AJ; Fallon PG; Maizels RM; Zaiss DM
[Ad] Address:Institute of Immunology and Infection Research, University of Edinburgh, EH9 3FL Edinburgh, UK.
[Ti] Title:Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion.
[So] Source:Immunity;47(4):710-722.e6, 2017 Oct 17.
[Is] ISSN:1097-4180
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Gastro-intestinal helminth infections trigger the release of interleukin-33 (IL-33), which induces type-2 helper T cells (Th2 cells) at the site of infection to produce IL-13, thereby contributing to host resistance in a T cell receptor (TCR)-independent manner. Here, we show that, as a prerequisite for IL-33-induced IL-13 secretion, Th2 cells required the expression of the epidermal growth factor receptor (EGFR) and of its ligand, amphiregulin, for the formation of a signaling complex between T1/ST2 (the IL-33R) and EGFR. This shared signaling complex allowed IL-33 to induce the EGFR-mediated activation of the MAP-kinase signaling pathway and consequently the expression of IL-13. Lack of EGFR expression on T cells abrogated IL-13 expression in infected tissues and impaired host resistance. EGFR expression on Th2 cells was TCR-signaling dependent, and therefore, our data reveal a mechanism by which antigen presentation controls the innate effector function of Th2 cells at the site of inflammation.
[Mh] MeSH terms primary: Interleukin-13/immunology
Interleukin-33/immunology
Receptor, Epidermal Growth Factor/immunology
Receptors, Antigen, T-Cell/immunology
Th2 Cells/immunology
[Mh] MeSH terms secundary: Amphiregulin/immunology
Amphiregulin/metabolism
Animals
Cell Line
Cells, Cultured
Gene Expression/genetics
Gene Expression/immunology
Gene Expression Profiling/methods
HEK293 Cells
Humans
Interleukin-13/genetics
Interleukin-13/metabolism
Interleukin-33/genetics
Interleukin-33/metabolism
MAP Kinase Signaling System/immunology
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Nematospiroides dubius/immunology
Nematospiroides dubius/physiology
Nocardia/immunology
Nocardia/physiology
Nocardia Infections/immunology
Nocardia Infections/metabolism
Nocardia Infections/microbiology
Receptor, Epidermal Growth Factor/genetics
Receptor, Epidermal Growth Factor/metabolism
Receptors, Antigen, T-Cell/metabolism
Reverse Transcriptase Polymerase Chain Reaction
Strongylida Infections/immunology
Strongylida Infections/metabolism
Strongylida Infections/parasitology
Th2 Cells/metabolism
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Amphiregulin); 0 (Interleukin-13); 0 (Interleukin-33); 0 (Receptors, Antigen, T-Cell); EC 2.7.10.1 (Receptor, Epidermal Growth Factor)
[Em] Entry month:1711
[Cu] Class update date: 171106
[Lr] Last revision date:171106
[Js] Journal subset:IM
[Da] Date of entry for processing:171019
[St] Status:MEDLINE

  6 / 2136 MEDLINE  
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[PMID]: 28942048
[Au] Autor:Falsone L; Colella V; Napoli E; Brianti E; Otranto D
[Ad] Address:Dipartimento di Scienze Veterinarie, Università degli Studi di Messina, Polo Universitario Annunziata 98168 Messina, Italy.
[Ti] Title:The cockroach Periplaneta americana as a potential paratenic host of the lungworm Aelurostrongylus abstrusus.
[So] Source:Exp Parasitol;182:54-57, 2017 Nov.
[Is] ISSN:1090-2449
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Aelurostrongylus abstrusus is a well-known nematode affecting the respiratory system of felids worldwide. Snails and slugs act as intermediate hosts of this parasite, whereas rodents, birds and reptiles may serve as paratenic hosts. Periplaneta americana, the American brown cockroach, shares the same habitat and ecological features (e.g. nocturnal activity) with both snails and cats. The aim of this study was to evaluate the capability of P. americana to maintain alive A. abstrusus third stage larvae (L3s) after artificial inoculation. MATERIAL AND METHODS: Twenty-five specimens of P. americana were infected with 100 A. abstrusus L3s collected from experimentally infected Cornu aspersum snails, whereas five specimens were used as control group. After the infection, cockroaches were maintained in individual plastic boxes until dissection for the presence of L3s at 1 (T1), 5 (T5), 10 (T10), 15 (T15), and 20 (T20) days post-infection. RESULTS: Except for T15, alive A. abstrusus L3s (n = 63) were found at all time-points, being 26, 19, 16 and 2 L3s retrieved at T1, T5, T10 and T20, respectively. Eleven (17.4%) L3s were found within the digestive tract, 10 (15.9%) in other-than-digestive organs and 42 (66.7%) in the exoskeleton and associated tissues. Nine out of the twenty-five experimentally inoculated cockroaches (36%) died soon after the artificial infection (T1), while in the control group, two out of the five (40%) died before the end of the study (T15) with no difference in the mortality rate between groups. DISCUSSION: Results of this study suggest that P. americana could act as a paratenic host of A. abstrusus. Periplaneta americana cockroaches, have a ubiquitous distribution and may be preyed by cats, representing a potential source of infection to cats living in endemic areas.
[Mh] MeSH terms primary: Cat Diseases/parasitology
Insect Vectors/parasitology
Metastrongyloidea/physiology
Periplaneta/parasitology
Strongylida Infections/veterinary
[Mh] MeSH terms secundary: Animals
Cat Diseases/transmission
Cats
Feces/parasitology
Metastrongyloidea/growth & development
Snails/parasitology
Strongylida Infections/transmission
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171031
[Lr] Last revision date:171031
[Js] Journal subset:IM
[Da] Date of entry for processing:170925
[St] Status:MEDLINE

  7 / 2136 MEDLINE  
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[PMID]: 28938014
[Au] Autor:Pastille E; Frede A; McSorley HJ; Gräb J; Adamczyk A; Kollenda S; Hansen W; Epple M; Buer J; Maizels RM; Klopfleisch R; Westendorf AM
[Ad] Address:Institute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
[Ti] Title:Intestinal helminth infection drives carcinogenesis in colitis-associated colon cancer.
[So] Source:PLoS Pathog;13(9):e1006649, 2017 Sep.
[Is] ISSN:1553-7374
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Inflammatory bowel diseases (IBD) are chronic inflammatory disorders of the gastrointestinal tract, strongly associated with an increased risk of colorectal cancer development. Parasitic infections caused by helminths have been shown to modulate the host's immune response by releasing immunomodulatory molecules and inducing regulatory T cells (Tregs). This immunosuppressive state provoked in the host has been considered as a novel and promising approach to treat IBD patients and alleviate acute intestinal inflammation. On the contrary, specific parasite infections are well known to be directly linked to carcinogenesis. Whether a helminth infection interferes with the development of colitis-associated colon cancer (CAC) is not yet known. In the present study, we demonstrate that the treatment of mice with the intestinal helminth Heligmosomoides polygyrus at the onset of tumor progression in a mouse model of CAC does not alter tumor growth and distribution. In contrast, H. polygyrus infection in the early inflammatory phase of CAC strengthens the inflammatory response and significantly boosts tumor development. Here, H. polygyrus infection was accompanied by long-lasting alterations in the colonic immune cell compartment, with reduced frequencies of colonic CD8+ effector T cells. Moreover, H. polygyrus infection in the course of dextran sulfate sodium (DSS) mediated colitis significantly exacerbates intestinal inflammation by amplifying the release of colonic IL-6 and CXCL1. Thus, our findings indicate that the therapeutic application of helminths during CAC might have tumor-promoting effects and therefore should be well-considered.
[Mh] MeSH terms primary: Colitis/complications
Colonic Neoplasms/etiology
Helminthiasis/complications
Intestinal Diseases, Parasitic/complications
Strongylida Infections/complications
[Mh] MeSH terms secundary: Animals
Carcinogenesis/immunology
Disease Models, Animal
Female
Flow Cytometry
Helminthiasis/immunology
Intestinal Diseases, Parasitic/immunology
Mice
Mice, Inbred BALB C
Nematospiroides dubius
Strongylida Infections/immunology
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171022
[Lr] Last revision date:171022
[Js] Journal subset:IM
[Da] Date of entry for processing:170923
[St] Status:MEDLINE
[do] DOI:10.1371/journal.ppat.1006649

  8 / 2136 MEDLINE  
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[PMID]: 28822203
[Au] Autor:Demiaszkiewicz AW; Filip KJ; Pyziel AM
[Ad] Address:W. Stefanski Institute of Parasitology, Polish Academy of Sciences, ul. Twarda 51/55, 00-818 Warsaw, Poland
[Ti] Title:The first report of Aelurostrongylus falciformis (Schlegel, 1933) (Nematoda, Metastrongyloidea) in badger (Meles meles) in Poland
[So] Source:Ann Parasitol;63(2):117-120, 2017.
[Is] ISSN:2299-0631
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:Aelurostrongylus falciformis belongs to the superfamily of Metastrongyloidea. This nematode occurs in European badgers and locates in lungs, in respiratory tract. Numerous species of land snails are intermediate hosts of the parasite. In 2015, parasitological necropsy of 9 badgers, shot in the Forest District Gleboki Bród in Augustowska Primeval Forest, was performed. Two examined animals were infected with nematodes A. falciformis. In the lungs of each badger two specimens of nematodes were detected (male and female). In the following article, description, morphometrical data and figures are presented. This is the first report of A. falciformis infection in badgers in Poland.
[Mh] MeSH terms primary: Metastrongyloidea
Mustelidae/parasitology
Strongylida Infections/veterinary
[Mh] MeSH terms secundary: Animals
Female
Male
Metastrongyloidea/anatomy & histology
Poland/epidemiology
Strongylida Infections/epidemiology
Strongylida Infections/pathology
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171017
[Lr] Last revision date:171017
[Js] Journal subset:IM
[Da] Date of entry for processing:170820
[St] Status:MEDLINE
[do] DOI:10.17420/ap6302.94

  9 / 2136 MEDLINE  
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[PMID]: 28803904
[Au] Autor:Gao JF; Liu GH; Duan H; Gao Y; Zhang Y; Chang QC; Fang M; Wang CR
[Ad] Address:College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province 163319, PR China; Department of Parasitology, Heilongjiang Institute of Veterinary Science, Qiqihar, Heilongjiang Province 161006, PR China. Electronic address: gaojunfeng_2005
[Ti] Title:Complete mitochondrial genomes of Triodontophorus serratus and Triodontophorus nipponicus, and their comparison with Triodontophorus brevicauda.
[So] Source:Exp Parasitol;181:88-93, 2017 Oct.
[Is] ISSN:1090-2449
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Triodontophorus serratus and Triodontophorus nipponicus are two of the most common nematodes inhabiting in the large intestine of horse. In the present study, the complete mitochondrial (mt) genome sequences of T. serratus and T. nipponicus have been determined. The mt genomes of T. serratus and T. nipponicus are circular molecules with 13,794 bp and 13,701 bp in size, respectively. These circular mt genomes encode 36 genes, including 12 protein-coding genes, two rRNA genes and 22 tRNA genes. All of these genes are transcribed in the same direction and gene arrangements are consistent with that of gene arrangement 3 (GA3-type). T. serratus and T. nipponicus had two non-coding regions, but T. brevicauda had three. Phylogenetic relationships were reconstructed using concatenated amino acid sequences of the 12 protein-coding genes with three methods, indicating that three species of Triodontophorus clustered together with strong statistical support. However, the genera of Strongylus and Triodontophorus belonged to Strongylinae do not cluster together, and Triodontophorus is more closely related to Cylicocyclus insigne, Cylicocyclus nassatus, Cylicostephanus goldi (Cyathostominae) than to Strongylus. The findings from the present study provide useful genetic markers for studying the molecular ecology, systematics, and population genetics of Triodontophorus in equine.
[Mh] MeSH terms primary: Genome, Mitochondrial
Horse Diseases/parasitology
Strongylida Infections/veterinary
Strongyloidea/genetics
[Mh] MeSH terms secundary: Animals
Base Composition
Cecum/parasitology
Colon/parasitology
DNA, Helminth/chemistry
DNA, Mitochondrial/chemistry
Gene Order
Genome, Mitochondrial/genetics
Horses
Phylogeny
Strongylida Infections/parasitology
Strongyloidea/classification
[Pt] Publication type:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Name of substance:0 (DNA, Helminth); 0 (DNA, Mitochondrial)
[Em] Entry month:1709
[Cu] Class update date: 170920
[Lr] Last revision date:170920
[Js] Journal subset:IM
[Da] Date of entry for processing:170815
[St] Status:MEDLINE

  10 / 2136 MEDLINE  
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[PMID]: 28759611
[Au] Autor:Kannan Y; Entwistle LJ; Pelly VS; Perez-Lloret J; Walker AW; Ley SC; Wilson MS
[Ad] Address:Allergy and Anti-helminth Immunity Laboratory, The Francis Crick Institute, London, United Kingdom.
[Ti] Title:TPL-2 restricts Ccl24-dependent immunity to Heligmosomoides polygyrus.
[So] Source:PLoS Pathog;13(7):e1006536, 2017 Jul.
[Is] ISSN:1553-7374
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:TPL-2 (COT, MAP3K8) kinase activates the MEK1/2-ERK1/2 MAPK signaling pathway in innate immune responses following TLR, TNFR1 and IL-1R stimulation. TPL-2 contributes to type-1/Th17-mediated autoimmunity and control of intracellular pathogens. We recently demonstrated TPL-2 reduces severe airway allergy to house dust mite by negatively regulating type-2 responses. In the present study, we found that TPL-2 deficiency resulted in resistance to Heligmosomoides polygyrus infection, with accelerated worm expulsion, reduced fecal egg burden and reduced worm fitness. Using co-housing experiments, we found resistance to infection in TPL-2 deficient mice (Map3k8-/-) was independent of microbiota alterations in H. polygyrus infected WT and Map3k8-/-mice. Additionally, our data demonstrated immunity to H. polygyrus infection in TPL-2 deficient mice was not due to dysregulated type-2 immune responses. Genome-wide analysis of intestinal tissue from infected TPL-2-deficient mice identified elevated expression of genes involved in chemotaxis and homing of leukocytes and cells, including Ccl24 and alternatively activated genes. Indeed, Map3k8-/-mice had a significant influx of eosinophils, neutrophils, monocytes and Il4GFP+ T cells. Conditional knockout experiments demonstrated that specific deletion of TPL-2 in CD11c+ cells, but not Villin+ epithelial cells, LysM+ myeloid cells or CD4+ T cells, led to accelerated resistance to H. polygyrus. In line with a central role of CD11c+ cells, CD11c+ CD11b+ cells isolated from TPL-2-deficient mice had elevated Ccl24. Finally, Ccl24 neutralization in TPL-2 deficient mice significantly decreased the expression of Arg1, Retnla, Chil3 and Ear11 correlating with a loss of resistance to H. polygyrus. These observations suggest that TPL-2-regulated Ccl24 in CD11c+CD11b+ cells prevents accelerated type-2 mediated immunity to H. polygyrus. Collectively, this study identifies a previously unappreciated role for TPL-2 controlling immune responses to H. polygyrus infection by restricting Ccl24 production.
[Mh] MeSH terms primary: Chemokine CCL24/immunology
MAP Kinase Kinase Kinases/immunology
Nematospiroides dubius/immunology
Proto-Oncogene Proteins/immunology
Strongylida Infections/immunology
[Mh] MeSH terms secundary: Animals
Chemokine CCL24/genetics
Female
Humans
Immunity, Innate
MAP Kinase Kinase Kinases/genetics
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Nematospiroides dubius/genetics
Nematospiroides dubius/physiology
Proto-Oncogene Proteins/genetics
Strongylida Infections/enzymology
Strongylida Infections/genetics
Strongylida Infections/parasitology
Th2 Cells/immunology
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Ccl24 protein, mouse); 0 (Chemokine CCL24); 0 (Proto-Oncogene Proteins); EC 2.7.11.25 (MAP Kinase Kinase Kinases); EC 2.7.11.25 (Map3k8 protein, mouse)
[Em] Entry month:1709
[Cu] Class update date: 170918
[Lr] Last revision date:170918
[Js] Journal subset:IM
[Da] Date of entry for processing:170801
[St] Status:MEDLINE
[do] DOI:10.1371/journal.ppat.1006536


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