Database : MEDLINE
Search on : Sweat and Gland and Neoplasms [Words]
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[PMID]: 27772650
[Au] Autor:Raven ML; Krivochenitser RI; Lucarelli MJ
[Ad] Address:Department of Ophthalmology and Visual Sciences, University of Wisconsin - Madison, Madison, Wisconsin.
[Ti] Title:Tubular Apocrine Adenoma in Association with an Apocrine Hidrocystoma.
[So] Source:Ophthalmology;123(11):2385, 2016 11.
[Is] ISSN:1549-4713
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Hidrocystoma/pathology
Sweat Gland Neoplasms/pathology
Tubular Sweat Gland Adenomas/pathology
[Mh] MeSH terms secundary: Adult
Hidrocystoma/surgery
Humans
Male
Sweat Gland Neoplasms/surgery
Tubular Sweat Gland Adenomas/surgery
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:161025
[St] Status:MEDLINE

  2 / 3751 MEDLINE  
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[PMID]: 29477759
[Au] Autor:Chauvel-Picard J; Pierrefeu A; Harou O; Breton P; Sigaux N
[Ad] Address:Chirurgie Maxillo-faciale, Stomatologie, Chirurgie Orale et Chirurgie Plastique de la face Hospices Civils de Lyon - Université Claude Bernard Lyon 1, Centre Hospitalier Lyon Sud. 165 Chemin du Grand Revoyet, 69310 Pierre-Bénite, France. Electronic address: julie.chauvelpicard@gmail.com.
[Ti] Title:Unusual cystic lesion of the eyebrow: a case report of malignant chondroid syringoma.
[So] Source:J Stomatol Oral Maxillofac Surg;, 2018 Feb 22.
[Is] ISSN:2468-7855
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Malignant chondroid syringomas, also known as cutaneous malignant mixed tumors, are rare neoplasms that most frequently occur on the torso or extremities of women. Here we present an illustrated case of a facial malignant chondroid syringoma. MATERIALS AND METHODS: A 32-year-old female patient with no notable medical history presented with an approximately 1cm-wide, painless, palpably-mobile subcutaneous nodule, suggestive of a sebaceous cyst, just above the middle third of the right eyebrow. The nodule had grown steadily over six months. She had no palpable cervical lymphadenopathies. RESULTS: Anatomic pathology of the enucleated nodule found an adnexal sudoriparous tumor measuring 6 x 10mm and indicative of a malignant chondroid syringoma. Cervicofacial computed tomography and positron emission tomography scans showed no near or distant lymph node involvement. A second intervention for wide excision around the original enucleation lesion (+ 1cm) was validated in a multidisciplinary, cancerology-dermatology consultation. The eyebrow was reconstructed with a temporally-harvested fasciocutaneous island flap. DISCUSSION: Malignant chondroid syringomas are very rare and thus no standardized treatment has been established for them. Only 12 craniofacial localizations have been described to date. Radiation therapy and chemotherapy have not been shown effective for this malignancy, leaving only wide excision as a therapeutic option. A high and sustained (as much as 20 years after the initial diagnosis) risk of recurrence or metastasis necessitates prolonged patient follow-up.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180225
[Lr] Last revision date:180225
[St] Status:Publisher

  3 / 3751 MEDLINE  
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[PMID]: 29384887
[Au] Autor:Lu H; Chen LF; Chen Q; Shen H; Liu Z
[Ad] Address:Department of Hand Surgery.
[Ti] Title:A rare large cutaneous chondroid syringoma involving a toe: A case report.
[So] Source:Medicine (Baltimore);97(5):e9825, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Chondroid syringoma (CS) occurs mostly on the face and neck, and rarely occurs in the toe. Malignant CS is invasive, grows quickly, and has a high recurrence rate. The presence of a bilobed CS in 1 toe has never been reported in the literature. PATIENT CONCERNS: A 72-year-old male patient presented with a mass in a third toe of his right foot. The mass had slowly grown in 2 years. He felt mild pain and the mass occupied most of the tip of the toe. DIAGNOSES: Radiographs showed a large soft-tissue mass in the third toe of his right foot without any bone destruction. Ultrasonogram showed 2 partly fused hypoechoic masses within the lesion. The mass was therefore diagnosed as a benign CS. INTERVENTIONS: We amputated the toe with the mass under local anesthesia. The postoperative pathohistological examinations confirmed that the lesion was a bipartite CS exhibiting active cellular proliferation. OUTCOMES: Two years after surgery, there was no tumor recurrence. LESSONS: CS can also present as multiple adjacent masses. Complete surgical resection and long-term follow-up are essential.
[Mh] MeSH terms primary: Adenoma, Pleomorphic/diagnostic imaging
Adenoma, Pleomorphic/pathology
Sweat Gland Neoplasms/diagnostic imaging
Sweat Gland Neoplasms/pathology
Toes
[Mh] MeSH terms secundary: Adenoma, Pleomorphic/surgery
Aged
Humans
Male
Radiography
Sweat Gland Neoplasms/surgery
Ultrasonography
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180221
[Lr] Last revision date:180221
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009825

  4 / 3751 MEDLINE  
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[PMID]: 29174934
[Au] Autor:Wick MR
[Ad] Address:Division of Surgical Pathology & Cytopathology, University of Virginia Medical Center, Room 3020, 1215 Lee St., Charlottesville, VA 22908-0214, USA. Electronic address: mrwick1@usa.net.
[Ti] Title:Primary lesions that may imitate metastatic tumors histologically: A selective review.
[So] Source:Semin Diagn Pathol;35(2):123-142, 2018 Mar.
[Is] ISSN:0740-2570
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Several primary pathologic entities in diverse anatomic locations have the potential to simulate metastatic neoplasms histologically. Their misinterpretation as such may result in needless and extensive clinical evaluations that are intended to detect a presumed malignancy at another site. More importantly, mistakes of this type can deprive patients of surgical excisions that could be curative. This presentation considers a review of selected primary lesions that can simulate metastases. They include hemangioblastoma, glioblastoma and meningioma with epithelial metaplasia, choroid plexus carcinomas, primary neuroendocrine carcinomas in unusual locations, special forms of sinonasal and salivary glandular adenocarcinoma, clear-cell thyroid carcinomas, unusual microscopic subtypes of pulmonary adenocarcinoma, epithelioid myomelanocytomas ("sugar tumors"), mesotheliomas, primary thymic carcinomas, endodermal choristomas of the interatrial myocardium, peripheral cholangiocarcinoma, adrenocortical carcinoma, adenocarcinomas of the urinary bladder, mucinous and "rhabdoid" tumors of the ovaries, rete testis adenocarcinomas, interdigitating dendritic-cell sarcoma of lymph nodes, selected sweat gland carcinomas, cutaneous Merkel cell carcinoma, primary dermal and subcutaneous melanoma, mucosal and visceral melanomas, epithelioid sarcoma, clear-cell sarcoma, and adamantinoma of long bones. Differential diagnostic observations are emphasized in reference to those lesions.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1711
[Cu] Class update date: 180221
[Lr] Last revision date:180221
[St] Status:In-Data-Review

  5 / 3751 MEDLINE  
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[PMID]: 29436004
[Au] Autor:Miura K; Akashi T; Ando N; Ayabe S; Kayamori K; Namiki T; Eishi Y
[Ad] Address:Division of Surgical Pathology, Tokyo Medical and Dental University Hospital, Tokyo, Japan.
[Ti] Title:Homeobox transcriptional factor engrailed homeobox 1 is specifically expressed in normal and neoplastic sweat gland cells.
[So] Source:Histopathology;, 2018 Feb 12.
[Is] ISSN:1365-2559
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:AIM: A number of homeobox transcriptional factors are utilized as organ-specific markers in the histopathological diagnosis of neoplasms. We have screened a homeobox gene that is specifically expressed in normal sweat gland cells and is useful for the histopathological diagnosis of sweat gland neoplasms. METHODS AND RESULTS: By screening an open database resource of The Human Protein Atlas, 37 genes among the 235 homeobox transcriptional factors were found to be specifically expressed in the skin. Among those 37 genes, the engrailed homeobox 1 (En1) was expressed in normal eccrine glands but not in the epidermal keratinocytes. Expression of En1 was found throughout the eccrine glands, but not in the apocrine secretory coils, sebaceous glands, or hair follicles. Expression of En1 was immunohistochemically examined in 111 cases of cutaneous epithelial neoplasms. All the 9 cases of poroma, 7 cases of spiradenoma, and 6 cases of syringoma, which are considered to differentiate toward eccrine glands, showed positive nuclear staining in most of the tumour cells. Sebaceous gland and hair follicle tumours were immuno-negative. En1 was focally expressed in the epidermal neoplasms of seborrheic keratosis and squamous cell carcinoma. CONCLUSION: En1 was specifically expressed in normal eccrine glands and was expressed in most of the tumour cells of sweat gland neoplasms with eccrine gland differentiation. En1 was focally expressed in epidermal neoplasms, however, it was absent in sebaceous or hair follicle neoplasms. These findings will help in the histopathological diagnosis as well as to understand the histogenesis of sweat gland neoplasms. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[St] Status:Publisher
[do] DOI:10.1111/his.13486

  6 / 3751 MEDLINE  
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[PMID]: 29388236
[Au] Autor:Lee JY; Kang BS; Shim HS; Song IH; Kim M; Lee SH; Chung HW; Lee MH; Shin MJ
[Ad] Address:Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
[Ti] Title:Clear Cell Hidradenoma: Characteristic Imaging Features on Ultrasonography, Computed Tomography, and Magnetic Resonance Imaging.
[So] Source:J Ultrasound Med;, 2018 Feb 01.
[Is] ISSN:1550-9613
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVES: The purpose of this study was to evaluate the imaging features of clear cell hidradenoma on ultrasonography (US), computed tomography (CT), and magnetic resonance imaging (MRI). METHODS: The radiologic and pathologic databases at 2 medical institutions were searched retrospectively from 2004 to 2016 to identify patients with a diagnosis of clear cell hidradenoma. Ultrasonographic, CT, and MRI features were described, and pathologic specimens were reviewed. RESULTS: There were 5 female and 4 male patients. The mean patient age was 48.9 years (range, 28-70 years). Five patients underwent only US; 2 patients underwent only CT; 1 patient underwent both US and CT; and 1 patient underwent US and MRI. Most of the tumors were located primarily in the subcutaneous fat layer. The mean tumor size was 18.4 mm. On US, 6 masses had a heterogeneous echo texture, including an anechoic portion with protruding echogenic portions. Two masses had multiple septa in the anechoic portion. On color Doppler US, blood flow was both central and peripheral in 5 patients. All 3 cases seen on CT presented as a low-attenuation mass with an enhanced solid internal nodule. On MRI, the mass showed heterogeneous signal intensity on T2-weighted images and enhancement of the peripheral wall and internal solid component on contrast-enhanced T1-weighted images. CONCLUSIONS: Clear cell hidradenoma is usually located in the subcutaneous fat layer, has a well-defined margin, appears as a cystic mass with an internal solid nodule, and occasionally has multiple septa on US, CT, and MRI.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180201
[Lr] Last revision date:180201
[St] Status:Publisher
[do] DOI:10.1002/jum.14552

  7 / 3751 MEDLINE  
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[PMID]: 29271484
[Au] Autor:Kwon KE; Kim SJ; Choi HJ; Jung YY; Park NH; Park JY; Baek SH
[Ad] Address:Department of Radiology, Myongji Hospital, Seonam University College of Medicine, 55, Hwasu-ro 14 beon-gil, Deogyang-gu, Goyang-si, Gyeonggi-do, Republic of Korea.
[Ti] Title:Sonographic appearance of an eccrine spiradenoma: A case report.
[So] Source:J Clin Ultrasound;, 2017 Dec 22.
[Is] ISSN:1097-0096
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Eccrine spiradenoma is a rare, benign, adnexal skin tumor of the sweat gland, which may manifest in any part of the body. It is typically located in the dermal or the subcutaneous fat layer. Eccrine spiradenomas rarely progress to malignant transformation and only a few cases of malignant transformation have been reported. Due to its rarity, there have been few reports about the sonographic appearances of eccrine spiradenoma. We report the sonographic findings in one case of eccrine spiradenoma, located in the subcutaneous fat and the deep dermal layers of the upper arm in a middle-aged woman.
[Pt] Publication type:CASE REPORTS
[Em] Entry month:1712
[Cu] Class update date: 171222
[Lr] Last revision date:171222
[St] Status:Publisher
[do] DOI:10.1002/jcu.22572

  8 / 3751 MEDLINE  
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[PMID]: 29241739
[Au] Autor:Liau JY; Tsai JH; Huang WC; Lan J; Hong JB; Yuan CT
[Ad] Address:Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Graduate Institute of Pathology, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address: 019188@ntuh.gov.tw.
[Ti] Title:BRAF and KRAS mutations in tubular apocrine adenoma and papillary eccrine adenoma of the skin.
[So] Source:Hum Pathol;, 2017 Dec 11.
[Is] ISSN:1532-8392
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Tubular apocrine adenoma (TAA) and papillary eccrine adenoma (PEA) are benign sweat gland tumors. Their names imply that they exhibit apocrine and eccrine differentiation, respectively. However, morphologically they are very similar and are often indistinguishable. The molecular pathogenesis of either tumor is poorly understood at present. On the basis of an index case of nipple adenoma that was morphologically reminiscent of cutaneous TAA/PEA and harbored a BRAF mutation, we investigated whether a similar genetic change is also present in TAA/PEA. BRAF, RAS, and PIK3CA mutation analyses, and BRAF -specific immunohistochemistry were performed for 24 TAAs/PEAs, 10 eccrine poromas, 7 apocrine cystadenomas, 2 TAA-like adenomas associated with nevus sebaceus, and one apocrine adenoma probably arising in anogenital mammary-like glands (AGMLGs). The results demonstrated that BRAF mutations were present in TAAs (9/15, 60%) and PEAs (7/9, 78%), but not in other neoplasms. Two additional TAAs harbored KRAS mutations. In addition, a KRAS mutation was identified in one nevus sebaceus-associated TAA-like adenoma. The speculated AGMLG-related apocrine adenoma had a PIK3CA mutation. We concluded that activating BRAF and KRAS mutations were commonly present in TAAs/PEAs, indicating that in addition to a morphological resemblance, they are closely related genetically. Therefore, they could be considered to be united as a single entity. By contrast, the apocrine adenoma probably arising in AGMLG harbored a PIK3CA mutation, which is also commonly present in hidradenoma papilliferum. Further studies are necessary to determine whether the pathogenesis of AGMLG-related tumors is similar to breast tumors.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171215
[Lr] Last revision date:171215
[St] Status:Publisher

  9 / 3751 MEDLINE  
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[PMID]: 29120034
[Au] Autor:Hwang CM; Kang BS; Hong HJ; Lee JY; Suh JH; Han EM; Song IH; Shim HS; Lee SH
[Ad] Address:Department of Diagnostic Radiology, Konyang University Hospital, College of Medicine, Daejeon, Korea.
[Ti] Title:Ultrasonographic Features of Eccrine Spiradenoma.
[So] Source:J Ultrasound Med;, 2017 Nov 09.
[Is] ISSN:1550-9613
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The purpose of this series was to evaluate the features of eccrine spiradenoma on ultrasonography (US). We reviewed the clinical data of 8 patients with eccrine spiradenoma who underwent preoperative US at 4 different medical institutions from 2004 to 2016 and analyzed the US features in terms of the tumor location, size, shape, margin, echo texture, echogenicity, posterior acoustic enhancement, calcification, septum, and color Doppler flow. There were 7 female patients and 1 male patient. The mean patient age was 45.6 years (range, 28-60 years). Most of the tumors were located primarily in the subcutaneous fat layer. The mean size of the tumors was 14.3 mm. The masses had a lobular appearance in 7 patients and had a tractlike structure in 3 patients. In 6 patients, the masses had a heterogeneous echo texture. Six cases showed hypoechogenicity with more hypoechoic foci in the masses, and 2 cases showed hypoechogenicity only. Color Doppler flow was evaluated in 7 patients; the blood flow was central and peripheral in 4 patients and only peripheral in 3 patients. All cases showed posterior acoustic enhancement and had well-defined margins. Calcification and septa were not seen in any cases. Eccrine spiradenoma is usually located in the subcutaneous fat layer, has a well-defined margin, a lobulated appearance, occasionally with a tractlike structure, a heterogeneous echo texture, a hypoechoic appearance with internal hypoechoic foci and posterior acoustic enhancement, and shows blood flow in the peripheral portion, with or without blood flow in the central portion.
[Pt] Publication type:CASE REPORTS
[Em] Entry month:1711
[Cu] Class update date: 171109
[Lr] Last revision date:171109
[St] Status:Publisher
[do] DOI:10.1002/jum.14460

  10 / 3751 MEDLINE  
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[PMID]: 28954110
[Au] Autor:Abarzúa Á; Álvarez-Véliz S; Moll-Manzur C
[Ad] Address:Department of Dermatology, Faculty of Medicine, Pontificia Universidad Católica de Chile - Santiago, Chile.
[Ti] Title:Concomitant poroma and porocarcinoma.
[So] Source:An Bras Dermatol;92(4):550-552, 2017 Jul-Aug.
[Is] ISSN:1806-4841
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:Eccrine poromas and porocarcinomas are adnexal tumors derived from the sweat duct epithelium. However, eccrine poroma is benign in nature, whilst eccrine porocarcinoma is regarded as its malignant counterpart. We report the case of a man who presented simultaneously with an eccrine poroma and eccrine porocarcinoma. Both lesions had no clear distinctive features, enhancing the need of high-level clinical suspicion together with surgical excision and histopathology for prompt diagnosis confirmation.
[Mh] MeSH terms primary: Eccrine Porocarcinoma/pathology
Neoplasms, Multiple Primary/pathology
Poroma/pathology
Sweat Gland Neoplasms/pathology
[Mh] MeSH terms secundary: Aged
Biopsy
Diagnosis, Differential
Eccrine Porocarcinoma/diagnosis
Humans
Male
Neoplasms, Multiple Primary/diagnosis
Poroma/diagnosis
Sweat Gland Neoplasms/diagnosis
[Pt] Publication type:CASE REPORTS
[Em] Entry month:1710
[Cu] Class update date: 171010
[Lr] Last revision date:171010
[Js] Journal subset:IM
[Da] Date of entry for processing:170928
[St] Status:MEDLINE


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