Database : MEDLINE
Search on : Takotsubo and Cardiomyopathy [Words]
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[PMID]: 29522631
[Au] Autor:Carísimo E; Fantacone N; Fadel D
[Ad] Address:Sociedad Argentina de Cardiología.
[Ti] Title:Enfermedad de Takotsubo: el binomio mente-cuerpo. [Takotsubo cardiomyopathy: The mind-body continuum].
[So] Source:Vertex;XXVIII(132):112-116, 2017 Mar.
[Is] ISSN:0327-6139
[Cp] Country of publication:Argentina
[La] Language:spa
[Ab] Abstract:Takotsubo disease, also called "apical ballooning syndrome", "stress cardiomyopathy" or "broken-heart syndrome" is a potentially lethal entity. It is usually triggered by psychological or physical stress, either individual or collective, as a traumatic experience which is sudden and acute. Clinical presentation is usually accompanied by severe myocardial failure, which generally requires hemodynamic support in Cardiovascular Care Unit.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review

  2 / 3443 MEDLINE  
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[PMID]: 29514624
[Au] Autor:Mattsson E; Saliba-Gustafsson P; Ehrenborg E; Tornvall P
[Ad] Address:Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Sjukhusbacken 10, 11883, Stockholm, Sweden.
[Ti] Title:Lack of genetic susceptibility in takotsubo cardiomyopathy: a case-control study.
[So] Source:BMC Med Genet;19(1):39, 2018 Mar 07.
[Is] ISSN:1471-2350
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Takotsubo cardiomyopathy (TCM), also known as "broken heart syndrome", is a type of heart failure characterized by transient ventricular dysfunction in the absence of obstructive coronary lesions. Although associated with increased levels of catecholamines, pathophysiological mechanisms are unknown. Relapses and family heritability indicate a genetic predisposition. Several small studies have investigated associations between three different loci; the ß1-adrenic receptor (ADRB1), G-protein-coupled receptor kinase 5 (GRK5), Bcl-associated athanogene 3 (BAG3) and TCM but no consensus has been reached. METHODS: Participants were recruited using the Swedish Coronary Angiography and Angioplasty Register (SCAAR). TCM patients without coronary artery disease (CAD)(n = 258) were identified and age- and sex-matched subjects with (n = 164) and without (n = 243) CAD were selected as controls. DNA was isolated from saliva and genotyped for candidate single nucleotide polymorphisms in the ADRB1, GRK5 and BAG3 genes. Allele frequencies and Odds Ratios (OR) with 95% Confidence Intervals (CI) for the investigated polymorphisms were compared, respectively calculated for TCM patients and controls. RESULTS: There were no differences in allele frequencies between TCM patients and controls. OR (CI) for TCM patients having at least one minor allele using controls as reference were 1.07 (0.75-1.55) for ADRB1, 0.45 (0.11-1.85) for GRK5 and 1.27 (0.74-2.19) for BAG3. CONCLUSION: By genotyping a large takotsubo cohort, we demonstrate a lack of association between candidate SNPs in the ADRB1, GRK5 and BAG3 genes, earlier suggested to contribute to TCM. Our result indicates a need to expand the search for new genetic candidates contributing to TCM.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Data-Review
[do] DOI:10.1186/s12881-018-0544-6

  3 / 3443 MEDLINE  
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[PMID]: 29471698
[Au] Autor:Titterington JS; Hung OY; Saraf AP; Wenger NK
[Ad] Address:a Department of Medicine, Division of Cardiology , Emory University School of Medicine , Atlanta , GA , USA.
[Ti] Title:Gender differences in acute coronary syndromes: focus on the women with ACS without an obstructing culprit lesion.
[So] Source:Expert Rev Cardiovasc Ther;:1-8, 2018 Mar 07.
[Is] ISSN:1744-8344
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:INTRODUCTION: The etiologies of acute coronary syndromes (ACS) in women expand beyond the traditional paradigm of obstructive epicardial atherosclerotic disease and plaque rupture. Fundamental differences in pathobiology and presentation can partially explain the gender disparity in ACS diagnosis and management, but there is also much we do not know about the spectrum of coronary artery disease in women. Areas covered: This review seeks to explain some key differences between men and women in terms of risk factors, pathophysiology, and clinical presentations, as well as identify areas where more data are needed, focusing on women presenting with ACS but without a culprit lesion to explain their presentation. Literature search was undertaken with PubMed and Google Scholar. Expert commentary: Women with acute coronary syndromes but without plaque rupture or obstructive epicardial atherosclerosis can be difficult to diagnose and manage. Improving care in this underdiagnosed and undertreated population will require early identification of at risk patients, development of better diagnostic strategies, and standardized implementation of guideline-based therapies.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1080/14779072.2018.1443808

  4 / 3443 MEDLINE  
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[PMID]: 29351624
[Au] Autor:Malik H; Kangaharan N; Agahari I
[Ad] Address:Royal Adelaide Hospital, SA, Australia.
[Ti] Title:Takotsubo Cardiomyopathy Associated With Work-Place Bullying.
[So] Source:Occup Med (Lond);68(1):67-69, 2018 Feb 16.
[Is] ISSN:1471-8405
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Background: Takotsubo cardiomyopathy (TC) is a condition of transient left ventricular dysfunction precipitated by acute physical or emotional stress. The pathogenesis of TC is not well understood, but it is known to predominantly affect postmenopausal women in the context of physical or emotional triggers. Aims: To describe a case of TC with an association to a never previously described work place stressor of bullying. Case Report: A 48-year-old female lawyer developed acute chest pain after experiencing significant emotional distress at a workplace meeting. She had experienced 18 months of increasing work-related mental stress in a new managerial role. She was initially thought to have a non-ST-elevation myocardial infarction (NSTEMI) with widespread T wave inversion on electrocardiogram and elevated serial troponin. However, a diagnosis of TC was subsequently made given the characteristic apical ballooning morphology of the left ventricle found on echocardiogram, normal coronary arteries on angiography and a normal echocardiogram 3 weeks later. This case report describes TC in a younger demographic and a link with workplace bullying. Conclusions: Chronic workplace bullying has the potential for serious physical harm by precipitating Takotsubo cardiomyopathy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Data-Review
[do] DOI:10.1093/occmed/kqx155

  5 / 3443 MEDLINE  
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[PMID]: 29503405
[Au] Autor:Watanabe M; Izumo M; Akashi YJ
[Ad] Address:Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine.
[Ti] Title:Novel Understanding of Takotsubo Syndrome.
[So] Source:Int Heart J;, 2018 Mar 05.
[Is] ISSN:1349-3299
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:Takotsubo cardiomyopathy is described as a transient reversible cardiomyopathy which typically occurs in older women after emotional or physical stress. This cardiomyopathy is also recognized as a "syndrome" because it develops in conjunction with various diseases. Since the clinical presentation of takotsubo syndrome (TTS) is similar to acute coronary syndrome (ACS), TTS should be distinguished from ischemic heart disease. Although the pathophysiology of TTS has not well been established, a number of its specific features have been suggested. The predictor of mortality in TTS is still unknown. In this review article, we describe a series of treatment decisions in TTS.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:Publisher
[do] DOI:10.1536/ihj.17-586

  6 / 3443 MEDLINE  
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[PMID]: 29498367
[Au] Autor:Elikowski W; Malek-Elikowska M; Lazowski S; Zawodna M; Fertala N; Bryl M
[Ad] Address:Józef Strus Hospital, Poznan, Poland: Department of Internal Medicine.
[Ti] Title:Takotsubo cardiomyopathy in a young male with lung cancer and neoplastic embolization of the coronary microcirculation.
[So] Source:Pol Merkur Lekarski;44(260):54-59, 2018 Feb 23.
[Is] ISSN:1426-9686
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:The associations between stress-induced takotsubo cardiomyopathy (TC) and cancer or its therapy have been studied with increasing interest in recent years. Different mechanisms of TC development in neoplastic disease are suggested, including a decreased threshold for stress stimuli or aggravated heart adrenoreceptors sensitivity. The action of cytokines and reactive oxygen species on the myocardium, on the epicardial arteries as well as on the coronary microcirculation is also taken into consideration. The authors describe a case of a 30-year-old male with lung cancer, after immunotherapy with checkpoint inhibitors followed by two lines of chemotherapy and after pericardial and pleural drainage. He was admitted to hospital due to severe heart failure (HF) with echocardiographic features of apical TC. During symptomatic treatment of HF his state temporarily improved and left ventricular function returned to normal. Unfortunately, a few days later, he died. The autopsy revealed histological features of TC (contraction band necrosis), cardiac infiltration by cancer and the presence of cancer cells in the coronary microcirculation, which was not previously reported in TC patients. The authors emphasize that disseminated neoplastic embolization of the coronary microcirculation may be important in TC pathogenesis in some cancer patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:In-Data-Review

  7 / 3443 MEDLINE  
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[PMID]: 29332781
[Au] Autor:Pearson TE; Frizzola MA; Priest MA; Rochman MF; Froehlich CD
[Ad] Address:Department of Nursing, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE. Electronic address: thomas.pearson@nemours.org.
[Ti] Title:Pediatric Extracorporeal Cardiopulmonary Resuscitation Patient With Traumatic Subarachnoid Hemorrhage and Takotsubo Syndrome.
[So] Source:Air Med J;37(1):64-66, 2018 Jan - Feb.
[Is] ISSN:1532-6497
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Takotsubo syndrome is rare in pediatric patients but must be considered in patients with subarachnoid hemorrhage with pulmonary edema and cardiomyopathy. A systematic, collaborative approach is needed to facilitate emergent transfer of patients where extracorporeal cardiopulmonary resuscitation (e-CPR) is used as a lifesaving measure. Extracorporeal membrane oxygenation (ECMO) use in transport requires preplanning, role delineation, resources, and research efforts to be successful. We present an unusual transport case of successful e-CPR/ECMO treatment of Takotsubo syndrome in a 12-year-old boy with an isolated traumatic intracranial injury, cardiomyopathy with pulmonary edema, and multiple cardiac arrests.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180226
[Lr] Last revision date:180226
[St] Status:In-Data-Review

  8 / 3443 MEDLINE  
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[PMID]: 29466217
[Au] Autor:Muksinova MD; Shilova AS; Gilyarov MY; Konstantinova EV; Nesterov AP; Udovichenko AE; Svet AV
[Ad] Address:Federal State Budgetary Educational Institution of Higher Education "I. M. Sechenov First Moscow State Medical University" of the Ministry of Health of the Russian Federation.
[Ti] Title:[Takotsubo Cardiomyopathy as a Consequence of Myocardial Infarction. It is Possible?]
[So] Source:Kardiologiia;57(12):97-104, 2017 Dec.
[Is] ISSN:0022-9040
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:Takotsubo cardiomyopathy (TCM) is a well-known complication of many conditions associated with emotional or physical stress. Abnormal catecholamine release has been hypothesized to be the main cause of TCM. Myocardial infarction (MI) is associated with release of large amounts of catecholamines. We present here two cases in which patients simultaneously suffered from acute MI and TCM. In these elderly women without prior history of severe somatic diseases we have not revealed any external stressing factor responsible for the initiation of the disease. Therefore, we have considered primary coronary event (acute MI) to be a triggering factor of TCM manifestation.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180221
[Lr] Last revision date:180221
[St] Status:In-Data-Review

  9 / 3443 MEDLINE  
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[PMID]: 29458995
[Au] Autor:Spartalis M; Voudris V; Iliopoulos DC; Spartalis E; Siasos G
[Ad] Address:Division of Cardiology, Onassis Cardiac Surgery Center, Athens, Greece; ESC Working Group on Thrombosis, Sophia Antipolis, Cannes, France. Electronic address: msparta@med.uoa.gr.
[Ti] Title:Acute transient myocardial ischemia: A common pathophysiological mechanism in takotsubo syndrome. Is it still a cardiomyopathy?
[So] Source:J Cardiol;, 2018 Feb 16.
[Is] ISSN:1876-4738
[Cp] Country of publication:Netherlands
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1802
[Cu] Class update date: 180220
[Lr] Last revision date:180220
[St] Status:Publisher

  10 / 3443 MEDLINE  
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[PMID]: 29330935
[Au] Autor:Chinali M; Formigari R; Grutter G
[Ad] Address:Echocardiography Laboratory, Division of Pediatric Cardiology and Arrhythmology, Department of Pediatric Cardiology and Cardiac Surgery, Bambino Gesù Children Hospital-IRCSS, Rome, Italy.
[Ti] Title:Takotsubo cardiomyopathy in a young adult with transplanted heart: what happened to denervation?
[So] Source:ESC Heart Fail;5(1):197-200, 2018 Feb.
[Is] ISSN:2055-5822
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:This manuscript describes the first report of takotsubo cardiomyopathy in a young heart transplant recipient following angry debate. Our patient is a 21-year-old woman with cardiac transplant performed owing to right ventricular failure in congenital heart disease. Positive echocardiography with typical asymmetry of regional function, positive enzymes, and negative biopsy and angiography met the criteria for the diagnosis of takotsubo cardiomyopathy. Patient was discharged after 1 week in good clinical conditions and fully recovered cardiac function. The development of takotsubo cardiomyopathy in transplanted heart suggests that re-innervation occurs, thus representing a target for catecholamine-induced cardiac dysfunction.
[Pt] Publication type:CASE REPORTS
[Em] Entry month:1801
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[St] Status:In-Data-Review
[do] DOI:10.1002/ehf2.12242


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