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[PMID]: 29322840
[Au] Autor:Medeiros AF; Costa IS; Carvalho FMC; Kiyota S; Souza BBP; Sifuentes DN; Serquiz RP; Maciel BLL; Uchôa AF; Santos EAD; Morais AHA
[Ad] Address:a Postgraduate Biochemistry Program, Biosciences Center , Federal University of Rio Grande do Norte , Natal , Brazil.
[Ti] Title:Biochemical characterisation of a Kunitz-type inhibitor from Tamarindus indica L. seeds and its efficacy in reducing plasma leptin in an experimental model of obesity.
[So] Source:J Enzyme Inhib Med Chem;33(1):334-348, 2018 Dec.
[Is] ISSN:1475-6374
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:A trypsin inhibitor isolated from tamarind seed (TTI) has satietogenic effects in animals, increasing the cholecystokinin (CCK) in eutrophy and reducing leptin in obesity. We purified TTI (pTTI), characterised, and observed its effect upon CCK and leptin in obese Wistar rats. By HPLC, and after amplification of resolution, two protein fractions were observed: Fr1 and Fr2, with average mass of [M + 14H] = 19,594,690 Da and [M + 13H] = 19,578,266 Da, respectively. The protein fractions showed 54 and 53 amino acid residues with the same sequence. pTTI presented resistance to temperature and pH variations; IC was 2.7 × 10 mol.L and Ki was 2.9 × 10 mol.L . The 2-DE revealed spots with isoelectric points between pH 5 and 6, and one near pH 8. pTTI action on leptin decrease was confirmed. We conclude that pTTI is a Kunitz trypsin inhibitor with possible biotechnological health-related application.
[Mh] MeSH terms primary: Anti-Obesity Agents/pharmacology
Disease Models, Animal
Leptin/blood
Obesity/blood
Obesity/drug therapy
Peptides/pharmacology
Plant Proteins/pharmacology
Tamarindus/chemistry
[Mh] MeSH terms secundary: Animals
Anti-Obesity Agents/chemistry
Anti-Obesity Agents/isolation & purification
Dose-Response Relationship, Drug
Male
Obesity/metabolism
Peptides/chemistry
Peptides/isolation & purification
Plant Proteins/chemistry
Plant Proteins/isolation & purification
Rats
Rats, Wistar
Seeds/chemistry
Structure-Activity Relationship
Trypsin/metabolism
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Anti-Obesity Agents); 0 (Kunitz-type protease inhibitor, plant); 0 (Leptin); 0 (Peptides); 0 (Plant Proteins); EC 3.4.21.4 (Trypsin)
[Em] Entry month:1801
[Cu] Class update date: 180115
[Lr] Last revision date:180115
[Js] Journal subset:IM
[Da] Date of entry for processing:180112
[St] Status:MEDLINE
[do] DOI:10.1080/14756366.2017.1419220

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[PMID]: 29257757
[Au] Autor:Bhat TA; Begum W
[Ad] Address:Department of Obstetrics and Gyneacology, National Institute of Unani Medicine, Bangalore, India.
[Ti] Title:Efficacy of Tamarindus indicus, Melia azadirach and Santalum album in syndromic management of abnormal vaginal discharge: A single-blind randomised controlled trial.
[So] Source:J Complement Integr Med;, 2017 Dec 19.
[Is] ISSN:1553-3840
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Background At least 25 % of women attending genitourinary medicine (GUM) clinics receive treatment for one of the three common causes of abnormal vaginal discharge: bacterial vaginosis, candidiasis and trichomoniasis. Syndromic diagnostic approach was adopted by National AIDS Control Organisation (NACO) India, at the primary health centre level. Syndromic management implies the simultaneous treatment of two or more infections. The aim of this study was to assess efficacy of sandal sufaid, maghze tukhme bakayin and khaste tamar hindi in syndromic management of Sailanur rehm. Methods This study was a randomized, single blind, standard controlled trial. It was conducted to compare efficacy of formulation which contains buradae sandal safaid, safoofe maghze tukhme bakayin, safoofe khaste tamar hindi and safoofe shakkar safaid against combination of azithromycin, fluconazole and secnidazole on diagnosed subjects of Sailanur rehm. Test group received 10 g of test drug B.D for 21 days while control group received single dose of standard drug to both the partners. Vaginal symptom score (VSS) was used for assessing discharge and associated complaints. Visual analogous scale (VAS) was used for assessing low backache and lower abdominal pain. Results There were no significant differences between the two groups concerning baseline characteristics (p>0.05). VSS was significantly decreased with p<0.001 for both control and test group. VAS was significantly decreased with p<0.001 and p=0.07 in test and control group respectively for low backache. For lower abdominal pain p=0.006 for both groups after the completion of treatment. Conclusions The formulation can effectively alleviate the disease with associated symptoms without any side effects. It can be used in syndromic management of vaginal discharge. Future research is on large sample size.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171219
[Lr] Last revision date:171219
[St] Status:Publisher

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[PMID]: 29235047
[Au] Autor:Assefa A; Kechero Y; Tolemariam T; Kebede A; Shumi E
[Ad] Address:College of Agriculture and Natural Resource, Gambella University, P.O. Box 126, Gambella, Ethiopia. ashuashe@gmail.com.
[Ti] Title:Anthelmintic effects of indigenous multipurpose fodder tree extracts against Haemonchus contortus.
[So] Source:Trop Anim Health Prod;, 2017 Dec 12.
[Is] ISSN:1573-7438
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Condensed tannins (CT) extracted from Balanites aegyptiaca, Tamarindus indica, and Celtis toka browses were used to evaluate their anthelmintic effect on different developmental stages of Haemonchus contortus. To achieve this objective, various serial concentrations of each CT extract of the foliages were used to test adult motility, inhibition of egg hatchability, and larval development. The fodders were selected based on their multipurpose advantage and accessibility to use as fodder for livestock in the low lands of the Gambella region. The fastest and slowest adult motility rate was observed in 2-ml (4 min) and 0.125-ml dose of C. toka, respectively, which is better than that in ivermectin. Egg hatchability inhibition was observed with dose difference within species, but there is no difference between B. aegyptiaca and T. indica. The foliage extracts of the studied browses were observed to inhibit the larvae by 100% at 2 ml, which is similar to ivermectin. There is no significant difference observed in larvae development inhibition between the species and ivermectin (p > 0.05). CT extracts of studied plants have found to own significant anthelmintic activity in a dose-dependent manner. They could serve as anthelmintic economically and eco-friendly after further and series of in vivo experiments.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171213
[Lr] Last revision date:171213
[St] Status:Publisher
[do] DOI:10.1007/s11250-017-1488-0

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[PMID]: 29203351
[Au] Autor:Uchenna UE; Shori AB; Baba AS
[Ad] Address:Biomolecular Research Group, Division of Biochemistry, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
[Ti] Title:Tamarindus indica seeds improve carbohydrate and lipid metabolism: An in vivo study.
[So] Source:J Ayurveda Integr Med;, 2017 Dec 01.
[Is] ISSN:0975-9476
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: The tamarind seeds have a lot of nutrients that may be used to control cholesterol or glucose levels. OBJECTIVES: The effects of tamarind seeds (T) on lipid and carbohydrate metabolism in rats were studied. Rats were offered basal diet (BD) with T (2%, 4% or 8%) or without T. MATERIALS AND METHODS: Feeding and growth performance in rats were measured and samples of liver and blood were analyzed for glycogen content and levels of cholesterol and glucose respectively. RESULTS: The inclusion of T in the diet influences the feeding and growth performance in rats. The serum cholesterol level was reduced (p < 0.05) in Sprague Dawley (SD) rats fed on basal diet (BD) containing 4% and 8% T (0.24 ± 0.14 g/l and 0.31 ± 0.06 g/l respectively) compared to control (0.79 ± 0.04 g/l). The serum glucose levels in the spontaneous hypertensive rats (SHR) was lower (50.74 ± 2.50 mg/dl; p < 0.05) than control (93.52 ± 10.83 mg/dl) at 4% T. Incorporation of increasing doses of T resulted in linear increase of glycogen storage in livers of SD rats fed on BD and high sucrose diet. CONCLUSION: Tamarind seeds can lower blood glucose and serum cholesterol and enhance storage of glycogen in rats.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171205
[Lr] Last revision date:171205
[St] Status:Publisher

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[PMID]: 28951709
[Au] Autor:Waqas MK; Khan BA; Akhtar N; Chowdhry F; Khan H; Bakhsh S; Khan S; Rasul A
[Ad] Address:Institute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore, Pakistan.
[Ti] Title:Fabrication of seeds extract loaded-cream for photo-aged skin: Visioscan studies.
[So] Source:Postepy Dermatol Alergol;34(4):339-345, 2017 Aug.
[Is] ISSN:1642-395X
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Intracellular and extracellular oxidative stress triggered by free radicals promotes skin aging, which is designated by atypical pigmentation and wrinkles. The consumption of antioxidants is an efficacious measure to avert symptoms involved in skin aging. AIM: The current research was commenced to explore the anti-aging potential of antioxidants present in seeds extract. MATERIAL AND METHODS: seeds extract was obtained by concentrating the ethanolic extract of seeds. The antioxidant activities of the extract were measured by nitric oxide radical scavenging assay, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, hydroxyl radical scavenging assay and superoxide radical scavenging assay. Formulation comprising 4% of the concentrated extract of seeds was formulated by loading it in the internal aqueous phase of water-in-oil (W/O) cosmetic emulsion. The base, used as control, consisted of the same emulsion but without loading seeds extract. The cosmetic emulsions were applied to the cheeks of 11 healthy male volunteers for duration of 12 weeks. Both base and formulation were assessed for their antioxidant effects on different skin parameters i.e. skin moisture contents, elasticity and surface evaluation of living skin (SELS). RESULTS: The formulation showed statistically significant ( ≤ 0.05) and the base showed insignificant ( > 0.05) effects on skin elasticity and skin moisture contents. There is a significant decline in SELS, skin scaliness (SEsc), skin wrinkles (SEw), skin smoothness (SEsm), and skin roughness (SEr) parameters after application of the formulation. CONCLUSIONS: Topical application of the cosmetic emulsion entrapped with seeds extract containing various antioxidants exerts potential skin antiaging effects.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 171001
[Lr] Last revision date:171001
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.5114/ada.2017.69314

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[PMID]: 28948013
[Au] Autor:Okello J; Okullo JBL; Eilu G; Nyeko P; Obua J
[Ad] Address:School of ForestryEnvironmental and Geographical SciencesCollege of Agricultural and Environmental SciencesMakerere UniversityKampalaUganda.
[Ti] Title:Mineral composition of LINN (tamarind) pulp and seeds from different agro-ecological zones of Uganda.
[So] Source:Food Sci Nutr;5(5):959-966, 2017 Sep.
[Is] ISSN:2048-7177
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Mineral composition of dry LINN pulp and seeds was evaluated on samples collected from three different agro-ecological zones of Uganda (Lake Victoria Crescent, and Eastern and West Nile). The objective of the study was to evaluate the mineral composition of pulp and seed samples from across Uganda's different agro-ecological zones and land use types. Separately grounded samples of pulp and seeds were analyzed for Zn, Fe, Mg, P, Na, K, and Ca. The univariate analysis of variance in the General Linear Model was used to compare differences in mineral composition. Treatment means were separated using Least Significant Difference (LSD) in Post Hoc Tests. The results showed that there were significant differences ( ≤ 0.005) in mineral composition levels of pulp and seed samples between the different agro-ecological zones with the exception of P and Na (for pulp). The pulp and seeds samples from the Lake Victoria Crescent zone and wild land use type had generally higher mineral levels than samples from other agro-ecological zones and different land use types. As mineral composition levels were generally higher in the seed than the pulp samples, consumption of seeds should be promoted. There is also need to conserve individual species both on-farm and in the wild population, but mineral concentrations (both pulp and seeds) were higher in the samples from the wild population, making them good for human and animal diets.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1709
[Cu] Class update date: 171001
[Lr] Last revision date:171001
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1002/fsn3.490

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[PMID]: 28940510
[Au] Autor:D'souza C; Fernandes R; Kudale S; Naik AS
[Ad] Address:Food Science & Technology Section, School of Biotechnology & Bioinformatics, D.Y. Patil University, Belapur, Navi Mumbai, Maharashtra, India.
[Ti] Title:Local indigenous fruit-derived juices as alternate source of acidity regulators.
[So] Source:J Sci Food Agric;, 2017 Sep 20.
[Is] ISSN:1097-0010
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Acidity regulators are additives that alter and control food acidity. The objective of this study was to explore local indigenous fruits as sources of natural acidity regulators. Juices extracted from Garcinia indica (kokum), Embilica officinalis (amla) and Tamarindus indica (tamarind) were used as acidulants for media such as coconut milk and bottle gourd juice. The buffering capacity ß, acid composition, antioxidant activity and shelf-life study of the acidified media were estimated. RESULTS: Potentiometric titration showed G. indica to possess the highest buffering capacity in both ranges. High-performance liquid chromatography analysis showed T. indica contained a high level of tartaric acid (4.84 ± 0.01 mg g ), while G. indica had citric acid (22.37 ± 0.84 mg g ) and E. officinalis had citric acid (2.75 ± 0.02 mg g ) along with ascorbic acid (2.68 ± 0.01 mg g ). 1,1-Diphenyl-2-picrylhydrazyl scavenging activity was high for E. officinalis (91.24 ± 0.66%) and T. indica (90.93 ± 0.817%) and relatively lower for G. indica (34.61 ± 3.66%). The shelf-life study showed total plate count to be within the prescribed limits up to a week, in accordance with safety regulations. CONCLUSION: This investigation confirmed the suitability of indigenous fruit juices as alternatives to existing acidity regulators. © 2017 Society of Chemical Industry.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 171023
[Lr] Last revision date:171023
[St] Status:Publisher
[do] DOI:10.1002/jsfa.8684

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[PMID]: 28928066
[Au] Autor:Alpizar-Reyes E; Román-Guerrero A; Gallardo-Rivera R; Varela-Guerrero V; Cruz-Olivares J; Pérez-Alonso C
[Ad] Address:Departamento de Ingeniería Química, Facultad de Química, Universidad Autónoma del Estado de México, Paseo Colón esq. Paseo Tollocan s/n, Col. Residencial Colón, C.P. 50120, Toluca, Estado de México, Mexico.
[Ti] Title:Rheological properties of tamarind (Tamarindus indica L.) seed mucilage obtained by spray-drying as a novel source of hydrocolloid.
[So] Source:Int J Biol Macromol;, 2017 Sep 18.
[Is] ISSN:1879-0003
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Tamarind seed mucilage (TSM) was extracted and obtained by spray drying. The power law model well described the rheological behavior of the TSM dispersions with determination coefficients R higher than 0.93. According to power law model, non-Newtonian shear thinning behavior was observed at all concentrations (0.5%, 1%, 1.5% and 2%) and temperatures (25, 30, 40, and 60°C) studied. Increasing temperature decreased the viscosity and increased the flow behavior index, opposite effect was observed when increasing the concentration. The temperature effect was more pronounced at 2.0% TSM concentration with an activation energy of 20.25kJ/mol. A clear dependence of viscosity on pH was observed, as pH increased from acidic to alkaline conditions, the viscosity increased. It was found that the rheological properties of TSM were affected by the sucrose and salts and their concentrations as well due to the addition of ions (or sucrose) decreases repulsion and allows molecule expansion promoting a significant reduction in viscosity. These results suggest that TMS could be applied in the production of foods that require additives with thickening capacity.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 171003
[Lr] Last revision date:171003
[St] Status:Publisher

  9 / 350 MEDLINE  
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[PMID]: 28888089
[Au] Autor:Bhadoriya SS; Ganeshpurkar A; Bhadoriya RPS; Sahu SK; Patel JR
[Ad] Address:.
[Ti] Title:Antidiabetic potential of polyphenolic-rich fraction of Tamarindus indica seed coat in alloxan-induced diabetic rats.
[So] Source:J Basic Clin Physiol Pharmacol;, 2017 Sep 09.
[Is] ISSN:2191-0286
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:BACKGROUND: Tamarindus is a monotypic genus and belongs to the subfamily Caesalpinioideae of the family Leguminosae (Fabaceae), Tamarindus indica L., commonly known as Tamarind tree is one of the most important multipurpose tropical fruit tree species in the India, Sudan, Nigeria, Bangladesh and entire subcontinent. METHODS: Hydroethanolic seed coat extract of Tamarindus indica (HETI) was assessed for presence of phytoconstituents and selection of optimum dose through acute and sub acute toxicity study. The single and multidose (14 days) study were conducted to evaluate antidiabetic potential of HETI in alloxan induced rats via determine of blood glucose level, body weight, hematological profile, extra-pancreatic glucose utilization of isolated rat hemi-diaphragm as well as histopathology of rat pancreas. RESULTS: Phytochemical analysis of HETI showed the presence of polyphenol like flavonoids. Single and multidose of HETI significantly (p<0.05; p<0.001) reduced blood glucose level in normoglycaemic, glucose loaded and alloxan induced hyperglycaemic animals. HETI exerts the protective effect on pancreatic ß-cells as per results obtained from histopathology of animals. Moreover, HETI increased glucose uptake in isolated rat hemi-diaphragm and prevents decrease in body weight along with recovery of altered hematological parameters. CONCLUSIONS: The study revealed that HETI have potent hypoglycaemic action by virtue of its Phytoconstituents and it can be used as a herbal medicine for diabetes.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170911
[Lr] Last revision date:170911
[St] Status:Publisher

  10 / 350 MEDLINE  
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[PMID]: 28880962
[Au] Autor:Gaisberger H; Kindt R; Loo J; Schmidt M; Bognounou F; Da SS; Diallo OB; Ganaba S; Gnoumou A; Lompo D; Lykke AM; Mbayngone E; Nacoulma BMI; Ouedraogo M; Ouédraogo O; Parkouda C; Porembski S; Savadogo P; Thiombiano A; Zerbo G; Vinceti B
[Ad] Address:Bioversity International, Via dei Tre Denari 472/a, Maccarese (Rome), Italy.
[Ti] Title:Spatially explicit multi-threat assessment of food tree species in Burkina Faso: A fine-scale approach.
[So] Source:PLoS One;12(9):e0184457, 2017.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Over the last decades agroforestry parklands in Burkina Faso have come under increasing demographic as well as climatic pressures, which are threatening indigenous tree species that contribute substantially to income generation and nutrition in rural households. Analyzing the threats as well as the species vulnerability to them is fundamental for priority setting in conservation planning. Guided by literature and local experts we selected 16 important food tree species (Acacia macrostachya, Acacia senegal, Adansonia digitata, Annona senegalensis, Balanites aegyptiaca, Bombax costatum, Boscia senegalensis, Detarium microcarpum, Lannea microcarpa, Parkia biglobosa, Sclerocarya birrea, Strychnos spinosa, Tamarindus indica, Vitellaria paradoxa, Ximenia americana, Ziziphus mauritiana) and six key threats to them (overexploitation, overgrazing, fire, cotton production, mining and climate change). We developed a species-specific and spatially explicit approach combining freely accessible datasets, species distribution models (SDMs), climate models and expert survey results to predict, at fine scale, where these threats are likely to have the greatest impact. We find that all species face serious threats throughout much of their distribution in Burkina Faso and that climate change is predicted to be the most prevalent threat in the long term, whereas overexploitation and cotton production are the most important short-term threats. Tree populations growing in areas designated as 'highly threatened' due to climate change should be used as seed sources for ex situ conservation and planting in areas where future climate is predicting suitable habitats. Assisted regeneration is suggested for populations in areas where suitable habitat under future climate conditions coincides with high threat levels due to short-term threats. In the case of Vitellaria paradoxa, we suggest collecting seed along the northern margins of its distribution and considering assisted regeneration in the central part where the current threat level is high due to overexploitation. In the same way, population-specific recommendations can be derived from the individual and combined threat maps of the other 15 food tree species. The approach can be easily transferred to other countries and can be used to analyze general and species specific threats at finer and more local as well as at broader (continental) scales in order to plan more selective and efficient conservation actions in time. The concept can be applied anywhere as long as appropriate spatial data are available as well as knowledgeable experts.
[Mh] MeSH terms primary: Conservation of Natural Resources/methods
Food
[Mh] MeSH terms secundary: Acacia
Adansonia
Anacardiaceae
Annona
Balanites
Bombax
Burkina Faso
Climate Change
Ecosystem
Olacaceae
Tamarindus
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171016
[Lr] Last revision date:171016
[Js] Journal subset:IM
[Da] Date of entry for processing:170908
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184457


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