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[PMID]: 29384234
[Au] Autor:Schilpzand EJ; Conroy R; Anderson V; Alisic E
[Ad] Address:Child Neuropsychology, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia.
[Ti] Title:Development and Evaluation of the Thinking About Recovery Scale: Measure of Parent Posttraumatic Cognitions Following Children's Exposure to Trauma.
[So] Source:J Trauma Stress;31(1):71-78, 2018 Feb.
[Is] ISSN:1573-6598
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Researchers have recently suggested that parent posttraumatic appraisals potentially contribute to the development of posttraumatic stress in both parents and children following children's exposure to trauma. However, a single-instrument, multidimensional measure of parent posttraumatic cognitions as they relate to their child's recovery has yet to be operationalized. This study described the development and evaluation of a parent-report questionnaire of parent posttraumatic cognitions, designed to be used after a child's exposure to trauma. We generated an initial pool of items in reference to existing theories and subjected this list to an iterative process of item writing and revision. Items were subjected to expert review to maximize construct validity. The 33-item Thinking About Recovery Scale (TARS), which measures three domains (My child has been permanently damaged; The world is dangerous for my child; Parents should always promote avoidance) demonstrated good internal consistency (Cronbach's α = .74-88) and convergent validity (r range = .08-.40) when piloted in a sample of 116 parents of children who had been exposed to a serious accidental injury. The TARS augments the available literature by providing a brief measure of parent posttraumatic cognitions, an area which is currently understudied in childhood posttraumatic stress and could have broad clinical and research use.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Data-Review
[do] DOI:10.1002/jts.22258

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[PMID]: 29409263
[Au] Autor:Usuelli FG; Indino C; Maccario C; Manzi L; Liuni FM; Vulcano E
[Ad] Address:IRCCS Istituto Ortopedico Galeazzi, Milan, Italy. Electronic address: fusuelli@gmail.com.
[Ti] Title:Infections in primary total ankle replacement: Anterior approach versus lateral transfibular approach.
[So] Source:Foot Ankle Surg;, 2017 Aug 04.
[Is] ISSN:1460-9584
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:BACKGROUND: Total ankle replacement (TAR) represents an alternative to fusion for the treatment of end-stage ankle osteoarthritis. The aim of the present study was to retrospectively assess the frequency of infections between TARs with anterior and lateral transfibular approach at 12-months follow-up. METHODS: 81 TARs through an anterior approach and 69 TARs through a lateral approach were performed between May 2011 and July 2015. We compared surgical time and tourniquet time, as well as superficial and deep infections frequency during the first 12 postoperative months. RESULTS: In the anterior approach group, there were 3 (3.7%) deep infections and 4 (4.9%) superficial wound infections. In the lateral approach group, there were 1 (1.4%) deep infection and 2 superficial wound infections (2.9%). There were not statistically significant differences between the groups. There was a significant difference between anterior approach (115minutes) and lateral approach group (179minutes) in terms of surgical time (P<0.001). CONCLUSIONS: The frequency of superficial and deep periprosthetic infections during the first postoperative year was not significantly different in the lateral approach group compared to the anterior approach group, despite the significantly longer surgical time in the lateral transfibular approach group.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180207
[Lr] Last revision date:180207
[St] Status:Publisher

  3 / 1646 MEDLINE  
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[PMID]: 29271607
[Au] Autor:Eckers F; Bauer DE; Hingsammer A; Sutter R; Brand B; Viehöfer A; Wirth SH
[Ad] Address:Orthopaedics, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
[Ti] Title:Mid- to long-term results of total ankle replacement in patients with haemophilic arthropathy: A 10-year follow-up.
[So] Source:Haemophilia;, 2017 Dec 22.
[Is] ISSN:1365-2516
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Haemophilic ankle arthropathy is caused by recurrent spontaneous joint haemorrhaging and leads to pain, deformity and loss of function. In the presence of advanced articular deterioration, therapeutic options are confined to either arthroplasty or arthrodesis, the latter still being referred to as the procedure of choice. However, total ankle replacement (TAR) has recently gained acceptance as an alternative. AIM: To investigate the mid- to long-term results of TAR in haemophilic ankle arthropathy. MATERIALS AND METHODS: Seventeen TARs in 14 male patients (mean age: 43 years [range, 27.4-57.6]), implanted between 1998 and 2012, were retrospectively analysed. Implant survival was estimated using Kaplan-Meier analysis. Haemophilic/viral status, complications and revision surgeries were recorded. Follow-up assessment of 12 TARs was performed 9.6 years (range, 3.3-17.8) postoperatively, including clinical examination, pain and satisfaction scales, the American Orthopaedic Foot and Ankle Society (AOFAS) hindfoot score, and the SF-36. Radiographic evaluation of pre- and follow-up radiographs was conducted. RESULTS: Estimated implant survival was 94% at 5, 85% at 10 and 70% at 15 years, respectively. Three cases required revision surgery. At follow-up, 9.6 years (range, 3.3-17.8) postoperatively, the level of satisfaction was 76% (range, 50-100) and of pain 2/10 (range, 0-6) on the VAS. Range of motion had increased significantly (P = .037). The SF-36 summary scores were comparable to those of a matched standard population. The AOFAS hindfoot score averaged 81 points (range, 73-90). All radiographs revealed component loosening or periprosthetic radiolucency. CONCLUSION: Total ankle replacement in the presence of advanced haemophilic arthropathy is a viable treatment option with favourable mid-/long-term results, maintaining mobility of the ankle joint.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171222
[Lr] Last revision date:171222
[St] Status:Publisher
[do] DOI:10.1111/hae.13386

  4 / 1646 MEDLINE  
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[PMID]: 29153904
[Au] Autor:Joly FX; Coulis M
[Ad] Address:CEFE UMR 5175, CNRS - Université de Montpellier - Université Paul-Valéry Montpellier - EPHE, 1919 Route de Mende, FR-34293 Montpellier Cedex 5, France. Electronic address: francois-xavier.joly@stir.ac.uk.
[Ti] Title:Comparison of cellulose vs. plastic cigarette filter decomposition under distinct disposal environments.
[So] Source:Waste Manag;, 2017 Nov 15.
[Is] ISSN:1879-2456
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:It is estimated that 4.5 trillion cigarette butts are discarded annually, making them numerically the most common type of litter on Earth. To accelerate their disappearance after disposal, a new type of cigarette filters made of cellulose, a readily biodegradable compound, has been introduced in the market. Yet, the advantage of these cellulose filters over the conventional plastic ones (cellulose acetate) for decomposition, remains unknown. Here, we compared the decomposition of cellulose and plastic cigarettes filters, either intact or smoked, on the soil surface or within a composting bin over a six-month field decomposition experiment. Within the compost, cellulose filters decomposed faster than plastic filters, but this advantage was strongly reduced when filters had been used for smoking. This indicates that the accumulation of tars and other chemicals during filter use can strongly affect its subsequent decomposition. Strikingly, on the soil surface, we observed no difference in mass loss between cellulose and plastic filters throughout the incubation. Using a first order kinetic model for mass loss of for used filters over the short period of our experiment, we estimated that conventional plastic filters take 7.5-14 years to disappear, in the compost and on the soil surface, respectively. In contrast, we estimated that cellulose filters take 2.3-13 years to disappear, in the compost and on the soil surface, respectively. Our data clearly showed that disposal environments and the use of cellulose filters must be considered when assessing their advantage over plastic filters. In light of our results, we advocate that the shift to cellulose filters should not exempt users from disposing their waste in appropriate collection systems.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171120
[Lr] Last revision date:171120
[St] Status:Publisher

  5 / 1646 MEDLINE  
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[PMID]: 29148719
[Au] Autor:Zhang Y; Wang X; Perner S; Bánkfalvi Á; Schlücker S
[Ti] Title:Effect of antigen retrieval methods on non-specific binding of anti-body-metal nanoparticle conjugates on FFPE tissue.
[So] Source:Anal Chem;, 2017 Nov 17.
[Is] ISSN:1520-6882
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Immunohistochemical analysis of FFPE tissues provides important diagnostic and prognostic information in pathology. Metal nanoparticles (NPs) and in particular surface-enhanced Raman scattering (SERS) nanotags as a new class of labelling reagents are promising to be used for multiplexed protein profiling on tissue sections. However, non-specific binding of NPs onto the tissue specimens greatly hampers their clinical applications. In this study, we found that the antigen retrieval method strongly influences the extent of non-specific binding of the antibody-SERS NP conjugates to the tissue. Our SERS labels comprise either Au nanos-tars or Au/Ag nanoshells coated with ethylene glycol-modified Raman reporter molecules for hydrophilic stabilization and subse-quent covalent bioconjugation to primary/secondary antibodies. We systematically investigated the influence of heat- and prote-ase-induced epitope retrieval (HIER/PIER) on the immuno-staining quality of prostate-specific antigen (PSA) on human prostate tissue sections. Pretreatment of the tissue sections by HIER led to selective but non-specific adsorption of the antibody-Au nanos-tar conjugates onto epithelial cells, while enzymatic treatment did not. Metal NPs with different sizes/shapes (incl. ca. 20 nm Au NPs and ca. 60 nm Au/Ag nanoshells) and tissue sections from different origins (incl. prostate and breast tissue) were then tested; in each case the same tendency was observed. Therefore, PIER is recommended for future NP-based tissue immuno-staining such as immuno-SERS microscopy. Alternatively, for antigens which can only be unmasked by heating, PEGylation of the NPs is nec-essary to avoid non-specific binding.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171117
[Lr] Last revision date:171117
[St] Status:Publisher
[do] DOI:10.1021/acs.analchem.7b03144

  6 / 1646 MEDLINE  
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[PMID]: 29088033
[Au] Autor:Benich MR; Ledoux WR; Orendurff MS; Shofer JB; Hansen ST; Davitt J; Anderson JG; Bohay D; Coetzee JC; Maskill J; Brage M; Houghton M; Sangeorzan BJ
[Ad] Address:1VA Puget Sound Health Care System, Seattle, Washington 2Harborview Medical Center, University of Washington, Seattle, Washington 3Orthopedic + Fracture Specialists, Portland, Oregon 4Orthopaedic Associates of Michigan, Grand Rapids, Michigan 5Twin Cities Orthopedics, Edina, Minnesota 6Orthopaedic & Spine Center of the Rockies, Fort Collins, Colorado.
[Ti] Title:Comparison of Treatment Outcomes of Arthrodesis and Two Generations of Ankle Replacement Implants.
[So] Source:J Bone Joint Surg Am;99(21):1792-1800, 2017 Nov 01.
[Is] ISSN:1535-1386
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: We analyzed self-reported outcomes in a prospective cohort of patients treated with ankle arthrodesis or total ankle replacement (TAR) during a time of transition from older to newer-generation TAR implants. METHODS: We performed a prospective cohort study comparing outcomes in 273 consecutive patients treated for ankle arthritis with arthrodesis or TAR between 2005 and 2011. Adult patients with end-stage ankle arthritis who were able to walk and willing and able to respond to surveys were included in the study. Patients were excluded when they had another lower-limb problem that might affect walking. At baseline and at 6, 12, 24, and 36-month follow-up visits, participants completed a pain score, a Musculoskeletal Function Assessment (MFA), and a Short Form-36 (SF-36) survey. RESULTS: There was significant mean improvement in most outcomes after surgery regardless of procedure. In general, the greatest improvement occurred during the first 6 months of follow-up. Linear mixed-effects regression adjusted for differences at baseline in age, body mass index (BMI), and surgery type showed that at 6 months the scores were improved by a mean (and standard error) of 12.6 ± 0.7 (33%) on the MFA, 22.0 ± 1.4 (56%) on the SF-36 Physical Functioning (PF) scale, 32.4 ± 1.6 (93%) on the SF-36 Bodily Pain (BP) scale, and 4.0 ± 0.2 (63%) on the pain rating scale. The mean improvements in the MFA and SF-36 PF scores over the 3-year follow-up period were significantly better after the TARs than after the arthrodeses, with differences between the 2 groups of 3.6 ± 1.6 (p = 0.023) and 7.5 ± 2.9 (p = 0.0098), respectively. The differences between the 2 groups were slightly greater when only the newer TAR devices were compared with the arthrodeses (MFA = 3.8 ± 1.8 [p = 0.031], SF-36 PF = 8.8 ± 3.3 [p = 0.0074], SF-36 BP = 7.3 ± 3.6 [p = 0.045], and pain score = 0.8 ± 0.4 [p = 0.038]). CONCLUSIONS: Patients reported improved comfort and function after both surgical treatments. The average improvement in the MFA and SF-36 PF scores was better after TAR than after arthrodesis, particularly when the TAR had been done with later-generation implants. Younger patients had greater functional improvements than older patients. LEVEL OF EVIDENCE: Therapeutic Level II. See Instructions for Authors for a complete description of levels of evidence.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171031
[Lr] Last revision date:171031
[St] Status:In-Process
[do] DOI:10.2106/JBJS.16.01471

  7 / 1646 MEDLINE  
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[PMID]: 28915423
[Au] Autor:Gamache D; Savard C; Lemelin S; Côté A; Villeneuve E
[Ad] Address:Université du Québec à Trois-Rivières, Département de psychologie, C.P. 500, Trois-Rivières, QC, Canada; CERVO Research Center, 2601 Chemin de la Canardière, Quebec City, QC, Canada. Electronic address: dominick.gamache@uqtr.ca.
[Ti] Title:Premature psychotherapy termination in an outpatient treatment program for personality disorders: a survival analysis.
[So] Source:Compr Psychiatry;80:14-23, 2017 Aug 09.
[Is] ISSN:1532-8384
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Psychological treatment for patients with personality disorders (PD) is plagued with a high proportion of early dropouts, and attempts to identify risk factors for attrition have generated very few conclusive results. The purpose of the present study is to identify significant predictors of early treatment termination in a long-term psychotherapy program for PD. METHODS: Data was retrospectively retrieved from 174 files of patients who began long-term psychotherapy in an outpatient treatment program in Quebec City, Canada. Socio-demographic, initial disturbance, and diagnostic variables were considered for prediction, along with a measure specifically designed to identify PD patients at risk of dropping out early from psychotherapy, the Treatment Attrition-Retention Scale for Personality Disorders (TARS-PD). Survival analysis using Cox proportional hazard regression was performed to identify significant predictors. RESULTS: Results using univariate Cox proportional hazards regressions revealed that unemployment, Global Assessment of Functioning scores, and recent hetero-aggressive behavior were significant predictors of early dropout in the first six months of therapy. Adjusting for these three confounders, four of the factor scores from the TARS-PD (Narcissism, Secondary gains, Low distress, and Cluster A features) were significantly associated with dropout in univariate Cox proportional hazards regressions. Secondary gains and Narcissism remained significant predictors after entering all five TARS-PD factors in a multivariate Cox proportional hazards regression adjusting for confounders. CONCLUSIONS: Taking into consideration specific treatment prognosis variables, such as those measured by the TARS-PD, might be more useful for dropout prediction in PD patients in comparison with more general demographic and diagnostic variables.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170915
[Lr] Last revision date:170915
[St] Status:Publisher

  8 / 1646 MEDLINE  
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[PMID]: 28871360
[Au] Autor:Di Iorio A; Viste A; Fessy MH; Besse JL
[Ad] Address:Centre Hospitalier Universitaire de Lyon, Service de Chirurgie Orthopédique et Traumatologique, Centre Hospitalier Lyon-Sud, FR 69495, Pierre-Bénite, Rhône-Alpes, France. alex.diiorio@gmail.com.
[Ti] Title:The AES total ankle arthroplasty analysis of failures and survivorship at ten years.
[So] Source:Int Orthop;41(12):2525-2533, 2017 Dec.
[Is] ISSN:1432-5195
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:BACKGROUND: AES mobile-bearing total ankle replacement was developed from the Buechel Pappas model. It was withdrawn in 2009, after identification of a higher than expected complication rate. The purpose of the current study was to analyse clinical outcomes, failures and survival of the initial series of 50 AES published in 2009. METHODS: In this single-centre continuous prospective study (2003-2006), 50 AES prostheses were included. Pre-operative osteoarthritis was mainly post-traumatic (50%) and secondary to instability (36%). All patients were assessed with clinical and radiographic follow-up at six months, one year, two years and every two to three years thereafter. A CT-scan was systematically performed before procedure, and at two years, five years and ten years. At last follow-up, all patients with TAR had a functional (SF 36, AOFAS) and clinical assessment. All complications or surgical events were analysed. RESULTS: The mean follow-up was ten ± two years (range, 9-13). The mean AOFAS score was 75 points (range, 26-100). The mean SF 36 score was 69 points (range, 35-97). There was a significant deterioration in AOFAS score at five years and at last follow-up (p < 0.05). Fifteen TARs underwent reoperation for cyst curettage-graft because of development of periprosthetic lesions. Six of them ended up with prosthesis removal-arthrodesis. At the last follow-up, 14 TARs were removed for arthrodesis. Of the 30 prostheses seen at last follow-up, four are awaiting prosthesis removal-arthrodesis and one for cyst curettage-graft. The ten year survivorships free of any prosthesis removal or arthrodesis and free of any reoperation were 68% (95% CI, 55-85) and 57% (95% CI, 44-74), respectively. CONCLUSION: Our data suggested a high rate of reoperation. Overall ten year survival was lower than with other designs, particularly due to cyst lesions. LEVEL OF EVIDENCE: Level IV, prospective case series.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 171113
[Lr] Last revision date:171113
[St] Status:In-Process
[do] DOI:10.1007/s00264-017-3605-0

  9 / 1646 MEDLINE  
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[PMID]: 28690307
[Au] Autor:Osuga A; Uematsu Y; Yamajima Y; Fujiwara T; Tahara S; Miyakawa H; Monma K
[Ad] Address:Tokyo Metropolitan Institute of Public Health.
[Ti] Title:Analyses of Acidic Tar Dyes in High-Protein Foods and Examination of Extraction and Clean-Up Methods for Various Foods.
[So] Source:Shokuhin Eiseigaku Zasshi;58(3):160-165, 2017.
[Is] ISSN:1882-1006
[Cp] Country of publication:Japan
[La] Language:jpn
[Ab] Abstract:Extraction and clean-up methods were examined for the analysis of acidic tar dyes in various high-protein foods. 1% Aqueous ammonia followed by ethanol, 1% aqueous ammonia-ethanol (1 : 1) mixture, and 1% aqueous ammonia-tetrahydrofuran (1 : 1) mixture were used in sequence for boiled fish paste (kamaboko), pounded fish cake (hanpen), and sausage. The sausage extract was centrifuged at low temperature to solidify and remove the contained fat. Salted cod roe with red pepper was extracted twice with 1% aqueous ammonia-ethanol (1 : 1) mixture, followed by extraction with 1% aqueous ammonia-tetrahydrofuran (1 : 1) mixture. A divinylbenzene-N-vinylpyrrolidone copolymer column was used for the clean-up of xanthen dyes. In the case of clogging-prone samples, the same type of large-particle-size column was used. A polyamide column was used for clean-up of the other dyes. When each dye was added at 5 µg/g in the foods, recoveries from kamaboko, hanpen, and sausage ranged from 76 to 102%, and the average recovery from the two types of salted cold roe with red pepper ranged from 45 to 98%.
[Mh] MeSH terms primary: Fish Products/analysis
Food Analysis/methods
Food Coloring Agents/analysis
Food Coloring Agents/isolation & purification
Tars/analysis
Tars/isolation & purification
Xanthenes/analysis
Xanthenes/isolation & purification
[Mh] MeSH terms secundary: Hydrogen-Ion Concentration
Polyvinyls
Solid Phase Extraction/methods
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Food Coloring Agents); 0 (Polyvinyls); 0 (Tars); 0 (Xanthenes); 0 (divinylbenzene-N-vinylpyrrolidone copolymer)
[Em] Entry month:1709
[Cu] Class update date: 171017
[Lr] Last revision date:171017
[Js] Journal subset:IM
[Da] Date of entry for processing:170711
[St] Status:MEDLINE
[do] DOI:10.3358/shokueishi.58.160

  10 / 1646 MEDLINE  
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[PMID]: 28647514
[Au] Autor:Begum AN; Aguilar JS; Hong Y
[Ad] Address:College of Veterinary Medicine, Western University of Health Sciences, Pomona, CA 91766-1854, USA.
[Ti] Title:Aqueous cigarette tar extracts disrupt corticogenesis from human embryonic stem cells in vitro.
[So] Source:Environ Res;158:194-202, 2017 10.
[Is] ISSN:1096-0953
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:BACKGROUND: Cigarette butts are the most common form of litter in the world, and approximately 4.5 trillion smoked cigarettes are discarded every year worldwide. Cigarette butts contain over 4000 chemicals, many of which are known to have neurotoxic effects. Stem cell neuronal differentiation provides an excellent cellular model with which to examine the impact of aqueous cigarette tar extracts (ACTEs) on neurodevelopment. METHODS: We have developed a neurosphere-based stem cell neuronal differentiation protocol that can recapitulate corticogenesis and produce cell types that are similar to upper and lower layer cortical projection neurons found in the germinal zone of the developing human cortex. In this study, ACTEs were generated from smoked cigarette butts and then applied at different concentrations to neuronal progenitors and cortical neurons derived from human embryonic stem cells. RESULTS: ACTEs reduced the expression of the cortical neuronal progenitor markers pax6, tbr2, and neuroD and decreased the number of cortical layer neurons (tbr1, satb2, foxp2, and brn2) after exposure to as low as 1.87% of the extract from one smoked cigarette butt. Furthermore, our results showed that ACTEs increased reactive oxygen species (ROS) production in cortical neurons, which caused a substantial loss of the synaptic proteins PSD95, synaptophysin, vesicular glutamate transporter1 (vGlut1), and the extracellular matrix molecule reelin; all of those molecules are important for the maintenance of cortical neuron identity and activity. CONCLUSION: ACTEs from smoked cigarettes have significant effects on cortical neuron development and neurodegeneration. The stem cell neuronal differentiation model holds great promise as a potentially powerful tool for the assessment of ACTEs on neurotoxicity.
[Mh] MeSH terms primary: Cell Differentiation/drug effects
Cerebral Cortex/drug effects
Human Embryonic Stem Cells/drug effects
Neurons/drug effects
Tars/toxicity
[Mh] MeSH terms secundary: Cerebral Cortex/physiology
Human Embryonic Stem Cells/physiology
Humans
Neurons/physiology
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Name of substance:0 (Tars); 0 (tobacco tar)
[Em] Entry month:1708
[Cu] Class update date: 171120
[Lr] Last revision date:171120
[Js] Journal subset:IM
[Da] Date of entry for processing:170626
[St] Status:MEDLINE


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