Database : MEDLINE
Search on : Teratogenesis [Words]
References found : 2664 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 267 go to page                         

  1 / 2664 MEDLINE  
              next record last record
select
to print
Photocopy
Full text

[PMID]: 29452148
[Au] Autor:Green BT; Lee ST; Keele JW; Welch KD; Cook D; Pfister JA; Kem WR
[Ad] Address:USDA-ARS Poisonous Plant Research Laboratory, Logan, UT 84341, USA. Electronic address: Ben.Green@ars.usda.gov.
[Ti] Title:Complete inhibition of fetal movement in the day 40 pregnant goat model by the piperidine alkaloid anabasine but not related alkaloids.
[So] Source:Toxicon;144:61-67, 2018 Mar 15.
[Is] ISSN:1879-3150
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Four chemically similar alkaloids, anabasine, anabaseine, epibatidine and dimethylphenylpiperazinium (DMPP), are potent nicotinic acetylcholine receptor agonists of fetal muscle nicotinic acetylcholine receptors in human TE-671 cells. Based on results with these cells, we hypothesized that the alkaloids would completely inhibit ultrasound-monitored fetal movement in a goat model. Different, single doses of anabasine, anabaseine, epibatidine, DMPP, or saline control were administered I.V. to pregnant goats on day 40 of gestation and the number of fetal movements per 5 min sample was measured by ultrasound at times 0, 0.5, 1, 2, 4 and 8 h. The differences among does in fetal movements were more consistent at dosing and following recovery for doses of anabasine above 0.125 mg/kg compared to the other compounds and dosages. Anabasine actions were dose-dependent with an IC value of ∼0.1 mg/kg, and, at a dose of 0.8 mg/kg, completely inhibited fetal movement for 1.5 h after dosing. Anabaseine, epibatidine, and DMPP failed to completely inhibit fetal movement in day 40 pregnant goats at doses predicted to be effective. These results suggest that while experiments with TE-671 cells provide valuable information and predictions of the actions of plant alkaloids on fetal movement, invivo experiments are still required in order to determine the ability of an alkaloid to inhibit fetal movement in livestock species. Moreover, other pharmacological properties such as receptor differences between mammalian species and differences in the pharmacokinetic properties of the alkaloids also are likely to weaken teratologic predictions based solely on the invitro data.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:In-Process

  2 / 2664 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29408581
[Au] Autor:Ishikawa RB; Vani JM; das Neves SC; Rabacow APM; Kassuya CAL; Croda J; Cardoso CAL; Monreal ACDF; Antoniolli ACMB; Cunha-Laura AL; Oliveira RJ
[Ad] Address:Centro de Estudos em Clulas Tronco, Terapia Celular e Gentica Toxicolgica (CeTroGen), Hospital Universitrio Maria Aparecida Pedrossian (HUMAP), Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, Mato Grosso do Sul, Brazil; Programa de Mestrado em Farmcia, Faculdade de Cincias Far
[Ti] Title:The safe use of Doliocarpus dentatus in the gestational period: Absence of changes in maternal reproductive performance, embryo-fetal development and DNA integrity.
[So] Source:J Ethnopharmacol;217:1-6, 2018 Jan 31.
[Is] ISSN:1872-7573
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:ETHNOPHARMACOLOGICAL RELEVANCE: Doliocarpus dentatus (Dilleniaceae) is commonly used in Brazil for the treatment of inflammatory process pain and urinary retention. Previous studies of our group have demonstrated the anti-inflammatory and antimycobacterial action of the ethanolic extract of Doliocarpus dentatus (EEDd) as well as the safety of its use. AIM OF THE STUDY: we investigated the effects of EEDd on reproductive performance, fetal development and DNA integrity in pregnant female Swiss mice. MATERIAL AND METHODS: thirty female Swiss mice were divided into three experimental groups (n = 10): control group treated with 1% tween-80 and EEDd1 and EEDd2 groups treated with EEDd at doses of 100 and 1000 mg/kg, respectively. The treatment occurred by oral gavage throughout the gestational period. At the end of pregnancy, parameters related to reproductive performance, embryofoetal development and DNA integrity was evaluated. RESULTS: both doses of the extract tested did not alter the reproductive parameters, did not present significant differences in the embryofetal development when compared to the control group and also did not induce the formation of micronuclei. CONCLUSION: the EEDd do not alter the reproductive parameters, embryofetal development and DNA integrity, ensuring its safe use during pregnancy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180303
[Lr] Last revision date:180303
[St] Status:Publisher

  3 / 2664 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Clinical Trials Registry
Clinical Trials Registry
Clinical Trials Registry
Clinical Trials Registry
Clinical Trials Registry
Clinical Trials Registry
Full text

[PMID]: 29455499
[Au] Autor:Zhang C; Zhang ZJ; Wang L; Chang ZX; Yang LP; Zhao M; Li XX; Feng RP; Wang GJ; Duan XB
[Ti] Title:[Lateral closing wedge osteotomy and modified cross pinning with external tension band fixation in the treatment of cubitus varus deformity in childrenLateral closing wedge osteotomy and modified cross pinning with external tension band fixation in the treatment of cubitus varus deformity in children].
[So] Source:Zhongguo Gu Shang;30(8):707-710, 2017 Aug 25.
[Is] ISSN:1003-0034
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To explore the therapeutic effects of distal humeral lateral closing wedge osteotomy followed by modified pinning combined with external tension band fixation in the treatment of cubitus varus deformity in children. METHODS: Total 26 adult patients with cubitus varus deformity were treated by operation from March 2011 to June 2015, 15 patients were boys and the other 11 patients were girls, ranging in age from 4 to 13 years, with an average of 7.8 years. The cubitus varus angel ranged from 11 degrees to 24 degrees, with a mean(17.506.73) degrees, 3 patients complicated more than 10 degrees constriction of flexion. Lateral closing wedge osteotomy retaining the medial 3 to 4 mm intact cortex by lateral elbow approach was applied in these 26 patients. The wedge defect were closed and fixed by crossing pinning. The lateral column compression was achieved with external tension band(the crossing pins were bended laterally and the pin ends were hooked mutually). The pre-operative, post-oparetive and contralateral carrying angles were compared and Laupattarakasem criteria was used to evaluate the results at follow-up. RESULTS: All the patients got bony union 2 months after operation and there was no infection or nerve palsy. The average follow-up period was 18.8 months (ranged, 13 to 29 months). The carrying angle was restored to(11.503.17) degrees(ranged, 8 to 14 degrees). According to the Laupattarakasem evaluation criteria, 14 patients got an excellent result, 13 good and 1 fair. CONCLUSIONS: Normal carrying angle and elbow flexion could be restored by lateral closing wedge osteotomy, and stable fixation could be achieved with crossing pinning and external tension band, which is available for early mobilization.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180218
[Lr] Last revision date:180218
[Cl] Clinical Trial:ClinicalTrial
[St] Status:In-Process
[do] DOI:10.3969/j.issn.1003-0034.2017.08.005

  4 / 2664 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29306033
[Au] Autor:Bonfanti P; Saibene M; Bacchetta R; Mantecca P; Colombo A
[Ad] Address:Department of Earth and Environmental Sciences, Research Centre POLARIS, University of Milano-Bicocca, 1, Piazza della Scienza, 20126 Milan, Italy. Electronic address: patrizia.bonfanti@unimib.it.
[Ti] Title:A glyphosate micro-emulsion formulation displays teratogenicity in Xenopus laevis.
[So] Source:Aquat Toxicol;195:103-113, 2018 Feb.
[Is] ISSN:1879-1514
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Glyphosate is the active ingredient in broad-spectrum herbicide formulations used in agriculture, domestic area and aquatic weed control worldwide. Its market is growing steadily concurrently with the cultivation of glyphosate-tolerant transgenic crops and emergence of weeds less sensitive to glyphosate. Ephemeral and lentic waters near to agricultural lands, representing favorite habitats for amphibian reproduction and early life-stage development, may thus be contaminated by glyphosate based herbicides (GBHs) residues. Previous studies on larval anuran species highlighted increased mortality and growth effects after exposure to different GBHs in comparison to glyphosate itself, mainly because of the surfactants such as polyethoxylated tallow amine present in the formulations. Nevertheless, these conclusions are not completely fulfilled when the early development, characterized by primary organogenesis events, is considered. In this study, we compare the embryotoxicity of Roundup Power 2.0, a new GBH formulation currently authorized in Italy, with that of technical grade glyphosate using the Frog Embryo Teratogenesis Assay-Xenopus (FETAX). Our results evidenced that glyphosate was not embryolethal and only at the highest concentration (50 mg a.e./L) caused edemas. Conversely, Roundup Power 2.0 exhibited a 96 h LC50 of 24.78 mg a.e./L and a 96 h EC50 of 7.8 mg a.e./L. A Teratogenic Index of 3.4 was derived, pointing out the high teratogenic potential of the Roundup Power 2.0. Specific concentration-dependent abnormal phenotypes, such as craniofacial alterations, microphthalmia, narrow eyes and forebrain regionalization defects were evidenced by gross malformation screening and histopathological analysis. These phenotypes are coherent with those evidenced in Xenopus laevis embryos injected with glyphosate, allowing us to hypothesize that the teratogenicity observed for Roundup Power 2.0 may be related to the improved efficacy in delivering glyphosate to cells, guaranteed by the specific surfactant formulation. In conclusion, the differences in GBH formulations should be carefully considered by the authorities, since sub-lethal and/or long-term effects (e.g. teratogenicity) can be significantly modulated by the active ingredient salt type and concentration of the adjuvants. Finally, the mechanistic toxicity of glyphosate and GBHs are worthy of further research.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180206
[Lr] Last revision date:180206
[St] Status:In-Process

  5 / 2664 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29297239
[Ti] Title:Correction to: Singh, Sinha, and Sinnollareddy, Role of Apoptosis in Mediating Salicylic Acid-Induced Teratogenesis In Vitro.
[So] Source:Toxicol Mech Methods;:1, 2018 Jan 03.
[Is] ISSN:1537-6524
[Cp] Country of publication:England
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180103
[Lr] Last revision date:180103
[St] Status:Publisher
[do] DOI:10.1080/15376516.2017.1420052

  6 / 2664 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29193903
[Au] Autor:Gomes JDA; Kowalski TW; Fraga LR; Tovo-Rodrigues L; Sanseverino MTV; Schuler-Faccini L; Vianna FSL
[Ad] Address:Postgraduate Program in Genetics and Molecular Biology, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
[Ti] Title:Genetic susceptibility to thalidomide embryopathy in humans: Study of candidate development genes.
[So] Source:Birth Defects Res;, 2017 Nov 28.
[Is] ISSN:2472-1727
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Thalidomide is a drug used worldwide for several indications, but the molecular mechanisms of its teratogenic property are not fully understood. Studies in animal models suggest the oxidative stress, the inhibition of angiogenesis, and the binding to E3-ubiquitin ligase complex as mechanisms by which thalidomide can change the expression of genes important to embryonic development. In this study, seven polymorphisms in genes related to development (FGF8, FGF10, BMP4, SHH, TP53, TP63, and TP73) were analyzed in people with thalidomide embryopathy (TE) and compared to people without malformations. The sample consisted of 36 people with TE and 135 unrelated and nonsyndromic people who had their DNA genotyped by PCR real-time. Although no allelic or genotypic differences were observed between the groups, we hypothesized that other regions in these genes and related genes may play an important role in thalidomide teratogenesis, which is known to have a genetic contribution. Identifying such molecular mechanisms is essential for the development of a molecule that will be analogue to thalidomide but safe enough to avoid the emergence of new cases of TE.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171201
[Lr] Last revision date:171201
[St] Status:Publisher
[do] DOI:10.1002/bdr2.1163

  7 / 2664 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29172070
[Au] Autor:Barr KL
[Ad] Address:Department of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of Florida, United States. Electronic address: kellilbarr@ufl.edu.
[Ti] Title:Vertical transmission of positive-sense single-stranded RNA viruses in plants as a model for arboviral induced teratogenesis.
[So] Source:Curr Opin Virol;27:42-47, 2017 Nov 21.
[Is] ISSN:1879-6265
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Teratogenic viruses have increased public health importance with the emergence of Zika virus and a recent decline in rubella virus vaccination. Of the seven viruses known to cause birth defects in humans, three are mosquito-borne pathogens. Ethical oversight, compliance, rising costs, and the need for specialized training slow the pace of study of these human pathogens compared to study of similar teratogenic viruses in plants. Plant viruses have served as models for human viruses which can be applied to animal systems. This review describes the similar features of plant and animal teratogenic arboviruses and the common systems and barriers that are encountered during vertical transmission in the host.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1711
[Cu] Class update date: 171124
[Lr] Last revision date:171124
[St] Status:Publisher

  8 / 2664 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29121966
[Au] Autor:Smith TA; Kirkpatrick DR; Smith S; Smith TK; Pearson T; Kailasam A; Herrmann KZ; Schubert J; Agrawal DK
[Ad] Address:Department of Radiology, University of Utah, 30 North 1900 East #1A071, Salt Lake City, UT, 84132, USA.
[Ti] Title:Radioprotective agents to prevent cellular damage due to ionizing radiation.
[So] Source:J Transl Med;15(1):232, 2017 Nov 09.
[Is] ISSN:1479-5876
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Medical imaging has become a central component of patient care to ensure early and accurate diagnosis. Unfortunately, many imaging modalities use ionizing radiation to generate images. Ionizing radiation even in low doses can cause direct DNA damage and generate reactive oxygen species and free radicals, leading to DNA, protein, and lipid membrane damage. This cell damage can lead to apoptosis, necrosis, teratogenesis, or carcinogenesis. As many as 2% of cancers (and an associated 15,000 deaths annually) can be linked to computed tomography exposure alone. Radioprotective agents have been investigated using various models including cells, animals, and recently humans. The data suggest that radioprotective agents working through a variety of mechanisms have the potential to decrease free radical damage produced by ionizing radiation. Radioprotective agents may be useful as an adjunct to medical imaging to reduced patient morbidity and mortality due to ionizing radiation exposure. Some radioprotective agents can be found in high quantities in antioxidant rich foods, suggesting that a specific diet recommendation could be beneficial in radioprotection.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1711
[Cu] Class update date: 171119
[Lr] Last revision date:171119
[St] Status:In-Process
[do] DOI:10.1186/s12967-017-1338-x

  9 / 2664 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29109170
[Au] Autor:Dou X; Menkari C; Mitsuyama R; Foroud T; Wetherill L; Hammond P; Suttie M; Chen X; Chen SY; Charness ME; and the Collaborative Initiative on Fetal Alcohol Spectrum Disorders
[Ad] Address:Department of Neurology, Veterans Affairs Boston Healthcare System, Harvard Medical School, West Roxbury, Massachusetts, USA.
[Ti] Title:L1 coupling to ankyrin and the spectrin-actin cytoskeleton modulates ethanol inhibition of L1 adhesion and ethanol teratogenesis.
[So] Source:FASEB J;, 2017 Nov 06.
[Is] ISSN:1530-6860
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Ethanol causes fetal alcohol spectrum disorders (FASD) partly by inhibiting cell adhesion mediated by the L1 neural cell adhesion molecule. Ethanol interacts with an alcohol binding pocket in the L1 extracellular domain (ECD), and dephosphorylation of S1248 in the L1 cytoplasmic domain (CD) renders L1 adhesion insensitive to inhibition by ethanol (L1 insensitive). The mechanism underlying this inside-out signaling is unknown. Here we show that phosphorylation of the human L1-CD at S1152, Y1176, S1181, and S1248 renders L1 sensitive to ethanol by promoting L1 coupling with ankyrin-G and the spectrin-actin cytoskeleton. Knockdown of ankyrin-G or L1 mutations that uncouple L1 from ankyrin reduce L1 sensitivity to ethanol, but not methanol, consistent with a small conformational change in the extracellular alcohol binding pocket. Phosphorylation of Y1176 and ankyrin-G coupling with L1 are higher in NIH/3T3 clonal cell lines in which ethanol inhibits L1 adhesion than in ethanol-resistant NIH/3T3 clonal cell lines. Similarly, phosphorylation of Y1176 is higher in C57BL/6J mice that are sensitive to ethanol teratogenesis than in ethanol resistant C57BL/6N mice. Finally, polymorphisms in genes that encode ankyrin-G and p90rsk, a kinase that phosphorylates S1152, are linked to facial dysmorphology in children with heavy prenatal ethanol exposure. These findings indicate that genes that regulate L1 coupling to ankyrin may influence susceptibility to FASD.-Dou, X., Menkari, C., Mitsuyama, R., Foroud, T., Wetherill, L., Hammond, P., Suttie, M., Chen, X., Chen, S.-Y., Charness, M. E., Collaborative Initiative on Fetal Alcohol Spectrum Disorders. L1 coupling to ankyrin and the spectrin-actin cytoskeleton modulates ethanol inhibition of L1 adhesion and ethanol teratogenesis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171114
[Lr] Last revision date:171114
[St] Status:Publisher

  10 / 2664 MEDLINE  
              first record previous record
select
to print
Photocopy
Full text

[PMID]: 29104501
[Au] Autor:Mandal C; Halder D; Jung KH; Chai YG
[Ad] Address:Department of Molecular and Life Science, Hanyang University, Ansan, Republic of Korea.
[Ti] Title: Alcohol Exposure and the Alteration of Histone Marks in the Developing Fetus: An Epigenetic Phenomenon of Maternal Drinking.
[So] Source:Int J Biol Sci;13(9):1100-1108, 2017.
[Is] ISSN:1449-2288
[Cp] Country of publication:Australia
[La] Language:eng
[Ab] Abstract:Ethanol is well known for its teratogenic effects during fetal development. Maternal alcohol consumption allows the developing fetus to experience the detrimental effects of alcohol exposure. Alcohol-mediated teratogenic effects can vary based on the dosage and the length of exposure. The specific mechanism of action behind this teratogenic effect is still unknown. Previous reports demonstrated that alcohol participates in epigenetic alterations, especially histone modifications during fetal development. Additional research is necessary to understand the correlation between major epigenetic events and alcohol-mediated teratogenesis such as that observed in fetal alcohol spectrum disorder (FASD). Here, we attempted to collect all the available information concerning alcohol-mediated histone modifications during gestational fetal development. We hope that this review will aid researchers to further examine the issues associated with ethanol exposure.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1711
[Cu] Class update date: 171108
[Lr] Last revision date:171108
[St] Status:In-Process
[do] DOI:10.7150/ijbs.21047


page 1 of 267 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information