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[PMID]: 29514164
[Au] Autor:Safwan Ali Khan M; Khatoon N; Al-Sanea M; Gamal M; Rahman HU
[Ti] Title:Methanolic Extract of Leathery Murdah, Terminalia coriacea (Roxb.) Wight and Arn. Leaves Exhibits Anti-inflammatory Activity in Acute and Chronic Models.
[So] Source:Med Princ Pract;, 2018 Mar 07.
[Is] ISSN:1423-0151
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:OBJECTIVE: The aim of present study was to evaluate anti-inflammatory activity of methanolic extract of Terminalia coriacea. MATERIALS AND METHODS: A methanolic extract of Terminalia coriacea leaves was subjected to carrageenan-induced paw edema, an acute model, and cotton pellet-induced granuloma, a chronic model, at three oral test doses (125, 250 and 500 mg/kg) in albino Wistar rats. Aspirin 100 mg/kg was used as a positive control. Paw volume and wet and dry weights of cotton pellet were determined. The data was analyzed by one-way ANOVA followed by Dunnett's multiple comparison test. RESULTS: The test extract at doses of 125 and 250 mg/kg decreased paw volume, wet and dry weights of cotton pellets. The highest test dose (500 mg/kg) displayed comparable response to that of the standard drug (p < 0.01) on paw volume. The extract produced similar (p < 0.05) decrease in wet weight of the cotton pellet at 125 and 250 mg/kg whereas 500 mg/kg of the extract and aspirin 100 mg/kg produced comparable effect (p < 0.01). The extract of T. coriacea at 500 mg/kg produced most significant (p < 0.01) effect on wet weight of granulomatous tissue. CONCLUSION: The methanolic extract of Terminalia coriacea leaves successfully decreased paw edema as well as dry and wet weights of granulomatous tissue in both acute and chronic inflammatory models thus confirming the anti-edematogenic, anti-transudative and anti-proliferative properties of T. coriacea.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:Publisher
[do] DOI:10.1159/000488199

  2 / 1232 MEDLINE  
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[PMID]: 29501931
[Au] Autor:Kalem IK; Bhat ZF; Kumar S; Noor S; Desai A
[Ad] Address:College of Veterinary Pharmacy, Abhilashi University, Chail Chowk Mandi, Himachal Pradesh 175045, India.
[Ti] Title:The effects of bioactive edible film containing Terminalia arjuna on the stability of some quality attributes of chevon sausages.
[So] Source:Meat Sci;140:38-43, 2018 Feb 19.
[Is] ISSN:1873-4138
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The aim of this study was to assess the effectiveness of calcium alginate edible films incorporated with Terminalia arjuna on the lipid oxidative stability and storage quality of chevon sausages. Chevon sausages were aerobically packaged in the edible films containing different concentrations of T. arjuna viz. T (0.0%), T (0.50%) and T (1.0%) and were stored under refrigerated (4±1 °C) conditions. A significant improvement was observed in the lipid oxidative stability and microbial quality of the products. Products packaged in T and T films exhibited significantly (P < 0.05) lower values for TBARS (mg malonaldehyde/kg), microbial counts (log cfu/g) and FFA (% oleic acid). Higher (P < 0.05) sensory scores were also observed for the products packaged in T and T films. This study shows that application of a bioactive edible film incorporated with T. arjuna is an effective strategy in retarding the lipid oxidation and storage changes in meat products.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180304
[Lr] Last revision date:180304
[St] Status:Publisher

  3 / 1232 MEDLINE  
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[PMID]: 29235078
[Au] Autor:Zhong L; Bornman JF; Wu G; Hornoff A; Dovi KAP; Al-Ali H; Aslam N; Johnson SK
[Ad] Address:School of Public Health, Curtin University, Perth, Western Australia, 6102, Australia.
[Ti] Title:The Nutritional and Phytochemical Composition of the Indigenous Australian Pindan Walnut (Terminalia cunninghamii) Kernels.
[So] Source:Plant Foods Hum Nutr;73(1):40-46, 2018 Mar.
[Is] ISSN:1573-9104
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Nutritional composition of the kernels of two types of Pindan walnut (Terminalia cunninghamii), a native nut consumed traditionally by Australian Indigenous peoples, is reported for the first time. Results showed that Pindan walnut kernels contained high levels of fat, protein and ash, approximately 50, 30 and 5% fresh basis, respectively. The levels of minerals in the kernels were much higher than common walnuts and macadamia nuts, especially those of phosphorus, magnesium and zinc. The high amounts of polyphenols in the kernels provided strong hydrophilic antioxidant capacities, of up to 2004 mg Trolox equivalents/100 g fresh basis using the hydrophilic oxygen radical absorbance capacity assay. Both free polyphenol content and hydrophilic antioxidant capacities of the kernels were higher than those of macadamia nuts, although the lipophilic oxygen radical absorbance capacity was lower. These preliminary studies indicate high potential for wider use of the Pindan walnut as a novel, nutritious and health-promoting food.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:In-Process
[do] DOI:10.1007/s11130-017-0647-9

  4 / 1232 MEDLINE  
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[PMID]: 29248452
[Au] Autor:Kumar R; Arora R; Agarwal A; Gupta YK
[Ad] Address:Department of Pharmacology, All India Institutes of Medical Sciences, New Delhi, India.
[Ti] Title:Protective effect of Terminalia chebula against seizures, seizure-induced cognitive impairment and oxidative stress in experimental models of seizures in rats.
[So] Source:J Ethnopharmacol;215:124-131, 2018 Apr 06.
[Is] ISSN:1872-7573
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:ETHNOPHARMACOLOGICAL RELEVANCE: Teminalia chebula (TC) has been traditionally used in the Ayurvedic system of medicine primarily for gastrointestinal disorders. Its fruit extract has also been used to treat epilepsy and other CNS disorders. AIM OF THE STUDY: To evaluate the effect of hydroalcoholic fruit extract of Terminalia chebula (HETC) on experimental models of seizures, seizure-induced cognitive impairment and oxidative stress in rats. MATERIALS AND METHODS: In vitro antioxidant activity of HETC was evaluated by using ABTS, NO and DPPH radical scavenging assay. For in-vivo study, seizures were induced in Wistar rats (200-225g) by pentylenetetrazole (PTZ) and maximal-electroshock. (MES). The anticonvulsant effect of the HETC (250, 500, and 1000mg/kg, orally) was evaluated in seizure models. The therapeutic and sub-therapeutic dose of valproate and phenytoin were also assayed. The potential effect of co-administration of HETC (500mg/kg) with sub-therapeutic dose of valproate and phenytoin were also evaluated in PTZ and MES seizures model respectively. Effect on cognition was assessed using elevated plus maze (EPM) and passive avoidance test (PA). The in- vivo oxidative stress parameters (malondialdehyde and glutathione) were assessed in the cerebral cortex and hippocampus part of rat brain. RESULTS: The IC50 value of HETC in in vitro antioxidant assays i.e. ABTS, DPPH and NO radical scavenging assay was found to be 2.27µg/ml, 6.04µg/ml and 4.37µg/ml respectively. In experimental study, PTZ and MES treated groups exhibited 100% seizures with increased oxidative stress (p < 0.001) and cognitive deficits (p < 0.01) as compared to control group. HETC at highest dose (1000mg/kg) showed 83.33% (5/6) protection in MES induced seizures while 66.66% (4/6) protection in PTZ induced seizures. However, HETC (1000mg/kg) and co-administration of sub-therapeutic dose of HETC with valproate and phenytoin showed complete protection. In addition, it also attenuated the seizure induced oxidative stress and cognitive impairment as indicated by significant (p < 0.01) improvement in the transfer latencies in EPM and PA as compared to PTZ and MES treated group. CONCLUSIONS: The findings suggest that HETC exhibited significant anticonvulsant activity and also potentiated the subtherapeutic dose of phenytoin and valproate indicate its usefulness as an adjuvant to antiepileptic drugs with an advantage of preventing cognitive impairment and oxidative stress.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180215
[Lr] Last revision date:180215
[St] Status:In-Process

  5 / 1232 MEDLINE  
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[PMID]: 29402267
[Au] Autor:Haidara M; Haddad M; Denou A; Marti G; Bourgeade-Delmas S; Sanogo R; Bourdy G; Aubouy A
[Ad] Address:UMR 152 PHARMA-DEV, IRD, UPS, Université de Toulouse, Toulouse, France.
[Ti] Title:In vivo validation of anti-malarial activity of crude extracts of Terminalia macroptera, a Malian medicinal plant.
[So] Source:Malar J;17(1):68, 2018 Feb 05.
[Is] ISSN:1475-2875
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Plasmodium falciparum malaria is still one of the most deadly pathology worldwide. Efficient treatment is jeopardized by parasite resistance to artemisinin and its derivatives, and by poor access to treatment in endemic regions. Anti-malarial traditional remedies still offer new tracks for identifying promising antiplasmodial molecules, and a way to ensure that all people have access to care. The present study aims to validate the traditional use of Terminalia macroptera, a Malian plant used in traditional medicine. METHODS: Terminalia macroptera was collected in Mali. Leaves (TML) and roots ethanolic extracts (TMR) were prepared and tested at 2000 mg/kg for in vivo acute toxicity in Albino Swiss mice. Antiplasmodial activity of the extracts was assessed against a chloroquine resistant strain P. falciparum (FcB1) in vitro. In vivo, anti-malarial efficacy was assessed by a 4-day suppressive test at 100 mg/kg in two malaria murine models of uncomplicated malaria (Plasmodium chabaudi chabaudi infection) and cerebral malaria (Plasmodium berghei strain ANKA infection). Constituents of TMR were characterized by ultra-high-performance liquid chromatography coupled to high resolution mass spectrometry. Top ranked compounds were putatively identified using plant databases and in silico fragmentation pattern. RESULTS: Lethal dose of TML and TMR were greater than 2000 mg/kg in Albino Swiss mice. According to the OECD's Globally Harmonized System of Classification, both extracts are non-toxic orally. Antiplasmodial activity of T. macroptera extracts was confirmed in vitro against P. falciparum FcB1 strain with IC50 values of 1.2 and 1.6 µg/mL for TML and TMR, respectively. In vivo, oral administration of TML and TMR induced significant reduction of parasitaemia (37.2 and 46.4% respectively) in P. chabaudi chabaudi infected mice at the 7th day of infection compared to untreated mice. In the cerebral malaria experimental model, mice treated with TMR and TML presented respectively 50 and 66.7% survival rates at day 9 post-infection when all untreated mice died. Eleven major compounds were found in TMR. Among them, several molecules already known could be responsible for the antiplasmodial activity of the roots extract of T. macroptera. CONCLUSIONS: This study confirms both safety and anti-malarial activity of T. macroptera, thus validating its traditional use.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180214
[Lr] Last revision date:180214
[St] Status:In-Data-Review
[do] DOI:10.1186/s12936-018-2223-7

  6 / 1232 MEDLINE  
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[PMID]: 29431718
[Au] Autor:Swain KK; Mishra PM; Devi AP
[Ad] Address:Environment & Sustainability Department, CSIR-Institute of Minerals and Materials Technology, Bhubaneswar, Odisha 751013, India E-mail: pravatmanjari@yahoo.co.in; pravatmanjari@immt.res.in.
[Ti] Title:Biosorption of praseodymium (III) using Terminalia arjuna bark powder in batch systems: isotherm and kinetic studies.
[So] Source:Water Sci Technol;77(3):727-738, 2018 Feb.
[Is] ISSN:0273-1223
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The high demand for rare earth elements (REEs) used in various advanced materials implies demand for increased production of REEs or the recycling of solutions to recover the REEs they contain. In this study, the biosorption of Pr(III) from aqueous solution by bark powder of Terminalia arjuna was examined in a batch system as a function of metal concentration, biosorbent dosage, pH and contact time. Results showed that T. arjuna bark powder has a high affinity for adsorbing Pr(III): more than 90% at pH 6.63. The adsorption of Pr(III) by T. arjuna bark powder was investigated by the Langmuir, Freundlich, Temkin and Dubinin-Radushkevich isotherm models. The kinetics of the biosorption process was tested with pseudo-first-order and pseudo-second-order models, and the results showed that the biosorption process was better fitted to the pseudo-second-order model. From Fourier transform infrared spectroscopy (FT-IR) analysis, it is confirmed that the biomolecules of T. arjuna bark powder are involved in the biosorption process of Pr(III) metal ions.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180212
[Lr] Last revision date:180212
[St] Status:In-Data-Review
[do] DOI:10.2166/wst.2017.589

  7 / 1232 MEDLINE  
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[PMID]: 29422336
[Au] Autor:Behera DR; Bhatnagar S
[Ad] Address:Medicinal and Aromatic Plants, Regional Plant Resource Centre, Bhubaneswar, Odisha, India.
[Ti] Title:Assessment of macrofilaricidal activity of leaf extracts of Terminalia sp. against bovine filarial parasite Setaria cervi.
[So] Source:J Infect Public Health;, 2018 Feb 05.
[Is] ISSN:1876-035X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Antifilarial potential of three medicinal plants namely, Terminalia bellerica, Terminalia chebula and Terminalia catappa was explored using Setaria cervi, a bovine filarial parasite at concentrations of 2.5, 5 and 10mg/ml. Amongst all the extracts, methanol extract of T. bellerica showed highest macrofilaricidal activity i.e. 84.63±1.11 at 10mg/ml in MTT reduction assay with IC value of 2.7mg/ml. which was better than the standard DEC i.e. 79.22±3.1% at 10mg/ml with IC value 2.84mg/ml. Other plant extracts showed mild in vitro macrofilaricidal activity. T. bellerica methanol extract exhibited significant GST activity of 18.86±0.21 and 12.83±0.03µM/ml/min at 5 and 10mg/ml with percentage inhibition value of 73.96% and 82.29% respectively. DEC showed GST activity value of 40.03±4.14 and 21.48±6.44µM/ml/min with percentage inhibition value of 21.76% and 58.01% at 5 and 10mg/ml respectively. Thus, methanol extract of leaves of T. bellerica exhibited highly significant antifilarial potential and needs detailed analysis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180209
[Lr] Last revision date:180209
[St] Status:Publisher

  8 / 1232 MEDLINE  
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[PMID]: 29327455
[Au] Autor:Varghese A; Saboo P; Wairkar S
[Ad] Address:Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, Vile Parle (W), Mumbai, -400056, India.
[Ti] Title:Bioactivity guided fractionation of methanolic extract of Terminalia arjuna for its CYP3A and CYP2D inhibition in rat liver microsomes.
[So] Source:Biopharm Drug Dispos;, 2018 Jan 12.
[Is] ISSN:1099-081X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Terminalia arjuna (T. arjuna) is an Indian medicinal plant belonging to the family Combretaceae and possesses numerous therapeutic activities including its immense cardioprotective activity. In the present work, a methanolic bark extract of T. arjuna was evaluated for CYP3A and CYP2D inhibition potential in rat liver microsomes (RLM). Further, the methanolic bark extract was fractionated successively using increasing polarity solvents starting with petroleum ether, chloroform, ethyl acetate and n-butanol. The fractions so obtained were also evaluated for their CYP3A and CYP2D inhibition potential. Probe substrates testosterone and dextromethorphan were used for CYP3A and CYP2D respectively. The IC values for the methanolic extract and the fractions were found to be less than 50 µg/ml in RLM for both CYP3A and CYP2D isoenzymes. The most potent n-butanol fraction was further fractionated with column chromatography to isolate the highest active constituent responsible for the activity. Fraction 4 of the n-butanol extract was the most potent fraction with IC values of 5.64 ± 0.735 µg/ml and 16.63 ± 0.879 µg/ml for CYP3A and CYP2D in RLM, respectively. Therefore, in vitro data indicated that the Terminalia arjuna extract contains constituents that can potentially inhibit the CYP3A and CYP2D isoenzymes which may in turn lead to pharmacokinetic drug-herb interaction.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180208
[Lr] Last revision date:180208
[St] Status:Publisher
[do] DOI:10.1002/bdd.2121

  9 / 1232 MEDLINE  
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[PMID]: 29288719
[Au] Autor:Suganthy N; Muniasamy S; Archunan G
[Ad] Address:Department of Nanoscience and Technology, Alagappa University, Karaikudi, Tamil Nadu, India; Centre for Phermone Technology, Department of Animal Science, Bharadhidasan University, Triuchirappalli, Tamil Nadu, India. Electronic address: suganthyn@alagappauniversity.ac.in.
[Ti] Title:Safety assessment of methanolic extract of Terminalia chebula fruit, Terminalia arjuna bark and its bioactive constituent 7-methyl gallic acid: In vitro and in vivo studies.
[So] Source:Regul Toxicol Pharmacol;92:347-357, 2018 Feb.
[Is] ISSN:1096-0295
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Terminalia chebula and Terminalia arjuna were widely used in traditional medicine for the treatment of memory impairment, inflammatory disorders and as an anti-aging agent. However, reports regarding their safety aspects are lacking. Hence, the present study was carried out to investigate the toxicity of methanolic extracts of Terminalia chebula fruit (TCF), Terminalia arjuna bark (TAB) and its bioactive constituent 7- Methyl gallic acid (7MG) under in vitro and in vivo conditions. In vitro toxicity profile of TCF, TAB and 7MG (250-2000 µg/ml) were assessed through cytotoxicity, hemolytic activity, mutagenicity and genotoxicity assays. Results of Ames test, comet assay, MTT and hemolytic assays illustrated that TCF, TAB and 7MG exhibited neither cytotoxic and genotoxic effect in PBMC nor hemolytic activity in RBC and no mutagenic effect in TA 98 and TA 100 up to a limited dose of 2000 µg/ml. Acute and subacute toxicity studies showed no significant change in body weight, behavior, hematology, biochemical parameters, organ weight and histopathology. Over all the results of acute and subacute toxicity studies conclude that oral administration of TCF, TAB and 7MG were observed to be relatively non-toxic and affords practical guidance for selecting safe dose for further clinical trials.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180206
[Lr] Last revision date:180206
[St] Status:In-Process

  10 / 1232 MEDLINE  
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[PMID]: 29233773
[Au] Autor:Ekambaram SP; Babu KB; Perumal SS; Rajendran D
[Ad] Address:Department of Pharmaceutical Technology, University College of Engineering, Bharathidasan Institute of Technology Campus, Anna University, Tiruchirappalli 620 024, Tamilnadu, India. Electronic address: sanmug77@gmail.com.
[Ti] Title:Repeated oral dose toxicity study on hydrolysable tannin rich fraction isolated from fruit pericarps of Terminalia chebula Retz in Wistar albino rats.
[So] Source:Regul Toxicol Pharmacol;92:182-188, 2018 Feb.
[Is] ISSN:1096-0295
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Terminalia chebula fruits are one of the richest sources of hydrolysable tannins and it is well known medicinal agent in traditional systems of medicine for treatment of various chronic ailments. In the present study, hydrolysable tannin rich fraction (HTF) was isolated from 80% hydroalcoholic extract of Terminalia chebula fruit pericarps and it was studied for acute and repeated dose oral toxicity in Wistar albino rats. HTF did not show any toxic symptoms or mortality at single dose administration of 5000 mg/kg/p.o followed by observation for 14 days. On repeated dose 28 days oral toxicity study, administration of HTF at 1000 mg/kg showed marked reduction in body weight, food intake and water intake when compared with vehicle control. It was also observed that HTF could increase serum urea, glucose and AST level significantly when compared with vehicle control indicating mild disturbances in liver and kidney functions. On histopathological screening, HTF treatment showed a mild granulomatous inflammation in the liver and all other organs remained normal. It was concluded that following 28 days repeated dose oral administration, HTF caused mild disturbances in liver and kidney function which was indicated by reduced body weight, food and water intake, serum parameters and histological observations.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180206
[Lr] Last revision date:180206
[St] Status:In-Process


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