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[PMID]: 28956681
[Au] Autor:González-Stuart A; Rivera JO
[Ad] Address:a School of Pharmacy , University of Texas at El Paso , El Paso , TX , USA.
[Ti] Title:Yellow Oleander Seed, or "Codo de Fraile" (Thevetia spp.): A Review of Its Potential Toxicity as a Purported Weight-Loss Supplement.
[So] Source:J Diet Suppl;:1-13, 2017 Sep 28.
[Is] ISSN:1939-022X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The Dietary Supplements and Health Education Act (DSHEA), passed by the United States Congress in October of 1994, defines herbal products as nutritional supplements, not medications. This opened the market for diverse products made from plants, including teas, extracts, essential oils, and syrups. Mexico and the United States share an extensive border, where diverse herbal products are available to the public without a medical prescription. Research undertaken in the neighboring cities of Ciudad Juarez, Mexico, and El Paso, Texas, USA, shows the use of herbs is higher in this border area compared to the rest of the United States. A portion of the population is still under the erroneous impression that "natural" products are completely safe to use and therefore lack side effects. We review the dangers of ingesting the toxic seed of Thevetia spp. (family Apocynaceae), commonly known as "yellow oleander" or "codo de fraile," misleadingly advertised on the Internet as an effective and safe dietary supplement for weight loss. Lack of proper quality control regarding herbs generates a great variability in the quantity and quality of the products' content. Herb-drug interactions occur between some herbal products and certain prescription pharmaceuticals. Certain herbs recently introduced into the U.S. market may not have been previously tested adequately for purity, safety, and efficacy. Due to the lack of reliable clinical data regarding the safe use of various herbal products currently available, the public should be made aware regarding the possible health hazards of using certain herbs for therapeutic purposes. The potentially fatal toxicity of yellow oleander seed is confirmed by cases reported from various countries, while the purported benefits of using it for weight loss have not been evaluated by any known clinical trials. For this reason, the use of yellow oleander seed as a dietary supplement should be avoided.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170928
[Lr] Last revision date:170928
[St] Status:Publisher
[do] DOI:10.1080/19390211.2017.1353565

  2 / 123 MEDLINE  
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[PMID]: 28653199
[Au] Autor:Kaur M; Nagpal AK
[Ad] Address:Department of Botanical and Environmental Sciences, Guru Nanak Dev University Amritsar, Amritsar, Punjab, 143005, India.
[Ti] Title:Evaluation of air pollution tolerance index and anticipated performance index of plants and their application in development of green space along the urban areas.
[So] Source:Environ Sci Pollut Res Int;, 2017 Jun 26.
[Is] ISSN:1614-7499
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Air pollution due to vehicular emissions has become one of the most serious problems in the whole world and has resulted in huge threat to both the environment and the health of living organisms (plants, humans, animals, microorganisms). Plants growing along the roadsides get affected at the maximum as they are the primary recipients to different air pollutants and show varied levels of tolerance and sensitivity. Taking this into account, the present work was based on assessment of seasonal variation in air pollution tolerance index (APTI) and anticipated performance index (API) of four roadside plants, namely, Alstonia scholaris, Nerium oleander, Tabernaemontana coronaria, and Thevetia peruviana belonging to family Apocynaceae. APTI was calculated by the determination of four important biochemical parameters, viz., pH, relative water content (RWC), total chlorophyll (TChl), and ascorbic acid (AsA) content of leaves. The leaf samples were collected from plants growing at seven different sites of Amritsar (Punjab), India, for pre-monsoon and post-monsoon seasons. Highest APTI (82.14) was reported in N. oleander during the pre-monsoon season while the lowest was recorded in T. coronaria (18.59) in the post-monsoon season. On the basis of API score, A. scholaris was anticipated to be an excellent performer during the pre-monsoon and post-monsoon seasons followed by N. oleander, T. coronaria, and T. peruviana. Linear regression analysis and Pearson's correlation coefficient depicted significant positive correlation between APTI and ascorbic acid content during the pre-monsoon and post-monsoon seasons.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1706
[Cu] Class update date: 170816
[Lr] Last revision date:170816
[St] Status:Publisher
[do] DOI:10.1007/s11356-017-9500-9

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[PMID]: 27987091
[Au] Autor:Villegas A; Arias JP; Aragón D; Ochoa S; Arias M
[Ad] Address:Research Group on Simulation, Design, Control and Optimization of Chemical Processes (SIDCOP), Faculty of Engineering, Universidad de Antioquia, Calle 67 No 53, 108, Medellín, Colombia. adriana.villegas@ucc.edu.co.
[Ti] Title:Structured model and parameter estimation in plant cell cultures of Thevetia peruviana.
[So] Source:Bioprocess Biosyst Eng;40(4):573-587, 2017 Apr.
[Is] ISSN:1615-7605
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:In this work, a mechanistic model for predicting the dynamic behavior of extracellular and intracellular nutrients, biomass production, and the main metabolites involved in the central carbon metabolism in plant cell cultures of Thevetia peruviana is presented. The proposed model is the first mechanistic model implemented for plant cell cultures of this species, and includes 28 metabolites, 33 metabolic reactions, and 61 parameters. Given the over-parametrization of the model, its nonlinear nature and the strong correlation among the effects of the parameters, a parameter estimation routine based on identifiability analysis was implemented. This routine reduces the parameter's search space by selecting the most sensitive and linearly independent parameters. Results have shown that only 19 parameters are identifiable. Finally, the model was used for analyzing the fluxes distribution in plant cell cultures of T. peruviana. This analysis shows high uptake of phosphates and parallel uptake of glucose and fructose. Furthermore, it has pointed out the main central carbon metabolism routes for promoting biomass production in this cell culture.
[Mh] MeSH terms primary: Cell Culture Techniques/methods
Models, Biological
Plant Cells/metabolism
Thevetia/cytology
Thevetia/metabolism
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1704
[Cu] Class update date: 170428
[Lr] Last revision date:170428
[Js] Journal subset:IM
[Da] Date of entry for processing:161218
[St] Status:MEDLINE
[do] DOI:10.1007/s00449-016-1722-6

  4 / 123 MEDLINE  
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[PMID]: 27917871
[Au] Autor:Zhu JJ; Zhang XX; Miao YQ; He SF; Tian DM; Yao XS; Tang JS; Gan Y
[Ad] Address:Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Ji-nan University, Guangzhou 510632, China.
[Ti] Title:Delivery of acetylthevetin B, an antitumor cardiac glycoside, using polymeric micelles for enhanced therapeutic efficacy against lung cancer cells.
[So] Source:Acta Pharmacol Sin;38(2):290-300, 2017 Feb.
[Is] ISSN:1745-7254
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Acetylthevetin B (ATB), a cardiac glycoside from the seed of Thevetia peruviana (Pers) K Schum (yellow oleander), exhibits not only antitumor activity but also potential cardiac toxicity. In the present study, we attempted to enhance its antitumor action and decrease its adverse effects via chitosan-Pluronic P123 (CP) micelle encapsulation. Two ATB-loaded CP micelles (ATB-CP1, ATB-CP2) were prepared using an emulsion/solvent evaporation technique. They were spherical in shape with a particle size of 40-50 nm, showed a neutral zeta potential, and had acceptable encapsulation efficiency (>90%). Compared to the free ATB (IC =2.94 µmol/L), ATB-loaded CP micelles exerted much stronger cytotoxicity against human lung cancer A549 cells with lower IC values (0.76 and 1.44 µmol/L for ATB-CP1 and ATB-CP2, respectively). After administration of a single dose in mice, the accumulation of ATB-loaded CP1 micelles in the tumor and lungs, respectively, was 15.31-fold and 9.49-fold as high as that of free ATB. A549 xenograft tumor mice treated with ATB-loaded CP1 micelles for 21 d showed the smallest tumor volume (one-fourth of that in the control group) and the highest inhibition rate (85.6%) among all the treatment groups. After 21-d treatment, no significant pathological changes were observed in hearts and other main tissues. In summary, ATB may serve as a promising antitumor chemotherapeutic agent for lung cancer, and its antitumor efficacy was significantly improved by CP micelles, with lower adverse effects.
[Mh] MeSH terms primary: Cardiac Glycosides/administration & dosage
Cardiac Glycosides/pharmacology
Drug Carriers/chemistry
Micelles
Poloxalene/chemistry
[Mh] MeSH terms secundary: Animals
Cardiac Glycosides/therapeutic use
Cell Line, Tumor
Chitosan/chemistry
Humans
Mice
Particle Size
Xenograft Model Antitumor Assays
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Cardiac Glycosides); 0 (Drug Carriers); 0 (Micelles); 0 (acetylthevetin B); 0 (pluronic block copolymer P123); 9003-11-6 (Poloxalene); 9012-76-4 (Chitosan)
[Em] Entry month:1706
[Cu] Class update date: 170912
[Lr] Last revision date:170912
[Js] Journal subset:IM
[Da] Date of entry for processing:161206
[St] Status:MEDLINE
[do] DOI:10.1038/aps.2016.113

  5 / 123 MEDLINE  
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[PMID]: 27748195
[Au] Autor:Orhan IE; Gokbulut A; Senol FS
[Ad] Address:Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara, Turkey.
[Ti] Title:Adonis sp., Convallaria sp., Strophanthus sp., Thevetia sp., and Leonurus sp. - Cardiotonic Plants with Known Traditional Use and a Few Preclinical and Clinical Studies.
[So] Source:Curr Pharm Des;23(7):1051-1059, 2017.
[Is] ISSN:1873-4286
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Plants have been always a fruitful source of active metabolites against many human disorders, where cardiovascular (CV) diseases have been one of the major health problems all over the world. There are some clinically proved medicinal plants with cardioprotective effects such as Crataegus monogyna and C. oxyacantha (hawthorn) from Rosaceae. On the other hand, cardiac glycosides, present in a number of plant species, are wellknown for their cardiotonic activity. However, we encountered such a fact that very less number of studies are available on the source plants; e.g. Adonis vernalis, Convallaria majalis, Strophanthus kombe, Thevetia peruviana, Leonurus cardiaca, etc. Consequently, we herein aimed to cover all available data consisting of in vitro, in vivo, and human studies (if any) on cardiotonic effects of the aforementioned species through a wide literature search using Scopus, Web of Science as well as Pubmed.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 170620
[Lr] Last revision date:170620
[St] Status:In-Process
[do] DOI:10.2174/1381612822666161010104548

  6 / 123 MEDLINE  
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[PMID]: 28066105
[Au] Autor:Samanta J; Bhattacharya S; Rana AC
[Ad] Address:Rayat and Bahra Institute of Pharmacy, Mohali, Punjab, India.
[Ti] Title:Antifertility activity of (Pers.) K. Schum leaf in female Sprague-Dawley rat.
[So] Source:Indian J Pharmacol;48(6):669-674, 2016 Nov-Dec.
[Is] ISSN:1998-3751
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:OBJECTIVES: (Pers.) K. Schum. ( ) is known to possess cardioactive glycoside such as thevetin A, thevetin B, neriifolin, peruvoside, thevetoxin, and ruvoside. Traditionally, leaves are used as abortifacient. The aim of the present study is to evaluate antifertility potential of leaves. SUBJECTS AND METHODS: Cardiac glycoside freed leaves of were extracted with methanol using maceration method. The dried cardiac glycoside-free methanolic extract of leaves (TPL-Me-G) was screened for phytoconstituents and evaluated for its effect on estrogen-primed female Sprague-Dawley rat uterus model. It was further studied for effects on the estrous cycle, implantation, and effect on estrogen and progesterone. STATISTICAL ANALYSIS USED: Statistical analysis was done by ANOVA followed by Dunnett's -test. RESULTS: Alkaloids, flavonoids, essential oils, carbohydrates, and amino acids were found to be present in the glycoside-free extract. Thin-layer chromatography (TLC) in n-butanol: acetone: water (4:1:5) revealed the presence of quercetin and kaempferol. The presence of flavonoids (quercetin 0.0326% and kaempferol 0.138% on dry weight basis) was reconfirmed by high-performance TLC analysis. The extract was able to induce uterine contractions (EC , 0.170 mg/ml) in a dose-dependent manner. Further investigation showed significant ( < 0.001) extension of estrous cycle and anti-implantation activity of the extract by reduction of the progesterone level. CONCLUSIONS: Methanolic extract of leaves (TPL-Me-G) containing quercetin 0.0326% and kaempferol 0.138% possesses a significant ( < 0.001) antifertility potential by virtue of decreasing the progesterone level.
[Mh] MeSH terms primary: Contraceptive Agents, Female/pharmacology
Fertility/drug effects
Plant Extracts/pharmacology
Plant Leaves
Thevetia
Uterus/drug effects
[Mh] MeSH terms secundary: Animals
Contraceptive Agents, Female/isolation & purification
Estrogens/blood
Estrous Cycle/drug effects
Estrous Cycle/physiology
Female
Fertility/physiology
Organ Culture Techniques
Plant Extracts/isolation & purification
Pregnancy
Progesterone/antagonists & inhibitors
Progesterone/blood
Rats
Rats, Sprague-Dawley
Toxicity Tests, Acute/methods
Uterus/physiology
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Contraceptive Agents, Female); 0 (Estrogens); 0 (Plant Extracts); 4G7DS2Q64Y (Progesterone)
[Em] Entry month:1706
[Cu] Class update date: 170817
[Lr] Last revision date:170817
[Js] Journal subset:IM
[Da] Date of entry for processing:170110
[St] Status:MEDLINE
[do] DOI:10.4103/0253-7613.194861

  7 / 123 MEDLINE  
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[PMID]: 27541569
[Au] Autor:Arias JP; Zapata K; Rojano B; Arias M
[Ad] Address:Escuela de Biociencias, Facultad de Ciencias, Universidad Nacional de Colombia, sede Medellín, Medellín, Antioquia, Colombia. Electronic address: jpariase@unal.edu.co.
[Ti] Title:Effect of light wavelength on cell growth, content of phenolic compounds and antioxidant activity in cell suspension cultures of Thevetia peruviana.
[So] Source:J Photochem Photobiol B;163:87-91, 2016 Oct.
[Is] ISSN:1873-2682
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Thevetia peruviana (T. peruviana) has been considered as a potentially important plant for industrial and pharmacological application. Among the number of compounds which are produced by T. peruviana, antioxidants and polyphenols are of particular interest due to their benefits on human health. Cell suspension cultures of T. peruviana were established under different conditions: 1) constant illumination (24h/day) at different light wavelengths (red, green, blue, yellow and white), 2) darkness and 3) control (12h/12h: day light/dark) to investigate their biomass, substrate uptake, polyphenols production and oxidizing activity. The results showed biomass concentrations between 17.1g dry weight (DW)/l (green light) and 18.2g DW/l (control) after 13days. The cultures that grew under green light conditions consumed completely all substrates after 10days, while other cultures required at least 13days or more. The total phenolic content was between 7.21 and 9.46mg gallic acid (GA)/g DW for all light conditions. In addition the ferric reducing antioxidant power and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid antioxidant activity ranged from 5.41-6.58mg ascorbic acid (AA)/g DW and 82.93-110.39µmol Trolox/g DW, respectively. Interestingly, the samples which grew under the darkness presented a higher phenolic content and antioxidant capacity when compared to the light conditions. All together, these results demonstrate the extraordinary effect of different lighting conditions on polyphenols production and antioxidant compounds by T. peruviana.
[Mh] MeSH terms primary: Antioxidants/metabolism
Antioxidants/pharmacology
Light
Polyphenols/metabolism
Polyphenols/pharmacology
Thevetia/cytology
Thevetia/metabolism
[Mh] MeSH terms secundary: Biological Transport/radiation effects
Cell Proliferation/radiation effects
Cells, Cultured
Suspensions
Thevetia/radiation effects
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antioxidants); 0 (Polyphenols); 0 (Suspensions)
[Em] Entry month:1703
[Cu] Class update date: 170309
[Lr] Last revision date:170309
[Js] Journal subset:IM
[Da] Date of entry for processing:160820
[St] Status:MEDLINE

  8 / 123 MEDLINE  
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[PMID]: 27490374
[Au] Autor:Hien DF; Dabiré KR; Roche B; Diabaté A; Yerbanga RS; Cohuet A; Yameogo BK; Gouagna LC; Hopkins RJ; Ouedraogo GA; Simard F; Ouedraogo JB; Ignell R; Lefevre T
[Ad] Address:Institut de Recherche en Sciences de la Santé (IRSS), Bobo Dioulasso, Burkina Faso.
[Ti] Title:Plant-Mediated Effects on Mosquito Capacity to Transmit Human Malaria.
[So] Source:PLoS Pathog;12(8):e1005773, 2016 Aug.
[Is] ISSN:1553-7374
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The ecological context in which mosquitoes and malaria parasites interact has received little attention, compared to the genetic and molecular aspects of malaria transmission. Plant nectar and fruits are important for the nutritional ecology of malaria vectors, but how the natural diversity of plant-derived sugar sources affects mosquito competence for malaria parasites is unclear. To test this, we infected Anopheles coluzzi, an important African malaria vector, with sympatric field isolates of Plasmodium falciparum, using direct membrane feeding assays. Through a series of experiments, we then examined the effects of sugar meals from Thevetia neriifolia and Barleria lupilina cuttings that included flowers, and fruit from Lannea microcarpa and Mangifera indica on parasite and mosquito traits that are key for determining the intensity of malaria transmission. We found that the source of plant sugar meal differentially affected infection prevalence and intensity, the development duration of the parasites, as well as the survival and fecundity of the vector. These effects are likely the result of complex interactions between toxic secondary metabolites and the nutritional quality of the plant sugar source, as well as of host resource availability and parasite growth. Using an epidemiological model, we show that plant sugar source can be a significant driver of malaria transmission dynamics, with some plant species exhibiting either transmission-reducing or -enhancing activities.
[Mh] MeSH terms primary: Culicidae
Feeding Behavior
Insect Vectors
Malaria, Falciparum/transmission
Plants
[Mh] MeSH terms secundary: Animals
Humans
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1706
[Cu] Class update date: 170910
[Lr] Last revision date:170910
[Js] Journal subset:IM
[Da] Date of entry for processing:160805
[St] Status:MEDLINE
[do] DOI:10.1371/journal.ppat.1005773

  9 / 123 MEDLINE  
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[PMID]: 27167183
[Au] Autor:Wen S; Chen Y; Lu Y; Wang Y; Ding L; Jiang M
[Ad] Address:Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; Research and Development Center of TCM, Tianjin, International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China.
[Ti] Title:Cardenolides from the Apocynaceae family and their anticancer activity.
[So] Source:Fitoterapia;112:74-84, 2016 Jul.
[Is] ISSN:1873-6971
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Cardenolides, as a group of natural products that can bind to Na(+)/K(+)-ATPase with an inhibiting activity, are traditionally used to treat congestive heart failure. Recent studies have demonstrated that the strong tumor cytotoxicities of cardenolides are mainly due to inducing the tumor cells apoptosis through different expression and cellular location of Na(+)/K(+)-ATPase α-subunits. The leaves, flesh, seeds and juices of numerous plants from the genera of Nerium, Thevetia, Cerbera, Apocynum and Strophanthus in Apocynaceae family, are the major sources of natural cardenolides. So far, 109 cardenolides have been isolated and identified from this family, and about a quarter of them are reported to exhibit the capability to regulate cancer cell survival and death through multiple signaling pathways. In this review, we compile the phytochemical characteristics and anticancer activity of the cardenolides from this family.
[Mh] MeSH terms primary: Antineoplastic Agents, Phytogenic/pharmacology
Apocynaceae/chemistry
Cardenolides/pharmacology
[Mh] MeSH terms secundary: Cell Line, Tumor
Humans
Molecular Structure
Phytochemicals/pharmacology
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Antineoplastic Agents, Phytogenic); 0 (Cardenolides); 0 (Phytochemicals)
[Em] Entry month:1702
[Cu] Class update date: 170213
[Lr] Last revision date:170213
[Js] Journal subset:IM
[Da] Date of entry for processing:160512
[St] Status:MEDLINE

  10 / 123 MEDLINE  
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[PMID]: 27086856
[Au] Autor:Cheng HY; Tian DM; Tang JS; Shen WZ; Yao XS
[Ad] Address:a Department of Anatomy , Medical College, Jinan University , Guangzhou 510632 , China.
[Ti] Title:Cardiac glycosides from the seeds of Thevetia peruviana and their pro-apoptotic activity toward cancer cells.
[So] Source:J Asian Nat Prod Res;18(9):837-47, 2016 Sep.
[Is] ISSN:1477-2213
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Phytochemical investigation of the seeds of Thevetia peruviana resulted in the isolation of seven cardiac glycosides (1-7), including two new compounds (1 and 2). Cytotoxicity of them toward cancer cell lines P15 (human lung cancer cell), MGC-803 (human gastric cancer cells), SW1990 (human pancreatic cancer cells), and normal hepatocyte cell LO2 suggested that compound 1 could selectively inhibit the proliferation of cancer cell lines with IC50 from 0.05 to 0.15 µM. Pro-apoptotic activity revealed that it induced the apoptosis of MGC-803 cancer cells in a dose-dependent manner. Meanwhile, treatment of MGC-803 cancer cells with 1 resulted in diminution of pro-caspases 3 and 9 and activation of caspases 3 and 9, while it increased the Bax/Bcl-2 ratio in a dose-dependent manner. These meant that 1 induced the apoptosis of cancer cells by involving the intrinsic apoptotic pathway. In addition, the cell cycle distribution of MGC-803 cancer cells treated by 1 revealed that it could lead to cell cycle arrest at the G2/M phase. Altogether, this study suggested that compound 1 may exhibit anticancer activity by its capability of induction of intrinsic apoptosis and cell cycle arrest at G2/M phase.
[Mh] MeSH terms primary: Cardiac Glycosides/isolation & purification
Cardiac Glycosides/pharmacology
Drugs, Chinese Herbal/isolation & purification
Drugs, Chinese Herbal/pharmacology
Seeds/chemistry
Thevetia/chemistry
[Mh] MeSH terms secundary: Cardiac Glycosides/chemistry
Caspase 3/metabolism
Caspases/metabolism
Cell Cycle/drug effects
Drug Screening Assays, Antitumor
Drugs, Chinese Herbal/chemistry
Humans
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Cardiac Glycosides); 0 (Drugs, Chinese Herbal); EC 3.4.22.- (Caspase 3); EC 3.4.22.- (Caspases)
[Em] Entry month:1702
[Cu] Class update date: 170203
[Lr] Last revision date:170203
[Js] Journal subset:IM
[Da] Date of entry for processing:160419
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2016.1170814


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