Database : MEDLINE
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[PMID]: 29368126
[Au] Autor:Holtkamp M
[Ad] Address:Epilepsy-Center Berlin-Brandenburg, Department of Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany. martin.holtkamp@charite.de.
[Ti] Title:Pharmacotherapy for Refractory and Super-Refractory Status Epilepticus in Adults.
[So] Source:Drugs;78(3):307-326, 2018 Mar.
[Is] ISSN:1179-1950
[Cp] Country of publication:New Zealand
[La] Language:eng
[Ab] Abstract:Patients with prolonged seizures that do not respond to intravenous benzodiazepines and a second-line anticonvulsant suffer from refractory status epilepticus and those with seizures that do not respond to continuous intravenous anesthetic anticonvulsants suffer from super-refractory status epilepticus. Both conditions are associated with significant morbidity and mortality. A strict pharmacological treatment regimen is urgently required, but the level of evidence for the available drugs is very low. Refractory complex focal status epilepticus generally does not require anesthetics, but all intravenous non-anesthetizing anticonvulsants may be used. Most descriptive data are available for levetiracetam, phenytoin and valproate. Refractory generalized convulsive status epilepticus is a life-threatening emergency, and long-term clinical consequences are eminent. Administration of intravenous anesthetics is mandatory, and drugs acting at the inhibitory gamma-aminobutyric acid (GABA) receptor such as midazolam, propofol and thiopental/pentobarbital are recommended without preference for one of those. One in five patients with anesthetic treatment does not respond and has super-refractory status epilepticus. With sustained seizure activity, excitatory N-methyl-d-aspartate (NMDA) receptors are increasingly expressed post-synaptically. Ketamine is an antagonist at this receptor and may prove efficient in some patients at later stages. Neurosteroids such as allopregnanolone increase sensitivity at GABA receptors; a Phase 1/2 trial demonstrated safety and tolerability, but randomized controlled data failed to demonstrate efficacy. Adjunct ketogenic diet may contribute to termination of difficult-to-treat status epilepticus. Randomized controlled trials are needed to increase evidence for treatment of refractory and super-refractory status epilepticus, but there are multiple obstacles for realization. Hitherto, prospective multicenter registries for pharmacological treatment may help to improve our knowledge.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:In-Process
[do] DOI:10.1007/s40265-017-0859-1

  2 / 7459 MEDLINE  
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[PMID]: 29432502
[Au] Autor:Wojdacz R; Swiecicki L; Antosik-Wójcinska A
[Ad] Address:Instytut Psychiatrii i Neurologii w Warszawie.
[Ti] Title:Porównanie wplywu anestetyków dozylnych stosowanych do znieczulenia w trakcie leczenia elektrowstrzasowego na bezpieczenstwo hemodynamiczne i przebieg zabiegów elektrowstrzasowych. Comparison of the effect of intravenous anesthetics used for anesthesia during electroconvulsive therapy on the hemodynamic safety and the course of ECT.
[So] Source:Psychiatr Pol;51(6):1039-1058, 2017 Dec 30.
[Is] ISSN:2391-5854
[Cp] Country of publication:Poland
[La] Language:eng; pol
[Ab] Abstract:Electroconvulsive therapy (ECT) is the treatment method widely used in psychiatric disorders such as depression, bipolar disorder, schizophrenia and schizoaffective disorder. The advantage of ECT is therapeutic response that occurs significantly earlier than during pharmacotherapy. Initially ECTwas used without anesthesia. Then, in the 1950s procedures with general anesthesia were introduced to reduce the complications that may occur during a seizure caused by ECT, such as broken bones, teeth, tendon rupture, muscle damage. Currently, in general anesthesia for ECTseveral medications are used interchangeably: thiopental, propofol, etomidate and ketamine. In different resorts and different countries different anestethics are used, the choice is determined mainly by the experience of each resort and a kind of tradition. The authors provide an overview of objective data showing how various anesthetics affect the quality of ECT and the presence of any hemodynamic complications after ETC. Selection of articles included in this paper was made by searching Medline and PubMed databases using specific keywords: electroconvulsive therapy, general anesthesia, the risks and benefits of thiopental, ketamine, propofol and etomidate. The results of this review are inconclusive when it comes to the effect of intravenous anesthetics on the quality of the ECT treatment and side effects relating to respiratory and cardiovascular system. On this basis it is impossible to determine which of intravenous anesthetics is most advantageous from the point of view of the patient. To develop the optimum scheme of anesthesia for ECT, it is necessary to conduct further, methodologically correct studies.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1802
[Cu] Class update date: 180212
[Lr] Last revision date:180212
[St] Status:In-Process

  3 / 7459 MEDLINE  
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[PMID]: 29351759
[Au] Autor:Cabrini L; Landoni G; Baiardo Radaelli M; Saleh O; Votta CD; Fominskiy E; Putzu A; Snak de Souza CD; Antonelli M; Bellomo R; Pelosi P; Zangrillo A
[Ad] Address:Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.
[Ti] Title:Tracheal intubation in critically ill patients: a comprehensive systematic review of randomized trials.
[So] Source:Crit Care;22(1):6, 2018 Jan 20.
[Is] ISSN:1466-609X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: We performed a systematic review of randomized controlled studies evaluating any drug, technique or device aimed at improving the success rate or safety of tracheal intubation in the critically ill. METHODS: We searched PubMed, BioMed Central, Embase and the Cochrane Central Register of Clinical Trials and references of retrieved articles. Finally, pertinent reviews were also scanned to detect further studies until May 2017. The following inclusion criteria were considered: tracheal intubation in adult critically ill patients; randomized controlled trial; study performed in Intensive Care Unit, Emergency Department or ordinary ward; and work published in the last 20 years. Exclusion criteria were pre-hospital or operating theatre settings and simulation-based studies. Two investigators selected studies for the final analysis. Extracted data included first author, publication year, characteristics of patients and clinical settings, intervention details, comparators and relevant outcomes. The risk of bias was assessed with the Cochrane Collaboration's Risk of Bias tool. RESULTS: We identified 22 trials on use of a pre-procedure check-list (1 study), pre-oxygenation or apneic oxygenation (6 studies), sedatives (3 studies), neuromuscular blocking agents (1 study), patient positioning (1 study), video laryngoscopy (9 studies), and post-intubation lung recruitment (1 study). Pre-oxygenation with non-invasive ventilation (NIV) and/or high-flow nasal cannula (HFNC) showed a possible beneficial role. Post-intubation recruitment improved oxygenation while ramped position increased the number of intubation attempts and thiopental had negative hemodynamic effects. No effect was found for use of a checklist, apneic oxygenation (on oxygenation and hemodynamics), videolaryngoscopy (on number and length of intubation attempts), sedatives and neuromuscular blockers (on hemodynamics). Finally, videolaryngoscopy was associated with severe adverse effects in multiple trials. CONCLUSIONS: The limited available evidence supports a beneficial role of pre-oxygenation with NIV and HFNC before intubation of critically ill patients. Recruitment maneuvers may increase post-intubation oxygenation. Ramped position increased the number of intubation attempts; thiopental had negative hemodynamic effects and videolaryngoscopy might favor adverse events.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180201
[Lr] Last revision date:180201
[St] Status:In-Data-Review
[do] DOI:10.1186/s13054-017-1927-3

  4 / 7459 MEDLINE  
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[PMID]: 29209787
[Au] Autor:Luckscheiter A; Fischer M; Zink W
[Ad] Address:Klinik für Anästhesiologie und Operative Intensivmedizin, Klinikum Ludwigshafen, Bremserstr. 79, 67063, Ludwigshafen, Deutschland. luckscha@klilu.de.
[Ti] Title:Notärztliche Erfahrung im Umgang mit Narkosemedikamenten : Ergebnisse einer Umfrage. [Different levels of experience with anesthetic agents of German emergency physicians : Results of an online survey].
[So] Source:Anaesthesist;67(1):9-17, 2018 Jan.
[Is] ISSN:1432-055X
[Cp] Country of publication:Germany
[La] Language:ger
[Ab] Abstract:BACKGROUND AND OBJECTIVE: In 2015 practice management guidelines on prehospital emergency anesthesia in adults were published in Germany. The aim of the present study was to evaluate whether emergency physicians follow these guidelines in daily practice and to assess their level of experience with the use of anesthetic agents. MATERIAL AND METHODS: In an online survey the way of induction of preclinical anesthesia (including preoxygenation time and applied monitoring techniques) was assessed with the help of virtual scenarios based on the guidelines. Furthermore, the individual level of experience with specific anesthetic agents was estimated by the total number of anesthetic procedures performed with these drugs (0, 1-10, 11-25, 26-50, 51-100, and >100 procedures). RESULT: A total of 155 emergency physicians answered the online survey. Except for cardiac patients and for the preoxygenation time, we found a high accordance between specific algorithms proposed in the guidelines and emergency physicians' clinical practice. Furthermore, the median level of experience with rocuronium and succinylcholine was significantly higher compared to vecuronium. With respect to induction agents the highest level of experience was found for propofol and thiopental, the lowest for the combination of ketamine/propofol and midazolam. Generally, compared to non-anesthetists, emergency physicians had significantly higher levels of experience with the use of these anesthetic agents (except for etomidate and vecuronium). Over 94% used a 4-lead electrocardiogram (ECG), pulse oxymetry, non-invasive blood pressure and quantitative capnography for monitoring. The availability of succinylcholine was 91%, rocuronium 55%, vecuronium 29% and sugammadex 9%. CONCLUSION: The results of this survey demonstrate that clinical practice of emergency physicians is in high accordance with the recommendations named in the guidelines for prehospital emergency anesthesia in adults (except for cardiac patients and time of preoxygenation). With respect to the lower levels of experience of non-anesthetists in the use of anesthetic drugs, specific training concepts may help to further improve the quality of preclinical emergency care.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180129
[Lr] Last revision date:180129
[St] Status:In-Data-Review
[do] DOI:10.1007/s00101-017-0386-1

  5 / 7459 MEDLINE  
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[PMID]: 29347949
[Au] Autor:Kim R
[Ad] Address:Breast Surgery, Hiroshima Mark Clinic, 1-4-3F, 2-chome, Ohte-machi, Naka-ku, Hiroshima, Japan. ryu@hbc-center.com.
[Ti] Title:Effects of surgery and anesthetic choice on immunosuppression and cancer recurrence.
[So] Source:J Transl Med;16(1):8, 2018 Jan 18.
[Is] ISSN:1479-5876
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: The relationship between surgery and anesthetic-induced immunosuppression and cancer recurrence remains unresolved. Surgery and anesthesia stimulate the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) to cause immunosuppression through several tumor-derived soluble factors. The potential impact of surgery and anesthesia on cancer recurrence was reviewed to provide guidance for cancer surgical treatment. METHODS: PubMed was searched up to December 31, 2016 using search terms such as, "anesthetic technique and cancer recurrence," "regional anesthesia and cancer recurrence," "local anesthesia and cancer recurrence," "anesthetic technique and immunosuppression," and "anesthetic technique and oncologic surgery." RESULTS: Surgery-induced stress responses and surgical manipulation enhance tumor metastasis via release of angiogenic factors and suppression of natural killer (NK) cells and cell-mediated immunity. Intravenous agents such as ketamine and thiopental suppress NK cell activity, whereas propofol does not. Ketamine induces T-lymphocyte apoptosis but midazolam does not affect cytotoxic T-lymphocytes. Volatile anesthetics suppress NK cell activity, induce T-lymphocyte apoptosis, and enhance angiogenesis through hypoxia inducible factor-1α (HIF-1α) activity. Opioids suppress NK cell activity and increase regulatory T cells. CONCLUSION: Local anesthetics such as lidocaine increase NK cell activity. Anesthetics such as propofol and locoregional anesthesia, which decrease surgery-induced neuroendocrine responses through HPA-axis and SNS suppression, may cause less immunosuppression and recurrence of certain types of cancer compared to volatile anesthetics and opioids.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1801
[Cu] Class update date: 180128
[Lr] Last revision date:180128
[St] Status:In-Data-Review
[do] DOI:10.1186/s12967-018-1389-7

  6 / 7459 MEDLINE  
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[PMID]: 29359965
[Au] Autor:Nunes DV; Costa CA; De Bem GF; Cordeiro VS; Santos IB; Carvalho LC; Jordão AK; Cunha AC; Ferreira VF; Moura RS; Resende AC; Ognibene DT
[Ad] Address:a Department of Pharmacology , Institute of Biology, Rio de Janeiro State University , Rio de Janeiro , RJ , Brazil.
[Ti] Title:Tempol, a superoxide dismutase-mimetic drug, prevents chronic ischemic renal injury in two-kidney, one-clip hypertensive rats.
[So] Source:Clin Exp Hypertens;:1-9, 2018 Jan 23.
[Is] ISSN:1525-6006
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Tempol, a superoxide dismutase-mimetic drug, has been shown to attenuate radical-induced damage, exerting beneficial effects in the animal models of oxidative stress and hypertension. This study evaluated the effect of Tempol on renal structural and functional alterations in two-Kidney, one-Clip hypertensive rats. In this study, young male Wistar rats had the left kidney clipped (2K1C), and sham-operated animals (Sham) were used as controls. Animals received Tempol (1mmol/L in drinking water) or vehicle for 5 weeks. Systolic blood pressure was evaluated once a week. At the end of the experimental protocol, the animals were placed in metabolic cages to collect urine (24h) and then anesthetized with thiopental (70mg/kg i.p.) to collect blood by puncturing the descending aorta for biochemical analysis, and the clipped kidney for morphological and immunohistochemical analyses. The vasodilator effect of Tempol was evaluated in mesenteric arterial bed (MAB) isolated from adult Wistar rats. The chronic treatment with Tempol prevented the development of hypertension and the increased plasma levels of urea, creatinine, and 8-isoprostane in 2K1C animals. Tempol also improved both glomeruli number and kidney volume to normal levels in the 2K1C+Tempol group. In addition, the treatment prevented the increased collagen deposition and immunostaining for renin, caspase-3, and 8-isoprostane in the stenotic kidney of 2K1C animals. Moreover, Tempol induced a dose-dependent vasodilator response in MAB from Wistar rats. These results suggest that Tempol protects the stenotic kidney against chronic ischemic renal injury and prevents renal dysfunction in the 2K1C model, probably through its antioxidant, vasodilator and antihypertensive actions.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180123
[Lr] Last revision date:180123
[St] Status:Publisher
[do] DOI:10.1080/10641963.2018.1425423

  7 / 7459 MEDLINE  
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[PMID]: 29350659
[Au] Autor:Nuzzi M; Delmonte D; Barbini B; Pasin L; Sottocorna O; Casiraghi GM; Colombo C; Landoni G; Zangrillo A
[Ad] Address:San Raffaele Scientific Institute, Milan - Italy. nuzzi.massimiliano@hsr.it.
[Ti] Title:Thiopental is better than propofol for electroconvulsive therapy.
[So] Source:Acta Biomed;88(4):450-456, 2018 Jan 16.
[Is] ISSN:0392-4203
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:BACKGROUND AND AIM OF THE WORK: electroconvulsive therapy is a psychiatric procedure requiring general anesthesia. The choice of the hypnotic agent is important because the success of the intervention is associated to the occurrence and duration of motor convulsion. However, all available anesthetic agents have anti-convulsant activity. We compared the effect of thiopental and propofol on seizures. METHODS: We designed a retrospective study at Mood Disorders Unit of a teaching Hospital. Fifty-six consecutive patients undergoing electroconvulsive therapy were enrolled. Patients received fentanyl followed by either thiopental or propofol. We evaluated the incidence and the duration of seizure after electric stimulus at the first session of electroconvulsive therapy for each patient. Adverse perioperative effects were recorded. RESULTS: Patients were 60±12.1 years old and 64% was female. There was a statistically significant higher number of patients who had motor convulsion activity in the thiopental group when compared to the propofol group (25 vs 13, p=0.023). Seizure duration was statistically significant longer in the thiopental group than in the propofol group (35 sec vs 11 sec, p=0.046). No hemodynamic instability, oxygen desaturation episodes, prolonged recovery time from anesthesia and adverse effects related to anesthesia were recorded. CONCLUSIONS: Thiopental induction has a favourable effect on seizure when compared to propofol in patients undergoing electroconvulsive therapy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180119
[Lr] Last revision date:180119
[St] Status:In-Data-Review
[do] DOI:10.23750/abm.v88i4.6094

  8 / 7459 MEDLINE  
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[PMID]: 29348108
[Au] Autor:Anilanmert B; Narin I; Aydin I; Acikkol M
[Ad] Address:Istanbul University Institute of Forensic Sciences, Cerrahpasa, Istanbul, Turkey.
[Ti] Title:Report: Fast chromatographic screening method for 7 drugs of potential threat in drug facilitated crimes.
[So] Source:Pak J Pharm Sci;31(1):231-235, 2018 Jan.
[Is] ISSN:1011-601X
[Cp] Country of publication:Pakistan
[La] Language:eng
[Ab] Abstract:In cases where pharmaceuticals and pharmaceutical candidates are involved in drug facilitated crimes (DFC), like organ theft, robbery, rape and suicides, the analysis of drug powders or solution residues found in crime scenes may give idea on what the victims have ingested. An easy and fast simultaneous determination of 7 drugs; GHB (γ-hydroxybutyrate), GBL (γ-butyrolactone), norketamine, ketamine, fenobarbital, fenitoin and thiopental which have the potential to be used in DFC was performed. The method required no sample preparation and has 12 minutes elution time with a good chromatographic separation. The separation was carried out on a C monolithic column with UV detection at 215 and 237nm. All r2 values were ≥0.99 and the linear ranges were between 0.9956-1.0000. The LOD and LOQ values were between 0.56-5.55µgmL and 1.69-16.82µgmL respectively. The repeatability values were <7.35%. This is the first study in the simultaneous screening of the above mentioned drugs using HPLC.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180119
[Lr] Last revision date:180119
[St] Status:In-Data-Review

  9 / 7459 MEDLINE  
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[PMID]: 29244921
[Au] Autor:Trush VV; Sobolev VI
[Ti] Title:Influence of iatrogenic hypercorticoidism induced by long-term application of dexamethasone on power of muscular contraction of white rats.
[So] Source:Patol Fiziol Eksp Ter;60(4):39-46, 2016 Oct-Dec.
[Is] ISSN:0031-2991
[Cp] Country of publication:Russia (Federation)
[La] Language:eng
[Ab] Abstract:Research objective consisted in detection of nature of the changes of the myothermiс and the ergometric parameters of the contraction of the forward tibial muscle of rats in the course of performing of the tiring work at the saturation of an organism by therapeutic doses of dexamethasone. Method: The experiments were performed on sexually mature rats-females (200-220 g), divided into control (n = 10) and experimental (n = 60) groups. The animals of experimental group received dexamethasone (D, KRKA, Slovenia) in a dose of 0,25 mg/kg (intraperitoneal, 1 time in 2 days) during from 10 to 60 days. On anesthetized animals (sodium thiopental, 100 mg/kg) with the use of myothermia and ergographia the nature of change of power of the muscle's contraction in the course of the performance of the tiring work (3 six-second tetanus with external loading of 80 g) was studied. Restults: At the initial stage of the development of iatrogenic hypercorticoidism (after 5-20 injections of D) the initial value of the external work of the muscle in comparison with the control is significantly lower (for 30-52%) and the temperature cost of the unit of the work (TCMW), on the contrary, - is higher (for 26-82%). On the end of the 2-month period of application of D the initial values of the power parameters of the muscle came back to control level. During the performance of the tiring tetanus in animal experimental groups the decline of the external work of the muscle is greater (69-73%) compared with the control (55%). This effect does not depend of the number of injections of D, which indicates about a high pathophysiological activity of glucocorticoid concerning working capacity of the muscle. At expressed fatigue the TCMW always increases from 104% (5 injections of D) to 230% (20 injections); at control animals the effect of the tiring work on TCMW is significantly weaker (28%). At long-term application of D (2 months) the described effect of the preparation is weakened, though remains accurately expressed. Conclusion: The obtained data are considered from the point of view of formation at the hypercorticoidizm of the pathophysiological mechanism - the increase of power cost of muscular work. The revealed effect of D can be the cornerstone of the formation of the number of the pathophysiological mechanisms in neuromuscular system including causing the development of the myopathy at the hypercorticoidizm.
[Mh] MeSH terms primary: Adrenocortical Hyperfunction
Dexamethasone/adverse effects
Muscle Contraction
Muscle Strength
[Mh] MeSH terms secundary: Adrenocortical Hyperfunction/chemically induced
Adrenocortical Hyperfunction/physiopathology
Animals
Dexamethasone/pharmacology
Male
Rats
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:7S5I7G3JQL (Dexamethasone)
[Em] Entry month:1801
[Cu] Class update date: 180118
[Lr] Last revision date:180118
[Js] Journal subset:IM
[Da] Date of entry for processing:171216
[St] Status:MEDLINE

  10 / 7459 MEDLINE  
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[PMID]: 29315987
[Au] Autor:Heiderich S; Auf der Springe A; Jürgens J; Koppert W; Leffler A; Sümpelmann R; Dennhardt N
[Ad] Address:Clinic of Anesthesiology, Hanover Medical School, Hanover, Germany.
[Ti] Title:Compatibility of common IV drugs with 6% hydroxyethyl starch 130/0.42 and 4% gelatin.
[So] Source:Paediatr Anaesth;28(2):87-93, 2018 Feb.
[Is] ISSN:1460-9592
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:BACKGROUND: Acetate-containing colloid infusion solutions are recommended to recover normovolemia during pediatric anesthesia. Until now, no studies investigating the compatibility with common anesthetic drugs were available. AIMS: This in vitro study was conducted to reveal possible incompatibilities between common anesthetic drugs and the acetate-containing colloid infusion solutions 6% hydroxyethyl starch and 4% gelatin with normal saline as control. METHODS: The colloid infusion solutions were mixed 1:1 with 29 common intravenous drugs in concentrations used in daily clinical practice. Macroscopically visible changes as well as electrical conductivity, pH, and turbidimetric light diffusion at 405 nm were measured immediately after mixing and subsequently 30 and 60 minutes later. All experiments were conducted in triplicate. RESULTS: Fifty-nine of the 87 colloid infusion-drug mixtures showed no significant changes in pH, electrical conductivity, turbidimetrically detectable light diffusion, or macroscopic appearance after mixing with hydroxyethyl starch, gelatin, and NaCl 0.9%. Fifteen mixtures showed equivocal reactions, and 13 mixtures showed incompatibility reactions. CONCLUSION: Most of the tested drugs did not show observable incompatibility reactions. However, some common drugs are highly incompatible with colloid infusion solutions: gelatin (cefazolin, diazepam, midazolam, phenytoin, vancomycin), hydroxyethyl starch (diazepam, midazolam, phenytoin, thiopental), and NaCl 0.9% (diazepam, ketamine (S), phenytoin, thiopental). These combinations should be avoided in clinical practice in case there are fewer intravenous lines available than needed.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180118
[Lr] Last revision date:180118
[St] Status:In-Data-Review
[do] DOI:10.1111/pan.13309


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