Database : MEDLINE
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[PMID]: 29096966
[Au] Autor:Ríos A; Rodríguez JM; Torregrosa NM; Torregrosa B; Cepero A; Abellán MD; Hernández AM; Parrilla P
[Ad] Address:Departamento de Cirugía, Pediatría y Obstetricia y Ginecología, Universidad de Murcia, Murcia, España; Servicio de Cirugía General y de Aparato Digestivo, Hospital Clínico Universitario Virgen de la Arrixaca, Servicio Murciano de Salud, El Palmar, Murcia, España; Instituto Murciano de Investigación
[Ti] Title:Evaluación del nódulo tiroideo con la ecografía y elastografía de alta resolución sin la punción-aspiración con aguja fina. Evaluation of the thyroid nodule with high-resolution ultrasonography and elastography without fine needle aspiration biopsy.
[So] Source:Med Clin (Barc);, 2017 Oct 30.
[Is] ISSN:1578-8989
[Cp] Country of publication:Spain
[La] Language:eng; spa
[Ab] Abstract:INTRODUCTION: Fine needle aspiration biopsy (FNAB) is the gold standard screening technique used in the diagnostic protocol for thyroid nodules. However, it is not free of complications. OBJECTIVE: To identify thyroid nodules in which FNAB could be avoided during the diagnostic process by means of the use of a high-resolution ultrasonography or elastography. MATERIAL AND METHOD: A prospective, non-randomized study was carried out. Single thyroid nodules and dominant nodules of multinodular goiter were included. Patients who had undergone thyroid surgery in the past were excluded. All patients underwent a high-resolution ultrasound and elastography, and, subsequently, a FNAB. We analyzed the ultrasound variables in 2D and Doppler, followed by the elastographic variables, and the results of the FNAB according to Bethesda. To correlate the data, the nodules were classified as benign or malignant. Student's t test, the Chi-square test and a logistic regression analysis were applied for the statistical analysis. RESULTS: A total of 221 thyroid nodules were analyzed, 32 of which were malignant (14%). The most predictive ultrasound findings of malignancy (P<.05) were a hypoechoic or complex echostructure (OR=11.832), the presence of microcalcifications (OR=9.637) and chaotic vascularization observed in the Doppler (OR=46.464). With regard to the elastography, elastographic patterns i and ii were seen to be associated with benignity (P=.0004 and P<.0001, respectively). When type i or ii elastography was combined with an ultrasound showing a non-hypoechoic nor complex echostructure, without microcalcifications nor chaotic vascularization in the Doppler ultrasound, 100% of the cases were benign with a specificity of 100% and a sensitivity of 14%. CONCLUSIONS: The combination of a high-resolution ultrasound with an elastography makes it possible to select cases where a FNAB does not have to be performed. Cases susceptible to a periodic follow-up without the use of a FNAB are those without a hypoechoic nor complex structure, no microcalcifications, non-chaotic vascularization and a type i or ii elastography.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171103
[Lr] Last revision date:171103
[St] Status:Publisher

  2 / 7943 MEDLINE  
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[PMID]: 29017861
[Au] Autor:Alramadhan M; Choe JH; Lee JH; Kim JH; Kim JS
[Ad] Address:Department of Surgery, King Saud Medical City, Riyadh, Saudi Arabia.
[Ti] Title:Propensity score-matched analysis of the endoscopic bilateral axillo-breast approach (BABA) versus conventional open thyroidectomy in patients with benign or intermediate fine-needle aspiration cytology results, a retrospective study.
[So] Source:Int J Surg;48:9-15, 2017 Oct 07.
[Is] ISSN:1743-9159
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: The purpose of this study was to compare the surgical outcomes of endoscopic bilateral axillo-breast approach (BABA) to conventional open thyroidectomy (COT) in patients who had thyroid nodule(s) with a benign or intermediate fine-needle aspiration cytology (FNAC) results. MATERIALS AND METHODS: All patients with benign or intermediate thyroid nodule(s) who underwent BABA (n = 95) or COT (n = 262) between 2008 and 2015 were reviewed. Then, 1:1 propensity score matching was performed, and 66 matched pairs were obtained. Surgical outcomes were then compared. RESULTS: Before matching, patients in the BABA group were significantly younger (36.5 vs. 50.7 years, p < 0.000), predominantly female (97.9% vs. 69.8%, p < 0.000), had smaller tumours (2.1 vs. 2.8 cm, p = 0.002) and more commonly underwent hemithyroidectomy (88.4% vs. 70.6%, p < 0.000) than those in the COT group. After matching, all clinicopathological characteristics were equivalent. BABA was found to be significantly associated with longer operative time (125.3 vs. 79.8 min, p < 0.000), greater drainage volume (132.9 vs. 59.1 ml, p < 0.000), longer postoperative hospital stay (3.1 vs. 2.2 days, p < 0.000), and higher average total medical expense (4000 vs. 3200 US$). However, the incidence of complications did not differ between the groups. CONCLUSION: BABA is comparable to COT in terms of complications and is safe and feasible when performed by experienced surgeons and for carefully selected patients who are concerned about neck scarring. However, the operative time and postoperative hospital stay are significantly longer, which may increase medical expenses.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171103
[Lr] Last revision date:171103
[St] Status:Publisher

  3 / 7943 MEDLINE  
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[PMID]: 28991565
[Au] Autor:Li Q; Lin X; Shao Y; Xiang F; Samir AE
[Ad] Address:Department of Radiology, Massachusetts General Hospital, Harvard Medical School, White 270, 55 Fruit Street, Boston, MA 02114, USA.
[Ti] Title:Imaging and Screening of Thyroid Cancer.
[So] Source:Radiol Clin North Am;55(6):1261-1271, 2017 Nov.
[Is] ISSN:1557-8275
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Ultrasound is the first-line diagnostic tool for diagnosis of thyroid diseases. The low aggressiveness of many thyroid cancers coupled with high sensitivity of sonography can lead to cancer diagnosis and treatment with no effect on outcomes. Ultrasound is recognized as the most important driver of thyroid cancer overdiagnosis. Ultrasound should not be used as a general screening tool and should be reserved for patients at high risk of thyroid cancer and in the diagnostic management of incidentally discovered thyroid nodules. With prescreening risk stratification and application of consensus criteria for nodule biopsy, the value of the diagnostic ultrasound can be maximized.
[Mh] MeSH terms primary: Thyroid Neoplasms/diagnostic imaging
[Mh] MeSH terms secundary: Humans
Incidental Findings
Thyroid Gland/diagnostic imaging
Thyroid Nodule/diagnostic imaging
Ultrasonography
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1711
[Cu] Class update date: 171102
[Lr] Last revision date:171102
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:171009
[St] Status:MEDLINE

  4 / 7943 MEDLINE  
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[PMID]: 28127743
[Au] Autor:Gelsomino F; Lamberti G; Ambrosini V; Sperandi F; Agosti R; Morganti AG; Ardizzoni A
[Ad] Address: Medical Oncology Unit, Policlinico S. Orsola-Malpighi, Bologna - Italy.
[Ti] Title:Metachronous solitary metastasis to the thyroid gland from squamous cell carcinoma of the lung: a case report and literature review.
[So] Source:Tumori;:0, 2017 Jan 23.
[Is] ISSN:2038-2529
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Non-small cell lung cancer presents at an advanced stage at diagnosis in two-thirds of cases. The most frequent metastatic sites are the central nervous system, adrenal glands and bones. By contrast, the thyroid gland is an extremely rare site of dissemination. CASE DESCRIPTION: A 64-year-old Caucasian man previously treated with radiosurgery and brain metastasectomy followed by right middle lobectomy for a squamous cell lung carcinoma had a metachronous solitary metastasis to the thyroid gland, as confirmed by fine-needle aspiration cytology and open biopsy. He underwent curative radiotherapy, with an initial response. At 9 months' follow-up the tumor relapsed both in the thyroid and the lung. DISCUSSION AND CONCLUSIONS: Review of the literature confirmed that thyroid metastasis from lung cancer is very uncommon in clinical practice. No data on the role of surgery or curative radiotherapy in thyroid metastasis are available because of the lack of prospective studies addressing the impact on survival of these treatment strategies either alone or in combination. In the case described here, radical treatment with radiotherapy allowed to obtain a modest benefit in terms of relapse-free survival. A diagnosis of metastasis to the thyroid gland should be suspected in patients who present a thyroid nodule or suggestive imaging findings when there is a history of malignancy, including lung cancer. Indeed, an early diagnosis allows to pursue radical treatment that, in selected patients, could lead to long-term survival.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1701
[Cu] Class update date: 171103
[Lr] Last revision date:171103
[St] Status:Publisher

  5 / 7943 MEDLINE  
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[PMID]: 29091005
[Au] Autor:Park CJ; Kim EK; Moon HJ; Yoon JH; Park VY; Kwak JY
[Ad] Address:1 Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.
[Ti] Title:Thyroid Nodules With Nondiagnostic Cytologic Results: Follow-Up Management Using Ultrasound Patterns Based on the 2015 American Thyroid Association Guidelines.
[So] Source:AJR Am J Roentgenol;:1-6, 2017 Nov 01.
[Is] ISSN:1546-3141
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: The purpose of this study was to evaluate the malignancy rate of nodules with nondiagnostic cytologic results based on the American Thyroid Association (ATA) ultrasound (US) patterns and to suggest management guidelines for these nodules. MATERIALS AND METHODS: From January 2013 to December 2014, 441 nodules (≥ 1 cm) were found in 437 patients with nondiagnostic results of ultrasound (US)-guided fine-needle aspiration biopsy (nondiagnostic nodules). A total of 191 nodules that were cytopathologically confirmed or were smaller (> 3 mm) at follow-up US were enrolled. The US findings of each nodule were reviewed. One radiologist classified the nodules into the following five categories according to the 2015 ATA guidelines: high, intermediate, low, and very low suspicion for malignancy and benign. The reference standard was histopathologic confirmation. Nodules that were smaller at follow-up US were considered benign. The malignancy rate of each category was calculated. RESULTS: Among a total 191 nodules, 20 (10.5%) were malignant. Solid composition, marked hypoechogenicity, microlobulated or irregular margins, microcalcifications, and taller-than-wide shape were more frequently seen in malignant nodules (all p < 0.001). The malignancy rate of nodules with very low suspicion of malignancy was 0% (0/58); low, 0% (0/45); intermediate, 10.3% (6/58); and high, 46.7% (14/30) (p < 0.001). CONCLUSION: When US findings of thyroid nodules are assessed according to the 2015 ATA guidelines, nondiagnostic thyroid nodules with very-low- or low-suspicion US patterns can be followed up with US. Nondiagnostic nodules with intermediate or highly suspicious US patterns should be evaluated with repeat US-guided fine-needle aspiration biopsy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171101
[Lr] Last revision date:171101
[St] Status:Publisher
[do] DOI:10.2214/AJR.17.18532

  6 / 7943 MEDLINE  
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[PMID]: 29068996
[Au] Autor:Hu X; Liu Y; Qian L
[Ad] Address:Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
[Ti] Title:Diagnostic potential of real-time elastography (RTE) and shear wave elastography (SWE) to differentiate benign and malignant thyroid nodules: A systematic review and meta-analysis.
[So] Source:Medicine (Baltimore);96(43):e8282, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Real-time elastography (RTE) and shear wave elastography (SWE) are noninvasive and easily available imaging techniques that measure the tissue strain, and it has been reported that the sensitivity and the specificity of elastography were better in differentiating between benign and malignant thyroid nodules than conventional technologies. METHODS: Relevant articles were searched in multiple databases; the comparison of elasticity index (EI) was conducted with the Review Manager 5.0. Forest plots of the sensitivity and specificity and SROC curve of RTE and SWE were performed with STATA 10.0 software. In addition, sensitivity analysis and bias analysis of the studies were conducted to examine the quality of articles; and to estimate possible publication bias, funnel plot was used and the Egger test was conducted. RESULTS: Finally 22 articles which eventually satisfied the inclusion criteria were included in this study. After eliminating the inefficient, benign and malignant nodules were 2106 and 613, respectively. The meta-analysis suggested that the difference of EI between benign and malignant nodules was statistically significant (SMD = 2.11, 95% CI [1.67, 2.55], P < .00001). The overall sensitivities of RTE and SWE were roughly comparable, whereas the difference of specificities between these 2 methods was statistically significant. In addition, statistically significant difference of AUC between RTE and SWE was observed between RTE and SWE (P < .01). CONCLUSION: The specificity of RTE was statistically higher than that of SWE; which suggests that compared with SWE, RTE may be more accurate on differentiating benign and malignant thyroid nodules.
[Mh] MeSH terms primary: Elasticity Imaging Techniques/methods
Thyroid Gland/diagnostic imaging
Thyroid Neoplasms/pathology
Thyroid Nodule/pathology
[Mh] MeSH terms secundary: Diagnosis, Differential
Humans
Sensitivity and Specificity
[Pt] Publication type:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Entry month:1711
[Cu] Class update date: 171101
[Lr] Last revision date:171101
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:171025
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008282

  7 / 7943 MEDLINE  
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[PMID]: 29017314
[Au] Autor:Cha YJ; Pyo JY; Hong SW; Seok JY; Kim KJ; Han JY; Bae JM; Kwon HJ; Kim Y; Min KW; Oak S; Chang S
[Ad] Address:Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
[Ti] Title:Thyroid Fine Needle Aspiration Cytology Practice in Korea.
[So] Source:J Pathol Transl Med;, 2017 10 11.
[Is] ISSN:2383-7837
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:We reviewed the current status of thyroid fine needle aspiration cytology (FNAC) in Korea. Thyroid aspiration biopsy was first introduced in Korea in 1977. Currently, radiologists aspirate the thyroid nodule under the guidance of ultrasonography, and cytologic interpretation is only legally approved when a cytopathologist makes the diagnosis. In 2008, eight thyroid-related societies came together to form the Korean Thyroid Association. The Korean Society for Cytopathology and the endocrine pathology study group of the Korean Society for Pathologist have been updating the cytologic diagnostic guidelines. The Bethesda System for Reporting Thyroid Cytopathology was first introduced in 2009, and has been used by up to 94% of institutions by 2016. The average diagnosis rates are as follows for each category: I (12.4%), II (57.9%), III (10.4%), IV (2.9%), V (3.7%), and VI (12.7%). The malignancy rates in surgical cases are as follows for each category: I (28.7%), II (27.8%), III (50.6%), IV (52.3%), V (90.7%), and VI (100.0%). Liquid-based cytology has been used since 2010, and it was utilized by 68% of institutions in 2016. The categorization of thyroid lesions into "atypia of undetermined significance" or "follicular lesion of undetermined significance" is necessary to draw consensus in our society. Immunocytochemistry for galectin-3 and BRAF is used. Additionally, a molecular test for BRAF in thyroid FNACs is actively used. Core biopsies were performed in only 44% of institutions. Even the institutions that perform core biopsies only perform them for less than 3% of all FNACs. However, only 5% of institutions performed core biopsies up to three times more than FNAC.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171102
[Lr] Last revision date:171102
[St] Status:Publisher
[do] DOI:10.4132/jptm.2017.09.26

  8 / 7943 MEDLINE  
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[PMID]: 28982301
[Au] Autor:Eszlinger M; Ullmann M; Ruschenburg I; Böhme K; Görke F; Franzius C; Adam S; Molwitz T; Landvogt C; Amro B; Hach A; Feldmann B; Graf D; Wefer A; Niemann R; Bullmann C; Klaushenke G; Santen R; Tönshoff G; Ivancevic V; Kögler A; Bell E; Lorenz B; Kluge G; Hartenstein C; Paschke R
[Ad] Address:1 Departments of Oncology, Pathology and Laboratory Medicine, Biochemistry and Molecular Biology, and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada .
[Ti] Title:Low Malignancy Rates in Fine-Needle Aspiration Cytologies in a Primary Care Setting in Germany.
[So] Source:Thyroid;27(11):1385-1392, 2017 Nov.
[Is] ISSN:1557-9077
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Reported results for thyroid nodule fine-needle aspiration (FNA) cytology mainly originate from tertiary centers. However, thyroid nodule FNA cytology is mainly performed in primary care settings for which the distribution of FNA Bethesda categories and their respective malignancy rates are largely unknown. Therefore, this study investigated FNA cytology malignancy rates of a large primary care setting to determine to what extent current evidence-based strategies for the malignancy risk stratification of thyroid nodules are applied and applicable in such primary care settings. METHODS: In a primary care setting, 9460 FNAs of thyroid nodules were retrospectively analyzed from 8380 patients evaluated by one cytologist (I.R.) during a period of two years. The 8380 FNA cytologies were performed by 64 physicians in different private practices throughout Germany in primary care settings. RESULTS: The cytopathologic results were classified according to the Bethesda System as non-diagnostic in 19%, cyst/cystic nodule in 21%, benign (including thyroiditis) in 48%, atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) in 6%, follicular neoplasms/suspicious for follicular neoplasm (FN/SFN) in 4%, suspicious for malignancy (SFM) in 1%, and malignant in 1%. The proportion of patients proceeding to surgery or with a follow-up of at least one year and the observed risks of malignancy were 22%/8% for AUS/FLUS, 69%/17% for FN/SFN, 78%/86% for SFM, and 71%/98% for malignant. For 112 cytologically suspicious and malignant FNAs, there were 102 true positives and 10 false positives, considering histology as gold standard. CONCLUSION: At variance with other data mostly originating from tertiary centers, these data demonstrate low percentages for malignant, SFM, FN/SFN, and AUS/FLUS, and high percentages for cysts/cystic nodules in this primary care setting in Germany. The risks of malignancy for malignant, SFM, AUS/FLUS, and FN/SFN FNA cytologies are according to Bethesda recommendations.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171101
[Lr] Last revision date:171101
[St] Status:In-Process
[do] DOI:10.1089/thy.2017.0167

  9 / 7943 MEDLINE  
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[PMID]: 28982296
[Au] Autor:Bardet S; Ciappuccini R; Pellot-Barakat C; Monpeyssen H; Michels JJ; Tissier F; Blanchard D; Menegaux F; de Raucourt D; Lefort M; Reznik Y; Rouxel A; Heutte N; Brenac F; Leconte A; Buffet C; Clarisse B; Leenhardt L
[Ad] Address:1 Department of Nuclear Medicine and Thyroid Unit, Centre François Baclesse , Caen, France .
[Ti] Title:Shear Wave Elastography in Thyroid Nodules with Indeterminate Cytology: Results of a Prospective Bicentric Study.
[So] Source:Thyroid;27(11):1441-1449, 2017 Nov.
[Is] ISSN:1557-9077
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: The clinical management of thyroid nodules with indeterminate cytology (IC) remains challenging. The role of shear wave elastography (SWE) in this setting is controversial. The aim of the study was to assess the performances of SWE in terms of prediction of malignancy, reproducibility, and combined analysis with ultrasound (US) examination in thyroid nodules with IC. METHODS: This prospective study was conducted in two referral centers. Eligible patients had a thyroid nodule ≥15 mm with IC (Bethesda class III-V) for which surgery had been recommended. Patients underwent a standardized US evaluation combined with a SWE exam followed by surgery. SWE parameters included mean (meanEI; kPa) and max (maxEI) elasticity values, and ratio (meanEI nodule/parenchyma). RESULTS: One hundred and thirty-one nodules (median size 30 mm) in 131 patients were studied. IC was class III in 28%, class IV in 64%, and class V in 8% of cases. After surgery, 21 (16%) nodules were malignant, including nine papillary thyroid cancers (PTC), six follicular thyroid cancers, five poorly differentiated carcinomas, and one large B-cell lymphoma. SWE parameters were similar in benign and malignant nodules, including meanEI (20.2 vs. 19.6 kPa), maxEI (34.3 vs. 32.5 kPa), and ratio (1.57 vs. 1.38). In malignant nodules, meanEI, maxEI, and ratio were higher in the classic PTC variants (n = 4) than in the other PTC variants (n = 5; p < 0.02) and in non-PTC tumors (n = 12; p < 0.005). Intra- and inter-observer coefficients of variations for meanEI in nodules were 23% and 26%, respectively. The French Thyroid Imaging Reporting and Data System score, the American Thyroid Association US classification, and the EU-Thyroid Imaging Reporting and Data System were not associated with malignancy. CONCLUSIONS: Despite high elasticity values in classic PTC variants, conventional SWE indexes failed to discriminate between benign and malignant tumors in thyroid nodules with IC.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171101
[Lr] Last revision date:171101
[St] Status:In-Process
[do] DOI:10.1089/thy.2017.0293

  10 / 7943 MEDLINE  
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[PMID]: 28927353
[Au] Autor:Cano JM; Galán R; López R
[Ad] Address:Department of Medical Oncology, Hospital General de Ciudad Real , Ciudad Real, Spain .
[Ti] Title:Recurrent Metastatic Medullary Thyroid Carcinoma: A Case of Sustained Response to Prolonged Treatment with Somatostatin Analogues.
[So] Source:Thyroid;27(11):1450-1455, 2017 Nov.
[Is] ISSN:1557-9077
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Medullary thyroid carcinoma (MTC) is a rare disease. Treatment options for recurrent disease are limited. Although somatostatin analogues might have a role as anticancer agents in MTC, the evidence is inconclusive. PATIENT FINDINGS: A 64-year-old male was diagnosed with MTC in January 2010. Total thyroidectomy with neck dissection (stage IVA, pT2pN1bM0, R1) was performed, followed by adjuvant locoregional radiotherapy. Two years later, in January 2012, the patient developed recurrent metastatic disease, evidenced by elevated carcinoembryonic antigen (CEA) and calcitonin levels, and a positive uptake (Octreoscan ) in the right adrenal gland and pancreatic head. A further computed tomography (CT) scan revealed metastases in the right adrenal gland, the duodenal bulb, and two pancreatic lesions, which were later confirmed as metastases by endoscopic ultrasound and cytology, and therefore salvage surgery was ruled out. Treatment with Somatuline Autogel (120 mg subcutaneously every 28 days) was initiated in September 2012, and 11 months later, calcitonin and CEA levels had both normalized, and a new CT scan showed that the metastatic lesions had disappeared or shrunk markedly. An Octreoscan performed in January 2014 and a repeat contrast-enhanced CT in February 2014 showed sustained tumor response. The patient remained in remission until February 2016, when a new Octreoscan revealed recurrent disease in the right adrenal gland, a nodule in the right upper pulmonary lobe, and nodal disease in the celiac trunk. CEA and calcitonin levels remained normal, although with a slight increase in calcitonin levels (47 pg/mL). SUMMARY: The unusual case is described of a patient with metastatic MTC involving the adrenal gland, duodenum, and pancreas, who achieved a sustained response to somatostatin analogues after 11 months of treatment. The patient remained in remission for nearly 3.5 years from initiation of treatment with somatostatin analogues. CONCLUSIONS: The case presented here is one of the few described in the literature in which long-term treatment with somatostatin analogues resulted in a sustained tumor response in a patient with metastatic recurrent MTC following curative-intent surgery. These findings suggest that prolonged treatment with somatostatin analogues may be beneficial in asymptomatic cases with a low tumor burden and a positive Octreoscan following recurrence. More data are needed to confirm these findings.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 171101
[Lr] Last revision date:171101
[St] Status:In-Process
[do] DOI:10.1089/thy.2016.0540


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