Database : MEDLINE
Search on : Trichomonas and Infections [Words]
References found : 4406 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 441 go to page                         

  1 / 4406 MEDLINE  
              next record last record
select
to print
Photocopy

[PMID]: 29376609
[Au] Autor:Chubukova OA; Shkarin VV
[Ad] Address:Nizhny Novgorod State Medical Academy of Minzdrav of Russia, Nizhny Novgorod, Russia.
[Ti] Title:[Concomitant urogenital infections in men].
[So] Source:Urologiia;(6):126-130, 2017 Dec.
[Is] ISSN:1728-2985
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:The article presents possible combinations of urogenital infections of various etiologies and some pathogenetic, clinical and epidemiological features, and issues of epidemiological surveillance for co-infection. The authors describe in detail combinations with each other and with other diseases of such pathogens as Chlamydia trachomatis, Ureaplasma urealyticum, Mycoplasma spp., Neisseria gonorrhoeae, Trichomonas vaginalis. They also focus on the problem of co-occurrence of human papillomavirus (HPV) with other urogenital pathogens. The article raises the question of the need to introduce new scientific data on the epidemiology of concomitant urogenital infections in men in the practice of diagnosis, treatment, registration, and implementation of preventive and anti-epidemic measures.
[Mh] MeSH terms primary: Coinfection
Gram-Negative Bacterial Infections
Papillomavirus Infections
Urinary Tract Infections
[Mh] MeSH terms secundary: Coinfection/diagnosis
Coinfection/microbiology
Coinfection/therapy
Coinfection/virology
Gram-Negative Bacterial Infections/diagnosis
Gram-Negative Bacterial Infections/microbiology
Gram-Negative Bacterial Infections/therapy
Gram-Negative Bacterial Infections/virology
Humans
Male
Papillomavirus Infections/diagnosis
Papillomavirus Infections/microbiology
Papillomavirus Infections/therapy
Urinary Tract Infections/diagnosis
Urinary Tract Infections/microbiology
Urinary Tract Infections/therapy
Urinary Tract Infections/virology
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:180130
[St] Status:MEDLINE

  2 / 4406 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29505113
[Au] Autor:Barry MS; Diallo AB; Diadhiou M; Mall I; Gassama O; Guèye MDN; Covi-Alavo S; Gawa E; Fall AN; Diallo AG; Moreau JC
[Ad] Address:Laboratoires SANOFI Afrique Subsaharienne Francophone, Dakar, Sénégal.
[Ti] Title:Infections among symptomatic women of reproductive age attending primary care clinics in Dakar, Senegal.
[So] Source:Trop Med Int Health;, 2018 Mar 05.
[Is] ISSN:1365-3156
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To assess the effectiveness of the WHO syndromic algorithm in the management of vaginal discharge among women of reproductive age in Dakar. METHODS: Cross-sectional study of consecutive female patients (aged 18-49 years) presenting with vaginal symptoms at six selected study sites in Dakar; of these, 276 patients were included in the analysis. Vaginal and cervical swab samples were collected and analysed to establish an aetiological diagnosis of any infection. Syndrome-based diagnosis was compared with the laboratory results to evaluate its accuracy based on sensitivity, specificity and positive and negative predictive values. The degree of agreement between the two approaches was assessed using the Cohen's kappa concordance analysis. RESULTS: Overall prevalence of vaginal infections was 56.9% (157/276); 5.4% (15/276) of the patients had cervical infection. Using the syndromic approach, 51% of patients were correctly managed for Trichomonas vaginalis (TV)/Gardnerella vaginalis (GV); 61% for Candida albicans (CA) and 54% for Chlamydia trachomatis (CT)/Neisseria gonorrhoea (NG) infections. Consequently, 31% of patients with TV/GV, 51% with CA and 53% with CT/NG infections would have missed treatment. Further, the kappa value was <0.20, indicating that there was no agreement or only slight agreement between the syndromic approach and laboratory-based diagnosis. CONCLUSION: This study highlights the limitations of the applicability of the WHO syndromic approach in settings with low prevalence of sexually transmitted infections (STIs) and calls for affordable and accurate rapid tests for STIs. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:Publisher
[do] DOI:10.1111/tmi.13046

  3 / 4406 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29474232
[Au] Autor:Ferreira CST; da Silva MG; de Pontes LG; Dos Santos LD; Marconi C
[Ad] Address:Department of Pathology from Botucatu Medical School (FMB), São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
[Ti] Title:Protein Content of Cervicovaginal Fluid Is Altered During Bacterial Vaginosis.
[So] Source:J Low Genit Tract Dis;, 2018 Feb 28.
[Is] ISSN:1526-0976
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVES: The aim of the study was to compare, using a proteomic approach, cervicovaginal fluid (CVF) proteins of women with bacterial vaginosis (BV) with those presenting normal microbiota. MATERIALS AND METHODS: A total of 309 reproductive-aged women were cross-sectionally enrolled. Participants were tested for vaginal candidosis, Trichomonas vaginalis, Chlamydia trachomatis, and Neisseria gonorrhoeae and excluded if positive. Vaginal microbiota was classified microscopically according to Nugent criteria in normal, intermediate, and BV. Randomly selected CVF samples of 29 women with BV and an equal number with normal microbiota were subjected to proteomic analysis. Thus, a total of 58 CVF samples were evaluated using shotgun liquid chromatography-tandem mass spectrometry in a Q-Tof PREMIER API mass spectrometer (MicroMass/Waters) for peptide detection and relative quantification. RESULTS: Of the 309 women enrolled, 63 (20.4%) were excluded after testing positive for at least one of the tested co-infections or because of low-quality samples. Microscopic classification of vaginal microbiota on the remaining 246 samples revealed that 132 women (53.6%) had normal microbiota, 33 (13.4%) had intermediate microbiota, and 81 (33.0%) had BV. Proteomic analysis of CVF of 58 randomly selected women with normal microbiota (n = 29) or BV (n = 29) successfully identified 74 proteins. In addition, the comparison of abundance of those proteins between the groups showed that the following five (6.7%) were enriched in BV: neutrophil elastase, kaliocin-1, neutrophil defensin-1, Ig lambda-2 chain C regions, and protein S100-A7. All of which have a recognized role in host's immunity. CONCLUSIONS: Exclusive finding of BV affects immunity-related CVF components of reproductive-aged women.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[St] Status:Publisher
[do] DOI:10.1097/LGT.0000000000000367

  4 / 4406 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29368037
[Au] Autor:Fürnkranz U; Henrich B; Walochnik J
[Ad] Address:Institute of Specific Prophylaxis and Tropical Medicine, Centre for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Kinderspitalgasse 15, A-1090, Vienna, Austria. ursula.fuernkranz@meduniwien.ac.at.
[Ti] Title:Mycoplasma hominis impacts gene expression in Trichomonas vaginalis.
[So] Source:Parasitol Res;117(3):841-847, 2018 Mar.
[Is] ISSN:1432-1955
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:In Europe, up to 90% of isolated Trichomonas vaginalis strains are naturally infected with Mycoplasma hominis, a facultative pathogen of the human genital tract. The consequences of this endosymbiosis are not yet well understood. The aim of the current study was to evaluate the impact of natural and artificial infections with M. hominis on the RNA expression levels of metronidazole susceptibility-associated genes of T. vaginalis. Three T. vaginalis strains (TVSS10-, TVSS25-, G3) without M. hominis, as well as the same strains naturally (TVSS10+, TVSS25+) and artificially (G3-MhSS25, TVSS25-MhSS25) infected with M. hominis, were investigated for their expression profiles of three genes associated with metronidazole resistance (ferredoxin, flavin reductase 1 and pyruvate:ferredoxin oxidoreductase). The minimal inhibitory concentrations (MICs) of metronidazole were evaluated for all combinations and the respective M. hominis-free T. vaginalis strains were used as controls. The sole presence of M. hominis led to a down-regulation of metronidazole susceptibility-associated genes in all T. vaginalis strains tested. Interestingly, the effect was more prominent in the artificial symbioses. Moreover, a twofold enhancement of metronidazole tolerability was observed in three infected T. vaginalis strains, compared to the respective strains without M. hominis. In conclusion, M. hominis had an impact on gene expression in all T. vaginalis strains and on metronidazole MIC in all but one strain tested.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:In-Process
[do] DOI:10.1007/s00436-018-5761-6

  5 / 4406 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29465686
[Au] Autor:Price CM; Peters RPH; Steyn J; Mudau M; Olivier D; De Vos L; Morikawa E; Kock MM; Medina-Marino A; Klausner JD
[Ad] Address:David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States of America 90095 Department of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa and Anova Health Institute, Johannesburg, South Africa 2193 Department of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa 0002 Research Unit, Foundation for Professional Development, Pretoria, South Africa 0184 Research Unit, Foundation for Professional Development, Pretoria, South Africa 0184 Research Unit, Foundation for Professional Development, Pretoria, South Africa 0184 David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States of America 90095 Department of Medical Microbiology, Tshwane Academic Division, National Health Laboratory Service and Department of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa 0002 Research Unit, Foundation for Professional Development, Pretoria, South Africa and School of Health Systems and Public Health, University of Pretoria, Pretoria, South Africa 0184 Division of Infectious Disease, Department of Medicine, University of California, Los Angeles, Los Angeles, California, United States of America 90024.
[Ti] Title:Prevalence and Detection of Trichomonas vaginalis in Human Immunodeficiency Virus-Infected Pregnant Women.
[So] Source:Sex Transm Dis;, 2017 Nov 07.
[Is] ISSN:1537-4521
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Trichomonas vaginalis is a STI associated with increased transmission of HIV and significant adverse birth outcomes; culture and PCR are commonly used in diagnosis. METHODS: Consenting HIV-infected pregnant women were recruited from clinics in South Africa and screened for T. vaginalis using PCR. PCR-positive women provided an additional sample for culture. We compared T. vaginalis detection between PCR and culture, and investigated how PCR cycle threshold (Ct) values differ among culture results. RESULTS: A total of 359 women were enrolled and 76 (20%) tested T. vaginalis PCR-positive. Cultures were obtained from 61 of the PCR-positive women, and 38 (62%) were culture-positive. The median baseline Ct of the PCR-positive/culture-positive group was 22.6 vs. 38.0 among those PCR-positive/culture-negative (p<0.001). Culture positive cases had lower Ct values (higher DNA load); a Ct value < 30 predicted positivity with a sensitivity of 97% and specificity of 96%. CONCLUSIONS: Culture was positive in roughly half of PCR positive cases. The culture-negative cases had significantly higher Ct values, indicating a lower concentration of T. vaginalis DNA. A Ct value of 30 provides a reliable threshold for predicting culture positivity. The clinical significance of culture-negative infections detected by PCR is still unclear.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180227
[Lr] Last revision date:180227
[St] Status:Publisher
[do] DOI:10.1097/OLQ.0000000000000756

  6 / 4406 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29471763
[Au] Autor:Davis A; Goddard-Eckrich D; Dasgupta A; El-Bassel N
[Ad] Address:1 HIV Center, Division of Gender, Sexuality, & Health, New York State Psychiatric Institute and 21611 Columbia University Medical Center , New York, NY, USA.
[Ti] Title:Risk factors associated with sexually transmitted infections among women under community supervision in New York City.
[So] Source:Int J STD AIDS;:956462418755223, 2018 Jan 01.
[Is] ISSN:1758-1052
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The number of women under community supervision in the United States has increased, and this population has a high risk for sexually transmitted infections (STIs). We examined STI prevalence and multiple risk factors among drug-involved women under community supervision in New York City. Data were from a randomized controlled trial testing the efficacy of a behavioral HIV/STI intervention (Women on the Road to Health [WORTH]) among drug-involved women in the community corrections system in New York City from 2009 to 2012. To be eligible for inclusion, women had to be under community supervision within the past 90 days, have used illicit drugs at least once in the past six months, and have unprotected sex at least once in the past 90 days. Participants completed a survey containing items on STI risk factors and were tested for Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis. Multivariable regression was used to examine associations between risk factors and STI diagnosis. Of 333 women tested, 89 (26.7%) tested positive for an STI. Ten (3.0%) were positive for C. trachomatis, 4 (1.2%) for N. gonorrhoeae, and 77 (23.1%) for T. vaginalis. Women with any STI were more likely to be black (AOR: 2.02; 95% CI: 1.08-3.77), homeless in the past 90 days (AOR: 2.07; 95% CI: 1.01-4.26), arrested in the past 90 days (AOR: 1.97; 95% CI: 1.14-3.39), and have a greater number of sexual partners in the past 90 days (AOR: 1.24; 95% CI: 1.08-1.42). Drug-using women under community supervision have a high burden of STIs driven by multiple risk factors. Implementing STI screening, prevention, and treatment programs in community supervision settings could facilitate a reduction in STIs among this population.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180223
[Lr] Last revision date:180223
[St] Status:Publisher
[do] DOI:10.1177/0956462418755223

  7 / 4406 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29465674
[Au] Autor:Chirenje ZM; Dhibi N; Handsfield HH; Gonese E; Barr BT; Gwanzura L; Latif AS; Maseko DV; Kularatne RS; Tshimanga M; Kilmarx PH; Machiha A; Mugurungi O; Rietmeijer CA
[Ad] Address:University of Zimbabwe College of Health Sciences - Clinical Trial Unit, 15 Phillips, Belgravia, Harare, Zimbabwe.
[Ti] Title:The Etiology of Vaginal Discharge Syndrome in Zimbabwe Results from the Zimbabwe STI Etiology Study.
[So] Source:Sex Transm Dis;, 2017 Nov 29.
[Is] ISSN:1537-4521
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Symptomatic vaginal discharge is a common gynecological condition managed syndromically in most developing countries. In Zimbabwe, women presenting with symptomatic vaginal discharge are treated with empirical regimens that commonly cover both sexually transmitted infections (STI) and reproductive tract infections, typically including a combination of an intramuscular injection of kanamycin, and oral doxycycline and metronidazole regimens. This study was conducted to determine the current etiology of symptomatic vaginal discharge and assess adequacy of current syndromic management guidelines. METHODS: We enrolled 200 women with symptomatic vaginal discharge presenting at 6 STI clinics in Zimbabwe. Microscopy was used to detect bacterial vaginosis and yeast infection. Nucleic acid amplifications tests were used to detect Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis and Mycoplasma genitalium. In addition, serologic testing was performed to detect HIV infection. RESULTS: Of the 200 women, 146 (73%) had an etiology detected, including bacterial vaginosis (24.7%); N. gonorrhoeae (24.0%); yeast infection (20.7%); T. vaginalis (19.0%); C. trachomatis (14.0%) and M. genitalium (7.0%). Among women with STIs (N=90), 62 (68.9%) had a single infection, 18 (20.0%) had a dual infection and 10 (11.1%) had three infections.Of 158 women who consented to HIV testing, 64 (40.5%) were HIV infected.The syndromic management regimen covered 115 (57.5%) of the women in the sample who had gonorrhea, chlamydia, M. genitalium, or bacterial vaginosis, while 85 (42.5%) of women were treated without such diagnosis. CONCLUSION: Among women presenting with symptomatic vaginal discharge, bacterial vaginosis was the most common etiology and gonorrhea was the most frequently detected STI. The current syndromic management algorithm is suboptimal for coverage of women presenting with symptomatic vaginal discharge; addition of point of care testing could compliment the effectiveness of the syndromic approach.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180221
[Lr] Last revision date:180221
[St] Status:Publisher
[do] DOI:10.1097/OLQ.0000000000000771

  8 / 4406 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29465667
[Au] Autor:Lockhart A; Psioda M; Ting J; Campbell S; Mugo N; Kwatampora J; Chitwa M; Kimani J; Gakure A; Smith JS
[Ad] Address:Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, North Carolina.
[Ti] Title:Prospective Evaluation Of Cervico-Vaginal Self And Cervical Physician-Collection For The Detection Of Chlamydia Trachomatis, Neisseria Gonorrhoeae, Trichomonas Vaginalis, And Mycoplasma Genitalium Infections.
[So] Source:Sex Transm Dis;, 2018 Jan 02.
[Is] ISSN:1537-4521
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: To examine the agreement between sexually transmitted infection (STI) screening using self-collected specimens and physician-collected specimens, and to investigate the acceptability of self-collection for screening in an 18-month study of female sex-workers (FSW) in a high-risk, low-resource setting. METHODS: A total of 350 FSW in Nairobi, Kenya participated in a prospective study from 2009-2011. Women self-collected a cervico-vaginal specimen. Next, a physician conducted a pelvic examination to obtain a cervical specimen. Physician- and self-collected specimens were tested for Chlamydia trachomatis (CT), Neisseria gonorrhoeae (GC), Trichomonas vaginalis (TV) and Mycoplasma genitalium (MG) using Aptima nucleic acid amplification assays (Hologic). Specimens were collected at three-month intervals over 18-months follow-up. Kappa statistics measured agreement of positivity between self- and physician-collection. RESULTS: Baseline STI prevalence was 2.9% for GC, 5.2% for CT, 9.2% for TV, and 20.1% for MG in self-collected samples, and 2.3%, 3.7%, 7.2%, and 12.9% respectively in physician-collected samples. Kappa agreement was consistently strong (range 0.66-1.00) for all STIs over the 18-month study period, except MG which had moderate agreement (range: 0.50-0.75). Most participants found self-collection easy (94%) and comfortable (89%) at baseline, with responses becoming modestly more favorable over time. DISCUSSION: Self-collected specimens screening results showed strong agreement to clinical-collected specimens, except MG which was consistently detected more commonly in self- than physician-collected specimens. Acceptability of the self-collection procedure was high at baseline and increased modestly over time. In high-risk, low-resource settings, STI screening with self-collected specimens provides a reliable and acceptable alternative to screening with physician-collected specimens.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180221
[Lr] Last revision date:180221
[St] Status:Publisher
[do] DOI:10.1097/OLQ.0000000000000778

  9 / 4406 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy

[PMID]: 29415533
[Au] Autor:Korycinska J; Dzika E; Wasniewski T; Lepczynska M; Kubiak K
[Ti] Title:The prevalence of Trichomonas vaginalis infections in the population of Warminsko-Mazurskie voivodeship (North-Eastern Poland)
[So] Source:Przegl Epidemiol;71(4):547-554, 2017.
[Is] ISSN:0033-2100
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Trichomonas vaginalis is considered to be the most common non-viral sexually transmitted infection. Trichomoniasis is not a reportable disease and due to this fact only estimates can be made about its incidence AIM OF THE STUDY: The aim of the study was to determine the prevalence of T. vaginalis in the female population of north-eastern Poland as well as to conduct an epidemiological analysis on the basis of the data from the years of 2009 ­ 2015 derived from the registers of the National Health Fund MATERIALS AND METHODS: In this study 300 women aged 19 ­ 50 were examined. Two vaginal swabs were taken from each patient. The first swab was used to prepare microscope slides, and stained with Giemsa stain. The second swab was used for a diagnostic immunochromatographic rapid test (OSOM Trichomonasis test). Each woman was also asked to complete a questionnaire. Additionally, on the basis of the data from the National Health Fund, epidemiological analysis was conducted. Statistical analysis was performed with SPSS Statistics ver. 24 using Fisher test RESULTS: T. vaginalis infection was confirmed in two women. The diagnosis of trichomoniasis was confirmed as a result of T.vaginalis antigen detection with the use of immunochromatographic diagnostic test (OSOM Trichomonas test). The data from the National Health Fund show that 160 cases of trichomoniasis were reported, of which women accounted for 135 (84%), and men for 25 (16%). The highest infection rate was found in women aged 50 ­ 59 and those over 60 years old CONCLUSIONS: Our results show that the prevalence of T. vaginalis infection remains low, the infection occurs mainly in elderly women. However, one should pay attention to the differences in the detection of T. vaginalis connected with a particular method used. Conducting screen tests on a larger scale using more advanced tests would allow a more accurate assessment of the scale of the problem in our country
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180208
[Lr] Last revision date:180208
[St] Status:In-Data-Review

  10 / 4406 MEDLINE  
              first record previous record
select
to print
Photocopy
Full text

[PMID]: 29288183
[Au] Autor:Vallely LM; Toliman P; Ryan C; Rai G; Wapling J; Gabuzzi J; Allen J; Opa C; Munnull G; Kaima P; Kombuk B; Kumbia A; Kombati Z; Law G; Kelly-Hanku A; Wand H; Siba PM; Mola GDL; Kaldor JM; Vallely AJ
[Ad] Address:Public Health Interventions Research Group, Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.
[Ti] Title:Performance of syndromic management for the detection and treatment of genital , and among women attending antenatal, well woman and sexual health clinics in Papua New Guinea: a cross-sectional study.
[So] Source:BMJ Open;7(12):e018630, 2017 12 29.
[Is] ISSN:2044-6055
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Papua New Guinea (PNG) has among the highest estimated prevalences of genital (CT), (NG) and (TV) of any country in the Asia-Pacific region. Diagnosis and treatment of these infections have relied on the WHO-endorsed syndromic management strategy that uses clinical presentation without laboratory confirmation to make treatment decisions. We evaluated the performance of this strategy in clinical settings in PNG. DESIGN: Women attending antenatal (ANC), well woman (WWC) and sexual health (SHC) clinics in four provinces were invited to participate, completed a face-to-face interview and clinical examination, and provided genital specimens for laboratory testing. We estimated the performance characteristics of syndromic diagnoses against combined laboratory diagnoses. RESULTS: 1764 women were enrolled (ANC=765; WWC=614; SHC=385). The prevalences of CT, NG and TV were highest among women attending ANC and SHC. Among antenatal women, syndromic diagnosis of sexually transmitted infection had low sensitivity (9%-21%) and positive predictive value (PPV) (7%-37%), but high specificity (76%-89%) and moderate negative predictive value (NPV) (55%-86%) for the combined endpoint of laboratory-confirmed CT, NG or TV. Among women attending WWC and SHC, 'vaginal discharge syndrome' had moderate to high sensitivity (72%-78%) and NPV (62%-94%), but low specificity (26%-33%) and PPV (8%-38%). 'Lower abdominal pain syndrome' had low sensitivity (26%-41%) and PPV (8%-23%) but moderate specificity (66%-68%) and high NPV (74%-93%) among women attending WWC, and moderate-high sensitivity (67%-79%) and NPV (62%-86%) but low specificity (26%-28%) and PPV (14%-33%) among SHC attendees. CONCLUSION: The performance of syndromic management for the detection and treatment of genital chlamydia, gonorrhoea and trichomonas was poor among women in different clinical settings in PNG. New diagnostic strategies are needed to control these infections and to prevent their adverse health outcomes in PNG and other high-burden countries.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1712
[Cu] Class update date: 180206
[Lr] Last revision date:180206
[St] Status:In-Process
[do] DOI:10.1136/bmjopen-2017-018630


page 1 of 441 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information