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Almeida, Maria das Gracas
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[PMID]: 29437539
[Au] Autor:Senes-Lopes TF; López JA; do Amaral VS; Brandão-Neto J; de Rezende AA; da Luz JRD; Guterres ZDR; Almeida MDG
[Ad] Address:1 Program of Postgraduation in Health Sciences, Federal University of Rio Grande do Norte (UFRN) , Natal, Rio Grande do Norte, Brazil .
[Ti] Title:Genotoxicity of Turnera subulata and Spondias mombin × Spondias tuberosa Extracts from Brazilian Caatinga Biome.
[So] Source:J Med Food;, 2018 Feb 13.
[Is] ISSN:1557-7600
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Medicinal plants have been used in primary healthcare since the earliest days of humankind. Turnera subulata and Spondias mombin × Spondias tuberosa are widely used in the Brazilian Northeast to treat several diseases. The aim of this study was to evaluate the genotoxic effects of the leaf extracts of these species by the somatic mutation and recombination test in the somatic cells of Drosophila melanogaster wings. The experiments were performed using standard and high-bioactivation cross and three concentrations of the test substance [aqueous extract (AET and AES) at 5.0, 10.0, and 20.0 mg/mL and ethanolic extract (EET and EES) and ethyl acetate fraction (EAFT and EAFS) at 0.625, 1.25, and 2.5 mg/mL]. Results indicated that the extracts and fractions induced spontaneous frequencies of mutant spots in both D. melanogaster crosses. Nevertheless, the highest concentrations of the tested plant chemical agents were responsible for the statistically significant genotypic effect. T. subulata and S. mombin × S. tuberosa displayed genotoxic effect under the experimental conditions. The results from this study are crucial as they indicated the deleterious and side effects, considering the indiscriminate use of the extracts of these plants for disease treatment.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[St] Status:Publisher
[do] DOI:10.1089/jmf.2017.0041

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[PMID]: 29392442
[Au] Autor:Ochoa-López S; Rebollo R; Barton KE; Fornoni J; Boege K
[Ad] Address:Instituto de Ecología, Universidad Nacional Autónoma de México, Apartado Postal 70-275, Ciudad Universitaria, CP. 04510, Mexico City, Mexico.
[Ti] Title:Risk of herbivore attack and heritability of ontogenetic trajectories in plant defense.
[So] Source:Oecologia;, 2018 Feb 01.
[Is] ISSN:1432-1939
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Ontogeny has been identified as a main source of variation in the expression of plant phenotypes. However, there is limited information on the mechanisms behind the evolution of ontogenetic trajectories in plant defense. We explored if risk of attack, herbivore damage, heritability, and phenotypic plasticity can promote or constrain the evolutionary potential of ontogenetic trajectories in three defensive traits. We exposed 20 genotypes of Turnera velutina to contrasting environments (shadehouse and field plots), and measured the cyanogenic potential, trichome density, and sugar content in extrafloral nectar in seedlings, juveniles and reproductive plants. We also assessed risk of attack through oviposition preferences, and quantified herbivore damage in the field. We estimated genetic variance, broad sense heritability, and evolvability of the defensive traits at each ontogenetic stage, and of the ontogenetic trajectories themselves. For plants growing in the shadehouse, we found genetic variation and broad sense heritability for cyanogenic potential in seedlings, and for trichome density at all ontogenetic stages. Genetic variation and heritability of ontogenetic trajectories was detected for trichome density only. These genetic pre-requisites for evolution, however, were not detected in the field, suggesting that environmental variation and phenotypic plastic responses mask any heritable variation. Finally, ontogenetic trajectories were found to be plastic, differing between shadehouse and field conditions for the same genetic families. Overall, we provide support for the idea that changes in herbivore pressure can be a mechanism behind the evolution of ontogenetic trajectories. This evolutionary potential, however, can be constrained by phenotypic plasticity expressed in heterogeneous environments.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180202
[Lr] Last revision date:180202
[St] Status:Publisher
[do] DOI:10.1007/s00442-018-4077-7

  3 / 218 MEDLINE  
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[PMID]: 29099983
[Au] Autor:Kappel C; Huu CN; Lenhard M
[Ad] Address:Institute for Biochemistry and Biology, University of Potsdam, Karl-Liebknecht-Str. 24-25, House 26, D-14476 Potsdam-Golm, Germany.
[Ti] Title:A short story gets longer: recent insights into the molecular basis of heterostyly.
[So] Source:J Exp Bot;, 2017 11 01.
[Is] ISSN:1460-2431
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Heterostyly is a fascinating adaptation to promote outbreeding and a classical paradigm of botany. In the most common type of heterostyly, plants either form flowers with long styles and short stamens, or short styles and long stamens. This reciprocal organ positioning reduces pollen wastage and promotes cross-pollination, thus increasing male fitness. In addition, in many heterostylous species selfing and the generation of unfit progeny due to inbreeding depression is limited by a self-incompatibility system, thus promoting female fitness. The two floral forms are genetically determined by the S locus as a complex supergene, namely a chromosomal region containing several individual genes that control the different traits, such as style or stamen length, and are held together by very tight linkage due to suppressed recombination. Recent molecular-genetic studies in several systems, including Turnera, Fagopyrum, Linum, and Primula have begun to identify and characterize the causal heterostyly genes residing at the S locus. An emerging theme from several families is that the dominant S haplotype represents a hemizygous region not present on the recessive s haplotype. This provides an explanation for the suppressed recombination and suggests a scenario for the chromosomal evolution of the S locus. In this review, we discuss the results from recent molecular-genetic analyses in light of the classical models on the genetics and evolution of heterostyly.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171108
[Lr] Last revision date:171108
[St] Status:Publisher
[do] DOI:10.1093/jxb/erx387

  4 / 218 MEDLINE  
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[PMID]: 29073306
[Au] Autor:Rojek A; Kwasiuk K; Obara-Moszynska M; Kolesinska Z; Niedziela M
[Ad] Address:Department of Pediatric Endocrinology and Rheumatology, 2nd Chair of Pediatrics, Medical Faculty I, Poznan University of Medical Sciences, Poland.
[Ti] Title:Chromosom Y w zespole Turnera. [Y chromosome in Turner syndrome].
[So] Source:Pediatr Endocrinol Diabetes Metab;23(1):37-41, 2017.
[Is] ISSN:2083-8441
[Cp] Country of publication:Poland
[La] Language:pol
[Ab] Abstract:Turner syndrome (TS) is an inherited genetic disorder caused by numerical and/or structural chromosome X aberrations occurring at a frequency of 1:1200-1:2500 live-born girls. The most common karyotype is X chromosome monosomy (45,X) (approximately 50-60% of cases). Approximately 5-6% of patients may have abnormal Y chromosome or mosaicism characterized by the coexistence of 45,X cell line with cell line in which all or part of chromosome Y is present. In patients with TS who have all or fragmented genetic material from chromosome Y there is a substantial risk of cancerous lesions in these dysgenetic gonads. This paper stands for the review of the current knowledge on the genetic material of the Y chromosome in TS, especially in view of the risk of developing malignancies such as gonadoblastoma and dysgerminoma.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW
[Em] Entry month:1710
[Cu] Class update date: 171026
[Lr] Last revision date:171026
[St] Status:In-Process
[do] DOI:10.18544/PEDM-23.01.0072

  5 / 218 MEDLINE  
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[PMID]: 28948849
[Au] Autor:Edgar Romualdo EG; Lilia AM; Rafael SG; Alfredo SM
[Ad] Address:a Centro de Investigaciones Biológicas del Noroeste (CIBNOR) S.C. , La Paz , México.
[Ti] Title:Antioxidant effects of damiana (Turnera diffusa Willd. ex Schult.) in kidney mitochondria from streptozotocin-diabetic rats.
[So] Source:Nat Prod Res;:1-4, 2017 Sep 26.
[Is] ISSN:1478-6427
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The antioxidant effects of water-ethanol extract (WEE) from Turnera diffusa (damiana) in kidney mitochondria from experimental streptozotocin-induced diabetes mellitus (STZ-DM) rats was evaluated. STZ-DM rats were orally treated during three and five weeks. After experimental periods, kidney mitochondria were isolated and malondialdehyde (MDA), nitric oxide (NO•) and protein nitrosylation levels were measured. Also, blood glucose (BG) and body weight (BW) were recorded. Damiana significantly reduced the MDA and NO• levels in kidney mitochondria, although no changes in protein nitrosylation were observed and it did not have the potential to reverse the hyperglycaemia. In conclusion, WEE of T. diffusa have antioxidant properties that may prevent damage induced by mitochondrial oxidative stress in kidneys of STZ-DM rats.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170926
[Lr] Last revision date:170926
[St] Status:Publisher
[do] DOI:10.1080/14786419.2017.1380009

  6 / 218 MEDLINE  
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[PMID]: 28831641
[Au] Autor:Kovalsky IE; Roggero Luque JM; Elías G; Fernández SA; Solís Neffa VG
[Ad] Address:Instituto de Botánica del Nordeste (UNNE-CONICET), CC 209, 3400, Corrientes, Argentina.
[Ti] Title:The role of triploids in the origin and evolution of polyploids of Turnera sidoides complex (Passifloraceae, Turneroideae).
[So] Source:J Plant Res;, 2017 Aug 22.
[Is] ISSN:1618-0860
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:Triploids can play an important role in polyploid evolution. However, their frequent sterility is an obstacle for the origin and establishment of neotetraploids. Here we analyzed the microsporogenesis of triploids (x = 7) and the crossability among cytotypes of Turnera sidoides, aiming to test the impact of triploids on the origin and demographic establishment of tetraploids in natural populations. Triploids of T. sidoides exhibit irregular meiotic behavior. The high frequency of monovalents and of trivalents with non-convergent orientations results in unbalanced and/or non-viable male gametes. In spite of abnormalities in chromosome pairing and unbalanced chromosome segregation, triploids are not completely sterile and yielded up to 67% of viable pollen. Triploids that originated by the fusion of 2n × n gametes of the same taxon showed more regular meiotic behavior and higher fertility than triploids from the contact zone of diploids and tetraploids or triploids of hybrid origin. The reproductive isolation of T. sidoides cytotypes of different ploidy level is not strict and the 'triploid block' may be overcome occasionally. Triploids of T. sidoides produce diploid and triploid progeny suggesting that new generations of polyploids could originate from crosses between triploids or from backcrosses with diploids. The capability of T. sidoides to multiply asexually by rhizomes, would enhance the likelihood that a low frequency of neopolyploids can be originated and maintained in natural populations of T. sidoides.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170823
[Lr] Last revision date:170823
[St] Status:Publisher
[do] DOI:10.1007/s10265-017-0974-9

  7 / 218 MEDLINE  
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SciELO Brazil full text

[PMID]: 28640344
[Au] Autor:Porto KRA; Motti PR; Yano M; Roel AR; Cardoso CAL; Matias R
[Ad] Address:Universidade Católica Dom Bosco/UCDB, Av. Tamandaré, 6000, 79117-900 Campo Grande, MS, Brazil.
[Ti] Title:Screening of plant extracts and fractions on Aedes aegypti larvae found in the state of Mato Grosso do Sul (linnaeus, 1762) (culicidae).
[So] Source:An Acad Bras Cienc;89(2):895-906, 2017 Apr-Jun.
[Is] ISSN:1678-2690
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:The constant use of chemical insecticides for Aedes aegypti control has caused resistance in the mosquito populations. Thus, the objective of this study was to analyze the larvicidal potential of extracts and fractions of plants on A. aegypti larvae. The analysis included sixty one extracts and twenty five fractions of fifty botanical species at concentrations of 0.25; 0.12; 0.06 to 0.03 mg mL-1; 4 replications and one negative control of dechlorinate water and 1% DMSO; and a positive control with rotenone. The toxicity index in descending order with LC50 for the most active of the extracts selected were ethanol extract of Ormosea arborea (0.111 mg mL-1) seeds and ethanol extracts of leaves such as Piper hispidum (0.169 mg mL-1), Solanum variabile (0.188 mg mL-1), O. arborea (0.238 mg mL-1), Turnera umifolia (0.242 mg mL-1) and Piper hispidum (0.567 mg mL-1). For plant fractions, the most active were chloroform (0.192 mg mL-1) and hexane (0.342 mg mL-1) P. aduncum leaves, hexane fraction (0.415 mg mL-1) and methanol extract (0.625 mg mL-1) of Spermacocea latifolia leaves. Regarding the extract of T. umifolia single species, there is no bibliographic report on their degree of efficiency as an insecticide.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1706
[Cu] Class update date: 170622
[Lr] Last revision date:170622
[St] Status:In-Data-Review

  8 / 218 MEDLINE  
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[PMID]: 28606766
[Au] Autor:Bernardo J; Ferreres F; Gil-Izquierdo Á; Valentão P; Andrade PB
[Ad] Address:REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, no. 228, 4050-313 Porto, Portugal.
[Ti] Title:Medicinal species as MTDLs: Turnera diffusa Willd. Ex Schult inhibits CNS enzymes and delays glutamate excitotoxicity in SH-SY5Y cells via oxidative damage.
[So] Source:Food Chem Toxicol;106(Pt A):466-476, 2017 Aug.
[Is] ISSN:1873-6351
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:One of the most promising approaches to confront the complexity of central nervous system disorders are new multi-target directed ligands (MTDLs). Five medicinal species (Cereus grandiflorus (L.) Mill., Hyssopus officinalis L., Acorus calamus L., Silybum marianum L. Gaertn. and Turnera diffusa Willd. Ex Schult), selected for their ethnopharmacological relevance, were object for in vitro screening. The aqueous extract of T. diffusa revealed the strongest neuroactive potential, inhibiting monoamine oxidase-A (IC = 129.80 ± 11.97 µg/mL), and acetyl- and butyrylcholinesterase (IC = 0.352 ± 0.011 and 0.370 ± 0.036 mg/mL, respectively). Its phenolic profile was established for the first time by HPLC-DAD-ESI/MS . Twenty-six out of thirty-seven compounds were newly identified in this species. The pre-treatment with this flavonoid-rich extract promoted a rightward shift of the glutamate concentration neuronal cell (SH-SY5Y) death response curve. Furthermore, it significantly reduced the early phase formation of intracellular reactive species after glutamate and t-BHP exposure, suggesting that neuroprotection in SH-SY5Y cells was, in part, mediated by antioxidant mechanisms.
[Mh] MeSH terms primary: Central Nervous System Diseases/drug therapy
Glutamic Acid/metabolism
Oxidative Stress/drug effects
Plant Extracts/pharmacology
Plants, Medicinal/chemistry
Turnera/chemistry
[Mh] MeSH terms secundary: Antioxidants/chemistry
Antioxidants/pharmacology
Cell Line
Central Nervous System Diseases/metabolism
Glutamic Acid/toxicity
Humans
Mass Spectrometry
Phenols/chemistry
Phenols/pharmacology
Plant Extracts/chemistry
Reactive Oxygen Species/metabolism
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antioxidants); 0 (Phenols); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 3KX376GY7L (Glutamic Acid)
[Em] Entry month:1709
[Cu] Class update date: 170927
[Lr] Last revision date:170927
[Js] Journal subset:IM
[Da] Date of entry for processing:170614
[St] Status:MEDLINE

  9 / 218 MEDLINE  
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[PMID]: 28397755
[Au] Autor:Parra-Naranjo A; Delgado-Montemayor C; Fraga-López A; Castañeda-Corral G; Salazar-Aranda R; Acevedo-Fernández JJ; Waksman N
[Ad] Address:Departmento de Química Analítica, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, N.L., C.P. 64460, Mexico. ap._183@hotmail.com.
[Ti] Title:Acute Hypoglycemic and Antidiabetic Effect of Teuhetenone A Isolated from Turnera diffusa.
[So] Source:Molecules;22(4), 2017 Apr 08.
[Is] ISSN:1420-3049
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Diabetes mellitus is a chronic degenerative disease that causes long-term complications and represents a serious public health problem. (damiana) is a shrub that grows throughout Mexico and is traditionally used for many illnesses including diabetes. Although a large number of plant metabolites are known, there are no reports indicating which of these are responsible for this activity, and this identification was the objective of the present work. Through bioassay-guided fractionation of a methanolic extract obtained from the aerial part of , teuhetenone A was isolated and identified as the main metabolite responsible for the plant's hypoglycemic activity. Alpha-glucosidase inhibitory activity and cytotoxicity of this metabolite were determined. Hypoglycemic and antidiabetic activities were evaluated in a murine model of diabetes in vivo, by monitoring glucose levels for six hours and comparing them with levels after administering various controls. Teuhetenone A was not cytotoxic at the tested concentrations, and did not show inhibitory activity in the glucosidase test, and the in vivo assays showed a gradual reduction in glucose levels in normoglycemic and diabetic mice. Considering these results, we suggest that teuhetenone A has potential as an antidiabetic compound, which could be further submitted to preclinical assays.
[Mh] MeSH terms primary: Hypoglycemic Agents/chemistry
Hypoglycemic Agents/pharmacology
Plant Extracts/chemistry
Plant Extracts/pharmacology
Turnera/chemistry
[Mh] MeSH terms secundary: Animals
Blood Glucose/drug effects
Disease Models, Animal
Dose-Response Relationship, Drug
Glycoside Hydrolase Inhibitors/chemistry
Glycoside Hydrolase Inhibitors/pharmacology
Hypoglycemic Agents/isolation & purification
Inhibitory Concentration 50
Mice
Molecular Structure
Plant Extracts/isolation & purification
alpha-Glucosidases/metabolism
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Blood Glucose); 0 (Glycoside Hydrolase Inhibitors); 0 (Hypoglycemic Agents); 0 (Plant Extracts); EC 3.2.1.20 (alpha-Glucosidases)
[Em] Entry month:1705
[Cu] Class update date: 170531
[Lr] Last revision date:170531
[Js] Journal subset:IM
[Da] Date of entry for processing:170412
[St] Status:MEDLINE

  10 / 218 MEDLINE  
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Vilegas, Wagner
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[PMID]: 28288755
[Au] Autor:Oliveira AF; Costa Junior LM; Lima AS; Silva CR; Ribeiro MN; Mesquista JW; Rocha CQ; Tangerina MM; Vilegas W
[Ad] Address:Universidade Federal do Maranhão, Centro de Ciências Biológicas e da Saúde, CEP 65080-805 São Luís, MA, Brazil.
[Ti] Title:Anthelmintic activity of plant extracts from Brazilian savanna.
[So] Source:Vet Parasitol;236:121-127, 2017 Mar 15.
[Is] ISSN:1873-2550
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Helminth infections represent a serious problem for the production of small ruminants that is currently aggravated by resistance to anthelmintic products and has induced a search for control alternatives, such as natural products. In this study, extracts of Turnera ulmifolia L. (leaves and roots), Parkia platycephala Benth. (leaves and seeds) and Dimorphandra gardneriana Tul. (leaves and bark), which have been cited in ethnoveterinary studies and selected naturally by goats in the cerrado (Brazilian savanna), were tested in vitro against Haemonchus contortus. Hydroacetonic (ACT) and hydroalcoholic (ETH) extracts were evaluated using an Egg Hatching Assay (EHA), a Larval Exsheathment Inhibition Assay (LEIA) and a Larval Development Assay (LDA). A second set of incubations was performed using polyvinylpolypyrrolidone (PVPP) to determine the influence of polyphenols on the anthelmintic effects of EHA and LEIA. Data from each extract were used to calculate inhibition concentrations (IC ). All tested extracts showed activity against at least one life stage of H. contortus. The use of PVPP revealed that the tannins are not the only extracts of secondary metabolites responsible for the anthelmintic effects. The results showed clear in vitro anthelmintic activities against H. contortus at different stages and indicated the potential use of these species as a promising alternative approach to control helminthic infections of small ruminants.
[Mh] MeSH terms primary: Anthelmintics/pharmacology
Fabaceae/chemistry
Haemonchus/drug effects
Plant Extracts/pharmacology
Turnera/chemistry
[Mh] MeSH terms secundary: Animals
Brazil
Grassland
Plant Bark/chemistry
Plant Leaves/chemistry
Plant Roots/chemistry
Seeds/chemistry
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Anthelmintics); 0 (Plant Extracts)
[Em] Entry month:1709
[Cu] Class update date: 170908
[Lr] Last revision date:170908
[Js] Journal subset:IM
[Da] Date of entry for processing:170315
[St] Status:MEDLINE


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