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[PMID]: 29489658
[Au] Autor:Huang KH; Tai MC; Lee LC; Weng TH; Chen YH; Lin LF; Chen JT; Lu DW; Chen CL
[Ad] Address:Department of Ophthalmology, Tri-Service General Hospital.
[Ti] Title:Positron emission tomography/computed tomography scan of Vogt-Koyanagi-Harada syndrome with associated autoimmune thyroid disease: A case report and literature review.
[So] Source:Medicine (Baltimore);97(9):e0047, 2018 Mar.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Vogt-Koyanagi-Harada (VKH) syndrome is a rare disease and could be associated with autoimmune thyroid disease (AITD). This report was aimed to investigate the utility of F-fludeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) for the diagnosis of VKH syndrome with AITD and to perform a literature review on the association between the 2 diseases. PATIENT CONCERNS: A 55-year-old woman without the history of ocular trauma suffered from chronic headache. She was presented with painful blurred vision of both eyes with headache for 2 weeks. Ophthalmic evaluations revealed panuveitis, exudative retinal detachment, and papilloedema in both eyes. The clinical symptoms and presentations are compatible with the diagnosis of VKH syndrome. Other examinations for intraocular infection, malignancy, and lupus choroidopathy were of negative results. The result of contrast-enhanced computed tomography (CT) of the brain was normal. Due to the history of cancer in the patient's families, a F-FDG PET/CT whole-body scan was performed. The result indicated a focal of 2-fluoro-2-deoxy-D-glucose (FDG) uptake at the right upper lobe of the thyroid. Therefore, the patient's thyroid function was examined and the result indicated euthyroidism with detectable thyroid peroxidase/thyroglobulin antibodies. DIAGNOSES: VKH syndrome with associated AITD. INTERVENTIONS: Treatment with intravenous pulse systemic methylprednisolone (1000 mg daily) was prescribed for 3 days and then shifted gradually to tapered oral steroid medication. OUTCOMES: Symptoms of papillitis and serous retinal detachment of VKH syndrome was relieved after steroid treatment LESSONS:: F-fludeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) can be used for the effective diagnosis of VKH syndrome with AITD.
[Mh] MeSH terms primary: Positron Emission Tomography Computed Tomography
Thyroiditis, Autoimmune/complications
Thyroiditis, Autoimmune/diagnostic imaging
Uveomeningoencephalitic Syndrome/complications
Uveomeningoencephalitic Syndrome/diagnostic imaging
[Mh] MeSH terms secundary: Female
Fluorodeoxyglucose F18
Glucocorticoids/therapeutic use
Headache/etiology
Humans
Methylprednisolone/therapeutic use
Middle Aged
Thyroiditis, Autoimmune/drug therapy
Uveomeningoencephalitic Syndrome/drug therapy
Vision Disorders/etiology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Glucocorticoids); 0Z5B2CJX4D (Fluorodeoxyglucose F18); X4W7ZR7023 (Methylprednisolone)
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180301
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000010047

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[PMID]: 29334924
[Au] Autor:Zhao C; Dong F; Gao F; Liu X; Pei M; Jia S; Zhang M
[Ad] Address:Ophthalmology Department, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, 1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing, 100730, China.
[Ti] Title:Longitudinal observation of subretinal fibrosis in Vogt-Koyanagi-Harada disease.
[So] Source:BMC Ophthalmol;18(1):6, 2018 Jan 15.
[Is] ISSN:1471-2415
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Subretinal fibrosis (SRF) is a vision-threatening complication of Vogt-Koyanagi-Harada disease (VKH). It has long been recognized as a sequela of chronic inflammation. The developmental process of SRF, however, has not been described. The purpose of this study is to provide longitudinal observations of SRF in VKH. METHODS: Retrospective chart review of 10 VKH patients referred to our group between January 2008 and September 2015 at acute uveitic stage with SRF at presentation or who developed SRF during follow up. RESULTS: Ten patients (6 males and 4 females) with a median age of 39.0 (range, 23 to 58) years old were included. The median disease duration at presentation and median duration of follow up were 25.5 (range 5 to 60) days and 32.5 (range 13 to 61) months respectively. At presentation, all patients except one had been inappropriately treated with glucocorticosteroid (insufficiently dosed or tapered too fast) for longer than 2 weeks. Despite large dose oral glucocorticosteroid (1 mg/kg/d prednisone or equivalent) with slow tapering in combination with at least one immunomodulatory agent (cyclosporin A, cyclophosphamide or azathioprine) after presentation, all patients developed bilateral SRF within the first 4 months of disease course and 7 patients within the first 2 months. In 8 patients, shape-change/migration and progressive proliferation/pigmentation of SRF was observed over a period of several months after its formation, and then became quiescent but may further underwent depigmentation or pigmentation. SRF involved macula in 12 eyes (7 patients) and caused treatment resistant macular detachment and severe visual impairment in 6 eyes (4 patients). At the last visit, eyes with macular involvement were more common to had worse final best corrected visual acuity (≤20/50) than those without (9/12 vs. 0/8, p = 0.001). CONCLUSIONS: SRF usually develop early in the disease course in VKH patients who are not adequately controlled; it usually undergoes a highly dynamic process within the subretinal space and may involve the macula and resulted in poor final visual outcome.
[Mh] MeSH terms primary: Macula Lutea/pathology
Retinal Diseases/etiology
Uveomeningoencephalitic Syndrome/complications
Visual Acuity
[Mh] MeSH terms secundary: Adult
Female
Fibrosis/diagnosis
Fibrosis/etiology
Fluorescein Angiography
Follow-Up Studies
Fundus Oculi
Humans
Male
Middle Aged
Prognosis
Retinal Diseases/diagnosis
Retinal Diseases/physiopathology
Retrospective Studies
Time Factors
Tomography, Optical Coherence/methods
Uveomeningoencephalitic Syndrome/diagnosis
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:IM
[Da] Date of entry for processing:180117
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0670-0

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[PMID]: 29443768
[Au] Autor:Liu B; Deng T; Zhu L; Zhong J
[Ad] Address:Department of Ophthalmology, the First Affiliated Hospital of Jinan University.
[Ti] Title:Association of human leukocyte antigen (HLA)-DQ and HLA-DQA1/DQB1 alleles with Vogt-Koyanagi-Harada disease: A systematic review and meta-analysis.
[So] Source:Medicine (Baltimore);97(7):e9914, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: The aim of this study was to evaluate the association of human leukocyte antigen (HLA)-DQ and HLA-DQA1/DQB1 alleles with Vogt-Koyanagi-Harada (VKH), providing further evidences on the genetic background of this disease. METHODS: A comprehensive literature search was conducted on the relationship of HLA-DQ and/or HLA-DQA1/DQB1 alleles with VKH through PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, VIP, and databases for grey literature. The last search was in October 2017. Pooled odds ratio (OR) with 95% confidence interval (95% CI) was calculated from extracted data to access the strength of the association between a genotype and VKH. RESULTS: HLA-DQ4 was confirmed to increase the risk of VKH significantly (OR = 4.63, 95% CI: 1.74-12.31, P = .002), while HLA-DQ1 seemed to reduce VKH occurrence with OR = 0.32 (95% CI: 0.22-0.47, P < .00001). HLA-DQA1*0301-(OR = 4.52, 95% CI: 1.42-14.35, P = .01) and HLA-DQB1*0401-(OR = 23.12, 95% CI: 11.54-46.31, P < .00001) positive patients probably had a rising tendency to suffer from VKH. Alleles including HLA-DQA1*0103, 0401, 0501 and HLA-DQB1*0301, 0402, 0601, 0603 were significant protective genetic factors. CONCLUSION: We concluded that HLA-DQ4 carriers had a higher risk of VKH and HLA-DQ1 seemed to be protective. People with positive HLA-DQA1*0301 and HLA-DQB1*0401 demonstrated to be more susceptible to VKH. HLA-DQA1*0103, 0401, 0501 and HLA-DQB1*0301, 0402, 0601, 0603 could be potential protectors.
[Mh] MeSH terms primary: HLA-DQ Antigens/genetics
HLA-DQ alpha-Chains/genetics
HLA-DQ beta-Chains/genetics
Uveomeningoencephalitic Syndrome/genetics
[Mh] MeSH terms secundary: Genetic Predisposition to Disease
Humans
Protective Factors
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (HLA-DQ Antigens); 0 (HLA-DQ alpha-Chains); 0 (HLA-DQ beta-Chains); 0 (HLA-DQ4 antigen); 0 (HLA-DQA1 antigen); 0 (HLA-DQB1 antigen)
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180215
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009914

  4 / 1005 MEDLINE  
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[PMID]: 29264653
[Au] Autor:Nakamura T; Hayashi A; Oiwake T
[Ad] Address:Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan. nakatomo@med.u-toyama.ac.jp.
[Ti] Title:Recovery of macular cone photoreceptors in Vogt-Koyanagi-Harada disease.
[So] Source:Graefes Arch Clin Exp Ophthalmol;256(2):387-394, 2018 Feb.
[Is] ISSN:1435-702X
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:PURPOSE: Our purpose was to study changes in macular cone photoreceptors in Vogt-Koyanagi-Harada (VKH) disease patients after high-dose corticosteroid treatment using an adaptive optics (AO) fundus camera. METHODS: We retrospectively analyzed 16 eyes of eight patients with new-onset acute VKH disease that were studied retrospectively. After serous retinal detachment (SRD) had resolved, AO images were obtained using the rtx1™ AO fundus camera over a 12-month course. Cone counting was performed in the nasal, temporal, superior and inferior areas of the macula 0.75 mm from the foveal center. A control group of 30 eyes of 30 healthy subjects was established for comparison. RESULTS: In the eyes with VKH disease, the mean cone densities 0.75 mm from the foveal center were 11,847 at baseline (resolution of SRD), and 15,218, 16,684 and 17,686 cones/mm , at 3, 6, and 12 months later, respectively. The mean cone densities at 3, 6, and 12 months were significantly increased compared to those of baseline (p = 0.007, p < 0.001, and p < 0.001, respectively); however, they were significantly lower than that of the healthy control eyes (p < 0.001). The mean cone densities at areas with a previous presence of cystoid spaces were significantly lower than those without cystoid spaces at the baseline, and at 3, 6, and 12 months (p < 0.001, p = 0.007, p < 0.001, and p = 0.008, respectively). CONCLUSIONS: Cone densities were gradually increased after the resolution of SRD in the eyes of VKH disease patients. The presence of cystoid spaces might be a marker of severe damage to cone photoreceptors.
[Mh] MeSH terms primary: Macula Lutea/physiopathology
Recovery of Function
Retinal Cone Photoreceptor Cells/physiology
Uveomeningoencephalitic Syndrome/physiopathology
[Mh] MeSH terms secundary: Adult
Cell Count
Choroid/pathology
Female
Fluorescein Angiography
Follow-Up Studies
Fovea Centralis/pathology
Fundus Oculi
Glucocorticoids/therapeutic use
Humans
Macula Lutea/pathology
Male
Middle Aged
Prognosis
Retinal Cone Photoreceptor Cells/cytology
Retrospective Studies
Time Factors
Tomography, Optical Coherence
Uveomeningoencephalitic Syndrome/diagnosis
Uveomeningoencephalitic Syndrome/drug therapy
Visual Acuity
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Glucocorticoids)
[Em] Entry month:1802
[Cu] Class update date: 180214
[Lr] Last revision date:180214
[Js] Journal subset:IM
[Da] Date of entry for processing:171222
[St] Status:MEDLINE
[do] DOI:10.1007/s00417-017-3869-5

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[PMID]: 29050185
[Au] Autor:Jia SS; Zhao C; Gong D; Chen Z; Zhang MF
[Ad] Address:Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
[Ti] Title:[Optical coherence tomography angiography of acute Vogt-Koyanagi-Harada disease].
[So] Source:Zhonghua Yan Ke Za Zhi;53(10):735-739, 2017 Oct 11.
[Is] ISSN:0412-4081
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:To measure vascular density in retinal and choroidal capillary layers by optical coherence tomography angiography (OCTA) and to explore their potential clinical values in Vogt-Koyanagi-Harada disease (VKH). This is a cross-sectional case-control study. Twenty-one acute VKH cases presented to Peking Union Medical College Hospital between April 2015 and July 2015 and 49 healthy controls were enrolled in this study. OCTA was performed with a split-spectrum amplitude-decorrelation angiography-optical coherence tomography (SSADA-OCT) system borrowed from Optovue Inc. Vascular densities of the capillary layers were analyzed by the built-in software. Bilateral independent sample -test was used to compare retinal and choroidal vascular density of eyes in acute phase VKH with healthy controls. Spearman correlation test was used to analyze the correlation between the vascular density of retina and choroid in acute phase VKH and LogMAR best corrected visual acuity (BCVA). Mean vascular density of superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris (CC) in eyes of the acute VKH group were statistically lower than those of healthy control group (51.56%±2.88%, 56.51%±2.31%, 58.14%±2.10% . 53.55%±2.51%, 58.14%±2.10%, 58.14%±2.10%, 3.890, 3.910,-6.554, all 3 values were<0.01). In VKH patients, eyes with retinal detachment (RD) had statistically lower mean vascular density in the CC layer than those without (NRD) (63.46%±2.19% . 65.85%±1.79%, 3.890, 0.01), while no statistically significant differences were found in vascular densities of SCP and DCP layers between RD and NRD eyes. Spearman's correlation test revealed a negative correlation between vascular density of the CC layer and logMAR BCVA( =-0.437, 0.01), while no statistically significant associations were found between logMAR BCVA and vascular densities of SCP and DCP. OCTA can be used for quantitative detection of vascular density of retina and choroidal capillary in acute VKH. There is circulatory disturbance in SCP, DCP and CC of acute VKH. Vascular density of CC is associated with visual acuity and retinal detachment. .
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171019
[Lr] Last revision date:171019
[St] Status:In-Data-Review
[do] DOI:10.3760/cma.j.issn.0412-4081.2017.10.004

  6 / 1005 MEDLINE  
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[PMID]: 28979622
[Au] Autor:Amraoui ME; Zemmez Y; Bouhamidi A; Frikh R; Hjira N; Boui M
[Ad] Address:Service de Dermatologie-Vénéréologie, Hôpital Militaire d'Instruction Mohammed V, Rabat, Maroc.
[Ti] Title:Vitiligo révélant une maladie de Vogt-Koyanagi-Harada. [Vitiligo revealing Vogt -Koyanagi-Harada disease].
[So] Source:Pan Afr Med J;27:220, 2017.
[Is] ISSN:1937-8688
[Cp] Country of publication:Uganda
[La] Language:fre
[Ab] Abstract:Vitiligo is a chronic auto-immune skin disease, often associated or discovers other autoimmune pathologies. His association with Ophthalmological type pan uveitis and/or neurological type of meningitis and/or inner ear type of hearing loss determines the disease or Vogt -Koyanagi-Harada syndrome (VKH). We related the case of a young woman who consulted for recurrent uveitis for a year, and it was only with the onset of vitiligo lesions that VKH disease diagnosis was discussed and confirmed.
[Mh] MeSH terms primary: Uveitis/diagnosis
Uveomeningoencephalitic Syndrome/diagnosis
Vitiligo/etiology
[Mh] MeSH terms secundary: Adult
Female
Humans
Recurrence
Uveitis/etiology
Uveomeningoencephalitic Syndrome/pathology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171023
[Lr] Last revision date:171023
[Js] Journal subset:IM
[Da] Date of entry for processing:171006
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.220.11656

  7 / 1005 MEDLINE  
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[PMID]: 28972425
[Au] Autor:Pryse-Phillips W
[Ad] Address:William Pryse-Phillips, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.
[Ti] Title:Lord Nelson's (1758-1805) left eye.
[So] Source:J Med Biogr;:967772015624391, 2017 Jan 01.
[Is] ISSN:1758-1087
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Following the loss of his right eye at Calvi in 1794, Lord Nelson suffered increasing left-sided visual loss, here considered most likely to have been due to the ocular inflammatory condition 'sympathetic ophthalmia'. It is also argued that his succeeding episodes of violent headaches with nausea and prostration, and possible depigmentation of hair, reflected the development of an uveomeningoencephalitic syndrome akin to that of Vogt-Koyanagi-Harada disease, which is best regarded as the same condition with a different aetiology.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171003
[Lr] Last revision date:171003
[St] Status:Publisher
[do] DOI:10.1177/0967772015624391

  8 / 1005 MEDLINE  
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[PMID]: 28863408
[Au] Autor:Miura M; Makita S; Yasuno Y; Tsukahara R; Usui Y; Rao NA; Ikuno Y; Uematsu S; Agawa T; Iwasaki T; Goto H
[Ad] Address:Department of Ophthalmology, Tokyo Medical University, Ibaraki Medical Center, Ami, Japan.
[Ti] Title:Polarization-Sensitive Optical Coherence Tomographic Documentation of Choroidal Melanin Loss in Chronic Vogt-Koyanagi-Harada Disease.
[So] Source:Invest Ophthalmol Vis Sci;58(11):4467-4476, 2017 Sep 01.
[Is] ISSN:1552-5783
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Purpose: Vogt-Koyanagi-Harada (VKH) disease is a systemic autoimmune disorder that affects organs with melanocytes. The sunset glow fundus (SGF) in VKH disease was evaluated with polarization-sensitive optical coherence tomography (PS-OCT). Methods: The study involved 28 eyes from 14 patients with chronic VKH disease, 21 eyes from 21 age-matched controls, and 22 eyes from 22 high-myopic patients with a tessellated fundus. VKH eyes were grouped into sunset or non-sunset groups on the basis of color fundus images. The presence of melanin in the choroid was determined by using the degree of polarization uniformity (DOPU) obtained by PS-OCT. The sunset glow index (SGI) was calculated by using color fundus images. Presence of an SGF was evaluated by using DOPU, SGI, subfoveal choroidal thicknesses, near-infrared images, and autofluorescence images at 488 nm (SW-AF) and 785 nm (NIR-AF). Results: There were 16 eyes in the sunset group and 12 eyes in the non-sunset group. For all eyes in the sunset group, the disappearance of choroidal melanin was clearly detected with PS-OCT. Percentage areas of low DOPU in the choroidal interstitial stroma of the sunset group were significantly lower than those of other groups and showed no overlap with other groups. The distribution of choroidal thicknesses and SGI in the sunset group substantially overlapped with other groups. The subjective analyses of the sunset and non-sunset groups, using near infrared, SW-AF, or NIR-AF, showed substantial inconsistencies with the PS-OCT results. Conclusions: PS-OCT provides an in vivo objective evaluation of choroidal melanin loss of the SGF in chronic VKH disease.
[Mh] MeSH terms primary: Choroid Diseases/metabolism
Diagnostic Techniques, Ophthalmological
Melanins/metabolism
Uveomeningoencephalitic Syndrome/metabolism
[Mh] MeSH terms secundary: Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers/metabolism
Chronic Disease
Cross-Sectional Studies
Female
Humans
Imaging, Three-Dimensional
Male
Melanocytes/metabolism
Microscopy, Polarization
Middle Aged
Multimodal Imaging
Tomography, Optical Coherence
Uveomeningoencephalitic Syndrome/diagnosis
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Biomarkers); 0 (Melanins)
[Em] Entry month:1709
[Cu] Class update date: 170908
[Lr] Last revision date:170908
[Js] Journal subset:IM
[Da] Date of entry for processing:170902
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22117

  9 / 1005 MEDLINE  
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[PMID]: 28846771
[Au] Autor:Deng J; Hu J; Tan H; Su G; Cao Q; Huang X; Kijlstra A; Yang P
[Ad] Address:The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, People's Republic of China.
[Ti] Title:Association of a PDCD1 Polymorphism With Sympathetic Ophthalmia in Han Chinese.
[So] Source:Invest Ophthalmol Vis Sci;58(10):4218-4222, 2017 Aug 01.
[Is] ISSN:1552-5783
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Purpose: Several studies have shown that sympathetic ophthalmia (SO) and Vogt-Koyanagi-Harada (VKH) disease possess many similarities concerning their clinical manifestations. The aim of this study was to investigate whether single nucleotide polymorphisms that have been shown to be associated with VKH disease in earlier studies may also be associated with SO. Methods: There were 114 SO patients and 1230 healthy controls included in a case-control study, whereby 24 VKH-related single nucleotide polymorphisms (SNPs) were tested. Genotyping was performed using the MassARRAY platform and iPLEX Gold Assay. Results: The results showed a significantly lower frequency of the PDCD1/rs2227981 GG genotype in SO (Pc =7.85 × 10-3, OR = 0.471). However, no apparent increase in the GA and AA genotype frequency was detected. Moreover, a significant decrease in the G allele frequency of PDCD1/rs2227981 was detected in SO (Pc = 5.08 × 10-3, OR = 0.56). Conclusions: This study shows that only PDCD1/rs2227981 contributes to the genetic susceptibility of SO, and that the other 23 susceptibility loci of VKH disease are probably not involved in the pathogenesis of this disease.
[Mh] MeSH terms primary: Asian Continental Ancestry Group/genetics
Ophthalmia, Sympathetic/genetics
Polymorphism, Single Nucleotide
Programmed Cell Death 1 Receptor/genetics
[Mh] MeSH terms secundary: Adolescent
Adult
Aged
Case-Control Studies
Child
China/epidemiology
Female
Gene Frequency
Genetic Predisposition to Disease
Genotyping Techniques
Humans
Male
Middle Aged
Uveomeningoencephalitic Syndrome/genetics
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (PDCD1 protein, human); 0 (Programmed Cell Death 1 Receptor)
[Em] Entry month:1709
[Cu] Class update date: 170904
[Lr] Last revision date:170904
[Js] Journal subset:IM
[Da] Date of entry for processing:170829
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22195

  10 / 1005 MEDLINE  
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[PMID]: 28606265
[Au] Autor:Li B; Ye JJ; Zhang MF; Li DH
[Ad] Address:Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences Beijing 100730, China.
[Ti] Title:[The fundus manifestations and SD-OCT findings of patients with acute Vogt-Koyanagi-Harada disease].
[So] Source:Zhonghua Yan Ke Za Zhi;53(6):436-439, 2017 Jun 11.
[Is] ISSN:0412-4081
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:To conclude the characteristics of fundus appearance and spectral domain optical coherence tomography(SD-OCT) findings of patients with acute Vogt-Koyanagi-Harada (VKH) disease. The clinical data of 17 patients (34 eyes) diagnosed of acute VKH in Peking Union Medical College Hospital from Jan. 2012 to Dec. 2014 were studied retrospectively.Examinations included visual acuity, slit lamp, fundus, color fundus pictures, FFA and SD-OCT. Eight men and 9 women were enrolled with mean age of (40.5±11.6) years old ranging from 26.0 to 62.0 years old. Vision acuity of their first consultations were as follows: 14 eyes (41.2%) were below 0.01-0.09, 17 eyes(50%) were among 0.1-0.3, 3 eyes (8.8%) were among 0.4-0.7. All patients were divided into 3 groups according to their fundus appearance: 14 eyes (41.2%) were optic disc swelling-type, 10 eyes (29.4%) were retinal detachment type and 10 eyes(29.4%)were mixed type. Subretinal fluid and serous retinal detachment appears in SD-OCT of all 34 eyes, with highly reflective signals in detached area. Other common characters were also noticeable, suh as RPE folds(19 eyes, 55.9%), subretinal septa (16 eyes, 47.1%) and internal limiting membrane(ILM) fluctuation (8 eyes, 23.5%). In addition, SD-OCT features were in accordance with multilobular dye pooling at late period of FFA. SD-OCT of acute VKH presents some typical features: subretinal fluid and serous retinal detachment, RPE folds, ILM fluctuation, and subretinal septa. .
[Mh] MeSH terms primary: Fundus Oculi
Tomography, Optical Coherence
Uveomeningoencephalitic Syndrome/diagnostic imaging
[Mh] MeSH terms secundary: Acute Disease
Adult
Female
Fluorescein Angiography
Humans
Male
Middle Aged
Papilledema/diagnostic imaging
Retina/diagnostic imaging
Retinal Detachment/diagnostic imaging
Retrospective Studies
Slit Lamp Microscopy
Visual Acuity
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170906
[Lr] Last revision date:170906
[Js] Journal subset:IM
[Da] Date of entry for processing:170614
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0412-4081.2017.06.008


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BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information