Database : MEDLINE
Search on : Vascular and Neoplasms [Words]
References found : 83093 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 8310 go to page                         

  1 / 83093 MEDLINE  
              next record last record
select
to print
Photocopy
Full text

[PMID]: 29339432
[Au] Autor:Lee HR; Li F; Choi UY; Yu HR; Aldrovandi GM; Feng P; Gao SJ; Hong YK; Jung JU
[Ad] Address:Department of Biotechnology and Bioinformatics, College of Science and Technology, Korea University, Sejong, South Korea leehr@korea.ac.kr jaeujung@med.usc.edu.
[Ti] Title:Deregulation of HDAC5 by Viral Interferon Regulatory Factor 3 Plays an Essential Role in Kaposi's Sarcoma-Associated Herpesvirus-Induced Lymphangiogenesis.
[So] Source:MBio;9(1), 2018 Jan 16.
[Is] ISSN:2150-7511
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent for Kaposi's sarcoma (KS), which is one of the most common HIV-associated neoplasms. The endothelium is the thin layer of squamous cells where vascular blood endothelial cells (BECs) line the interior surface of blood vessels and lymphatic endothelial cells (LECs) are in direct contact with lymphatic vessels. The KS lesions contain a prominent compartment of neoplastic spindle morphology cells that are closely related to LECs. Furthermore, while KSHV can infect both LECs and BECs , its infection activates genetic programming related to lymphatic endothelial cell fate, suggesting that lymphangiogenic pathways are involved in KSHV infection and malignancy. Here, we report for the first time that viral interferon regulatory factor 3 (vIRF3) is readily detected in over 40% of KS lesions and that vIRF3 functions as a proangiogenic factor, inducing hypersprouting formation and abnormal growth in a LEC-specific manner. Mass spectrometry analysis revealed that vIRF3 interacted with histone deacetylase 5 (HDAC5), which is a signal-responsive regulator for vascular homeostasis. This interaction blocked the phosphorylation-dependent cytosolic translocation of HDAC5 and ultimately altered global gene expression in LECs but not in BECs. Consequently, vIRF3 robustly induced spindle morphology and hypersprouting formation of LECs but not BECs. Finally, KSHV infection led to the hypersprouting formation of LECs, whereas infection with a ΔvIRF3 mutant did not do so. Collectively, our data indicate that vIRF3 alters global gene expression and induces a hypersprouting formation in an HDAC5-binding-dependent and LEC-specific manner, ultimately contributing to KSHV-associated pathogenesis. Several lines of evidences indicate that KSHV infection of LECs induces pathological lymphangiogenesis and that the results resemble KS-like spindle morphology. However, the underlying molecular mechanism remains unclear. Here, we demonstrated that KSHV vIRF3 is readily detected in over 40% of various KS lesions and functions as a potent prolymphangiogenic factor by blocking the phosphorylation-dependent cytosolic translocation of HDAC5, which in turn modulates global gene expression in LECs. Consequently, vIRF3-HDAC5 interaction contributes to virus-induced lymphangiogenesis. The results of this study suggest that KSHV vIRF3 plays a crucial role in KSHV-induced malignancy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Data-Review

  2 / 83093 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29505538
[Au] Autor:Zhu J; Li H; Ding L; Cheng H
[Ad] Address:Department of Radiology.
[Ti] Title:Imaging appearance of renal epithelioid angiomyolipoma: A case report and literature review.
[So] Source:Medicine (Baltimore);97(1):e9563, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Epithelioid angiomyolipoma (EAML) is an extremely rare disease. It commonly occurs in middle-aged females and mainly involves the kidney. Histological and immunohistochemical examination play important roles in differentiating EAML from renal cell carcinoma (RCC) and poor-fat angiomyolipoma (AML). PATIENT CONCERNS: Here, We report the imaging phenotype, as well as the pathological findings of a case of EAML in a 39-year-old female. DIAGNOSES: Preoperative noncontrast computed tomography (CT) scan revealed a 6.0 × 5.2 × 7.0 cm soft tissue mass with necrosis, located in the left kidney. On contrast-enhanced CT images, aprogressive enhancement pattern was observed. CT angiography did not show any enlarged vessels or vascular malformation. Abdominal MRI showed a well-circumscribed solid mass with a heterogeneous signal on T1-weighted and T2-weighted images. Ultrasonography of the abdomen demonstrated a hypoechoic mass with abundant blood flow. This patient underwent radical nephrectomy. The pathologic diagnosis was EAML. INTERVENTIONS: This patient underwent operative resection of the tumor. The resection margins were negative for the neoplastic proliferation and no distant metastases were found. The patient did not receive advanced radiotherapy or chemotherapy. OUTCOMES: Four months after surgery, the follow-up CT scan did not reveal any local recurrence or distant metastases. LESSONS: This case adds to the experience with EAML by summarizing its imaging characteristics as well as reviewing the literature. Additionally, we described the state-of-the-art management of the management of this rare tumor.
[Mh] MeSH terms primary: Angiomyolipoma/diagnostic imaging
Kidney Neoplasms/diagnostic imaging
[Mh] MeSH terms secundary: Adult
Angiomyolipoma/pathology
Female
Humans
Kidney/pathology
Kidney Neoplasms/pathology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180306
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009563

  3 / 83093 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29411910
[Au] Autor:Palicelli A; Neri P; Marchioro G; De Angelis P; Bondonno G; Ramponi A
[Ad] Address:Department of Health Science, School of Medicine, University of Eastern Piedmont 'Amedeo Avogadro', Novara, Italy.
[Ti] Title:Paratesticular seminoma: echographic features and histological diagnosis with review of the literature.
[So] Source:APMIS;126(3):267-272, 2018 Mar.
[Is] ISSN:1600-0463
[Cp] Country of publication:Denmark
[La] Language:eng
[Ab] Abstract:Primary extratesticular seminomas exceptionally occur in the epididymis or in the paratesticular region/spermatic cord. Some old papers included poor histological description or insufficient photographic documentation, reducing the number of faithful cases: an up-to-date systematic review is lacking. We report the 4th primary seminoma of the paratesticular region/spermatic cord in a 35-year-old man, including the first echographic description. We provide review of the literature and etiopathogenetic discussion. Ultrasound examination showed a right paratesticular, solid, heterogeneous mass (iso-hypoechoic with hyperechoic striae; peri- and intra-lesional vascular signals) with no testicular involvement: the paratesticular origin was confirmed by pathological examination. Despite careful gross examination and extensive sampling, the 6.5-cm extratesticular tumor revealed only one microscopic focus with minimal invasion (<2 mm) of the atrophic testicular parenchyma. Intratubular germ cell neoplasia or morphologic features of a regressed testicular tumor (fibrosis/scar, necrosis, hyalinization, calcification, inflammation) were not found. Primary seminomas of the paratesticular region/spermatic cord occurred at an older mean age and presented as bigger lesions if compared to the 9 primary epididymal seminomas reported in literature. Clinical-pathological correlation and accurate sampling are mandatory for a correct diagnosis.
[Mh] MeSH terms primary: Epididymis/pathology
Seminoma/pathology
Spermatic Cord/pathology
Testicular Neoplasms/pathology
[Mh] MeSH terms secundary: Adult
Epididymis/diagnostic imaging
Humans
Male
Seminoma/diagnostic imaging
Spermatic Cord/diagnostic imaging
Testicular Neoplasms/diagnostic imaging
Ultrasonography
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:180208
[St] Status:MEDLINE
[do] DOI:10.1111/apm.12806

  4 / 83093 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy

[PMID]: 29376611
[Au] Autor:Epifanova MV; Chalyi ME; Gvasaliya BR; Eremin II; Pulin AA; Nadelyaeva II; Artemenko SA; Galitskaya DA; Repin AM
[Ad] Address:Research Institute for Uronephrology and Human Reproductive Health, Moscow, Russia.
[Ti] Title:[New approaches for recovery of erectile function in patients after radical prostatectomy].
[So] Source:Urologiia;(6):138-143, 2017 Dec.
[Is] ISSN:1728-2985
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:Prostate cancer (PCa) is one of the most common maligmancies and causes of death among men. Radical prostatectomy (RP) is optimal and recommended treatment modality for localized prostate cancer. More than half of all men undergoing surgery experience problems with erectile function and existing treatments do not provide a positive effect. Thus, there is a need for new approaches to the restoration of erectile function in patients after RP. One of these is the use of cell technologies, namely the stromal-vascular fraction and autologous platelet-rich plasma. This review examines the results of preclinical and clinical studies investigating the efficacy and safety of these treatment options in erectile dysfunction.
[Mh] MeSH terms primary: Erectile Dysfunction
Penile Erection
Postoperative Complications/therapy
Prostatectomy/adverse effects
Prostatic Neoplasms/surgery
Recovery of Function
[Mh] MeSH terms secundary: Erectile Dysfunction/etiology
Erectile Dysfunction/therapy
Humans
Male
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:180130
[St] Status:MEDLINE

  5 / 83093 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy

[PMID]: 29376613
[Au] Autor:Akhvlediani ND; Shvarts PG; Kirichuk YV
[Ad] Address:I.M. Sechenov First MSMU of Minzdrav of Russia, Moscow, Russia.
[Ti] Title:[Erectile dysfunction after nerve-sparing radical prostatectomy].
[So] Source:Urologiia;(6):149-152, 2017 Dec.
[Is] ISSN:1728-2985
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:Nerve-sparing radical prostatectomy remains the optimal curative treatment of prostate cancer in patients who want to maintain erectile function. Since its development, there has been a gradual decline in its effectiveness concerning the prevention of ED, which was associated with the currently more objective assessment of erectile function at both the pre- and post-operative stage. There is a knowledge gap in the precise understanding of which specific neural structures should be preserved with the nerve-sparing technique. At the same time, there have been proposed effective methods for visualizing the elements of the preserved vascular-neural bundle and estimating the degree of nerve-sparing.
[Mh] MeSH terms primary: Erectile Dysfunction
Postoperative Complications/prevention & control
Prostatectomy
Prostatic Neoplasms/surgery
[Mh] MeSH terms secundary: Erectile Dysfunction/etiology
Erectile Dysfunction/prevention & control
Humans
Male
Prostatectomy/adverse effects
Prostatectomy/methods
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:180130
[St] Status:MEDLINE

  6 / 83093 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29331379
[Au] Autor:Shinagawa-Kobayashi Y; Kamimura K; Goto R; Ogawa K; Inoue R; Yokoo T; Sakai N; Nagoya T; Sakamaki A; Abe S; Sugitani S; Yanagi M; Fujisawa K; Nozawa Y; Koyama N; Nishina H; Furutani-Seiki M; Sakaida I; Terai S
[Ad] Address:Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Niigata, Japan.
[Ti] Title:Effect of histidine on sorafenib-induced vascular damage: Analysis using novel medaka fish model.
[So] Source:Biochem Biophys Res Commun;496(2):556-561, 2018 02 05.
[Is] ISSN:1090-2104
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Sorafenib (SFN) is an anti-angiogenic chemotherapeutic that prolongs survival of patients with hepatocellular carcinoma (HCC); its side effects, including vascular damages such as hand-foot syndrome (HFS), are a major cause of therapy discontinuation. We previously reported that maintenance of peripheral blood flow by intake of dried bonito broth (DBB) significantly prevented HFS and prolonged the administration period. The amino acids contained in DBB probably contribute to its effects, but the mechanism has not been clarified. We hypothesized that histidine, the largest component among the amino acids contained in DBB, has effects on SFN-induced vascular damage, and evaluated this possibility using a novel medaka fish model. METHODS: The fli::GFP transgenic medaka fish model has a fluorescently visible systemic vasculature. We fed the fish with SFN with and without histidine to compare blood flow and vascular structure among the differently fed models. The vascular cross-sectional area of each fish was measured to determine vascular diameter changes. RESULTS: Our results demonstrated that SFN-fed medaka developed a narrower vascular diameter. In addition, this narrowing was counteracted by addition of histidine to the medaka diet. We observed no positive effect of histidine on regeneration of cut vessels or on cell growth of endothelial cells and HCC cell lines. CONCLUSION: We proved the efficacy of the medaka model to assess vascular changes after administration of specific chemicals. And our results suggest that SFN causes vascular damage by narrowing peripheral vessel diameter, and that histidine effectively counteracts these changes to maintain blood flow.
[Mh] MeSH terms primary: Antineoplastic Agents/adverse effects
Blood Flow Velocity/drug effects
Blood Vessels/drug effects
Blood Vessels/pathology
Histidine/pharmacology
Niacinamide/analogs & derivatives
Phenylurea Compounds/adverse effects
[Mh] MeSH terms secundary: Animals
Carcinoma, Hepatocellular/drug therapy
Humans
Liver Neoplasms/drug therapy
Niacinamide/adverse effects
Oryzias
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Antineoplastic Agents); 0 (Phenylurea Compounds); 25X51I8RD4 (Niacinamide); 4QD397987E (Histidine); 9ZOQ3TZI87 (sorafenib)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:180115
[St] Status:MEDLINE

  7 / 83093 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29520447
[Au] Autor:Florou V; Wilky BA
[Ad] Address:University of Miami Sylvester Comprehensive Cancer Center, 1475 NW 12th Avenue, Suite 3300 (D8-4), Miami, FL, 33136, USA.
[Ti] Title:Current and Future Directions for Angiosarcoma Therapy.
[So] Source:Curr Treat Options Oncol;19(3):14, 2018 Mar 08.
[Is] ISSN:1534-6277
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OPINION STATEMENT: Angiosarcomas are rare vascular neoplasms that are among the most aggressive subtypes of soft tissue sarcomas. Surgical resection is often challenging even in localized disease, as the infiltrative nature of these cancers leads to frequent local and metastatic recurrences. Cytotoxic chemotherapy, including anthracycline-based regimens and taxanes can produce significant responses in a subset of patients but durability is limited with most patients ultimately succumbing to metastatic disease. Targeted therapy with tyrosine kinase inhibitors is usually well-tolerated but prone to development of resistance. Few head-to-head trials have addressed the optimal sequence of therapies, or demonstrated conclusive benefits of one therapy over another based on clinical and etiologic factors. Novel therapies in clinical trials, including antibodies to endoglin and checkpoint inhibitors have demonstrated exciting early activity in patients with angiosarcoma. Improved understanding of the genetic heterogeneity within various angiosarcoma subtypes may identify predictive biomarkers to match patients to effective existing and future therapies. Overall, angiosarcoma patients with optimal performance status are best served in clinical trials that incorporate novel combinations of cytotoxic chemotherapy, targeted therapies, and immunotherapies.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review
[do] DOI:10.1007/s11864-018-0531-3

  8 / 83093 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29507614
[Au] Autor:Gauberti M; Fournier AP; Docagne F; Vivien D; Martinez de Lizarrondo S
[Ad] Address:Normandie Univ, UNICAEN, INSERM, INSERM UMR-S U1237, Physiopathology and Imaging for Neurological Disorders (PhIND), Cyceron, 14000 Caen, France.
[Ti] Title:Molecular Magnetic Resonance Imaging of Endothelial Activation in the Central Nervous System.
[So] Source:Theranostics;8(5):1195-1212, 2018.
[Is] ISSN:1838-7640
[Cp] Country of publication:Australia
[La] Language:eng
[Ab] Abstract:Endothelial cells of the central nervous system over-express surface proteins during neurological disorders, either as a cause, or a consequence, of the disease. Since the cerebral vasculature is easily accessible by large contrast-carrying particles, it constitutes a target of choice for molecular magnetic resonance imaging (MRI). In this review, we highlight the most recent advances in molecular MRI of brain endothelial activation and focus on the development of micro-sized particles of iron oxide (MPIO) targeting adhesion molecules including intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), P-Selectin and E-Selectin. We also discuss the perspectives and challenges for the clinical application of this technology in neurovascular disorders (ischemic stroke, intracranial hemorrhage, subarachnoid hemorrhage, diabetes mellitus), neuroinflammatory disorders (multiple sclerosis, brain infectious diseases, sepsis), neurodegenerative disorders (Alzheimer's disease, vascular dementia, aging) and brain cancers (primitive neoplasms, metastasis).
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review
[do] DOI:10.7150/thno.22662

  9 / 83093 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy

[PMID]: 29400034
[Au] Autor:Kharoubi S
[Ti] Title:[Benign tumors of the nasal cavity, new classification and review of the literature. Report of 54 cases].
[So] Source:Rev Laryngol Otol Rhinol (Bord);136(4):131-42, 2015.
[Is] ISSN:0035-1334
[Cp] Country of publication:France
[La] Language:fre
[Ab] Abstract:Benign tumors of the nasal cavity is an uncommon disease and very diverse about histological variety. Theses tumors are seen at any age without specificity in semiological aspect. The diagnostic approach is based on nasal endoscopy, imaging (CT-MRI) and biopsy. In some anatomo clinical varieties the result of biopsy is so difficult and we must analyze all the tumor specimen after surgery with modern biological procedure (immunohistochemistry, molecular biology). The treatment is surgery especially with endonasal endoscopic procedure. Our series included 54 benign endonasal tumors between January 1998 and December 2008. The mean age of our population is 28 years with a female sex ratio of 1.16. Endoscopic examina­tion and a CT scan of facial bones were systematic. The tumors of nasal septum were predominant. The histological variety are dominated by vascular tumors (hemangioma) in 36 cases (66.6%) and papilloma (papilloma and inverted papilloma) in 15 cases (27.7%), two cases of fibroma (37%) and one case of leiomyoma. The treatment was surgical with an endonasal approach in 37 cases (68.5%), endonasal and endoscopic in 11 cases (20.3%) and external 6 cases (11.1%). A review of the literature on tumors of the nasal cavity is made during this study.
[Mh] MeSH terms primary: Nasal Cavity/pathology
Nose Neoplasms/pathology
[Mh] MeSH terms secundary: Adolescent
Adult
Aged
Aged, 80 and over
Child
Endoscopy
Female
Fibroma/pathology
Fibroma/surgery
Hemangioma/pathology
Hemangioma/surgery
Humans
Leiomyoma/pathology
Leiomyoma/surgery
Male
Middle Aged
Nasal Cavity/surgery
Nose Neoplasms/surgery
Papilloma/pathology
Papilloma/surgery
Retrospective Studies
Young Adult
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:180206
[St] Status:MEDLINE

  10 / 83093 MEDLINE  
              first record previous record
select
to print
Photocopy

[PMID]: 29400026
[Au] Autor:El Bakkouri W; Blanc R; Benzakin S; Abdellaoui A; Boyeldieu L; Ayache D
[Ti] Title:[Innovations in interventional radiology applied to the field of otolaryngology: A pictorial essay].
[So] Source:Rev Laryngol Otol Rhinol (Bord);136(3):91-5, 2015.
[Is] ISSN:0035-1334
[Cp] Country of publication:France
[La] Language:fre
[Ab] Abstract:The management of hypervascular ENT tumors is usually complex and requires a multidisciplinary approach because of the risk of serious intra-operative bleeding and of potential injuries to cranial nerves and/or large cervical vessels. Over the last four decades, advances in neuro-interventional radio­logical procedures have produced a range of adjunctive endo­vascular techniques in addition to conventional surgery. A pictorial essay in ENT specialty is presented in this article highlighting the most relevant innovations in interventional radiology.
[Mh] MeSH terms primary: Otolaryngology
Radiology, Interventional
[Mh] MeSH terms secundary: Hemorrhage/therapy
Humans
Ophthalmic Artery
Retinal Neoplasms/drug therapy
Retinoblastoma/drug therapy
Tinnitus/therapy
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:180206
[St] Status:MEDLINE


page 1 of 8310 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information