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[PMID]: 24882804
[Au] Autor:Son MH; Jung MY; Choi S; Cho D; Kim TS
[Ad] Address:Department of Life Sciences, Korea University, Seoul 136-701, Republic of Korea....
[Ti] Title:IL-32γ induces chemotaxis of activated T cells via dendritic cell-derived CCL5.
[So] Source:Biochem Biophys Res Commun;450(1):30-5, 2014 Jul 18.
[Is] ISSN:1090-2104
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Interleukin (IL)-32 has been associated with a variety of inflammatory diseases including rheumatoid arthritis, vasculitis and Crohn's disease. We have previously reported that IL-32γ, the IL-32 isoform with the highest biological activity, could act as an immune modulator through regulation of dendritic cell (DC) functions in immune responses. Cell locomotion is crucial for induction of an effective immune response. In this study, we investigated the effect and underlying mechanisms of IL-32γ on recruitment of T cells. IL-32γ upregulated the expression of several chemokines including CCL2, CCL4, and CCL5 in the DCs. In particular, IL-32γ significantly increased CCL5 expression in a dose-dependent manner. Treatment with JNK and NF-κB inhibitors suppressed IL-32γ-induced CCL5 expression in DCs, indicating that IL-32γ induced CCL5 production through the JNK and NF-κB pathways. Furthermore, supernatants from IL-32γ-treated DCs showed chemotactic activities controlling migration of activated CD4(+) and CD8(+) T cells, and these activities were suppressed by addition of neutralizing anti-CCL5 antibody. These results show that IL-32γ effectively promotes migration of activated T cells via CCL5 production in DCs. The chemotactic potential of IL-32γ may explain the pro-inflammatory effects of IL-32 and the pathologic role of IL-32 in immune disorders such as rheumatoid arthritis.
[Mh] MeSH terms primary: Cell Communication/immunology
Chemokine CCL5/immunology
Chemotaxis/immunology
Dendritic Cells/immunology
Interleukins/pharmacology
Lymphocyte Activation/immunology
[Mh] MeSH terms secundary: Animals
Cell Communication/drug effects
Cells, Cultured
Chemotaxis/drug effects
Dendritic Cells/drug effects
Female
Lymphocyte Activation/drug effects
Mice
Mice, Inbred C57BL
T-Lymphocytes
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Ccl5 protein, mouse); 0 (Chemokine CCL5); 0 (Interleukins); 0 (interleukin-32, mouse)
[Em] Entry month:1409
[Js] Journal subset:IM
[Da] Date of entry for processing:140721
[St] Status:MEDLINE

  2 / 32242 MEDLINE  
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[PMID]: 23870089
[Au] Autor:Maggioli E; Boiocchi C; Zorzetto M; Mannarino S; Bossi G; Cuccia M
[Ad] Address:Laboratory of Immunogenetics, Department of Biology & Biotechnology "L.Spallanzani", University of Pavia, Pavia, Italy.
[Ti] Title:HLA class III genes involvement in Kawasaki disease: a case-control study in Caucasian population.
[So] Source:Int J Immunogenet;41(1):44-53, 2014 Feb.
[Is] ISSN:1744-313X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Kawasaki disease (KD) is an acute, multisystemic, febrile vasculitis of unknown aetiology, which affects young children mainly under 5years of age. The clinical variability has until now prevented to decrypt KD aetiological factors. Recently, the importance of genetics and the pivotal role of the immune system have emerged. To investigate in this direction, genomic DNA from 74 Caucasian KD cases and 440 healthy controls has been analysed to characterize functional polymorphisms of relevant HLA class III genes: AGER -429 and -374, TNF -857, -308 and -238, HSPA1A +190, HSPA1B +1267 and HSPA1L +2437. Allele, genotype and haplotype frequencies were therefore compared with the chi-squared test and Fisher's exact test. Our data showed significant deviations between patients with Kawasaki disease and controls concerning the TNF -308 polymorphism genotype (GG: P=0.0449) and allele (G,A: P=0.0433) and -238 polymorphism genotype frequencies (AA: P=0.0351). Moreover, we found differences concerning the HSPA1A +190 polymorphism (GC: P=0.0317) and the HSPA1L +2437 polymorphism (TT: P=0.0072; TC: P=0.0250; T: P=0.0037; C: P=0.0037). The calculation of TNF -238 and HSPA1L haplotype frequencies also pointed out a statistically significant decrease in patients of CG haplotype (P=0.0001), which could have a role in protecting from the inflammatory processes that characterize the disease progression. The results obtained point to a possible involvement of the entire HLA class III region in KD susceptibility.
[Mh] MeSH terms primary: Genetic Predisposition to Disease
HSP70 Heat-Shock Proteins/genetics
Mucocutaneous Lymph Node Syndrome/genetics
Receptors, Immunologic/genetics
Tumor Necrosis Factor-alpha/genetics
[Mh] MeSH terms secundary: Alleles
Case-Control Studies
Child, Preschool
European Continental Ancestry Group/genetics
Female
Gene Frequency
Genotype
Haplotypes
Humans
Infant
Linkage Disequilibrium
Male
Mucocutaneous Lymph Node Syndrome/immunology
Polymorphism, Single Nucleotide
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (HSP70 Heat-Shock Proteins); 0 (Receptors, Immunologic); 0 (Tumor Necrosis Factor-alpha); 0 (advanced glycosylation end-product receptor)
[Em] Entry month:1409
[Js] Journal subset:IM
[Da] Date of entry for processing:140110
[St] Status:MEDLINE
[do] DOI:10.1111/iji.12077

  3 / 32242 MEDLINE  
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[PMID]: 25232290
[Au] Autor:Salah S; Rizk S; Lotfy HM; El Houchi S; Marzouk H; Farag Y
[Ad] Address:Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt....
[Ti] Title:MEFV gene mutations in Egyptian children with Henoch-Schonlein purpura.
[So] Source:Pediatr Rheumatol Online J;12:41, 2014.
[Is] ISSN:1546-0096
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Due to an increased frequency of vasculitis in FMF patients, many investigators have studied MEFV mutations in patients with HSP. The aim of the study is to investigate the frequency and clinical significance of MEFV mutations in Egyptian children with Henoch-Schonlein purpura (HSP). Investigating MEFV mutations in controls may help in estimating the prevalence of MEFV mutation carrier rate in Egyptian children. METHODS: The study enrolled 90 individuals, sixty children with Henoch-Schonlein purpura (HSP), together with 30 sex-and age-matched apparently healthy controls. The entire study group was screened for 12 common MEFV mutations using a reverse hybridization assay of biotinylated PCR products. RESULTS: Patients with HSP had a significantly higher frequency of MEFV mutations (61.7%), when compared to the apparently healthy control population (36.7%). V726A was the most frequent mutation with an allelic frequency of 10.8%. Ninety- one percent of patients with MEFV mutations were heterozygous for one mutation, while 8.1% had a compound heterozygous MEFV gene mutations. The mutation V726A, followed by E148Q, were the leading mutations, present in 16.6% and in 13.3% of controls. CONCLUSIONS: MEFV mutations may be related to HSP susceptibility in children. The mutations were not associated with any clinical and laboratory manifestations. Screening for MEFV mutations in larger number of HSP children may be beneficial to evaluate any possible relationship between certain types of MEFV mutations and HSP, and compare the HSP MEFV mutations to the types of MEFV mutations associated with FMF.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1186/1546-0096-12-41

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[PMID]: 25232440
[Au] Autor:Aravena V; Beltrn V; Cantn M; Fuentes R
[Ad] Address:Department of Adult Dentistry, Faculty of Medicine and Dentistry, Universidad de Antofagasta Antofagasta, Chile....
[Ti] Title:Gingival hyperplasia being the first sign of Wegener's granulomatosis.
[So] Source:Int J Clin Exp Med;7(8):2373-6, 2014.
[Is] ISSN:1940-5901
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Wegener's granulomatosis (GW) is a multisystemic granulomatous vasculitis that predominantly affects the airways and the kidneys, but may affect any organ. Otorhinolaryngological manifestations may be gingival swelling, oral ulcer or septal perforations that can cause saddle nose deformities, rhinitis, sinusitis and hearing loss. We report a case of WG that was first diagnosed on oral gingival mucosa. A 54-year old woman was referred to a specialized dentist because of consistent irritative buccal gingival hyperplasia that did not react to conservative and microbial treatment. The lesion was biopsied and the diagnosis was suggestive for WG. Patient was further referred to the Unit of Rheumatology and the diagnose of WG was confirmed and treated. This case emphasizes the importance to recognize the oral manifestation of WG to get proper medication as soon as possible and avoid serious systemic tissue damage.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Cu] Class update date: 140920
[Lr] Last revision date:140920
[Da] Date of entry for processing:140918
[St] Status:PubMed-not-MEDLINE

  5 / 32242 MEDLINE  
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[PMID]: 25232332
[Au] Autor:Kinoshita T; Fukushima K; Abe RT; Ogawa Y; Nakagawa M; Katoh N; Yoshida T; Kato H; Ikeda S
[Ad] Address:Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan....
[Ti] Title:Motor branch biopsy of the pronator teres muscle in a patient with painful forearm neuropathy.
[So] Source:Case Rep Neurol;6(2):202-6, 2014 May.
[Is] ISSN:1662-680X
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Histological evaluation of a peripheral nerve is often the final diagnostic work-up for a neuropathy of unknown origin, and a distal sensory nerve is usually biopsied. Here, we report the case of a female patient with painful unilateral neuropathy in the upper arm. According to the histological evaluation of the pronator teres motor branch, vasculitis seemed to be the most probable cause of the condition, and steroid therapy improved the patients' symptoms. A biopsy of the motor branch of the pronator teres muscle nerve may be considered a valuable diagnostic option in selected cases with neuropathy affecting the upper limb, when performed in cooperation with neurologists and orthopedic surgeons.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Cu] Class update date: 140920
[Lr] Last revision date:140920
[Da] Date of entry for processing:140918
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1159/000365883

  6 / 32242 MEDLINE  
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[PMID]: 25106665
[Au] Autor:Pasquet F; Pavic M; Ninet J; Hot A
[Ad] Address:Service de mdecine interne-oncologie, hpital d'instruction des armes Desgenettes, 108, boulevardd Pinel, 69003 Lyon, France. Electronic address: florianpasquet@wanadoo.fr....
[Ti] Title:Maladies auto-immunes et cancers. Deuxime partie: maladies auto-immunes au cours des cancers et de leur traitement. [Auto-immune diseases and cancers. Second part: Auto-immune diseases complicating cancers and their treatment].
[So] Source:Rev Med Interne;35(10):656-63, 2014 Oct.
[Is] ISSN:1768-3122
[Cp] Country of publication:France
[La] Language:fre
[Ab] Abstract:Autoimmune diseases may reveal or occur during the course of a neoplasia or its treatment. Autoimmune cytopenia, especially haemolytic anaemia, is common in lymphoproliferative disorders such as chronic lymphoid leukemia. The link between cancer and myositis is well established. Dermatomyositis is associated with an increased relative risk of cancer of 3.4 to 4.4. A combination of detection of antibodies against p155 and TEP-computed tomography may be the best approach to ascertain the presence of occult malignancy in patients with dermatomyositis. A cutaneous or a systemic vascularitis may reveal a cancer, most often a haematological malignancy such as hairy cell leukemia. Paraneoplastic polyarthritis have been described in particular with adenocardinoma of the lungs. Underlying neoplasia should be considered in male smokers patients with new onset polyarthritis and poor health status. The prevalence of autoimmune conditions in myelodysplastic syndromes is 10 to 30%. Vasculitis and relapsing polychondritis are the most commonly reported manifestations. Immune manifestations can also be related to treatment. The most common treatment complications are autoimmune haemolytic anaemia with fludarabine and thyroiditis related to interferon and cervical radiotherapy.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review

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[PMID]: 24359727
[Au] Autor:Debouverie O; Roy-Paud F; Braud G; Blanchard-Delaunay C; Roblot F; Pourrat O; Roblot P
[Ad] Address:Service de mdecine interne et maladies infectieuses, universit de Poitiers, CHU de Poitiers, 2, rue de la Miltrie, BP 577, 86021 Poitiers, France. Electronic address: odiledebouverie@gmail.com....
[Ti] Title:vnements infectieux au cours des vascularites ncrosantes systmiques: tude rtrospective de 82cas. [Infectious events during the course of systemic necrotizing vasculitis: A retrospective study of 82cases].
[So] Source:Rev Med Interne;35(10):636-42, 2014 Oct.
[Is] ISSN:1768-3122
[Cp] Country of publication:France
[La] Language:fre
[Ab] Abstract:PURPOSE: The aim of this study was to assess the infections occurring in a series of 82patients followed for a systemic necrotizing vasculitis and to determine potential risk factors. METHODS: We studied retrospectively the medical files of 23Churg and Strauss syndrome, 18periarteritis nodosa, 14microscopic polyangiitis, and 27granulomatosis with polyangiitis, over a 15-year period. Infection delay corresponded to the period from treatment to first infection or between two infections. RESULTS: A total of 61patients developed 147infections. Causal agent was identified in 70cases, 42were bacterial, 20viral and 8fungal. Bronchopneumonia was the most frequent infection (43%). Sixty-two percent of infections occurred within 2years after vasculitis diagnosis. Seven infections were major, requiring intensive care, with one infection-death related. Pneumocystis prophylaxis concerned 75% of patients on cyclophosphamide. Significant factors reducing infection delay were initial hypergammaglobulinemia, hypoalbuminemia, lymphopenia, as well as cyclophosphamide and methotrexate treatment. Large quantities of corticosteroids, cyclophosphamide or azathioprine increased infection delay. This result underlines the early occurrence of infectious complications during vasculitis course. CONCLUSION: Infectious events occurring in systemic necrotizing vasculitis are frequent and occurs early in disease course, and could be prevented with simple prophylactic measures. Vasculitis relapse and infection share similarities and this require permanent clinical vigilance.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review

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[PMID]: 24290029
[Au] Autor:Lemaignen A; Goulenok T; Kalamarides S; Plat A; Pfau G; Fantin B
[Ad] Address:Service de mdecine interne, hpital Beaujon, universit Paris Diderot, Sorbonne Paris-Cit, AP-HP, 100, boulevard du Gnral-Leclerc, 92110 Clichy, France....
[Ti] Title:Agranulocytose et vascularite chez un patient cocanomane: lvamisole ou l'autre poison cach [Agranulocytosis and vasculitis in a cocaine addict: Levamisole, the hidden culprit].
[So] Source:Rev Med Interne;35(10):676-9, 2014 Oct.
[Is] ISSN:1768-3122
[Cp] Country of publication:France
[La] Language:fre
[Ab] Abstract:INTRODUCTION: Adulterants are compounds added to street drugs to increase profits for the seller. Levamisole, a veterinary antihelminthic agent, has become the most common adulterant of cocaine. The prevalence of levamisole in samples of cocaine is increasing. Levamisole can lead to neutropenia and to a dramatic vasculopathy and even vasculitis of small and medium-size blood vessels. CASE REPORT: We here reported the first French case of levamisole related toxicity, due to cocaine use in a 50-year-old man, revealed by fever and agranulocytosis, high titters of antineutrophil cytoplasmic antibodies (ANCA), anticoagulant and positive Coombs tests. Outcome was slowly favorable with exposition withdrawal. CONCLUSION: Clinicians should be aware that agranulocytosis or vasculitis or vasculopathy could be related to levamisole toxicity in individuals who use cocaine.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review

  9 / 32242 MEDLINE  
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[PMID]: 25239588
[Au] Autor:Malavieille F; Page M; Ber CE; Christin F; Bonnet A; Rimmele T
[Ad] Address:Dpartement d'anesthsie et de ranimation, hpital douard-Herriot, hospices civils de Lyon, 5, place d'Arsonval, 69437 Lyon cedex 03, France. Electronic address: francois.malavieille@chu-lyon.fr....
[Ti] Title:Le syndrome pneumo-rnal aigu: un mode de rvlation rare de la granulomatose avec polyangite. [The acute pulmonary renal syndrome: An unusual presentation of granulomatosis with polyangiitis].
[So] Source:Rev Mal Respir;31(7):636-40, 2014 Sep.
[Is] ISSN:1776-2588
[Cp] Country of publication:France
[La] Language:fre
[Ab] Abstract:INTRODUCTION: We report a case of acute pulmonary renal syndrome mimicking septic shock, which led to the diagnosis of granulomatosis with polyangiitis. CASE REPORT: A 70-year-old man was hospitalized because of acute kidney injury and acute respiratory distress syndrome with diffuse alveolar hemorrhage associated with a serum procalcitonin level of 18g/L. Initially, septic shock was suspected and antibiotic therapy was started. The absence of microbiological isolates and the patient's rapid clinical deterioration prompted laboratory testing for autoimmune disease, which confirmed the diagnosis of granulomatosis with polyangiitis. Immunosuppressive therapy was promptly initiated with corticosteroids, cyclophosphamide and several plasma exchanges, which resulted in a rapid clinical improvement and ICU discharge. CONCLUSIONS: Granulomatosis with polyangiitis is a systemic necrotizing vasculitis with antineutrophil cytoplasmic antibodies, which can present with acute pulmonary renal syndrome, combining acute respiratory distress syndrome and acute kidney injury. This misleading presentation must prompt an autoimmune disease testing in order to yield an early diagnosis of a vasculitis, allowing for timely initiation of immunosuppressive treatment. Serum procalcitonin levels can be markedly elevated and this must not override the possibility of a vasculitis where the patient shows a compatible symptomatology.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review

  10 / 32242 MEDLINE  
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[PMID]: 25232837
[Au] Autor:Weerakoon K; Kularatne SA; Rajapakse J; Adikari S; Waduge R
[Ad] Address:Department of Parasitology, Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, Sri Lanka....
[Ti] Title:Cutaneous manifestations of spotted Fever rickettsial infections in the central province of sri lanka: a descriptive study.
[So] Source:PLoS Negl Trop Dis;8(9):e3179, 2014 Sep.
[Is] ISSN:1935-2735
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Characteristic skin lesions play a key role in clinical diagnosis of spotted fever group rickettsioses and this study describes these cutaneous manifestations along with basic histological features. METHODS AND FINDINGS: Study was conducted at Medical Unit, Teaching Hospital, Peradeniya, from November 2009 to October 2011, where a prospective data base of all rickettsial infections is maintained. Confirmation of diagnosis was made when IgM and IgG immunofluorescent antibody titre of 1/32 and >1/256 respectively. Of the 210 clinical cases, 134 had cutoff antibody titers for Rickettsia conorii antigen for confirmation. All these 134 patients had fever and skin rash, and of them 132(98%) had discrete maculopapular rash while eight (6%) had fern leaf type skin necrosis. Eight patients (6%) had healed tick bite marks. Average size of a skin lesion was 5 mm and rash involved 52% of body surface, distributed mainly in limbs and back of the chest. Generally the facial and leg skin was slightly oedematous particularly in old aged patients. Sixteen patients (12%) had pain and swelling of ankle joints where swelling extended to feet and leg. Biopsies from skin rash of six patients showed evidence of cutaneous vasculitis and of them, 247 bp region of the 17-kDa spotted fever group specific protein antigen was amplified using PCR. CONCLUSIONS: A discrete maculopapular rash and occasional variations such as fern leaf shape necrosis and arthritis are found in spotted fever group. Histology found vasculitis as the pathology of these lesions.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1371/journal.pntd.0003179


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