Database : MEDLINE
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[PMID]: 25152825
[Au] Autor:Singh N; Saurabh S; Tan IJ
[Ad] Address:Immunology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, C42 E 10, Iowa City, IA 52241, USA.
[Ti] Title:Takayasu's Arteritis and Crohn's Disease in a Young Hispanic Female.
[So] Source:Case Rep Rheumatol;2014:246852, 2014.
[Is] ISSN:2090-6889
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Takayasu's arteritis (TA) and Crohn's disease (CD) are chronic inflammatory granulomatous disorders of undetermined etiology. TA is a large vessel vasculitis with a predilection for the aorta and its branches in young women of Asian descent; whereas CD has characteristic gastrointestinal manifestations more prevalent in young Caucasians. We describe a case of both diseases in a young Hispanic female, review the literature, and impart new insight on possible genetic linkage and the role of interleukin 12 B (IL-12B) as the common autoimmune mechanism and potential therapeutic target in this rare disease combination.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Da] Date of entry for processing:140825
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1155/2014/246852

  2 / 32139 MEDLINE  
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[PMID]: 24659312
[Au] Autor:Nagata H; Yamamura K; Uike K; Nakashima Y; Hirata Y; Morihana E; Mizuno Y; Ishikawa S; Hara T
[Ad] Address:Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka City 812-8582, Japan. dadan@pediatr.med.kyushu-u.ac.jp
[Ti] Title:Evaluation of echogenicity of the heart in Kawasaki disease.
[So] Source:Eur J Pediatr;173(8):1089-93, 2014 Aug.
[Is] ISSN:1432-1076
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Pathologic studies of the heart in patients with Kawasaki disease (KD) revealed vasculitis, valvulitis, myocarditis, and pericarditis. However, there have been no studies on the quantitative determination of multi-site echogenicity of the heart in KD patients. It is also undetermined whether the degree of echogenicity of each site of the heart in patients with KD might be related to the response to intravenous immunoglobulin (IVIG) treatment. In 81 KD patients and 30 control subjects, we prospectively analyzed echogenicity of the heart. Echogenicity was measured in four sites: coronary artery wall (CAW), mitral valve (MV), papillary muscle (PM), and ascending aortic wall (AAo wall) by the calibrated integrated backscatters (cIBs). The cIB values of all measurement sites at acute phase in KD patients were significantly higher than those in control subjects (KD patients vs control subjects; CAW, 19.8 ± 6.2 dB vs 14.5 ± 2.0 dB, p < 0.05; MV, 23.3 ± 5.3 dB vs 16.0 ± 3.3 dB, p < 0.05; PM, 22.4 ± 5.1 dB vs 12.7 ± 1.9 dB, p < 0.05; AAo wall, 25.3 ± 5.6 dB vs 18.3 ± 3.4 dB, p < 0.05). The cIB values of CAW at the acute phase in IVIG nonresponders were significantly higher than those in responders. Conclusion: Echogenicity of the heart in KD patients at the acute phase increased not only in the coronary artery wall but also in other parts of the heart. Echogenicity of CAW might be helpful in determining the unresponsiveness of IVIG treatment.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1007/s00431-014-2296-4

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[PMID]: 25148534
[Au] Autor:Kuo HC; Huang YH; Chien SC; Yu HR; Hsieh KS; Hsu YW; Chang WC
[Ad] Address:Department of Pediatrics and Kawasaki Disease Center, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan....
[Ti] Title:Genetic Variants of CD209 Associated with Kawasaki Disease Susceptibility.
[So] Source:PLoS One;9(8):e105236, 2014.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Kawasaki disease (KD) is a systemic vasculitis with unknown etiology mainly affecting children in Asian countries. Dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN, CD209) in humans was showed to trigger an anti-inflammatory cascade and associated with KD susceptibility. This study was conducted to investigate the association between genetic polymorphisms of CD209 and the risk KD. METHODS: A total of 948 subjects (381 KD and 567 controls) were recruited. Nine tagging SNPs (rs8112310, rs4804800, rs11465421, rs1544766, rs4804801, rs2287886, rs735239, rs735240, rs4804804) were selected for TaqMan allelic discrimination assay. Clinical phenotypes, coronary artery lesions (CAL) and intravenous immunoglobulin (IVIG) treatment outcomes were collected for analysis. RESULTS: Significant associations were found between CD209 polymorphisms (rs4804800, rs2287886, rs735240) and the risk of KD. Haplotype analysis for CD209 polymorphisms showed that A/A/G haplotype (P = 0.0002, OR = 1.61) and G/A/G haplotype (P = 0.0365, OR = 1.52) had higher risk of KD as compared with G/G/A haplotype in rs2287886/rs735239/rs735240 pairwise allele analysis. There were no significant association in KD with regards to CAL formation and IVIG treatment responses. CONCLUSION: CD209 polymorphisms were responsible for the susceptibility of KD, but not CAL formation and IVIG treatment responsiveness.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1371/journal.pone.0105236

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[PMID]: 25150234
[Au] Autor:Ortiz-Diaz EO
[Ad] Address:Department of Pulmonary and Critical Care, Baptist Health, Miami, Florida, USA.
[Ti] Title:A 27-year-old woman presenting with refractory hypoxaemic respiratory failure, haemoptysis and thyrotoxicosis: a rare manifestation of propylthiouracil therapy.
[So] Source:BMJ Case Rep;2014, 2014.
[Is] ISSN:1757-790X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Pulmonary manifestations of hyperthyroidism not only include pulmonary hypertension and hydrostatic pulmonary oedema, but also treatment/drug-associated pulmonary diseases have to be considered as an exclusion diagnosis. A 27-year-old woman with hypoxaemic respiratory failure under an arterial-venous extra-corporeal membrane oxygenator (AV-ECMO) was admitted to the intensive care unit (ICU). The patient had progressive dyspnoea with haemoptysis, palpitations and failure to thrive. The patient had Graves' disease treated previously with propylthiouracil (PTU). Diffuse alveolar haemorrhage is a non-specific syndrome characterised by evidence of diffuse alveolar damage, exclusion of infectious aetiology and progressively bloodier bronchoalveolar lavage (and/or 20% hemosiderin laden macrophages on cytological examination). PTU associated perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) vasculitis appears to be more common in younger female patients presenting with leukocytoclastic vasculitis, myalgias and arthralgias. The latter compared to non-drug associated ANCA vasculitis which are more common in older males with visceral involvement. PTU-induced ANCA vasculitis prognosis appears to be better compared to primary ANCA syndromes.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review

  5 / 32139 MEDLINE  
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[PMID]: 25051945
[Au] Autor:Varma N; Hinojar R; D'Cruz D; Arroyo Ucar E; Indermuehle A; Peel S; Greil G; Gaddum N; Chowienczyk P; Nagel E; Botnar RM; Puntmann VO
[Ad] Address:Cardiovascular Imaging Department, Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom....
[Ti] Title:Coronary Vessel Wall Contrast Enhancement Imaging as a Potential Direct Marker of Coronary Involvement: Integration of Findings From CAD and SLE Patients.
[So] Source:JACC Cardiovasc Imaging;7(8):762-70, 2014 Aug.
[Is] ISSN:1876-7591
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVES: This study investigated the feasibility of visual and quantitative assessment of coronary vessel wall contrast enhancement (CE) for detection of symptomatic atherosclerotic coronary artery disease (CAD) and subclinical coronary vasculitis in autoimmune inflammatory disease (systemic lupus erythematosus [SLE]), as well as the association with aortic stiffness, an established marker of risk. BACKGROUND: Coronary CE by cardiac magnetic resonance (CMR) is a novel noninvasive approach to visualize gadolinium contrast uptake within the coronary artery vessel wall. METHODS: A total of 75 subjects (CAD: n = 25; SLE: n = 27; control: n = 23) underwent CMR imaging using a 3-T clinical scanner. Coronary arteries were visualized by a T2-prepared steady state free precession technique. Coronary wall CE was visualized using inversion-recovery T1 weighted gradient echo sequence 40 min after administration of 0.2 mmol/kg gadobutrol. Proximal coronary segments were visually examined for distribution of CE and quantified for contrast-to-noise ratio (CNR) and total CE area. RESULTS: Coronary CE was prevalent in patients (93%, n = 42) with a diffuse pattern for SLE and a patchy/regional distribution in CAD patients. Compared with control subjects, CNR values and total CE area in patients with CAD and SLE were significantly higher (mean CNR: 3.9 ± 2.5 vs. 6.9 ± 2.5 vs. 6.8 ± 2.0, respectively; p < 0.001; total CE area: median 0.8 [interquartile range (IQR): 0.6 to 1.2] vs. 3.2 [IQR: 2.6 to 4.0] vs. 3.3 [IQR: 1.9 to 4.5], respectively; p < 0.001). Both measures were positively associated with aortic stiffness (CNR: r = 0.61, p < 0.01; total CE area: 0.36, p = 0.03), hypercholesterolemia (r = 0.68, p < 0.001; r = 0.61, p < 0.001) and hypertension (r = 0.40, p < 0.01; r = 0.32, p < 0.05). CONCLUSIONS: We demonstrate that quantification of coronary CE by CNR and total CE area is feasible for detection of subclinical and clinical uptake of gadolinium within the coronary vessel wall. Coronary vessel wall CE may become an instrumental novel direct marker of vessel wall injury and remodeling in subpopulations at risk.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review

  6 / 32139 MEDLINE  
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[PMID]: 25076302
[Au] Autor:Muller K; Lin JH
[Ad] Address:From the Department of Pathology, UC San Diego, San Diego (Dr Muller), and the Department of Pathology, UC San Diego, La Jolla (Dr Lin), California.
[Ti] Title:Orbital granulomatosis with polyangiitis (wegener granulomatosis): clinical and pathologic findings.
[So] Source:Arch Pathol Lab Med;138(8):1110-4, 2014 Aug.
[Is] ISSN:1543-2165
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The pathology of granulomatosis with polyangiitis (GPA), formerly Wegener granulomatosis, typically features a granulomatous and sometimes necrotizing vasculitis targeting the respiratory tract and kidneys. However, orbital involvement occurs in up to 60% of patients and is frequently the first or only clinical presentation in patients with systemic or limited forms of GPA. Orbital GPA can cause significant morbidity and potentially lead to complete loss of vision and permanent facial deformity. Fortunately, GPA is highly responsive to medical treatment with corticosteroids combined with cyclophosphamide or, more recently, rituximab. Therefore, it is imperative for this disease to be accurately diagnosed on orbital biopsy and distinguished from other histologically similar orbital lesions. Herein, we review the clinical and pathologic findings of orbital GPA, focusing on the differentiation of this disease from other inflammatory orbital lesions.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review
[do] DOI:10.5858/arpa.2013-0006-RS

  7 / 32139 MEDLINE  
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[PMID]: 25007068
[Au] Autor:Zhang JL; Xu Y; Shen J
[Ad] Address:Department of Respiration, the First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310003, China. jianlizhangjj@163.com.
[Ti] Title:Cordycepin inhibits lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-α production via activating amp-activated protein kinase (AMPK) signaling.
[So] Source:Int J Mol Sci;15(7):12119-34, 2014.
[Is] ISSN:1422-0067
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Tumor necrosis factor (TNF)-α is elevated during the acute phase of Kawasaki disease (KD), which damages vascular endothelial cells to cause systemic vasculitis. In the current study, we investigated the potential role of cordycepin on TNFα expression in both lipopolysaccharide (LPS)-stimulated macrophages and ex vivo cultured peripheral blood mononuclear cells (PBMCs) of KD patients. We found that cordycepin significantly suppressed LPS-induced TNFα expression and production in mouse macrophages (RAW 264.7 cells and bone marrow-derived macrophages (BMDMs)). Meanwhile, cordycepin alleviated TNFα production in KD patients' PBMCs. PBMCs from healthy controls had a much lower level of basal TNF-α content than that of KD patients. LPS-induced TNF-α production in healthy controls' PBMCs was also inhibited by cordycepin. For the mechanism study, we discovered that cordycepin activated AMP-activated protein kinase (AMPK) signaling in both KD patients' PBMCs and LPS-stimulated macrophages, which mediated cordycepin-induced inhibition against TNFα production. AMPK inhibition by its inhibitor (compound C) or by siRNA depletion alleviated cordycepin's effect on TNFα production. Further, we found that cordycepin inhibited reactive oxygen species (ROS) production and nuclear factor kappa B (NF-κB) activation in LPS-stimulate RAW 264.7 cells or healthy controls' PBMCs. PBMCs of KD patients showed higher basal level of ROS and NF-κB activation, which was also inhibited by cordycepin co-treatment. In conclusion, our data showed that cordycepin inhibited TNFα production, which was associated with AMPK activation as well as ROS and NF-κB inhibition. The results of this study should have significant translational relevance in managing this devastating disease.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.3390/ijms150712119

  8 / 32139 MEDLINE  
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[PMID]: 24385592
[Au] Autor:Nakazawa D; Shida H; Tomaru U; Yoshida M; Nishio S; Atsumi T; Ishizu A
[Ad] Address:Department of Internal Medicine II and....
[Ti] Title:Enhanced formation and disordered regulation of NETs in myeloperoxidase-ANCA-associated microscopic polyangiitis.
[So] Source:J Am Soc Nephrol;25(5):990-7, 2014 May.
[Is] ISSN:1533-3450
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Microscopic polyangiitis (MPA) is an ANCA-associated vasculitis that affects small vessels, especially renal glomeruli. We recently demonstrated that the abnormal formation and impaired degradation of neutrophil extracellular traps (NETs) may be crucially involved in the generation of myeloperoxidase (MPO)-ANCA and subsequent development of MPA. This study assessed the formation and regulation of NETs in patients with MPO-ANCA-associated MPA. Peripheral blood samples were obtained from 38 patients with MPO-ANCA-associated MPA, 23 patients with systemic lupus erythematosus (SLE), and 8 healthy controls. IgG eluted from MPO-ANCA-associated MPA sera demonstrated the highest ability to induce NETs, and this ability correlated with disease activity and paralleled ANCA affinity for MPO. Moreover, addition of recombinant human MPO to these IgG samples reduced NET induction. Additionally, MPO-ANCA-associated MPA sera exhibited lower rates of NET degradation that recovered partially upon depletion of IgG. The activity of DNase I, an important regulator of NETs, was also lower in MPO-ANCA-associated MPA and SLE sera. IgG depletion from MPO-ANCA-associated MPA sera partially restored the rate of NET degradation, and addition of DNase I synergistically enhanced this restoration. Addition of anti-MPO antibodies did not inhibit DNase I activity, and some MPO-ANCA-associated MPA sera contained anti-NET antibodies at levels not correlated with MPO-ANCA titers, suggesting the involvement of unidentified autoantibodies as well. The collective evidence suggests a vicious cycle involving MPO-ANCA and the regulation of NETs could be critically involved in the pathogenesis of MPO-ANCA-associated MPA.
[Mh] MeSH terms primary: Antibodies, Antineutrophil Cytoplasmic/biosynthesis
Immunoglobulin G/biosynthesis
Immunoglobulin G/physiology
Microscopic Polyangiitis/immunology
Neutrophils/immunology
Peroxidase/metabolism
Up-Regulation/immunology
[Mh] MeSH terms secundary: Adult
Aged
Aged, 80 and over
Antibody Affinity
Case-Control Studies
Deoxyribonuclease I/metabolism
Female
Humans
Male
Microscopic Polyangiitis/enzymology
Middle Aged
Neutrophils/enzymology
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Antibodies, Antineutrophil Cytoplasmic); 0 (Immunoglobulin G); EC 1.11.1.7 (Peroxidase); EC 3.1.21.1 (Deoxyribonuclease I)
[Em] Entry month:1408
[Js] Journal subset:IM
[Da] Date of entry for processing:140625
[St] Status:MEDLINE
[do] DOI:10.1681/ASN.2013060606

  9 / 32139 MEDLINE  
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[PMID]: 24712892
[Au] Autor:Vanhaverbeke M; Sarens T; Driessche LV
[Ti] Title:Friable coronary arteries are link between pathogenesis and treatment of spontaneous coronary artery dissection.
[So] Source:Acta Clin Belg;69(3):217-20, 2014 Jun.
[Is] ISSN:1784-3286
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Spontaneous coronary artery dissection (SCAD) is increasingly being diagnosed as the cause of an acute coronary syndrome, especially in young patients. We report the case of a 32-year-old woman with postpartum SCAD of the left main and left anterior descending coronary artery which required the implantation of two drug-eluting stents. We present a literature study that correlates the pathogenesis of SCAD to the treatment options. Non-atherosclerotic SCAD is clearly associated with connective tissue disorders, vasculitis, and the peripartum period with its hormonal and haemodynamic changes. The coronary arteries of these SCAD patients are friable and should be approached with caution. Percutaneous coronary intervention has a reported success rate of only 65% and may cause propagation of the dissection. Lately, more and more authors suggest the possibility of a conservative approach in the absence of remaining cardiac ischaemia, even in this era of percutaneous stent implantation.
[Mh] MeSH terms primary: Acute Coronary Syndrome/etiology
Coronary Vessel Anomalies/complications
Puerperal Disorders/etiology
Vascular Diseases/congenital
[Mh] MeSH terms secundary: Acute Coronary Syndrome/diagnosis
Acute Coronary Syndrome/therapy
Adult
Coronary Vessel Anomalies/diagnosis
Coronary Vessel Anomalies/therapy
Female
Humans
Puerperal Disorders/diagnosis
Puerperal Disorders/therapy
Vascular Diseases/complications
Vascular Diseases/diagnosis
Vascular Diseases/therapy
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[Da] Date of entry for processing:140617
[St] Status:MEDLINE
[do] DOI:10.1179/2295333714Y.0000000020

  10 / 32139 MEDLINE  
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[PMID]: 22964421
[Au] Autor:Rebahi H; Nejmi H; Abouelhassan T; Hasni K; Samkaoui MA
[Ad] Address:Department of Anesthesia and Intensive Care Medicine, Mohammed VI's University-Hospital of Marrakech, Cadi Ayyad University, Marrakech, Morocco. Electronic address: r-houssam@hotmail.com....
[Ti] Title:Severe envenomation by Cerastes cerastes viper: an unusual mechanism of acute ischemic stroke.
[So] Source:J Stroke Cerebrovasc Dis;23(1):169-72, 2014 Jan.
[Is] ISSN:1532-8511
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Cerebral complications after snake bites--particularly ischemic complications--are rare. Very few cases of cerebral infarction resulting from a viper bite have been reported, and we call attention to this uncommon etiology. We discuss 3 authenticated reports of acute ischemic cerebrovascular accidents after 3 typical severe envenomations by Cerastes cerastes vipers. The 3 patients developed extensive local swelling and life-threatening systemic envenomation characterized by disseminated intravascular coagulopathy, increased fibrinolysis, thrombocytopenia, microangiopathic hemolytic anemia, and acute renal failure. This clinical picture involved atypical neurologic manifestations. These patients had either low Glasgow Coma Scale (GCS) or hemiparesis within hours to 4 days after being bitten, and they were found to have computed tomographic evidence of single or multiple ischemic (nonhemorrhagic) strokes of small- to large-vessel territories of the brain. One patient had good clinical recovery without neurologic deficits. Thrombotic complications occurred an average of 36 hours after being bitten, and their importance depends on the degree of envenomation. The possible mechanisms for cerebral infarction in these cases include generalized prothrombotic action of the venom (consumptive coagulopathy), toxin-induced vasculitis, and endothelial damage.
[Mh] MeSH terms primary: Brain Ischemia/etiology
Snake Bites/complications
Stroke/etiology
Viperidae
[Mh] MeSH terms secundary: Adult
Animals
Blood Coagulation Disorders/chemically induced
Brain/radiography
Brain Ischemia/radiography
Child, Preschool
Fatal Outcome
Female
Glasgow Coma Scale
Humans
Intracranial Thrombosis/etiology
Male
Middle Aged
Stroke/radiography
Tomography, X-Ray Computed
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[Da] Date of entry for processing:140106
[St] Status:MEDLINE


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