Database : MEDLINE
Search on : Vasculitis [Words]
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[PMID]: 25101798
[Au] Autor:Shendre A; Wiener HW; Zhi D; Vazquez AI; Portman MA; Shrestha S
[Ad] Address:Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA....
[Ti] Title:High-density genotyping of immune loci in Kawasaki disease and IVIG treatment response in European-American case-parent trio study.
[So] Source:Genes Immun;15(8):534-42, 2014 Dec.
[Is] ISSN:1476-5470
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Kawasaki disease (KD) is a diffuse and acute small-vessel vasculitis observed in children, and has genetic and autoimmune components. We genotyped 112 case-parent trios of European decent (confirmed by ancestry informative markers) using the immunoChip array, and performed association analyses with susceptibility to KD and intravenous immunoglobulin (IVIG) non-response. KD susceptibility was assessed using the transmission disequilibrium test, whereas IVIG non-response was evaluated using multivariable logistic regression analysis. We replicated single-nucleotide polymorphisms (SNPs) in three gene regions (FCGR, CD40/CDH22 and HLA-DQB2/HLA-DOB) that have been previously associated with KD and provide support to other findings of several novel SNPs in genes with a potential pathway in KD pathogenesis. SNP rs838143 in the 3'-untranslated region of the FUT1 gene (2.7 × 10(-5)) and rs9847915 in the intergenic region of LOC730109 | BRD7P2 (6.81 × 10(-7)) were the top hits for KD susceptibility in additive and dominant models, respectively. The top hits for IVIG responsiveness were rs1200332 in the intergenic region of BAZ1A | C14orf19 (1.4 × 10(-4)) and rs4889606 in the intron of the STX1B gene (6.95 × 10(-5)) in additive and dominant models, respectively. Our study suggests that genes and biological pathways involved in autoimmune diseases have an important role in the pathogenesis of KD and IVIG response mechanism.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1412
[Cu] Class update date: 141206
[Lr] Last revision date:141206
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1038/gene.2014.47

  2 / 32594 MEDLINE  
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[PMID]: 25207681
[Au] Autor:Hamedi M; Bergmeier LA; Hagi-Pavli E; Vartoukian SR; Fortune F
[Ad] Address:Centre Clinical and Diagnostic Oral Sciences, Institute of dentistry, Bart's and The London School of Medicine and Dentistry, London, UK.
[Ti] Title:Differential expression of suppressor of cytokine signalling proteins in Behçet's disease.
[So] Source:Scand J Immunol;80(5):369-76, 2014 Nov.
[Is] ISSN:1365-3083
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Behçet's disease (BD) is a chronic, multisystemic, recurrent vasculitis disease of unknown aetiology. Proinflammatory cytokines are a key feature of the disease, but the triggers for their induction are not well understood and/or controversial. Suppressor of cytokine signalling (SOCS) proteins which negatively regulate the JAK-STAT signalling pathway of cytokine induction may be dysregulated in BD. The expression of SOCS1 and 3 mRNA and protein was studied in peripheral blood mononuclear cells (PBMCs) and neutrophils of patients with BD and compared with healthy controls (HCs) and patients with recurrent aphthous stomatitis (RAS) using RT-PCR, Western blot and immunohistochemistry. SOCS1 and 3 mRNA was also measured in buccal mucosal cells (BMC) of patients with BD and HCs. SOCS1 and 3 mRNA was significantly upregulated in PBMCs of patients with BD compared with HCs (P = 0.0149; P = 0.0007). In addition, there were subtle differences between expression in active and symptom-free BD (quiescent BD). SOCS1 and SOCS 3 were also significantly upregulated in BMC from oral ulcers of BD compared with HCs (both at P = 0.0001). A differential expression of both SOCS1 and 3 was observed between PBMCs and neutrophils in patients with BD. Immunohistochemical analysis revealed differential expression of SOCS proteins in the buccal mucosa with an increased expression at the ulcer surface of ulcers than in the non-ulcerated tissue. These observations suggest a dysregulation of the expression of these important regulators not only between patients with BD and healthy controls but also between mucosal and systemic tissues, which may reflect the nature of the aetiopathology of the disease.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1410
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1111/sji.12211

  3 / 32594 MEDLINE  
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[PMID]: 25391370
[Au] Autor:Schirmer JH; Holl-Ulrich K; Moosig F
[Ad] Address:Klinik für Rheumatologie und Immunologie, Universitätsklinikum Schleswig-Holstein und Vaskulitisklinik, Klinikum Bad Bramstedt, Oskar-Alexander-Str. 26, 24576, Bad Bramstedt, Deutschland, j.schirmer@klinikumbb.de.
[Ti] Title:Polyarteriitis nodosa : Differenzialdiagnostik und Therapie. [Polyarteritis nodosa : Differential diagnostics and therapy].
[So] Source:Z Rheumatol;73(10):917-27, 2014 Dec.
[Is] ISSN:1435-1250
[Cp] Country of publication:Germany
[La] Language:ger
[Ab] Abstract:Polyarteritis nodosa (PAN) is a necrotizing vasculitis of medium size arteries that may affect various organs. The clinical appearance is very variable. The most common manifestations are of the skin, the peripheral nervous system presenting as mononeuritis multiplex and the mesenteric and renal blood vessels due to the development of stenoses and small aneurysms. Of the cases one third are estimated to be associated with hepatitis B virus (HBV). The therapy depends on the pathogenesis of the disease: primary PAN is treated with immunosuppressants, whereas patients with HBV-related PAN should receive antiviral therapy and plasmapheresis. Differentiating PAN from other forms of vasculitis can be difficult and requires complex differential diagnostics.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1412
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s00393-014-1483-z

  4 / 32594 MEDLINE  
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[PMID]: 25457357
[Au] Autor:Naouli H; Zrihni Y; Jiber H; Bouarhroum A
[Ad] Address:Service de chirurgie vasculaire périphérique F4, faculté de médecine et de pharmacie de Fès, CHU Hassan II, Fès, Maroc. Electronic address: naoulihamza@hotmail.fr....
[Ti] Title:Un anévrysme de l'aorte abdominale révélant une maladie de Behçet. [An abdominal aortic aneurysm revealing Behçet's disease].
[So] Source:J Mal Vasc;39(6):434-8, 2014 Dec.
[Is] ISSN:0398-0499
[Cp] Country of publication:France
[La] Language:fre
[Ab] Abstract:Behçet's disease is a vasculitis of unknown origin. Vascular lesions predominantly affect veins. Arterial involvement is rare but usually associated with poor prognosis. Aortic syndromes are usually aneurysmal and occasionally reveal Behçet's disease. We report the case of a 46-year-old man whose Behçet's disease was revealed by a sub-renal abdominal aortic aneurysm in pre-rupture state. The diagnosis of this disease was retained based on clinical, biological and radiological criteria. The surgical procedure consisted in the resection of the aneurysmal sac and the interposition of a prosthetic PTFE tube.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1412
[Js] Journal subset:IM
[St] Status:In-Data-Review

  5 / 32594 MEDLINE  
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[PMID]: 25455551
[Au] Autor:Hachicha F; Brour J; Zahaf A; Ben Abdallah M; Ouederni M; Cheour M; Kraiem A
[Ad] Address:Service d'ophtalmologie, hôpital Habib Thameur, rue de Bab el falah, 2004 Tunis, Tunisie; Faculté de médecine de Tunis, université Tunis El Manar, Tunis, Tunisie. Electronic address: firashchicha@yahoo.fr....
[Ti] Title:Le profil évolutif d'une atteinte oculaire rare et grave de la granulomatose de Wegener (GW) : la vasculite rétinienne occlusive. [Progression of a rare and serious ocular manifestation of Wegener's granulomatosis: Occlusive retinal vasculitis].
[So] Source:J Fr Ophtalmol;37(10):e153-5, 2014 Dec.
[Is] ISSN:1773-0597
[Cp] Country of publication:France
[La] Language:fre
[Pt] Publication type:LETTER
[Em] Entry month:1412
[Js] Journal subset:IM
[St] Status:In-Data-Review

  6 / 32594 MEDLINE  
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[PMID]: 25455143
[Au] Autor:Beaujeux P; Cloché V; Tréchot F; Conart JB; Angioi-Duprez K
[Ad] Address:Département d'ophtalmologie, hôpital Brabois, CHU de Nancy, avenue Morvan, 54511 VandÅ“uvre-lès-Nancy cedex, France....
[Ti] Title:Mise au point sur le syndrome de Susac. À propos d'un cas pédiatrique. [Focus on Susac's syndrome. A pediatric case report].
[So] Source:J Fr Ophtalmol;37(10):804-11, 2014 Dec.
[Is] ISSN:1773-0597
[Cp] Country of publication:France
[La] Language:fre
[Ab] Abstract:INTRODUCTION: Susac's syndrome (SS) is a rare immune disorder. It combines encephalopathy, retinopathy and hearing loss. We report a new pediatric case, revealed by an occlusive retinal arteritis. CASE REPORT: A 12-year-old girl presented to the emergency room because of sudden onset of photopsias in her right temporal visual field. One year previously, she had developed an acute disseminated encephalomyelitis, resolving with steroids. Visual acuity was 10/10-P2 in both eyes. Fundus examination revealed a thin right inferior nasal artery. Fluorescein angiography revealed an occlusion of this artery and occlusive peripheral arterial vasculitis. An IV steroid bolus was administered urgently. Brain MRI showed high signal intensity abnormalities in the corpus callosum. The clinical triad was rapidly completed by a bilateral hearing loss. Intravenous immunoglobulins were initiated. The occurrence of contralateral occlusive retinal arteritis two months later led to treatment with cyclophosphamide. After 6 infusions, visual acuity was stable, but the visual field remained, and regression of the vasculitis remained incomplete. DISCUSSION: Three hundred cases of SS have been reported with predominance in young women. Pediatric cases are rare. Diagnosis is difficult, because the typical clinical triad is often incomplete. Occurrence of relapses is unpredictable. Visual prognosis depends on the location of the occluded retinal territories. Treatment, based on a combination of steroids, immunosuppressive and antiplatelet agents is not always able to prevent relapse, as in our case. CONCLUSION: Unpredictable progression of SS requires early diagnosis and treatment as well as close monitoring. It must always be considered in the case of any occlusive retinal arteritis, even in children.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1412
[Js] Journal subset:IM
[St] Status:In-Data-Review

  7 / 32594 MEDLINE  
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[PMID]: 25474432
[Au] Autor:Huerva V; Ascaso FJ; Grzybowski A
[Ad] Address:From the Department of Ophthalmology (VH), University Hospital Arnau de Vilanova; IRB Lleida (VH), Lleida; Department of Ophthalmology, "Lozano Blesa" University Clinic Hospital (FJA); Instituto Aragonés de Ciencias de la Salud (FJA), Zaragoza, Spain; and Department of Ophthalmology (AG), Poznan City Hospital, Poznan, Poland.
[Ti] Title:Infliximab for peripheral ulcerative keratitis treatment.
[So] Source:Medicine (Baltimore);93(26):e176, 2014 Nov.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Biologic agents such as anti-TNFα have been employed in treatment paradigms for ocular inflammation. Peripheral corneal ulceration (PUK) is a devastating disorder consisting of a crescent-shaped area of destructive inflammation at the margin of the corneal stroma. It is associated with an epithelial defect, the presence of stromal inflammatory cells, and progressive stromal degradation and thinning, leading to ocular perforation and devastating visual loss. Macroulcerative PUK is usually a local manifestation of a systemic vasculitis. In many cases, the disease may be resistant to high doses of systemic corticosteroids and immunosuppressants. Chimeric anti-TNFα has been employed when all other treatments have failed. Isolated cases and short series of cases have been reported. This paper summarizes the available reports on the use, efficacy, and safety of infliximab in the treatment of PUK.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1412
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review
[do] DOI:10.1097/MD.0000000000000176

  8 / 32594 MEDLINE  
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[PMID]: 24243925
[Au] Autor:Robson J; Doll H; Suppiah R; Flossmann O; Harper L; Höglund P; Jayne D; Mahr A; Westman K; Luqmani R
[Ad] Address:Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science (NDORMs), University of Oxford, Oxford, USA Rheumatology Department, Nuffield Orthopaedic Centre, Oxford, UK....
[Ti] Title:Damage in the anca-associated vasculitides: long-term data from the European Vasculitis Study group (EUVAS) therapeutic trials.
[So] Source:Ann Rheum Dis;74(1):177-84, 2015 Jan.
[Is] ISSN:1468-2060
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVES: To describe short-term (up to 12 months) and long-term (up to 7 years) damage in patients with newly diagnosed antineutrophil-cytoplasm antibody-associated vasculitis (AAV). METHODS: Data were combined from six European Vasculitis Study group trials (n=735). Long-term follow-up (LTFU) data available for patients from four trials (n=535). Damage accrued was quantified by the Vasculitis Damage Index (VDI). Sixteen damage items were defined a priori as being potentially treatment-related. RESULTS: VDI data were available for 629 of 735 patients (85.6%) at baseline, at which time 217/629 (34.5%) had ≥1 item of damage and 32 (5.1%) ≥5 items, reflecting disease manifestations prior to diagnosis and trial enrolment. LTFU data were available for 467/535 (87.3%) at a mean of 7.3 years postdiagnosis. 302/535 patients (56.4%) had VDI data at LTFU, with 104/302 (34.4%) having ≥5 items and only 24 (7.9%) no items of damage. At 6 months and LTFU, the most frequent items were proteinuria, impaired glomerular filtration rate, hypertension, nasal crusting, hearing loss and peripheral neuropathy. The frequency of damage, including potentially treatment-related damage, rose over time (p<0.01). At LTFU, the most commonly reported items of treatment-related damage were hypertension (41.5%; 95% CI 35.6 to 47.4%), osteoporosis (14.1%; 9.9 to 18.2%), malignancy (12.6%; 8.6 to 16.6%), and diabetes (10.4%; 6.7 to 14.0%). CONCLUSIONS: In AAV, renal, otolaryngological and treatment-related (cardiovascular, disease, diabetes, osteoporosis and malignancy) damage increases over time, with around one-third of patients having ≥5 items of damage at a mean of 7 years postdiagnosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1412
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1136/annrheumdis-2013-203927

  9 / 32594 MEDLINE  
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[PMID]: 24981218
[Au] Autor:Arora A; Wetter DA; Gonzalez-Santiago TM; Davis MD; Lohse CM
[Ad] Address:Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC....
[Ti] Title:Incidence of leukocytoclastic vasculitis, 1996 to 2010: a population-based study in olmsted county, Minnesota.
[So] Source:Mayo Clin Proc;89(11):1515-24, 2014 Nov.
[Is] ISSN:1942-5546
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To determine the population-based incidence of leukocytoclastic vasculitis (LCV). PATIENTS AND METHODS: This is a retrospective population-based study of all Olmsted County, Minnesota, residents with a skin biopsy-proven diagnosis of LCV from January 1, 1996, through December 31, 2010. RESULTS: A total of 84 patients (mean age at diagnosis, 48.3 years) with newly diagnosed skin biopsy-proven LCV (43 women and 41 men) were identified. The incidence rate (age and sex adjusted to the 2000 US white population) was 4.5 per 100,000 person-years (95% CI, 3.5-5.4). The incidence of LCV increased significantly with age at diagnosis (P<.001) and did not differ between female and male patients. Subtypes of LCV were cutaneous small-vessel vasculitis (CSVV), 38 patients (45%); IgA vasculitis, 25 (30%); urticarial vasculitis, 10 (12%); cryoglobulinemic vasculitis, 3 (4%); and antineutrophil cytoplasmic antibody-associated vasculitis, 8 (10%). LCV was idiopathic in 29 of 38 patients with CSVV (76%) and 24 of 25 patients with IgA vasculitis (96%). Thirty-nine of 84 patients (46%) had systemic involvement, with the renal system most commonly involved (17 of 39 [44%]). Twenty-four of 80 patients (30%) with follow-up data available had recurrent disease. Compared with the Minnesota white population, observed survival in the incident LCV cohort was significantly poorer than expected (P<.001), including the subset of patients with idiopathic CSVV (P=.03). CONCLUSION: The incidence of LCV was higher than that reported in previously published studies. Idiopathic LCV was more common in our population-based cohort than that described previously. Overall survival was significantly poorer (P<.001) and should be explored further in future studies.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1412
[Cu] Class update date: 141204
[Lr] Last revision date:141204
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review

  10 / 32594 MEDLINE  
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[PMID]: 23344748
[Au] Autor:Aboukhoudir F; Pansieri M; Rekik S
[Ad] Address:Department of Cardiology, Avignon Hospital Center, Avignon, France.
[Ti] Title:Chronic calcific constrictive pericarditis complicating Churg-Strauss syndrome: first reported case.
[So] Source:Thorac Cardiovasc Surg;62(7):631-3, 2014 Oct.
[Is] ISSN:1439-1902
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Churg-Strauss syndrome is a necrotizing systemic vasculitis characterized by extravascular granulomas and eosinophilic infiltrates of small vessels. Although cardiac complications are considered to be relatively common, no case of constrictive calcified pericarditis has ever been previously described in this setting. In this report, we present the case of a 46-year-old man with Churg-Strauss syndrome, in whom we were able to document the development of symptomatic calcific constrictive pericarditis during a 10-year period despite long-term corticosteroid therapy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1410
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1055/s-0032-1331579


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