Database : MEDLINE
Search on : Vasculitis [Words]
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[PMID]: 26802238
[Au] Autor:Li JL; Lim CH; Tay FW; Goh CC; Devi S; Malleret B; Lee B; Bakocevic N; Chong SZ; Evrard M; Tanizaki H; Lim HY; Russell B; Renia L; Zolezzi F; Poidinger M; Angeli V; St John AL; Harris JE; Tey HL; Tan SM; Kabashima K; Weninger W; Larbi A; Ng LG
[Ad] Address:Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore....
[Ti] Title:Neutrophils Self-Regulate Immune Complex-Mediated Cutaneous Inflammation through CXCL2.
[So] Source:J Invest Dermatol;136(2):416-24, 2016 Feb.
[Is] ISSN:1523-1747
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Deposition of immune complexes (ICs) in tissues triggers acute inflammatory pathology characterized by massive neutrophil influx leading to edema and hemorrhage, and is especially associated with vasculitis of the skin, but the mechanisms that regulate this type III hypersensitivity process remain poorly understood. Here, using a combination of multiphoton intravital microscopy and genomic approaches, we re-examined the cutaneous reverse passive Arthus reaction and observed that IC-activated neutrophils underwent transmigration, triggered further IC formation, and transported these ICs into the interstitium, whereas neutrophil depletion drastically reduced IC formation and ameliorated vascular leakage invivo. Thereafter, we show that these neutrophils expressed high levels of CXCL2, which further amplified neutrophil recruitment and activation in an autocrine and/or paracrine manner. Notably, CXCL1 expression was restricted to tissue-resident cell types, but IC-activated neutrophils may also indirectly, via soluble factors, modulate macrophage CXCL1 expression. Consistent with their distinct cellular origins and localization, only neutralization of CXCL2 but not CXCL1 in the interstitium effectively reduced neutrophil recruitment. In summary, our study establishes that neutrophils are able to self-regulate their own recruitment and responses during IC-mediated inflammation through a CXCL2-driven feed forward loop.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1601
[Js] Journal subset:IM
[St] Status:In-Data-Review

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[PMID]: 26386466
[Au] Autor:Hutu DP; Tuddenham E; Monogioudi E; Meroni P; Schimmel H; Sheldon J; Zegers I; collaborating laboratories
[Ad] Address:Institute for Reference Materials and Measurements (IRMM), Joint Research Centre, European Commission, Geel, Belgium....
[Ti] Title:First steps in the standardization of immunoglobulin IgG myeloperoxidase-anti-neutrophil cytoplasmic antibody measurements.
[So] Source:Clin Exp Immunol;183(2):193-205, 2016 Feb.
[Is] ISSN:1365-2249
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The standardization of immunoassays for immunoglobulin (Ig)G myeloperoxidase-anti-neutrophil cytoplasmic antibodies (MPO-ANCA) could contribute to a more accurate diagnosis and follow-up of small vessels-associated vasculitis, a systemic autoimmune disorder that leads to necrosis of blood vessel walls. Despite significant efforts by different groups, the level of comparability of results from commercially available immunoassays used for IgG MPO-ANCA detection is still poor. Therefore, the potential for improvement using reference materials was assessed. The evaluation of a set of 30 patient samples with 11 assays showed that differences between assays result in different interpretations for individual patients. Only 10 of 30 patient samples had the same clinical interpretation among 11 assays applying the cut-off values provided by each respective manufacturer. The correlation between results from 13 different assays was assessed in a pairwise manner. The correlation between results from patient samples was systematically very good for combinations of seven of those assays. The correlation of results ranged from reasonable to good for combinations with four other assays, therefore it should be possible to improve the comparability of results using a commutable reference material for calibration. Feasibility studies were conducted in order to find a reference material format most suitable for a calibrator. Two sets of candidate reference materials were produced from different raw materials, and assessed according to their suitability. A final format was selected, and a candidate reference material was produced.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1601
[Cu] Class update date: 160123
[Lr] Last revision date:160123
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/cei.12707

  3 / 34439 MEDLINE  
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[PMID]: 26403285
[Au] Autor:Misra DP; Agarwal V
[Ad] Address:Department of Clinical Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Rae Bareily Road, Lucknow, Uttar Pradesh, 226 014, India. durgapmisra@gmail.com.
[Ti] Title:Innate immune cells in the pathogenesis of primary systemic vasculitis.
[So] Source:Rheumatol Int;36(2):169-82, 2016 Feb.
[Is] ISSN:1437-160X
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Innate immune system forms the first line of defense against foreign substances. Neutrophils, eosinophils, erythrocytes, platelets, monocytes, macrophages, dendritic cells, γδ T cells, natural killer and natural killer T cells comprise the innate immune system. Genetic polymorphisms influencing the activation of innate immune cells predispose to development of vasculitis and influence its severity. Abnormally activated innate immune cells cross-talk with other cells of the innate immune system, present antigens more efficiently and activate T and B lymphocytes and cause tissue destruction via cell-mediated cytotoxicity and release of pro-inflammatory cytokines. These secreted cytokines further recruit other cells to the sites of vascular injury. They are involved in both the initiation as well as the perpetuation of vasculitis. Evidences suggest reversal of aberrant activation of immune cells in response to therapy. Understanding the role of innate immune cells in vasculitis helps understand the potential of therapeutic modulation of their activation to treat vasculitis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1601
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s00296-015-3367-1

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[PMID]: 26198847
[Au] Autor:Mlakar J; Zorman JV; Maticic M; Vrabec M; Alibegovic A; Popovic M
[Ad] Address:Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia....
[Ti] Title:Central nervous system granulomastous phlebitis with limited extracranial involvement of the heart and lungs: An autopsy case.
[So] Source:Neuropathology;36(1):88-92, 2016 Feb.
[Is] ISSN:1440-1789
[Cp] Country of publication:Australia
[La] Language:eng
[Ab] Abstract:Primary angiitis of the central nervous system is a rare condition, usually with an insidious onset. There is a wide variety of histological types (granulomatous, lymphocytic or necrotizing vasculitis) and types of vessel involved (arteries, veins or both). Most cases are idiopathic. We describe a first case of idiopathic granulomatous central nervous system phlebitis with additional limited involvement of the heart and lung, exclusively affecting small and medium sized veins in a 22-year-old woman, presenting as a sub acute headache. The reasons for this peculiar limitation of inflammation to the veins and the involvement of the heart and lungs are unknown.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1601
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/neup.12234

  5 / 34439 MEDLINE  
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[PMID]: 26526463
[Au] Autor:Webster A; Walters G; Willis N; Craig J
[Ti] Title:Interventions for renal vasculitis in adults.
[So] Source:Nephrology (Carlton);21(2):156-8, 2016 Feb.
[Is] ISSN:1440-1797
[Cp] Country of publication:Australia
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1601
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/nep.12662

  6 / 34439 MEDLINE  
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[PMID]: 26400032
[Au] Autor:Singh S; Sharma A; Jiao F
[Ad] Address:Pediatric Allergy Immunology Unit, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. surjitsinghpgi@hotmail.com.
[Ti] Title:Kawasaki Disease: Issues in Diagnosis and Treatment - A Developing Country Perspective.
[So] Source:Indian J Pediatr;83(2):140-5, 2016 Feb.
[Is] ISSN:0973-7693
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:Kawasaki disease (KD) is a common vasculitis in children and is the commonest cause of pediatric acquired heart disease in children in Japan and countries in North America and the European Union. It is now being increasingly reported from several developing countries, including China and India. Diagnosis of KD is based on a set of clinical criteria, none of which is individually pathognomonic for this condition. Further, these clinical features appear sequentially over a few days and all findings may not be present at a given point of time. Like many other vasculitides, there is no confirmatory laboratory test for KD. Treatment of KD involves use of intravenous immunoglobulin (IVIg) and aspirin. IVIg is an expensive product and poses several difficulties for patients in developing countries who may find it difficult to access therapy even if a diagnosis of KD has been made in time. In this review, the authors discuss some of these challenges that pediatricians have to face while managing KD in resource constrained settings.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1601
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s12098-015-1890-4

  7 / 34439 MEDLINE  
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[PMID]: 26365154
[Au] Autor:Singh-Grewal D; Durkan AM
[Ad] Address:Department of Rheumatology, The Sydney Children's Hospitals Network, Corner of Hainsworth Street and Hawkesbury Roads, Westmead, Sydney, NSW, 2145, Australia. davinder.singhgrewal@health.nsw.gov.au.
[Ti] Title:Pediatric Vasculitis.
[So] Source:Indian J Pediatr;83(2):156-62, 2016 Feb.
[Is] ISSN:0973-7693
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:Vasculitis is defined as inflammation of the blood vessels and can result in stenosis or aneurysm, which may in turn lead to occlusion or rupture of the vessel compromising tissue perfusion. The manifestations of these diseases depend on the size and site of the vessels effected. Vasculitis can be secondary to numerous inflammatory and infectious diseases but this review will concentrate on the systemic primary vasculitides and aims to discuss the presentations and approaches to management of a number of these conditions.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1601
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s12098-015-1876-2

  8 / 34439 MEDLINE  
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[PMID]: 26800622
[Au] Autor:Harrington K; Phelan E; Torreggiani WC; Doody O
[Ad] Address:Radiology Department, The Adelaide and Meath Hospital Dublin, Incorporating the National Children's Hospital, Dublin, Ireland. Electronic address: harringtonkatea@gmail.com....
[Ti] Title:The Management of the Symptomatic Patient With a Metal-on-Metal Hip Prosthesis.
[So] Source:Can Assoc Radiol J;67(1):76-81, 2016 Feb.
[Is] ISSN:1488-2361
[Cp] Country of publication:Canada
[La] Language:eng
[Ab] Abstract:Metal-on-metal (MoM) hip implants have gained popularity due to their greater stability and reduction in implant failure compare to metal-on-polyethylene prostheses. However, as well as carrying general risks of hip implantation, risks specifically associated with MoM implants have been well documented in recent years. Conditions such as pseudotumours or aseptic lymphocyte-dominated vasculitis-associated lesions are specific to MoM hip implants. In this review we discuss the typical patient presentation, the investigations that should be performed, the typical findings on various imaging modalities, and the treatment options of symptomatic patients with MoM hip arthroplasties.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1601
[Js] Journal subset:IM
[St] Status:In-Data-Review

  9 / 34439 MEDLINE  
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[PMID]: 26174811
[Au] Autor:Steeples LR; Guiver M; Jones NP
[Ad] Address:Manchester Royal Eye Hospital, Manchester, UK.
[Ti] Title:Real-time PCR using the 529 bp repeat element for the diagnosis of atypical ocular toxoplasmosis.
[So] Source:Br J Ophthalmol;100(2):200-3, 2016 Feb.
[Is] ISSN:1468-2079
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Ocular toxoplasmosis may present in atypical fashion, particularly in immunosuppressed patients, and PCR is an important diagnostic tool especially when differentiating from other infectious causes. METHODS: A descriptive case-series demonstrating the use of a novel real-time PCR protocol targeting 529 bp repeat element, a multicopy and highly conserved fragment, in Toxoplasma gondii genome. This was designed and established by our microbiology service following independent, external validation. RESULTS: Three immunosuppressed patients presenting to a tertiary uveitis referral centre with unilateral, severe, sight-threatening uveitis are described. One patient presented with a large focus of sight-threatening retinitis and occlusive vasculitis while on systemic immunosuppression with azathioprine and adalimumab for Crohn's disease. One patient with chronic lymphocytic leukaemia presented with severe posterior uveitis and total retinal detachment. Finally, the third patient presented with severe retinitis adjacent to the optic nerve and vitritis causing acute vision loss. HIV infection was subsequently identified. In all three cases, the cause of inflammation was not clear from clinical examination alone and prompt treatment was required to prevent permanent vision loss. Intraocular sampling and PCR testing was performed including testing for toxoplasmosis, herpesviruses and syphilis. CONCLUSIONS: The novel real-time PCR assay described is more sensitive than those targeting the Toxoplasma B1 gene owing to the higher number of repeats and highly conserved sequence level. This technique can be applied in clinical practice and provides a valuable tool for the rapid diagnosis of ocular toxoplasmosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1601
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1136/bjophthalmol-2015-306801

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[PMID]: 26788412
[Au] Autor:Kim EJ; Lee SJ; Ahn EY; Ryu DG; Choi YH; Kim TH
[Ad] Address:Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea....
[Ti] Title:Relapsed Brucellosis Presenting as Neurobrucellosis with Cerebral Vasculitis in a Patient Previously Diagnosed with Brucellar Spondylitis: A Case Report.
[So] Source:Infect Chemother;47(4):268-71, 2015 Dec.
[Is] ISSN:2093-2340
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:Brucellosis is a multisystem disease with various clinical symptoms. Neurobrucellosis is a rare but serious manifestation of brucellosis. A 60-year-old man with a previous diagnosis of brucellar spondylitis presented with sudden onset of aphasia and numbness of the right upper extremity. Cerebral angiography showed diffuse narrowing and dilatation on the distal branches of both the anterior cerebral artery (ACA) and the left middle cerebral artery (MCA) which indicated cerebral vasculitis, and the patient's Brucella agglutinin titer was 1:1280. After combined antimicrobial and steroid therapy was started, the patient's condition improved significantly, and he was discharged after 1 month. Antimicrobial therapy was continued for 16 months on an outpatient basis, and the last Brucella agglutinin titer was 1:40. To our knowledge, this is the first case of relapsed neurobrucellosis with vasculitis in Korea to have been treated successfully.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1601
[Cu] Class update date: 160122
[Lr] Last revision date:160122
[Da] Date of entry for processing:160120
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.3947/ic.2015.47.4.268


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