Database : MEDLINE
Search on : Vasculitis [Words]
References found : 33612 [refine]
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[PMID]: 25256279
[Au] Autor:Criado PR; Grizzo Peres Martins AC; Gaviolli CF; Alavi A
[Ad] Address:University of São Paulo, São Paulo, Brazil....
[Ti] Title:Propylthiouracil-Induced Vasculitis With Antineutrophil Cytoplasmic Antibody.
[So] Source:Int J Low Extrem Wounds;14(2):187-91, 2015 Jun.
[Is] ISSN:1552-6941
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Propylthiouracil (PTU)-associated vasculitis is a potentially life-threatening disease with a recent increase in the reported cases in the medical literature. This increase may suggest that some earlier cases have been unrecognized or assigned to an alternative nosology category. Although the skin can be the only organ affected by PTU-associated vasculitis, there are many reports with multiple-system involvement. Classically, the symptoms appear under a tetrad of fever, sore throat, arthralgia, and skin lesions. Cutaneous lesions in reported cases of PTU vasculitis have most commonly consisted of retiform acral, purpuric plaques, or nodules. We report a case of perinuclear antineutrophil cytoplasmic antibody-associated vasculitis developed during treatment with PTU for Grave's disease.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1507
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1177/1534734614549418

  2 / 33612 MEDLINE  
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[PMID]: 24879461
[Au] Autor:Fino P; Onesti MG; Felli A; Scuderi N
[Ad] Address:"Sapienza" University of Rome, Rome, Italy pasquale.fino@uniroma1.it....
[Ti] Title:Clinical Examination and Treatment of a Leg Ulcer Caused by a Stingray Puncture.
[So] Source:Int J Low Extrem Wounds;14(2):183-6, 2015 Jun.
[Is] ISSN:1552-6941
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The most frequent causes of leg ulcers include venous incompetency (superficial and deep), arterial insufficiency, trauma, vasculitis, and neoplasm. Leg ulcers from injury by stingrays are quite rare. In this case report, we describe a leg ulcer caused by a stingray sting complicated by infection, which healed completely without surgery. In addition, since there few cases in the literature describing such traumas, we performed a comprehensive review of the literature. Important is the fact that the wound healing was complete without resorting to surgery, but only with a correct targeted antibiotic therapy and the use of a collagenase, which has the particularity of having hyaluronic acid as a component.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1507
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1177/1534734614536037

  3 / 33612 MEDLINE  
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[PMID]: 26181551
[Au] Autor:Tsai SY; Lin CL; Wong YC; Yang TY; Kuo CF; Cheng JM; Wang JS; Kao CH
[Ad] Address:From the Department of Laboratory Medicine, Mackay Memorial Hospital, Mackay Medical College, New Taipei City, Taiwan (S-YT); Department of Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University, USA (S-YT); Management Office for Health Data, China Medical University Hospital (C-LL); College of Medicine, China Medical University, Taichung (C-LL); Department of Medicine, National Defense Medical Center, Taipei (Y-CW); Molecular and Genomic Epidemiology Center, China Medical University Hospital, China Medical University, Taichung (T-YY); Division of Nephrology, Department of Internal Medicine, Changhua Christian Hospital, Changhua (T-YY); Division of Infectious Disease, Department of Medicine, Mackay Memorial Hospital (C-FK); Institute of Biomedical Engineering, National Taiwan University, Taipei (J-MC); Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung (J-SW); Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung (C-HK); and Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan (C-HK).
[Ti] Title:Increased Risk of Herpes Zoster Following Dermatomyositis and Polymyositis: A Nationwide Population-Based Cohort Study.
[So] Source:Medicine (Baltimore);94(28):e1138, 2015 Jul.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:This study explored the possible association between dermatomyositis or polymyositis (DM or PM) and the subsequent risk of herpes zoster (HZ).We used data from the Taiwan National Health Insurance (NHI) system to address the research topic. The exposure cohort comprised 2023 patients with new diagnoses of DM or PM. Each patient was frequency matched according to age, sex, index year, and comorbidities including diabetes, renal disease, obesity, malignancy, rheumatoid arthritis, immunodeficiency virus infection, autoimmune disease not elsewhere classified, mixed connective tissue disease, or vasculitis with 4 participants from the general population who did not have a history of HZ (control cohort). Cox proportional hazards regression analysis was conducted to estimate the relationship between DM or PM and the risk of subsequent HZ.The incidence of HZ in the exposure and control cohorts was 35.8 and 7.01 per 1000 person-years, respectively. The exposure cohort had a significantly higher overall risk of subsequent HZ than did the control cohort (adjusted hazard ratio [HR] = 3.90, 95% confidence interval [CI] = 3.18-4.77). The risk of HZ in patients with DM or PM in whichever stratification (including sex, age, and comorbidity) was also higher than that of the control cohort.The findings from this population-based retrospective cohort study suggest that DM or PM is associated with an increased risk of subsequent HZ. A synergistic effect was observed between DM or PM and one of the comorbidities.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1507
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review
[do] DOI:10.1097/MD.0000000000001138

  4 / 33612 MEDLINE  
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[PMID]: 25316727
[Au] Autor:Kurian M; Pereira VM; Vargas MI; Fluss J
[Ad] Address:Pediatric Neurology, Pediatric Subspecialties Service, Children's Hospital, Geneva, Switzerland mary.kurian@hcuge.ch....
[Ti] Title:Stroke-like Phenomena Revealing Multifocal Cerebral Vasculitis in Pediatric Lyme Neuroborreliosis.
[So] Source:J Child Neurol;30(9):1226-9, 2015 Aug.
[Is] ISSN:1708-8283
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Stroke-like presentation in Lyme neuroborreliosis is rare in the pediatric age group. We report a previously healthy 12-year-old boy who presented with acute left hemiparesis and meningeal signs. Neuroimaging failed to reveal any cerebral infarction but demonstrated a multifocal cerebral vasculitis involving small, medium and large-sized vessels affecting both the anterior and posterior circulation. Concentric contrast enhancement of the basilar artery was also observed. Further investigations and laboratory findings were consistent with Lyme neuroborreliosis. A rapidly favorable clinical outcome was obtained with appropriate antibiotic treatment along with antiaggregants and steroids. Lyme neuroborreliosis should be considered in the diagnostic differential, not only in adults but also among children, especially in the context of an unexplained cerebral vasculitis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1507
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1177/0883073814552104

  5 / 33612 MEDLINE  
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[PMID]: 25494839
[Au] Autor:Ajose FO; Adelowo O; Oderinlo O
[Ad] Address:Department of Medicine, Lagos State University Teaching Hospital, Lagos, Nigeria.
[Ti] Title:Clinical presentations of Behçet's disease among Nigerians: a 4-year prospective study.
[So] Source:Int J Dermatol;54(8):889-97, 2015 Aug.
[Is] ISSN:1365-4632
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Behçet's disease (BD) is a chronic, multisystem, inflammatory pan-vasculitis of unknown etiology, with heterogeneous presentations in different parts of the world. It commonly involves the mucosae, skin, joints, eyes, and central nervous system. Behçet's disease is considered to represent an autoimmune reaction triggered by a yet to be identified infectious agent in a genetically predisposed person. It most commonly affects persons of Mediterranean or Far Eastern origin and is considered rare among Black Africans. OBJECTIVES: This study was conducted to document clinical presentations of BD in Nigerians. METHODS: A prospective study of the clinical and laboratory parameters of patients who attended dermatology and rheumatology clinics between 2007 and 2011 was carried out. RESULTS: Fifteen patients (nine males, six females) were diagnosed with BD at a mean age of 33 years. The mean age of onset of disease was 27 years. Oral ulceration was present in 100% of subjects and was the most frequent onset lesion, followed by genital ulceration in 93%. Skin, joint, vascular, gastrointestinal, and central nervous system (CNS) lesions occurred in 87, 80, 33, 20, and 13% of patients, respectively. Pathergy tests were positive in 38% of patients. Psychomorbidity was present in 60%. Remission was achieved with corticosteroids, nonsteroidal anti-inflammatory drugs, and disease-modifying anti-rheumatic drugs. Mortality was zero, but 27% of patients were disabled by blindness and 7% by CNS involvement. CONCLUSIONS: This is the first report on BD in a sample of Nigerians. The clinical phenotype of BD follows the Middle Eastern pattern. The small number of patients may reflect the rarity of BD in Nigerians or the poor ascertainment of BD by relevant clinicians.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1507
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/ijd.12554

  6 / 33612 MEDLINE  
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[PMID]: 26039457
[Au] Autor:van Koppen CJ; Hartmann RW
[Ad] Address:ElexoPharm GmbH , Im Stadtwald, Building A1.2, 66123 Saarbrücken , Germany +49 681 30268320 ; +49 681 9102894 ; vankoppen@elexopharm.de.
[Ti] Title:Advances in the treatment of chronic wounds: a patent review.
[So] Source:Expert Opin Ther Pat;25(8):931-7, 2015 Aug.
[Is] ISSN:1744-7674
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:INTRODUCTION: About 2% of the Western world population suffer from chronic wounds, resulting from underlying disorders (e.g., diabetes, excessive pressure, vascular insufficiencies and vasculitis), with a significant adverse effect on Quality of Life. Despite high incidence and economic burden, management of chronic wounds is still far from effective and novel therapies are in urgent need. Wound healing is a dynamic process of transient expression, function and clearance of mediators, enzymes and cell types. Failure to initiate, terminate or regulate leads to pathologic wound healing. AREAS COVERED: The present review discusses patents of the seven most promising classes of biological agents, mostly published in 2009 - 2014 (CYP11B1 inhibitors, peptide growth factors, prolyl-4-hydroxylase and matrix metalloproteinase inhibitors, bone marrow-derived mesenchymal stem cells, elastase and connexin43 inhibitors). Relevant information from peer-reviewed journals is also presented. EXPERT OPINION: The aforementioned biological agents have different mechanisms of action, and considering the multifactorial pathogenesis of chronic wounds, they hold promise in treating chronic wounds. However, as administration of a certain biological agent may be beneficial in an early phase, it may slow down wound healing in a later phase. Basic and clinical research on chronic wound healing should therefore investigate the efficacy of these agents, alone and in concert, during the consecutive phases of wound healing.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1507
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1517/13543776.2015.1045879

  7 / 33612 MEDLINE  
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[PMID]: 26184020
[Au] Autor:DeFilippis EM; Magro C; Jorizzo JL
[Ad] Address:Weill Cornell Medical College, New York, NY, USA, ersilia.defilippis15@gmail.com.
[Ti] Title:Bowel-associated dermatosis - arthritis syndrome in a patient with ulcerative colitis: an extraintestinal manifestation of inflammatory bowel disease.
[So] Source:Clin J Gastroenterol;7(5):410-3, 2014 Oct.
[Is] ISSN:1865-7265
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:Bowel-associated dermatosis - arthritis syndrome (BADAS) is a neutrophilic dermatosis characterized by cutaneous lesions that begin as erythematous macules and progress to vesiculopustular eruptions. It has been described in patients with inflammatory bowel disease as well as those who have undergone various intestinal surgeries. Pathologically, the lesions show features of vasculitis without fibrinoid necrosis. In a patient with diagnosed inflammatory bowel disease, these neutrophilic dermatoses should be viewed as external signals of bowel inflammation. Management requires long-term treatment of the underlying disease. We report a case of BADAS in a patient with ulcerative colitis in which the skin lesions were associated with increased colonic inflammation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1507
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s12328-014-0529-8

  8 / 33612 MEDLINE  
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[PMID]: 25934819
[Au] Autor:McGeoch L; Carette S; Cuthbertson D; Hoffman GS; Khalidi N; Koening CL; Langford CA; McAlear CA; Moreland L; Monach PA; Seo P; Specks U; Ytterberg SR; Merkel PA; Pagnoux C; Vasculitis Clinical Research Consortium
[Ad] Address:From the Division of Rheumatology, Mount Sinai Hospital, Toronto, Ontario, Canada; Health Informatics Institute, University of South Florida, Tampa, Florida; Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, Ohio, USA; Division of Rheumatology, McMaster University, Hamilton, Onta...
[Ti] Title:Cardiac Involvement in Granulomatosis with Polyangiitis.
[So] Source:J Rheumatol;42(7):1209-12, 2015 Jul.
[Is] ISSN:0315-162X
[Cp] Country of publication:Canada
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To determine frequency and outcomes of granulomatosis with polyangiitis (GPA)-related cardiac disease in a North American GPA cohort. METHODS: Analysis was done of all patients in the Vasculitis Clinical Research Consortium Longitudinal Study of GPA. Demographic and clinical characteristics of patients with and without GPA-related cardiac involvement were compared. RESULTS: Of 517 patients with GPA, 3.3% had cardiac involvement. No differences were observed between patients with or without cardiac involvement in terms of demographics, antineutrophil cytoplasmic antibody positivity, or relapse rate. CONCLUSION: Cardiac involvement in GPA is rare and heterogeneous. In this cohort, cardiac involvement was not associated with a higher rate of relapse or premature death.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1507
[Cu] Class update date: 150717
[Lr] Last revision date:150717
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.3899/jrheum.141513

  9 / 33612 MEDLINE  
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[PMID]: 25048363
[Au] Autor:Milman N; Boonen A; Merkel PA; Tugwell P
[Ad] Address:Ottawa Hospital and University of Ottawa, Ottawa, Ontario, Canada.
[Ti] Title:Mapping of the outcome measures in rheumatology core set for antineutrophil cytoplasmic antibody-associated vasculitis to the International Classification of Function, Disability and Health.
[So] Source:Arthritis Care Res (Hoboken);67(2):255-63, 2015 Feb.
[Is] ISSN:2151-4658
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: The International Classification of Functioning, Disability and Health (ICF) is a framework and classification of health that describes health along 4 components: body functions, body structures, activities and participation, and contextual factors. This study examined the content of instruments that constitute the Outcome Measures in Rheumatology (OMERACT) core set of outcome measures for antineutrophil cytoplasmic antibody-associated vasculitis (AAV) by "mapping" them to the ICF. METHODS: The content of the instruments included in the AAV core set were linked to the ICF by 2 independent investigators according to previously established ICF linkage rules. RESULTS: The AAV core set includes 3 measures of disease activity (3 versions of the Birmingham Vasculitis Activity Score), 1 damage measure (Vasculitis Damage Index), 1 patient-reported outcome (Short Form 36 health survey), and death. Linking these instruments to the ICF revealed comprehensive coverage of the ICF components body functions and body structures, limited coverage of the ICF component activities and participation, and complete absence of coverage of contextual factors. CONCLUSION: ICF was found to be useful for thematic characterization of a heterogeneous group of outcome measures for AAV, i.e., a group of complex medical conditions. Linking of the instruments selected for the OMERACT AAV core set of outcome measures to the ICF classification revealed limitations in the representation of constructs related to life impact of AAV, represented by the ICF components activities and participation and contextual factors. Further research and methods development are needed to better incorporate important aspects of functioning and health relevant to patients into clinical trials of AAV.
[Mh] MeSH terms primary: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/classification
Outcome Assessment (Health Care)
Rheumatology
[Mh] MeSH terms secundary: Humans
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1503
[Cu] Class update date: 150717
[Lr] Last revision date:150717
[Js] Journal subset:IM
[Da] Date of entry for processing:150128
[St] Status:MEDLINE
[do] DOI:10.1002/acr.22414

  10 / 33612 MEDLINE  
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[PMID]: 26174904
[Au] Autor:Luban NL; Wong EC; Henrich Lobo R; Pary P; Duke S
[Ad] Address:Division of Laboratory Medicine, Children's National Medical Center, Washington, DC....
[Ti] Title:Intravenous immunoglobulin-related hemolysis in patients treated for Kawasaki disease.
[So] Source:Transfusion;55 Suppl 2:S90-4, 2015 Jul.
[Is] ISSN:1537-2995
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Kawasaki disease (KD) is an idiopathic, multisystem disorder characterized by vasculitis of arteries, veins, and capillaries, affecting pediatric patients, and is the leading cause of acquired heart disease in childhood. The mainstays of therapy for KD are high-dose intravenous immunoglobulin (IVIG) and aspirin, which are thought to prevent or modify the most serious cardiac sequelae. A well-documented complication of high-dose IVIG infusion in adults is hemolytic anemia due to passive transfer of anti-A and anti-B. Risk factors for hemolysis in another case series included patient blood group (group A, B, or AB), a high cumulative dose of IVIG, and concomitant inflammation documented by one or more markers like ferritin, fibrinogen, erythrocyte sedimentation rate, or C-reactive protein. STUDY DESIGN AND METHODS: A 3-year retrospective case review of patients previously recognized with apparent IVIG-related hemolytic anemia identified by standard blood bank testing was performed at a tertiary care pediatric hospital. RESULTS: Five patients were identified with severe anemia each requiring RBC transfusion for anemia. All five patients demonstrated a positive direct antiglobulin testing. Four of five patients had anti-A, anti-B, and/or anti-A1 with elution assays. All patients had signs of extravascular hemolysis with reticulocytosis, spherocytosis, and other hemolysis markers. One child died. CONCLUSION: Our cases represent dose-dependent hemolysis caused by IVIG in association with severe anemia requiring transfusion with an average yearly incidence rate of 0.36%. Hemolysis is an underrecognized complication of IVIG administration. KD patients are at greater risk for anemia because of their lower baseline hemoglobin concentration, underlying acute inflammation, and oxygen requirements during acute illness.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1507
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/trf.13089


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