Database : MEDLINE
Search on : Vasculitis [Words]
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[PMID]: 27796482
[Au] Autor:Witte T
[Ad] Address:Klinik für Immunologie und Rheumatologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland. Witte.torsten@mh-hannover.de.
[Ti] Title:Einsatz von Immunglobulinen. [Therapeutic administration of immunoglobulins].
[So] Source:Z Rheumatol;, 2016 Oct 31.
[Is] ISSN:1435-1250
[Cp] Country of publication:Germany
[La] Language:GER
[Ab] Abstract:BACKGROUND: Intravenously administered immunoglobulins have multiple modes of action that are anti-inflammatory. They can therefore be beneficial in a number of autoimmune disorders. OBJECTIVE: The aim of this article is to analyze and summarize studies on the administration of intravenous immunoglobulins in rheumatological diseases. METHODS: A selective search and analysis of the literature was carried out related to the mode of action and efficacy of intravenous immunoglobulins in rheumatological diseases. RESULTS AND CONCLUSION: Intravenous immunoglobulins have a broad mode of action and can therefore be beneficial in almost all autoimmune diseases. Conditions in which they are of special benefit include immunothrombopenia (ITP), Kawasaki disease and idiopathic inflammatory myopathies. In rare situations, they may also be indicated in systemic lupus erythematosus (SLE), Sjögren's syndrome and neuropathies, catastrophic antiphospholipid syndrome (APS), scleroderma, antineutrophil cytoplasmic antibody (ANCA) associated vasculitis, pyoderma gangrenosum and scleromyxedema. Severe adverse events are rare. In view of the high costs of the therapy, intravenous immunoglobulins are mostly applied in emergency situations, as salvage therapy when other standard therapies have failed or when severe infections are a contraindication to the administration of immunosuppressants.
[Pt] Publication type:JOURNAL ARTICLE; ENGLISH ABSTRACT
[Em] Entry month:1610
[Cu] Class update date: 161031
[Lr] Last revision date:161031
[St] Status:Publisher

  2 / 36426 MEDLINE  
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[PMID]: 27796411
[Au] Autor:Meier B; Maul JT; French LE
[Ad] Address:Klinik für Dermatologie, Universitätsspital Zürich, Gloriastr. 31, 8091, Zürich, Schweiz. barbara.meier2@usz.ch.
[Ti] Title:Pyoderma gangraenosum und Sweet-Syndrom : Hautmanifestationen autoinflammatorischer Erkrankungen. [Pyoderma gangrenosum and Sweet's syndrome : Cutaneous manifestations of autoinflammatory disorders].
[So] Source:Hautarzt;, 2016 Oct 28.
[Is] ISSN:1432-1173
[Cp] Country of publication:Germany
[La] Language:GER
[Ab] Abstract:Pyoderma gangrenosum and Sweet's syndrome are rare diseases that belong to the group of neutrophilic dermatoses and share several common characteristics. Although the two disorders differ clinically from each other, both diseases show pronounced dermal infiltration of neutrophils without evidence of primary vasculitis and respond well to immunosuppressive drugs. In addition, both diseases are often associated with other systemic and hematological disorders. Recent findings show that the neutrophil dermatoses can be considered as cutaneous manifestations of autoinflammation, demonstrating an interesting new aspect in the development of the diseases and additional therapeutic avenues.
[Pt] Publication type:JOURNAL ARTICLE; ENGLISH ABSTRACT
[Em] Entry month:1610
[Cu] Class update date: 161031
[Lr] Last revision date:161031
[St] Status:Publisher

  3 / 36426 MEDLINE  
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[PMID]: 27796264
[Au] Autor:Hasbal NB; Bastürk T; Koç Y; Sahutoglu T; Bayrakdar Caglayan F; Ünsal A
[Ti] Title:Leukocytoclastic vasculitis associated a new anticoagulant: Rivaroxaban.
[So] Source:Turk J Haematol;, 2016 Oct 31.
[Is] ISSN:1308-5263
[Cp] Country of publication:Turkey
[La] Language:ENG
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161031
[Lr] Last revision date:161031
[St] Status:Publisher
[do] DOI:10.4274/tjh.2016.0353

  4 / 36426 MEDLINE  
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[PMID]: 27795441
[Au] Autor:Palinski R; Piñeyro P; Shang P; Yuan F; Guo R; Fang Y; Byers E; Hause BM
[Ad] Address:Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, Kansas, USA.
[Ti] Title:A novel porcine circovirus distantly related to known circoviruses is associated with porcine dermatitis and nephropathy syndrome and reproductive failure.
[So] Source:J Virol;, 2016 Oct 26.
[Is] ISSN:1098-5514
[Cp] Country of publication:United States
[La] Language:ENG
[Ab] Abstract:Porcine circovirus associated disease (PCVAD) is clinically manifested by postweaning multisystemic wasting syndrome (PMWS), respiratory and enteric disease, reproductive failure, and porcine dermatitis and nephropathy syndrome (PDNS). Porcine circovirus type 2 (PCV2) is an essential component of PCVAD although an etiologic role in PDNS is not well established. Here, a novel circovirus, designated porcine circovirus 3 (PCV3), was identified in sows that died acutely with PDNS-like clinical signs. The capsid and replicase proteins of PCV3 share only 37% and 55% identity to PCV2 and bat circoviruses, respectively. Aborted fetuses from sows with PDNS contained high levels of PCV3 (7.57x10(7) genomic copies/ml) and no other viruses were detected by PCR and metagenomic sequencing. Immunohistochemistry (IHC) on sow tissues identified PCV3 antigen in skin, kidney, lung and lymph nodes localized in typical PDNS lesions including necrotizing vasculitis, glomerulonephritis, granulomatous lymphadenitis and bronchinterstitial pneumonia. Further study of archived PDNS tissues, that were negative for PCV2 by IHC, identified 45 of 48 were PCV3 positive by qPCR with 60% of a subset also testing positive for PCV3 by IHC. Analysis by qPCR of 271 porcine respiratory disease diagnostic submissions identified 34 PCV3 positive cases (12.5%), and ELISA detection of anti-PCV3 capsid antibodies in sera found 46 positive samples of 83 tested (55%). These results suggest PCV3 commonly circulates within U.S. swine and may play an etiologic role in reproductive failure and PDNS. Due to the high economic impact of PCV2, this novel circovirus warrants further studies to elucidate its significance and role in PCVAD. IMPORTANCE: While first identified in sporadic cases of postweaning multisystemic wasting syndrome in Canada in the early 1990's, an epidemic of severe systemic disease due to porcine circovirus type 2 (PCV2) spread worldwide in the ensuing decade. Despite being effectively controlled by commercial vaccines, PCV2 remains one of the most economically significant viruses of swine. Here, a novel porcine circovirus (PCV3), which is distantly related to known circoviruses, was identified in sows with porcine dermatitis and nephropathy syndrome (PDNS) and reproductive failure. PCV2, which has previously been associated with these clinical presentations, was not identified. High levels of PCV3 nucleic acid was observed in aborted fetuses by quantitative PCR (qPCR) and PCV3 antigen was localized in histologic lesions typical of PDNS in sows by immunohistochemistry (IHC). PCV3 was also identified in archival PDNS diagnostic cases which previously tested negative for PCV2 using IHC. The emergence of PCV3 warrants further investigation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161031
[Lr] Last revision date:161031
[St] Status:Publisher

  5 / 36426 MEDLINE  
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[PMID]: 27792871
[Au] Autor:Burns JC; Koné-Paut I; Kuijpers T; Shimizu C; Tremoulet A; Arditi M
[Ad] Address:Department of Pediatrics, University of California San Diego and Rady Children's Hospital San Diego, 9500 Gilman Dr. La Jolla, CA, 92093-0641. jcburns@ucsd.edu.
[Ti] Title:Found in Translation: International initiatives pursuing interleukin-1 blockade for treatment of acute Kawasaki Disease.
[So] Source:Arthritis Rheumatol;, 2016 Oct 28.
[Is] ISSN:2326-5205
[Cp] Country of publication:United States
[La] Language:ENG
[Ab] Abstract:The decision to move forward with three clinical trials of IL-1 blockade for treatment of acute Kawasaki disease is a case study in translational science. These trials were born on the one hand from transcriptome studies of host response during the acute disease coupled with animal model investigations of key immune signaling pathways and, on the other hand, out of clinical desperation to intervene in patients with severe inflammation in the setting of acute Kawasaki disease. The convergence of laboratory science and clinical observations led to the clinical trials described here and serves as a model for how such observations can be translated into new therapies. This article is protected by copyright. All rights reserved.
[Pt] Publication type:REVIEW; JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161030
[Lr] Last revision date:161030
[St] Status:Publisher
[do] DOI:10.1002/art.39975

  6 / 36426 MEDLINE  
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[PMID]: 27791948
[Au] Autor:Bitik B; Tufan A; Sahin K; Sucullu Karadag Y; Can Sandikci S; Mercan R; Ak F; Karaaslan Y; Ozturk MA; Goker B; Haznedaroglu S
[Ad] Address:Department of Internal Medicine/Rheumatology, Ankara Education and Research Hospital, Ankara, Turkey. berivanbitik@hotmail.com.
[Ti] Title:The association between the parenchymal neurological involvement and posterior uveitis in Behçet's syndrome.
[So] Source:Clin Exp Rheumatol;34 Suppl 102(6):82-85, 2016 Sep-Oct.
[Is] ISSN:0392-856X
[Cp] Country of publication:Italy
[La] Language:ENG
[Ab] Abstract:OBJECTIVES: Behçet's syndrome (BS) is a systemic vasculitis, which may involve multiple organ systems simultaneously. Clinical findings in BS often fit into well-recognized patterns, such as the association between papulo-pustular skin lesions and arthritis. We have recently observed a distinct pattern, in which a subtype of neuro-Behçet's syndrome (NBS) is often preceded by specific ophthalmic manifestations of the disease process. The purpose of this study is to evaluate the association between the parenchymal subtype of NBS and posterior uveitis (PU). METHODS: We have retrospectively reviewed the clinical records of 295 patients with BS, who met the international classification criteria for BS, diagnosed at two major rheumatology clinics from 2010 to 2014. Patient demographics, ophthalmic examinations, clinical and radiologic patterns of neurological involvement were recorded. Manifestations of BS were classified as PU, NBS, vascular involvement, and arthritis. The association between clinical findings was analysed for statistical significance. RESULTS: Of the 295 patients, 100 had PU and 44 had NBS. 30 patients had parenchymal NBS and 14 had vascular NBS. Patients with PU were significantly more likely to have neurological involvement compared to those without PU (p<0.001; Odds Ratio: 3.924; 95% CI: 1.786-8.621). Rate of posterior uveitis was higher in patients with parenchymal NBS when compared to patients with vascular NBS, vascular BS or arthritis (63.3%, 21.4%, 22% and 4.2% respectively, p<0.001). CONCLUSIONS: Our findings suggest a clinically and statistically significant association between posterior uveitis and parenchymal type of neurologic involvement in BS. The development of posterior uveitis in a patient with previously diagnosed BS should be recognized as a "warning sign" for predisposition to neurologic involvement. These patients should be informed about the possible signs and symptoms of neurological involvement, which can cause very rapid and irreversible damage unless recognized and treated immediately.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161030
[Lr] Last revision date:161030
[St] Status:In-Data-Review

  7 / 36426 MEDLINE  
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[PMID]: 27791393
[Au] Autor:Ostrovrsnik J; Hocevar A; Lestan B; Sodin Semrl S; Lakota K; Tomsic M
[Ad] Address:a Department of Rheumatology , University Medical Centre Ljubljana , Ljubljana , Slovenia.
[Ti] Title:Long-term follow-up on tocilizumab treatment of AA amyloidosis secondary to polyarteritis nodosa.
[So] Source:Amyloid;:1-2, 2016 Oct 28.
[Is] ISSN:1744-2818
[Cp] Country of publication:England
[La] Language:ENG
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161030
[Lr] Last revision date:161030
[St] Status:Publisher

  8 / 36426 MEDLINE  
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[PMID]: 27791307
[Au] Autor:Giménez-Roca C; Iglesias E; Vicente MA; Bou R; Calzada-Hernández J; Prat C; García M; Antón J
[Ad] Address:Pediatric Rheumatology Unit, Department of Pediatrics, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain. cgimenez@hsjdbcn.org.
[Ti] Title:Pediatric cryoglobulinemic vasculitis successfully managed with rituximab.
[So] Source:Dermatol Ther;, 2016 Oct 28.
[Is] ISSN:1529-8019
[Cp] Country of publication:United States
[La] Language:ENG
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161030
[Lr] Last revision date:161030
[St] Status:Publisher
[do] DOI:10.1111/dth.12430

  9 / 36426 MEDLINE  
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[PMID]: 27790283
[Au] Autor:Lee SH; Kim JH; Park S; Won CY; Lee JH; Yi SY; Park HK; Chang SH; Jung H; Lee SS; Koo HK
[Ad] Address:Department of Internal Medicine, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.
[Ti] Title:Pulmonary Leukocytoclastic Vasculitis as an Initial Presentation of Myelodysplastic Syndrome.
[So] Source:Tuberc Respir Dis (Seoul);79(4):302-306, 2016 Oct.
[Is] ISSN:1738-3536
[Cp] Country of publication:Korea (South)
[La] Language:ENG
[Ab] Abstract:Systemic vasculitis involving the lung is a rare manifestation of myelodysplastic syndrome (MDS), and secondary vasculitis is considered to have poor prognosis. A 44-year-old man presented with fever and dyspnea of 1 month duration. A chest radiograph revealed bilateral multiple wedge shaped consolidations. In addition, the results of a percutaneous needle biopsy for non-resolving pneumonia were compatible with pulmonary vasculitis. Bone marrow biopsy was performed due to the persistence of unexplained anemia and the patient was diagnosed with MDS. We reported a case of secondary vasculitis presenting as non-resolving pneumonia, later diagnosed as paraneoplastic syndrome of undiagnosed MDS. The cytopenia and vasculitis improved after a short course of glucocorticoid treatment, and there was no recurrence despite the progression of underlying MDS.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161030
[Lr] Last revision date:161030
[St] Status:In-Data-Review

  10 / 36426 MEDLINE  
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[PMID]: 27790125
[Au] Autor:Yoon CW; Lee E; Yoon BN; Park HK; Rha JH
[Ad] Address:Department of Neurology, Inha University School of Medicine, Incheon, South Korea.
[Ti] Title:A Case of Turner Syndrome with Multiple Embolic Infarcts.
[So] Source:Case Rep Neurol;8(3):199-203, 2016 Sep-Dec.
[Cp] Country of publication:Switzerland
[La] Language:ENG
[Ab] Abstract:Only a few cases of Turner syndrome (TS) with ischemic stroke have been reported. Various arteriopathies of the cerebral arteries, including fibromuscular dysplasia, congenital hypoplasia, moyamoya syndrome, and premature atherosclerosis have been assumed to be the cause of ischemic stroke in TS. There has been no case report of a TS patient presenting with an embolic stroke pattern without any cerebral arteriopathy. A 28-year-old woman with TS was referred to our hospital because of abnormal brain magnetic resonance imaging (MRI) findings. She underwent brain MRI at the referring hospital because she experienced sudden-onset diffuse headache. Diffusion-weighted imaging revealed multiple acute embolic infarcts in different vascular territories. Intracranial and extracranial arterial disease was not detected on cerebral magnetic resonance angiography and carotid sonography. Embolic source workups, including transthoracic and transesophageal echocardiography, Holter monitoring, and transcranial Doppler shunt study, were all negative. Hypercoagulability and vasculitis panels were also negative. Our patient was diagnosed with cryptogenic embolic stroke. This is the first report of a TS patient with an embolic stroke pattern. Our case shows that ischemic stroke in TS could be due to embolism as well as the various cerebral arteriopathies documented in previous reports.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161030
[Lr] Last revision date:161030
[St] Status:In-Data-Review


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