Database : MEDLINE
Search on : Vasculitis [Words]
References found : 33763 [refine]
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[PMID]: 25862016
[Au] Autor:Ciccia F; Rizzo A; Guggino G; Cavazza A; Alessandro R; Maugeri R; Cannizzaro A; Boiardi L; Iacopino DG; Salvarani C; Triolo G
[Ad] Address:Dipartimento Biomedico di Medicina Interna e Specialistica, Sezione di Reumatologia, Università di Palermo....
[Ti] Title:Difference in the expression of IL-9 and IL-17 correlates with different histological pattern of vascular wall injury in giant cell arteritis.
[So] Source:Rheumatology (Oxford);54(9):1596-604, 2015 Sep.
[Is] ISSN:1462-0332
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: GCA is a large- and medium-vessel arteritis characterized by a range of histological patterns of vascular wall injury. The aim of this study was to immunologically characterize the various histological patterns of GCA. METHODS: Thirty-five consecutive patients with biopsy-proven GCA and 15 normal controls were studied. IL-8, IL-9, IL-9R, IL-17, IL-4, TGF-ß and thymic stromal lymphopoietin expression was evaluated by RT-PCR and immunohistochemistry on artery biopsy specimens. Confocal microscopy was used to characterize the phenotypes of IL-9-producing and IL-9R-expressing cells. Five additional patients who had received prednisone when the temporal artery biopsy was performed were also enrolled to evaluate the effect of glucocorticoids on IL-9 and IL-17 expression. RESULTS: IL-17 overexpression was observed mainly in arteries with transmural inflammation and vasa vasorum vasculitis. IL-9 overexpression and Th9 polarization predominated in arteries with transmural inflammation and small-vessel vasculitis. The tissue expression of both IL-9 and IL-17 was correlated with the intensity of the systemic inflammatory response. IL-4, TGF-ß and thymic stromal lymphopoietin, which are involved in the differentiation of Th9 cells, were overexpressed in arteries with transmural inflammation and small-vessel vasculitis. IL-9R was also overexpressed in GCA arteries with transmural inflammation and was accompanied by increased expression of IL-8. CONCLUSION: Herein we provide the first evidence that distinct populations of potentially autoreactive T cells, expressing different cytokines (Th17 vs Th9), characterize patients with particular histological subsets of GCA and may thus contribute to the heterogeneity of tissue lesions observed in these patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1508
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review
[do] DOI:10.1093/rheumatology/kev102

  2 / 33763 MEDLINE  
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[PMID]: 25832613
[Au] Autor:Sangle SR; Vounotrypidis P; Briley A; Nel L; Lutalo PM; Sanchez-Fernandez S; Chaib A; Salas-Manzanedo V; Shennan A; Khamashta MA; D'Cruz DP
[Ad] Address:The Lupus Research Unit, The Rayne Institute, St Thomas' Hospital....
[Ti] Title:Pregnancy outcome in patients with systemic vasculitis: a single-centre matched case-control study.
[So] Source:Rheumatology (Oxford);54(9):1582-6, 2015 Sep.
[Is] ISSN:1462-0332
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To study the outcome of pregnancy in patients with systemic vasculitis (SV) compared with age-, BMI- and ethnicity-matched healthy pregnant controls. METHODS: Fifty-one pregnancies in 29 SV patients were retrospectively studied. There were nine patients with granulomatosis with polyangiitis (GPA), three with eosinophilic GPA, seven with Takayasu's arteritis, two with ANCA-positive vasculitis with renal involvement, two with Behçet's disease, three with urticarial vasculitis, one with primary cerebral vasculitis, one with relapsing polychondritis and one with IgA vasculitis. BVAS and the vasculitis damage index were evaluated retrospectively. Sixty-two healthy women with 156 pregnancies matched in a 2:1 ratio for age, BMI and ethnicity formed the control group. RESULTS: Median gestational age at delivery was lower in the SV group: 36 weeks and 2 days (34-42) vs controls 40 (37-42) weeks (P < 0.03). Median birth weight in the SV group was 3.0 kg (2.0-5.2), whereas that of the controls was 3.5 (2.28-4.32) kg (P = 0.004). The median customized birth weight centile was 38.6 in the SV group and 37.2 in the control group. In the SV group, 9 patients had 13 miscarriages, 3 had pre-eclampsia, and 2 had an intrauterine death. In the control group, 20 patients had 27 miscarriages, 1 had pre-eclamptic toxaemia, and 1 had an antepartum haemorrhage. Eight patients with SV flared during pregnancy and 11 flared after delivery. CONCLUSION: Patients with SV had a lower median gestational age, but customized birth weights were similar to those of healthy women. Women with SV may flare during pregnancy and the post-partum period and may experience significant pregnancy morbidity.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1508
[Js] Journal subset:AIM; IM
[St] Status:In-Data-Review
[do] DOI:10.1093/rheumatology/kev018

  3 / 33763 MEDLINE  
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[PMID]: 26275272
[Au] Autor:Krishnamurthy K; Mohapatra S; Mishra TK; Jha N
[Ad] Address:Department of Biochemistry, Maulana Azad Medical College, Bahadur Shah Zafar Marg, New Delhi, India.
[Ti] Title:Early onset mixed cryoglobulinemia in hepatitis C.
[So] Source:Indian J Pathol Microbiol;58(3):381-3, 2015 Jul-Sep.
[Is] ISSN:0974-5130
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:Cryoglobulinemia is one of the most common forms of extrahepatic manifestation of chronic hepatitis infection. The phenomenon is generally seen after several years of chronicity predominantly in the female population resulting in arthralgias, purpuras, and other symptoms, due to vasculitis. Here we present a case of incomplete mixed cryoglobulinemia Type III (as per Brouet's classification) in a young boy aged 13 years who presented with an unusual symptom of pruritus. Diagnosis was confirmed by cryoprecipitation test followed by immunofixation. We aim to highlight the difficulty in diagnosis of this rare case/presentation, important investigation pitfalls and how to avoid them.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1508
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.4103/0377-4929.162914

  4 / 33763 MEDLINE  
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[PMID]: 26265851
[Au] Autor:Vichare N; Bhargava N; Brijmohan; Chaturvedi PK
[Ad] Address:Classified Specialist (Ophthalmology), Command Hospital (Southern Command), Pune 411040, India....
[Ti] Title:A rare case of idiopathic retinal vasculitis, aneurysms and neuroretinitis (IRVAN) syndrome.
[So] Source:Med J Armed Forces India;71(Suppl 1):S257-60, 2015 Jul.
[Is] ISSN:0377-1237
[Cp] Country of publication:India
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1508
[Cu] Class update date: 150814
[Lr] Last revision date:150814
[Da] Date of entry for processing:150812
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1016/j.mjafi.2014.07.011

  5 / 33763 MEDLINE  
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[PMID]: 25934841
[Au] Autor:Bunch DO; Mendoza CE; Aybar LT; Kotzen ES; Colby KR; Hu Y; Hogan SL; Poulton CJ; Schmitz JL; Falk RJ; Nachman PH; Pendergraft WF; McGregor JG
[Ad] Address:Department of Medicine, University of North Carolina (UNC) Kidney Center, Chapel Hill, North Carolina, USA....
[Ti] Title:Gleaning relapse risk from B cell phenotype: decreased CD5+ B cells portend a shorter time to relapse after B cell depletion in patients with ANCA-associated vasculitis.
[So] Source:Ann Rheum Dis;74(9):1784-6, 2015 Sep.
[Is] ISSN:1468-2060
[Cp] Country of publication:England
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1508
[Cu] Class update date: 150814
[Lr] Last revision date:150814
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1136/annrheumdis-2014-206756

  6 / 33763 MEDLINE  
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[PMID]: 25480731
[Au] Autor:Batu ED; Ozen S
[Ad] Address:Division of Paediatric Rheumatology, Department of Paediatrics, Hacettepe University Faculty of Medicine, Ankara, 06100, Turkey.
[Ti] Title:Vasculitis: do we know more to classify better?
[So] Source:Pediatr Nephrol;30(9):1425-32, 2015 Sep.
[Is] ISSN:1432-198X
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:The systemic vasculitides are a heterogeneous group of disorders characterized by the inflammation of blood vessels. The development and implementation of advanced diagnostic tests and genetic studies have resulted in substantial improvement in our understanding of vasculitis pathogenesis, resulting in the revision of the nomenclature and classification for vasculitis. Multicenter, collaborative studies are currently underway to develop improved diagnostic criteria. In this review, the major nomenclature and classification systems for vasculitides are summarized, with special emphasis on those emerging from the recent 2012 Chapel Hill Consensus Conference (CHCC).
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1508
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s00467-014-3015-0

  7 / 33763 MEDLINE  
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[PMID]: 25876643
[Au] Autor:Sotoodian B; Robert J; Mahmood MN; Yacyshyn E
[Ad] Address:Division of Dermatology, Department of Medicine, University of Alberta, Edmonton, AB, Canada bahman.sotoodian@gmail.com....
[Ti] Title:IgA Cutaneous Purpura Post-Renal Transplantation in a Patient With Long-Standing IgA Nephropathy: Case Report and Literature Review.
[So] Source:J Cutan Med Surg;19(5):498-503, 2015 Sep.
[Is] ISSN:1203-4754
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: IgA vasculitis is a small-vessel vasculitis caused by deposition of IgA antibodies in tissues. IgA nephropathy and IgAV have long been considered related conditions. OBJECTIVE: To assess the prevalence and implications of new-onset Henoch-Schönlein purpura (HSP) after renal transplant in patients with underlying IgA nephropathy. METHODS: The PubMed database was searched for keywords such as IgAV, IgA vasculitis, Henoch-Schönlein purpura, HSP, IgA nephropathy, and renal transplant. RESULTS: Two cases of new-onset IgA vasculitis post-renal transplant after stopping the prednisone or receiving seasonal influenza vaccine have been reported. We report the case of new-onset IgA cutaneous vasculitis in a renal transplant patient with IgA nephropathy after reduction in his prednisone dosage. CONCLUSION: The new development of cutaneous IgA vasculitis is unusual in renal transplant patients with IgA nephropathy. Despite these patients' being immunosuppressed, the presence of IgA vasculitis could signal the recurrence of IgA nephropathy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1508
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1177/1203475415582135

  8 / 33763 MEDLINE  
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[PMID]: 25963026
[Au] Autor:Wang H; Wang C; Zhao MH; Chen M
[Ad] Address:Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China....
[Ti] Title:Neutrophil extracellular traps can activate alternative complement pathways.
[So] Source:Clin Exp Immunol;181(3):518-27, 2015 Sep.
[Is] ISSN:1365-2249
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The interaction between neutrophils and activation of alternative complement pathway plays a pivotal role in the pathogenesis of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). ANCAs activate primed neutrophils to release neutrophil extracellular traps (NETs), which have recently gathered increasing attention in the development of AAV. The relationship between NETs and alternative complement pathway has not been elucidated. The current study aimed to investigate the relationship between NETs and alternative complement pathway. Detection of components of alternative complement pathway on NETs in vitro was assessed by immunostain and confocal microscopy. Complement deposition on NETs were detected after incubation with magnesium salt ethyleneglycol tetraacetic acid (Mg-EGTA)-treated human serum. After incubation of serum with supernatants enriched in ANCA-induced NETs, levels of complement components in supernatants were measured by enzyme-linked immunosorbent assay (ELISA). Complement factor B (Bb) and properdin deposited on NETs in vitro. The deposition of C3b and C5b-9 on NETs incubated with heat-inactivated normal human serum (Hi-NHS) or EGTA-treated Hi-NHS (Mg-EGTA-Hi-NHS) were significantly less than that on NETs incubated with NHS or EGTA-treated NHS (Mg-EGTA-NHS). NETs induced by ANCA could activate the alternative complement cascade in the serum. In the presence of EGTA, C3a, C5a and SC5b-9 concentration decreased from 800·42 ± 244·81 ng/ml, 7·68 ± 1·50 ng/ml, 382·15 ± 159·75 ng/ml in the supernatants enriched in ANCA induced NETs to 479·07 ± 156·2 ng/ml, 4·86 ± 1·26 ng/ml, 212·65 ± 44·40 ng/ml in the supernatants of DNase I-degraded NETs (P < 0·001, P = 0·008, P < 0·001, respectively). NETs could activate the alternative complement pathway, and might thus participate in the pathogenesis of AAV.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1508
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/cei.12654

  9 / 33763 MEDLINE  
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[PMID]: 25925589
[Au] Autor:Jois R; Gupta A; Krishnamurthy S
[Ad] Address:Rheumatology, Fortis Hospitals, Bangalore, India.
[Ti] Title:Ureteric vasculitis, an unusual presentation of polyarteritis nodosa: a case report.
[So] Source:Int J Rheum Dis;18(5):577-9, 2015 Jun.
[Is] ISSN:1756-185X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:A 22 year old female presented with vasculitic skin rash. She was incidentally found to be hypertensive and had proteinuria. Skin biopsy showed leuco-cytoclastic vasculitis. On Imaging, there was left hydronephrosis, hydroureter with bilateral multiple foci of ureteric stenosis and micro-aneurysms in relation to interlobar arteries of kidney. A diagnosis of classical Polyarteritis Nodosa (cPAN) with multi-level ureteric stenosis was made. She was treated with Glucocorticoids, Cyclophosphamide, following which Azathioprine was given.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1506
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1111/1756-185X.12547

  10 / 33763 MEDLINE  
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[PMID]: 26033562
[Au] Autor:Pendergraft WF; Nachman PH
[Ad] Address:University of North Carolina (UNC), kidney center, division of nephrology, department of medicine, Chapel Hill, NC 27599-7155, United States; Broad Institute of Harvard and MIT, Cambridge, MA, United States.
[Ti] Title:Recent pathogenetic advances in ANCA-associated vasculitis.
[So] Source:Presse Med;44(6 Pt 2):e223-9, 2015 Jun.
[Is] ISSN:0755-4982
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:Since the discovery of anti-neutrophil cytoplasmic autoantibodies (ANCA), great strides have been made in elucidating the etiology and pathogenesis of disease. In this article, we review recent published key breakthroughs in understanding the pathogenesis of ANCA vasculitis, including some that may lead to novel therapeutics. These breakthroughs have occurred in multiple areas of investigation. A European genome-wide association study (GWAS) revealed the importance of the genetic contribution of proteinase 3 (PR3) and its endogenous inhibitor, alpha (1)-antitrypsin as well as HLA risk. Epigenetic modification of autoantigen genes appears to contribute to perpetuation of disease and possibly relapse risk. Autoantigen excision, a novel method to detect autoantibody epitopes using mass spectrometry, not only revealed pathogenic epitopes in myeloperoxidase (MPO)-ANCA vasculitis and identified unique MPO-ANCA responsible for the majority of ANCA-negative small vessel vasculitis, but has vast applicability to other autoantibody-mediated diseases. An explosion of biomarker studies has revealed circulating cytokines and alternative complement pathway products that may predict active disease. Interestingly, alternative complement pathway blockade in the murine model of disease is protective and a clinical trial in humans using an oral alternative complement pathway inhibitor is underway. Increasing clarity of the role of B and T cells in disease pathogenesis is ongoing. B cell depleting agents have shown great utility in remission induction and maintenance, and monitoring specific B cell subsets during the disease course may have predictive power for remission maintenance. Despite these substantial advances, more research is needed including, but not limited to, validation of existing discoveries. As additional novel discoveries emerge, so will novel therapies, and it is with great hope that these collective insights will ultimately lead to prevention and cure.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1506
[Js] Journal subset:IM
[St] Status:In-Process


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