Database : MEDLINE
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[PMID]: 25041449
[Au] Autor:Smith JH; Swanson JW
[Ad] Address:Kentucky Neuroscience Institute, University of Kentucky, Lexington, KY, USA.
[Ti] Title:Giant cell arteritis.
[So] Source:Headache;54(8):1273-89, 2014 Sep.
[Is] ISSN:1526-4610
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Giant cell arteritis (GCA) is a medium and large-vessel vasculitis, which is an important cause of secondary headache in older adults. While GCA has a classic presentation occurring after the age of 50, atypical presentations (eg, fever of unknown origin, cough, low or normal erythrocyte sedimentation rate) may lead to a delay in diagnosis. The topography of vascular involvement has implications for disease-related complications, which can result in neurologic disease at multiple levels of the nervous system. The most feared complication, vision loss, fortunately becomes uncommon after initiation of corticosteroids. Corticosteroid treatment should not be withheld while waiting the results of a temporal artery biopsy (TAB), which remains the gold standard for GCA diagnosis. Newer diagnostic modalities, including ultrasound, magnetic resonance imaging, and positron emission tomography can play an important role in directing treatment in cases with negative TAB. After successful control of the disorder, patients should be gradually tapered off corticosteroids, with careful monitoring using both clinical and laboratory parameters to assess for relapse. Corticosteroid-related treatment complications are not uncommon in GCA. There is mixed evidence for use of adjunct corticosteroid-sparing agents (eg, methotrexate), although these should be initiated in the setting of corticosteroid-related morbidity and/or cases with frequent relapse.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/head.12425

  2 / 32190 MEDLINE  
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[PMID]: 24827146
[Au] Autor:Rotstein DL; Tyndel FJ; Tang-Wai DF
[Ad] Address:Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
[Ti] Title:A Case Report of Cavernous Sinus Syndrome in a Patient With Takayasu's Arteritis.
[So] Source:Headache;54(8):1371-5, 2014 Sep.
[Is] ISSN:1526-4610
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Neurologists must entertain a broad differential diagnosis when considering a patient with cavernous sinus syndrome, including neoplasm, trauma, vascular causes, inflammatory processes, and infections. We report the case of a 37-year-old woman initially diagnosed with cavernous sinus syndrome, where subsequent investigations revealed findings of Takayasu's arteritis, a large vessel vasculitis. The patient also tested positive for perinuclear antineutrophil cytoplasmic antibodies, suggesting the possibility of a vasculitic spectrum disorder although no clinical features of Wegener's granulomatosis were present. Criteria for Takayasu's arteritis and its protean neurologic manifestations are reviewed. This case highlights the spectrum of vasculitic conditions that may be associated with cavernous sinus inflammation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/head.12390

  3 / 32190 MEDLINE  
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[PMID]: 25193910
[Au] Autor:Dhaou BB; Boussema F; Aydi Z; Ketari S; Baili L; Moussa FB; Rokbani L
[Ad] Address:Internal Medicine Department, Habib Thameur Hospital, Tunis, Tunisia.
[Ti] Title:Renal paraneoplastic vasculitis complicating lung adenocarcinoma.
[So] Source:Saudi J Kidney Dis Transpl;25(5):1065-7, 2014 Sep-Oct.
[Is] ISSN:1319-2442
[Cp] Country of publication:Saudi Arabia
[La] Language:eng
[Ab] Abstract:Renal paraneoplastic vasculitis (RNPV) is rare. It can be revealed by glomerulonephritis, microaneurysms or renal failure. RPNV may precede the onset of the primary tumor, and treatment and prognosis depend on the etiology (primary tumor). A 54-year-old man who had a primary lung adenocarcinoma was admitted for nephrotic syndrome. The investigations revealed RNPV. The patient was treated with corticosteroids at high dose and cyclophosphamide with improvement of the renal condition; however, the patient died from worsening of his pulmonary neoplasia.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review

  4 / 32190 MEDLINE  
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[PMID]: 25177783
[Ti] Title:[Idiopathic arrhythmias: possibilities of complex nosological diagnosis, and differentiated treatment].
[So] Source:Kardiologiia;54(4):28-38, 2014.
[Is] ISSN:0022-9040
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:AIM: of the study was to elucidate nosological nature of "idiopathic" arrhythmias by means of complex clinical-morphological examination and to assess efficacy of differentiated (including etiotropic and pathogenetic) treatment. MATERIAL AND METHODS: We examined 190 patients (117 women, mean age 45.33 ± 14.84 years) with "idiopathic" arrhythmias: atrial fibrillation (38.9%) (AF,) and flutter (11.1%), supraventricular (44.7%) and ventricular (55.3%) extrasystoles (SVE and VE), bouts of ventricular tachycardia (15.8%), atrioventricular block (22,6%) et al. Mean number of antiarrhythmic drugs per patient was 3 (from 1 to 8). Examination included Holter ECG monitoring, echocardiography, determination of anticardiac antibodies (97.4%) and markers of cardiotropic viruses (87.4%), treadmill test (26.3%), transesophageal cardiac pacing (12.1%), electrophysiological investigation (10%), multispiral computed tomography (22.1%), magnetic resonance tomography (21.6%), scintigraphy (27.4%), coronary angiography (10.0%), endomyocardial biopsy (EMB) (10.0%), DNA diagnostics (8.9%). RESULTS: EMB revealed immune-inflammatory (myo/endocarditis, systemic/myocardial vasculitis) or genetic pathology in 78.9 and 21.1% of cases, respectively. Level of anticardiac antibodies (including specific antinuclear factor) most closely correlated with EMB findings. On the basis of comparison of EMB data with data of complex examination we created algorithm of nosological diagnostics in "idiopathic" arrhythmias. According to nosology all patients were distributed in the following way: 1) chronic infectious-immune myocarditis (n=144, 75.7%), morphologically verified in 14, viral in 27 patients; 2) genetic cardiomyopathy (n=15, 7.9%), morphologically verified in 4, virus positive in 1 (arrhythmogenic right ventricular dysplasia, non-compaction myocardium, Fabri disease, Brugada syndrome, undetermined); in 4 patients mutations in plakophilin 2, desmoglein, desmin, -galactosidase A genes were found; 3) combination of genetic diseases with myocarditis (n=18; 9.5%) including viral (n=3); 4) isolated myocardiodystrophy (tonsillogenic< dyshormonal, n=3, 1.6%); 5) proper idiopathic arrhythmias (n=10, 5.3%). Therapy of myocarditis included antiviral (43.2%) and immunosuppressive (76.3%) drugs. Cardiotropic and antiarrhythmic therapy was also administered. Only in patients with myocarditis it was possible to withdraw effective antiarrhythmic (16.7%) and to improve effect of previously ineffective drugs. Surgical treatment (implantation of pacemaker or cardioverter-defibrillator, radiofrequency ablation) was more frequently used in patients with genetic (39.4%) and idiopathic arrhythmias (53.8%) than in patients with myocarditis (16.0%). CONCLUSION: Etiology of idiopathic arrhythmias can be established in most cases. Their main causes are immune-inflammatory diseases, genetic cardiomyopathies and their combination. Therapy of myocarditis improves antiarrhythmic activity of treatment, in some patients allows to withdraw antiarrhythmic drugs, decrease requirements in surgical treatment and to optimally prepare patients to radiofrequency ablation.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Process

  5 / 32190 MEDLINE  
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[PMID]: 24911939
[Au] Autor:Dotan M; Nahum E; Weigl D; Bilavsky E
[Ad] Address:Departments of aPediatrics C bPediatric Intensive Care cPediatric Orthopedic Unit, Schneider Children's Medical Center of Israel, Petach Tikva dSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
[Ti] Title:Compartment syndrome because of acute hemorrhagic edema of infancy: a case report and literature review.
[So] Source:J Pediatr Orthop B;23(5):419-21, 2014 Sep.
[Is] ISSN:1473-5865
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:UNLABELLED: Acute hemorrhagic edema of infancy (AHEI) is a benign, self-limiting vasculitis that usually resolves completely without any sequelae or a need for active therapy. To our knowledge, compartment syndrome because of AHEI has not been reported. Chart data for a single case were reviewed and reported in a retrospective study. A 19-month-old male presented with petechial rash and swelling of the left lower leg. AHEI was diagnosed clinically and confirmed by skin biopsy. On the basis of the clinical appearance, compartment syndrome of the foot was suspected. Measurements of compartmental pressures in the foot were well above the commonly cited ranges and a fasciotomy was performed. Following the operation, there was a marked clinical improvement in the limb perfusion. The child was discharged on the 20th day with marked clinical improvement; both active and passive leg movements were intact. We suggest that pediatric orthopedic surgeons should be familiar with this entity and its rare complication. LEVEL OF EVIDENCE: V - case report.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1097/BPB.0000000000000060

  6 / 32190 MEDLINE  
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[PMID]: 24709271
[Au] Autor:Groh M; Masciocco G; Kirchner E; Kristen A; Pellegrini C; Varnous S; Bortman G; Rosenberg M; Brucato A; Waterworth P; Bonacina E; Facchetti F; Calabrese L; Gregorini G; Scali JJ; Starling R; Frigerio M; D'Armini AM; Guillevin L
[Ad] Address:Department of Internal Medicine, National Referral Center for Rare Autoimmune and Systemic Diseases, INSERM U1016, Hôpital Cochin, APHP, Université Paris Descartes, Paris, France. Electronic address: matthieugroh@hotmail.com....
[Ti] Title:Heart transplantation in patients with eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome).
[So] Source:J Heart Lung Transplant;33(8):842-50, 2014 Aug.
[Is] ISSN:1557-3117
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Heart involvement is the leading cause of death of patients with eosinophilic granulomatosis with polyangiitis (EGPA; formerly Churg-Strauss syndrome) and is more frequent in anti-neutrophil cytoplasm antibody (ANCA)-negative patients. Post-transplant outcome has only been reported once. METHODS: We conducted a retrospective international multicenter study. Patients satisfying the criteria of the American College of Rheumatology and/or revised Chapel Hill Consensus Conference Nomenclature were identified by collaborating vasculitis and transplant specialists, and the help of the Churg-Strauss Syndrome Association. RESULTS: Nine ANCA(-) patients who received transplants between October 1987 and December 2009 were identified. The vasculitis and cardiomyopathy diagnoses were concomitant for 5 patients and separated by 12 to 288 months for the remaining 4 patients. Despite ongoing immunosuppression, histologic examination of 7 (78%) patients' explanted hearts showed histologic patterns suggestive of active vasculitis. The overall 5-year survival rate was low (57%), but rose to 80% when considering only the 6 patients transplanted during the last decade. After survival lasting 3 to 60 months, 4 (44%) patients died sudden deaths. CONCLUSIONS: The search for EGPA-related cardiomyopathy is mandatory early in the course of this type of vasculitis. Indeed, prompt treatment with corticosteroids and cyclophosphamide may achieve restore cardiac function. Most patients in this series were undertreated. For patients with refractory EGPA, heart transplantation should be performed, which carries a fair prognosis. No optimal immunosuppressive strategy has yet been identified.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Process

  7 / 32190 MEDLINE  
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[PMID]: 24491664
[Au] Autor:Philip S; Lee WC; Wu MH; Mammen CK; Lue HC
[Ad] Address:Department of Pediatric Cardiology, St. Gregorios Cardio-Vascular Center, Parumala, Kerala, India; Department of Cardiothoracic Surgery, Fontier Lifeline Hospital, Dr. K. M. Cherian Heart Foundation, Ambattur, Chennai, India; Division of Biotechnology, Cardiovascular Research Center, Animal Technolo...
[Ti] Title:Histopathological evaluation of horse serum-induced immune complex vasculitis in swine: implication to coronary artery lesions in Kawasaki disease.
[So] Source:Pediatr Neonatol;55(4):297-305, 2014 Aug.
[Is] ISSN:1875-9572
[Cp] Country of publication:Singapore
[La] Language:eng
[Ab] Abstract:BACKGROUND: Immune complex (IC) vasculitis can be experimentally induced in animal models by intravenous injection of horse serum (HS), and the findings of HS-induced IC vasculitis in swine were very similar to that of Kawasaki disease (KD). The IC mechanism may be involved in the pathogenesis of vasculitis in KD. Here, we studied the two-dimensional (2D) echocardiographic and histopathological findings of acute, subacute, and healing phases of vasculitis induced by two different types of HS, and the reproducibility of IC vasculitis in swine. METHODS AND RESULTS: Our study group consisted of 24 pure-bred landrace male piglets of 1.5-3 months of age. They were divided into three HS groups (n = 17), namely, Group A (n = 8) receiving gamma globulin-free HS, and Group B (n = 6) receiving donor herd HS, three doses at 5-day intervals, and Group C (n = 3) that received only one dose of donor herd HS on Day 1, and the saline group (n = 7) that received three doses of intravenous normal saline (NS) at 5-day intervals. The 2D echocardiography was performed every 3-4 days, and all piglets were killed for histopathological studies at different dates from Days 2 to Day 60. All the HS groups developed rashes and demonstrated significant dilation (54-150%) of coronary arteries in Groups A and B; when compared (p < 0.02) with 9-53% dilation in Group C and the saline group. Histopathological changes of test groups were asymmetric coronary vasculitis in various stages, whereas none of the piglets in the control group developed vasculitis. No significant difference in the echocardiographic and histopathological findings was observed among the piglets that received two types of HS. CONCLUSION: HS can induce IC vasculitis in swine. The rashes and 2D echocardiographic and histopathological studies of the acute to healing phases showed close similarities with KD, and it is concluded that swine may serve as a unique experimental model for IC vasculitis and for various therapeutic trials.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Process

  8 / 32190 MEDLINE  
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[PMID]: 25036568
[Au] Autor:González LA; Muñoz C; Restrepo M; Vanegas AL; Vásquez G
[Ad] Address:From the *Sección de Reumatología, Universidad de Antioquia, Hospital Universitario San Vicente Fundación; †Hospital Pablo Tobón Uribe; and ‡Sección de Inmunogenética, Universidad de Antioquia, Medellín, Colombia.
[Ti] Title:Tuberculosis infection causing intestinal perforations in 2 patients with systemic lupus erythematosus.
[So] Source:J Clin Rheumatol;20(5):287-90, 2014 Aug.
[Is] ISSN:1536-7355
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Patients with systemic lupus erythematosus (SLE) have a higher incidence rate of tuberculosis and a more frequent extrapulmonary involvement than the general population. We present 2 SLE patients who developed gastrointestinal tuberculosis complicated with intestinal perforation, a rare but serious complication that could be confused with lupus-associated intestinal vasculitis. Opportunistic infections such as tuberculosis must be suspected in SLE patients with abdominal symptoms on immunosuppressive therapy because its early recognition could prevent catastrophic complications such as intestinal perforation and subsequent peritonitis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1097/RHU.0000000000000129

  9 / 32190 MEDLINE  
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[PMID]: 24833304
[Au] Autor:Cremin K; Leo P; Harris JE; De Smit E; Bradbury L; McKelvie P; Hill CL; Brown MA; Hewitt AW
[Ad] Address:The University of Queensland Diamantina Institute, Translational Research Institute, The University of Queensland, Brisbane, Queensland, Australia....
[Ti] Title:Utility of temporal artery biopsy samples for genome-wide analysis of giant cell arteritis.
[So] Source:Genes Immun;15(5):338-40, 2014 Jul-Aug.
[Is] ISSN:1476-5470
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Giant Cell Arteritis (GCA) is the most common vasculitis affecting the elderly. Archived formalin-fixed paraffin-embedded (FFPE) temporal artery biopsy (TAB) specimens potentially represent a valuable resource for large-scale genetic analysis of this disease. FFPE TAB samples were obtained from 12 patients with GCA. Extracted TAB DNA was assessed by real time PCR before restoration using the Illumina HD FFPE Restore Kit. Paired FFPE-blood samples were genotyped on the Illumina OmniExpress FFPE microarray. The FFPE samples that passed stringent quality control measures had a mean genotyping success of >97%. When compared with their matching peripheral blood DNA, the mean discordant heterozygote and homozygote single nucleotide polymorphisms calls were 0.0028 and 0.0003, respectively, which is within the accepted tolerance of reproducibility. This work demonstrates that it is possible to successfully obtain high-quality microarray-based genotypes FFPE TAB samples and that this data is similar to that obtained from peripheral blood.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1038/gene.2014.19

  10 / 32190 MEDLINE  
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[PMID]: 24507578
[Au] Autor:Mumoli L; Gambardella A; Labate A; Succurro E; De Sarro G; Arturi F; Gallelli L
[Ti] Title:Rosacea-like facial rash related to metformin administration in a young woman.
[So] Source:BMC Pharmacol Toxicol;15:3, 2014.
[Is] ISSN:2050-6511
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Since the skin represents a common site of adverse drug reactions, few data are reported at this time regarding the development of skin rash during the treatment with antidiabetic drugs. CASE PRESENTATION: We report a 29-year old woman that developed a facial skin rash during the treatment with metformin. Clinical and laboratory findings excluded the presence of systemic diseases, but several diagnosis and many drugs were administered without clinical improvement. The self-dismission of metformin induced an improvement of symptoms, while the re-challenge documented an impairments of skin rash. The Naranjo probability scale suggested a probable association between metformin and skin rash and metformin was definitively dismissed. CONCLUSION: We report for the first time a non vasculitis facial skin manifestation related to metformin in a young woman. However, this case may emphasizes the need to consider the ADRs as a differential diagnosis in order to reduce medical errors and the related medical costs.
[Mh] MeSH terms primary: Drug Eruptions/etiology
Exanthema/chemically induced
Hypoglycemic Agents/adverse effects
Metformin/adverse effects
[Mh] MeSH terms secundary: Adult
Female
Humans
Insulin Resistance
Rosacea
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Hypoglycemic Agents); 9100L32L2N (Metformin)
[Em] Entry month:1409
[Js] Journal subset:IM
[Da] Date of entry for processing:140213
[St] Status:MEDLINE
[do] DOI:10.1186/2050-6511-15-3


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