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[PMID]: 23671751 [Au] Autor: Jensen-Kondering U; Böhm R [Ad] Address: Ulf Jensen-Kondering, Institute of Neuroradiology, University of Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany. [Ti] Title: Asymmetrically hypointense veins on T2*w imaging and susceptibility-weighted imaging in ischemic stroke. [So] Source: World J Radiol;5(4):156-65, 2013 Apr 28. [Is] ISSN: 1949-8470 [Cp] Country of publication: China [La] Language: eng [Ab] Abstract: AIM: To review the literature on the assessment of venous vessels to estimate the penumbra on T2*w imaging and susceptibility-weighted imaging (SWI). METHODS: Literature that reported on the assessment of penumbra by T2*w imaging or SWI and used a validation method was included. PubMed and relevant stroke and magnetic resonance imaging (MRI) related conference abstracts were searched. Abstracts that had overlapping content with full text articles were excluded. The retrieved literature was scanned for further relevant references. Only clinical literature published in English was considered, patients with Moya-Moya syndrome were disregarded. Data is given as cumulative absolute and relative values, ranges are given where appropriate. RESULTS: Forty-three publications including 1145 patients could be identified. T2*w imaging was used in 16 publications (627 patients), SWI in 26 publications (453 patients). Only one publication used both (65 patients). The cumulative presence of hypointense vessel sign was 54% (range 32%-100%) for T2* (668 patients) and 81% (range 34%-100%) for SWI (334 patients). There was rare mentioning of interrater agreement (6 publications, 210 patients) and reliability (1 publication, 20 patients) but the numbers reported ranged from good to excellent. In most publications (n = 22) perfusion MRI was used as a validation method (617 patients). More patients were scanned in the subacute than in the acute phase (596 patients vs 320 patients). Clinical outcome was reported in 13 publications (521 patients) but was not consistent. CONCLUSION: The low presence of vessels signs on T2*w imaging makes SWI much more promising. More research is needed to obtain formal validation and quantification. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1305 [St] Status: In-Data-Review [do] DOI: 10.4329/wjr.v5.i4.156

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[PMID]: 23671747 [Au] Autor: Le O [Ad] Address: Ott Le, Diagnostic Imaging, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, United States. [Ti] Title: Patterns of peritoneal spread of tumor in the abdomen and pelvis. [So] Source: World J Radiol;5(3):106-12, 2013 Mar 28. [Is] ISSN: 1949-8470 [Cp] Country of publication: China [La] Language: eng [Ab] Abstract: The spread of tumor in the peritoneum can be understood, although it is a complex organ. A study of its embryology, anatomy and function is of clear benefit. It is formed from a network of folds, reflections, and potential spaces produced by the visceral and parietal peritoneum. These folds and reflections begin as a dorsal and ventral mesentery, supporting the primitive gut in early embryologic development. The dorsal mesentery connects the stomach and other organs to the posterior abdominal wall, while the ventral mesentery connects the stomach to the ventral abdominal wall. As the embryo develops, there is further organ growth, elongation, cavitation and rotation. The dorsal and ventral mesentery also develops along with the viscera, forming ligaments, mesenteries, omenta and potential spaces from the resulting reflections and folds. These ligaments, mesenteries, and omenta, support and nurture the organs of the peritoneum, providing a highway for arteries, veins, nerves and lymphatics. The potential spaces created from these folds and reflections of the visceral and parietal peritoneum are also important to realize. For example, the transverse mesocolon divides the peritoneal cavity into a supramesocolic and inframesocolic space in the abdomen and paravesicular spaces within the pelvis. The falciform ligament is well known in the supramesocolic space, dividing it further into a left and right compartment. Knowledge of the peritoneal vascular anatomy is beneficial in locating the spaces and ligaments about the peritoneum. For example, identifying the left gastric artery or vein will lead to the gastrohepatic ligament, which is part of the supramesocolic space. Besides serving a life sustaining role, the multiple compartments, ligaments, mesenteries and omenta within the peritoneum can also facilitate the spread of disease. Tumors can spread directly from one organ to another, seed metastatic deposits in the peritoneal cavity, and travel through the lymphatic or hematogenous route to invade other organs in the peritoneum. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1305 [St] Status: In-Data-Review [do] DOI: 10.4329/wjr.v5.i3.106

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[PMID]: 22078990 [Au] Autor: Krul SP; Driessen AH; Zwinderman AH; van Boven WJ; Wilde AA; de Bakker JM; de Groot JR [Ad] Address: Heart Failure Research Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. [Ti] Title: Navigating the mini-maze: Systematic review of the first results and progress of minimally-invasive surgery in the treatment of atrial fibrillation. [So] Source: Int J Cardiol;166(1):132-40, 2013 Jun 5. [Is] ISSN: 1874-1754 [Cp] Country of publication: Netherlands [La] Language: eng [Ab] Abstract: BACKGROUND: In this paper we present a systematic literature overview and analysis of the first results and progress made with minimally-invasive surgery using RF energy in the treatment of AF. The minimally-invasive treatment for atrial fibrillation (AF) tries to combine the success rate of surgical treatment with a less invasive approach to surgery. It has the additional potential advantage of ganglion plexus (GP) ablation and left atrial appendage exclusion. Furthermore, additional left atrial ablation lines (ALAL) can be created in non-paroxysmal AF patients. METHODS: For the search query multiple databases were used. Exclusion and inclusion criteria were applied to select the publications to be screened. All remaining articles were critically appraised and only relevant and valid articles were included in our results. RESULTS: Twenty-three studies were included. In 15 studies GPs around the pulmonary veins were ablated. In four studies ALAL were performed. Single procedure success rate was 69% (95% CI, range 58%-78%) without antiarrhythmic drugs (AAD) and 79% (95% CI, range 71%-85%) with AAD at one year follow-up. Mortality was 0.4%, and various complications were reported (3.2% surgical, 3.2% post-surgical, 2.6% cardiac, 2.1% pulmonary, 1.7% other). CONCLUSIONS: Twenty-three studies of minimally-invasive surgery for AF have been reviewed with success rates between that of the standard maze procedure and catheter ablation. These first combined results show promise; however, minimally-invasive surgery is still evolving, for instance by the recent inclusion of electrophysiological endpoints. Furthermore, the type of ALAL and the additional value of GP ablation have to be elucidated. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1305 [Js] Journal subset: IM [St] Status: In-Data-Review

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[PMID]: 23241762 [Au] Autor: Cooney DS; Fletcher DR; Bonawitz SC [Ad] Address: From the *Department of Plastic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; and †Division of Plastic and Reconstructive Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA. [Ti] Title: Successful replantation of an amputated midfacial segment: technical details and lessons learned. [So] Source: Ann Plast Surg;70(6):663-5, 2013 Jun. [Is] ISSN: 1536-3708 [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: Successful microvascular replantation of amputated facial tissues has been sporadically reported in the literature, although most of these reports have concerned the reattachment of relatively small and segmental portions of the nose or nasal tip. We report the successful replantation of a traumatically amputated composite piece of tissue comprising the entire nose, most of the upper and lower lips, and the nasal boney and cartilaginous complex based on microvascular repair of the labial arteries and glabellar veins and discuss the results and implications of this experience. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1305 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.1097/SAP.0b013e3182468216

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[PMID]: 23555308 [Au] Autor: Matsuda S; Blanco J; Shimmi O [Ad] Address: Institute of Biotechnology, University of Helsinki, Helsinki, Finland. [Ti] Title: A feed-forward loop coupling extracellular BMP transport and morphogenesis in Drosophila wing. [So] Source: PLoS Genet;9(3):e1003403, 2013 Mar. [Is] ISSN: 1553-7404 [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: A variety of extracellular factors regulate morphogenesis during development. However, coordination between extracellular signaling and dynamic morphogenesis is largely unexplored. We address the fundamental question by studying posterior crossvein (PCV) development in Drosophila as a model, in which long-range BMP transport from the longitudinal veins plays a critical role during the pupal stages. Here, we show that RhoGAP Crossveinless-C (Cv-C) is induced at the PCV primordial cells by BMP signaling and mediates PCV morphogenesis cell-autonomously by inactivating members of the Rho-type small GTPases. Intriguingly, we find that Cv-C is also required non-cell-autonomously for BMP transport into the PCV region, while a long-range BMP transport is guided toward ectopic wing vein regions by loss of the Rho-type small GTPases. We present evidence that low level of ß-integrin accumulation at the basal side of PCV epithelial cells regulated by Cv-C provides an optimal extracellular environment for guiding BMP transport. These data suggest that BMP transport and PCV morphogenesis are tightly coupled. Our study reveals a feed-forward mechanism that coordinates the spatial distribution of extracellular instructive cues and morphogenesis. The coupling mechanism may be widely utilized to achieve precise morphogenesis during development and homeostasis. [Pt] Publication type: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Entry month: 1304 [Js] Journal subset: IM [St] Status: In-Process [do] DOI: 10.1371/journal.pgen.1003403

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[PMID]: 22702537 [Au] Autor: Sousa CN; Apóstolo JL; Figueiredo MH; Martins MM; Dias VF [Ad] Address: Escola Superior Enfermagem do Porto, Porto, Portugal. clementesousa@esenf.pt [Ti] Title: Physical examination: how to examine the arm with arteriovenous fistula. [So] Source: Hemodial Int;17(2):300-6, 2013 Apr. [Is] ISSN: 1542-4758 [Cp] Country of publication: Canada [La] Language: eng [Ab] Abstract: Physical examination has demonstrated its effectiveness in identifying complications of arteriovenous fistula (AVF). It should be initiated at the stage prior to the construction of the AVF and continue in its accomplishment, maturation, and subsequent use in the treatment of hemodialysis. Nurses should incorporate the physical examination in their practices, in order to preserve the vascular net of patients and assist in the recognition of complications of AVF. It is intended to describe aspects of the physical examination that enable the identification of the AVF complications including: infection, accessory veins, venous stenosis, steal syndrome, high-output cardiac failure, and venous hypertension. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1304 [Js] Journal subset: IM [St] Status: In-Process [do] DOI: 10.1111/j.1542-4758.2012.00714.x

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[PMID]: 23529983 [Au] Autor: Kramer CK; Zinman B; Gross JL; Canani LH; Rodrigues TC; Azevedo MJ; Retnakaran R [Ad] Address: Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, 60 Murray Street, Suite L5-025, Mailbox-21, Toronto, ON, Canada M5T 3L9. [Ti] Title: Coronary artery calcium score prediction of all cause mortality and cardiovascular events in people with type 2 diabetes: systematic review and meta-analysis. [So] Source: BMJ;346:f1654, 2013. [Is] ISSN: 1756-1833 [Cp] Country of publication: England [La] Language: eng [Ab] Abstract: OBJECTIVE: To investigate the association of coronary artery calcium score with all cause mortality and cardiovascular events in people with type 2 diabetes. DESIGN: Systematic review and meta-analysis of observational studies. DATA SOURCES: Studies were identified from Embase, PubMed, and abstracts from the 2011 and 2012 annual meetings of the American Diabetes Association, European Association for the Study of Diabetes, American College of Cardiology, and American Heart Association (2011). ELIGIBILITY CRITERIA: Prospective studies that evaluated baseline coronary artery calcium score in people with type 2 diabetes and subsequent all cause mortality or cardiovascular events (fatal and non-fatal). DATA EXTRACTION: Two independent reviewers extracted the data. The predictive value of the coronary artery calcium score was assessed by random effects model. RESULTS: Eight studies were included (n=6521; 802 events; mean follow-up 5.18 years). The relative risk for all cause mortality or cardiovascular events, or both comparing a total coronary artery calcium score of ≥ 10 with a score of <10 was 5.47 (95% confidence interval 2.59 to 11.53; I(2)=82.4%, P<0.001). The overall sensitivity of a total coronary artery calcium score of ≥ 10 for this composite outcome was 94% (95% confidence interval 89% to 96%), with a specificity of 34% (24% to 44%). The positive and negative likelihood ratios were 1.41 (95% confidence interval 1.20 to 1.66) and 0.18 (0.10 to 0.30), respectively. For people with a coronary artery calcium score of <10, the post-test probability of the composite outcome was about 1.8%, representing a 6.8-fold reduction from the pretest probability. Four studies evaluated cardiovascular events as the outcome (n=1805; 351 events). The relative risk for cardiovascular events comparing a total coronary artery calcium score of ≥ 10 with a score of <10 was 9.22 (2.73 to 31.07; I(2)=76.7%, P=0.005). The positive and negative likelihood ratios were 1.67 (1.30 to 2.17) and 0.11 (0.04 to 0.29), respectively. CONCLUSION: In people with type 2 diabetes, a coronary artery calcium score of ≥ 10 predicts all cause mortality or cardiovascular events, or both, and cardiovascular events alone, with high sensitivity but low specificity. Clinically, the finding of a coronary artery calcium score of <10 may facilitate risk stratification by enabling the identification of people at low risk within this high risk population. [Mh] MeSH terms primary: Cardiovascular Diseases/epidemiology Coronary Vessels/pathology Diabetes Mellitus, Type 2/epidemiology Vascular Calcification/epidemiology [Mh] MeSH terms secundary: Cause of Death Coronary Vessels/radiography Diabetes Mellitus, Type 2/pathology Female Humans Male Predictive Value of Tests Severity of Illness Index Vascular Calcification/radiography [Pt] Publication type: JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW [Em] Entry month: 1305 [Js] Journal subset: AIM; IM [Da] Date of entry for processing: 130326 [St] Status: MEDLINE

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[PMID]: 23522200 [Au] Autor: Li W [Ad] Address: Department of Cellular and Molecular Medicine, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA. liw4@ccf.org [Ti] Title: Invited commentary. [So] Source: Ann Thorac Surg;95(4):1339, 2013 Apr. [Is] ISSN: 1552-6259 [Cp] Country of publication: Netherlands [La] Language: eng [Mh] MeSH terms primary: Bone Morphogenetic Protein 4/biosynthesis Diabetes Mellitus, Type 2/complications Endothelium, Vascular/physiopathology Myocardial Ischemia/surgery Myocardial Revascularization/methods Saphenous Vein/transplantation Vasoconstriction/physiology [Mh] MeSH terms secundary: Animals Female Humans Male [Pt] Publication type: COMMENT; JOURNAL ARTICLE [Nm] Name of substance: 0 (Bone Morphogenetic Protein 4) [Em] Entry month: 1305 [Js] Journal subset: AIM; IM [Da] Date of entry for processing: 130325 [St] Status: MEDLINE

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[PMID]: 23522199 [Au] Autor: Hu J; Liu J; Kwok MW; Wong RH; Huang Y; Wan S [Ad] Address: Division of Cardiothoracic Surgery, Department of Surgery, Prince of Wales Hospital, and Institute of Vascular Medicine, School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, People's Republic of China. [Ti] Title: Bone morphogenic protein-4 contributes to venous endothelial dysfunction in patients with diabetes undergoing coronary revascularization. [So] Source: Ann Thorac Surg;95(4):1331-9, 2013 Apr. [Is] ISSN: 1552-6259 [Cp] Country of publication: Netherlands [La] Language: eng [Ab] Abstract: BACKGROUND: Hyperglycemia-induced venous endothelial dysfunction accelerates the progression of vein graft failure in patients with diabetes undergoing surgical coronary revascularization. Recent studies suggest the importance of bone morphogenic protein-4 (BMP4)-induced arterial endothelial dysfunction in the development of hypertension and atherosclerosis. The present study investigated the potential role of BMP4 in the pathogenesis of venous endothelial dysfunction in the setting of diabetes. METHODS: Segments of saphenous vein from pigs and from patients with diabetes or patients without diabetes, as well as human umbilical venous endothelial cells (HUVECs), were used. The changes of BMP4 expression in veins from patients and in HUVECs cultured under hyperglycemic conditions were evaluated by Western blot assay. The effects of BMP4 on the production of reactive oxygen species (ROS) and endothelium-dependent venous relaxation were assessed by using dihydroethidium fluorescence and isometric tension measurements, respectively. RESULTS: The impaired venous endothelium-dependent relaxations (2.9%±4.8% versus control group 74.1%±10%; p<0.01) accompanied by markedly increased BMP4 expression were observed in the diabetic group. The level of BMP4 expression in HUVECs treated with high levels of glucose were elevated in a glucose concentration-dependent manner. Ex vivo treatment with the BMP4 antagonist noggin significantly improved endothelium-dependent relaxations and inhibited accumulation of ROS in saphenous veins from patients with diabetes. Noggin treatment had no effect on the venous endothelium-dependent relaxations in individuals without diabetes. Meanwhile, BMP4 inhibited acetylcholine-induced relaxation (control group, 90%±7.1% versus BMP4-treated group, 52%±12.6%; p<0.05) and enhanced ROS production in porcine saphenous veins. Such harmful effects were again reversed by noggin. CONCLUSIONS: The increased BMP4 expression and related ROS overproduction may play an important role in the development of hyperglycemia-induced venous endothelial dysfunction. [Mh] MeSH terms primary: Bone Morphogenetic Protein 4/biosynthesis Diabetes Mellitus, Type 2/complications Endothelium, Vascular/physiopathology Myocardial Ischemia/surgery Myocardial Revascularization/methods Saphenous Vein/transplantation Vasoconstriction/physiology [Mh] MeSH terms secundary: Aged Animals Blotting, Western Cells, Cultured Diabetes Mellitus, Type 2/metabolism Endothelium, Vascular/metabolism Female Human Umbilical Vein Endothelial Cells/metabolism Human Umbilical Vein Endothelial Cells/pathology Humans Male Middle Aged Myocardial Ischemia/complications Myocardial Ischemia/physiopathology Saphenous Vein/metabolism Saphenous Vein/physiopathology Swine [Pt] Publication type: COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Name of substance: 0 (Bone Morphogenetic Protein 4) [Em] Entry month: 1305 [Js] Journal subset: AIM; IM [Da] Date of entry for processing: 130325 [St] Status: MEDLINE

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[PMID]: 23462260 [Au] Autor: Bojan M; Peperstraete H; Lilot M; Tourneur L; Vouhé P; Pouard P [Ad] Address: Department of Anesthesia and Critical Care, Necker-Enfants Malades Hospital, Assistance Publique, Hôpitaux de Paris, and Paris Descartes University, School of Medicine, Paris, France. mirela.bojan@nck.aphp.fr [Ti] Title: Cold histidine-tryptophan-ketoglutarate solution and repeated oxygenated warm blood cardioplegia in neonates with arterial switch operation. [So] Source: Ann Thorac Surg;95(4):1390-6, 2013 Apr. [Is] ISSN: 1552-6259 [Cp] Country of publication: Netherlands [La] Language: eng [Ab] Abstract: BACKGROUND: The present study aimed to compare myocardial protection, as assessed by cardiac troponin-I release, and short-term outcomes between two groups of neonates undergoing the arterial switch operation (ASO) with either Custodiol cardioplegia (Custodiol HTK, Köhler Chemie GmbH, Bensheim, Germany) or repeated oxygenated warm blood cardioplegia. METHODS: A total of 218 neonates were enrolled retrospectively from February 2007 through February 2011. All analyses were stratified on the type of procedure (ASO±ventricular septal defect closure ± aortic arch repair). Troponin concentrations within the first week of surgery were analyzed using mixed models for repeated measurements. To counteract the confounding effect of the coronary anatomy, a sensitivity analysis was conducted after 1:1 matching. RESULTS: Overall 30 patients had Custodiol cardioplegia, and 188 had warm blood cardioplegia. High-risk coronary anatomy (single right coronary artery giving rise to the left, intramural course) was associated with higher troponin concentrations and a higher 30-day mortality rate postoperatively, and was more prevalent in the Custodiol group when compared with the warm blood cardioplegia group. Postoperative troponin concentrations were higher in the Custodiol group both before (p<0.001) and after matching on the coronary anatomy (p=0.03). The 30-day mortality rate was higher in the Custodiol group, 10% versus 1.1% (p=0.009), but only a nonsignificant trend was noted after matching. CONCLUSIONS: The use of Custodiol cardioplegia in neonates undergoing ASO was associated with a larger troponin release when compared with warm blood cardioplegia, suggesting poor myocardial protection. The difference noted in 30-day mortality was not due to the use of Custodiol. [Mh] MeSH terms primary: Blood Transfusion/methods Cardiac Surgical Procedures/methods Coronary Vessels/surgery Heart Arrest, Induced/methods Heart Defects, Congenital/surgery [Mh] MeSH terms secundary: Cardioplegic Solutions/pharmacology Female Follow-Up Studies Glucose/pharmacology Humans Infant, Newborn Male Mannitol/pharmacology Oxygen Potassium Chloride/pharmacology Procaine/pharmacology Retrospective Studies Temperature [Pt] Publication type: COMPARATIVE STUDY; JOURNAL ARTICLE [Nm] Name of substance: 0 (Bretschneider cardioplegic solution); 0 (Cardioplegic Solutions); 50-99-7 (Glucose); 59-46-1 (Procaine); 69-65-8 (Mannitol); 7447-40-7 (Potassium Chloride); 7782-44-7 (Oxygen) [Em] Entry month: 1305 [Js] Journal subset: AIM; IM [Da] Date of entry for processing: 130325 [St] Status: MEDLINE

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