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[PMID]: 27217000
[Au] Autor:Zheng H; Wei Z; Xin G; Ji C; Wen L; Xia Q; Niu H; Huang W
[Ad] Address:Laboratory of Ethnopharmacology, Institute for Nanobiomedical Technology and Membrane Biology, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China; Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, West ...
[Ti] Title:Preventive effect of a novel diosgenin derivative on arterial and venous thrombosis in vivo.
[So] Source:Bioorg Med Chem Lett;26(14):3364-9, 2016 Jul 15.
[Is] ISSN:1464-3405
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Current therapy for blood vessel thrombosis has the risk of leading to gastrointestinal bleeding and thrombocytopenia. We previously reported that a new derivative of diosgenin, compound 5, had significant anti-inflammatory activity superior to that of aspirin, prolonged bleeding time, and inhibited platelet aggregation in vitro. In the present study, we investigated the in vivo efficacy and safety of compound 5 using the ferric chloride (FeCl3)-induced arterial and venous thrombosis models in rats as well as its toxicity in mice. Compared with the control rats, those treated with compound 5 showed significantly less adenosine diphosphate (ADP)-induced platelet aggregation and a prolonged activated partial thromboplastin time mediated by the specific regulation of factor VIII. Furthermore, compound 5 significantly reduced the average length and weight of thrombi in both arteries and veins. These findings were similar to those of aspirin at the same dose. The safety evaluation revealed a much lower risk of bleeding and lesser gastric mucosal damage with compound 5 than with the same dose of aspirin. An oral dose of up to 575.5mg/kg showed no toxicity in mice. In conclusion, consistent with our in vitro findings, compound 5 exhibited an in vivo antithrombotic activity that was comparable to aspirin mainly by reducing platelet aggregation and regulating factor VIII, but with fewer side effects.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Js] Journal subset:IM
[St] Status:In-Data-Review

  2 / 165759 MEDLINE  
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[PMID]: 26212075
[Au] Autor:Berres ML; Lehmann J; Jansen C; Görtzen J; Meyer C; Thomas D; Zimmermann HW; Kroy D; Schumacher F; Strassburg CP; Sauerbruch T; Trautwein C; Wasmuth HE; Trebicka J
[Ad] Address:Department of Internal Medicine III, RTWH Aachen, Aachen, Germany....
[Ti] Title:Chemokine (C-X-C motif) ligand 11 levels predict survival in cirrhotic patients with transjugular intrahepatic portosystemic shunt.
[So] Source:Liver Int;36(3):386-94, 2016 Mar.
[Is] ISSN:1478-3231
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND & AIMS: Chemokines, such as CXCR3-ligands, have been identified to play an important role during hepatic injury, inflammation and fibrosis. While CXCL9 is associated with survival in patients receiving transjugular intrahepatic portosystemic shunt (TIPS), the role of CXCL11 in severe portal hypertension remains unknown. METHODS: CXCL11-levels were measured in 136 patients with liver diseases, and 63 healthy controls. In further 47 cirrhotic patients receiving TIPS, CXCL11 levels were measured in portal and hepatic veins at TIPS insertion by cytometric bead array. CXCL11-levels were measured in 23 patients in cubital vein and right atrium, whereas in 24 patients in portal and hepatic blood at an invasive reevaluation. RESULTS: CXCL11-levels were increased with the severity of liver fibrosis. CXCL11-levels from portal, hepatic and cubital veins and right atrium showed a highly significant correlation among each other in these patients. Furthermore, levels of CXCL11 from the right atrium were significantly higher than those from cubital vein. Interestingly, patients with alcoholic cirrhosis had significantly lower CXCL11-levels, than other aetiologies of cirrhosis. After TIPS, CXCL11 levels correlated with the degree of portal pressure and patients with higher CXCL11-levels in portal and hepatic veins showed higher mortality. Multivariate analysis revealed hepatic CXCL11-levels before TIPS, creatinine and age as independent predictors for survival in TIPS patients, whereas MELD score and low portal CXCL11-levels after TIPS predicted long-term survival. CONCLUSION: CXCL11 levels are mainly increased in patients with non-alcoholic cirrhosis and high portal pressure. Moreover, levels of CXCL11 might predict long-time survival of cirrhotic patients bearing TIPS.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1602
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1111/liv.12922

  3 / 165759 MEDLINE  
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[PMID]: 26873170
[Au] Autor:Zarshenas MM; Zargaran A; Mehdizadeh A; Mohagheghzadeh A
[Ad] Address:Student Research Committee, Department of history of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Research Office for the History of Persian Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Department of Traditional Pharmacy, School of Pharmacy, Shiraz University of Med...
[Ti] Title:Mansur ibn Ilyas (1380-1422 AD): A Persian anatomist and his book of anatomy, Tashrih-i Mansuri.
[So] Source:J Med Biogr;24(1):67-71, 2016 Feb.
[Is] ISSN:1758-1087
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:A Persian scholar, Mansur ibn Elyas, a late 14th century anatomist and physician from Shiraz, published his illustrated book on anatomy. Mansur's anatomy (Tashrih-i Badan-i Insan) was written following the Mansur's medical synopsis, Kefaye Mojahedieh. The book of Mansur is believed to be the first anatomical illustrated manuscript containing two-dimensional pictures of the human body. This 14th-century treatise is composed in Persian and is organized into five articles on the skeleton, nerves, muscles, veins and arteries, each illustrated with a full page diagram and with a final chapter including an image of a pregnant woman delivering a breech baby. These chapters have description part and related figure involving brief explanation. Mansur's illustrations were often used in other Persian or Arabic medical manuscripts for at least two centuries in Persia.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1602
[Js] Journal subset:IM; QIS
[St] Status:In-Process
[do] DOI:10.1177/0967772013479474

  4 / 165759 MEDLINE  
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[PMID]: 27171945
[Au] Autor:Hu W; Henry AS; Lucas C; Ta P; Philandrianos C; Kerfant N
[Ad] Address:Plastic Surgery Department, CHRU Brest, Brest Cedex, France.
[Ti] Title:Microsurgical Replantation of a Two-Segment Total Scalp Avulsion.
[So] Source:J Craniofac Surg;27(4):1068-9, 2016 Jun.
[Is] ISSN:1536-3732
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Total scalp avulsion is a rare and severe injury that may be life threatening and can result in devastating disfigurement and psychological trauma. Microsurgical hair-bearing scalp replantation is considered the procedure of choice and should be performed by a skilled surgical team. Replantation of a multifragmented scalp is even rarer and shows random results. Only 2 patients have been reported, resulting in partial or total necrosis of implanted fragments. The authors describe the successful replantation of a totally avulsed 2-segment scalp in a 63-year-old woman whose hair was entrapped in the propeller shaft of a ship. The avulsed scalp involved both eyebrows, the frontal region, the upper part of both ears, and most of the occipital portion. After initial management including correction of hemorrhagic shock, the patient underwent emergency scalp replantation by microsurgical anastomosis of 3 arteries and 4 veins and the use of 2 vein grafts.According to authors' experience, multifragmented scalp avulsion imposes emergency relocation using as many microsurgical sutures as possible and implementation of vein grafts to ensure optimal revascularization of the avulsed scalp.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Js] Journal subset:D
[St] Status:In-Data-Review
[do] DOI:10.1097/SCS.0000000000002637

  5 / 165759 MEDLINE  
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[PMID]: 26494644
[Au] Autor:Morita S; Nishina Y; Yamazaki H; Sonoyama Y; Ichihara A; Sakai S
[Ad] Address:Department of Diagnostic Imaging and Nuclear Medicine (Radiology), Tokyo Women's Medical University Hospital, 8-1, Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan. i@imodey.com....
[Ti] Title:Dual adrenal venous phase contrast-enhanced MDCT for visualization of right adrenal veins in patients with primary aldosteronism.
[So] Source:Eur Radiol;26(7):2073-7, 2016 Jul.
[Is] ISSN:1432-1084
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:PURPOSE: To evaluate the frequency of visualization of the right adrenal vein (RAV) on dual adrenal venous phase multi-detector computed tomography (MDCT) in patients with primary aldosteronism. MATERIALS AND METHODS: Images of contrast-enhanced dual adrenal venous phase MDCT (45- and 55-second delays) in 90 patients with primary aldosteronism who underwent adrenal venous sampling were retrospectively evaluated. The degree of RAV visualization on each phase image was evaluated by two radiologists using a five-point scale and RAV visualization rates were estimated. RESULTS: The RAV visualization rates on the first- and second-phase images were 89 % and 91 % by radiologist A, and 93 % and 90 % by radiologist B, respectively. No significant differences in the score of RAV visualization were observed between the first- and second-phase images by the two readers (P = 0.164 and P = 0.06). The kappa values for inter-observer agreement of RAV visualization on the first- and second-phase images were 0.57 and 0.46, respectively. The consensual RAV visualization rates on the first- and second-phase images were 91 % and 92 %, respectively. The overall RAV visualization rate by using both phase images was 98 %. CONCLUSION: Dual adrenal venous phase MDCT can visualize the RAV in almost all patients with primary aldosteronism. KEY POINTS: • Dual adrenal venous phase MDCT images can visualize the right adrenal veins. • The adrenal venous phase lies between the arterial and portal phases. • Anatomical information will contribute to the technical success of adrenal venous sampling.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s00330-015-4073-9

  6 / 165759 MEDLINE  
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[PMID]: 26486938
[Au] Autor:Kim JH; Choo KS; Moon TY; Lee JW; Jeon UB; Kim TU; Hwang JY; Yun MJ; Jeong DW; Lim SJ
[Ad] Address:Department of Radiology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Pusan, Korea....
[Ti] Title:Comparison of the image qualities of filtered back-projection, adaptive statistical iterative reconstruction, and model-based iterative reconstruction for CT venography at 80 kVp.
[So] Source:Eur Radiol;26(7):2055-63, 2016 Jul.
[Is] ISSN:1432-1084
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:PURPOSE: To evaluate the subjective and objective qualities of computed tomography (CT) venography images at 80 kVp using model-based iterative reconstruction (MBIR) and to compare these with those of filtered back projection (FBP) and adaptive statistical iterative reconstruction (ASIR) using the same CT data sets. MATERIALS AND METHODS: Forty-four patients (mean age: 56.1 ± 18.1) who underwent 80 kVp CT venography (CTV) for the evaluation of deep vein thrombosis (DVT) during 4 months were enrolled in this retrospective study. The same raw data were reconstructed using FBP, ASIR, and MBIR. Objective and subjective image analysis were performed at the inferior vena cava (IVC), femoral vein, and popliteal vein. RESULTS: The mean CNR of MBIR was significantly greater than those of FBP and ASIR and images reconstructed using MBIR had significantly lower objective image noise (p < .001). Subjective image quality and confidence of detecting DVT by MBIR group were significantly greater than those of FBP and ASIR (p < .005), and MBIR had the lowest score for subjective image noise (p < .001). CONCLUSION: CTV at 80 kVp with MBIR was superior to FBP and ASIR regarding subjective and objective image qualities. KEY POINTS: • MBIR provides superior image quality compared with FBP and ASIR • CTV at 80kVp with MBIR improves diagnostic confidence in diagnosing DVT • CTV at 80kVp with MBIR presents better image quality with low radiation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s00330-015-4060-1

  7 / 165759 MEDLINE  
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[PMID]: 27273682
[Au] Autor:Livi F; Ndoro S; Caird J; Crimmins D
[Ad] Address:Department of Paediatric Neurosurgery, Temple St. Children's University Hospital, Dublin, Ireland livi.francesca@gmail.com....
[Ti] Title:Indirect cavernous carotid fistula in a 12-year-old girl.
[So] Source:J Surg Case Rep;2016(6), 2016.
[Is] ISSN:2042-8812
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:We present a very rare case of indirect cavernous carotid fistula (CCF) in a 12-year-old girl. Indirect CCF is extremely rare in the paediatric population. A 12-year-old girl presented with a 7-month history of frontal headaches and intermittent left-sided proptosis. On examination, she had dilated and engorged scleral veins on the left eye, mild dysdiadochokinesia and past pointing on the left side. A brain computer tomography with contrast, brain magnetic resonance imaging (MRI) and interventional radiography (IR) cerebral angiogram confirmed the diagnosis of CCF. The CCF was embolized and a follow-up brain MRI and an IR cerebral angiogram were conducted over the course of 8 months that revealed no evidence of residual CCF. CCF, though rare in the paediatric population, should be highly considered in the differential diagnosis when dilated scleral veins, proptosis and dysdiadokinesis are present in the clinical setting. Prompt treatment has good prognostic results.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Cu] Class update date: 160610
[Lr] Last revision date:160610
[Da] Date of entry for processing:160609
[St] Status:PubMed-not-MEDLINE

  8 / 165759 MEDLINE  
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[PMID]: 27275471
[Au] Autor:Salloum C; Lim C; Lahat E; Compagnon P; Azoulay D
[Ad] Address:1 Department of Hepato-Pancreato-Biliary and Liver Transplantation, Henri Mondor Hospital, Créteil, France ; 2 INSERM U965, Paris, France ; 3 INSERM U955, Créteil, France....
[Ti] Title:The veno-venous bypass in liver transplantation: an unfinished product.
[So] Source:Hepatobiliary Surg Nutr;5(3):269-72, 2016 Jun.
[Is] ISSN:2304-3881
[Cp] Country of publication:China (Republic : 1949- )
[La] Language:eng
[Ab] Abstract:Veno-venous bypass (VVB) using a patent para-umbilical vein during liver transplantation (LT) has not been reported previously. Here, we report the decompression of the porto-mesenteric compartment via a patent para-umbilical vein in a patient needing a VVB during LT. Pre-transplant CT-scan showed a large patent para-umbilical vein. A femoro-axillary percutaneous VVB was installed prior to abdominal opening to decompress massive collateral veins in the abdominal wall. The para-umbilical vein was stapled and its proximal end was cannulated and connected to the VVB. The severe atrophy of the native liver allowed to place the whole liver graft in the "liver fossa" while maintaining the native liver pulled toward the left side and connected to the VVB. This maneuver maintained splanchnic venous decompression during latero-lateral cavo-caval anastomosis. The "portal" cannula was clamped and removed. The native portal vein was clamped and divided. Standard portal, arterial, and biliary reconstructions were then performed. A patent para-umbilical vein, present in one third of patients with portal hypertension could be used whenever VVB is indicated during LT in this setting.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Cu] Class update date: 160610
[Lr] Last revision date:160610
[Da] Date of entry for processing:160609
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.21037/hbsn.2016.02.03

  9 / 165759 MEDLINE  
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[PMID]: 25846113
[Au] Autor:Krishnamurthy LC; Mao D; King KS; Lu H
[Ad] Address:Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA....
[Ti] Title:Correction and optimization of a T2-based approach to map blood oxygenation in small cerebral veins.
[So] Source:Magn Reson Med;75(3):1100-9, 2016 Mar.
[Is] ISSN:1522-2594
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: Cerebral venous blood oxygenation (Yv ) is an important biomarker in brain physiology and function. The present study proposes a procedure to provide a quantitative map of the brain's intravascular Yv. THEORY AND METHODS: The method is based on a pulse sequence, T2 -Relaxation-Under-Phase-Contrast (TRU-PC) MRI, with postprocessing approaches to correct eddy-current effects. A complete scan protocol consists of four TRU-PC scans sensitized to large and small vessels with anterior-posterior and foot-head flow-encoding directions, and the data are analyzed conjunctively. Eddy-current correction was performed by fitting the tissue phase to a hyperplane, and then subtracting the eddy-current phase from the measured vessel phase. The reproducibility of the Yv-maps was examined in five participants. Sensitivity of the Yv map to a caffeine challenge was studied in another five participants. RESULTS: Removal of eddy-current induced artifact allowed for the correction of T2 measurements, as demonstrated in vivo and with simulation. A Yv-map depicting all vessels in the slice can be obtained with the proposed protocol. Test-retest variability of the Yv -map was 3.7 ± 1.2%. Yv reduction can be reliably detected (P < 0.001) following the caffeine ingestion. CONCLUSION: With the proposed TRU-PC protocol and eddy-current correction procedure, an accurate, vessel-specific Yv map of the human brain can be obtained.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Entry month:1602
[Cu] Class update date: 160215
[Lr] Last revision date:160215
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1002/mrm.25686

  10 / 165759 MEDLINE  
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[PMID]: 26705300
[Au] Autor:Geuzebroek GS; Bentala M; Molhoek SG; Kelder JC; Schaap J; Van Putte BP
[Ad] Address:Department of Cardio-Thoracic Surgery, St Antonius Hospital, Nieuwegein, Netherlands g.s.c.geuzebroek@gmail.com....
[Ti] Title:Totally thoracoscopic left atrial Maze: standardized, effective and safe.
[So] Source:Interact Cardiovasc Thorac Surg;22(3):259-64, 2016 Mar.
[Is] ISSN:1569-9285
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVES: The totally thoracoscopic left atrial Maze (TT-Maze) is a relatively new surgical solution for the treatment of atrial fibrillation (AF). The procedure consists of a complete left atrial Maze, which is performed by video-assisted thoracoscopy with the use of radiofrequency ablation. We describe our rhythm results as well as our learning curve experience of the TT-Maze. METHODS: To evaluate the learning curve, all consecutive patients who underwent a TT-Maze and were operated by one surgeon (Bart P. Van Putte) were included in the study. The endpoint of surgery was sinus rhythm with a bidirectional block of the box and pulmonary veins. RESULTS: A total of 83 patients were included. Fifty percent of the patients had paroxysmal AF. The mean indexed left atrial volume was 44 ± 15 ml/m(2) and 38% of the patients had a previous catheter ablation for AF. During a mean follow-up of 10.9 ± 4.9 months, there were no major events. At latest follow-up, 82% of the patients did not have a single registration of AF or other atrial tachyarrhythmias longer than 30 s. Patients without AF were also free from anti-arrhythmic drugs in 90% of the cases, free from coumadins or direct oral anticoagulants in 63% of the cases and free from both in 58% of the cases. CONCLUSIONS: After almost 1-year follow-up, the TT-Maze is proved to be a successful, safe and reproducible strategy for the treatment of all types of AF including patients with enlarged left atria and previously failed catheter ablation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1602
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1093/icvts/ivv358


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