Database : MEDLINE
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[PMID]: 24831656
[Au] Autor:Chik WW; Chan JK; Ross DL; Wagstaff J; Kizana E; Thiagalingam A; Kovoor P; Thomas SP
[Ad] Address:Cardiology Department, Westmead Public and Private Hospitals, Sydney, Australia; Sydney Medical School, University of Sydney, Sydney, Australia.
[Ti] Title:Atrial tachycardias utilizing the ligament of marshall region following single ring pulmonary vein isolation for atrial fibrillation.
[So] Source:Pacing Clin Electrophysiol;37(9):1149-58, 2014 Sep.
[Is] ISSN:1540-8159
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Organized atrial tachycardias (OATs) after pulmonary vein isolation (PVI) procedure are common. Arrhythmia mechanisms include mitral annular, ring gap, or roof-dependent gap-related flutters. In this series, we describe a mechanism of arrhythmia utilizing the ridge between left pulmonary vein (PV) and left atrial appendage (LAA) in the Ligament of Marshall (LOM) region. METHODS AND RESULTS: Five tachycardias involving the LOM region were identified from a group of 240 patients who underwent a single ring PVI procedure for symptomatic atrial fibrillation. The common characteristics of these tachycardias were the endocardial breakout over a broad area adjacent to the LOM region, presence of presystolic or mid-diastolic potentials, and abolition by ablation of the presystolic or mid-diastolic potentials remote from the endocardial breakout site. In all five cases, tachycardias were present after isolation of the veins and posterior left atria. All demonstrated characteristic areas of very slow conduction in the LOM region highlighted by presence of either low voltage, long duration fractionated potentials, or mid-diastolic potentials with a fixed temporal relationship to the subsequent endocardial activation. The pattern of activation and termination of tachycardia during ablation was consistent with an arrhythmia utilizing an electrically insulated tract within LOM and the PV-LAA ridge region. CONCLUSIONS: We identified a pattern of arrhythmias involving a concealed presystolic component and a broad endocardial breakout site related to the LOM region. Successful ablation site involved careful identification of small diastolic potentials in the LAA/ridge region or adjacent to the coronary sinus.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/pace.12423

  2 / 156437 MEDLINE  
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[PMID]: 25196622
[Au] Autor:Yakovlev SB; Bocharov AV; Mikeladze K; Gasparian SS; Serova NK; Shakhnovich AR
[Ad] Address:Neurosurgery Institute, Russian Academy of Medical Sciences; Moscow, Russian Federation - kmikeladze@gmail.com....
[Ti] Title:Endovascular treatment of acute thrombosis of cerebral veins and sinuses.
[So] Source:Neuroradiol J;27(4):471-8, 2014 Sep.
[Is] ISSN:1971-4009
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:Acute thrombosis of cerebral veins and sinuses (ATCVS) is a multifactorial disease with grave consequences. Because of its rare occurrence there are no proven treatment guidelines. Sixteen patients with ATCVS were treated. The final diagnosis was confirmed by digital subtraction angiography. Sinus catheterization was performed via transfemoral venous access. Treatment included mechanical manipulation of thrombi and thrombolytic therapy. A regression of clinical symptoms with a concomitant decrease of intracranial hypertension was achieved in all patients. Long-term results were studied in eight patients: none presented clinical signs of intracranial hypertension. Endovascular transvenous recanalization is an effective treatment for acute thrombosis of cerebral veins and sinuses. Along with the local thrombolysis, significant potential in the treatment of this complex pathology lies in the transvenous endovascular techniques of mechanical thrombus extraction, especially in patients with intracranial hemorrhage for whom the use of thrombolytic agents is restricted.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.15274/NRJ-2014-10066

  3 / 156437 MEDLINE  
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[PMID]: 25196621
[Au] Autor:Pashapour A; Mohammadian R; Salehpour F; Sharifipour E; Mansourizade R; Mahdavifard A; Salehi M; Mirzaii F; Sariaslani P; Ardalani GF; Altafi D
[Ad] Address:Neurology Department, Tabriz University of Medical Sciences; Tabriz, Iran - diako30@yahoo.com - mohammadianr@tbzmed.ac.ir....
[Ti] Title:Long-Term Endovascular Treatment Outcome of 46 Patients with Cavernous Sinus Dural Arteriovenous Fistulas Presenting with Ophthalmic Symptoms. A Non-Controlled Trial with Clinical and Angiographic Follow-up.
[So] Source:Neuroradiol J;27(4):461-70, 2014 Sep.
[Is] ISSN:1971-4009
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:Ocular symptoms are regularly observed in patients with cavernous sinus dural arteriovenous fistulas (cDAVF). We aimed to evaluate the long-term efficacy and safety of endovascular approaches in patients with cDAVF presenting with different ocular symptoms. In a prospective study between June 2008 and March 2013, 46 patients with ocular symptoms due to cDAVF who were not eligible for conservative therapy, met the inclusion criteria and underwent endovascular treatment. They underwent a transarterial approach with histoacryl glue injections or transvenous coil embolization, all in one session. They were followed up for a mean period of 17.3 months (range 7 to 30 months) clinically and using angiography. The mean age of patients was 36.8 years (18-60) and 65% of them were male. All patients showed venous drainage into the superior and inferior orbital veins. Access to the cavernous sinus was transvenous in ten patients, transarterial in 26 patients, and mixed in ten patients. Initial symptoms were improved in 97.8% of patients and did not recur during the study follow-up. The procedural complications included: blurred vision, transient sixth nerve palsy and exacerbation of chemoproptosis in two, one and two patients respectively that completely resolved in initial weeks with no recurrence. No patient worsened or developed new symptoms suggestive of a recurrent fistula during the follow-up period. One patient experienced intracranial dissection of the internal carotid artery and ischemic stroke with an unfinished procedure. The relief of early presentation was durable in long-term follow-up and the cured lesions were stable in angiographic controls. Favorable and durable outcomes could be obtained following endovascular approaches for cDAVF presenting with different ocular symptoms.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.15274/NRJ-2014-10079

  4 / 156437 MEDLINE  
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[PMID]: 24033676
[Au] Autor:Messina SA; Poretti A; Tekes A; Robertson C; Johnston MV; Huisman TA
[Ad] Address:Divisions of Neuroradiology, Baltimore, MD.
[Ti] Title:Early Predictive Value of Susceptibility Weighted Imaging (SWI) in Pediatric Hypoxic-Ischemic Injury.
[So] Source:J Neuroimaging;24(5):528-30, 2014 Sep.
[Is] ISSN:1552-6569
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Susceptibility weighted imaging (SWI) provides information about the intravascular cerebral blood oxygenation level. Deoxyhemoglobin is increased in tissue with increased oxygen extraction fraction. Accordingly, the draining veins in hypoxic-ischemic brain may reveal abnormally low SWI signal. We report on a boy with hypoxic-ischemic injury (HII) after cardiac arrest and the ability of SWI to depict areas of HII by focusing on the venous cerebral drainage.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/jon.12043

  5 / 156437 MEDLINE  
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[PMID]: 24033644
[Au] Autor:Lochner P; Nedelmann M; Kaps M; Stolz E
[Ad] Address:Department of Neurology, Justus-Liebig University, Giessen, Germany; Department of Neurology, Krankenhaus Meran, Meran, Italy.
[Ti] Title:Jugular valve incompetence in transient global amnesia. A problem revisited.
[So] Source:J Neuroimaging;24(5):479-83, 2014 Sep.
[Is] ISSN:1552-6569
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND AND PURPOSE: Previous studies have suggested that transient global amnesia (TGA) may be provoked by cerebral venous congestion due to a reflux during Valsalva maneuver (VM) caused by internal jugular venous valve incompetence (IJVVI). We investigated the hemodynamic consequences of postural changes on IJVVI and on intracranial veins in patients with TGA and control subjects. MATERIALS AND METHODS: IJVVI was assessed by means of extracranial color-coded duplex sonography during VM in 28 patients with TGA and 25 controls. The basal vein Rosenthal was examined by transcranial color-coded sonography registering flow velocities (FV) at rest and during VM. These measurements were performed in the supine and in a sitting position. RESULTS: IJVVI was identified in supine position in 19/28 (68%) of TGA patients and in 7/25 (28%) of controls (P < .05). Body position had no effect on the detection of IJVVI. Intracranial venous FV at rest and during VM did neither differ between patients and controls, nor between persons with and without IJVVI. CONCLUSIONS: Consistent with results of other groups, we found a significantly higher rate of IJVVI in TGA patients compared to controls. However, we found no differences of intracranial venous circulation between groups nor an effect of body position. This sheds doubt on the assumption of a causative effect of IJVVI in TGA.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/jon.12042

  6 / 156437 MEDLINE  
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[PMID]: 25197411
[Au] Autor:Xiao D; Fu C; Long X; Liu W; Chen C; Zhou J; Fan S
[Ad] Address:Department of Pathology, Xiangya School of Medicine, Central South University Hunan, China....
[Ti] Title:Lung intravascular large B-cell lymphoma with ground glass opacities on chest computed tomography: a case report.
[So] Source:Int J Clin Exp Pathol;7(8):5285-90, 2014.
[Is] ISSN:1936-2625
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Intravascular large B-cell lymphoma (IVLBCL) is a rare type of extranodal large B-cell lymphoma characterized by the selective growth of lymphoma cells within the lumina of vessels, particularly within capillaries, with exception of larger arteries and veins. The authors reported a case of a 45-year-old woman who was admitted in hospital with refractory fever, cough and progressive dyspnea despite of receiving broad-spectrum antibiotics. Computed tomography (CT) of the lung showed bilateral patchy ground-glass opacities with some pleural effusion in the left lung. A CT-guided percutaneous lung biopsy was performed and primary pulmonary intravascular large B-cell lymphoma was diagnosed by histopathology, immunophenotype and fluorescence in situ hybridization. The patient's general status was improved after chemotherapy with R-CHOP. CT-guided percutaneous biopsy of lung is a safe and accurate diagnostic procedure in IVLBCL.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review

  7 / 156437 MEDLINE  
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[PMID]: 25193899
[Au] Autor:Zadeh MK; Shirvani A
[Ti] Title:The role of routine chest radiography for detecting complications after central venous catheter insertion.
[So] Source:Saudi J Kidney Dis Transpl;25(5):1011-6, 2014 Sep-Oct.
[Is] ISSN:1319-2442
[Cp] Country of publication:Saudi Arabia
[La] Language:eng
[Ab] Abstract:Chest radiographs are obtained routinely after central venous catheter (CVC) insertion in many institutions, although it consumes time and money. The purpose of this study was to evaluate the role of post-procedural chest X-ray in detecting complications of CVC insertion; we performed CVC insertion without using ultrasonography guidance. A total of 454 patients who required an emergency vascular access for hemodialysis between February 2008 and March 2010 were included in this study. In cases where three to five unsuccessful attempts were encountered to place the CVC or pierce the artery, we used another site for CVC placement or we placed the CVC under ultrasonographic guidance. Both the internal jugular and the subclavian veins were used as routes for catheter insertion. All the catheters were dual lumen and were inserted by the same vascular access surgeon. All the catheters were inserted using the same protocol. This protocol consists of five stages including position, percutaneous anesthesia, puncture, pull out and placement. Chest radiography was obtained after the procedure and patients were interviewed for the presence of any unusual symptoms. The X-rays were reviewed by a radiologist who was unaware of the patients' symptoms. Complications occurred in two patients who had unusual symptoms after the placement of the catheter. Although immediate postprocedural chest radiography is recommended for tip position confirmation, it should not be considered a reliable procedure for detecting complications in the absence of clinical symptoms. It is recommended to monitor patients after catheter insertion and perform delayed chest X-ray in the presence of any unusual symptoms.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review

  8 / 156437 MEDLINE  
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[PMID]: 25193295
[Au] Autor:Arbelo E; Guiu E; Ramos P; Bisbal F; Borras R; Andreu D; Tolosana JM; Berruezo A; Brugada J; Mont L
[Ad] Address:Unitat de Fibril lació Auricular (UFA), Institut del Tòrax, Hospital Clínic Universitat de Barcelona - Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain (E.A., E.G., P.R., F.B., R.B., D.A., J.M.T., A.B., J.B., L.M.)....
[Ti] Title:Benefit of left atrial roof linear ablation in paroxysmal atrial fibrillation: a prospective, randomized study.
[So] Source:J Am Heart Assoc;3(5), 2014.
[Is] ISSN:2047-9980
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Isolation of the pulmonary veins (PVs) for the treatment of atrial fibrillation (AF) is often supplemented with linear lesions within the left atrium (LA). However, there are conflicting data on the effects of creating a roof line (RL) joining the superior PVs in paroxysmal atrial fibrillation (PAF). METHODS AND RESULTS: A cohort of 120 patients with drug-refractory PAF referred for ablation were prospectively randomized into 2 strategies: (1) PV isolation in combination with RL ablation (LA roof ablation [LARA]-1: 59 patients) or (2) PV isolation (LARA-2: 61 patients). Follow-up was performed at 1, 3, and 6 months after the procedure and every 6 months thereafter. After a 3-month blanking period, recurrence was defined as the ocurrence of any atrial tachyarrhythmia lasting ≥30 seconds. PV isolation was achieved in 89% and complete RL block in 81%. RF duration, fluoroscopy, and procedural times were slightly, but not significantly, longer in the LARA-1 group. After 15±10 months, there was no difference in the arrhythmia-free survival after a single AF ablation procedure (LARA-1: 59% vs. LARA-2: 56% at 12 months; log rank P=0.77). The achievement of complete RL block did not influence the results. The incidence of LA macroreentrant tachycardias was 5.1% in the LARA-1 group (n=3) versus 8.2% in the LARA-2 (n=5) (P=ns). Univariate analysis only identified AF duration as a covariate associated with arrhythmia recurrence (hazard ratio, 1.01 [95% confidence interval, 1.002 to 1.012]; P<0.01). CONCLUSION: The linear block at the LA roof is not associated with an improved clinical outcome compared with PV isolation alone. CLINICAL TRIAL REGISTRATION URL: ClinicalTrials.gov. Unique identifier: NCT01203241.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review

  9 / 156437 MEDLINE  
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[PMID]: 25073867
[Au] Autor:Ferro JM; Canhão P
[Ad] Address:Department of Neurosciences, Serviço de Neurologia, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, University of Lisbon, Av. Prof. Egas Moniz, 1649-035, Lisbon, Portugal, jmferro@fm.ul.pt.
[Ti] Title:Cerebral venous sinus thrombosis: update on diagnosis and management.
[So] Source:Curr Cardiol Rep;16(9):523, 2014 Sep.
[Is] ISSN:1534-3170
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Cerebral venous thrombosis (CVT) is less frequent than ischemic stroke or intracerebral haemorrhage. Its incidence is comparable to that of acute bacterial meningitis in adults. Because of the increased use of magnetic resonance imaging (MR) for investigating patients with acute and subacute headaches and new onset seizures, CVT are now being diagnosed with increasing frequency. CVT have a more varied clinical presentation than other stroke types as they rarely present as a stroke syndrome. Their most frequent presentations are isolated headache, intracranial hypertension syndrome, seizures, a focal lobar syndrome and encephalopathy. The confirmation of the diagnosis of CVT relies on the demonstration of thrombi in the cerebral veins and/or sinuses by MR/MR venography or veno CT. The more frequent risk factors for CVT are prothrombotic conditions, either genetic or acquired, oral contraceptives, puerperium and pregnancy, infection and malignancy. The prognosis of CVT is in general favourable, as only around 15% of the patients remain dependent or die. The main intervention in the acute is anticoagulation with either low molecular weight or unfractionated heparin. In patients in severe condition on admission or who deteriorate despite anticoagulation, local thrombolysis or thrombectomy is an option. Decompressive surgery is life-saving in patients with large venous infarcts or haemorrhage. After the acute phase patients remain anticoagulated for a variable period of time, depending on their inherent thrombotic risk. CVT patients may experience recurrent seizures. Prophylaxis with antiepileptics is recommended after the first seizures, in particular in those with hemispheric lesions. There are several ongoing multicentre registries sand trials which will improve evidence-based management of CVT in the near future.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1007/s11886-014-0523-2

  10 / 156437 MEDLINE  
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[PMID]: 25064114
[Au] Autor:Hoffman RM
[Ad] Address:AntiCancer, Inc., 7917 Ostrow Street, San Diego, CA, 92111, USA, all@anticancer.com.
[Ti] Title:Transgenic nude mice ubiquitously expressing fluorescent proteins for color-coded imaging of the tumor microenvironment.
[So] Source:Methods Mol Biol;1194:353-65, 2014.
[Is] ISSN:1940-6029
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:We have developed a transgenic green fluorescent protein (GFP) nude mouse with ubiquitous GFP expression. The GFP nude mouse was obtained by crossing nontransgenic nude mice with the transgenic C57/B6 mouse in which the ß-actin promoter drives GFP expression in essentially all tissues. In the adult mice, many organs brightly expressed GFP, including the spleen, heart, lungs, spleen, pancreas, esophagus, stomach, and duodenum as well as the circulatory system. The liver expressed GFP at a lesser level. The red fluorescent protein (RFP) transgenic nude mouse was obtained by crossing non-transgenic nude mice with the transgenic C57/B6 mouse in which the beta-actin promoter drives RFP (DsRed2) expression in essentially all tissues. In the RFP nude mouse, the organs all brightly expressed RFP, including the heart, lungs, spleen, pancreas, esophagus, stomach, liver, duodenum, the male and female reproductive systems; brain and spinal cord; and the circulatory system, including the heart, and major arteries and veins. The skinned skeleton highly expressed RFP. The bone marrow and spleen cells were also RFP positive. The cyan fluorescent protein (CFP) nude mouse was developed by crossing nontransgenic nude mice with the transgenic CK/ECFP mouse in which the ß-actin promoter drives expression of CFP in almost all tissues. In the CFP nude mice, the pancreas and reproductive organs displayed the strongest fluorescence signals of all internal organs, which vary in intensity. The GFP, RFP, and CFP nude mice when transplanted with cancer cells of another color are powerful models for color-coded imaging of the tumor microenvironment (TME) at the cellular level.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1007/978-1-4939-1215-5_20


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