Database : MEDLINE
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[PMID]: 25834665
[Au] Autor:Adhikari S; Zeger W
[Ad] Address:University of Arizona Medical Center, Department of Emergency Medicine, Tucson, Arizona.
[Ti] Title:Non-thrombotic Abnormalities on Lower Extremity Venous Duplex Ultrasound Examinations.
[So] Source:West J Emerg Med;16(2):250-4, 2015 Mar.
[Is] ISSN:1936-9018
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Emergency physician-performed compression ultrasonography focuses primarily on the evaluation of the proximal veins of the lower extremity in patients with suspected deep venous thrombosis (DVT). A detailed sonographic evaluation of lower extremity is not performed. The objective of this study was to determine the prevalence of non-thrombotic findings on comprehensive lower extremity venous duplex ultrasound (US) examinations performed on emergency department (ED) patients. METHODS: We performed a retrospective six-year review of an academic ED's records of adult patients who underwent a comprehensive lower extremity duplex venous US examination for the evaluation of DVT. The entire US report was thoroughly reviewed for non-thrombotic findings. RESULTS: We detected non-thrombotic findings in 263 (11%, 95% CI [9.5-11.9%]) patients. Among the non-thrombotic findings, venous valvular incompetence (81, 30%) was the most frequent, followed by cyst/mass (41, 15%), lymphadenopathy (33, 12%), phlebitis (12, 4.5%), hematoma (8, 3%), cellulitis (1, 0.3%) and other (6, 2.2%). CONCLUSION: In our study, we detected a variety of non-thrombotic abnormalities on comprehensive lower extremity venous duplex US examinations performed on ED patients. Some of these abnormalities could be clinically significant and potentially be detected with point-of-care lower extremity US examinations if the symptomatic region is evaluated. In addition to assessment of the proximal veins for DVT, we recommend sonographic evaluation of the symptomatic area in the lower extremity when performing point-of-care ultrasound examinations to identify non-thrombotic abnormalities that may require immediate intervention or close follow up.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1504
[Cu] Class update date: 150404
[Lr] Last revision date:150404
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.5811/westjem.2014.12.24170

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[PMID]: 25834714
[Au] Autor:Tavalla M; Sabaghan M; Abdizadeh R; Khademvatan S; Rafiei A; Razavi Piranshahi A
[Ad] Address:Department of Medical Parasitology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran ; Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran....
[Ti] Title:Seroprevalence of Toxoplasma gondii and Neospora spp. Infections in Arab Horses, Southwest of Iran.
[So] Source:Jundishapur J Microbiol;8(3):e14939, 2015 Mar.
[Is] ISSN:2008-3645
[Cp] Country of publication:Iran
[La] Language:eng
[Ab] Abstract:BACKGROUND: Because of the economic importance of the Arab race horses and also the role of Toxoplasma gondii and Neospora spp. in abortion and reproductive failure of these animals, we decided to perform this study. OBJECTIVES: We designed this study to investigate the seroprevalence of anti-Toxoplasma gondii and anti-Neospora spp. antibodies in Arab horses from 12 cities of Khuzestan province in southwest of Iran. MATERIALS AND METHODS: From October 2009 to March 2011, a total of 235 blood samples were collected from jugular veins of Arab horses of different ages and genders from 12 cities of Khuzestan province. All the sera were tested for anti-Toxoplasma antibodies using the modified agglutination test (MAT) and the existence of anti-Neospora antibodies were tested using N-MAT for Neospora spp. RESULTS: According to the MAT results, antibodies to T. gondii were found in 114 (48.5%) of 235 sera with titers of 1:20 in 84, 1:40 in 19, 1:80 in four, 1:160 in four, and 1:320 in three horses. According to the N-MAT results, antibodies to Neospora spp. were found in 47 (20%) of 235 sera with titers of 1:40 in 39, 1:80 in five, and 1:160 in three horses. We did not observe any statistically significant differences regarding age groups and genders between seropositive and seronegative horses for Neospora spp. using chi-square (χ(2)) test, but it seemed that anti-Toxoplasma antibodies were more prevalent in older horses (≥ 10 years old). CONCLUSIONS: The results indicated that Arab horses are exposed to these parasites in southwest of Iran. Further research is required to determine the genomic structures of these parasites in Arab horses in southwest of Iran.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1504
[Cu] Class update date: 150404
[Lr] Last revision date:150404
[Da] Date of entry for processing:150402
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.5812/jjm.14939

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[PMID]: 25829883
[Au] Autor:Washco V; Engel L; Smith DL; McCarron R
[Ad] Address:Department of Internal Medicine, Louisiana State University Health Sciences Center, New Orleans, LA....
[Ti] Title:Distended bladder presenting with altered mental status and venous obstruction.
[So] Source:Ochsner J;15(1):70-3, 2015.
[Is] ISSN:1524-5012
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: New onset or acute worsening of bilateral lower extremity swelling is commonly caused by venous congestion from decompensated heart failure, pulmonary disease, liver dysfunction, or kidney insufficiency. A thromboembolic event, lymphatic obstruction, or even external compression of venous flow can also be the culprit. CASE REPORT: We report the case of an 83-year-old male with a history of myelodysplastic syndrome that progressed to acute myeloid leukemia, bipolar disorder, and benign prostatic hypertrophy. He presented with altered mental status and new onset lower extremity edema caused by acute bladder outflow obstruction. Computed tomography of the abdomen and pelvis showed the patient's distended bladder compressing bilateral external iliac veins. CONCLUSION: Insertion of a Foley catheter resulted in several liters of urine output and marked improvement in his lower extremity edema and mental status a few hours later. Our extensive workup failed to reveal a cause of the patient's acute change in mental status, and we attributed it to a concept known as cystocerebral syndrome.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1504
[Cu] Class update date: 150404
[Lr] Last revision date:150404
[Da] Date of entry for processing:150401
[St] Status:PubMed-not-MEDLINE

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[PMID]: 25799244
[Au] Autor:Kayssi A; Pope M; Vucemilo I; Werneck C
[Ad] Address:The Division of Vascular Surgery, Trillium Health Partners, University of Toronto, Mississauga, Ont....
[Ti] Title:Endovenous radiofrequency ablation for the treatment of varicose veins.
[So] Source:Can J Surg;58(2):85-6, 2014 Apr.
[Is] ISSN:1488-2310
[Cp] Country of publication:Canada
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Cu] Class update date: 150404
[Lr] Last revision date:150404
[Js] Journal subset:IM
[St] Status:In-Data-Review

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[PMID]: 25680694
[Au] Autor:Yang X; Shao H; Liu W; Gu W; Shu X; Mo Y; Chen X; Zhang Q; Jiang M
[Ad] Address:Department of Gastroenterology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China....
[Ti] Title:Endoplasmic reticulum stress and oxidative stress are involved in ZnO nanoparticle-induced hepatotoxicity.
[So] Source:Toxicol Lett;234(1):40-9, 2015 Apr 2.
[Is] ISSN:1879-3169
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Zinc oxide nanoparticles (Nano-ZnO) are widely used in sunscreens, clothes, medicine and electronic devices. However, the potential risks of human exposure and the potential for adverse health impacts are not well understood. Previous studies have demonstrated that exposure to Nano-ZnO caused liver damage and hepatocyte apoptosis through oxidative stress, but the molecular mechanisms that are involved in Nano-ZnO-induced hepatotoxicity are still unclear. Endoplasmic reticulum (ER) is sensitive to oxidative stress, and also plays a crucial role in oxidative stress-induced damage. Previous studies showed that ER stress was involved in many chemical-induced liver injuries. We hypothesized that exposure to Nano-ZnO caused oxidative stress and ER stress that were involved in Nano-ZnO-induced liver injury. To test our hypothesis, mice were gavaged with 200mg/kg or 400mg/kg of Nano-ZnO once a day for a period of 90 days, and blood and liver tissues were obtained for study. Our results showed that exposure to Nano-ZnO caused liver injury that was reflected by focal hepatocellular necrosis, congestive dilation of central veins, and significantly increased alanine transaminase (ALT) and aspartate transaminase (AST) levels. Exposure to Nano-ZnO also caused depletion of glutathione (GSH) in the liver tissues. In addition, our electron microscope results showed that ER swelling and ribosomal degranulation were observed in the liver tissues from mice treated with Nano-ZnO. The mRNA expression levels of ER stress-associated genes (grp78, grp94, pdi-3, xbp-1) were also up-regulated in Nano-ZnO-treated mice. Nano-ZnO caused increased phosphorylation of RNA-dependent protein kinase-like ER kinase (PERK) and eukaryotic initiation factor 2α (eIF2α). Finally, we found that exposure to Nano-ZnO caused increased ER stress-associated apoptotic protein levels, such as caspase-3, caspase-9, caspase-12, phosphorylation of JNK, and CHOP/GADD153, and up-regulation of pro-apoptotic genes (chop and bax). These results suggest that oxidative stress and ER stress-induced apoptosis are involved in Nano-ZnO-induced hepatotoxicity in mice.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1502
[Cu] Class update date: 150404
[Lr] Last revision date:150404
[Js] Journal subset:IM
[St] Status:In-Data-Review

  6 / 159165 MEDLINE  
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[PMID]: 23791957
[Au] Autor:Elhammady MS; Heros RC
[Ad] Address:Department of Neurological Surgery, University of Miami School of Medicine, Miami, Florida, USA.
[Ti] Title:Cerebral veins: to sacrifice or not to sacrifice, that is the question.
[So] Source:World Neurosurg;83(3):320-4, 2015 Mar.
[Is] ISSN:1878-8750
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1504
[Js] Journal subset:IM
[St] Status:In-Data-Review

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[PMID]: 25839721
[Au] Autor:Kramer AH
[Ad] Address:Department of Critical Care Medicine and Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Alberta, Canada.
[Ti] Title:Ancillary testing in brain death.
[So] Source:Semin Neurol;35(2):125-38, 2015 Apr.
[Is] ISSN:1098-9021
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Despite worldwide acceptance of the concept of brain death, there is marked variability in the use of ancillary testing. In most countries, ancillary tests are used primarily when confounding factors interfere with reliable completion of a clinical assessment, or physiologic instability precludes performance of an apnea test. Alternatively, in some countries, confirmatory ancillary tests are routinely required before brain death can be diagnosed. Ancillary tests assess brain function (e.g., electroencephalography) or blood flow (e.g., cerebral angiography). Evaluation of blood flow is affected less by confounding clinical factors and is now preferred in most jurisdictions. With angiographic techniques, a significant proportion of patients meeting clinical criteria for brain death have some opacification of proximal intracranial arteries. Consequently, the sensitivity of angiography is strongly influenced by the particular criteria that are used to define intracranial circulatory arrest. Lack of enhancement of the great cerebral and internal cerebral veins has the highest sensitivity. Worldwide experience with newer tests, such as computed tomography and magnetic resonance angiography, is growing. Radionuclide imaging has the advantage of not requiring use of potentially nephrotoxic contrast material. Transcranial Doppler ultrasonography can be brought to the bedside to demonstrate lack of brain blood flow. The specificity of imaging techniques in the detection of intracranial circulatory arrest has not been as well studied as their sensitivity.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1504
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1055/s-0035-1547541

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[PMID]: 25591128
[Au] Autor:Thierfelder KM; Havla L; Beyer SE; Ertl-Wagner B; Meinel FG; von Baumgarten L; Janssen H; Ditt H; Reiser MF; Sommer WH
[Ad] Address:From the *Institute for Clinical Radiology, Josef Lissner Laboratory for Biomedical Imaging, Institute for Clinical Radiology, Departments of Neurology, and Neuroradiology, Ludwig Maximilians University Hospital Munich; and ∥Siemens AG, Healthcare Sector, Erlangen, Germany.
[Ti] Title:Color-coded cerebral computed tomographic angiography: implementation of a convolution-based algorithm and first clinical evaluation in patients with acute ischemic stroke.
[So] Source:Invest Radiol;50(5):361-5, 2015 May.
[Is] ISSN:1536-0210
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: The objective of this study was to develop a new method of displaying dynamic cerebral computed tomographic (CT) angiography (CTA) data sets in which the time delay to maximum enhancement (Tdelay) is displayed in a range of colors (color-coded CT angiography [cCTA]). MATERIALS AND METHODS: This institutional review board-approved study included multiparametric CT data sets from 16 patients with different types of supra-aortic large vessel occlusions. Color-coded CT angiography was reconstructed from CT perfusion raw data sets. All voxel enhancement curves were fitted to f(t) = α AIFmtt(t - Δt), with AIFmtt(t), indicating enhancement of AIF dilated by convolution with boxcar function (with mean transit time [mtt]); α, scaling factor; and [INCREMENT]t, transition along the time. The time delay to maximum enhancement was defined as Tdelay = Δt +0.5 mtt. Values of Tdelay were color-coded and superimposed on temporal maximum intensity projections CTA resulting in colored angiographic composite images. For a pilot clinical evaluation, diagnostic confidence in determining the pathology, quality of the visualization of leptomeningeal collaterals, and additional diagnostic information were assessed. RESULTS: The reconstruction of cCTA was technically feasible in all 16 patients. Both diagnostic confidence (P < 0.01) and the quality of the visualization of collaterals (P < 0.0001) were significantly higher when using the combination of single-phase CTA and cCTA compared with single-phase CTA alone. Additional diagnostic information was obtained with cCTA regarding occlusion type (reader 1: 5 cases and reader 2: 4 cases), differentiation between arteries and veins (11/13), differentiation between antegrade and retrograde filling (12/13), as well as leptomeningeal collateralization (13/14). CONCLUSIONS: Color-coded CT angiography is a technically feasible technique that provides additional information on cerebral hemodynamics in ischemic stroke patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1504
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1097/RLI.0000000000000134

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[PMID]: 25840374
[Au] Autor:Mayer DK
[Ti] Title:40 years and counting.
[So] Source:Clin J Oncol Nurs;19(2):131-2, 2015 Apr 1.
[Is] ISSN:1538-067X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:I find it hard to believe that the Oncology Nursing Society (ONS) and my career in oncology nursing are 40 years old when many of our members are not even 40 years old! So much has changed in that time to make cancer care better. In 1975, the year that ONS became incorporated, the five-year survival rate was 49% (up from 35% in 1950). By 2010, the rate increased to 68% (American Cancer Society, 2015). However, not everyone benefited equally because a gap existed in the survival rates between Caucasians and African Americans; while that gap has narrowed, it has not disappeared. In 1975, about two dozen drugs were approved by the U.S. Food and Drug Administration (FDA) to treat cancer (Devita & Chu, 2008). During the past 15 years, 127 new agents were approved (Centerwatch, 2015), with another 771 new medicines and vaccines currently in clinical trials or awaiting review by the FDA (Pharmaceutical Research and Manufacturers of America, 2015). The first Hickman catheters, and later ports, were introduced in the late 1970s (Bjeletich & Hickman, 1980), and I remember introducing the Hickman at my institution to help keep our patients' veins patent-it was a godsend. We now have so many more options in venous access devices. Cancer care became increasingly more complex in our understanding of the disease, its treatment, and in the supportive care needs of patients during that time period. But our goals were always the same: to help our patients and their families deal with this life-altering disease and to reduce the burden of their journey.
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[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1504
[Js] Journal subset:N
[St] Status:In-Data-Review
[do] DOI:10.1188/15.CJON.131-132

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[PMID]: 25840104
[Au] Autor:Doucet KM; Labinaz M; Chandy G; Mielniczuk L; Stewart D; Contreras-Dominguez V; Pugliese C; Dennie C; Burwash IG; Davies RA
[Ad] Address:Divisions of Cardiology and Nursing, University of Ottawa, Ottawa, Ontario, Canada....
[Ti] Title:Pulmonary Hypertension due to Fibrosing Mediastinitis Treated Successfully With Stenting of Pulmonary VeinStenoses.
[So] Source:Can J Cardiol;31(4):548.e5-7, 2015 Apr.
[Is] ISSN:1916-7075
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:We describe a patient with fibrosing mediastinitis after childhood histoplasmosis who presented with severe pulmonary hypertension secondary to pulmonary vein stenoses. Stenting of 2 stenosed pulmonary veins via a transseptal approach resulted in an immediate decrease in systolic pulmonary artery pressure from 90 to 68 mm Hg and improvement in dyspnea and cardiac index, which was sustained at 6 months. This case highlights the importance of routinely assessing the pulmonary veins during workup for pulmonary hypertension.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1504
[Js] Journal subset:IM
[St] Status:In-Data-Review


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