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[PMID]: 26253536
[Au] Autor:Koltowska K; Paterson S; Bower NI; Baillie GJ; Lagendijk AK; Astin JW; Chen H; Francois M; Crosier PS; Taft RJ; Simons C; Smith KA; Hogan BM
[Ad] Address:Division of Genomics of Development and Disease, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia;...
[Ti] Title:mafba is a downstream transcriptional effector of Vegfc signaling essential for embryonic lymphangiogenesis in zebrafish.
[So] Source:Genes Dev;29(15):1618-30, 2015 Aug 1.
[Is] ISSN:1549-5477
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The lymphatic vasculature plays roles in tissue fluid balance, immune cell trafficking, fatty acid absorption, cancer metastasis, and cardiovascular disease. Lymphatic vessels form by lymphangiogenesis, the sprouting of new lymphatics from pre-existing vessels, in both development and disease contexts. The apical signaling pathway in lymphangiogenesis is the VEGFC/VEGFR3 pathway, yet how signaling controls cellular transcriptional output remains unknown. We used a forward genetic screen in zebrafish to identify the transcription factor mafba as essential for lymphatic vessel development. We found that mafba is required for the migration of lymphatic precursors after their initial sprouting from the posterior cardinal vein. mafba expression is enriched in sprouts emerging from veins, and we show that mafba functions cell-autonomously during lymphatic vessel development. Mechanistically, Vegfc signaling increases mafba expression to control downstream transcription, and this regulatory relationship is dependent on the activity of SoxF transcription factors, which are essential for mafba expression in venous endothelium. Here we identify an indispensable Vegfc-SoxF-Mafba pathway in lymphatic development.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1508
[Cu] Class update date: 150822
[Lr] Last revision date:150822
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1101/gad.263210.115

  2 / 161255 MEDLINE  
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[PMID]: 25376026
[Au] Autor:Kayaalp C; Abbasov P; Sabuncuoglu MZ; Alam AH; Yilmaz S
[Ad] Address:>From the Liver Transplantation Institute, Inonu University, Malatya, Turkey.
[Ti] Title:Peritoneal Patch for an Occluded Venous Conduit of a Right Lobe During a Living-Donor Liver Transplant.
[So] Source:Exp Clin Transplant;13(4):365-8, 2015 Aug.
[Is] ISSN:2146-8427
[Cp] Country of publication:Turkey
[La] Language:eng
[Ab] Abstract:Drainage of segments V and VIII venous tributaries usually is mandatory to avoid congestion of the anterior segment of right lobe during a living-donor liver transplant. Extension of the venous tributaries to the vena cava can be done with several vascular materials. Here, we describe using an 8 × 3 cm vascular patch from the peritoneum over the venous conduit (which had become kinked) that drained segments V and VIII veins. Peritoneal reconstruction worked well during the early postoperative period and avoided congestion of the right anterior liver segment. During the late postoperative period, the conduit became occluded as do other grafts used to extend tributaries; however, the collaterals that developed prevented congestion of the anterior liver segment. Using part of the peritoneum as a venous graft during living-donor liver transplant can be a good alternative to the other vascular grafting options. Peritoneal grafting provides temporary drainage of the liver lobe, prevents congestion of the anterior section, and saves time creating venous collaterals.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1508
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.6002/ect.2013.0266

  3 / 161255 MEDLINE  
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[PMID]: 26288608
[Au] Autor:Glowka TR; Kalff JC; Schäfer N
[Ad] Address:Department of Surgery, University of Bonn, Bonn, Germany.
[Ti] Title:Clinical Management of Chronic Portal/Mesenteric Vein Thrombosis: The Surgeon's Point of View.
[So] Source:Viszeralmedizin;30(6):409-15, 2014 Dec.
[Is] ISSN:1662-6664
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:BACKGROUND: Bleeding from esophageal varices is a life-threatening complication of chronic portal hypertension (PH), occuring in 15% of patients with a mortality rate between 20 and 35%. METHODS: Based on a literature review and personal experience in the therapy of PH, we recommend a therapy strategy for the secondary prophylaxis of variceal bleeding in PH. RESULTS: The main causes for PH in western countries are alcoholic/viral liver cirrhosis and extrahepatic portal/mesenteric vein occlusion, mainly caused by myeloproliferative neoplasms or hypercoagulability syndromes. The primary therapy is medical; however, when recurrent bleeding occurs, a definitive therapy is required. In the case of parenchymal decompensation, liver transplantation is the causal therapy, but in case of good hepatic reserve or without underlying liver disease, a portal decompressive therapy is necessary. Transjugular intrahepatic portosystemic shunt has achieved a widespread acceptance, although evidence is comparable with or better for surgical shunting procedures in patients with good liver function. The type of surgical shunt should be chosen depending on the patent veins of the portovenous system and the personal expertise. CONCLUSION: The therapy decision should be based on liver function, morphology of the portovenous system, and imminent liver transplantation and should be made by an interdisciplinary team of gastroenterologists, interventional radiologists, and visceral surgeons.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1508
[Cu] Class update date: 150821
[Lr] Last revision date:150821
[Da] Date of entry for processing:150820
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1159/000369575

  4 / 161255 MEDLINE  
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[PMID]: 26288516
[Au] Autor:Arabi M; Krishnamurthy V; Cwikiel W; Vellody R; Wakefield TW; Rectenwald J; Williams D
[Ad] Address:Department of Radiology, University of Michigan Health System, Ann Arbor, Michigan, USA....
[Ti] Title:Endovascular treatment of thrombosed inferior vena cava filters: Techniques and short-term outcomes.
[So] Source:Indian J Radiol Imaging;25(3):233-8, 2015 Jul-Sep.
[Is] ISSN:0971-3026
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:PURPOSE: To present the techniques for endovascular treatment of thrombosed filter-bearing inferior vena cavae (IVCs), along with short-term clinical and imaging follow-up. MATERIALS AND METHODS: A total of 45 consecutive patients (17 females and 28 males), aged 19-79 years (mean age of 49 years), who had IVC filter placement complicated by symptomatic acute or chronic iliocaval thrombosis and underwent endovascular therapy were studied. All patients presented with lower extremity swelling and/or pain. One patient also had bilateral lower extremity swelling and chronic gastrointestinal (GI) bleeding which was secondary to chronic systemic to portal venous collaterals. Patients underwent one or more of the following endovascular treatments depending on the chronicity and extent of thrombosis: (a) catheter-directed thrombolysis (CDT) (n = 25), (b) pharmacomechanical thrombolysis (PMT) (n = 15), (c) balloon angioplasty (n = 45), and/or (d) stent placement across the filter (n = 42). In addition, 16 patients underwent groin arteriovenous fistula (AVF) creation (36%) and 3 (7%) had femoral venous thrombectomy to improve flow in the recanalized iliac veins and IVCs. RESULTS: Anatomical success was achieved in all patients. Follow-up was not available in 10 patients (lost to follow-up, n = 4; expired due to comorbidities, n = 2; lost to follow-up after re-intervention, n = 4). At a mean follow-up time of 13.3 months (range 1-48 months), clinical success was achieved in 27 patients (60%), i.e. in 21 patients without re-intervention and in 6 patients with re-intervention. Clinical success was not achieved despite re-intervention in eight patients. Higher clinical success was noted in patients who did not require repeat interventions (P = 0.03) and the time to re-intervention was significantly shorter in patients who had clinical failure (P = 0.01). AVF creation did not improve the clinical success rate (P = 1). There was no significant difference in clinical success between patients who had acute or subacute thrombosis compared to those who had chronically occluded filter-bearing IVCs (P = 1). CONCLUSION: This study suggests that endovascular therapy for thrombosed filter-bearing IVCs is safe and technically feasible.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1508
[Cu] Class update date: 150821
[Lr] Last revision date:150821
[Da] Date of entry for processing:150820
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.4103/0971-3026.161436

  5 / 161255 MEDLINE  
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[PMID]: 26288449
[Au] Autor:Ibarguren AM; Ramos JG; Merino MB; Pedrero RM; Fernández CG; Pinto PH
[Ad] Address:Department of Dermatology, La Paz Hospital, Madrid, Spain....
[Ti] Title:Vascular Tumor on the Forehead of an HIV Patient.
[So] Source:Indian J Dermatol;60(4):423, 2015 Jul-Aug.
[Is] ISSN:1998-3611
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:Cirsoid aneurysm is a small vascular proliferation characterized by small to medium-sized channels with features of arteries and veins, that present as small, blue or red asymptomatic papule. We report a case of a crisoid aneurysm on the forhead of an HIV patient that suggested a Kaposi sarcoma as a differential diagnosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1508
[Cu] Class update date: 150821
[Lr] Last revision date:150821
[Da] Date of entry for processing:150820
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.4103/0019-5154.160536

  6 / 161255 MEDLINE  
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[PMID]: 25079610
[Au] Autor:Hadjiiski L; Zhou C; Chan HP; Chughtai A; Agarwal P; Kuriakose J; Kazerooni E; Wei J; Patel S
[Ad] Address:Department of Radiology, University of Michigan, Ann Arbor, MI 48109, USA.
[Ti] Title:Coronary CT angiography (cCTA): automated registration of coronary arterial trees from multiple phases.
[So] Source:Phys Med Biol;59(16):4661-80, 2014 Aug 21.
[Is] ISSN:1361-6560
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Coronary computed tomography angiography (cCTA) is a commonly used imaging modality for the evaluation of coronary artery disease. cCTA is generally reconstructed in multiple cardiac phases because different coronary arteries may be better visualized in some phases than in others due to the periodic cardiac motion. We are developing an automated registration method for coronary arterial trees from multiple-phase cCTA that has potential application in building a 'best-quality' tree to facilitate image analysis and detection of stenotic plaques. Given the segmented left or right coronary arterial (LCA or RCA) trees from the multiple phases as input, the adjacent phase pairs, where displacements are relatively small, are registered by a specifically designed method based on a cubic B-spline with fast localized optimization (CBSO). For the phase pairs with large displacements, a global registration using an affine transform with quadratic terms and nonlinear simplex optimization (AQSO) is followed by a local registration using CBSO to refine the AQSO registered volumes. 26 LCA and 26 RCA trees with six cCTA phases from 26 patients were used for registration evaluation. The average distances for the tree pairs between the adjacent phases with small displacements before and after CBSO registration were 0.96  ±  0.79 and 0.76  ±  0.61 mm respectively for LCA, and 0.93  ±  0.97 and 0.64  ±  0.43 mm, respectively for RCA. The average distance differences before and after registration were statistically significant (p < 0.001) for both LCA and RCA trees. The average distances for the distant phases with large displacements before registration, after AQSO registration, and finally after the CBSO registration were 2.85  ±  1.46, 1.62  ±  0.76, and 0.97  ±  0.43 mm, respectively for LCA, and 4.03  ±  2.36, 2.18  ±  1.11, and 0.97  ±  0.44 mm, respectively for RCA. The average distance differences between every two consecutive stages of registration were statistically significant. The corresponding phases of LCA and RCA trees were aligned to an average of less than 1 mm, providing a basis for a best-quality tree construction.
[Mh] MeSH terms primary: Coronary Angiography/methods
Coronary Vessels/radiography
Image Processing, Computer-Assisted/methods
Tomography, X-Ray Computed/methods
[Mh] MeSH terms secundary: Automation
Electrocardiography
Humans
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Entry month:1503
[Cu] Class update date: 150821
[Lr] Last revision date:150821
[Js] Journal subset:IM
[Da] Date of entry for processing:140804
[St] Status:MEDLINE
[do] DOI:10.1088/0031-9155/59/16/4661

  7 / 161255 MEDLINE  
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[PMID]: 26264228
[Au] Autor:Shen Y; Zhuang X; Xiao P; Dai W; Li Q
[Ad] Address:Graduate School, Guangxi Medical University, 22# Shuang Yong Road, Nanning, 530021, China. hktksy@yahoo.com....
[Ti] Title:Oesophagectomy in a patient with azygos vein continuation of the inferior vena cava: report of a case.
[So] Source:World J Surg Oncol;13(1):242, 2015.
[Is] ISSN:1477-7819
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The azygos system of veins varies greatly in its mode of origin, but the variation in which the azygos vein is a continuation of the inferior vena cava (IVC) is rare. During an oesophagectomy, the azygos vein typically is transected as a requirement of the surgery. In this case, the enlarged azygos and its arch were a continuation of the IVC. During our procedure, we first established a bypass between the right femoral vein and the jugular vein in case of injury to the azygos vein, and we then performed a McKeown oesophagectomy without transecting the azygos vein. Our experience suggests that an oesophagectomy in cases with an azygos vein continuation of the IVC is feasible. An adequate medical examination and careful reading of the imaging is crucial for the safety of these surgical procedures. An appropriate surgical approach should be selected according to the location of the tumour, the size of the tumour and its anatomical features. The establishment of a veno-venous bypass and protection of the azygos arch in patients whose azygos vein is a continuation of IVC is necessary.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1508
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1186/s12957-015-0625-3

  8 / 161255 MEDLINE  
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[PMID]: 25547041
[Au] Autor:Ohno K; Saito Y; Togawa M; Shinohara Y; Ito T; Sugano H; Itamura S; Nishimura Y; Tamasaki A; Maegaki Y
[Ad] Address:Division of Child Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Japan. Electronic address: oonok@med.tottori-u.ac.jp....
[Ti] Title:Evolution of a symptomatic diffuse developmental venous anomaly with progressive cerebral atrophy in an atypical case of Sturge-Weber syndrome.
[So] Source:Brain Dev;37(8):817-21, 2015 Sep.
[Is] ISSN:1872-7131
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:A 2-year-old boy had glaucoma, bilateral facial haemangioma and widespread blue nevi on the trunk and extremities since birth. Dilated medullary veins were detected in the left cerebral periventricular white matter on magnetic resonance imaging (MRI). Macrocephaly and delayed psychomotor development were observed during late infancy, and susceptibility-weighted angiography revealed an extensive developmental venous anomaly with multiple caput medusae throughout bilateral hemispheres, accompanied by periventricular hyperintense alterations on MRI and progressive diffuse atrophy of the cerebral mantle with left-sided predominance. Hypoperfusion in the left cerebral and cerebellar hemisphere was also uncovered. No meningeal haemangioma was observed. This patient may represent a novel subgroup of phakomatosis cases that can be regarded as a variant of Sturge-Weber syndrome.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1508
[Js] Journal subset:IM
[St] Status:In-Data-Review

  9 / 161255 MEDLINE  
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[PMID]: 26292260
[Au] Autor:Rajabi H; Ghoroubi N; Darvizeh A; Dirks JH; Appel E; Gorb SN
[Ad] Address:Institute of Zoology, Functional Morphology and Biomechanics, Kiel University, Kiel, Germany. Department of Mechanical Engineering, The University of Guilan, Rasht, Iran.
[Ti] Title:A comparative study of the effects of vein-joints on the mechanical behaviour of insect wings: I. Single joints.
[So] Source:Bioinspir Biomim;10(5):056003, 2015.
[Is] ISSN:1748-3190
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The flight performance of insects is strongly affected by the deformation of the wing during a stroke cycle. Many insects therefore use both active and passive mechanisms to control the deformation of their wings in flight. Several studies have focused on the wing kinematics, and plenty is known about the mechanism of their passive deformability. However, given the small size of the vein-joints, accurate direct mechanical experiments are almost impossible to perform. We therefore developed numerical models to perform a comparative and comprehensive investigation of the mechanical behaviour of the vein-joints under external loading conditions. The results illustrate the effect of the geometry and the presence of the rubberlike protein resilin on the flexibility of the joints. Our simulations further show the contribution of the spikes to the anisotropic flexural stiffness in the dorsal and ventral directions. In addition, our results show that the cross veins, only in one joint type, help to transfer the stress to the thicker longitudinal veins. The deformation pattern and the stress distribution in each vein-joint are discussed in detail. This study provides a strong background for further realistic modelling of the dragonfly wing deformation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1508
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1088/1748-3190/10/5/056003

  10 / 161255 MEDLINE  
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[PMID]: 26092100
[Au] Autor:McKean JS; Murray F; Gibson G; Shewan DA; Tucker SJ; Nixon GF
[Ad] Address:School of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK....
[Ti] Title:The cAMP-producing agonist beraprost inhibits human vascular smooth muscle cell migration via exchange protein directly activated by cAMP.
[So] Source:Cardiovasc Res;107(4):546-55, 2015 Sep 1.
[Is] ISSN:1755-3245
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:AIMS: During restenosis, vascular smooth muscle cells (VSMCs) migrate from the vascular media to the developing neointima. Preventing VSMC migration is therefore a therapeutic target for restenosis. Drugs, such as prostacyclin analogues, that increase the intracellular concentration of cyclic adenosine monophosphate (cAMP) can inhibit VSMC migration, but the mechanisms via which this occurs are unknown. Two main downstream mediators of cAMP are protein kinase A (PKA) and exchange protein directly activated by cAMP (Epac). This study has examined the effects of the prostacyclin analogue beraprost on VSMC migration and investigated the intracellular pathways involved. METHODS AND RESULTS: In a chemotaxis chamber, human saphenous vein VSMC migrated towards a platelet-derived growth-factor-BB (PDGF) chemogradient. Incubation with therapeutically relevant concentrations of cAMP-producing agonist beraprost significantly decreased PDGF-induced migration. Direct activation of either PKA or Epac inhibited migration whereas inhibition of PKA did not prevent the anti-migratory effect of beraprost. Direct activation of Epac also prevented hyperplasia in ex vivo serum-treated human veins. Using fluorescence resonance energy transfer, we demonstrated that beraprost activated Epac but not PKA. The mechanisms of this Epac-mediated effect involved activation of Rap1 with subsequent inhibition of RhoA. Cytoskeletal rearrangement at the leading edge of the cell was consequently inhibited. Interestingly, Epac1 was localized to the leading edge of migrating VSMC. CONCLUSIONS: These results indicate that therapeutically relevant concentrations of beraprost can inhibit VSMC migration via a previously unknown mechanism involving the cAMP mediator Epac. This may provide a novel target that could blunt neointimal formation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1508
[Cu] Class update date: 150820
[Lr] Last revision date:150820
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1093/cvr/cvv176


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