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[PMID]: 25317217
[Au] Autor:Kremmer S; Iliadou M; Anastassiou G; Schallenberg M; Vilser W; Steuhl KP; Selbach JM
[Ad] Address:Department of Ophthalmology, Evangelische Kliniken Gelsenkirchen, Munckelstr. 27, 45879 Gelsenkirchen, Germany ; Department of Ophthalmology, University of Duisburg-Essen, Hufelandstr. 55, 45122 Essen, Germany....
[Ti] Title:Influence of latanoprost on retinal microcirculation in glaucoma.
[So] Source:Open Ophthalmol J;8:60-6, 2014.
[Is] ISSN:1874-3641
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:PURPOSE: To test whether latanoprost has an influence on ocular haemodynamics, considering the general reputation of prostaglandins which is frequently associated with vasoconstriction. The effect of latanoprost on the retinal blood supply of treatment-naïve glaucoma patients was tested. MATERIALS AND METHODOLOGY: 13 patients (7 male, 6 female) who had just recently been diagnosed with primary open-angle glaucoma (POAG) were treated with latanoprost (0.005%). The average age of our study group was 63.8 years (+/- 2.9 years). The drug's effect on retinal autoregulation was assessed by flicker test using the Dynamic Vessel Analyzer (DVA). Examinations took place before initializing treatment, after 4 weeks and once again after 4 to 6 months. RESULTS: In our group of POAG patients, the IOP under treatment was significantly reduced about 25%. No intraindividual differences in systemic blood pressure and heart rate were observed. In DVA measurements of glaucoma patients, the maximum flicker dilation of the arteries was significantly lower than reported for healthy volunteers. Beyond that, POAG patients did not show significant differences in vessel diameters, peak amplitudes as well as maximum dilations of retinal arteries and veins before and under treatment with latanoprost (0.005%). CONCLUSION: Latanoprost markedly lowered the IOP but it did not exert a significant effect on retinal haemodynamics. There was neither a tendency towards vasoconstriction nor towards vasodilation. Sustaining reperfusion damage after topical latanoprost therapy thus seems to be highly unlikely. Further studies must show if sole IOP lowering or a dual positive effect - IOP lowering and improvement of retinal vessel autoregulation - have a more positive impact on the long term follow-up of glaucoma patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1410
[Cu] Class update date: 141018
[Lr] Last revision date:141018
[Da] Date of entry for processing:141015
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.2174/1874364101408010060

  2 / 157035 MEDLINE  
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[PMID]: 25317335
[Au] Autor:Wiegering V; Schmid S; Andres O; Wirth C; Wiegering A; Meyer T; Winkler B; Schlegel PG; Eyrich M
[Ad] Address:Department of Pediatric Hematology/Oncology and Stem Cell Transplantation, University Children's Hospital, D31, Josef-Schneider-Straße 2, D-97080 Würzburg, Germany....
[Ti] Title:Thrombosis as a complication of central venous access in pediatric patients with malignancies: a 5-year single-center experience.
[So] Source:BMC Hematol;14(1):18, 2014.
[Is] ISSN:2052-1839
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Reliable central venous access (CVC) is essential for hematology-oncology patients since frequent puncture of peripheral veins-e.g., for chemotherapy, antibiotic administration, repeated blood sampling, and monitoring-can cause unacceptable pain and psychological trauma, as well as severe side effects in cases of extravasation of chemotherapy drugs. However, CVC lines still carry major risk factors, including thrombosis, infection (e.g., entry site, tunnel, and luminal infections), and catheter dislocation, leakage, or breakage. METHODS: Here we performed a retrospective database analysis to determine the incidence of CVC-associated thrombosis in a single-center cohort of 448 pediatric oncologic patients, and to analyze whether any subgroup of patients was at increased risk and thus might benefit from prophylactic anticoagulation. RESULTS: Of the 448 patients, 269 consecutive patients received a CVC, and 55 of these 269 patients (20%) also had a thrombosis. Of these 55 patients, 43 had at least one CVC-associated thrombosis (total number of CVC-associated thrombosis: n = 52). Among all patients, the median duration of CVC exposure was 464 days. Regarding exposure time, no significant difference was found between patients with and without CVC-associated thrombosis. Subclavia catheters and advanced tumor stages seem to be the main risk factors for the development of CVC-associated thrombosis, whereas pharmacologic prophylaxis did not seem to have a relevant impact on the rate of thrombosis. CONCLUSIONS: We conclude that pediatric surgeons and oncologists should pay close attention to ensuring optimal and accurate CVC placement, as this appears the most effective tool to minimize CVC-associated complications.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1410
[Cu] Class update date: 141018
[Lr] Last revision date:141018
[Da] Date of entry for processing:141015
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1186/2052-1839-14-18

  3 / 157035 MEDLINE  
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[PMID]: 24723557
[Au] Autor:Andia ME; Saha P; Jenkins J; Modarai B; Wiethoff AJ; Phinikaridou A; Grover SP; Patel AS; Schaeffter T; Smith A; Botnar RM
[Ad] Address:From the Division of Imaging Sciences and Biomedical Engineering, School of Medicine, St Thomas' Hospital, King's College London, London, United Kingdom (M.E.A., A.J.W., A.P., T.S., R.M.B.); Academic Department of Surgery, Cardiovascular Division (P.S., J.J., B.M., S.P.G., A.S.P., A.S.), Wellcome Tr...
[Ti] Title:Fibrin-targeted magnetic resonance imaging allows in vivo quantification of thrombus fibrin content and identifies thrombi amenable for thrombolysis.
[So] Source:Arterioscler Thromb Vasc Biol;34(6):1193-8, 2014 Jun.
[Is] ISSN:1524-4636
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Deep venous thrombosis is a major health problem. Thrombolytic therapies are effective in recanalizing the veins and preventing post-thrombotic complications, but there is no consensus on selection criteria. The aim of this study was to investigate a fibrin-specific MRI contrast agent (EP-2104R) for the accurate quantification of thrombus' fibrin content in vivo and for the identification of thrombus suitable for thrombolysis. APPROACH AND RESULTS: Venous thrombosis was induced in the inferior vena cava of 8- to 10-week-old male BALB/C mice and MRI performed 2, 4, 7, 10, 14, and 21 days later. Eighteen mice were scanned at each time point pre and 2 hours post injection of EP-2104R (8.0 µmol/kg) with 12 mice at each time point used to correlate fibrin contrast uptake with thrombus' histological stage and fibrin content. Six mice at each time point were immediately subjected to intravascular thrombolytic therapy (10 mg/kg of tissue-type plasminogen activator). Mice were imaged to assess response to lytic therapy 24 hours after thrombolytic treatment. Two mice at each time point were scanned post injection of 0.2 mmol/kg of Gd-DTPA (gadolinium with diethylenetriaminepentacetate, Magnevist, Schering AG, Berlin, Germany) for control purpose. Contrast uptake was correlated positively with the fibrin content of the thrombus measured by Western blotting (R(2)=0.889; P<0.001). Thrombus relaxation rate (R1) post contrast and the change in visualized thrombus size on late gadolinium enhancement inversion recovery MRI pre-EP-2104R and post-EP-2104R injection were the best predictors for successful thrombolysis (area under the curve, 0.989 [95% confidence interval, 0.97-1.00] and 0.994 [95% confidence interval, 0.98-1.00] respectively). CONCLUSIONS: MRI with a fibrin-specific contrast agent accurately estimates thrombus fibrin content in vivo and identifies thrombi that are amenable for thrombolysis.
[Mh] MeSH terms primary: Fibrin/analysis
Magnetic Resonance Imaging/methods
Thrombolytic Therapy
Venous Thrombosis/diagnosis
[Mh] MeSH terms secundary: Animals
Gadolinium/diagnostic use
Male
Mice
Mice, Inbred BALB C
Peptides/diagnostic use
Venous Thrombosis/drug therapy
Venous Thrombosis/metabolism
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (EP-2104R); 0 (Peptides); 9001-31-4 (Fibrin); AU0V1LM3JT (Gadolinium)
[Em] Entry month:1407
[Cu] Class update date: 141018
[Lr] Last revision date:141018
[Js] Journal subset:IM
[Da] Date of entry for processing:140515
[St] Status:MEDLINE
[do] DOI:10.1161/ATVBAHA.113.302931

  4 / 157035 MEDLINE  
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[PMID]: 24036578
[Au] Autor:Kimura S; Kotani A; Takimoto T; Yoshino A; Katayama Y
[Ad] Address:Division of Neurosurgery, Department of Neurological Surgery, Nihon University School of Medicine, 30-1 Oyaguchi Kami-cho, Itabashi-ku, Tokyo, 173-8610, Japan, kimura.shigeyoshi._@ja3.so-net.ne.jp.
[Ti] Title:Acute aggravation of subdural fluid collection associated with dural metastasis of malignant neoplasms: case report and review of the literature.
[So] Source:Brain Tumor Pathol;31(4):299-303, 2014 Oct.
[Is] ISSN:1861-387X
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:A 63-year-old woman was admitted to our hospital with serious headache and vomiting. Five months before admission, she had undergone surgery for a primary advanced gastric cancer. Neuroradiological examinations revealed subdural fluid collection. We twice performed evacuation of the subdural fluid collection. However, aggravation of her state of consciousness progressed and she passed away. Histological examinations demonstrated that the dural veins were infiltrated by numerous tumor cells that produced mucus; however, ruptured vessels were not found. Furthermore, the subdural fluid collection increased shortly after the initial operation. We infer that the cause of the collection, which was associated with the dural metastasis of malignant tumors, was not only mucin secretion by tumor cells but also a rapid increase in perfusion pressure in the vessels of the dura mater, resulting in extravasation of plasma components into the subdural space. Our case demonstrates that the pathogenetic mechanism that is specific for subdural fluid collection caused by dural metastasis of malignant tumors differs from the mechanism of production of subdural hematoma associated with dural metastasis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1410
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s10014-013-0162-0

  5 / 157035 MEDLINE  
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[PMID]: 25325211
[Au] Autor:Ebrahimifard F; Shirvani A; Abtahi S; Setayesh A
[Ad] Address:Department of General Surgery, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. dralisetayesh@yahoo.com....
[Ti] Title:Internal jugular catheter malposition in a patient with end stage renal disease: a case report.
[So] Source:Acta Med Iran;52(9):721-4, 2014 Sep.
[Is] ISSN:1735-9694
[Cp] Country of publication:Iran
[La] Language:eng
[Ab] Abstract:A 30-year-old female with end-stage renal disease was a candidate for dual lumen catheter placement. After catheter insertion, O2 saturation measurement of the aspirated blood from the catheter was similar to that of arterial blood. They referred the patient to our hospital after 48 hours. Diagnostic procedures revealed that the tip of the catheter had entered the pleural cavity. Catheter removal in the CPR room resulted in hemorrhagic shock. The patient was resuscitated and stabilized and sent to the operating room. A laceration found at the junction of right jugular and right subclavian veins and was surgically repaired. The patient was discharged after ten days without any complication.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1410
[Js] Journal subset:IM
[St] Status:In-Data-Review

  6 / 157035 MEDLINE  
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[PMID]: 24610385
[Au] Autor:Qureshi MU; Vaughan GD; Sainsbury C; Johnson M; Peskin CS; Olufsen MS; Hill NA
[Ad] Address:Department of Mathematics, International Islamic University, Sector H10, Islamabad, 44000, Pakistan, m.qureshi.2@research.gla.ac.uk.
[Ti] Title:Numerical simulation of blood flow and pressure drop in the pulmonary arterial and venous circulation.
[So] Source:Biomech Model Mechanobiol;13(5):1137-54, 2014 Oct.
[Is] ISSN:1617-7940
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:A novel multiscale mathematical and computational model of the pulmonary circulation is presented and used to analyse both arterial and venous pressure and flow. This work is a major advance over previous studies by Olufsen et al. (Ann Biomed Eng 28:1281-1299, 2012) which only considered the arterial circulation. For the first three generations of vessels within the pulmonary circulation, geometry is specified from patient-specific measurements obtained using magnetic resonance imaging (MRI). Blood flow and pressure in the larger arteries and veins are predicted using a nonlinear, cross-sectional-area-averaged system of equations for a Newtonian fluid in an elastic tube. Inflow into the main pulmonary artery is obtained from MRI measurements, while pressure entering the left atrium from the main pulmonary vein is kept constant at the normal mean value of 2 mmHg. Each terminal vessel in the network of 'large' arteries is connected to its corresponding terminal vein via a network of vessels representing the vascular bed of smaller arteries and veins. We develop and implement an algorithm to calculate the admittance of each vascular bed, using bifurcating structured trees and recursion. The structured-tree models take into account the geometry and material properties of the 'smaller' arteries and veins of radii ≥ 50 µm. We study the effects on flow and pressure associated with three classes of pulmonary hypertension expressed via stiffening of larger and smaller vessels, and vascular rarefaction. The results of simulating these pathological conditions are in agreement with clinical observations, showing that the model has potential for assisting with diagnosis and treatment for circulatory diseases within the lung.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Entry month:1409
[Js] Journal subset:IM; S
[St] Status:In-Process
[do] DOI:10.1007/s10237-014-0563-y

  7 / 157035 MEDLINE  
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[PMID]: 24215669
[Au] Autor:Gijsen FJ; Schuurbiers JC; van de Giessen AG; Schaap M; van der Steen AF; Wentzel JJ
[Ad] Address:Biomedical Engineering, Department of Cardiology, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam, The Netherlands. Electronic address: f.gijsen@erasmusmc.nl....
[Ti] Title:3D reconstruction techniques of human coronary bifurcations for shear stress computations.
[So] Source:J Biomech;47(1):39-43, 2014 Jan 3.
[Is] ISSN:1873-2380
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Heterogeneity in plaque composition in human coronary artery bifurcations is associated with blood flow induced shear stress. Shear stress is generally determined by combing 3D lumen data and computational fluid dynamics (CFD). We investigated two new procedures to generate 3D lumen reconstructions of coronary artery bifurcations for shear stress computations. METHODS: We imaged 10 patients with multislice computer tomography (MSCT) and intravascular ultrasound (IVUS). The 3D reconstruction of the main branch was based on the fusion of MSCT and IVUS. The proximal part of side branch was reconstructed using IVUS data or MSCT data, resulting in two different reconstructions of the bifurcation region. The distal part of the side branch was based on MSCT data alone. The reconstructed lumen was combined with CFD to determine the shear stress. Low and high shear stress regions were defined and shear stress patterns in the bifurcation regions were investigated. RESULTS: The 3D coronary bifurcations were successfully generated with both reconstruction procedures. The geometrical features of the bifurcation region for the two reconstruction procedures did not reveal appreciable differences. The shear stress maps showed a qualitative agreement, and the low and high shear stress regions were similar in size and average shear stress values were identical. The low and high shear stress regions showed an overlap of approximately 75%. CONCLUSION: Reconstruction of the side branch with MSCT data alone is an adequate technique to study shear stress and wall thickness in the bifurcation region. The reconstruction procedure can be applied to further investigate the effect of shear stress on atherosclerosis in coronary bifurcations.
[Mh] MeSH terms primary: Coronary Vessels/anatomy & histology
Imaging, Three-Dimensional/methods
Plaque, Atherosclerotic/physiopathology
Tomography, X-Ray Computed/methods
[Mh] MeSH terms secundary: Coronary Vessels/physiopathology
Hemodynamics
Humans
Image Processing, Computer-Assisted
Models, Anatomic
Shear Strength
Stress, Mechanical
Ultrasonography, Interventional
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1410
[Js] Journal subset:IM
[Da] Date of entry for processing:131223
[St] Status:MEDLINE

  8 / 157035 MEDLINE  
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[PMID]: 25149420
[Au] Autor:Tanoue S; Kiyosue H; Mori H; Hongo N; Okahara M; Kubo T
[Ad] Address:Department of Radiology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama, Yufu, Oita, 879-5963, Japan.
[Ti] Title:Fusion imaging using subtracted and unsubtracted rotational angiography for pretherapeutic evaluation of dural arteriovenous fistulas.
[So] Source:Jpn J Radiol;32(10):600-7, 2014 Oct.
[Is] ISSN:1867-108X
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:PURPOSE: We describe the clinical utility of an imaging technique that combines 3D subtracted and unsubtracted rotational angiography for evaluation of the angioarchitecture of dural arteriovenous fistulas (DAVFs). METHODS: From May 2010 to June 2013, 21 consecutive patients with intracranial DAVFs (22 lesions) underwent 3D angiography for pretherapeutic evaluation. 3D fusion angiography (3DFA) images were semiautomatically obtained from a dataset of unsubtracted and subtracted rotational angiographs. Multiplanar reformatted images and partial MIP images from unsubtracted rotational angiography and fusion images were evaluated by two radiologists, with particular focus on visualization of feeding arteries, shunted pouches, and drainage veins of DAVFs by use of a 3-point scale. The referring neuroradiologists were asked whether the information provided by 3DFA was helpful for treatment decisions. RESULTS: For 21 of 22 lesions, all evaluated items were well depicted on the 3DFA. The visualization rating score for feeding arteries and shunted pouches on 3DFA were significantly higher than those of 3D digital angiography (p < 0.05). There were no statistically significant differences between visualization of drainage veins. The information provided by the fusion images was helpful for treatment decisions in all cases. CONCLUSION: 3DFA images are useful for evaluation of the angioarchitecture of intracranial DAVFs.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1410
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s11604-014-0351-8

  9 / 157035 MEDLINE  
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[PMID]: 25139450
[Au] Autor:Yamada M; Nakano T; Sato C; Nakagawa A; Fujishima F; Kawagishi N; Nakanishi C; Sakurai T; Miyata G; Tominaga T; Ohuchi N
[Ad] Address:Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine, Sendai, Japan.
[Ti] Title:The dissection profile and mechanism of tissue-selective dissection of the piezo actuator-driven pulsed water jet as a surgical instrument: laboratory investigation using Swine liver.
[So] Source:Eur Surg Res;53(1-4):61-72, 2014.
[Is] ISSN:1421-9921
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:BACKGROUND/PURPOSE: The water jet technique dissects tissue while sparing cord-like structures such as blood vessels. The mechanism of such tissue-selective dissection has been unknown. The novel piezo actuator-driven pulsed water jet (ADPJ) system can achieve dissection with remarkably reduced water consumption compared to the conventional water jet; however, the system's characteristics and dissection capabilities on any organ have not been clarified. The purposes of this study were to characterize the physical properties of the novel ADPJ system, evaluate the dissection ability in swine organs, and reveal the mechanism of tissue-selective dissection. METHODS: The pulsed water jet system comprised a pump chamber driven by a piezo actuator, a stainless steel tube, and a nozzle. The peak pressure of the pulsed water jet was measured through a sensing hole using a pressure sensor. The pulsed water jet technique was applied on swine liver in order to dissect tissue on a moving table using one-way linear ejection at a constant speed. The dissection depth was measured with light microscopy and evaluated histologically. The physical properties of swine liver were evaluated by breaking strength tests using tabletop universal testing instruments. The liver parenchyma was also cut with three currently available surgical devices to compare the histological findings. RESULTS: The peak pressure of the pulsed water jet positively correlated with the input voltage (R(2) = 0.9982, p < 0.0001), and this was reflected in the dissection depth. The dissection depth negatively correlated with the breaking strength of the liver parenchyma (R(2) = 0.6694, p < 0.0001). The average breaking strengths of the liver parenchyma, hepatic veins, and Glisson's sheaths were 1.41 ± 0.45, 8.66 ± 1.70, and 29.6 ± 11.0 MPa, respectively. The breaking strength of the liver parenchyma was significantly lower than that of the hepatic veins and Glisson's sheaths. Histological staining confirmed that the liver parenchyma was selectively dissected, preserving the hepatic veins and Glisson's sheaths in contrast to what is commonly observed with electrocautery or ultrasonic instruments. CONCLUSIONS: The dissection depth of liver tissue is well controlled by input voltage and is influenced by the moving velocity and the physical properties of the organ. We showed that the device can be used to assure liver resection with tissue selectivity due to tissue-specific physical properties. Although this study uses an excised organ, further in vivo studies are necessary. The present work demonstrates that this device may function as an alternative tool for surgery due to its good controllability of the dissection depth and ability of tissue selectivity. © 2014 S. Karger AG, Basel.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1410
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1159/000365288

  10 / 157035 MEDLINE  
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[PMID]: 25227957
[Au] Autor:Chen P; Wang W; Yan L; Wen T; Li B; Zhao J
[Ad] Address:Department of Liver and Vascular Surgery, West China Hospital of Sichuan University, Chengdu, PR China.
[Ti] Title:Reconstructing middle hepatic vein tributaries in right-lobe living donor liver transplantation.
[So] Source:Dig Surg;31(3):210-8, 2014.
[Is] ISSN:1421-9883
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:AIMS: To investigate the effectiveness of our technique and policy in reconstructing middle hepatic vein (MHV) tributaries of patients undergoing right-lobe living donor liver transplantation (LDLT). METHODS: From January 2001 to December 2010, 186 adult patients underwent right-lobe LDLT without the MHV. Patients were divided into two groups: group A (n = 71) and group B (n = 115) without or with the MHV tributaries reconstruction. We evaluated the serum liver function markers after transplantation and monitored vascular flow in the graft and interpositional vein by Doppler ultrasonography. RESULTS: The cumulative 1-, 3-, 5-year graft and patient survival rates were not significant between group A and group B (p = 0.287 and p = 0.258). Biliary complications appeared to be more frequent in group A than in group B (16.9 vs. 5.2%, p = 0.009). Liver function impairment was found in patients without MHV reconstruction and those with occluded interpositional vessels early after transplantation. The cumulative 1-, 3-, 6- and 12-month patency rate of the interpositional veins was 81.51, 79.60, 74.69 and 72.68%, respectively. CONCLUSION: The reconstruction technique based on our policy ensures excellent outflow drainage and favorable recipient outcome, while better criteria for MHV reconstruction should be established. © 2014 S. Karger AG, Basel.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1410
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1159/000363416


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