Database : MEDLINE
Search on : Vitamin and E and Deficiency [Words]
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[PMID]: 29514147
[Au] Autor:Stone CA; McEvoy CT; Aschner JL; Kirk A; Rosas-Salazar C; Cook-Mills JM; Moore PE; Walsh WF; Hartert TV
[Ad] Address:Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
[Ti] Title:Update on Vitamin E and Its Potential Role in Preventing or Treating Bronchopulmonary Dysplasia.
[So] Source:Neonatology;113(4):366-378, 2018 Mar 07.
[Is] ISSN:1661-7819
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Vitamin E is obtained only through the diet and has a number of important biological activities, including functioning as an antioxidant. Evidence that free radicals may contribute to pathological processes such as bronchopulmonary dysplasia (BPD), a disease of prematurity associated with increased lung injury, inflammation and oxidative stress, led to trials of the antioxidant vitamin E (α-tocopherol) to prevent BPD with variable results. These trials were all conducted at supraphysiologic doses and 2 of these trials utilized a formulation containing a potentially harmful excipient. Since 1991, when the last of these trials was conducted, both neonatal management strategies for minimizing oxygen and ventilator-related lung injury and our understanding of vitamin E isoforms in respiratory health have advanced substantially. It is now known that there are differences between the effects of vitamin E isoforms α-tocopherol and γ-tocopherol on the development of respiratory morbidity and inflammation. What is not known is whether improvements in physiologic concentrations of individual or combinations of vitamin E isoforms during pregnancy or following preterm birth might prevent or reduce BPD development. The answers to these questions require adequately powered studies targeting pregnant women at risk of preterm birth or their premature infants immediately following birth, especially in certain subgroups that are at increased risk of vitamin E deficiency (e.g., smokers). The objective of this review is to compile, update, and interpret what is known about vitamin E isoforms and BPD since these first studies were conducted, and suggest future research directions.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:Publisher
[do] DOI:10.1159/000487388

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[PMID]: 29505508
[Au] Autor:Li W; Cheng X; Guo L; Li H; Sun C; Cui X; Zhang Q; Song G
[Ad] Address:Department of ICU, Affiliated Children's Hospital of Capital Institute of Pediatrics.
[Ti] Title:Association between serum 25-hydroxyvitamin D concentration and pulmonary infection in children.
[So] Source:Medicine (Baltimore);97(1):e9060, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:We assessed the relationship between serum 25-hydroxyvitamin D (25(OH)D) level and community-acquired pneumonia (CAP) among Chinese children.This observational study examined children aged 3 days to 14 years (n = 1582) from the Capital Institute of Pediatrics in 2009 to 2011. There were 797 children in the CAP group and 785 controls. The CAP group was divided into 2 groups: a pneumonia group and pneumonia-induced sepsis group. The serum 25(OH)D level was estimated using micro whole blood chemiluminescence.The average serum 25(OH)D level in all samples was 25.32  14.07 ng/mL, with the CAP group showing a lower value than the control group (P < .001). There were also significant differences between the pneumonia group and pneumonia-induced sepsis group (P < .001). In the pneumonia-induced sepsis group, significant differences in serum 25(OH)D levels were observed in children who received mechanical ventilation or presenting with multiple organ dysfunction (P < .01).All serum 25(OH)D levels in the pneumonia group and pneumonia-induced sepsis group were below normal levels, particularly in the sepsis group. A lower serum 25(OH)D level was associated with more serious symptoms in CAP children. Children with low serum 25(OH)D levels may be at higher risk of receiving mechanical ventilation and presenting with multiple organ dysfunction. These findings suggest that vitamin D supplements are beneficial for the treatment and prevention of CAP.
[Mh] MeSH terms primary: Pneumonia/blood
Vitamin D Deficiency/complications
Vitamin D/analogs & derivatives
[Mh] MeSH terms secundary: Adolescent
Case-Control Studies
Child
Child, Preschool
Community-Acquired Infections/blood
Community-Acquired Infections/etiology
Female
Humans
Infant
Infant, Newborn
Male
Nutritional Status
Pneumonia/etiology
ROC Curve
Seasons
Sepsis/blood
Sepsis/etiology
Vitamin D/blood
[Pt] Publication type:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Name of substance:1406-16-2 (Vitamin D); 64719-49-9 (25-hydroxyvitamin D)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180306
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009060

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[PMID]: 29378042
[Au] Autor:Aibana O; Franke MF; Huang CC; Galea JT; Calderon R; Zhang Z; Becerra MC; Smith ER; Contreras C; Yataco R; Lecca L; Murray MB
[Ad] Address:Division of General Internal Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX.
[Ti] Title:Vitamin E Status Is Inversely Associated with Risk of Incident Tuberculosis Disease among Household Contacts.
[So] Source:J Nutr;148(1):56-62, 2018 Jan 01.
[Is] ISSN:1541-6100
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Background: Few studies have previously assessed how pre-existing vitamin E status is associated with risk of tuberculosis (TB) disease progression. Objective: We evaluated the association between baseline plasma concentrations of 3 vitamin E isomers (α-tocopherol, γ-tocopherol, and δ-tocopherol) and TB disease risk. Methods: We conducted a case-control study nested within a longitudinal cohort of household contacts (HHCs) of pulmonary TB cases in Lima, Peru. We defined cases as HHCs who developed active TB disease ≥15 d after the diagnosis of the index patient, and we matched each case to 4 control cases who did not develop active TB based on age by year and gender. We used univariate and multivariate conditional logistic regression to calculate ORs for incident TB disease by plasma concentrations of α-tocopherol, γ-tocopherol, and δ-tocopherol. Results: Among 6751 HIV-negative HHCs who provided baseline blood samples, 180 developed secondary TB during follow-up. After controlling for possible confounders, we found that baseline α-tocopherol deficiency conferred increased risk of incident TB disease (adjusted OR: 1.59; 95% CI: 1.02, 2.50; P = 0.04). Household contacts in the lowest tertile of δ-tocopherol were also at increased risk of progression to TB disease compared to those in the highest tertile (tertile 1 compared with tertile 3, adjusted OR: 2.29; 95% CI: 1.29, 4.09; P-trend = 0.005). We found no association between baseline concentration of γ-tocopherol and incident TB disease. Conclusions: Vitamin E deficiency was associated with an increased risk of progression to TB disease among HHCs of index TB cases. Assessment of vitamin E status among individuals at high risk for TB disease may play a role in TB control efforts.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Data-Review
[do] DOI:10.1093/jn/nxx006

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[PMID]: 29490621
[Au] Autor:Fcker M; Antel J; Grasemann C; Fhrer D; Timmesfeld N; ztrk D; Peters T; Hinney A; Hebebrand J; Libuda L
[Ad] Address:Department of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, Wickenburgstr. 21, D-45147, Essen, Germany. manuel.foecker@uni-due.de.
[Ti] Title:Effect of an vitamin D deficiency on depressive symptoms in child and adolescent psychiatric patients - a randomized controlled trial: study protocol.
[So] Source:BMC Psychiatry;18(1):57, 2018 Mar 01.
[Is] ISSN:1471-244X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Depression is a significant health and economic burden worldwide affecting not only adults but also children and adolescents. Current treatment options for this group are scarce and show moderate effect sizes. There is emerging evidence that dietary patterns and specific nutritional components might play a role in the risk for developing depression. This study protocol focusses on the role of vitamin D which is for long known to be relevant for calcium and phosphorous homeostasis and bone health but might also impact on mental health. However, the assessment of the vitamin D status of depressed juvenile patients, or supplementation of vitamin D is currently not part of routine treatment. Controlled intervention studies are indispensable to prove whether a vitamin D deficiency ameliorates depressive symptoms. METHODS/DESIGN: This double blinded, randomized controlled trial will enroll 200 inpatients from a child and adolescent psychiatric department with a vitamin D deficiency defined by a 25(OH)-vitamin D-level < 30nmol/l (12ng/ml) and a Beck Depressions Inventory (BDI-II) score > 13 (indicating at least: mild depression). Upon referral, all patients will be screened, checked for inclusion criteria, and those eligible will be randomized after written consent into a supplementation or placebo group. Both study-arms will receive treatment-as-usual for their psychiatric disorder according to established clinical guidelines. The participants of the vitamin D supplementation group will receive 2640I.E. vitamin D3 q.d. for 28days in accordance with best practice in pediatric endocrinology. We hypothesize that delaying supplementation of vitamin D in the placebo arm will affect the treatment success of the depressive symptomatology in comparison to the vitamin D supplementation group. Patients will be enrolled for a period of 28days based on the mean length of hospitalization of juveniles with depression. DISCUSSION: Randomized controlled trials in children and adolescents with depression are needed to elucidate the role of a vitamin D deficiency for mental disorders and to investigate the relevance of a routine assessment and supplementation of vitamin D deficits. TRIAL REGISTRATION: DRKS00009758, 16/06/2016 (retrospectively registered).
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Data-Review
[do] DOI:10.1186/s12888-018-1637-7

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[PMID]: 28464292
[Au] Autor:Charbgoo F; Behmanesh M; Nikkhah M; Kane EG
[Ad] Address:Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
[Ti] Title:RNAi mediated gene silencing of ITPA using a targeted nanocarrier: Apoptosis induction in SKBR3 cancer cells.
[So] Source:Clin Exp Pharmacol Physiol;44(8):888-894, 2017 Aug.
[Is] ISSN:1440-1681
[Cp] Country of publication:Australia
[La] Language:eng
[Ab] Abstract:A pure nucleotide pool is required for high-fidelity DNA replication and prevention of carcinogenesis in living cells. Human inosine triphosphatase (ITPase), encoded by the ITPA gene, plays a critical role in maintaining the purity of the cellular nucleotide pool by excluding nucleotides that enhance mutagenesis. ITPase is a nucleoside triphosphate pyrophosphatase that hydrolyzes the non-canonical nucleotides inosine triphosphate (ITP) and xanthine triphosphate (XTP). The monophosphate products of ITPase reactions are subsequently excluded from the nucleotide pool and the improper substitution of ITP and XTP into DNA and RNA is prevented. Previous studies show that deficiency in ITPA can suppress cellular growth and enhance DNA instability. In this study, we evaluated the influence of effective ITPA down-regulation on the induction of apoptosis in a human cancer cell line using folate-single wall nanotubes (SWNT) as a targeted nanocarrier. We assessed whether SWNT enhances IPTA-siRNA transfection efficiency in cancer cells using folate as a homing device. Since folate receptor is considerably overexpressed in cancer cells, conjugation of SWNTs to folate could enhance their cancer-specific penetrance. We found that nanocarrier mediated ITPA-siRNA transfection into SKBR3 cells caused significant reduction of ITPA mRNA expression level and complete down-regulation of the ITPase protein product. The silencing of ITPA led to promotion of apoptosis in SWNT-treated SKBR3 cancer cells.
[Mh] MeSH terms primary: Apoptosis/genetics
Drug Carriers/chemistry
Nanostructures/chemistry
Nanotubes, Carbon/chemistry
Pyrophosphatases/deficiency
Pyrophosphatases/genetics
RNA Interference
[Mh] MeSH terms secundary: Cell Line, Tumor
Down-Regulation/genetics
Folic Acid/chemistry
Humans
Hydrolysis
RNA, Small Interfering/chemistry
RNA, Small Interfering/genetics
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Drug Carriers); 0 (Nanotubes, Carbon); 0 (RNA, Small Interfering); 935E97BOY8 (Folic Acid); EC 3.6.1.- (Pyrophosphatases); EC 3.6.1.19 (ITPA protein, human)
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[Js] Journal subset:IM
[Da] Date of entry for processing:170503
[St] Status:MEDLINE
[do] DOI:10.1111/1440-1681.12776

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[PMID]: 29509296
[Au] Autor:Jeremic J; Nikolic Turnic T; Zivkovic V; Jeremic N; Milosavljevic I; Srejovic I; Obrenovic R; Jancic S; Rakocevic M; Matic S; Djuric D; Jakovljevic V
[Ad] Address:University of Kragujevac, Department of Pharmacy, Faculty of Medical Sciences, Kragujevac, Serbia.
[Ti] Title:Vitamin b complex mitigates cardiac dysfunction in high-methionine diet-induced hyperhomocysteinemia.
[So] Source:Clin Exp Pharmacol Physiol;, 2018 Mar 06.
[Is] ISSN:1440-1681
[Cp] Country of publication:Australia
[La] Language:eng
[Ab] Abstract:This research is designed to test the hypothesis that elevated homocysteine (Hcy) levels in vivo, caused by a deficit in vitamin B complex, promote changes in cardiac function and redox status that lead to heart failure. In order to conduct the study, we used adult male Wistar albino rats (n=30; 4 weeks old; 10015 g body weight). Hyperhomocysteinemia (HHcy) in these animals was achieved by dietary manipulation. For 4 weeks, the animals were fed with a standard rodent chow (control - CF), a diet enriched in methionine with no deficiency in B vitamins (i.e., folic acid, B6 and B12) (HMNV) or a diet enriched in methionine and deficient in B vitamins (HMLV). After 28 days of dietary manipulation, all animals were sacrificed. The rat hearts were isolated and retrogradely perfused according to the Langendorff technique at a gradually increasing perfusion pressure. We found a negative correlation between elevated serum Hcy and total body and heart weight. The maximum rate of left ventricular pressure development was significantly increased in the HMNV group compared with in the other groups. Systolic left ventricular pressure was significantly changed in all groups. HHcy induces remodelling of the cardiac tissues, as moderate HHcy is associated with more prominent interstitial and perivascular fibrosis. Our results suggest that a high methionine diet without vitamin B complex causes profound negative effects associated with HHcy. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:Publisher
[do] DOI:10.1111/1440-1681.12930

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[PMID]: 27771345
[Au] Autor:Zheng SZ; Zhang DG; Wu H; Jiang LJ; Jin J; Lin XQ; Ding R; Jiang Y
[Ad] Address:Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
[Ti] Title:The association between vitamin D receptor polymorphisms and serum 25-hydroxyvitamin D levels with ulcerative colitis in Chinese Han population.
[So] Source:Clin Res Hepatol Gastroenterol;41(1):110-117, 2017 Feb.
[Is] ISSN:2210-741X
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:There is now growing evidence suggesting that Vitamin D is playing a critical role in modulating the innate and adaptive immune responses. Several polymorphisms have been identified in the vitamin D receptor (VDR) gene but their association with ulcerative colitis (UC) susceptibility remained controversy. In the current study, we examined the association between VDR polymorphisms and serum level of 25-hydroxyvitamin D [25(OH)D] with UC in Chinese Han population. Polymorphisms of FokI (rs2228570)/BsmI (rs1544410)/ApaI (rs7975232)/TaqI (rs731236) in the VDR gene were assessed in a case-control study comprising 404 UC patients and 612 controls. Moreover, 25(OH)D levels were measured by electro-chemiluminescence immunoassay in 75 UC patients and 120 controls. Our results suggested that BsmI polymorphism frequency was significantly lower in UC patients (P=0.028), and the frequency of AAC haplotype formed by BsmI, ApaI and TaqI was also significantly lower in UC patients (P=0.012). Moreover, FokI polymorphism was more frequently observed in patients with mild and moderate UC as compared to those with severe UC (P=0.001, P<0.001, respectively). Average 25(OH)D level was lower in UC patients than in controls (19.36.8 vs. 21.87.3ng/mL, P=0.017), and was significantly correlated with hemoglobin (=0.49, P<0.001), C-reactive protein (=-0.36, P<0.001), severity of UC (=-0.21, P=0.025) and FokI polymorphism (=-0.20, P=0.031) in UC patients. Interestingly, there was a significant correlation between FokI polymorphism and vitamin D deficiency (<20ng/mL) in UC patients (P=0.006). Together, these results supported that VDR polymorphisms and 25(OH)D level were significantly correlated with UC risk and severity in Chinese Han population.
[Mh] MeSH terms primary: Colitis, Ulcerative/genetics
Polymorphism, Single Nucleotide/genetics
Receptors, Calcitriol/genetics
Vitamin D/analogs & derivatives
[Mh] MeSH terms secundary: Adult
Alleles
Asian Continental Ancestry Group/statistics & numerical data
Case-Control Studies
China/epidemiology
Colitis, Ulcerative/ethnology
Female
Genotype
Humans
Male
Middle Aged
Vitamin D/blood
Vitamin D/genetics
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Receptors, Calcitriol); 1406-16-2 (Vitamin D); 64719-49-9 (25-hydroxyvitamin D)
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:IM
[Da] Date of entry for processing:161025
[St] Status:MEDLINE

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[PMID]: 29497932
[Au] Autor:El-Ansary A; Cannell JJ; Bjrklund G; Bhat RS; Al Dbass AM; Alfawaz HA; Chirumbolo S; Al-Ayadhi L
[Ad] Address:Central Laboratory, Female Centre for Scientific and Medical Studies, King Saud University, Riyadh, Saudi Arabia.
[Ti] Title:In the search for reliable biomarkers for the early diagnosis of autism spectrum disorder: the role of vitamin D.
[So] Source:Metab Brain Dis;, 2018 Mar 01.
[Is] ISSN:1573-7365
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Autism spectrum disorder (ASD) affects about 1% of the world's population. Vitamin D is thought to be essential for normal brain development and modulation of the immune system. Worldwide about 1 billion people are affected by vitamin D deficiency. High-sensitivity C-reactive protein (hs-CRP), cytochrome P450 2E1 (CYP2E1) and 8-hydroxy-2'-deoxyguanosine (8-OH-dG) are biomarkers related to inflammation and oxidative stress. In the present study, these biomarkers were together with serum 25-hydroxyvitamin D (25(OH)D ) analyzed in 28 (mean age seven years) Saudi male patients with ASD. The study was conducted to determine if there is any relationship between vitamin D levels, the tested biomarkers and the presence and severity of ASD. The hope was to identify if these biomarkers may be useful for early ASD diagnosis. The Childhood Autism Rating Scale (CARS) and the Social Responsiveness Scale (SRS) were used to measure autism severity. The results of the ASD children were compared with 27 age and gender-matched neurotypical controls. The data indicated that Saudi patients with ASD have significantly lower plasma levels of 25(OH)D than neurotypical controls (38ng/ml compared to 56ng/ml, respectively; [P = 0.001]). Surprisingly, the levels of CYP2E1 were lower in the children with ASD than the neurotypical controls (0.48 0.08 vs. 69 0.07ng/ml, respectively; P = 0.001). The ASD children also had significantly higher levels of hs-CRP (0.79 0.09 vs. 0.590.09ng/ml, respectively; P = 0.001) and 8-OH-dG (8.17 1.04 vs. 4.13 1.01ng/ml, respectively; P = 0.001, compared to neurotypical age and gender-matched controls. The values for hs-CRP and 8-OH-dG did not correlate [P < 0.001] with autism severity. There was found a relationship between autism severity on the CARS scale and the levels of 25(OH)D and CYP1B1. But this was not found for SRS. All four biomarkers seemed to have good sensitivity and specificity, but the sample size of the present study was too small to determine clinical usefulness. The findings also indicate that inadequate levels of vitamin D play a role in the etiology and severity of autism. Furthermore, the results of the present study suggest the possibility of using 25(OH)D , CYP1B1, hs-CRP and 8-OH-dG, preferably in combination, as biomarkers for the early diagnosis of ASD. However, further research is needed to evaluate this hypothesis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:Publisher
[do] DOI:10.1007/s11011-018-0199-1

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[PMID]: 29390321
[Au] Autor:Bichon A; Aubry C; Benarous L; Drouet H; Zandotti C; Parola P; Lagier JC
[Ad] Address:Aix Marseille Univ, CNRS 7278, IRD 198, INSERM 1095, AP-HM, URMITE, IHU Mditerrane-Infection, 19-21 Boulevard Jean Moulin, Marseille Cedex 5.
[Ti] Title:Case report: Ribavirin and vitamin A in a severe case of measles.
[So] Source:Medicine (Baltimore);96(50):e9154, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Despite a vaccine being widely available, measles continues to occur frequently, with sometimes lethal consequences. PATIENTS CONCERNS: The mortality rate reaches 35% and measles represents 44% of the 1.4 million deaths which are due to preventable diseases. Severe forms of measles are reported, mainly in young, unvaccinated adults, and in specific populations. The risk factors for severe measles include no or incomplete vaccination and vitamin A deficiency. Apart from secondary measles-related infections, severe measles is mainly represented by neurological, respiratory, and digestive symptoms. DIAGNOSES: Strengthening the hypothesis that there is a link between vitamin A deficiency and severe measles in this paper we report the case of a 25-year-old unvaccinated man hospitalized for severe and complicated measles. OUTCOMES: The evolution was good after administration of intramuscular vitamin A as well as intravenous ribavirin. LESSONS: Measles remains a fatal and serious disease. The early use of ribavirin and vitamin A shows significant improvements regarding morbimortality and should be systematic in severe cases.
[Mh] MeSH terms primary: Antiviral Agents/therapeutic use
Measles/prevention & control
Ribavirin/therapeutic use
Vitamin A/therapeutic use
[Mh] MeSH terms secundary: Adult
Humans
Male
Measles/complications
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Antiviral Agents); 11103-57-4 (Vitamin A); 49717AWG6K (Ribavirin)
[Em] Entry month:1802
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009154

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[PMID]: 28463086
[Au] Autor:Mann EH; Ho TR; Pfeffer PE; Matthews NC; Chevretton E; Mudway I; Kelly FJ; Hawrylowicz CM
[Ad] Address:1 MRC and Asthma-UK Centre for Allergic Mechanisms in Asthma, and.
[Ti] Title:Vitamin D Counteracts an IL-23-Dependent IL-17A IFN-γ Response Driven by Urban Particulate Matter.
[So] Source:Am J Respir Cell Mol Biol;57(3):355-366, 2017 09.
[Is] ISSN:1535-4989
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Urban particulate matter (UPM) air pollution and vitamin D deficiency are detrimentally associated with respiratory health. This is hypothesized to be due in part to regulation of IL-17A, which UPM is reported to promote. Here, we used a myeloid dendritic cell (DC)-memory CD4 T cell co-culture system to characterize UPM-driven IL-17A cells, investigate the mechanism by which UPM-primed DCs promote this phenotype, and address evidence for cross-regulation by vitamin D. CD1c myeloid DCs were cultured overnight with or without a reference source of UPM and/or active vitamin D (1,25[OH] D ) before they were co-cultured with autologous memory CD4 T cells. Supernatants were harvested for cytokine analysis on Day 5 of co-culture, and intracellular cytokine staining was performed on Day 7. UPM-primed DCs increased the proportion of memory CD4 T cells expressing the T helper 17 cell (Th17)-associated cytokines IL-17A, IL-17F, and IL-22, as well as IFN-γ, granulocyte-macrophage colony-stimulating factor, and granzyme B. Notably, a large proportion of the UPM-driven IL-17A cells co-expressed these cytokines, but not IL-10, indicative of a proinflammatory Th17 profile. UPM-treated DCs expressed elevated levels of il23 mRNA and increased secretion of IL-23p40. Neutralization of IL-23 in culture reduced the frequency of IL-17A IFN-γ cells without affecting cell proliferation. 1,25(OH) D counteracted the UPM-driven DC maturation and inhibited the frequency of IL-17A IFN-γ cells, most prominently when DCs were co-treated with the corticosteroid dexamethasone, while maintaining antiinflammatory IL-10 synthesis. These data indicate that UPM might promote an inflammatory milieu in part by inducing an IL-23-driven proinflammatory Th17 response. Restoring vitamin D sufficiency may counteract these UPM-driven effects without obliterating important homeostatic immune functions.
[Mh] MeSH terms primary: Cities
Interferon-gamma/metabolism
Interleukin-17/metabolism
Interleukin-23/metabolism
Particulate Matter/toxicity
Vitamin D/pharmacology
[Mh] MeSH terms secundary: Calcitriol/pharmacology
Cell Differentiation/drug effects
Dendritic Cells/drug effects
Dendritic Cells/metabolism
Dexamethasone/pharmacology
Humans
Myeloid Cells/drug effects
Myeloid Cells/metabolism
Phenotype
Th17 Cells/immunology
Up-Regulation/drug effects
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (IL17A protein, human); 0 (Interleukin-17); 0 (Interleukin-23); 0 (Particulate Matter); 1406-16-2 (Vitamin D); 7S5I7G3JQL (Dexamethasone); 82115-62-6 (Interferon-gamma); FXC9231JVH (Calcitriol)
[Em] Entry month:1709
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[Js] Journal subset:IM
[Da] Date of entry for processing:170503
[St] Status:MEDLINE
[do] DOI:10.1165/rcmb.2016-0409OC


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