Database : MEDLINE
Search on : Vitiligo [Words]
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[PMID]: 29524288
[Au] Autor:Ibrahim H; El Taieb M; El Gamel Z; El Saied AR
[Ad] Address:Department of Dermatology, Venereology and Andrology, Qena Faculty of Medicine, South Valley University, Qena, Egypt.
[Ti] Title:Effect of narrow-band ultraviolet B on the serum of 25-hydroxyvitamin D in vitiligo patients.
[So] Source:J Cosmet Dermatol;, 2018 Mar 10.
[Is] ISSN:1473-2165
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Narrow-band ultraviolet B (NB-UVB) is the gold standard in the treatment of vitiligo. 25-hydroxyvitamin D (25-OH- vitamin D) might play a physiological role in photo-induced melanogenesis in human skin so the association between vitamin D levels and vitiligo still needs to be investigated more thoroughly. OBJECTIVE: we aim to investigate the influence of cumulative doses of NB-UVB phototherapy on vitamin D in patients with vitiligo and their correlation with NB-UVB-induced pigmentation. METHODS: Eighty patients of vitiligo and twenty number of age and sex matched controls were recruited in a case-control study. Patients with vitiligo were treated with NB-UVB twice weekly for 24 weeks. 25-hydroxy vitamin D levels were measured at 0, 12, and 24 weeks in the cases and at 0 only in control by enzyme-linked immunosorbent assay (ELISA) and Vitiligo Area Severity Index (VASI) were calculated at 0 (baseline) and 24 weeks. RESULTS: The mean baseline level of 25-hydroxyvitamin D (at 0 week) was significantly lower in patients than the control group. Levels of 25(OH) vitamin D at 12 and 24 weeks showed significant improvement and Patients show significant reduction in VASI score after 24 weeks of therapy. CONCLUSIONS: Cumulative doses of NB-UVB therapy improve low vitamin D levels in patients with vitiligo, which might have a significant role in NB-UVB-induced repigmentation and may contribute to its therapeutic efficacy but further studies with larger sample size are needed to prove the complete mechanisms of NB-UVB-induced pigmentations and vitamin D in vitiligo.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher
[do] DOI:10.1111/jocd.12515

  2 / 6270 MEDLINE  
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[PMID]: 29520803
[Au] Autor:Correia LD; Silva de Castro CC
[Ad] Address:School of Medicine, Pontifícia Universidade Católica do Paraná - PUCPR, Curitiba, Brazil.
[Ti] Title:Association between bilateral segmental vitiligo and lichen striatus: an expression of mosaicism?
[So] Source:Int J Dermatol;, 2018 Mar 08.
[Is] ISSN:1365-4632
[Cp] Country of publication:England
[La] Language:eng
[Pt] Publication type:CASE REPORTS
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1111/ijd.13964

  3 / 6270 MEDLINE  
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[PMID]: 29451155
[Au] Autor:Li YL; Wang H; Qi RQ; Hong YX; Zheng S; Xiao BH; An Q; Li JH; Chen HD; Gao XH
[Ad] Address:Department of Dermatology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China.
[Ti] Title:Proteomic Analysis of the Serum of Patients with Stable Vitiligo and Progressive Vitiligo.
[So] Source:Chin Med J (Engl);131(4):480-483, 2018 Feb 20.
[Is] ISSN:0366-6999
[Cp] Country of publication:China
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1802
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review
[do] DOI:10.4103/0366-6999.225055

  4 / 6270 MEDLINE  
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[PMID]: 29444382
[Au] Autor:Sharma S; Parsad D; Bhattacharjee R; Muthu SK
[Ad] Address:Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
[Ti] Title:A prospective right-left comparative study to evaluate the efficacy and tolerability of combination of NB-UVB and topical bimatoprost 0.03% eye drops versus NB-UVB given alone in patients of vitiligo vulgaris.
[So] Source:J Eur Acad Dermatol Venereol;, 2018 Feb 14.
[Is] ISSN:1468-3083
[Cp] Country of publication:England
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1802
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1111/jdv.14882

  5 / 6270 MEDLINE  
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[PMID]: 29180313
[Au] Autor:Wang T; Ren Y; Di D; Zhu Q; Luo G
[Ad] Address:Dermatology Hospital of Southern Medical University, Dermatology Hospital of Guangdong province, 2 Lujing Road, Yuexiu district, 510095 Guangzhou, China.
[Ti] Title:Segmental vitiligo treated by fire needle therapy: a case series.
[So] Source:Eur J Dermatol;28(1):118-119, 2018 Feb 01.
[Is] ISSN:1952-4013
[Cp] Country of publication:France
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review
[do] DOI:10.1684/ejd.2017.3185

  6 / 6270 MEDLINE  
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[PMID]: 29454011
[Au] Autor:Zheleva A; Nikolova G; Karamalakova Y; Hristakieva E; Lavcheva R; Gadjeva V
[Ad] Address:Department of Chemistry and Biochemistry, Medical Faculty, Trakia University, Stara Zagora, Bulgaria. Electronic address: azheleva@mf.uni-sz.bg.
[Ti] Title:Comparative study on some oxidative stress parameters in blood of vitiligo patients before and after combined therapy.
[So] Source:Regul Toxicol Pharmacol;94:234-239, 2018 Feb 14.
[Is] ISSN:1096-0295
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Currently accepted that oxidative stress is a triggering event in the melanocytic destruction and is probably involved in the etiopathogenesis of vitiligo disease. Despite numerous investigations, contradictory results were reported about the levels of oxidative stress biomarkers measured in the skin and blood of vitiligo patients. By Electron Paramagnetic Resonance spectroscopy (EPR) and spectrophotometry, we have investigated and compared some oxidative stress biomarkers in the blood of vitiligo patients' before and after UVB Narrow Band 311 nm phototherapy combined with the antioxidant nutritional supplement containing - Vitamin C, Vitamin B1, L -Cysteine, Lipoic Acid, and polyunsaturated fatty acids. Before therapy was found significantly higher levels of CAT activity and MDA compared to the patients after therapy and control group (p < 0.05). Moreover, levels of Asc* radicals in patients before therapy were significantly lower than those measured in controls and patients undergoing therapy (p < 0.05). Our finding, the combined therapy applied to vitiligo patients provoked an increase in the Asc* levels and a decrease in MDA products and also initial repigmentation in the vitiligo spots, made us believe that a combined antioxidant therapy, enriched with vitamin C could lead to improvement of the oxidant-antioxidant balance in vitiligo patients treated with UVB 311 phototherapy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:Publisher

  7 / 6270 MEDLINE  
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[PMID]: 29512905
[Au] Autor:Lu W; Zhao Y; Kong Y; Zhang W; Ma W; Li W; Wang K
[Ad] Address:Department of Dermatology, Qilu Hospital of Shandong University (Qingdao), Qingdao, China.
[Ti] Title:Geniposide prevents H O -induced oxidative damage in melanocytes by activating the PI3K-Akt signalling pathway.
[So] Source:Clin Exp Dermatol;, 2018 Mar 07.
[Is] ISSN:1365-2230
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Oxidative stress is one possible pathogenic event in vitiligo that induces melanocyte destruction. Geniposide exerts certain antioxidant effects on various cells by activating the phosphoinositol 3-kinase (PI3K)-Akt signalling pathway. However, researchers have not clearly determined whether geniposide protects human melanocytes from oxidative stress or identified the underlying mechanism of such protection. AIM: To determine whether geniposide protects melanocytes from H O -induced oxidative damage and to explore the role of the PI3K-Akt signalling pathway in this protective effect. METHODS: The antioxidant effects of geniposide on human melanocytes were examined by measuring cell viability, apoptosis rates, reactive oxygen species (ROS) production and activities of the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT). We examined expression of Akt, phosphorylated Akt (p-Akt), Bcl-2, Bax, and cleaved caspase 3 and cleaved caspase 9 proteins to determine the involvement of the PI3K-Akt pathway. RESULTS: Pretreatment with geniposide 5, 25, 125 or 625 µmol/L increased cell viability and decreased the apoptosis rate of H O -treated melanocytes. In addition, geniposide enhanced the antioxidant activity of SOD and CAT, and decreased intracellular ROS accumulation. Furthermore, geniposide increased the levels of p-Akt and regulated the expression of downstream proteins in the PI3K-Akt pathway, such as Bcl-2, Bax, and cleaved caspase 3 and 9, in H O -treated melanocytes. Notably, these effects were largely blocked by treatment with LY294002 prior to H O treatment. CONCLUSIONS: Based on these results, geniposide protects human melanocytes from H O -induced oxidative damage, and the PI3K-Akt signalling pathway is involved in its antioxidant effect.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:Publisher
[do] DOI:10.1111/ced.13409

  8 / 6270 MEDLINE  
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[PMID]: 29512683
[Au] Autor:Yin L; Pang G; Niu C; Habasi M; Dou J; Aisa HA
[Ad] Address:The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, Xinjiang 830011, P.R. China.
[Ti] Title:A novel psoralen derivative-MPFC enhances melanogenesis via activation of p38 MAPK and PKA signaling pathways in B16 cells.
[So] Source:Int J Mol Med;, 2018 Mar 02.
[Is] ISSN:1791-244X
[Cp] Country of publication:Greece
[La] Language:eng
[Ab] Abstract:As an active compound, psoralen is present in various Chinese herbal medicines and has exhibited significant activity in skin disease treatment. Its derivative 8-methoxypsoralan (8-MOP) is the most commonly used drug to induce repigmentation of vitiligo. In our previous screening assays, 4-methyl-6-phenyl-2H-furo[3,2-g]chromen-2-one (MPFC), a psoralen derivative, was identified as more effective tyrosinase and melanin activator than the positive control 8-MOP in consideration of low doses, as well as low toxicity. The overall purpose of this study was to characterize the melanogenic effect and mechanisms of MPFC in B16 cells. The melanin biosynthesis effects of MPFC were determined by examination of cellular melanin contents, tyrosinase activity assay, cyclic adenosinemonophosphate (cAMP) assay, and western blotting of MPFC-stimulated B16 mouse melanoma cells. Our results showed that MPFC enhanced both melanin synthesis and tyrosinase activity in a concentration-dependent manner as well as significantly activated the expression of melanogenic proteins such as tyrosinase, tyrosinase-related protein-1 and tyrosinase-related protein-2. Western blot analysis showed that MPFC increased the phosphorylation of p38 mitogen-activated protein kinase and cAMP response element-binding protein (CREB) as well as the expression of microphthalmia-associated transcription factor (MITF). Moreover, MPFC stimulated intracellular cAMP levels and induced tyrosinase activity and melanin synthesis were attenuated by H89, a protein kinase A inhibitor. These results indicated that MPFC-mediated activation of the p38 MAPK and the protein kinase A (PKA) pathway may shed light on a novel approach for an effective therapy for vitiligo.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:Publisher
[do] DOI:10.3892/ijmm.2018.3529

  9 / 6270 MEDLINE  
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[PMID]: 29509997
[Au] Autor:Bae JM; Jung YS; Jung HM; Park JH; Hann SK
[Ad] Address:Department of Dermatology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
[Ti] Title:Classification of facial vitiligo: A cluster analysis of 473 patients.
[So] Source:Pigment Cell Melanoma Res;, 2018 Mar 06.
[Is] ISSN:1755-148X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Vitiligo has a substantial negative impact on quality of life in affected patients, especially those with involvement of the face. However, the current system can barely distinguish between specific patterns of facial involvement except for the segmental type when focusing only on facial lesions. We classified facial vitiligo into three distinct subtypes using cluster analysis based on facial topography (n = 473): centrofacial vitiligo (72.9%), panfacial vitiligo (18.0%), and hairline vitiligo (9.1%). Centrofacial vitiligo was the most common type and is thought to comprise the typical facial involvement of generalized vitiligo. Panfacial vitiligo was a distinct subtype with onset in old age and less involvement of other body parts. Hairline vitiligo was another distinct subtype with onset in old age and a poor response to conventional phototherapy. A relevant classification system could help us to explore the causes, anticipate the prognosis, and manage the condition in vitiligo patients. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:Publisher
[do] DOI:10.1111/pcmr.12699

  10 / 6270 MEDLINE  
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[PMID]: 29509822
[Au] Autor:Abubucker S; Cohen B
[Ad] Address:University of Hawaii, Honolulu, HI, USA. Email: sabubuck@hawaii.edu.
[Ti] Title:Depigmented plaques on vulva.
[So] Source:J Fam Pract;67(3):171-174, 2018 Mar.
[Is] ISSN:1533-7294
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:A mother brought her 8-year-old daughter to our office for evaluation of vitiligo "down there". The skin eruption first appeared on her vulva a year earlier and was intermittently pruritic. The lesions were initially smaller and red, but had since lightened in color, coalesced, and had begun to spread to the perianal area. The patient's mother had received a call from her daughter's teacher who observed that her daughter was scratching the area and might be masturbating in class. WHAT IS YOUR DIAGNOSIS? HOW WOULD YOU TREAT THIS PATIENT?
[Pt] Publication type:CASE REPORTS
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:In-Data-Review


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