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[PMID]: 29345352
[Au] Autor:Song D; Cao Z; Huang S; Tickner J; Li N; Qiu H; Chen X; Wang C; Chen K; Sun Y; Dong S; Xu J
[Ad] Address:Department of Microbiology, Research Centre for Regenerative Medicine, Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Nanning, Guangxi, China.
[Ti] Title:Achyranthes bidentata polysaccharide suppresses osteoclastogenesis and bone resorption via inhibiting RANKL signaling.
[So] Source:J Cell Biochem;, 2018 Jan 18.
[Is] ISSN:1097-4644
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Osteoclasts are highly differentiated multinucleated giant cells that play fundamental roles in bone resorption and in the pathogenesis of osteolytic conditions, such as osteoporosis and cancer-induced bone loss. Achyranthes bidentata polysaccharide (ABP) is a hydrophilic compound with anti-oxidation and anti-aging characteristics. The impact of ABP on RANKL-induced osteoclast formation and bone resorption has not been assessed, hence, in this study we investigated the effect of ABP on osteoclast formation and resorption in murine bone marrow derived osteoclasts. We found that ABP was able to suppress RANKL-induced osteoclast differentiation and bone resorption activity at concentrations above 6.5 µM, while demonstrating no cytotoxicity at concentrations up to 10 µM. The actions of ABP were mediated through inhibition of RANKL-induced c-Fos and NFATc1 gene and protein expression. Furthermore, we found that ABP suppressed NFATc1 transcriptional activity, and the phosphorylation of MAPK pathways induced by RANKL. Collectively, ABP attenuates RANKL-mediated osteoclast activity and signaling, and might serve as a potential therapeutic candidate for preventing bone loss related diseases.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1002/jcb.26682

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[PMID]: 29410058
[Au] Autor:Zhang M; Wang Y; Zhang Q; Wang C; Zhang D; Wan JB; Yan C
[Ad] Address:School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China; Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM, PR China; Engineering & Technology Research Center for Chinese Materia Medica Quality of the Universities of
[Ti] Title:UPLC/Q-TOF-MS-based metabolomics study of the anti-osteoporosis effects of Achyranthes bidentata polysaccharides in ovariectomized rats.
[So] Source:Int J Biol Macromol;112:433-441, 2018 Feb 01.
[Is] ISSN:1879-0003
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Osteoporosis is a frequent disease among the elderly especially in postmenopausal women. Achyranthes bidentata is a traditional Chinese medicine used to strengthen bones. Here, A. bidentata polysaccharides (ABPs) were confirmed to have anti-osteoporosis effects. This study discovered biomarkers by comparing normal and osteoporosis rats and evaluated the effects of ABPs on osteoporosis based on the UPLC/Q-TOF-MS-based metabolomics analysis. We could then predict the underlying mechanisms from the perspective of metabolomics. Osteoporotic rats were treated with ABPs, and serum was then sampled for metabolic analysis. Glutarylcarnitine, lysoPC (18:1) and 9-cis-retinoic acid were identified as biomarkers. The ABPs could significantly increase these biomarkers, and this indicated that ABPs curing osteoporosis regulated lipid metabolism. The UPLC/Q-TOF-MS-based metabolomics analysis offered a potential strategy to evaluate the anti-osteoporosis effects of ABPs and to explain the relative mechanisms. Furthermore, the ABPs have good potential for treating osteoporosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180217
[Lr] Last revision date:180217
[St] Status:Publisher

  3 / 316 MEDLINE  
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[PMID]: 29331795
[Au] Autor:Tao Y; Du Y; Li W; Cai B
[Ad] Address:School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Jiangsu Key Laboratory of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address: taoyi1985812@126.com.
[Ti] Title:Development and validation of an UHPLC-MS/MS approach for simultaneous quantification of five bioactive saponins in rat plasma: Application to a comparative pharmacokinetic study of aqueous extracts of raw and salt-processed Achyranthes bidentata.
[So] Source:J Pharm Biomed Anal;151:164-169, 2018 Mar 20.
[Is] ISSN:1873-264X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:A simple, accurate and sensitive ultra high-performance liquid chromatography-tandem mass spectrometry approach was established for the simultaneous determination of ß-ecdysterone, 25S-inokosterone, ginsenoside Ro, chikusetsusaponin IV and chikusetsusaponin IVa in rat plasma after oral administration of raw and salt-processed Achyranthes bidentata extract. The saponins were completely separated on a Waters BEH C UHPLC column by using acetonitrile/0.1% formic acid-water as mobile phases. The mass analysis was performed in a triple quadrupole mass spectrometer using multiple reaction monitoring (MRM) with negative scan mode. The sample preparations for protein removal were accomplished using a simple acetonitrile precipitation method. The calibration curves displayed good linearity (r > 0.9998) with the concentration ranges of 24.4-6100 ng mL , 25.6-6400 ng mL , 20.4-8500 ng mL , 21.6-5400 ng mL , 21.6-6100 ng mL for the five saponins, respectively. The intra-day and inter-day precisions (RSD) of the five saponins were less than 3.95% and the bias of the accuracies ranged from -4.50% to 4.84%. The extraction recoveries of the five saponins ranged from 95.2% to 104.8% and the matrix effects were satisfactory. In comparison with the raw group, the parameters of C and AUC of ß-ecdysterone, 25S-inokosterone, ginsenoside Ro, and chikusetsusaponin IVa elevated remarkably (p < 0.05) after oral delivery of the extract of salt-processed Achyranthes bidentata, which revealed that salt-processing could increase bioavailability of ß-ecdysterone, 25S-inokosterone, ginsenoside Ro and chikusetsusaponin IVa.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180211
[Lr] Last revision date:180211
[St] Status:In-Process

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[PMID]: 29181847
[Au] Autor:Peng S; Wang C; Ma J; Jiang K; Jiang Y; Gu X; Sun C
[Ad] Address:Key Laboratory of Neuroregeneration of Jiangsu Province and Ministry of Education, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China.
[Ti] Title:Achyranthes bidentata polypeptide protects dopaminergic neurons from apoptosis in Parkinson's disease models both in vitro and in vivo.
[So] Source:Br J Pharmacol;175(4):631-643, 2018 02.
[Is] ISSN:1476-5381
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND AND PURPOSE: Parkinson's disease (PD) is a neurodegenerative disorder closely associated with dopaminergic neuron loss. It is well documented that Achyranthes bidentata polypeptides (ABPP) are potent neuroprotective agents in several kinds of neurons. Therefore, we proposed that ABPP might play a beneficial role against PD by protecting dopaminergic neurons from apoptosis. EXPERIMENTAL APPROACH: SH-SY5Y cells and primary rat dopaminergic neurons were pretreated with ABPP fraction k (ABPPk), a purified fraction of ABPP, and then the cells were exposed to 1-methyl-4-phenylpyridinium iodide (MPP ) to induce apoptosis. Cell viability, LDH activity, a Tunel assay and protein levels of Bcl-2 and Bax were analysed. In an in vivo PD model induced by MPTP, ABPPk was intranasally delivered to mice. Behavioural tests, immunohistochemistry, immunostaining, Nissl staining, qRT-PCR and Western blot were employed to evaluate the potential effects of ABPPk on PD in mice. KEY RESULTS: The application of ABPPk markedly enhanced the viability of SH-SY5Y cells and primary dopaminergic neurons treated with neurotoxic agent MPP . In an in vivo MPTP-induced PD model, ABPPk significantly improved behavioural performances and prevented tyrosine hydroxylase loss in the substantia nigra pars compacta and striatum. Furthermore, we showed that MPTP-induced astrocyte and microglia activation were largely attenuated by ABPPk, leading to low levels of neuroinflammation and a downregulation of the apoptotic signalling pathway. CONCLUSION AND IMPLICATIONS: Taken together, our data show that ABPPk protects dopaminergic neurons from apoptosis, suggesting that ABPPk might be an effective intervention for treating the neuron loss associated with disorders such as PD.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1711
[Cu] Class update date: 180211
[Lr] Last revision date:180211
[St] Status:In-Process
[do] DOI:10.1111/bph.14110

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[PMID]: 29352921
[Au] Autor:Zhang S; Zhang Q; Zhang D; Wang C; Yan C
[Ad] Address:School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM, China; Engineering & Technology Research Center for Chinese Materia Medica Quality of the Universities of Guang
[Ti] Title:Anti-osteoporosis activity of a novel Achyranthes bidentata polysaccharide via stimulating bone formation.
[So] Source:Carbohydr Polym;184:288-298, 2018 Mar 15.
[Is] ISSN:1879-1344
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Achyranthes bidentata is an important Traditional Chinese Medicine for the treatment of osteoporosis. In this study, A. bidentata polysaccharide (ABPB), which was extracted with alkali from the root of A. bidentata at room temperature, significantly increased the bone mineral density, bone mineral content, trabecular thickness, trabecular number and biomechanical properties of ovariectomized (OVX) rats, indicating that ABPB had prominent curative effects on osteoporosis in OVX rats. A novel polysaccharide (ABPB-3) was purified from ABPB, and its structure was characterized as a repeating unit consisting of →4)-α-d-GalpA-(1→, →2,4)-α-l-Rhap-(1→, →5)-α-l-Araf-(1→, →2,3,5)-α-l-Araf-(1→, →3)-ß-d-Galp-(1→, →3,4,6)-ß-d-Galp-(1→, terminated with α-l-Araf, α-l-Rhap and ß-d-Galp. Up to now, there were no literature reports relevant to the structure of ABPB-3. In the zebrafish model of glucocorticoid-induced osteoporosis (GIOP), ABPB-3 significantly increased the relative fluorescence intensity of the skull bone mass in a concentration-dependent manner, indicating that it stimulated bone formation activity. Thus, ABPB and ABPB-3 have the potential to be used for the anti-osteoporosis medicine.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180121
[Lr] Last revision date:180121
[St] Status:In-Process

  6 / 316 MEDLINE  
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[PMID]: 29344683
[Au] Autor:Yang YH; Li MJ; Yi YJ; Li RF; Dong C; Zhang ZY
[Ad] Address:College of Bioengineering, Henan University of Technology, Lianhua Street 100, Zhengzhou High-technology Zero, Zhengzhou, 450001, Henan, China. yyhui2004@126.com.
[Ti] Title:The root transcriptome of Achyranthes bidentata and the identification of the genes involved in the replanting benefit.
[So] Source:Plant Cell Rep;, 2018 Jan 17.
[Is] ISSN:1432-203X
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:KEY MESSAGE: The transcriptome profiling in replanting roots revealed that expression pattern changes of key genes promoted important metabolism pathways, antioxidant and pathogen defense systems, adjusted phytohormone signaling and inhibited lignin biosynthesis. The yield of the medicinal plant Achyranthes bidentata could be significantly increased when replanted into a field cultivated previously for the same crop, but the biological basis of this so-called "replanting benefit" is unknown. Here, the RNA-seq technique was used to identify candidate genes responsible for the benefit. The analysis of RNA-seq libraries prepared from mRNA extracted from the roots of first year planting (normal growth, NG) and second year replanting (consecutive monoculture, CM) yielded about 40.22 GB sequencing data. After de novo assembly, 87,256 unigenes were generated with an average length of 1060 bp. Among these unigenes, 55,604 were annotated with public databases, and 52,346 encoding sequences and 2881 transcription factors were identified. A contrast between the NG and CM libraries resulted in a set of 3899 differentially transcribed genes (DTGs). The DTGs related to the replanting benefit and their expression profiles were further analyzed by bioinformatics and qRT-PCR approaches. The major differences between the NG and CM transcriptomes included genes encoding products involved in glycolysis/gluconeogenesis, glutathione metabolism and antioxidant defense, in aspects of the plant/pathogen interaction, phytohormone signaling and phenylpropanoid biosynthesis. The indication was that replanting material enjoyed a stronger level of defense systems, a balance regulation of hormone signals and a suppression of lignin formation, thereby promoting root growth and development. The study provides considerable significant insights for a better understanding of the molecular mechanism of the replanting benefit and suggests their possible application in developing methods to reinforce the effects in medicinal plants.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180118
[Lr] Last revision date:180118
[St] Status:Publisher
[do] DOI:10.1007/s00299-018-2255-z

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[PMID]: 29256630
[Au] Autor:Goel RK; Gawande DY; Lagunin AA; Poroikov VV
[Ad] Address:a Punjabi University , Patiala , Punjab , India.
[Ti] Title:Pharmacological repositioning of Achyranthes aspera as an antidepressant using pharmacoinformatic tools PASS and PharmaExpert: a case study with wet lab validation.
[So] Source:SAR QSAR Environ Res;29(1):69-81, 2018 Jan.
[Is] ISSN:1029-046X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Traditional knowledge guides the use of plants for restricted therapeutic indications, but their pharmacological actions may be found beyond their ethnic therapeutic indications employing emerging computational tools. In this context, the present study was envisaged to explore the novel pharmacological effect of Achyranthes aspera (A. aspera) using PASS and PharmaExpert software tools. Based on the predicted mechanisms of the antidepressant effect for all analysed phytoconstituents of A. aspera, one may suggest its significant antidepressant action. The possible mechanism of this novel pharmacological effect is the enhancement of serotonin release, in particular caused by hexatriacontane. Therefore, pharmacological validation of the methanolic extract, hexatriacontane rich (HRF) and hexatriacontane lacking fraction (HLF) of A. aspera was carried out using the Forced Swimming Test and Tail suspension test in mice. The cortical and hippocampal monoamine and their metabolite levels were measured using high performance liquid chromatography (HPLC). A. aspera methanolic extract, HRF treatments showed a significant antidepressant effect comparable to imipramine. Further, the corresponding surge in cortical and hippocampal monoamine and their metabolite levels was also observed with these treatments. In conclusion, A. aspera has shown a significant antidepressant effect, possibly due to hexatriacontane, by raising monoamine levels.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180105
[Lr] Last revision date:180105
[St] Status:In-Process
[do] DOI:10.1080/1062936X.2017.1408683

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[PMID]: 29157913
[Au] Autor:Ou N; Sun Y; Zhou S; Gu P; Liu Z; Bo R; Hu Y; Liu J; Wang D
[Ad] Address:Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, PR China.
[Ti] Title:Evaluation of optimum conditions for Achyranthes bidentata polysaccharides encapsulated in cubosomes and immunological activity in vitro.
[So] Source:Int J Biol Macromol;, 2017 Nov 17.
[Is] ISSN:1879-0003
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Cubosomes, as biocompatible carriers in drug delivery systems, consist of curved bicontinuous lipid bilayers. With a honeycombed structure divided into two internal aqueous channels, cubosomes could be used for many bioactive ingredients. Achyranthes bidentata polysaccharides (ABPs) are isolated from the roots of Achyranthes bidentata, used in Chinese herbal medicine, and present a noticeable effect as an immunomodulator. This study investigates the optimal preparation of combined cubosome-ABP (Cub-ABP) nanoparticles using response surface methodology and explores their characteristics and stability. The encapsulation efficiency of optimized Cub-ABPs was 72.59%. In-vitro stability studies demonstrated the stability of Cub-ABPs and cubosome nanoparticles without ABPs; both were stable for up to 25 days. Safe concentrations of Cub-ABPs and cubosome nanoparticles without ABPs are 104.06µg/mL and 208.13µg/mL with comparatively low cytotoxicity against lymphocytes. Moreover, the feasible immunomodulatory effects of Cub-ABPs were determined by evaluating their proliferation and change of CD4 /CD8 ratio on splenic lymphocytes in vitro. Proliferation and flow cytometry studies revealed that, compared with free ABPs and blank cubosomes, Cub-ABPs proved more effective in promoting lymphocyte proliferation and in triggering the transformation of T-lymphocytes into T -cells.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171121
[Lr] Last revision date:171121
[St] Status:Publisher

  9 / 316 MEDLINE  
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[PMID]: 29114143
[Au] Autor:Sharma A; Kumar S; Tripathi P
[Ad] Address:School of Sciences, Indira Gandhi National Open University, Maidan Garhi, New Delhi, 110068 India.
[Ti] Title:Assessment of induced toxicity and molecular analysis of RAPD-PCR profiles of larval genomic DNA of L. (Diptera: Culicidae).
[So] Source:J Parasit Dis;41(4):1066-1073, 2017 Dec.
[Is] ISSN:0971-7196
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:Current studies investigated the anti-mosquito potential of against the dengue vector, The stems and leaves of were extracted in hexane and evaluated for their toxicity against early fourth instars of . The larvicidal efficacy of the extract was validated as per WHO protocol. The mortality counts were made after 24 h and LC values were calculated at different levels. The adverse impact of extracts was also explored on the larval genomic DNA. The larvae were exposed to extracts at LC levels and the alterations in -DNA was evaluated through RAPD-PCR technique using three random primers; MA-09, MA-12 and MA-26. Our investigations ascertained the larvicidal efficacy of both the leaf and stem extracts of resulting in respective LC values of 0.068 and 0.082 mg/mL. The extracts also caused variable genotoxic effects with significant changes in the RAPD profiles. The results showed appreciable modifications in larval -DNA with loss of certain bands and gain of unique bands with 82.35% DNA polymorphism. These alterations suggest the probable DNA damage and mutations in the larval -DNA caused by certain phytocomponents which could be the possible reason of larval mortality. Our studies evidenced the anti-mosquito potential of extracts against causing appreciable larval mortality and significant changes in -DNA. The extracts are suggested as efficient and eco-friendly control agent against , yet further investigations are needed to identify the bioactive constituent and ascertain its effectiveness in the field conditions.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171110
[Lr] Last revision date:171110
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1007/s12639-017-0935-1

  10 / 316 MEDLINE  
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[PMID]: 29032768
[Au] Autor:Mandefro B; Mereta ST; Tariku Y; Ambelu A
[Ad] Address:Department of Environmental Health Science and Technology, College of Public Health, Jimma University, P.O. Box 378, Jimma, Ethiopia. belayhunmandefro@gmail.com.
[Ti] Title:Molluscicidal effect of Achyranthes aspera L. (Amaranthaceae) aqueous extract on adult snails of Biomphalaria pfeifferi and Lymnaea natalensis.
[So] Source:Infect Dis Poverty;6(1):133, 2017 Oct 16.
[Is] ISSN:2049-9957
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Intestinal schistosomiasis caused by Schistosoma mansoni is a wide spread disease in most parts of Ethiopian highlands. Snail control is one major strategy in schistosomiasis control. The use of molluscicidal plant products is becoming interesting due to their environmental friendliness, accessibility and easy application. This research is aimed to evaluate the molluscicidal effect of Achyranthes aspera on Biomphalaria pfeifferi and Lymnaea natalensis snails, which are of great medical and veterinary importance in Ethiopia. METHODS: Adult B. pfeifferi snails were exposed to the various concentrations of A. aspera aqueous leaf extract for 24, 48 and 72 h. Similarly, adult L. natalensis snails were exposed to the extract for 24 h. Mortality data were analyzed using probit regression model. Phytochemical content of the plant was analyzed using standard screening methods. RESULTS: The plant's molluscicidal effect on the two snail species was demonstrated. The 24 h LC and LC values against L. natalensis were 69.5 and 93.9 ppm respectively. In the 24, 48 and 72 h exposure of B. pfeifferi, the LC values were 72.4, 69.9, 64.7 ppm and the LC were 96.5, 93.8, 92.8 ppm, respectively. The phytochemical screening tests indicated presence of saponins. CONCLUSION: From the findings of this study, A. aspera has a molluscicidal potential. The result provides a useful foundation for further in-depth studies to ensure its wider applicability in different water bodies and evaluate its toxic effects on non-target species.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171019
[Lr] Last revision date:171019
[St] Status:In-Process
[do] DOI:10.1186/s40249-017-0349-4


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