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[PMID]: 29078756
[Au] Autor:Hering R; Kreyer S; Putensen C
[Ad] Address:Department of Anesthesia and Intensive Care Medicine, University Hospital of Bonn, Bonn, Germany. Rudolf.Hering@ukb.uni-bonn.de.
[Ti] Title:Effects of lung protective mechanical ventilation associated with permissive respiratory acidosis on regional extra-pulmonary blood flow in experimental ARDS.
[So] Source:BMC Anesthesiol;17(1):149, 2017 Oct 27.
[Is] ISSN:1471-2253
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Lung protective mechanical ventilation with limited peak inspiratory pressure has been shown to affect cardiac output in patients with ARDS. However, little is known about the impact of lung protective mechanical ventilation on regional perfusion, especially when associated with moderate permissive respiratory acidosis. We hypothesized that lung protective mechanical ventilation with limited peak inspiratory pressure and moderate respiratory acidosis results in an increased cardiac output but unequal distribution of blood flow to the different organs of pigs with oleic-acid induced ARDS. METHODS: Twelve pigs were enrolled, 3 died during instrumentation and induction of lung injury. Thus, 9 animals received pressure controlled mechanical ventilation with a PEEP of 5 cmH O and limited peak inspiratory pressure (17 ± 4 cmH O) versus increased peak inspiratory pressure (23 ± 6 cmH O) in a crossover-randomized design and were analyzed. The sequence of limited versus increased peak inspiratory pressure was randomized using sealed envelopes. Systemic and regional hemodynamics were determined by double indicator dilution technique and colored microspheres, respectively. The paired student t-test and the Wilcoxon test were used to compare normally and not normally distributed data, respectively. RESULTS: Mechanical ventilation with limited inspiratory pressure resulted in moderate hypercapnia and respiratory acidosis (PaCO 71 ± 12 vs. 46 ± 9 mmHg, and pH 7.27 ± 0.05 vs. 7.38 ± 0.04, p < 0.001, respectively), increased cardiac output (140 ± 32 vs. 110 ± 22 ml/min/kg, p<0.05) and regional blood flow in the myocardium, brain and spinal cord, adrenal and thyroid glands, the mucosal layers of the esophagus and jejunum, the muscularis layers of the esophagus and duodenum, and the gall and urinary bladders. Perfusion of kidneys, pancreas, spleen, hepatic arterial bed, and the mucosal and muscularis blood flow to the other evaluated intestinal regions remained unchanged. CONCLUSIONS: In this porcine model of ARDS mechanical ventilation with limited peak inspiratory pressure resulting in moderate respiratory acidosis was associated with an increase in cardiac output. However, the better systemic blood flow was not uniformly directed to the different organs. This observation may be of clinical interest in patients, e.g. with cardiac, renal and cerebral pathologies.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171102
[Lr] Last revision date:171102
[St] Status:In-Process
[do] DOI:10.1186/s12871-017-0439-7

  2 / 43832 MEDLINE  
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[PMID]: 29065362
[Au] Autor:Surkin PN; Gallino SL; Luce V; Correa F; Fernandez Solari J; De Laurentiis A
[Ad] Address:Cátedra de Fisiología, Facultad de Odontología, Universidad de Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina.
[Ti] Title:Pharmacological augmentation of endocannabinoid signaling reduces the neuroendocrine response to stress.
[So] Source:Psychoneuroendocrinology;87:131-140, 2017 Oct 18.
[Is] ISSN:1873-3360
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Activation of the hypothalamic-pituitary-adrenal axis (HPA) is critical for survival when the organism is exposed to a stressful stimulus. The endocannabinoid system (ECS) is currently considered an important neuromodulator involved in numerous pathophysiological processes and whose primary function is to maintain homeostasis. In the tissues constituting the HPA axis, all the components of the ECS are present and the activation of this system acts in parallel with changes in the activity of numerous neurotransmitters, including nitric oxide (NO). NO is widely distributed in the brain and adrenal glands and recent studies have shown that free radicals, and in particular NO, may play a crucial role in the regulation of stress response. Our objective was to determine the participation of the endocannabinoid and NOergic systems as probable mediators of the neuroendocrine HPA axis response to a psychophysical acute stress model in the adult male rat. Animals were pre-treated with cannabinoid receptors agonists and antagonists at central and systemic level prior to acute restraint exposure. We also performed in vitro studies incubating adrenal glands in the presence of ACTH and pharmacological compounds that modifies ECS components. Our results showed that the increase in corticosterone observed after acute restraint stress is blocked by anandamide administered at both central and peripheral level. At hypothalamic level both cannabinoid receptors (CB1 and CB2) are involved, while in the adrenal gland, anandamide has a very potent effect in suppressing ACTH-induced corticosterone release that is mainly mediated by vanilloid TRPV1 receptors. We also observed that stress significantly increased hypothalamic mRNA levels of CB1 as well as adrenal mRNA levels of TRPV1 receptor. In addition, anandamide reduced the activity of the nitric oxide synthase enzyme during stress, indicating that the anti-stress action of endocannabinoids may involve a reduction in NO production at hypothalamic and adrenal levels. In conclusion, an endogenous cannabinoid tone maintains the HPA axis in a stable basal state, which is lost with a noxious stimulus. In this case, the ECS dampens the response to stress allowing the recovery of homeostasis. Moreover, our work further contributes to in vitro evidence for a participation of the endocannabinoid system by inhibiting corticosterone release directly at the adrenal gland level.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171103
[Lr] Last revision date:171103
[St] Status:Publisher

  3 / 43832 MEDLINE  
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[PMID]: 28920935
[Au] Autor:Prüss H; Tedeschi A; Thiriot A; Lynch L; Loughhead SM; Stutte S; Mazo IB; Kopp MA; Brommer B; Blex C; Geurtz LC; Liebscher T; Niedeggen A; Dirnagl U; Bradke F; Volz MS; DeVivo MJ; Chen Y; von Andrian UH; Schwab JM
[Ad] Address:Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School, Boston, Massachusetts, USA.
[Ti] Title:Spinal cord injury-induced immunodeficiency is mediated by a sympathetic-neuroendocrine adrenal reflex.
[So] Source:Nat Neurosci;20(11):1549-1559, 2017 Nov.
[Is] ISSN:1546-1726
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Acute spinal cord injury (SCI) causes systemic immunosuppression and life-threatening infections, thought to result from noradrenergic overactivation and excess glucocorticoid release via hypothalamus-pituitary-adrenal axis stimulation. Instead of consecutive hypothalamus-pituitary-adrenal axis activation, we report that acute SCI in mice induced suppression of serum norepinephrine and concomitant increase in cortisol, despite suppressed adrenocorticotropic hormone, indicating primary (adrenal) hypercortisolism. This neurogenic effect was more pronounced after high-thoracic level (Th1) SCI disconnecting adrenal gland innervation, compared with low-thoracic level (Th9) SCI. Prophylactic adrenalectomy completely prevented SCI-induced glucocorticoid excess and lymphocyte depletion but did not prevent pneumonia. When adrenalectomized mice were transplanted with denervated adrenal glands to restore physiologic glucocorticoid levels, the animals were completely protected from pneumonia. These findings identify a maladaptive sympathetic-neuroendocrine adrenal reflex mediating immunosuppression after SCI, implying that therapeutic normalization of the glucocorticoid and catecholamine imbalance in SCI patients could be a strategy to prevent detrimental infections.
[Mh] MeSH terms primary: Adrenal Glands/immunology
Hypothalamo-Hypophyseal System/immunology
Immune Tolerance/immunology
Pituitary-Adrenal System/immunology
Reflex/immunology
Spinal Cord Injuries/immunology
[Mh] MeSH terms secundary: Adrenal Glands/transplantation
Adrenalectomy/adverse effects
Adrenalectomy/methods
Adult
Aged
Animals
Female
Humans
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Middle Aged
Single-Blind Method
Spinal Cord Injuries/complications
Spinal Cord Injuries/surgery
Thoracic Vertebrae/injuries
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171102
[Lr] Last revision date:171102
[Js] Journal subset:IM
[Da] Date of entry for processing:170918
[St] Status:MEDLINE
[do] DOI:10.1038/nn.4643

  4 / 43832 MEDLINE  
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[PMID]: 28918446
[Au] Autor:Li H; Liu J; Feng X; Liu L; Wei G; Cao X; Li Y
[Ad] Address:Endocrinology Department, The First Affiliated Hospital of Sun Yat-sen University, Zhongshan Er Road, 58th, Guangzhou, 510080, China.
[Ti] Title:Favorable surgical outcomes of aldosterone-producing adenoma based on lateralization by CT imaging and hypokalemia: a non-AVS-based strategy.
[So] Source:Int Urol Nephrol;49(12):2151-2156, 2017 Dec.
[Is] ISSN:1573-2584
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:PURPOSE: To test the efficacy of a strategy based on CT imaging and clinical characteristics on lateralizing origin of excess aldosterone secretion in primary aldosteronism. PATIENTS AND METHODS: Consecutive patients with diagnosed primary hyperaldosteronism from June 2006 to July 2012 in our center underwent adrenal surgeries without pre-operational adrenal venous sampling (AVS) if all the three criteria were met: (1) round- or oval-shaped occupational lesion of low density after contrast enhancement with diameter >1 cm on CT scan was located in one adrenal gland; (2) unequivocally normal contralateral adrenal gland; (3) serum potassium level lower than 3.5 mmol/L. Subjects who had received operation were taken into analysis and follow-ups. RESULTS: One hundred and twenty-five patients fulfilled the criteria and were recruited into our research. One hundred and twenty-two operated patients (97.6%) experienced complete resolution of hypokalemia as well as resolution or improvement in hypertension with reduction in antihypertensive medication, while 3 patients (2.4%) failed to obtain normal kalemia and continued on spironolactone therapy. At a median of 65-month (range 21-93) follow-up of these 122 subjects, 27 patients dropped out (22.1%). The 95 responding patients reported no episodes of paralysis or confirmed hypokalemia or any supplementation of potassium. Multivariate linear correlation analysis showed that plasma potassium level was correlated inversely with tumor diameter (r = -0.258, 95% CI -0.076, -0.514, p = 0.037) and basal plasma aldosterone level (r = -0.251, 95% CI -0.040, -0.464, p = 0.042). CONCLUSIONS: Most patients with typical unilateral adrenal macroadenomas, normal contralateral glands and hypokalemia could attain favorable surgical therapeutic outcomes without pre-operational AVS lateralization.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 171103
[Lr] Last revision date:171103
[St] Status:In-Process
[do] DOI:10.1007/s11255-017-1705-9

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[PMID]: 28315498
[Au] Autor:Giliberto GL; Di Franco CA; Rovereto B
[Ad] Address:Department of Urology, University Hospital I.R.C.C.S Policlinico S. Matteo, Pavia - Italy.
[Ti] Title:Primitive neuroectodermal tumour of kidney with thrombosis of the inferior vena cava and good responsive to surgical and medical treatment: description of a case and revision of literature.
[So] Source:Urologia;:0, 2017 Mar 15.
[Is] ISSN:0391-5603
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:Primitive neuroectodermal tumour (PNET) of kidney is a rare cancer typical of young adults with few cases described in the literature. We report a case of renal PNET in a 31-year-old man who presented to our department with a computed tomographic (CT)-scan revealing a large renal mass of 20 cm, massive thrombosis of the inferior vena cava (IVC). The patient underwent radical nephrectomy with contextual retroperitoneal lymphadenectomy and resection of IVC needing Dacron prosthesis substitution. Definitive histopathological examination showed PNET of kidney infiltrating ipsilateral adrenal gland, massive cava thrombosis with infiltration of vena cava wall and one lymph nodal metastasis. Postoperative PET-scan showed metastatic lesions in bilateral adrenal glands and pancreas. The patient received chemotherapy, and currently, he is in follow-up after 26 months from first diagnosis without any sign of recurrence of disease. Kidney PNET usually is associated with poor prognosis, so, it needs an early identification and differentiation from other similar small cells tumours in order to obtain a good response to the treatments.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1703
[Cu] Class update date: 171103
[Lr] Last revision date:171103
[St] Status:Publisher

  6 / 43832 MEDLINE  
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[PMID]: 28150324
[Au] Autor:Garcia-Flores J; Cruceyra M; Cañamares M; Garicano A; Espada M; Nieto O; Tamarit I; Sainz de la Cuesta R
[Ad] Address:High-Risk Pregnancy Unit, Obstetrics & Gynecology Department, Hospital Universitario Quiron Madrid, Pozuelo de Alarcon (Madrid), Spain.
[Ti] Title:Sonographic Evaluation of Fetal Adrenal Gland in Gestational Diabetes: Relation to Fetal Growth and Maternal Biochemical Markers.
[So] Source:J Ultrasound Med;36(5):999-1007, 2017 May.
[Is] ISSN:1550-9613
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVES: To relate measurements and volume of the fetal adrenal gland in third trimester ultrasound in diabetic pregnancies (1) to birth weight; (2) to other sonographic markers of diabetic fetopathy (expected fetal weight, sectional area, and fractional volume in fetal limbs); and (3) to maternal biochemical markers of diabetes (HbA1c, leptin). METHODS: Fetal adrenal gland measurements were obtained between 32 and 34 weeks. The gland length, width, depth, and volume (by Virtual Organ Computer-Aided Analysis [VOCAL]) were measured for total gland and fetal zone. Fetal total and fat sectional area and fractional volume were obtained in arm and thigh. A maternal blood sample was obtained. Univariate and multivariate models were used to assess the associations. RESULTS: Thirty-nine diabetic pregnancies were included. Birth weight related significantly to total and fetal zone adrenal depth, and total adrenal volume in third trimester. Total adrenal length and corrected adrenal gland volume also showed a significant correlation to birth weight percentile in univariate and multivariate models. Total adrenal volume associated significantly to total and fat areas and volumes in fetal limbs. Both maternal leptin and HbA1c levels found a significant positive relation to fetal total adrenal volume and corrected adrenal gland volume. Total adrenal gland volume showed a significant association to maternal HbA1c level in multivariate model. CONCLUSIONS: An enlargement of the fetal adrenal gland may be observed in gestational diabetes, not only related to birth weight, but also to distinctive features of diabetic pregnancies, such as fat tissue fetal deposits or maternal biochemical markers.
[Mh] MeSH terms primary: Adrenal Glands/diagnostic imaging
Adrenal Glands/pathology
Birth Weight
Diabetes, Gestational/physiopathology
Fetal Development/physiology
Ultrasonography, Prenatal/methods
[Mh] MeSH terms secundary: Adrenal Glands/embryology
Adult
Female
Humans
Infant, Newborn
Organ Size
Pregnancy
Prospective Studies
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171102
[Lr] Last revision date:171102
[Js] Journal subset:IM
[Da] Date of entry for processing:170202
[St] Status:MEDLINE
[do] DOI:10.7863/ultra.16.03005

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[PMID]: 28127743
[Au] Autor:Gelsomino F; Lamberti G; Ambrosini V; Sperandi F; Agosti R; Morganti AG; Ardizzoni A
[Ad] Address: Medical Oncology Unit, Policlinico S. Orsola-Malpighi, Bologna - Italy.
[Ti] Title:Metachronous solitary metastasis to the thyroid gland from squamous cell carcinoma of the lung: a case report and literature review.
[So] Source:Tumori;:0, 2017 Jan 23.
[Is] ISSN:2038-2529
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Non-small cell lung cancer presents at an advanced stage at diagnosis in two-thirds of cases. The most frequent metastatic sites are the central nervous system, adrenal glands and bones. By contrast, the thyroid gland is an extremely rare site of dissemination. CASE DESCRIPTION: A 64-year-old Caucasian man previously treated with radiosurgery and brain metastasectomy followed by right middle lobectomy for a squamous cell lung carcinoma had a metachronous solitary metastasis to the thyroid gland, as confirmed by fine-needle aspiration cytology and open biopsy. He underwent curative radiotherapy, with an initial response. At 9 months' follow-up the tumor relapsed both in the thyroid and the lung. DISCUSSION AND CONCLUSIONS: Review of the literature confirmed that thyroid metastasis from lung cancer is very uncommon in clinical practice. No data on the role of surgery or curative radiotherapy in thyroid metastasis are available because of the lack of prospective studies addressing the impact on survival of these treatment strategies either alone or in combination. In the case described here, radical treatment with radiotherapy allowed to obtain a modest benefit in terms of relapse-free survival. A diagnosis of metastasis to the thyroid gland should be suspected in patients who present a thyroid nodule or suggestive imaging findings when there is a history of malignancy, including lung cancer. Indeed, an early diagnosis allows to pursue radical treatment that, in selected patients, could lead to long-term survival.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1701
[Cu] Class update date: 171103
[Lr] Last revision date:171103
[St] Status:Publisher

  8 / 43832 MEDLINE  
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[PMID]: 27973460
[Au] Autor:Papanastasiou L; Fountoulakis S; Vatalas IA
[Ad] Address:Department of Endocrinology and Diabetes Center, Athens General Hospital "G. Gennimatas", Athens, Greece - linapapan@yahoo.gr.
[Ti] Title:Adrenal disorders and non-alcoholic fatty liver disease.
[So] Source:Minerva Endocrinol;42(2):151-163, 2017 Jun.
[Is] ISSN:1827-1634
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the developed world and its pathogenesis is complex and multifactorial. It is considered the hepatic manifestation of the metabolic syndrome and is the leading cause of hepatic cirrhosis. This review aims to present current knowledge on the involvement of the adrenal glands in the development of NAFLD. Clinical and animal studies have shown that excess glucocorticoids (GC) have been implicated in the pathogenesis of NAFLD. Patients with NAFLD seem to have a subtle chronic activation of the hypothalamic pituitary adrenal axis leading to a state of subclinical hypercortisolism. Regulators of GC such as 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1), an enzyme that regenerates cortisol from inactive cortisone, and 5α/5ß-reductases, enzymes that increase cortisol clearance, are implicated in the development of NAFLD by amplifying local GC action. Adrenal androgen (dehydroepiandrosterone) abnormalities and increased aldosterone levels may also have a role in the development of NAFLD whereas the contribution of adrenergic signaling in NAFLD pathogenesis remains unclear.
[Mh] MeSH terms primary: Adrenal Cortex Hormones/metabolism
Adrenal Gland Diseases/complications
Non-alcoholic Fatty Liver Disease/complications
[Mh] MeSH terms secundary: Adrenal Gland Diseases/metabolism
Adrenal Gland Diseases/therapy
Animals
Humans
Non-alcoholic Fatty Liver Disease/metabolism
Non-alcoholic Fatty Liver Disease/therapy
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Adrenal Cortex Hormones)
[Em] Entry month:1711
[Cu] Class update date: 171102
[Lr] Last revision date:171102
[Js] Journal subset:IM
[Da] Date of entry for processing:161215
[St] Status:MEDLINE
[do] DOI:10.23736/S0391-1977.16.02583-9

  9 / 43832 MEDLINE  
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[PMID]: 29080770
[Au] Autor:Dubey JP; Trupkiewicz JG; Verma SK; Mowery JD; Adedoyin G; Georoff T; Grigg ME
[Ad] Address:United States Department of Agriculture, Agricultural Research Service, Animal Parasitic Diseases Laboratory, Beltsville Agricultural Research Center,Building 1001, Beltsville, MD, 20705, USA. Electronic address: jitender.dubey@ars.usda.gov.
[Ti] Title:Atypical fatal sarcocystosis associated with Sarcocystis neurona in a White-nosed coati (Nasua narica molaris).
[So] Source:Vet Parasitol;247:80-84, 2017 Nov 30.
[Is] ISSN:1873-2550
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:The protozoan parasite Sarcocystis neurona is an important cause of disease in horses (equine protozoal myeloencephalitis, EPM) and marine mammals. Isolated reports of clinical EPM-like disease have been documented in a zebra, raccoon, domestic cat, domestic dog, ferret, skunk, mink, lynx, red panda and fisher. The predominant disease is encephalomyelitis associated with schizonts in neural tissues. Here, we report highly disseminated sarcocystosis, in many tissues of a captive White-nosed coati (Nasua narica molaris). The 14year old, neutered male coati was euthanized due to progressive weakness, lethargy, and inappetence. Schizonts, including free and intracellular merozoites were detected in many cell types, and differed morphologically from S. neurona schizonts in horses. Only a few sarcocysts were seen in skeletal muscle and the myocardium. Immunohistochemically, the protozoa reacted positively to S. neurona but not to Toxoplasma gondii antibodies. Severe inflammtory disease detected in the stomach, intestine, adrenal and thyroid glands, ciliary body of eye, and urinary bladder associated with schizonts in the coati has not been reported earlier in any host with EPM. Although, a few schizonts were found in the brain, encephalitis was minimal and not the cause of clinical signs. Multilocus PCR-DNA sequencing using DNA derived from the coati lung tissue identified an S. neurona infection using the 18S, 28S and ITS-1 markers, and a novel genotype using primer pairs against antigenic surface proteins (SnSAG3, SnSAG4, SnSAG1-5-6) and microsatellite markers (MS, SN7, SN9). Although the genotype was similar to the widely distributed Type VI strain, it possessed a novel allele at SnSAG5, and a different MS combination of repeats at SN7 and SN9. Whether this severe parasitism was related to the host or the parasite needs further investigation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171029
[Lr] Last revision date:171029
[St] Status:In-Process

  10 / 43832 MEDLINE  
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[PMID]: 28766543
[Au] Autor:Magomedova AU; Fastova EA; Kovrigina AM; Obukhova TN; Skidan NI; Mangasarova YK; Vorobyev AI; Kravchenko SK
[Ad] Address:National Research Center for Hematology, Ministry of Health of Russia, Moscow, Russia.
[Ti] Title:Porazhenie kostnogo mozga pri pervichnoi mediastinal'noi V-krupnokletochnoi limfome. [Bone marrow involvement in primary mediastinal B-cell lymphoma].
[So] Source:Ter Arkh;89(7):65-68, 2017.
[Is] ISSN:0040-3660
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:Primary mediastinal large B-cell lymphoma (PMBCL) is a distinct type of large B-cell lymphoma. In this type of the disease, the neoplastic process is located in the anterior and superior mediastinum, frequently with compression of the superior vena cava and with tumor invasion into the adjacent organs and tissues: the pericardium, lung, pleura, etc. Despite the fact that in PMBCL progression, there may be involvement of extranodal organs, such as the kidney, adrenal glands, liver, and central nervous system, bone marrow (BM) injury is generally absent. Since BM injury in patients with diffuse large B-cell lymphoma is an independent poor prognostic indicator, there is reason to believe that BM involvement in PMBCL affects the prognosis. These cases may need intensified induction therapy followed by autologous hematopoietic stem cell transplantation; and BM injury should be monitored during the therapy. The paper gives reports of clinical cases of bone marrow involvement in 2 PMBCL patients treated at the National Research Center for Hematology, Ministry of Health of the Russian Federation.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 171031
[Lr] Last revision date:171031
[St] Status:In-Process
[do] DOI:10.17116/terarkh201789765-68


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