Database : MEDLINE
Search on : adrenal and medulla [Words]
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[PMID]: 29524326
[Au] Autor:Tanida M; Tao Z; Sun L; Song J; Yang W; Kuda Y; Kurata Y; Shibamoto T
[Ad] Address:Department of Physiology II, Kanazawa Medical University, Uchinada, Ishikawa, 920-0293, Japan.
[Ti] Title:Anaphylactic hypotension causes renal and adrenal sympathoexcitaion and induces c-fos in the hypothalamus and medulla oblongata: Anaphylaxis affects the brain and activates sympathetic nerves.
[So] Source:Exp Physiol;, 2018 Mar 10.
[Is] ISSN:1469-445X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:NEW FINDINGS: What is the central question of this study? Whether anaphylaxis affects sympathetic outflows to the brown adipose tissue (BAT) and adrenal grand is not known. Moreover, it is unknown whether anaphylaxis affects some brain areas in association with sympathetic regulation. What is the main finding and its importance? We showed that sympathoexcitatory responses to anaphylaxis regionally occurred in the kidney and adrenal grand, but not in the thermogenesis-related BAT. Further, anaphylactic hypotension also caused increase in c-fos immunoreactivity in the hypothalamic and medullary areas. Moreover, catecholaminergic neurons of the brain stem causes adrenal sympathoexcitation in a baroreceptor-independent manner. ABSTRACT: We previously reported that sympathetic nerve activity (SNA) to the kidney and the hind limb increases during anaphylactic hypotension in anesthetized rats. Based on this evidence, we examined effects of anaphylactic hypotension on SNA to the brown adipose tissue (BAT), and the adrenal gland and kidney in anesthetized rats. We demonstrated that adrenal and renal SNA, but not BAT-SNA, were stimulated. In addition, the effects of anaphylaxis on neural activities of the hypothalamic and medullary nuclei, which are candidates for relaying efferent SNA to the peripheral organs, were investigated via immunohistochemical staining of c-fos. Anaphylaxis increased c-fos expression in the neurons of the paraventricular nucleus (PVN) of the hypothalamus and in those of the nucleus tractus solitarius (NTS) and rostral ventrolateral medulla (RVLM) of the medulla oblongata; c-fos was expressed in gamma-aminobutyric acid (GABA)-ergic neurons of the NTS and in the catecholaminergic neurons of the RVLM. In addition, c-fos expression in the rostral NTS and mid NTS during anaphylaxis were reduced by sinoaortic baroreceptor denervation, however increased c-fos expression in the caudal NTS and RVLM or adrenal sympathoexcitation were not affected by sinoaortic baroreceptor denervation. These results indicated that anaphylactic hypotension activates the hypothalamic PVN, and the medullary NTS and RVLM, independently of the baroreflex pathway. Further, it stimulated efferent SNA to the adrenal grand and kidney to restore blood pressure. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher
[do] DOI:10.1113/EP086809

  2 / 12394 MEDLINE  
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[PMID]: 29516589
[Au] Autor:de Bellard ME; Ortega B; Sao S; Kim L; Herman J; Zuhdi N
[Ad] Address:California State University Northridge, Biology Dept., MC 8303., 18111 Nordhoff Street., Northridge, CA 91330.
[Ti] Title:Neuregulin-1 is a chemoattractant and chemokinetic molecule for trunk neural crest cells.
[So] Source:Dev Dyn;, 2018 Mar 08.
[Is] ISSN:1097-0177
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Trunk neural crest cells migrate rapidly along characteristic pathways within the developing vertebrate embryo. Proper trunk neural crest cell migration is necessary for the morphogenesis of much of the peripheral nervous system, melanocytes, and the adrenal medulla. Numerous molecules help guide trunk neural crest cell migration throughout the early embryo. RESULTS: Here, we show that the trophic factor NRG1 is a chemoattractant through in vitro chemotaxis assays and in vivo silencing via a DN-erbB receptor. Interestingly, we also observed changes in migratory responses consistent with a chemokinetic effect of NRG1 in trunk neural crest velocity. CONCLUSIONS: NRG1 is a trunk neural crest cell chemoattractant and chemokinetic molecule. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1002/dvdy.24625

  3 / 12394 MEDLINE  
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[PMID]: 29513786
[Au] Autor:Yanik F; Karamustafaoglu YA; Yoruk Y
[Ad] Address:MD. Assistant Professor, Department of Thoracic Surgery, Trakya Üniversitesi Tip Fakültesi, Edirne, Turkey.
[Ti] Title:A rare mediastinal occurrence of neuroblastoma in an adult: case report.
[So] Source:Sao Paulo Med J;:0, 2018 Mar 05.
[Is] ISSN:1806-9460
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:CONTEXT: Neuroblastoma is the most common extracranial malignant solid tumor that occurs during childhood. It arises from primitive cells and is seen in the adrenal medulla and sympathetic ganglia of the sympathetic nervous system. CASE REPORT: We present a rare case of a 40-year-old man who was diagnosed with the onset of neuroblastoma arising in the mediastinum. He was treated by means of surgical resection in the superior mediastinum after neoadjuvant chemotherapy. The patient's surgical outcome was satisfactory. CONCLUSION: There are still no standard treatment guidelines for adult neuroblastoma patients. Although they have a poor prognosis, the main treatment option should be complete surgery at an early stage. This situation may become clarified through biological and genetic studies in the future.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:Publisher

  4 / 12394 MEDLINE  
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[PMID]: 29409060
[Au] Autor:Tevosian SG; Ghayee HK
[Ad] Address:Department of Physiological Sciences, University of Florida.
[Ti] Title:Pheochromocytoma/Paraganglioma: A Poster Child for Cancer Metabolism.
[So] Source:J Clin Endocrinol Metab;, 2018 Feb 01.
[Is] ISSN:1945-7197
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Context: Pheochromocytomas (PCCs) are tumors that are derived from the chromaffin cells of the adrenal medulla. Extra-adrenal PCCs called paragangliomas (PGLs) are derived from the sympathetic and parasympathetic chain ganglia. PCCs secrete catecholamines which cause hypertension and have adverse cardiovascular consequences as a result of catecholamine excess. PGLs may or may not produce catecholamines depending on their genetic type and anatomical location. The most worrisome aspect of these tumors is their ability to become aggressive and metastasize, for which there are no known cures. Methods: Original articles and reviews indexed in PubMed were identified by querying with specific PCC/PGL and Krebs Cycle pathway-related terms. Additional references were selected through the in depth analysis of the relevant publications. Results: In this review, we primarily discussed Krebs Cycle mutations that can be instrumental in helping investigators to identify key biological pathways and molecules that may serve as biomarkers or treatment targets. Conclusions: The mainstay of treatment for patients with PCC/PGLs is surgical. However, the tide may be turning with the discovery of new genes associated with PCC/PGLs that may shed light on oncometabolites utilized by these tumors.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1210/jc.2017-01991

  5 / 12394 MEDLINE  
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[PMID]: 29406048
[Au] Autor:Chaaya G; Morales J; Castiglioni A; Subhani N; Asmar A
[Ad] Address:University of Central Florida College of Medicine, Orlando, Florida.
[Ti] Title:Paraganglioma of the Urinary Bladder: A Rare Cause of Hypertension and Urinary Tract Infections.
[So] Source:Am J Med Sci;355(2):191-194, 2018 Feb.
[Is] ISSN:1538-2990
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Pheochromocytoma is a neoplasm, which develops from cells of the chromaffin tissues that are derived from the ectodermic neural system and mostly situated within the adrenal medulla. Approximately 15% of pheochromocytoma cases arise from extra-adrenal chromaffin tissue. Pheochromocytoma of the bladder is rare and accounts for less than 0.06% of all bladder neoplasms and less than 1% of all pheochromocytomas. We report a case of a young woman who presented with uncontrolled hypertension, recurrent urinary tract infections and micturition attacks and was found to have a metastatic bladder paraganglioma. In addition, we provide a summary table of the clinical manifestations of paragangliomas based on anatomic locations.
[Mh] MeSH terms primary: Adrenal Gland Neoplasms
Hypertension
Urinary Bladder Neoplasms
Urinary Tract Infections
[Mh] MeSH terms secundary: Adrenal Gland Neoplasms/microbiology
Adrenal Gland Neoplasms/pathology
Adrenal Gland Neoplasms/physiopathology
Adult
Female
Humans
Hypertension/microbiology
Hypertension/pathology
Hypertension/physiopathology
Neoplasm Metastasis
Pheochromocytoma/microbiology
Pheochromocytoma/pathology
Pheochromocytoma/physiopathology
Pheochromocytoma/secondary
Urinary Bladder Neoplasms/microbiology
Urinary Bladder Neoplasms/pathology
Urinary Bladder Neoplasms/physiopathology
Urinary Tract Infections/microbiology
Urinary Tract Infections/pathology
Urinary Tract Infections/physiopathology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180207
[St] Status:MEDLINE

  6 / 12394 MEDLINE  
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[PMID]: 29370734
[Au] Autor:Tanaka M; Yasuoka A; Yoshinuma H; Saito Y; Asakura T; Tanabe S
[Ad] Address:a Nissin Global Innovation Center , Nissin Foods Holdings , Hachioji , Japan.
[Ti] Title:Seasoning ingredients in a medium-fat diet regulate lipid metabolism in peripheral tissues via the hypothalamic-pituitary axis in growing rats.
[So] Source:Biosci Biotechnol Biochem;82(3):497-506, 2018 Mar.
[Is] ISSN:1347-6947
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:We fed rats noodle (N) -diet containing 30 wt.% instant noodle with a 26% fat-to-energy ratio for 30 days (N-group). Compared with rats that were fed the same amount of nutrients (C-group), the N-group showed lower liver triacylglycerol levels and higher fecal cholesterol levels. We then analyzed transcriptome of the hypothalamic-pituitary (HP), the liver and the white adipose tissue (WAT). Thyroid stimulating hormone (Tshb), and its partner, glycoprotein hormone genes were up-regulated in the HP of N-group. Sterol regulatory element binding transcription factors were activated in the liver of N-group, while an up-regulation of the angiogenic signal occurred in the WAT of N-group. N-group showed higher urine noradrenaline (NA) level suggesting that these tissue signals are regulated by NA and Tshb. The N-diet contains 0.326 wt.% glutamate, 0.00236 wt.% 6-shogaol and Maillard reaction products. Our results suggest that these ingredients may affect lipid homeostasis via the HP axis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[St] Status:In-Process
[do] DOI:10.1080/09168451.2018.1427551

  7 / 12394 MEDLINE  
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[PMID]: 29460135
[Au] Autor:Koh YK; Kim KH; Choi MS; Koh YY; Lim DY
[Ad] Address:Department of Pediatrics, College of Medicine, Chosun University, Kwangju, 61453, Korea.
[Ti] Title:Simvastatin reduces adrenal catecholamine secretion evoked by stimulation of cholinergic nicotinic and angiotensinergic AT receptors.
[So] Source:Arch Pharm Res;, 2018 Feb 19.
[Is] ISSN:0253-6269
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:We investigated the influence of simvastatin, a statin, on the secretion of catecholamines (CA) in rat adrenal glands, and clarified its action mechanism. Simvastatin suppressed acetylcholine (ACh)-evoked CA release in a dose- and time-dependent fashion. In the presence of simvastatin, CA secretion evoked by 1.1-dimethyl-4-phenyl piperazinium iodide (DMPP), angiotensin II, high K , veratridine, and Bay-K-8644 was time-dependently inhibited. However, in the simultaneous presence of simvastatin and Nω-nitro-L-arginine methyl ester hydrochloride, CA secretion evoked by angiotensin II and DMPP recovered to control levels. Adrenal NO release was increased by simvastatin-treatment. Simvastatin-inhibited CA secretion was not affected by treatment with mevalonate. Pravastatin did not influence ACh-evoked CA secretion, while atorvastatin reduced it. In the simultaneous presence of simvastatin and fimasartan, ACh-induced CA release was markedly reduced compared to that of fimasartan-treatment alone. We present the first evidence that simvastatin reduces adrenal CA secretion induced by stimulation of nicotinic and AT -receptors. Simvastatin-induced inhibition seems to involve reducing the influx of both Ca and Na into adrenochromaffin cells, partly via the elevation of NO production by NO synthase activation, without inhibition of 3-hydroxy-methylglutaryl coenzyme A reductase. Co-administration of simvastatin and fimasartan may be clinically helpful for the treatment of cardiovascular diseases.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180220
[Lr] Last revision date:180220
[St] Status:Publisher
[do] DOI:10.1007/s12272-018-1007-5

  8 / 12394 MEDLINE  
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[PMID]: 29453919
[Au] Autor:Khatami F; Mohammadamoli M; Tavangar SM
[Ad] Address:1Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
[Ti] Title:Genetic and epigenetic differences of benign and malignant pheochromocytomas and paragangliomas (PPGLs).
[So] Source:Endocr Regul;52(1):41-54, 2018 Jan 01.
[Is] ISSN:1210-0668
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Pheochromocytomas and paragangliomas (PPGLs) are tumors arising from the adrenal medulla and sympathetic/parasympathetic paraganglia, respectively. According to Th e Cancer Genome Atlas (TCGA), approximately 40% of PPGLs are due to germ line mutations in one of 16 susceptibility genes, and a further 30% are due to somatic alterations in at least seven main genes (VHL, EPAS1, CSDE1, MAX, HRAS, NF1, RET, and possibly KIF1B). Th e diagnosis of malignant PPGL was straight forward in most cases as it was defined as presence of PPGL in non-chromaffin tissues. Accordingly, there is an extreme need for new diagnostic marker(s) to identify tumors with malignant prospective. Th e aim of this study was to review all suggested genetic and epigenetic alterations that are remarkably different between benign and malignant PPGLs. It seems that more than two genetic mutation clusters in PPGLs and other genetic and methylation biomarkers could be targeted for malignancy discrimination in different studies.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180217
[Lr] Last revision date:180217
[St] Status:In-Data-Review

  9 / 12394 MEDLINE  
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[PMID]: 29445860
[Au] Autor:Tsubota S; Kadomatsu K
[Ad] Address:Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya, 466-8550, Japan.
[Ti] Title:Origin and initiation mechanisms of neuroblastoma.
[So] Source:Cell Tissue Res;, 2018 Feb 14.
[Is] ISSN:1432-0878
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Neuroblastoma is an embryonal malignancy that affects normal development of the adrenal medulla and paravertebral sympathetic ganglia in early childhood. Extensive studies have revealed the molecular characteristics of human neuroblastomas, including abnormalities at genome, epigenome and transcriptome levels. However, neuroblastoma initiation mechanisms and even its origin are long-standing mysteries. In this review article, we summarize the current knowledge about normal development of putative neuroblastoma sources, namely sympathoadrenal lineage of neural crest cells and Schwann cell precursors that were recently identified as the source of adrenal chromaffin cells. A plausible origin of enigmatic stage 4S neuroblastoma is also discussed. With regard to the initiation mechanisms, we review genetic abnormalities in neuroblastomas and their possible association to initiation mechanisms. We also summarize evidences of neuroblastoma initiation observed in genetically engineered animal models, in which epigenetic alterations were involved, including transcriptomic upregulation by N-Myc and downregulation by polycomb repressive complex 2. Finally, several in vitro experimental methods are proposed that hopefully will accelerate our comprehension of neuroblastoma initiation. Thus, this review summarizes the state-of-the-art knowledge about the mechanisms of neuroblastoma initiation, which is critical for developing new strategies to cure children with neuroblastoma.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1802
[Cu] Class update date: 180215
[Lr] Last revision date:180215
[St] Status:Publisher
[do] DOI:10.1007/s00441-018-2796-z

  10 / 12394 MEDLINE  
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[PMID]: 29359806
[Au] Autor:Semenza GL; Prabhakar NR
[Ad] Address:Institute for Cell Engineering, McKusick-Nathans Institute of Genetic Medicine, and Departments of Pediatrics, Medicine, Oncology, Radiation Oncology, and Biological Chemistry, the Johns Hopkins University School of Medicine, Baltimore, MD, USA.
[Ti] Title:The role of hypoxia-inducible factors in carotid body (patho) physiology.
[So] Source:J Physiol;, 2018 Jan 23.
[Is] ISSN:1469-7793
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Hypoxia-inducible factors mediate adaptive responses to reduced O availability. In patients with obstructive sleep apnoea, repeated episodes of hypoxaemia and reoxygenation (intermittent hypoxia) are sensed by the carotid body (CB). The ensuing CB chemosensory reflex activates the sympathetic nervous system and increased secretion of catecholamines by the adrenal medulla, resulting in hypertension and breathing abnormalities. In the CB, intermittent hypoxia induces the formation of reactive oxygen species (ROS) and increased intracellular Ca levels, which drive increased expression of hypoxia-inducible factor (HIF) 1α and a decrease in the levels of HIF-2α.  Intermittent hypoxia increases HIF-1α-dependent expression of Nox2, encoding the pro-oxidant enzyme NADPH oxidase 2, and decreased HIF-2α-dependent expression of Sod2, encoding the anti-oxidant enzyme superoxide dismutase 2. These changes in gene expression drive persistently elevated ROS levels in the CB, brainstem, and adrenal medulla that are required for the development of hypertension and breathing abnormalities. The ROS generated by dysregulated HIF activity in the CB results in oxidation and inhibition of haem oxygenase 2, and the resulting reduction in the levels of carbon monoxide leads to increased hydrogen sulfide production, triggering glomus cell depolarization. Thus, the pathophysiology of obstructive sleep apnoea involves the dysregulation of O -regulated transcription factors, gasotransmitters, and sympathetic outflow that affects blood pressure and breathing.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180212
[Lr] Last revision date:180212
[St] Status:Publisher
[do] DOI:10.1113/JP275696


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