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[PMID]: 29524924
[Au] Autor:Han C; Hong YC
[Ad] Address:Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
[Ti] Title:Adverse health effects of ferronickel manufacturing factory on local residents: An interrupted time series analysis.
[So] Source:Environ Int;114:288-296, 2018 Mar 07.
[Is] ISSN:1873-6750
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:The first ferronickel manufacturing factory of the Republic of Korea was opened in Gwangyang City on October, 23rd, 2008. There has been public concern regarding heavy metal dust blown from the factory and slag disposal site. Therefore, we evaluated the health impact of the ferronickel factory on Gwangyang City residents by using interrupted time series analysis. We analyzed the monthly incidence patterns of asthma, allergic rhinitis, and dermatitis in Gwangyang City residents from 2004 to 2014. Data were gathered from the National Health Insurance Service database which covers all the hospital use data of entire city residents. Seasonality adjusted quasi-Poisson regression model was used to evaluate whether the operation of the ferronickel factory was associated with the immediate changes in the monthly disease incidence patterns. We set a control region, Yeosu City, near Gwangyang City to ensure that the changes in the disease incidence were specific to Gwangyang City. We conducted sub-regional level analysis to evaluate whether the disease incidence patterns were affected by the distance from the ferronickel factory. The risk estimates after operation of the ferronickel factory showed an abrupt increase in the monthly incidence of unspecified dermatitis [RR (95% CI), 1.75 (1.17-2.60)] and vasomotor and allergic rhinitis [RR (95% CI), 1.23 (1.08-1.39)] in men, and pruritus [RR (95% CI), 1.95 (1.51-2.52)], unspecified dermatitis [RR (95% CI), 1.65 (1.04-2.60)], and vasomotor and allergic rhinitis [RR (95% CI), 1.17 (1.04-1.31)] in women. These findings were significant even after accounting for the changes of the corresponding disease incidence of the comparison city, Yeosu. The effects were greater in young children (aged 0-9) and sub-regions near the ferronickel factory. Our study suggests possible association between the operation of the ferronickel factory and an abrupt increase of pruritus, unspecific dermatitis, and vasomotor and allergic rhinitis in Gwangyang City residents.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

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[PMID]: 29524917
[Au] Autor:Cardona M; Lewis ET; Turner RM; Alkhouri H; Asha S; Mackenzie J; Perkins M; Suri S; Holdgate A; Winoto L; Chang CW; Gallego-Luxan B; McCarthy S; Kristensen MR; O'Sullivan M; Skjøt-Arkil H; Ekmann AA; Nygaard HH; Jensen JJ; Jensen RO; Pedersen JL; Breen D; Petersen JA; Jensen BN; Mogensen CB; Hillman K; Brabrand M
[Ad] Address:The Simpson Centre for Health Services Research, South Western Sydney Clinical School, The University of New South Wales, PO Box 6087, UNSW, NSW, 1466 Australia. Electronic address: magnolia.cardona@unsw.edu.au.
[Ti] Title:Efficacy of a tool to predict short-term mortality in older people presenting at emergency departments: Protocol for a multi-centre cohort study.
[So] Source:Arch Gerontol Geriatr;76:169-174, 2018 Mar 06.
[Is] ISSN:1872-6976
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:BACKGROUND: Prognostic uncertainty inhibits clinicians from initiating timely end-of-life discussions and advance care planning. This study evaluates the efficacy of the CriSTAL (Criteria for Screening and Triaging to Appropriate aLternative care) checklist in emergency departments. METHODS: Prospective cohort study of patients aged ≥65 years with any diagnosis admitted via emergency departments in ten hospitals in Australia, Denmark and Ireland. Electronic and paper clinical records will be used to extract risk factors such as nursing home residency, physiological deterioration warranting a rapid response call, personal history of active chronic disease, history of hospitalisations or intensive care unit admission in the past year, evidence of proteinuria or ECG abnormalities, and evidence of frailty to be concurrently measured with Fried Score and Clinical Frailty Scale. Patients or their informal caregivers will be contacted by telephone around three months after initial assessment to ascertain survival, self-reported health, post-discharge frailty and health service utilisation since discharge. Logistic regression and bootstrapping techniques and AUROC curves will be used to test the predictive accuracy of CriSTAL for death within 90 days of admission and in-hospital death. DISCUSSION: The CriSTAL checklist is an objective and practical tool for use in emergency departments among older patients to determine individual probability of death in the short-term. Its validation in this cohort is expected to reduce clinicians' prognostic uncertainty on the time to patients' death and encourage timely end-of-life conversations to support clinical decisions with older frail patients and their families about their imminent or future care choices.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

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[PMID]: 29524909
[Au] Autor:Gillet B; Begon M; Diger M; Berger-Vachon C; Rogowski I
[Ad] Address:Univ Lyon-Université Claude Bernard Lyon 1, Laboratoire Interuniversitaire de Biologie de la Motricité, LIBM EA7424, UFRSTAPS 27-29, Villeurbanne Cedex, France; Laboratoire de simulation et de modélisation du mouvement (S2M), Département de kinésiologie, Université de Montréal, Laval, Canada. Electr
[Ti] Title:Shoulder range of motion and strength in young competitive tennis players with and without history of shoulder problems.
[So] Source:Phys Ther Sport;31:22-28, 2018 Feb 02.
[Is] ISSN:1873-1600
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To assess the effect of a history of shoulder problems on the shoulder flexibility and strength in young competitive tennis players. DESIGN: Cross-sectional study. PARTICIPANTS: Ninety-one competitive and asymptomatic tennis players aged between 8 and 15 years old were divided into two groups according to the presence or absence of a history of shoulder problems. OUTCOME MEASURES: Glenohumeral joint ranges of motion and the strength of eight shoulder muscles were bilaterally assessed. Five agonist/antagonist muscle strength ratios were also reported. Ranges of motion, strengths and strength ratios were bilaterally compared between the two groups. RESULTS: Players with a history of shoulder problems presented a higher total arc of rotation for both glenohumeral joints (p = 0.02) and a lower external/internal glenohumeral rotator muscle strength ratio (p = 0.02) for both sides. They also presented stronger upper trapezius (p = 0.03) and dominant serratus anterior (p = 0.008) muscles than players without a history of shoulder problems. CONCLUSION: Having a history of shoulder problems may alter the balance between mobility and stability within the shoulder complex suggesting that particular attention should be given to dominant and non-dominant shoulder functions by coaches and clinicians.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

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[PMID]: 29524873
[Au] Autor:Laslett AM; Jiang H; Chikritzhs T
[Ad] Address:National Drug Research Institute, Curtin University, Bentley, Perth, 6002, Australia; Centre for Alcohol Policy Research, School of Psychology and Public Health, La Trobe University, 3086, Australia; School of Population and Global Health, University of Melbourne, 3000, Australia. Electronic address: anne-marie.laslett@curtin.edu.au.
[Ti] Title:Child injury deaths linked with adult alcohol consumption: A time series analysis.
[So] Source:Drug Alcohol Depend;185:360-366, 2018 Jan 31.
[Is] ISSN:1879-0046
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:OBJECTIVE: This paper aims to quantify the population-level associations between child injury deaths and adult (aged 15+ years) per capita alcohol consumption (PCC) and between child injury deaths and the impact of major alcohol and safety policy changes in Australia. METHODS: All child deaths due to external causes during 1910-2013, and child deaths due specifically to road crashes, assaults, suicide and other external causes, were obtained from the Australian Institute of Health and Welfare. Child (0-14 year) mortality rates were analysed in relation to PCC using an Autoregressive Integrated Moving Average model. RESULTS: A positive association between PCC and overall child external mortality was identified. The estimated coefficient was 0.326 (p = .002), indicating that a 10% decrease in PCC was associated with a 3.3% reduction in child injury mortality. A positive association was identified for road traffic and other child injury mortality, but not assault injuries. The introduction of compulsory seatbelt legislation in combination with random breath testing was associated with a reduction in overall injury and road traffic child mortality. Decreasing the legal drinking age was associated with an increase in the rate of other external-cause child mortality. CONCLUSION: Reducing PCC in Australia is likely to result in a small but significant reduction in the injury mortality rate of children aged 0-14 years.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

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[PMID]: 29524813
[Au] Autor:Wong DN; Fan W
[Ad] Address:Heart Disease Prevention Program, Division of Cardiology, University of California, Irvine, USA.
[Ti] Title:Ethnic and sex differences in E-cigarette use and relation to alcohol use in California adolescents: the California Health Interview Survey.
[So] Source:Public Health;157:147-152, 2018 Mar 07.
[Is] ISSN:1476-5616
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:OBJECTIVES: E-cigarette use is not only prevalent among adolescents but is growing at an alarming rate. This study sought to determine e-cigarette use prevalence and its relation to alcohol use as a potential gateway drug, and how this may differ by sex and ethnicity in a multi-ethnic sample of California adolescents. STUDY DESIGN: Cross-sectional survey. METHODS: We included data from 1806 adolescents (weighted to 3.0 million) aged 12-17 in the 2014 and 2015 California Health Interview Survey (CHIS) cycles. The prevalence of e-cigarette use was calculated within sex and ethnic groups and the prevalence of alcohol use according to e-cigarette use was also examined with sample weighting providing population estimates. Multiple logistic regression models were built to predict the odds of using alcohol from e-cigarette use status adjusted for sociodemographic and other characteristics. RESULTS: The prevalence of e-cigarette use was 9.1% (projected to 0.3 million) overall in California adolescents but highest in boys among non-Hispanic Whites (15.1%) and in Asian girls (13.3%). Among e-cigarette users, 61.3% of boys and 71.0% of girls reported using alcohol as well. The logistic regression odds of alcohol use, adjusted for age, ethnicity, body mass index, cigarette smoking status, socioeconomic status, parents' education level, and insurance status among e-cigarettes users (compared with non-users) was 9.2 in girls and 3.1 in boys (both P < 0.01). Asians/others, non-Hispanic whites and Hispanics were similarly at increased odds: 17.8, 5.4, and 3.0, respectively (P < 0.01 for Asians/others and for whites) of using alcohol compared with their non-e-cigarette using counterparts, respectively. CONCLUSION: Attention needs to be paid to the high prevalence of e-cigarette smoking as well as its potential as a gateway drug for alcohol drinking in adolescents, especially among girls and Asians.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  6 / 4716104 MEDLINE  
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[PMID]: 29524810
[Au] Autor:Yuan S; Yu HJ; Liu MW; Huang Y; Yang XH; Tang BW; Song Y; Cao ZK; Wu HJ; He QQ; Gasevic D
[Ad] Address:School of Health Sciences, Wuhan University, PR China.
[Ti] Title:The association of fruit and vegetable consumption with changes in weight and body mass index in Chinese adults: a cohort study.
[So] Source:Public Health;157:121-126, 2018 Mar 07.
[Is] ISSN:1476-5616
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:OBJECTIVES: Findings regarding the benefits of fruit and vegetables (FV) on weight control are inconsistent and little is known among Chinese populations. Therefore, we examined the relationship between change in FV consumption, weight, and change in body mass index (BMI) among Chinese adults, participants of the China Health and Nutrition Survey (CHNS). STUDY DESIGN: A prospective cohort study. METHODS: Two waves of CHNS conducted in 2006 and 2011 were used. Continuous FV consumption increase was considered as the exposure and changes in weight and BMI as outcomes. Change in FV consumption was categorized into quintiles. Analysis of covariance and multiple linear regression models, after controlling for potential confounders such as energy intake, physical activity, and smoking, were used to describe the relationship between change in FV consumption and change in weight and BMI. RESULTS: A total of 4357 participants aged 18-65 years were included in this study. The respective weight and BMI gains in male individuals were 1.81 kg and 0.73 kg/m in the fifth quintile of FV change relative to individuals in the first quintile (3.67 kg for weight gain and 1.48 kg/m for BMI gain). An increase in FV consumption by 100 g was associated with a 211 g weight loss (B = -2.11; 95% confidence interval [CI], -3.34, -0.89, P < 0.001) and a decrease in BMI by 0.94 kg/m (B = -0.94; 95% CI, -1.36, -0.46, P < 0.001) in men; and a 140 g weight loss (B = -0.14; 95% CI, -0.97, 0.69, P = 0.74) and a decrease in BMI by 0.29 kg/m BMI (B = -0.29; 95% CI, -0.63, 0.06, P = 0.11) in women. CONCLUSIONS: Increase in FV consumption was associated with statistically significant weight loss and decrease in BMI among Chinese men, and, although suggested, weight loss among women was not significant. Considering the protective effect of FV on human health, increasing FV consumption in the Chinese population is recommended.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  7 / 4716104 MEDLINE  
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[PMID]: 29524634
[Au] Autor:Robson E; Tweedy C; Manzanza N; Taylor JP; Atkinson P; Randall F; Reeve A; Clowry GJ; LeBeau FEN
[Ad] Address:Institute of Neuroscience, Newcastle University, Medical School, Framlington Place, Newcastle-upon-Tyne NE2 4HH, UK.
[Ti] Title:Impaired fast network oscillations and mitochondrial dysfunction in a mouse model of alpha-synucleinopathy (A30P).
[So] Source:Neuroscience;, 2018 Mar 07.
[Is] ISSN:1873-7544
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Intracellular accumulation of alpha-synuclein (α-syn) is a key pathological process evident in Lewy body dementias (LBD), including Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB). LBD results in marked cognitive impairments and changes in cortical networks. To assess the impact of abnormal α-syn expression on cortical network oscillations relevant to cognitive function, we studied changes in fast beta/gamma network oscillations in the hippocampus in a mouse line that over-expresses human mutant α-syn (A30P). We found an age-dependent reduction in the power of the gamma (20-80 Hz) frequency oscillations in slices taken from mice aged 9-16 months (9+), that was not present in either young 2-6 months old (2+) A30P mice, or in control mice at either age. The mitochondrial blockers potassium cyanide and rotenone both reduced network oscillations in a concentration-dependent manner in aged A30P mice and aged control mice but slices from A30P mice showed a greater reduction in the oscillations. Histochemical analysis showed an age-dependent reduction in cytochrome c oxidase (COX) activity, suggesting a mitochondrial dysfunction in the 9+A30P group. A deficit in COX IV expression was confirmed by immunohistochemistry. Overall, our data demonstrate an age-dependent impairment in mitochondrial function and gamma frequency activity associated with the abnormal expression of α-syn. These findings provide mechanistic insights into the consequences of over-expression of α-syn which might contribute to cognitive decline.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  8 / 4716104 MEDLINE  
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[PMID]: 29524625
[Au] Autor:Brookes MJ; Groom MJ; Liuzzi L; Hill RM; Smith HJF; Briley PM; Hall EL; Hunt BAE; Gascoyne LE; Taylor MJ; Liddle PF; Morris PG; Woolrich MW; Liddle EB
[Ad] Address:Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, NG7 2RD, United Kingdom. Electronic address: matthew.brookes@nottingham.ac.uk.
[Ti] Title:Altered temporal stability in dynamic neural networks underlies connectivity changes in neurodevelopment.
[So] Source:Neuroimage;, 2018 Mar 07.
[Is] ISSN:1095-9572
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Network connectivity is an integral feature of human brain function, and characterising its maturational trajectory is a critical step towards understanding healthy and atypical neurodevelopment. Here, we used magnetoencephalography (MEG) to investigate both stationary (i.e. time averaged) and rapidly modulating (dynamic) electrophysiological connectivity, in participants aged from mid-childhood to early adulthood (youngest participant 9 years old; oldest participant 25 years old). Stationary functional connectivity (measured via inter-regional coordination of neural oscillations) increased with age in the alpha and beta frequency bands, particularly in bilateral parietal and temporo-parietal connections. Our dynamic analysis (also applied to alpha/beta oscillations) revealed the spatiotemporal signatures of 8 dynamic networks; these modulate on a ∼100 ms time scale, and temporal stability in attentional networks was found to increase with age. Significant overlap was found between age-modulated dynamic networks and inter-regional oscillatory coordination, implying that altered network dynamics underlie age related changes in functional connectivity. Our results provide novel insights into brain network electrophysiology, and lay a foundation for future work in childhood disorders.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  9 / 4716104 MEDLINE  
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[PMID]: 29524610
[Au] Autor:Anandappa M; Adjei Boakye E; Li W; Zeng W; Rebmann T; Chang JJ
[Ad] Address:Department of Epidemiology and Biostatistics, College for Public Health and Social Justice, Saint Louis University, Saint Louis, MO, USA.
[Ti] Title:Racial disparities in vaccination for seasonal influenza in early childhood.
[So] Source:Public Health;158:1-8, 2018 Mar 07.
[Is] ISSN:1476-5616
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:OBJECTIVES: Influenza vaccination is the best protection against infection and severe complications of disease, such as hospitalization and death. Therefore, it is important to accurately estimate vaccination coverage and to evaluate the role of race/ethnicity. This study examines racial disparities in influenza vaccination among children using a nationally representative sample. STUDY DESIGN: This study used cross-sectional data from the 2009-2014 National Immunization Survey for children aged 19-35 months (n = 98,186) in the United States. METHODS: The outcome variable was receipt of influenza vaccination (yes/no) and exposure variable was race/ethnicity. Weighted multivariate logistic regression was used to estimate the odds ratio and 95% confidence intervals (CIs) for the effect of race/ethnicity on receipt of the influenza vaccine. RESULTS: The overall vaccination rates were 81.6% for non-Hispanic whites, 79.2% for Hispanics, 80.5% for non-Hispanic blacks, and 80.7% for non-Hispanic mixed/other. In the adjusted model, compared with non-Hispanic white children, Hispanic children were 13% less likely to receive influenza vaccination within the last 12 months (adjusted odds ratio [aOR] = 0.87; 95% CI: 0.80-0.94). In addition, children aged 24-29 months (aOR = 0.48; 95% CI: 0.44-0.52) and 30-35 months (aOR = 0.33; 95% CI: 0.30-0.36) were significantly less likely to receive influenza vaccination within the last 12 months compared with those who were 19-23 months old. CONCLUSIONS: There were differences in influenza vaccination rates among different racial groups. Hispanic children had the lowest vaccination rates. Findings from our study have significant implications for targeted interventions to increase the overall vaccination rate for children in the United States.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

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[PMID]: 29524590
[Au] Autor:Barnhart K; Giudice L; Young S; Thomas T; Diamond MP; Segars J; Youssef WA; Krawetz S; Santoro N; Eisenberg E; Zhang H; NICHD Cooperative Reproductive Medicine Network
[Ad] Address:Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA, United States. Electronic address: kbarnhart@obgyn.upenn.edu.
[Ti] Title:Evaluation, validation and refinement of noninvasive diagnostic biomarkers for endometriosis (ENDOmarker): A protocol to phenotype bio-specimens for discovery and validation.
[So] Source:Contemp Clin Trials;, 2018 Mar 07.
[Is] ISSN:1559-2030
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Endometriosis is a chronic, estrogen dependent condition that affects 5-10% of reproductive aged women and is associated with pelvic pain and infertility. As the approach to therapy shifts from surgical ablation to pharmacological control, a non-surgical mode of diagnosis would be desirable. The ENDOmarker study was designed by the NICHD Reproductive Medicine Network (RMN) to obtain well characterized and phenotyped bio specimens in a standardized fashion from women with and without endometriosis. DESIGN: Development of a diagnostic test. SETTING: Academic medical centers. PATIENTS: This study will enroll up to 500 participants, and follow them for up to 5 months. Included subjects are aged 18-44, scheduled to undergo gynecologic surgery (laparoscopy/laparotomy) for clinical reasons. INTERVENTIONS: Presence and stage of endometriosis (or its absence) is characterized by visual examination at the time of surgery. Subjects will undergo extensive clinical evaluation pre-operatively and at visits one and four months postoperatively. Endometrial biopsy, blood, urine and disease specific questionnaires will be collected at each visit. MAIN OUTCOME: Samples will be placed in a bio-repository to be used to validate and optimize the clinical use of genomic classifiers of the endometrium alone or in combination with serum cytokines as a non-surgical composite marker of endometriosis. CONCLUSION: This protocol can serve as a reference for objective collection of high quality bio specimens for discovery or validation of potential nonsurgical diagnosis of presence or severity of disease.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher


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