Database : MEDLINE
Search on : air [Words]
References found : 265572 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 26558 go to page                         

  1 / 265572 MEDLINE  
              next record last record
select
to print
Photocopy
PubMed Central Full text
Full text

[PMID]: 25610601
[Au] Autor:Park SH; Chen WC; Esmaeil N; Lucas B; Marsh LM; Reibman J; Grunig G
[Ad] Address:Department of Environmental Medicine, New York University School of Medicine, Tuxedo, New York, USA....
[Ti] Title:Interleukin 13- and interleukin 17A-induced pulmonary hypertension phenotype due to inhalation of antigen and fine particles from air pollution.
[So] Source:Pulm Circ;4(4):654-68, 2014 Dec.
[Is] ISSN:2045-8932
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Pulmonary hypertension has a marked detrimental effect on quality of life and life expectancy. In a mouse model of antigen-induced pulmonary arterial remodeling, we have recently shown that coexposure to urban ambient particulate matter (PM) significantly increased the thickening of the pulmonary arteries and also resulted in significantly increased right ventricular systolic pressures. Here we interrogate the mechanism and show that combined neutralization of interleukin 13 (IL-13) and IL-17A significantly ameliorated the increase in right ventricular systolic pressure, the circumferential muscularization of pulmonary arteries, and the molecular change in the right ventricle. Surprisingly, our data revealed a protective role of IL-17A for the antigen- and PM-induced severe thickening of pulmonary arteries. This protection was due to the inhibition of the effects of IL-13, which drove this response, and the expression of metalloelastase and resistin-like molecule α. However, the latter was redundant for the arterial thickening response. Anti-IL-13 exacerbated airway neutrophilia, which was due to a resulting excess effect of IL-17A, confirming concurrent cross inhibition of IL-13- and IL-17A-dependent responses in the lungs of animals exposed to antigen and PM. Our experiments also identified IL-13/IL-17A-independent molecular reprogramming in the lungs induced by exposure to antigen and PM, which indicates a risk for arterial remodeling and protection from arterial constriction. Our study points to IL-13- and IL-17A-coinduced inflammation as a new template for biomarkers and therapeutic targeting for the management of immune response-induced pulmonary hypertension.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Cu] Class update date: 150124
[Lr] Last revision date:150124
[Da] Date of entry for processing:150122
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1086/678511

  2 / 265572 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 25490891
[Au] Autor:Abaci HE; Gledhill K; Guo Z; Christiano AM; Shuler ML
[Ad] Address:Department of Biomedical Engineering, Cornell University, 115 Weill Hall, Ithaca, New York, USA. mls50@cornell.edu.
[Ti] Title:Pumpless microfluidic platform for drug testing on human skin equivalents.
[So] Source:Lab Chip;15(3):882-8, 2015 Jan 22.
[Is] ISSN:1473-0189
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Advances in bio-mimetic in vitro human skin models increase the efficiency of drug screening studies. In this study, we designed and developed a microfluidic platform that allows for long-term maintenance of full thickness human skin equivalents (HSE) which are comprised of both the epidermal and dermal compartments. The design is based on the physiologically relevant blood residence times in human skin tissue and allows for the establishment of an air-epidermal interface which is crucial for maturation and terminal differentiation of HSEs. The small scale of the design reduces the amount of culture medium and the number of cells required by 36 fold compared to conventional transwell cultures. Our HSE-on-a-chip platform has the capability to recirculate the medium at desired flow rates without the need for pump or external tube connections. We demonstrate that the platform can be used to maintain HSEs for three weeks with proliferating keratinocytes similar to conventional HSE cultures. Immunohistochemistry analyses show that the differentiation and localization of keratinocytes was successfully achieved, establishing all sub-layers of the epidermis after one week. Basal keratinocytes located at the epidermal-dermal interface remain in a proliferative state for three weeks. We use a transdermal transport model to show that the skin barrier function is maintained for three weeks. We also validate the capability of the HSE-on-a-chip platform to be used for drug testing purposes by examining the toxic effects of doxorubucin on skin cells and structure. Overall, the HSE-on-a-chip is a user-friendly and cost-effective in vitro platform for drug testing of candidate molecules for skin disorders.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Cu] Class update date: 150124
[Lr] Last revision date:150124
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1039/c4lc00999a

  3 / 265572 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
PubMed Central Full text
Full text

[PMID]: 25610508
[Au] Autor:Amaral CB; Silva S; Feijó S
[Ad] Address:Hospital de Santa Maria, Northern Lisbon Hospital Center, Department of Internal Medicine, Lisbon, Portugal. Department of Internal Medicine, Northern Lisbon Hospital Center, Hospital de Santa Maria, Lisbon, Portugal.
[Ti] Title:Infected tracheal diverticulum: a rare association with alpha-1 antitrypsin deficiency.
[So] Source:J Bras Pneumol;40(6):669-72, 2014 Nov-Dec.
[Is] ISSN:1806-3756
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:Tracheal diverticulum, defined as a benign outpouching of the tracheal wall, is rarely diagnosed in clinical practice. It can be congenital or acquired in origin, and most cases are asymptomatic, typically being diagnosed postmortem. We report a case of a 69-year-old woman who was hospitalized after presenting with fever, fatigue, pleuritic chest pain, and a right neck mass complicated by dysphagia. Her medical history was significant: pulmonary emphysema (alpha-1 antitrypsin deficiency); bronchiectasis; and thyroidectomy. On physical examination, she presented diminished breath sounds and muffled heart sounds, with a systolic murmur. Laboratory tests revealed elevated inflammatory markers, a CT scan showed an air-filled, multilocular mass in the right tracheal wall, and magnetic resonance imaging confirmed the CT findings. Fiberoptic bronchoscopy failed to reveal any abnormalities. Nevertheless, the patient was diagnosed with tracheal diverticulum. The treatment approach was conservative, consisting mainly of antibiotics. After showing clinical improvement, the patient was discharged.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Cu] Class update date: 150124
[Lr] Last revision date:150124
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1590/S1806-37132014000600011

  4 / 265572 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
PubMed Central Full text
Full text

[PMID]: 25610326
[Au] Autor:Isara AR; Aigbokhaode AQ
[Ad] Address:Department of Community Health, University of Benin Teaching Hospital, Benin City, Nigeria.
[Ti] Title:Household Cooking Fuel Use among Residents of a Sub-Urban Community in Nigeria: Implications for Indoor Air Pollution.
[So] Source:Eurasian J Med;46(3):203-8, 2014 Oct.
[Is] ISSN:1308-8734
[Cp] Country of publication:Turkey
[La] Language:eng
[Ab] Abstract:OBJECTIVE: The aim of this study is to assess the types of household cooking fuel used by residents of Isiohor community in Edo State, Nigeria. MATERIALS AND METHODS: This descriptive cross-sectional study was conducted among 133 household heads or their representatives in Isiohor Community in Edo State, Nigeria. Data collection was by means of a structured interviewer administered questionnaire. RESULTS: Half (50.3%) of the households studied were made up of 4-6 persons living in them. Sixty-two (46.6%) respondents had tertiary level of education and a third 44 (33.1%) earned between 21,000 and 30,000 naira (150-200 dollars) monthly. Forty six (34.6%) and 27 (20.3%) respondents live in passage houses and flats respectively. Two thirds (68.4%) of the respondents cook their food indoors. The predominant household cooking fuels used by the respondents were cooking gas (51.1%), Kerosene (45.9%), vegetables (25.6%) and firewood (14.3%). Majority 106 (79.7%) had poor knowledge of the health effects of prolonged exposure to smoke arising from indoor cooking. There was a statistically significant association between the occupation of the respondents and the type of household cooking fuel used (p=0.002). CONCLUSION: The use of unclean indoor cooking fuel was high among the residents of Isiohor community in Edo State, Nigeria. Also, there was poor knowledge of the health effects of prolonged exposure to smoke from unclean cooking fuel among the respondents and this has serious implications for indoor air pollution. There is an urgent need for health/hygiene education on the health effects of use of unclean indoor cooking fuel among these residents. There is also need for use of clean/green cooking stoves and construction of exhaust ventilation pipes in these households.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Cu] Class update date: 150124
[Lr] Last revision date:150124
[Da] Date of entry for processing:150122
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.5152/eajm.2014.0051

  5 / 265572 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
PubMed Central Full text
Full text

[PMID]: 25609888
[Au] Autor:Tomczak A; Gajewski J; Mazur-Rózycka J
[Ad] Address:Department of Physical Education and Sport, General Staff of the Polish Armed Forces, Warsaw, Poland.
[Ti] Title:Changes in physiological tremor resulting from sleep deprivation under conditions of increasing fatigue during prolonged military training.
[So] Source:Biol Sport;31(4):303-8, 2014 Dec.
[Is] ISSN:0860-021X
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:The aim of the study was to define the changes of the characteristics of physiological postural tremor under conditions of increasing fatigue and lack of sleep during prolonged military training (survival). The subjects of the study were 15 students of the Polish Air Force Academy in Deblin. The average age was 19.9±1.3 years. During the 36-hour-long continuous military training (survival) the subjects were deprived of sleep. Four tremor measurements were carried out for each of the subjects: Day 1 - morning, after rest (measurement 0); Day 2 - morning, after overnight physical exercise (measurement 1); afternoon, after continuous sleep deprivation (measurement 2); Day 3 - morning, after a full night sleep (measurement 3). The accelerometric method using an acceleration measuring kit was applied to analyse tremor. A significant difference between mean values of the index evaluating tremor power in low frequencies L2-4 in measurement 0 and measurement 3 was observed (p<0.01). No significant differences were found in mean values of index L10-20. Mean frequencies F2-4 differed significantly from each other (F2,42=4.53; p<0.01). Their values were 2.94±0.11, 2.99±0.9, 2.93±0.07 and 2.91±0.07 for successive measurements. A gradual, significant decrease of F8-14 was observed (F2,42=5.143; p<0.01). Prolonged sleep deprivation combined with performing tasks demanding constant physical effort causes long-lasting (over 24 hours) changes of the amplitude of low-frequency tremor changes. This phenomenon may significantly influence psychomotor performance, deteriorating the ability to perform tasks requiring movement precision.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Cu] Class update date: 150124
[Lr] Last revision date:150124
[Da] Date of entry for processing:150122
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.5604/20831862.1127343

  6 / 265572 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
PubMed Central Full text
Full text

[PMID]: 25606340
[Au] Autor:David HN; Dhilly M; Poisnel G; Degoulet M; Meckler C; Vallée N; Blatteau JÉ; Risso JJ; Lemaire M; Debruyne D; Abraini JH
[Ad] Address:Centre de recherche Hôtel-Dieu de Lévis, CSSS Alphonse-Desjardins, Lévis, QC Canada ; Département d'Anesthésiologie, Université Laval, Québec, QC Canada....
[Ti] Title:Argon prevents the development of locomotor sensitization to amphetamine and amphetamine-induced changes in mu opioid receptor in the nucleus accumbens.
[So] Source:Med Gas Res;4(1):21, 2014.
[Is] ISSN:2045-9912
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Systemic administration of γ-amino-butyric acid type A (GABA-A) and benzodiazepine receptor agonists has been reported to block the development of locomotor sensitization to amphetamine. Here, we investigated whether the non-anesthetic noble gas argon, shown to possess agonistic properties at these receptors, may block the acquisition of amphetamine-induced locomotor sensitization and mu opioid receptor activation in the nucleus accumbens. Rats were pretreated with saline solution or amphetamine (1 mg/kg) from day 1 to day 3 and then exposed, immediately after injection of amphetamine, to medicinal air or argon at 75 vol% (with the remainder being oxygen). After a 3-day period of withdrawal, rats were challenged with amphetamine on day 7. Rats pretreated with amphetamine and argon had lower locomotor activity (U = 5, P < 0.005) and mu opioid receptor activity in the nucleus accumbens (U = 0, P < 0.001) than rats pretreated with amphetamine and air. In contrast, argon had effect on locomotor and mu receptor activity neither in rats pretreated with saline and challenged with amphetamine (acute amphetamine) nor in rats pretreated and challenged with saline solution (controls). These results indicate that argon inhibits the development of both locomotor sensitization and mu opioid receptor activation induced by repeated administration of amphetamine.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Cu] Class update date: 150124
[Lr] Last revision date:150124
[Da] Date of entry for processing:150121
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1186/s13618-014-0021-z

  7 / 265572 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
PubMed Central Full text
Full text

[PMID]: 25606343
[Au] Autor:Taghizadeh S; Najmabadi H; Kamali K; Behjati F
[Ad] Address:Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran....
[Ti] Title:Evaluation of chromosomal aberrations caused by air pollutants in some taxi drivers from two polluted districts of urban Tehran and its comparison with drivers from rural areas of Lahijan: a pilot study.
[So] Source:J Environ Health Sci Eng;12(1):144, 2014.
[Is] ISSN:2052-336X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Chromosome instability is the most common form of genomic instability. Genomic instability can lead to tumorogenesis. High level of chromosomal aberrations in peripheral blood lymphocytes can be used as a biomarker for cancer. Air pollution is one of the most important factors that cause chromosomal instability (CIN). In this comparative study we used classic Cytogenetic technique to analyze the effects of air pollutants on chromosome stability. We collected peripheral blood from 30 taxi drivers of two polluted districts (districts 6 and 7) in Tehran and 30 taxi drivers from rural areas of Lahijan, north of Iran. RESULTS: Comparison of the level of chromosome breakage in the two groups showed an increased level of chromosome breakage in the drivers from polluted districts of Tehran, although not significant, using Fisher exact test (p-value = 0.300). However, the overall chromosome aberration rate (including both chromosome and chromatid gaps), the difference was significant using Chi-square test (p-value = 0.012). CONCLUSION: An increased level of chromosome aberration was present in the drivers from polluted districts of Tehran compared to drivers from non-polluted areas in Lahijan.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Cu] Class update date: 150124
[Lr] Last revision date:150124
[Da] Date of entry for processing:150121
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1186/s40201-014-0144-0

  8 / 265572 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
PubMed Central Full text
Full text

[PMID]: 25395203
[Au] Autor:Ahmed TM; Bergvall C; Åberg M; Westerholm R
[Ad] Address:Department of Analytical Chemistry, Arrhenius Laboratory, Stockholm University, 10691, Stockholm, Sweden.
[Ti] Title:Determination of oxygenated and native polycyclic aromatic hydrocarbons in urban dust and diesel particulate matter standard reference materials using pressurized liquid extraction and LC-GC/MS.
[So] Source:Anal Bioanal Chem;407(2):427-38, 2015 Jan.
[Is] ISSN:1618-2650
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:The objective of this study was to develop a novel analytical chemistry method, comprised of a coupled high-performance liquid chromatography-gas chromatography/mass spectrometry system (LC-GC/MS) with low detection limits and high selectivity, for the identification and determination of oxygenated polycyclic aromatic hydrocarbons (OPAHs) and polycyclic aromatic hydrocarbons (PAHs) in urban air and diesel particulate matter. The linear range of the four OPAHs, which include 9,10-anthraquinone, 4H-cyclopenta[def]phenanthrene-4-one, benzanthrone, and 7,12-benz[a]anthraquinone, was 0.7 pg-43.3 ng with limits of detection (LODs) and limits of quantification (LOQs) on the order of 0.2-0.8 and 0.7-1.3 pg, respectively. The LODs in this study are generally lower than values reported in the literature, which can be explained by using large-volume injection. The recoveries of the OPAHs spiked onto glass fiber filters using two different pressurized liquid extraction (PLE) methods were in the ranges of 84-107 and 67-110 %, respectively. The analytical protocols were validated using the following National Institute of Standards and Technology standard reference materials: SRM 1649a (Urban Dust), SRM 1650b (Diesel Particulate Matter), and SRM 2975 (Diesel Particulate Matter, Industrial Forklift). The measured mass fractions of the OPAHs in the standard reference materials (SRMs) in this present study are higher than the values from the literature, except for benzanthrone in SRM 1649a (Urban Dust). In addition to the OPAHs, 44 PAHs could be detected and quantified from the same particulate extract used in this protocol. Using data from the literature and applying a two-sided t test at the 5 % level using Bonferroni correction, significant differences were found between the tested PLE methods for individual PAHs. However, the measured mass fractions of the PAHs were comparable, similar to, or higher than those previously reported in the literature.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Cu] Class update date: 150124
[Lr] Last revision date:150124
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s00216-014-8304-8

  9 / 265572 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 25564451
[Au] Autor:Mukherjee S; Zhou X; Rajaiya J; Chodosh J
[Ad] Address:Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Howe Laboratory, Harvard Medical School, Boston, Massachusetts, United States....
[Ti] Title:Ultrastructure of adenovirus keratitis.
[So] Source:Invest Ophthalmol Vis Sci;56(1):472-7, 2015.
[Is] ISSN:1552-5783
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: We determined the ultrastructure of mouse adenovirus keratitis, a model for human adenovirus keratitis. METHODS: Adenovirus keratitis was induced in C57Bl/6j mice by intrastromal injection of human adenovirus species D type 37 (HAdV-D37) with a heat-pulled, glass, micropipette needle under compressed air. At select time points after infection, mice were euthanized and their corneas removed, fixed, and sectioned at 70-nm thickness for electron microscopy. RESULTS: Injection of HAdV-D37 into the mouse corneal stroma placed virus predominantly in the pericellular corneal stromal matrix. Virus was seen bound to and entering stromal cells at 1 and 2 hours after infection, respectively. Cell membrane transit by virus was seen to involve two distinct structures resembling caveolae and macropinosomes. However, later during infection intracellular virus was not seen within membrane-bound organelles. By 8 hours after infection, intracellular virus had accumulated into densely packed, perinuclear arrays. Virus disassembly was not obvious at any time point after infection. Infiltrating neutrophils seen by one day after infection had engulfed degraded stromal cells by 4 days after infection. CONCLUSIONS: By transmission electron microscopy, injected HAdV-D37 readily enters stromal cells in the C57Bl/6j mouse cornea and induces stromal inflammation, as was shown previously by light microscopy. However, electron microscopy also revealed dense, static arrays of intracytoplasmic virus, suggesting a block in viral capsid disassembly and viral DNA nuclear entry. These findings may explain why human adenoviruses do not replicate in the mouse corneal stroma.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Cu] Class update date: 150124
[Lr] Last revision date:150124
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1167/iovs.14-15635

  10 / 265572 MEDLINE  
              first record previous record
select
to print
Photocopy
PubMed Central Full text
Full text

[PMID]: 25601905
[Au] Autor:Vogiannis EG; Nikolopoulos D
[Ad] Address:Evangeliki Model School of Smyrna , Nea Smyrni , Greece.
[Ti] Title:Radon sources and associated risk in terms of exposure and dose.
[So] Source:Front Public Health;2:207, 2014.
[Is] ISSN:2296-2565
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Radon concerns the international scientific community from the early twentieth century, initially as radium emanation and nearly the second half of the century as a significant hazard to human health. The initial brilliant period of its use as medicine was followed by a period of intense concern for its health effects. Miners in Europe and later in the U.S were the primary target groups surveyed. Nowadays, there is a concrete evidence that radon and its progeny can cause lung cancer (1). Human activities may create or modify pathways increasing indoor radon concentration compared to outdoor background. These pathways can be controlled by preventive and corrective actions (2). Indoor radon and its short-lived progeny either attached on aerosol particles or free, compose an air mixture that carries a significant energy amount [Potential Alpha-Energy Concentration (PAEC)]. Prior research at that topic focused on the exposure on PAEC and the dose delivered by the human body or tissues. Special mention was made to the case of water workers due to inadequate data. Furthermore, radon risk assessment and relevant legislation for the dose delivered by man from radon and its progeny has been also reviewed.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1501
[Cu] Class update date: 150124
[Lr] Last revision date:150124
[Da] Date of entry for processing:150120
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.3389/fpubh.2014.00207


page 1 of 26558 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information