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[PMID]: 24418322
[Au] Autor:von Voigts-Rhetz P; Czarnecki D; Zink K
[Ad] Address:Institut für Medizinische Physik und Strahlenschutz - IMPS, Technische Hochschule Mittelhessen, University of Applied Sciences, Gießen, Germany. Electronic address: philip.von.voigts-rhetz@kmub.thm.de.
[Ti] Title:Effective point of measurement for parallel plate and cylindrical ion chambers in megavoltage electron beams.
[So] Source:Z Med Phys;24(3):216-23, 2014 Sep.
[Is] ISSN:1876-4436
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:The presence of an air filled ionization chamber in a surrounding medium introduces several fluence perturbations in high energy photon and electron beams which have to be accounted for. One of these perturbations, the displacement effect, may be corrected in two different ways: by a correction factor pdis or by the application of the concept of the effective point of measurement (EPOM). The latter means, that the volume averaged ionization within the chamber is not reported to the chambers reference point but to a point within the air filled cavity. Within this study the EPOM was determined for four different parallel plate and two cylindrical chambers in megavoltage electron beams using Monte Carlo simulations. The positioning of the chambers with this EPOM at the depth of measurement results in a largely depth independent residual perturbation correction, which is determined within this study for the first time. For the parallel plate chambers the EPOM is independent of the energy of the primary electrons. Whereas for the Advanced Markus chamber the position of the EPOM coincides with the chambers reference point, it is shifted for the other parallel plate chambers several tenths of millimeters downstream the beam direction into the air filled cavity. For the cylindrical chambers there is an increasing shift of the EPOM with increasing electron energy. This shift is in upstream direction, i.e. away from the chambers reference point toward the focus. For the highest electron energy the position of the calculated EPOM is in fairly good agreement with the recommendation given in common dosimetry protocols, for the smallest energy, the calculated EPOM positions deviate about 30% from this recommendation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review

  2 / 259606 MEDLINE  
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[PMID]: 25127528
[Au] Autor:Drozd M; Chandrashekhar K; Rajashekara G
[Ad] Address:Food Animal Health Research Program; Ohio Agricultural Research and Development Center; Department of Veterinary Preventive Medicine; The Ohio State University; Wooster, OH USA.
[Ti] Title:Polyphosphate-mediated modulation of Campylobacter jejuni biofilm growth and stability.
[So] Source:Virulence;5(6):680-90, 2014 Aug 15.
[Is] ISSN:2150-5608
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Biofilms increase C. jejuni's resilience to detergents, antibiotics, and environmental stressors. In these investigations, we studied the modulation of biofilm in response to phosphate related stressors. We found that the deletion of ppk1, phoX, and ppk2 (polyphosphate associated [poly P] genes) in C. jejuni modulated different stages of biofilm formation such as attached microcolonies, air-liquid biofilms, and biofilm shedding. Additionally, inorganic phosphate also modulated attached microcolonies, air-liquid biofilms, and biofilm shedding both independently of and additively in the poly P associated mutants. Furthermore, we observed that these different biofilm stages were affected by biofilm age: for example, the adherent microcolonies were maximum on day 2, while biofilm growth at the air-liquid interface and shedding was highest on day 3. Also, we observed altered calcofluor white reactive polysaccharides in poly P-associated mutants, as well as increased secretion of autoinducer-2 (AI-2) quorum sensing molecules in the ∆ppk2 mutant. Further, the polysaccharide and flagellar biosynthesis genes, that are associated with biofilm formation, were altered in these poly P-associated mutants. We conclude that the phosphate limiting condition modulates C. jejuni biofilm formation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.4161/viru.34348

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[PMID]: 23962891
[Au] Autor:Bolbecker AR; Kent JS; Petersen IT; Klaunig MJ; Forsyth JK; Howell JM; Westfall DR; O'Donnell BF; Hetrick WP
[Ti] Title:Impaired cerebellar-dependent eyeblink conditioning in first-degree relatives of individuals with schizophrenia.
[So] Source:Schizophr Bull;40(5):1001-10, 2014 Sep.
[Is] ISSN:1745-1701
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Consistent with reports of cerebellar structural, functional, and neurochemical anomalies in schizophrenia, robust cerebellar-dependent delay eyeblink conditioning (dEBC) deficits have been observed in the disorder. Impaired dEBC is also present in schizotypal personality disorder, an intermediate phenotype of schizophrenia. The present work sought to determine whether dEBC deficits exist in nonpsychotic first-degree relatives of individuals with schizophrenia. A single-cue tone dEBC paradigm consisting of 10 blocks with 10 trials each (9 paired and 1 unpaired trials) was used to examine the functional integrity of cerebellar circuitry in schizophrenia participants, individuals with a first-degree relative diagnosed with schizophrenia, and healthy controls with no first-degree relatives diagnosed with schizophrenia. The conditioned stimulus (a 400ms tone) coterminated with the unconditioned stimulus (a 50ms air puff to the left eye) on paired trials. One relative and 2 healthy controls were removed from further analysis due to declining conditioned response rates, leaving 18 schizophrenia participants, 17 first-degree relatives, and 16 healthy controls. Electromyographic data were subsequently analyzed using growth curve models in hierarchical linear regression. Acquisition of dEBC conditioned responses was significantly impaired in schizophrenia and first-degree relative groups compared with controls. This finding that cerebellar-mediated associative learning deficits are present in first-degree relatives of individuals with schizophrenia provides evidence that dEBC abnormalities in schizophrenia may not be due to medication or course of illness effects. Instead, the present results are consistent with models of schizophrenia positing cerebellar-cortical circuit abnormalities and suggest that cerebellar abnormalities represent a risk marker for the disorder.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1093/schbul/sbt112

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[PMID]: 25056857
[Au] Autor:Alla SK; Sadhu P; Punniyamurthy T
[Ad] Address:Department of Chemistry, Indian Institute of Technology Guwahati , Guwahati 781039, Assam, India.
[Ti] Title:Organocatalytic Syntheses of Benzoxazoles and Benzothiazoles using Aryl Iodide and Oxone via C-H Functionalization and C-O/S Bond Formation.
[So] Source:J Org Chem;79(16):7502-11, 2014 Aug 15.
[Is] ISSN:1520-6904
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:An organocatalytic protocol for the syntheses of 2-substituted benzoxazoles and benzothiazoles is described from alkyl-/arylanilides and alkyl-/arylthioanilides using 1-iodo-4-nitrobenzene as catalyst and oxone as an inexpensive and environmentally safe terminal oxidant at room temperature in air via oxidative C-H functionalization and C-O/S bond formation. The procedure is simple and general and provides an effective route for the construction of functionalized 2-alkyl-/arylbenzoxazoles and 2-alkyl-/arylbenzothiazoles with moderate to high yields. The synthetic and mechanistic aspects have been described.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1021/jo501216h

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[PMID]: 24930869
[Au] Autor:Gherlone E; Mandelli F; Capparè P; Pantaleo G; Traini T; Ferrini F
[Ad] Address:Department of Dentistry, Vita Salute University, San Raffaele Hospital, Milan, Italy....
[Ti] Title:A 3 years retrospective study of survival for zirconia-based single crowns fabricated from intraoral digital impressions.
[So] Source:J Dent;42(9):1151-5, 2014 Sep.
[Is] ISSN:1879-176X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To evaluate the clinical performance of glass-ceramic/zirconia crowns fabricated using intraoral digital impressions - a retrospective study with a three-year follow-up. METHODS: 70 consecutive patients with a total of 86 glass-ceramic/zirconia crowns were treated by a single clinician using standardized clinical and laboratory protocols. A complete digital workflow was adopted for the purpose except for the veneering procedure for the glass-ceramic crowns. Occlusal adjustments were made before the ceramic glazing procedure. Before cementation, all abutments where carefully cleaned with a 70% alcoholic solution and air dried. Cementation was performed using dual-curing, self-adhesive resin cement. Patients were re-examined after 12, 24 and 36 months, to assess crown chipping/fractures. RESULTS: After the three-year follow-up, none of the zirconia-based restoration was lost ("apparent" survival rate 100%) otherwise, the chipping rate of the veneering material increased from 9.3% after 12 months, to 14% after 24 months to 30.2% after 36 months. As a consequence, the "real" success rate after 3 years was 69.8%. CONCLUSIONS: After 3 years the success rate of zirconia-based crowns was 69.8%, while the incidence of the chipping was 30.2%. Assuming an exponential increase in chipping rate between 12 and 36 months it can be argued that, among others, the fatigue-mechanism could be advocated as the main factor for the failure of glass-ceramic veneered zirconia especially after 24 months.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:D; IM
[St] Status:In-Data-Review

  6 / 259606 MEDLINE  
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[PMID]: 24613606
[Au] Autor:Keul C; Müller-Hahl M; Eichberger M; Liebermann A; Roos M; Edelhoff D; Stawarczyk B
[Ad] Address:Department of Prosthodontics, Munich Dental School, Munich, Germany....
[Ti] Title:Impact of different adhesives on work of adhesion between CAD/CAM polymers and resin composite cements.
[So] Source:J Dent;42(9):1105-14, 2014 Sep.
[Is] ISSN:1879-176X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To determine the impact of pre-treatment of adhesive systems on the work of adhesion (WA) between CAD/CAM polymers and resin composite cements and compare with conventional tests of previous studies. METHODS: Surface parameters were measured by contact angle measurement (2700 measurements) and WA was calculated. Five CAD/CAM polymers were used for fabrication of specimens (n=75/subgroup): artBloc Temp (A), Telio CAD (B), Nano Composite CFI-C (C), exp. CAD/CAM nanohybrid composite (D), and LAVA Ultimate (E). Then, air-abraded specimens were pre-treated (n=15 per group): Ambarino P60 (I), Monobond Plus/Heliobond (II), visio.link (III), VP connect (IV), and no pre-treatment (V). Resin composite cement specimens (n=75) were smoothed out homogeneously on a glass plate (n=15/group): RelyX ARC (RXA), Variolink II (VAR), Panavia F2.0 (PAN), RelyX Unicem (RXU), and Clearfil SA Cement (CSA). Contact angles were determined with 3 drops of distilled water and diiodomethane each. Data were analyzed using Kruskal-Wallis-H test and Spearman-Rho correlation (p<0.05). RESULTS: CAD/CAM materials (B), (A), and (C) showed higher WA compared to (D) and (E). (II) and (IV) resulted in higher WA than (I), (III) and (V). VAR had the significantly lowest WA, followed by RXU, RXA, CSA and PAN. No correlation occurred between WA and TBS/SBS whereas polar component of surface free energy of CAD/CAM resin and spreading coefficient showed significant positive correlation with TBS/SBS. CONCLUSIONS: Determination of WA is not a proper method to draw conclusions about the bond between resin materials. Destructive test methods are not dispensable. CLINICAL SIGNIFICANCE: The successful outcome of fixed dental restorations depends, among others, on the quality of bonding between the tooth and the restoration. Additional pre-treatment of the dental CAD/CAM resin restoration by bonding systems can be recommended for clinical use. Pre-treatment showed a significant impact on the surface properties.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:D; IM
[St] Status:In-Data-Review

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[PMID]: 24486739
[Au] Autor:Raanani P; Granot G; Ben-Bassat I
[Ad] Address:Institute of Hematology, Davidoff Center, Beilinson Hospital, Rabin Medical Center, Petah-Tikva, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: praanani@012.net.il.
[Ti] Title:Is cure of chronic myeloid leukemia in the third millennium a down to earth target (ed) or a castle in the air?
[So] Source:Cancer Lett;352(1):21-7, 2014 Sep 28.
[Is] ISSN:1872-7980
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:The therapeutic approach in chronic myeloid leukemia (CML) has undergone a revolutionary change during the last 2 decades with the introduction of the tyrosine kinase inhibitors. The use of these agents has changed overall survival as well as the quality of life of CML patients. Since the introduction of imatinib, newer agents have been developed and their role as first line treatment was examined. The use of genomics and proteomics as a means to tailor treatment of CML patients is underway. Meanwhile, clinical parameters as disease phase and response to treatment are used to guide a personalized approach. In this review, we will discuss the various aspects of personalized medicine in CML, including the use of the different scoring systems to guide treatment, disease phase as a means to choose the proper approach and the value of early response evaluation in decision-making. The approach towards patients resistant to tyrosine kinase inhibitors (TKIs), individual strategies for discontinuation of TKIs and "operational" cure in CML will also be discussed and finally the personalized treatment for CML patients in the near future based on present outcomes.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review

  8 / 259606 MEDLINE  
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[PMID]: 25063194
[Au] Autor:Jaspers RT; Testerink J; Della Gaspera B; Chanoine C; Bagowski CP; van der Laarse WJ
[Ad] Address:Laboratory for Myology, MOVE Research Institute Amsterdam, Faculty of Human Movement Sciences, VU University Amsterdam, 1081 BT Amsterdam, The Netherlands r.t.jaspers@vu.nl....
[Ti] Title:Increased oxidative metabolism and myoglobin expression in zebrafish muscle during chronic hypoxia.
[So] Source:Biol Open;3(8):718-27, 2014.
[Is] ISSN:2046-6390
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Fish may be extremely hypoxia resistant. We investigated how muscle fibre size and oxidative capacity in zebrafish (Danio rerio) adapt during severe chronic hypoxia. Zebrafish were kept for either 3 or 6 weeks under chronic constant hypoxia (CCH) (10% air/90%N2 saturated water). We analyzed cross-sectional area (CSA), succinate dehydrogenase (SDH) activity, capillarization, myonuclear density, myoglobin (Mb) concentration and Mb mRNA expression of high and low oxidative muscle fibres. After 3 weeks of CCH, CSA, SDH activity, Mb concentration, capillary and myonuclear density of both muscle fibre types were similar as under normoxia. In contrast, staining intensity for Mb mRNA of hypoxic high oxidative muscle fibres was 94% higher than that of normoxic controls (P<0.001). Between 3 and 6 weeks of CCH, CSA of high and low oxidative muscle fibres increased by 25 and 30%, respectively. This was similar to normoxic controls. Capillary and myonuclear density were not changed by CCH. However, in high oxidative muscle fibres of fish maintained under CCH, SDH activity, Mb concentration as well as Mb mRNA content were higher by 86%, 138% and 90%, respectively, than in muscle fibres of fish kept under normoxia (P<0.001). In low oxidative muscle fibres, SDH activity, Mb and Mb mRNA content were not significantly changed. Under normoxia, the calculated interstitial oxygen tension required to prevent anoxic cores in muscle fibres (PO2crit) of high oxidative muscle fibres was between 1.0 and 1.7 mmHg. These values were similar at 3 and 6 weeks CCH. We conclude that high oxidative skeletal muscle fibres of zebrafish continue to grow and increase oxidative capacity during CCH. Oxygen supply to mitochondria in these fibres may be facilitated by an increased Mb concentration, which is regulated by an increase in Mb mRNA content per myonucleus.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Da] Date of entry for processing:140816
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1242/bio.20149167

  9 / 259606 MEDLINE  
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[PMID]: 24997337
[Au] Autor:Tiwari KK; Chu C; Couroucli X; Moorthy B; Lingappan K
[Ad] Address:Department of Pediatrics, Section of Neonatology, Texas Children's Hospital, Baylor College of Medicine, 1102 Bates Avenue, MC: FC530.01, Houston, TX 77030, USA....
[Ti] Title:Differential concentration-specific effects of caffeine on cell viability, oxidative stress, and cell cycle in pulmonary oxygen toxicity in vitro.
[So] Source:Biochem Biophys Res Commun;450(4):1345-50, 2014 Aug 8.
[Is] ISSN:1090-2104
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Caffeine is used to prevent bronchopulmonary dysplasia (BPD) in premature neonates. Hyperoxia contributes to the development of BPD, inhibits cell proliferation and decreases cell survival. The mechanisms responsible for the protective effect of caffeine in pulmonary oxygen toxicity remain largely unknown. A549 and MLE 12 pulmonary epithelial cells were exposed to hyperoxia or maintained in room air, in the presence of different concentrations (0, 0.05, 0.1 and 1mM) of caffeine. Caffeine had a differential concentration-specific effect on cell cycle progression, oxidative stress and viability, with 1mM concentration being deleterious and 0.05mM being protective. Reactive oxygen species (ROS) generation during hyperoxia was modulated by caffeine in a similar concentration-specific manner. Caffeine at 1mM, but not at the 0.05mM concentration decreased the G2 arrest in these cells. Taken together this study shows the novel funding that caffeine has a concentration-specific effect on cell cycle regulation, ROS generation, and cell survival in hyperoxic conditions.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review

  10 / 259606 MEDLINE  
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[PMID]: 24951774
[Au] Autor:Wang H; Jafri A; Martin RJ; Nnanabu J; Farver C; Prakash YS; MacFarlane PM
[Ad] Address:Division of Neonatology, Rainbow Babies & Children's Hospital and Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio;...
[Ti] Title:Severity of neonatal hyperoxia determines structural and functional changes in developing mouse airway.
[So] Source:Am J Physiol Lung Cell Mol Physiol;307(4):L295-301, 2014 Aug 15.
[Is] ISSN:1522-1504
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Wheezing is a major long-term respiratory morbidity in preterm infants with and without bronchopulmonary dysplasia. We hypothesized that mild vs. severe hyperoxic exposure in neonatal mice differentially affects airway smooth muscle hypertrophy and resultant airway reactivity. Newborn mice were exposed to 7 days of mild (40% oxygen) or severe (70% oxygen) hyperoxia vs. room air controls. Respiratory system resistance (Rrs), compliance (Crs), and airway reactivity were measured 14 days after oxygen exposure ended under ketamine/xylazine anesthesia. Baseline Rrs increased and Crs decreased in both treatment groups. Methacholine challenge dose dependently increased Rrs and decreased Crs in 40% oxygen-exposed mice, whereas Rrs and Crs responses were similar between 70% oxygen-exposed and normoxic controls. Airway smooth muscle thickness was increased in 40%- but not 70%-exposed mice, whereas collagen increased and both alveolar number and radial alveolar counts decreased after 40% and 70% oxygen. These data indicate that severity of hyperoxia may differentially affect structural and functional changes in the developing mouse airway that contribute to longer-term hyperreactivity. These findings may be important to our understanding of the complex role of neonatal supplemental oxygen therapy in postnatal development of airway responsiveness.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1152/ajplung.00208.2013


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