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[PMID]: 29397088
[Au] Autor:Mahboubi M
[Ad] Address:Department of Microbiology, Medicinal Plants Research Center of Barij, Kashan, P.O. 1187, Iran. Electronic address: M_mahboubi@barijessence.com.
[Ti] Title:Management of acute cough by Zataria multiflora Boiss as an alternative treatment.
[So] Source:J Integr Med;16(1):20-25, 2018 Jan.
[Is] ISSN:2095-4964
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Cough, as a defensive reflux mechanism, removes foreign objects and secretions from bronchi and bronchioles of airways. Zataria multiflora is a popular plant for treatment of cough in Iranian traditional medicine. The aim of this review was to evaluate the potency of Z. multiflora as an alternative treatment in management of acute cough and its possible mechanisms of action. Here the authors compiled information about Z. multiflora in the treatment of cough from all accessible resources and books. The results of this investigation showed that there were five clinical studies that evaluated the efficacy of Z. multiflora essential oil or extract alone (n = 1), in combination with Althaea officinalis (n = 2) or Foeniculum vulgare essential oil (n = 1), in the form of syrup (n = 3), oral drop (n = 1) and soft capsule (n = 1), for the treatment of acute cough in comparison with placebo or synthetic drugs (bromhexine, dextromethorphan and clobutinol). All clinical studies confirmed the efficacy of Z. multiflora in the amelioration of acute cough in pediatric (n = 1) and adult patients (n = 4) without any adverse effects. Different mechanisms, such as anti-inflammatory, analgesic, antimicrobial, relaxant and immune-enhancement, may be responsible for the efficacy of Z. multiflora in cough relief. Other clinical trials can be performed with Z. multiflora in combination with ivy leaf extract or primrose root extract on patients with cough.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1802
[Cu] Class update date: 180204
[Lr] Last revision date:180204
[St] Status:In-Data-Review

  2 / 87 MEDLINE  
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[PMID]: 29169369
[Au] Autor:Arshad N; Mehreen A; Liaqat I; Arshad M; Afrasiab H
[Ad] Address:Department of Zoology, University of the Punjab, Lahore, Punjab, Pakistan. najmaarshad@gmail.com.
[Ti] Title:In vivo screening and evaluation of four herbs against MRSA infections.
[So] Source:BMC Complement Altern Med;17(1):498, 2017 Nov 23.
[Is] ISSN:1472-6882
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Recently, we reported high in vitro antibacterial efficacy of Althaea officinalis, Ziziphus jujuba, Cordia latifolia and Thymus vulgaris out of a total 21 plants against wide range of bacteria including MRSA. This study was therefore, designed to confirm efficacy of these four herbs against MRSA in an animal model. METHODS: A pilot study was conducted to establish the dose of S. aureus (KY698020) required to induce clinical infection. Afterword, in main trial, efficacy of aforementioned plant extracts on the course of sore throat was checked by evaluating general health, gross lesion score, bacterial load and hematology in mice. RESULTS: Pilot study revealed that 40l dose of 10 CFU/ml could induce infection which persist upto 08days post infection. Mice treated with T. vulgaris and Z. jujuba showed reduction in gross lesion score of both heart and lungs. Treatment with only some plants could significantly decrease bacterial load of throat (T. vulgaris) heart, blood and joint (C. latifolia, and T. vulagris). Hematological indicators confirmed in vivo control of MRSA infection in all treatment groups except A. officinalis. CONCLUSION: This is first report confirming in vivo anti-MRSA potential of C. latifolia and T. vulgaris and highlight the need to explore bioactive constituents of these plants. Moreover, previously reported in vitro antibacterial efficiency of A. officinalis could not be validated in current study.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171124
[Lr] Last revision date:171124
[St] Status:In-Process
[do] DOI:10.1186/s12906-017-2001-z

  3 / 87 MEDLINE  
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[PMID]: 28852633
[Au] Autor:Haghgoo R; Mehran M; Afshari E; Zadeh HF; Ahmadvand M
[Ad] Address:Department of Pediatric Dentistry, School of Dentistry, Shahed University, Tehran, Iran.
[Ti] Title:Antibacterial Effects of Different Concentrations of Root Extract versus 0.2% Chlorhexidine and Penicillin on and ( ).
[So] Source:J Int Soc Prev Community Dent;7(4):180-185, 2017 Jul-Aug.
[Is] ISSN:2231-0762
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:AIMS AND OBJECTIVES: The aims of the present study were to determine and compare the effects of different concentrations of extract, 0.2% chlorhexidine (CHX), and penicillin on and . MATERIALS AND METHODS: The laboratory study was done, for a period of 8 weeks. Minimum inhibitory concentration (MIC) in the test tube, minimum bactericidal concentration (MBC) in a plate culture medium, and growth inhibition zone diameter methods were used to compare the antibacterial effects of 0.2% CHX, penicillin, and different concentrations of root extract. The data were analyzed by SPSS version 24 using ANOVA and -test analysis. RESULTS: The results showed root extract had antibacterial effect, but significant differences were in MIC and MBC against and with penicillin and 0.2% CHX mouthwash. In addition, the mean growth inhibition zones of all the concentrations of the plant extract were less than that of the positive control group ( = 0.001). However, the difference in the maximum growth inhibition zone from that with the negative control group was significant. In addition, the antibacterial effect of the extract increased with an increase in its concentration. The extract exerted a greater antibacterial effect on than on . The plant polyphenols content is 3.7% which is equivalent to 29.93 g/ml. CONCLUSION: The root extract of exhibited antibacterial effects on and , but this effect was less than those of CHX mouthwash and penicillin. The antibacterial effect increased with an increase in the concentration of the extract.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170902
[Lr] Last revision date:170902
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.4103/jispcd.JISPCD_150_17

  4 / 87 MEDLINE  
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[PMID]: 28768940
[Au] Autor:Inomata A; Ogata A; Tada Y; Nagasawa A; Yuzawa K; Ando H; Kubo Y; Takahashi H; Kaihoko F; Tanaka K; Nakajima J; Suzuki A; Uemura N; Moriyasu T; Watanabe D; Ishihara K; Usami T; Kamei S; Kohno Y
[Ad] Address:Tokyo Metropolitan Institute of Public Health.
[Ti] Title:Inhalation Exposure Method for Illegal Drugs.
[So] Source:Yakugaku Zasshi;137(8):1005-1015, 2017.
[Is] ISSN:1347-5231
[Cp] Country of publication:Japan
[La] Language:jpn
[Ab] Abstract:We developed a new inhalation exposure method to evaluate effects of synthetic cannabimimetics that are being distributed as new, unregulated drugs in the Tokyo area. We selected the commercial product "SOUTOU" containing AB-CHMINACA and 5F-AMB as the test drug and dried marshmallow (Althaea officinalis) leaves as the negative control. A half cigarette packed with dried marshmallow leaves or SOUTOU was ignited, then mainstream smoke from each was delivered to five mice in an exposure box. After the cigarettes were fully consumed, neurobehavioral observations and a catalepsy test were performed at 15, 30 and 60 min after exposure. The effluent air from the exposure box was poured into impingers containing acetonitrile (first impinger) and dimethyl sulfoxide (second impinger). The resulting solutions were analyzed to assess decomposition of the synthetic cannabimimetics. Mice exposed to SOUTOU smoke showed many excitement behaviors and some suppressive behaviors at 15, 30 and 60 min. These clearly included cannabimimetic specific pharmacological actions. Negative control mice also showed some suppressive behaviors at 15 min but these were attenuated at later times, nearly disappearing at 60 min. In addition, the behavioral effects observed in controls were less pronounced than those in SOUTOU exposed mice. The inhalation exposure method developed in our study would be effective for determining cannabinoid specific pharmacological effects of illegal drugs, as well as for assessing the presence of active compound(s) by comparing the test substance with a negative control.
[Mh] MeSH terms primary: Atmosphere Exposure Chambers
Behavior, Animal/drug effects
Cannabinoids/adverse effects
Inhalation Exposure/adverse effects
Street Drugs/adverse effects
[Mh] MeSH terms secundary: Akathisia, Drug-Induced
Althaea
Animals
Cannabinoids/chemistry
Male
Mice, Inbred ICR
Plant Leaves
Time Factors
Tobacco Products
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Cannabinoids); 0 (Street Drugs)
[Em] Entry month:1710
[Cu] Class update date: 171030
[Lr] Last revision date:171030
[Js] Journal subset:IM
[Da] Date of entry for processing:170804
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.17-00019

  5 / 87 MEDLINE  
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[PMID]: 28612694
[Au] Autor:Oerlemans C; de Vries I; van Riel AJHP
[Ad] Address:Universitair Medisch Centrum Utrecht, Nationaal Vergiftigingen Informatie Centrum, Utrecht.
[Ti] Title:Anticholinerg syndroom door verontreinigde kruidenthee. [Anticholinergic syndrome caused by contaminated herbal tea; acting swiftly to identify the source].
[So] Source:Ned Tijdschr Geneeskd;161(0):D1261, 2017.
[Is] ISSN:1876-8784
[Cp] Country of publication:Netherlands
[La] Language:dut
[Ab] Abstract:BACKGROUND: Despite good manufacturing practice and quality control, consumer products can become contaminated. In some cases, this can result in severe and life-threatening intoxication with potentially fatal consequences. CASE DESCRIPTION: A 27-year-old man and a 28-year-old pregnant woman presented to the Emergency Department with severe anticholinergic syndrome after using a marshmallow root (Althaea officinalis) herbal remedy, mixed into hot chocolate drink, to reduce symptoms of common cold. After a short stay in Intensive Care, the symptoms diminished and the patients could be released from hospital. The herbs were found to be contaminated with atropine, most probably derived from deadly nightshade (Atropa belladonna). Analyses of the contaminated product indicated that the patients were exposed to 20-200 mg atropine, while a dose of 2 mg is already considered mildly toxic. CONCLUSION: Consultation of the Dutch National Poisons Information Center resulted in rapid detection of the contamination; close collaboration with the Netherlands Food and Consumer Product Safety Authority and the manufacturer of the product allowed rapid identification of the source of contamination and facilitated the prevention of an epidemic.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1706
[Cu] Class update date: 170614
[Lr] Last revision date:170614
[St] Status:In-Process

  6 / 87 MEDLINE  
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[PMID]: 28441343
[Au] Autor:Kim YS; Kim EK; Nawarathna WPAS; Dong X; Shin WB; Park JS; Moon SH; Park PJ
[Ad] Address:Department of Biotechnology, Konkuk University, Chungju, Chungbuk 27478, Korea. kimyonsuk@kku.ac.kr.
[Ti] Title:Immune-Stimulatory Effects of Althaea rosea Flower Extracts through the MAPK Signaling Pathway in RAW264.7 Cells.
[So] Source:Molecules;22(5), 2017 Apr 25.
[Is] ISSN:1420-3049
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:(Linn.) is a medicinal plant from China and Korea that has been traditionally used to control inflammation, to stop bedwetting and as a mouthwash in cases of bleeding gums. Its flowers are employed medicinally for their emollient, demulcent and diuretic properties, which make them useful in chest complaints. Furthermore, a flower extract decoction is used to improve blood circulation, for the treatment of constipation, dysmenorrhoea, haemorrhages, etc. However, the possible mechanisms of the immune-stimulatory effect remains to be elucidated. Therefore, we investigated the role of flower (ARF) extracts in the immune-stimulatory effect of macrophages and the underlying mechanisms of action. ARF water extract (ARFW) could dose-dependently increase NO production and cytokines (IL-6 and TNF-α). We also found that ARFW significantly increased the expression of iNOS and COX-2 proteins in RAW264.7 cells. Consistent with these results, MAPK protein (JNK, ERK, p38) expression levels were induced after treatment with ARFW. Additionally, ARFW showed a marked increase in the phosphorylation level of IκBα and subsequent IκBα degradation allowing NF-κB nuclear translocation. These results suggest that the immune-stimulatory effect of flower extracts is mediated through the translocation of NF-κB p65 subunit into the nucleus from the cytoplasm and subsequent activation of pro-inflammatory cytokines (IL-6 and TNF-α) and other mediators (iNOS and COX-2), which occurs mainly through MAPK signalling pathway. Thus, we suggest that ARFW could be considered as a potential therapeutic agent useful in the development of immune-stimulatory compounds.
[Mh] MeSH terms primary: Adjuvants, Immunologic/pharmacology
Althaea/chemistry
MAP Kinase Signaling System/drug effects
Plant Extracts/pharmacology
[Mh] MeSH terms secundary: Animals
Cell Survival/drug effects
Cyclooxygenase 2/metabolism
Drug Evaluation, Preclinical
Flowers/chemistry
Lipopolysaccharides/pharmacology
Mice
Nitric Oxide Synthase Type II/metabolism
RAW 264.7 Cells
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Adjuvants, Immunologic); 0 (Lipopolysaccharides); 0 (Plant Extracts); EC 1.14.13.39 (Nitric Oxide Synthase Type II); EC 1.14.13.39 (Nos2 protein, mouse); EC 1.14.99.- (Ptgs2 protein, mouse); EC 1.14.99.1 (Cyclooxygenase 2)
[Em] Entry month:1708
[Cu] Class update date: 170808
[Lr] Last revision date:170808
[Js] Journal subset:IM
[Da] Date of entry for processing:170426
[St] Status:MEDLINE

  7 / 87 MEDLINE  
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[PMID]: 28128955
[Au] Autor:Sendker J; Bker I; Lengers I; Brandt S; Jose J; Stark T; Hofmann T; Fink C; Abdel-Aziz H; Hensel A
[Ti] Title:Phytochemical Characterization of Low Molecular Weight Constituents from Marshmallow Roots (Althaea officinalis) and Inhibiting Effects of the Aqueous Extract on Human Hyaluronidase-1.
[So] Source:J Nat Prod;80(2):290-297, 2017 Feb 24.
[Is] ISSN:1520-6025
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Extract RE was obtained from the roots of Althaea officinalis in a yield of 8.1%, related to the dried plant material, by extraction with MeOH-H O (1:1), followed by precipitation with EtOH to remove high molecular weight constituents. Phytochemical investigation of RE revealed the presence of N-phenylpropenoyl-l-amino acid amides 1-5, 8% glycine betaine 6, about 9% total amino acids with proline as the main compound, and about 61% mono- and oligomeric carbohydrates with sucrose as the main compound. Further fractionation revealed the presence of a hypolaetin diglycoside (12) and four hypolaetin glycosides (7-9 and 11) with O-sulfocarbohydrate moieties; additionally, 4'-O-methylisoscutellarein-8-O--d-(3″-O-sulfo)glucuronopyranoside (10) and the diglycosylated coumarin haploperoside D (13) were identified. The hypolaetin-O-sulfoglycosides 7-10 are new natural products. RE inhibited the enzymatic activity of surface-displayed human hyaluronidase-1 on Escherichia coli F470 cells with an IC of 7.7 mg/mL. RE downregulated mRNA expression of hyal-1 in HaCaT keratinocytes at 125 and 250 g/mL, respectively. These data contribute to a deeper phytochemical understanding of marshmallow root extracts and to the positive influence of extracts used for therapy of irritated and inflamed buccal tissue and cough.
[Mh] MeSH terms primary: Althaea/chemistry
Flavonoids/isolation & purification
Flavonoids/pharmacology
Hyaluronoglucosaminidase/antagonists & inhibitors
[Mh] MeSH terms secundary: Flavonoids/chemistry
Humans
Keratinocytes/drug effects
Molecular Structure
Molecular Weight
Nuclear Magnetic Resonance, Biomolecular
Plant Roots/chemistry
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Flavonoids); EC 3.2.1.35 (Hyaluronoglucosaminidase)
[Em] Entry month:1707
[Cu] Class update date: 170714
[Lr] Last revision date:170714
[Js] Journal subset:IM
[Da] Date of entry for processing:170128
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b00670

  8 / 87 MEDLINE  
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[PMID]: 28101788
[Au] Autor:Naz R; Anis M; Alatar AA
[Ad] Address:Plant Biotechnology Laboratory, Department of Botany, Aligarh Muslim University, Aligarh, 202 002, India.
[Ti] Title:Embling Production in Althaea officinalis L., Through Somatic Embryogenesis and Their Appraisal via Histological and Scanning Electron Microscopical Studies.
[So] Source:Appl Biochem Biotechnol;182(3):1182-1197, 2017 Jul.
[Is] ISSN:1559-0291
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:In vitro propagation of a medicinally important plant, Althaea officinalis, has been achieved through somatic embryogenesis. Somatic embryos (globular to torpedo-shaped embryos) were induced on Murashige and Skoog's (MS) medium augmented with various concentrations of 2,4-dichlorophenoxyacetic acid (2,4-D, 5.0, 10.0, 15.0, 20.0, and 25.0) alone or combined with N6-benzylaminopurine (BA, 0.1, 0.5, 1.0, 1.5, and 2.0M). These were directly formed from the cut ends and subsequently spread on the whole surface of internodal explants. For embryo maturation, torpedo embryos were transferred on a medium containing different levels of BA (0.1, 0.5, or 1.0M) and abscisic acid (ABA) (0.5, 1.0, or 1.5M) or α-naphthalene acetic acid (NAA) (0.1, 0.5 or 1.0M). Among the different concentrations tested, 0.5M BA along with 1.0M ABA was found most effective, on which a highest yield (58.0%) with an optimum number (35.0) of mature embryos (cotyledonary stage) was observed after 2weeks of transfer. Germination of cotyledonary embryos into plantlets with 68% were observed on MS medium. Histological and scanning electron microscopical (SEM) studies proved that the regenerated structures were somatic embryos and not shoot primordia. Plants grew vigorously when transferred to a greenhouse.
[Mh] MeSH terms primary: Culture Media/chemistry
Plant Cells
Plant Somatic Embryogenesis Techniques/methods
[Mh] MeSH terms secundary: Althaea/metabolism
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Culture Media)
[Em] Entry month:1706
[Cu] Class update date: 170626
[Lr] Last revision date:170626
[Js] Journal subset:IM
[Da] Date of entry for processing:170120
[St] Status:MEDLINE
[do] DOI:10.1007/s12010-016-2391-2

  9 / 87 MEDLINE  
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[PMID]: 28093971
[Au] Autor:Mei X; Yi C; Huang G
[Ad] Address:College of Chemistry, Chongqing Normal University, Chongqing, 401331, China.
[Ti] Title:Preparation Methods and Antioxidant Activities of Polysaccharides and Their Derivatives.
[So] Source:Mini Rev Med Chem;17(10):863-868, 2017.
[Is] ISSN:1875-5607
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:BACKGROUND: In recent years, the antioxidant effects of polysaccharides have become a hot spot in the field of polysaccharide research. METHOD: Herein, the action mechanisms of polysaccharide antioxidation and scavenging free radicals were analyzed. The research progresses on the preparation methods and antioxidant properties of polysaccharides and their derivatives were summarized. CONCLUSION: Investigating the antioxidant activities of polysaccharides and their derivatives can find useful polysaccharides and their derivatives, which have great potential as natural antioxidants used in functional foods or medicines.
[Mh] MeSH terms primary: Antioxidants/chemistry
Polysaccharides/chemistry
[Mh] MeSH terms secundary: Althaea/chemistry
Althaea/metabolism
Antioxidants/isolation & purification
Ficus/chemistry
Ficus/metabolism
Plant Extracts/chemistry
Polysaccharides/isolation & purification
Reactive Oxygen Species/metabolism
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Antioxidants); 0 (Plant Extracts); 0 (Polysaccharides); 0 (Reactive Oxygen Species)
[Em] Entry month:1709
[Cu] Class update date: 170908
[Lr] Last revision date:170908
[Js] Journal subset:IM
[Da] Date of entry for processing:170118
[St] Status:MEDLINE
[do] DOI:10.2174/1389557517666170116114657

  10 / 87 MEDLINE  
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[PMID]: 27739873
[Au] Autor:Khan WU; Yasin NA; Ahmad SR; Ali A; Ahmed S; Ahmad A
[Ad] Address:a College of Earth and Environmental Sciences, University of the Punjab , Lahore , Pakistan.
[Ti] Title:Role of Ni-tolerant Bacillus spp. and Althea rosea L. in the phytoremediation of Ni-contaminated soils.
[So] Source:Int J Phytoremediation;19(5):470-477, 2017 May 04.
[Is] ISSN:1549-7879
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:In our current study, four nickel-tolerant (Ni-tolerant) bacterial species viz, Bacillus thuringiensis 002, Bacillus fortis 162, Bacillus subtilis 174, and Bacillus farraginis 354, were screened using Ni-contaminated media. The screened microbes exhibited positive results for synthesis of indole acetic acid (IAA), siderophore production, and phosphate solubilization. The effects of these screened microbes on Ni mobility in the soil, root elongation, plant biomass, and Ni uptake in Althea rosea plants grown in Ni-contaminated soil (200mg Ni kg ) were evaluated. Significantly higher value for water-extractable Ni (38mg kg ) was observed in case of Ni-amended soils inoculated with B. subtilis 174. Similarly, B. thuringiensis 002, B. fortis 162, and B. subtilis 174 significantly enhanced growth and Ni uptake in A. rosea. The Ni uptake in the shoots and roots of B. subtilis 174-inoculated plants enhanced up to 1.7 and 1.6-fold, respectively, as compared to that in the un-inoculated control. Bacterial inoculation also significantly improved the root and shoot biomass of treated plants. The current study presents a novel approach for bacteria-assisted phytoremediation of Ni-contaminated areas.
[Mh] MeSH terms primary: Althaea/metabolism
Bacillus/metabolism
Nickel/metabolism
Soil Pollutants/metabolism
[Mh] MeSH terms secundary: Althaea/growth & development
Althaea/microbiology
Biodegradation, Environmental
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Soil Pollutants); 7OV03QG267 (Nickel)
[Em] Entry month:1704
[Cu] Class update date: 170406
[Lr] Last revision date:170406
[Js] Journal subset:IM
[Da] Date of entry for processing:161015
[St] Status:MEDLINE
[do] DOI:10.1080/15226514.2016.1244167


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