Database : MEDLINE
Search on : ancylostomiasis [Words]
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[PMID]: 22677133
[Au] Autor:Taweethavonsawat P; Chungpivat S; Watanapongchati S; Traub RJ; Schaper R
[Ad] Address:Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand. Piyanan.T@chula.ac.th
[Ti] Title:Efficacy of a spot on combination containing imidacloprid 10% and moxidectin 1% (Advocate(®)/Advantage(®) Multi, Bayer Animal Health) against Ancylostoma ceylanicum in cats.
[So] Source:Vet Parasitol;190(1-2):289-93, 2012 Nov 23.
[Is] ISSN:1873-2550
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Ancylostoma ceylanicum is a common zoonotic hookworm of dogs and cats, especially in the Asia-Pacific region. The objective of this study was to determine the efficacy of a spot on combination product containing imidacloprid 10% and moxidectin 1% (Advocate(®)/Advantage(®) Multi, Bayer Animal Health) against A. ceylanicum in experimentally infected cats. Sixteen kittens were each subcutaneously injected with 100 infective third-stage larvae of A. ceylanicum. Kittens were stratified by egg count and randomly allocated into control and treatment groups. The kittens in the treatment group were each treated with a spot on combination of 10% (w/v) imidacloprid and 1% (w/v) moxidectin, administered topically at recommended label dose rates. The kittens in the control group were not treated. Egg counts were performed daily until the end of the study period and compared for the treated and control groups. No eggs were detected in the treated group of kittens within 4 days of treatment and faecal samples from this group remained negative throughout the rest of the study, resulting in a treatment efficacy (egg reduction) of 100% (P<0.0001). The egg counts remained high (993 ± 666 epg) in the untreated control group for the rest of the study period. This study demonstrated that based on faecal egg count reduction, the spot on combination containing imidacloprid 10% (w/v) and moxidectin 1% (w/v) (Advocate(®)/Advantage(®) Multi, Bayer Animal Health) given at the recommended dose is highly effective against infection with A. ceylanicum in cats.
[Mh] MeSH terms primary: Ancylostoma/drug effects
Ancylostomiasis/veterinary
Antinematodal Agents/administration & dosage
Cat Diseases/drug therapy
Skin Diseases, Parasitic/veterinary
[Mh] MeSH terms secundary: Administration, Topical
Ancylostoma/genetics
Ancylostomiasis/drug therapy
Ancylostomiasis/parasitology
Animals
Cat Diseases/parasitology
Cats
Drug Combinations
Feces/parasitology
Female
Imidazoles/administration & dosage
Larva
Macrolides/administration & dosage
Nitro Compounds/administration & dosage
Parasite Egg Count/veterinary
Skin Diseases, Parasitic/drug therapy
Skin Diseases, Parasitic/parasitology
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Antinematodal Agents); 0 (Drug Combinations); 0 (Imidazoles); 0 (Macrolides); 0 (Nitro Compounds); 3BN7M937V8 (imidacloprid); 51570-36-6 (milbemycin)
[Em] Entry month:1409
[Js] Journal subset:IM
[Da] Date of entry for processing:121008
[St] Status:MEDLINE

  2 / 1057 MEDLINE  
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[PMID]: 25092620
[Au] Autor:Wisniewski M; Lapinski M; Zdziarska A; Dlugosz E; Baska P
[Ad] Address:Division of Parasitology and Parasitic Diseases, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Ciszewskiego 8, 02-786 Warsaw, Poland. Electronic address: marcin_wisniewski@sggw.pl....
[Ti] Title:Molecular cloning and analysis of Ancylostoma ceylanicum glutamate-cysteine ligase.
[So] Source:Mol Biochem Parasitol;196(1):12-20, 2014 Aug.
[Is] ISSN:1872-9428
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Glutamate-cysteine ligase (GCL) is a heterodimer enzyme composed of a catalytic subunit (GCLC) and a modifier subunit (GCLM). This enzyme catalyses the synthesis of γ-glutamylcysteine, a precursor of glutathione. cDNAs of the putative glutamate-cysteine ligase catalytic (Ace-GCLC) and modifier subunits (Ace-GCLM) of Ancylostoma ceylanicum were cloned using the RACE-PCR amplification method. The Ace-gclc and Ace-gclm cDNAs encode proteins with 655 and 254 amino acids and calculated molecular masses of 74.76 and 28.51kDa, respectively. The Ace-GCLC amino acid sequence shares about 70% identity and 80% sequence similarity with orthologs in Loa loa, Onchocerca volvulus, Brugia malayi, and Ascaris suum, whereas the Ace-GCLM amino acid sequence has only about 30% sequence identity and 50% similarity to homologous proteins in those species. Real-time PCR analysis of mRNA expression in L3, serum stimulated L3 and adult stages of A. ceylanicum showed the highest level of Ace-GCLC and Ace-GCLM expression occurred in adult worms. No differences were detected among adult hookworms harvested 21 and 35dpi indicating expression of Ace-gclc and Ace-gclm in adult worms is constant during the course of infection. Positive interaction between two subunits of glutamate-cysteine ligase was detected using the yeast two-hybrid system, and by specific enzymatic reaction. Ace-GCL is an intracellular enzyme and is not exposed to the host immune system. Thus, as expected, we did not detect IgG antibodies against Ace-GCLC or Ace-GCLM on days 21, 60 and 120 of A. ceylanicum infection in hamsters. Furthermore, vaccination with one or both antigens did not reduce worm burdens, and resulted in no improvement of clinical parameters (hematocrit and hemoglobin) of infected hamsters. Therefore, due to the significant role of the enzyme in parasite metabolism, our analyses raises hope for the development of a successful new drug against ancylostomiasis based on the specific GCL inhibitor.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review

  3 / 1057 MEDLINE  
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[PMID]: 24891471
[Au] Autor:Ngui R; Lim YA; Ismail WH; Lim KN; Mahmud R
[Ad] Address:Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Parasite Southeast Asia Diagnostic (Para:SEAD) Laboratory, Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Sunway Medical Centre, No. 5, Jalan Lagoon Selatan,...
[Ti] Title:Zoonotic Ancylostoma ceylanicum infection detected by endoscopy.
[So] Source:Am J Trop Med Hyg;91(1):86-8, 2014 Jul.
[Is] ISSN:1476-1645
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:We report a case of Ancylostoma ceylanicum infection detected by endoscopy. It was diagnosed and confirmed using polymerase chain reaction (PCR) and DNA sequencing. The patient is a 58-year-old Malaysian woman who lives in a rural area, where uncontrolled populations of stray and semidomesticated dogs live in close proximity with humans.
[Mh] MeSH terms primary: Ancylostoma/isolation & purification
Ancylostomiasis/diagnosis
[Mh] MeSH terms secundary: Ancylostomiasis/pathology
Animals
Dogs
Endoscopy, Gastrointestinal
Female
Humans
Middle Aged
Zoonoses
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1409
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:140703
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.13-0756

  4 / 1057 MEDLINE  
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[PMID]: 24879000
[Au] Autor:Casmo V; Augusto G; Nala R; Sabonete A; Carvalho-Costa FA
[Ad] Address:Laboratório de Parasitologia Intestinal e Vesical do Instituto Nacional de Saúde de Moçambique, Cidade de Maputo, Moçambique....
[Ti] Title:The effect of hookworm infection and urinary schistosomiasis on blood hemoglobin concentration of schoolchildren living in northern Mozambique.
[So] Source:Rev Inst Med Trop Sao Paulo;56(3):219-24, 2014 May-Jun.
[Is] ISSN:1678-9946
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:This study aims to assess the association between schistosomiasis and hookworm infection with hemoglobin levels of schoolchildren in northern Mozambique. Through a cross-sectional survey, 1,015 children from five to 12 years old in the provinces of Nampula, Cabo Delgado and Niassa were studied. Hookworm infection and urinary schistosomiasis were diagnosed, through Ritchie and filtration methods, with a prevalence of 31.3% and 59.1%, respectively. Hemoglobin levels were obtained with a portable photometer (Hemocue®). The average hemoglobin concentration was 10.8 ± 1.42 g/dL, and 62.1% of the children presented levels below 11.5 g/dL, of which 11.8% of the total number of children had hemoglobin levels below 9 g/dL. A multiple linear regression analysis demonstrated negative interactions between hemoglobin levels and ancylostomiasis, this being restricted to the province of Cabo Delgado (ß = -0.55; p < 0.001) where an independent interaction between hemoglobin levels and urinary schistosomiasis was also observed (ß = -0.35; p = 0.016). The logistical regression model indicated that hookworm infection represents a predictor of mild (OR = 1.87; 95% CI = 1.17-3.00) and moderate/severe anemia (OR = 2.71; 95% CI = 1.50 - 4.89). We concluded that, in the province of Cabo Delgado, hookworm and Schistosoma haematobium infections negatively influence hemoglobin levels in schoolchildren. Periodical deworming should be considered in the region. Health education and improvements in sanitary infrastructure could achieve long-term and sustainable reductions in soil-transmitted helminthiases and schistosomiasis prevalence rates.
[Mh] MeSH terms primary: Anemia/parasitology
Hemoglobin A/analysis
Hookworm Infections/complications
Schistosomiasis haematobia/complications
[Mh] MeSH terms secundary: Anemia/blood
Animals
Child
Child, Preschool
Female
Hookworm Infections/blood
Humans
Male
Mozambique
Schistosomiasis haematobia/blood
Severity of Illness Index
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:9034-51-9 (Hemoglobin A)
[Em] Entry month:1408
[Js] Journal subset:IM
[Da] Date of entry for processing:140602
[St] Status:MEDLINE

  5 / 1057 MEDLINE  
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[PMID]: 23891152
[Au] Autor:Nguyen JB; Pool CD; Wong CY; Treger RS; Williams DL; Cappello M; Lea WA; Simeonov A; Vermeire JJ; Modis Y
[Ad] Address:Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
[Ti] Title:Peroxiredoxin-1 from the human hookworm Ancylostoma ceylanicum forms a stable oxidized decamer and is covalently inhibited by conoidin A.
[So] Source:Chem Biol;20(8):991-1001, 2013 Aug 22.
[Is] ISSN:1879-1301
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Hookworms are parasitic nematodes that have a devastating impact on global health, particularly in developing countries. We report a biochemical and structural analysis of a peroxiredoxin from the hookworm Ancylostoma ceylanicum, AcePrx-1. Peroxiredoxins provide antioxidant protection and act as signaling molecules and chaperones. AcePrx-1 is expressed in adult hookworms and can be inactivated by 2,3-bis(bromomethyl)quinoxaline-1,4-dioxide (conoidin A). Conoidin A inactivates AcePrx-1 by alkylating or crosslinking the catalytic cysteines, while maintaining the enzyme in the "locally unfolded" conformation. Irreversible oxidation of the resolving cysteine may contribute additional inhibitory activity. A crystal structure of oxidized AcePrx-1 reveals a disulfide-linked decamer. A helix macrodipole near the active site increases the reactivity of the catalytic cysteines to conoidin A. This work demonstrates the promise of conoidin compounds as probes to evaluate peroxiredoxins as drug targets in human parasites.
[Mh] MeSH terms primary: Ancylostoma/enzymology
Ancylostomiasis/parasitology
Peroxiredoxins/antagonists & inhibitors
Peroxiredoxins/chemistry
Quinoxalines/pharmacology
[Mh] MeSH terms secundary: Amino Acid Sequence
Ancylostoma/chemistry
Animals
Catalytic Domain/drug effects
Crystallography, X-Ray
Humans
Models, Molecular
Molecular Sequence Data
Oxidation-Reduction/drug effects
Peroxiredoxins/metabolism
Protein Conformation
Protein Multimerization/drug effects
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Name of substance:0 (Quinoxalines); 0 (conoidin A); EC 1.11.1.15 (Peroxiredoxins)
[Em] Entry month:1402
[Cu] Class update date: 140825
[Lr] Last revision date:140825
[Js] Journal subset:IM
[Da] Date of entry for processing:130826
[St] Status:MEDLINE

  6 / 1057 MEDLINE  
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[PMID]: 24516284
[Au] Autor:Phosuk I; Intapan PM; Thanchomnang T; Sanpool O; Janwan P; Laummaunwai P; Aamnart W; Morakote N; Maleewong W
[Ad] Address:Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. ; Research and Diagnostic Center for Emerging Infectious Diseases, Khon Kaen University, Khon Kaen 40002, Thailand....
[Ti] Title:Molecular detection of Ancylostoma duodenale, Ancylostoma ceylanicum, and Necator americanus in humans in northeastern and southern Thailand.
[So] Source:Korean J Parasitol;51(6):747-9, 2013 Dec.
[Is] ISSN:1738-0006
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:The 2 principal species of hookworms infecting humans are Necator americanus and Ancylostoma duodenale. Case studies on zoonotic hookworm infections with Ancylostoma ceylanicum and/or Ancylostoma caninum are known mainly from Asian countries. Of these 2 zoonotic species, only A. ceylanicum can develop to adulthood in humans. In the present study, we report a molecular-based survey of human hookworm infections present in southern and northeastern Thailand. Thirty larval hookworm samples were obtained from fecal agar plate cultures of 10 patients in northeastren Thailand and 20 in southern Thailand. Partial ITS1, 5.8S, and ITS2 regions of the ribosomal DNA genes were amplified using PCR. The amplicons were sequenced, aligned, and compared with other hookworm sequences in GenBank database. The results showed that, in Thailand, N. americanus is more prevalent than Ancylostoma spp. and is found in both study areas. Sporadic cases of A. ceylanicum and A. duodenale infection were seen in northeastern Thailand.
[Mh] MeSH terms primary: Ancylostoma/isolation & purification
Ancylostomiasis/epidemiology
Necator americanus/isolation & purification
Necatoriasis/epidemiology
[Mh] MeSH terms secundary: Ancylostoma/classification
Ancylostoma/genetics
Animals
Cluster Analysis
DNA, Ribosomal Spacer/chemistry
DNA, Ribosomal Spacer/genetics
Feces/parasitology
Humans
Molecular Sequence Data
Necator americanus/classification
Necator americanus/genetics
Phylogeny
Polymerase Chain Reaction
Prevalence
RNA, Ribosomal, 5.8S/genetics
Sequence Analysis, DNA
Sequence Homology, Nucleic Acid
Thailand/epidemiology
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (DNA, Ribosomal Spacer); 0 (RNA, Ribosomal, 5.8S)
[Em] Entry month:1408
[Js] Journal subset:IM
[Da] Date of entry for processing:140211
[St] Status:MEDLINE
[do] DOI:10.3347/kjp.2013.51.6.747

  7 / 1057 MEDLINE  
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[PMID]: 24768317
[Au] Autor:d'Ovidio D; Pepe P; Ianniello D; Noviello E; Quinton JF; Cringoli G; Rinaldi L
[Ad] Address:Private Practitioner, Naples, Italy....
[Ti] Title:First survey of endoparasites in pet ferrets in Italy.
[So] Source:Vet Parasitol;203(1-2):227-30, 2014 Jun 16.
[Is] ISSN:1873-2550
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Endoparasites are infrequently reported in ferrets. A cross-sectional survey was conducted to determine the prevalence of intestinal parasites in pet ferrets in southern Italy. Fresh fecal samples were randomly collected from 50 ferrets housed in pet shops or privately owned. All fecal samples were processed using the FLOTAC pellet technique to identify and count helminthic eggs/larvae and protozoan cysts/oocysts. In addition, the samples were analyzed also by the Remel XpectGiardia/Cryptosporidium immunoassay. Intestinal parasites were detected in 15 out of 50 ferrets (30%). Eggs of ancylostomids were found in 28.0% (14/50) of the animals and oocysts of Sarcocystis were detected in one ferret (2.0%). None of the samples was positive for Cryptosporidium or Giardia. To the authors' knowledge, this is the first report of sarcosporidiosis in a pet ferret in Italy.
[Mh] MeSH terms primary: Ancylostomiasis/veterinary
Ferrets/parasitology
Intestinal Diseases, Parasitic/veterinary
Parasitic Diseases, Animal/epidemiology
Pets/parasitology
Sarcocystosis/veterinary
[Mh] MeSH terms secundary: Ancylostoma
Ancylostomiasis/diagnosis
Ancylostomiasis/epidemiology
Animals
Cross-Sectional Studies
Feces/parasitology
Intestinal Diseases, Parasitic/epidemiology
Intestinal Diseases, Parasitic/parasitology
Italy
Parasite Egg Count
Parasitic Diseases, Animal/diagnosis
Parasitic Diseases, Animal/parasitology
Prevalence
Sarcocystis
Sarcocystosis/diagnosis
Sarcocystosis/epidemiology
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1406
[Js] Journal subset:IM
[Da] Date of entry for processing:140512
[St] Status:MEDLINE

  8 / 1057 MEDLINE  
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[PMID]: 24175305
[Au] Autor:Liu Y; Zheng G; Alsarakibi M; Zhang X; Hu W; Lu P; Lin L; Tan L; Luo Q; Li G
[Ad] Address:College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
[Ti] Title:Molecular identification of Ancylostoma caninum isolated from cats in southern China based on complete ITS sequence.
[So] Source:Biomed Res Int;2013:868050, 2013.
[Is] ISSN:2314-6141
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Ancylostoma caninum is a blood-feeding parasitic intestinal nematode which infects dogs, cats, and other mammals throughout the world. A highly sensitive and species-specific PCR-RFLP technique was utilised to detect the prevalence of A. caninum in cats in Guangzhou, southern China. Of the 102 fecal samples examined, the prevalence of A. caninum in cats was 95.1% and 83.3% using PCR-RFLP and microscopy, respectively. Among them, the prevalence of single hookworm infection with A. caninum was 54.90%, while mixed infections with both A. caninum and A. ceylanicum were 40.20%. Comparative analysis of three complete ITS sequences obtained from cat-derived A. caninum showed the same length (738 bp) as that of dog-derived A. caninum. However, the sequence variation range was 98.6%-100%, where only one cat isolate (M63) showed 100% sequence similarity in comparison with two dog-derived A. caninum isolates (AM850106, EU159416) in the same studied area. The phylogenetic tree revealed A. caninum derived from both cats and dogs in single cluster. Results suggest that cats could be the main host of A. caninum in China, which may cause cross-infection between dogs and cats in the same area.
[Mh] MeSH terms primary: Ancylostoma/genetics
Ancylostoma/isolation & purification
Ancylostomiasis/veterinary
Cat Diseases/parasitology
RNA, Helminth/genetics
[Mh] MeSH terms secundary: Ancylostoma/classification
Ancylostomiasis/epidemiology
Ancylostomiasis/parasitology
Animals
Cat Diseases/epidemiology
Cats
China/epidemiology
Dogs
Feces/parasitology
Phylogeny
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Prevalence
RNA, Helminth/isolation & purification
Species Specificity
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (RNA, Helminth)
[Em] Entry month:1406
[Js] Journal subset:IM
[Da] Date of entry for processing:131031
[St] Status:MEDLINE
[do] DOI:10.1155/2013/868050

  9 / 1057 MEDLINE  
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[PMID]: 24703073
[Au] Autor:Prullage JB; Knaus M; Bowman DD; Chester ST; Visser M; Rehbein S; Rosentel J
[Ad] Address:Merial Ltd., Duluth, GA 30096, USA. Electronic address: joseph.prullage@merial.com....
[Ti] Title:Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel against induced infections of Ancylostoma spp. nematodes of cats.
[So] Source:Vet Parasitol;202(1-2):30-3, 2014 Apr 28.
[Is] ISSN:1873-2550
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Four studies were conducted to examine the efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin, and praziquantel (BROADLINE(®), Merial) against Ancylostoma tubaeforme and Ancylostoma braziliense hookworms of cats. In each study, purpose-bred cats were randomly assigned to treatment groups of 10 or 12 cats per group. In three studies the cats were inoculated with A. tubaeforme and in one study with A. braziliense. The inoculations were undertaken on a schedule which resulted in the hookworms reaching the fourth larval stage in two of the studies, or the adult stage in four of the studies, by the day of treatment. In each study there was also an untreated control and 1 or 2 groups treated with the novel combination. In the two studies where efficacy against the fourth larval stage of A. tubaeforme was tested, the efficacy recorded was 100%. In the three studies where efficacy against the adult stage of A. tubaeforme was tested, efficacy of 100% was also confirmed. In the study where efficacy against the adult stage of A. braziliense was tested efficacy was 99.5%.
[Mh] MeSH terms primary: Ancylostomiasis/veterinary
Antiparasitic Agents/administration & dosage
Cat Diseases/drug therapy
[Mh] MeSH terms secundary: Ancylostoma/physiology
Ancylostomiasis/drug therapy
Animals
Cats
Drug Combinations
Ivermectin/administration & dosage
Ivermectin/analogs & derivatives
Methoprene/administration & dosage
Praziquantel/administration & dosage
Pyrazoles/administration & dosage
Random Allocation
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Antiparasitic Agents); 0 (Drug Combinations); 0 (Pyrazoles); 160902-72-7 (4''-epiacetylamino-4''-deoxyavermectin B1); 6490C9U457 (Praziquantel); 70288-86-7 (Ivermectin); 8B830OJ2UX (Methoprene); QGH063955F (fipronil)
[Em] Entry month:1406
[Js] Journal subset:IM
[Da] Date of entry for processing:140407
[St] Status:MEDLINE

  10 / 1057 MEDLINE  
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[PMID]: 23968813
[Au] Autor:Traub RJ
[Ad] Address:School of Veterinary Science, The University of Queensland, Gatton, Queensland 4343, Australia. Electronic address: r.traub@uq.edu.au.
[Ti] Title:Ancylostoma ceylanicum, a re-emerging but neglected parasitic zoonosis.
[So] Source:Int J Parasitol;43(12-13):1009-15, 2013 Nov.
[Is] ISSN:1879-0135
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Although Ancylostoma ceylanicum is known to be an endemic and widely distributed hookworm of dogs and cats in Asia, its contribution to human morbidity as a potentially zoonotic hookworm remains largely unexplored. Since its discovery by Lane (1913) as a 'new parasite' of humans a century ago, the hookworm has been regarded as a 'rare' and 'abnormal' parasite and largely overlooked in surveys of human parasites. Recent molecular-based surveys in Asia, however, have demonstrated that A. ceylanicum is the second most common hookworm species infecting humans, comprising between 6% and 23% of total patent hookworm infections. In experimentally induced infections, A. ceylanicum mimics the clinical picture produced by the anthroponotic hookworms of 'ground itch' and moderate to severe abdominal pain in the acute phase. Natural infections with A. ceylanicum in humans have been reported in almost all geographical areas in which the hookworm is known to be endemic in dogs and cats, however for the majority of reports, no clinical data are available. Much like the anthroponotic hookworm species, patent A. ceylanicum adults can isolate within the jejunum to produce chronic infections that on occasion, may occur in high enough burdens to produce anaemia. In addition, the hookworm can act much like Ancylostoma caninum and be found lower in the gastrointestinal tract leading to abdominal distension and pain, diarrhoea and occult blood in the faeces accompanied by peripheral eosinophilia. Whether A. ceylanicum is capable of producing both classical hookworm disease and evoking morbidity through an uncontrolled allergic response in some individuals remains unascertained. Future investigations combining the use of molecular diagnostic tools with clinical and pathological data will shed further light on its role as a human pathogen. The control of this zoonosis necessitates an integrated and inter-sectorial "One Health" approach be adopted in communities where large numbers of dogs share a close relationship with humans.
[Mh] MeSH terms primary: Ancylostomiasis/epidemiology
Communicable Diseases, Emerging/parasitology
Zoonoses
[Mh] MeSH terms secundary: Ancylostoma
Animals
Asia/epidemiology
Communicable Diseases, Emerging/epidemiology
Humans
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1405
[Js] Journal subset:IM
[Da] Date of entry for processing:131002
[St] Status:MEDLINE


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