Database : MEDLINE
Search on : ancylostomiasis [Words]
References found : 1085 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 109 go to page                         

  1 / 1085 MEDLINE  
              next record last record
select
to print
Photocopy

[PMID]: 26930954
[Au] Autor:Lan QL; Liu Q
[Ti] Title:[Upper gastrointestinal bleeding induced by hookworm infection: one case report].
[So] Source:Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi;27(5):558-9, 2015 Oct.
[Is] ISSN:1005-6661
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:This paper reports a case of upper gastrointestinal bleeding induced by hookworm infection, which was misdiagnosed at the beginning, and analyzes the causes of misdiagnosis.
[Mh] MeSH terms primary: Ancylostomiasis/complications
Ancylostomiasis/diagnosis
Diagnostic Errors
Gastrointestinal Hemorrhage/etiology
[Mh] MeSH terms secundary: Adult
Ancylostoma/isolation & purification
Ancylostoma/physiology
Ancylostomiasis/parasitology
Animals
Female
Gastrointestinal Hemorrhage/therapy
Gastrointestinal Tract/blood supply
Gastrointestinal Tract/parasitology
Host-Parasite Interactions
Humans
[Pt] Publication type:CASE REPORTS; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1604
[Js] Journal subset:IM
[Da] Date of entry for processing:160302
[St] Status:MEDLINE

  2 / 1085 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
SciELO Brazil full text

[PMID]: 26625923
[Au] Autor:Silva FT; Dias MO; Pinto Ada C; Santos NP
[Ad] Address:Instituto de Química, Universidade Federal do Rio de Janeiro, , fabio.chemistry@gmail.com.
[Ti] Title:"Pós de doliarina e ferro": um dos remédios importantes da Farmácia Peckolt. ["Doliarina and iron powder": an important medicine at Peckolt Pharmacy].
[So] Source:Hist Cienc Saude Manguinhos;22(4):1427-39, 2015 Dec.
[Is] ISSN:1678-4758
[Cp] Country of publication:Brazil
[La] Language:por
[Ab] Abstract:The pharmacist Theodoro Peckolt was one of the most important figures in the history of the chemistry of natural Brazilian products. Like other nineteenth-century pharmacists in Brazil, he developed formulations and sold them at his pharmacy in Rio de Janeiro, and these enjoyed great prestige in the eyes both of the public and the medical community. The article discusses the relation between the illness originally called "opilação" (ancylostomiasis, or hookworm) and nineteenth-century treatment. It focuses especially on Peckolt Pharmacy's "Doliarina and iron powder," a formulation extracted from the Ficus gomelleira rubber plant. One of the article's goals is to use modern methods to analyze Ficus gomelleira and identify the chemical composition of the drug.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1512
[Js] Journal subset:QIS
[St] Status:In-Process

  3 / 1085 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 26795262
[Au] Autor:Wisniewski M; Jaros S; Baska P; Cappello M; Dlugosz E; Wedrychowicz H
[Ad] Address:Division of Parasitology and Parasitic Diseases, Department of Preclinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, 02-0787 Warsaw, Ciszewskiego 8, Poland. Electronic address: marcin_wisniewski@sggw.pl....
[Ti] Title:Hamsters vaccinated with Ace-mep-7 DNA vaccine produced protective immunity against Ancylostoma ceylanicum infection.
[So] Source:Exp Parasitol;163:1-7, 2016 Apr.
[Is] ISSN:1090-2449
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Hookworms are intestinal nematodes that infect up to 740 million people, mostly in tropical and subtropical regions. Adult worms suck blood from damaged vessels in the gut mucosa, digesting hemoglobin using aspartic-, cysteine- and metalloproteases. Targeting aspartic hemoglobinases using drugs or vaccines is therefore a promising approach to ancylostomiasis control. Based on homology to metalloproteases from other hookworm species, we cloned the Ancylostoma ceylanicum metalloprotease 7 cDNA (Ace-mep-7). The corresponding Ace-MEP-7 protein has a predicted molecular mass of 98.8 kDa. The homology to metallopeptidases from other hookworm species and its predicted transmembrane region support the hypothesis that Ace-MEP-7 may be involved in hemoglobin digestion in the hookworm gastrointestinal tract, especially that our analyses show expression of Ace-mep-7 in the adult stage of the parasite. Immunization of Syrian golden hamsters with Ace-mep-7 cDNA resulted in 50% (p < 0.01) intestinal worm burden reduction. Additionally 78% (p < 0.05) egg count reduction in both sexes was observed. These results suggest that immunization with Ace-mep-7 may contribute to reduction in egg count released into the environment during the A. ceylanicum infection.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1603
[Js] Journal subset:IM
[St] Status:In-Data-Review

  4 / 1085 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 25683006
[Au] Autor:Ropars N; Tisseau L; Darrieux L; Safa G
[Ad] Address:Service de dermatologie, centre hospitalier de Saint-Brieuc, 10, rue Marcel-Proust, 22000 Saint-Brieuc, France....
[Ti] Title:Larva migrans cutanée ankylostomienne acquise en Bretagne: une zone d'endémie méconnue ? [Hookworm-related cutaneous larva migrans acquired in Brittany: a little-known endemic area?].
[So] Source:Ann Dermatol Venereol;142(4):285-6, 2015 Apr.
[Is] ISSN:0151-9638
[Cp] Country of publication:France
[La] Language:fre
[Mh] MeSH terms primary: Ancylostomiasis/diagnosis
Endemic Diseases
Larva Migrans/diagnosis
[Mh] MeSH terms secundary: Aged
Ancylostomiasis/epidemiology
Biopsy
Diagnosis, Differential
Eosinophilia/etiology
France/epidemiology
Humans
Humidity
Impetigo/diagnosis
Larva Migrans/epidemiology
Male
Soil/parasitology
[Pt] Publication type:CASE REPORTS; LETTER
[Nm] Name of substance:0 (Soil)
[Em] Entry month:1602
[Js] Journal subset:IM
[Da] Date of entry for processing:150406
[St] Status:MEDLINE

  5 / 1085 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 26018444
[Au] Autor:Pearson MS; Jariwala AR; Abbenante G; Plieskatt J; Wilson D; Bottazzi ME; Hotez PJ; Keegan B; Bethony JM; Loukas A
[Ad] Address:a Centre for Biodiscovery and Molecular Development of Therapeutics; Australian Institute of Tropical Health and Medicine; James Cook University; Cairns , Queensland , Australia.
[Ti] Title:New tools for NTD vaccines: A case study of quality control assays for product development of the human hookworm vaccine Na-APR-1M74.
[So] Source:Hum Vaccin Immunother;11(5):1251-7, 2015.
[Is] ISSN:2164-554X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Na-APR-1(M74) is an aspartic protease that is rendered enzymatically inactive by site-directed mutagenesis and is a candidate antigen component in the Human Hookworm Vaccine. The mutant protease exerts vaccine efficacy by inducing antibodies that neutralize the enzymatic activity of wild type enzyme (Na-APR-1wt) in the gut of the hookworm, thereby depriving the worm of its ability to digest its blood meal. Previously, canines immunized with Na-APR-1(M74) and challenged with Ancylostoma caninum were partially protected against hookworm challenge infection, especially from the loss in hemoglobin observed in control canines and canine immunoglobulin (Ig) G raised against Na-APR-1 was shown to inhibit the enzymatic activity of Na-APR-1 wt in vitro, thereby providing proof of concept of Na-APR-1(M74) as a vaccine antigen. The mutated version, Na-APR-1(M74), was then expressed at the cGMP level using a Nicotiana benthamiana expression system (Fraunhofer, CMB, Delaware, MD), formulated with Alhydrogel®, and used to immunize mice in a dose-ranging study to explore the enzyme-neutralizing capacity of the resulting anti- Na-APR-1(M74) IgG. As little as 0.99 µg of recombinant Na-APR-1(M74) could induce anti Na-APR-1(M74) IgG in mice that were capable of inhibiting Na-APR-1w t-mediated digestion of a peptide substrate by 89%. In the absence of enzymatic activity of Na-APR-1(M74) as a surrogate marker of protein functionality, we developed an assay based on the binding of a quenched fluorescence-labeled inhibitor of aspartic proteases, BODIPY-FL pepstatin A (BDP). Binding of BDP in the active site of Na-APR-1 wt was demonstrated by inhibition of enzymatic activity, and competitive binding with unlabelled pepstatin A. BDP also bound to Na-APR-1(M74) which was assessed by fluorescence polarization, but with an ∼ 50-fold reduction in the dissociation constant. Taken together, these assays comprise a "toolbox" that could be useful for the analyses of Na-APR-1(M74) as it proceeds through the clinical development as part of the Human Hookworm Vaccine pipeline.
[Mh] MeSH terms primary: Ancylostoma/enzymology
Ancylostomiasis/prevention & control
Antigens, Helminth/immunology
Aspartic Acid Proteases/immunology
Hookworm Infections/prevention & control
Recombinant Proteins/immunology
[Mh] MeSH terms secundary: Adjuvants, Immunologic/administration & dosage
Aluminum Hydroxide/administration & dosage
Ancylostoma/immunology
Animals
Antibodies, Helminth/blood
Antibodies, Neutralizing/blood
Antigens, Helminth/genetics
Aspartic Acid Proteases/genetics
Drug Discovery/methods
Female
Mice, Inbred BALB C
Mutant Proteins/genetics
Mutant Proteins/immunology
Plants, Genetically Modified/genetics
Plants, Genetically Modified/metabolism
Quality Control
Recombinant Proteins/genetics
Tobacco/genetics
Tobacco/metabolism
Vaccines, Synthetic/administration & dosage
Vaccines, Synthetic/genetics
Vaccines, Synthetic/immunology
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Adjuvants, Immunologic); 0 (Antibodies, Helminth); 0 (Antibodies, Neutralizing); 0 (Antigens, Helminth); 0 (Mutant Proteins); 0 (Recombinant Proteins); 0 (Vaccines, Synthetic); 5QB0T2IUN0 (Aluminum Hydroxide); EC 3.4.- (Aspartic Acid Proteases)
[Em] Entry month:1602
[Cu] Class update date: 151223
[Lr] Last revision date:151223
[Js] Journal subset:IM
[Da] Date of entry for processing:150528
[St] Status:MEDLINE
[do] DOI:10.4161/21645515.2014.980199

  6 / 1085 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 25911163
[Au] Autor:Marcus AD; Higgins DP; Gray R
[Ad] Address:Faculty of Veterinary Science, The University of Sydney, McMaster Bldg B14, Sydney, New South Wales, 2006, Australia.
[Ti] Title:Ivermectin treatment of free-ranging endangered Australian sea lion (Neophoca cinerea) pups: effect on hookworm and lice infection status, haematological parameters, growth, and survival.
[So] Source:Parasitol Res;114(7):2743-55, 2015 Jul.
[Is] ISSN:1432-1955
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:A placebo-controlled study was used to investigate the effectiveness of ivermectin to treat hookworm (Uncinaria sanguinis) and lice (Antarctophthirus microchir) infections in free-ranging Australian sea lion (Neophoca cinerea) pups and to test the hypotheses that these parasitic infections cause anaemia, systemic inflammatory responses, and reduced growth, and contribute towards decreased pup survival. Ivermectin was identified as an effective and safe anthelmintic in this species. Pups administered ivermectin had significantly higher erythrocyte counts and significantly lower eosinophil counts compared to controls at 1-2 months post-treatment, confirming that U. sanguinis and/or A. microchir are causatively associated with disease and demonstrating the positive effect of ivermectin treatment on clinical health parameters. Higher growth rates were not seen in ivermectin-treated pups and, unexpectedly, relatively older pups treated with ivermectin demonstrated significantly reduced growth rates when compared to matched saline-control pups. Differences in survival were not identified between treatment groups; however, this was attributed to the unexpectedly low mortality rate of recruited pups, likely due to the unintended recruitment bias towards pups >1-2 months of age for which mortality due to hookworm infection is less likely. This finding highlights the logistical and practical challenges associated with treating pups of this species shortly after birth at a remote colony. This study informs the assessment of the use of anthelmintics as a tool for the conservation management of free-ranging wildlife and outlines essential steps to further the development of strategies to ensure the effective conservation of the Australian sea lion and its parasitic fauna.
[Mh] MeSH terms primary: Ancylostomatoidea/drug effects
Ancylostomiasis/veterinary
Anoplura/drug effects
Antiparasitic Agents/administration & dosage
Hookworm Infections/veterinary
Ivermectin/administration & dosage
Sea Lions/parasitology
[Mh] MeSH terms secundary: Ancylostomatoidea/physiology
Ancylostomiasis/blood
Ancylostomiasis/drug therapy
Ancylostomiasis/parasitology
Animals
Antiparasitic Agents/adverse effects
Australia
Endangered Species
Hookworm Infections/blood
Hookworm Infections/drug therapy
Hookworm Infections/parasitology
Ivermectin/adverse effects
Sea Lions/growth & development
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Antiparasitic Agents); 70288-86-7 (Ivermectin)
[Em] Entry month:1602
[Js] Journal subset:IM
[Da] Date of entry for processing:150624
[St] Status:MEDLINE
[do] DOI:10.1007/s00436-015-4481-4

  7 / 1085 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 26434973
[Au] Autor:Chirapongsathorn S; Kamath PS
[Ad] Address:Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN; Division of Gastroenterology, Department of Medicine, Phramongkutklao Hospital and College of Medicine, Royal Thai Army, Bangkok, Thailand.
[Ti] Title:Iron-Deficiency Anemia With an Itch.
[So] Source:Mayo Clin Proc;90(10):1458, 2015 Oct.
[Is] ISSN:1942-5546
[Cp] Country of publication:England
[La] Language:eng
[Mh] MeSH terms primary: Ancylostoma/isolation & purification
Ancylostomiasis
Anemia, Iron-Deficiency
Anthelmintics/therapeutic use
Iron Compounds/therapeutic use
Pruritus/etiology
[Mh] MeSH terms secundary: Adult
Ancylostomiasis/complications
Ancylostomiasis/diagnosis
Ancylostomiasis/parasitology
Ancylostomiasis/physiopathology
Ancylostomiasis/therapy
Anemia, Iron-Deficiency/diagnosis
Anemia, Iron-Deficiency/drug therapy
Anemia, Iron-Deficiency/etiology
Anemia, Iron-Deficiency/physiopathology
Animals
Female
Humans
Treatment Outcome
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Anthelmintics); 0 (Iron Compounds)
[Em] Entry month:1601
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:151005
[St] Status:MEDLINE

  8 / 1085 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
PubMed Central Full text
Full text

[PMID]: 25254370
[Au] Autor:Pacanaro CP; Dias SR; Serafim LR; Costa MP; Aguilar E; Paes PR; Alvarez-Leite JI; Rabelo EM
[Ad] Address:Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil....
[Ti] Title:Evaluation of biochemical, hematological and parasitological parameters of protein-deficient hamsters infected with Ancylostoma ceylanicum.
[So] Source:PLoS Negl Trop Dis;8(9):e3184, 2014 Sep.
[Is] ISSN:1935-2735
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Hookworms infect millions of people worldwide and can cause severe clinical symptoms in their hosts. Prospective cohort studies in Brazil show high rates of hookworm reinfection in malnourished children compared to well-nourished children, despite previous treatment. Additionally, soil-transmitted helminth (STH) infections can worsen the nutritional status of affected populations. Therefore, this study aims to clarify the effects of host malnutrition during Ancylostoma ceylanicum infection and how this infection affects host physiological parameters using a hamster model. METHODOLOGY/PRINCIPAL FINDINGS: Hamsters were divided into four experimental groups: normal diet or low-protein diet (also referred to as "malnourished") and A. ceylanicum infection or no infection. More severe pathogenesis was observed in the infected malnourished group, as demonstrated by significant decreases in the hemoglobin concentration, erythrocyte number and packed-cell volume compared to the non-infected malnourished group. Greater numbers of adult parasites and eggs were observed in the malnourished group compared to the control group; however, the oviposition rate was lower in the malnourished group. In general, greater values of total lipids were observed in malnourished animals compared to control animals, including lipids excreted in the stool. CONCLUSIONS: In this work, we have demonstrated that animals fed an isocaloric low-protein diet presented more severe pathogenesis when infected with A. ceylanicum. The increased lipid concentration in the liver and blood is related to the conversion of the excess carbohydrate into fatty acids that increase the concentration of triglycerides in general. Triglycerides were excreted in the feces, indicating that infection associated with malnutrition caused a greater loss of these molecules for this group of animals and confirming the hypothesis that both nutrition and infection are responsible for the malabsorption syndrome. Taken together, the results found in this work confirm the hypothesis that the nutritional condition of the host greatly influences the course of the infection.
[Mh] MeSH terms primary: Ancylostoma
Ancylostomiasis/metabolism
Ancylostomiasis/parasitology
Protein Deficiency/metabolism
Protein Deficiency/parasitology
[Mh] MeSH terms secundary: Ancylostomiasis/blood
Animals
Blood Proteins/metabolism
Cricetinae
Diet, Protein-Restricted
Disease Models, Animal
Female
Lipids/blood
Protein Deficiency/blood
Random Allocation
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Blood Proteins); 0 (Lipids)
[Em] Entry month:1601
[Js] Journal subset:IM
[Da] Date of entry for processing:140926
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0003184

  9 / 1085 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 25291046
[Au] Autor:Sayasone S; Utzinger J; Akkhavong K; Odermatt P
[Ad] Address:National Institute of Public Health, Ministry of Health, Vientiane, Lao People's Democratic Republic; Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, P.O. Box, CH-4002 Basel, Switzerland; University of Basel, P.O. Box, CH-4003 Basel, Switzerland....
[Ti] Title:Multiparasitism and intensity of helminth infections in relation to symptoms and nutritional status among children: a cross-sectional study in southern Lao People's Democratic Republic.
[So] Source:Acta Trop;141(Pt B):322-31, 2015 Jan.
[Is] ISSN:1873-6254
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:The occurrence and spatial distribution of intestinal helminth infection in children is fairly well understood. However, knowledge on how helminth infections govern intestinal morbidity is scarce. We conducted a cross-sectional study to assess and quantify the relationship between single and multiple species helminth infection with clinical and self-reported morbidity indicators and nutritional status in Champasack province, southern Lao People's Democratic Republic (Lao PDR). A random sample of 1313 children, aged 6 months to 12 years, from villages in nine rural districts were enrolled and examined for helminth infection using duplicate Kato-Katz thick smears. Morbidity was assessed by self-reported symptoms, coupled with clinical examination and appraisal of nutritional status and anaemia. Bivariate and multivariate logistic regression was employed to study associations between helminth infection and morbidity indicators and anaemia. We found considerable morbidity among the surveyed children, including hepatomegaly (13.7%), pale conjunctiva (13.2%) and abdominal pain (10.4%). Anaemia was recorded in 60.4% of the children, whilst signs of stunting and low body mass index (BMI) were observed in 49.8% and 33.3% of the surveyed children, respectively. Hookworm and Opisthorchis viverrini were the predominant helminth species with prevalences of 51.0% and 43.3%, respectively. The prevalence of Schistosoma mekongi in the surveyed children was 5.6%. Multiple species helminth infections were recorded in 40.4% of the study cohort. Morbidity was associated with specific helminth species infection (e.g. S. mekongi with hepatomegaly; adjusted odds ratio (aOR): 9.49, 95% confidence interval (CI): 2.07-43.51) and multiparasitism (e.g. two or more helminth species with abdominal pain; aOR: 2.40, 95% CI: 1.46-3.93). Anaemia was associated with hookworm infection (aOR: 1.64, 95% CI: 1.16-2.34) and multiparasitism (aOR: 1.64, 95% CI: 1.18-2.29). Low BMI was associated with O. viverrini infection (aOR: 1.68, 95% CI: 1.14-2.49) and multiparasitism (aOR: 1.42, 95% CI: 1.01-2.00). The multiple strong associations reported here between helminth infections (single or multiple species) and intestinal morbidity among children in rural parts of southern Lao PDR call for concerted efforts to control helminth infections, which in turn might improve children's health and development.
[Mh] MeSH terms primary: Anemia/epidemiology
Coinfection/epidemiology
Gastrointestinal Hemorrhage/epidemiology
Helminthiasis/epidemiology
Intestinal Diseases, Parasitic/epidemiology
Nutritional Status
Thinness/epidemiology
[Mh] MeSH terms secundary: Ancylostomatoidea
Ancylostomiasis/complications
Ancylostomiasis/epidemiology
Ancylostomiasis/physiopathology
Anemia/etiology
Animals
Child
Child, Preschool
Cross-Sectional Studies
Feces
Female
Gastrointestinal Hemorrhage/etiology
Helminthiasis/complications
Helminthiasis/physiopathology
Helminths
Hookworm Infections/complications
Hookworm Infections/epidemiology
Hookworm Infections/physiopathology
Humans
Infant
Intestinal Diseases, Parasitic/complications
Intestinal Diseases, Parasitic/physiopathology
Laos/epidemiology
Logistic Models
Male
Opisthorchiasis/complications
Opisthorchiasis/epidemiology
Opisthorchiasis/physiopathology
Opisthorchis
Prevalence
Rural Population/statistics & numerical data
Schistosomiasis/epidemiology
Schistosomiasis/physiopathology
Questionnaires
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1601
[Js] Journal subset:IM
[Da] Date of entry for processing:141216
[St] Status:MEDLINE

  10 / 1085 MEDLINE  
              first record previous record
select
to print
Photocopy
PubMed Central Full text
Full text

[PMID]: 26421808
[Au] Autor:Nikolay B; Mwandawiro CS; Kihara JH; Okoyo C; Cano J; Mwanje MT; Sultani H; Alusala D; Turner HC; Teti C; Garn J; Freeman MC; Allen E; Anderson RM; Pullan RL; Njenga SM; Brooker SJ
[Ad] Address:Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom....
[Ti] Title:Understanding Heterogeneity in the Impact of National Neglected Tropical Disease Control Programmes: Evidence from School-Based Deworming in Kenya.
[So] Source:PLoS Negl Trop Dis;9(9):e0004108, 2015 Sep.
[Is] ISSN:1935-2735
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: The implementation of soil-transmitted helminth (STH) treatment programmes occurs in varied environmental, social and economic contexts. Programme impact will be influenced by factors that affect the reduction in the prevalence and intensity of infections following treatment, as well as the subsequent rate of reinfection. To better understand the heterogeneity of programme impact and its underlying reasons, we investigated the influence of contextual factors on reduction in STH infection as part of the national school based deworming (SBD) programme in Kenya. MATERIALS AND METHODS: Data on the prevalence and intensity of infection were collected within the monitoring and evaluation component of the SBD programme at baseline and after delivery of two annual treatment rounds in 153 schools in western Kenya. Using a framework that considers STH epidemiology and transmission dynamics, capacity to deliver treatment, operational feasibility and financial capacity, data were assembled at both school and district (county) levels. Geographic heterogeneity of programme impact was assessed by descriptive and spatial analyses. Factors associated with absolute reductions of Ascaris lumbricoides and hookworm infection prevalence and intensity were identified using mixed effects linear regression modelling adjusting for baseline infection levels. PRINCIPAL FINDINGS: The reduction in prevalence and intensity of A. lumbricoides and hookworms varied significantly by county and within counties by school. Multivariable analysis of factors associated with programme impact showed that absolute A. lumbricoides reductions varied by environmental conditions and access to improved sanitation at schools or within the community. Larger reduction in prevalence and intensity of hookworms were found in schools located within areas with higher community level access to improved sanitation and within counties with higher economic and health service delivery indicator scores. CONCLUSIONS: The study identifies factors associated with the impact of school-based deworming and in particular highlights how access to water, sanitation and hygiene and environmental conditions influence the impact of deworming programmes.
[Mh] MeSH terms primary: Antinematodal Agents/administration & dosage
Neglected Diseases/therapy
Nematode Infections/epidemiology
Nematode Infections/therapy
Program Evaluation
School Health Services/statistics & numerical data
[Mh] MeSH terms secundary: Ancylostomiasis/epidemiology
Ancylostomiasis/therapy
Ancylostomiasis/transmission
Animals
Ascariasis/epidemiology
Ascariasis/therapy
Ascariasis/transmission
Delivery of Health Care
Humans
Kenya/epidemiology
Neglected Diseases/epidemiology
Prevalence
Public Health
Socioeconomic Factors
Trichuriasis/epidemiology
Trichuriasis/therapy
Water/parasitology
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Antinematodal Agents); 059QF0KO0R (Water)
[Em] Entry month:1601
[Cu] Class update date: 151003
[Lr] Last revision date:151003
[Js] Journal subset:IM
[Da] Date of entry for processing:151001
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0004108


page 1 of 109 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information