Database : MEDLINE
Search on : ancylostomiasis [Words]
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[PMID]: 25606735
[Au] Autor:Korndörfer AP
[Ad] Address:Universidade do Vale do Rio dos Sinos.
[Ti] Title:Para além do combate à ancilostomíase: o diário do médico norte-americano Alan Gregg. [Looking beyond the campaign to eradicate ancylostomiasis: the diary of the American physician Alan Gregg].
[So] Source:Hist Cienc Saude Manguinhos;21(4):1457-66, 2014 Dec.
[Is] ISSN:1678-4758
[Cp] Country of publication:Brazil
[La] Language:por
[Ab] Abstract:Between 1916 and 1923, the Federal District and 11 Brazilian states entered into cooperation agreements with the International Health Board of the Rockefeller Foundation to combat a rural endemic disease, namely ancylostomiasis. This paper presents the diary of Alan Gregg, one of the American physicians who worked in Brazil from 1919 to 1922. An interesting source to discuss issues relating to the history of public health in Brazil, in addition to information about the activities to combat ancylostomiasis developed by the Rockefeller Foundation in the country, the diary of the physician presents his impressions concerning nature, culture, politics and society in Brazil. In the diary excerpts presented here, however, aspects related to the professional activities performed by Gregg are prioritized.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1501
[Js] Journal subset:QIS
[St] Status:In-Data-Review

  2 / 1062 MEDLINE  
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[PMID]: 24865815
[Au] Autor:Inpankaew T; Schär F; Dalsgaard A; Khieu V; Chimnoi W; Chhoun C; Sok D; Marti H; Muth S; Odermatt P; Traub RJ
[Ti] Title:High prevalence of Ancylostoma ceylanicum hookworm infections in humans, Cambodia, 2012.
[So] Source:Emerg Infect Dis;20(6):976-82, 2014 Jun.
[Is] ISSN:1080-6059
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Ancylostoma ceylanicum, a hookworm of canids and felids in Asia, is becoming the second most common hookworm infecting humans. In 2012, we investigated the prevalence and infection dynamics of and risk factors for hookworm infections in humans and dogs in a rural Cambodian village. Over 57% of the population was infected with hookworms; of those, 52% harbored A. ceylanicum hookworms. The greatest intensities of A. ceylanicum eggs were in persons 21-30 years of age. Over 90% of dogs also harbored A. ceylanicum hookworms. Characterization of the cytochrome oxidase-1 gene divided isolates of A. ceylanicum hookworms into 2 groups, 1 containing isolates from humans only and the other a mix of isolates from humans and animals. We hypothesize that preventative chemotherapy in the absence of concurrent hygiene and animal health programs may be a factor leading to emergence of A. ceylanicum infections; thus, we advocate for a One Health approach to control this zoonosis.
[Mh] MeSH terms primary: Ancylostoma/genetics
Ancylostomiasis/veterinary
Dog Diseases/epidemiology
Electron Transport Complex IV/genetics
Helminth Proteins/genetics
[Mh] MeSH terms secundary: Adolescent
Adult
Ancylostoma/classification
Ancylostoma/isolation & purification
Ancylostomiasis/epidemiology
Ancylostomiasis/parasitology
Ancylostomiasis/transmission
Animals
Cambodia/epidemiology
Child
Child, Preschool
Dog Diseases/parasitology
Dog Diseases/transmission
Dogs
Feces/parasitology
Female
Humans
Male
Middle Aged
Phylogeny
Prevalence
Rural Population
Zoonoses
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Helminth Proteins); EC 1.9.3.1 (Electron Transport Complex IV)
[Em] Entry month:1501
[Js] Journal subset:IM
[Da] Date of entry for processing:140528
[St] Status:MEDLINE
[do] DOI:10.3201/eid2006.131770

  3 / 1062 MEDLINE  
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[PMID]: 25092620
[Au] Autor:Wisniewski M; Lapinski M; Zdziarska A; Dlugosz E; Baska P
[Ad] Address:Division of Parasitology and Parasitic Diseases, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Ciszewskiego 8, 02-786 Warsaw, Poland. Electronic address: marcin_wisniewski@sggw.pl....
[Ti] Title:Molecular cloning and analysis of Ancylostoma ceylanicum glutamate-cysteine ligase.
[So] Source:Mol Biochem Parasitol;196(1):12-20, 2014 Aug.
[Is] ISSN:1872-9428
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Glutamate-cysteine ligase (GCL) is a heterodimer enzyme composed of a catalytic subunit (GCLC) and a modifier subunit (GCLM). This enzyme catalyses the synthesis of γ-glutamylcysteine, a precursor of glutathione. cDNAs of the putative glutamate-cysteine ligase catalytic (Ace-GCLC) and modifier subunits (Ace-GCLM) of Ancylostoma ceylanicum were cloned using the RACE-PCR amplification method. The Ace-gclc and Ace-gclm cDNAs encode proteins with 655 and 254 amino acids and calculated molecular masses of 74.76 and 28.51kDa, respectively. The Ace-GCLC amino acid sequence shares about 70% identity and 80% sequence similarity with orthologs in Loa loa, Onchocerca volvulus, Brugia malayi, and Ascaris suum, whereas the Ace-GCLM amino acid sequence has only about 30% sequence identity and 50% similarity to homologous proteins in those species. Real-time PCR analysis of mRNA expression in L3, serum stimulated L3 and adult stages of A. ceylanicum showed the highest level of Ace-GCLC and Ace-GCLM expression occurred in adult worms. No differences were detected among adult hookworms harvested 21 and 35dpi indicating expression of Ace-gclc and Ace-gclm in adult worms is constant during the course of infection. Positive interaction between two subunits of glutamate-cysteine ligase was detected using the yeast two-hybrid system, and by specific enzymatic reaction. Ace-GCL is an intracellular enzyme and is not exposed to the host immune system. Thus, as expected, we did not detect IgG antibodies against Ace-GCLC or Ace-GCLM on days 21, 60 and 120 of A. ceylanicum infection in hamsters. Furthermore, vaccination with one or both antigens did not reduce worm burdens, and resulted in no improvement of clinical parameters (hematocrit and hemoglobin) of infected hamsters. Therefore, due to the significant role of the enzyme in parasite metabolism, our analyses raises hope for the development of a successful new drug against ancylostomiasis based on the specific GCL inhibitor.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Process

  4 / 1062 MEDLINE  
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[PMID]: 23727473
[Au] Autor:De Mello IN; Braga FR; Monteiro TS; Freitas LG; Araujo JM; Soares FE; Araújo JV
[Ad] Address:Departamento de Veterinária, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil. Electronic address: ingkramer@yahoo.com.br....
[Ti] Title:Biological control of infective larvae of Ancylostoma spp. in beach sand.
[So] Source:Rev Iberoam Micol;31(2):114-8, 2014 Apr-Jun.
[Is] ISSN:2173-9188
[Cp] Country of publication:Spain
[La] Language:eng
[Ab] Abstract:BACKGROUND: Geohelminths are parasites that stand out for their prevalence and wide distribution, depending on the soil for their transmission. AIMS: The aim of this work was to evaluate the predatory capacity of the fungal isolate of the genus Duddingtonia (CG768) on third stage larvae (L3) of Ancylostoma spp. in beach sand under laboratory conditions. METHODS: In the assay A five treatment groups and 1 control group were formed. The treatment groups contained 5000, 10,000, 15,000, 20,000 or 25,000 chlamydospores of the fungal isolate and 1000 Ancylostoma spp. L3 in pots containing 30g of sand. The control group (without fungus) contained only 1000 Ancylostoma spp. L3 and distilled water in pots with 30g of sand. RESULTS: Evidence of predatory activity was observed at the end of 15 days, where we observed the following percentages of reduction of L3: Group 1 (4.5%); Group 2 (24.5%); Group 3 (59.2%); Group 4 (58.8%); Group 5 (63%). However, difference was noted (p<0.01) only at concentrations 15,000, 20,000 and 25,000 in relation to control group. In the assay B two groups were formed in Petri dishes of 9cm in diameter containing agar water 2% medium. In the treated group, each Petri dish contained 500 Ancylostoma spp. L3 and 5g of sand containing the isolate CG 768 at a concentration of 25,000 chlamydospores/g of sand, and the control group (without fungus) contained only 500 L3. At the end of 7 days the non-predation L3 of Petri dishes using the method of Baermann were recovered. Difference (p<0.01) between groups on reducing the average number of Ancylostoma spp. L3 (percent reduction of 84%) was observed. CONCLUSIONS: The results of this study confirm earlier work on the efficiency of the Duddingtonia genus in the control of Ancylostoma spp. infective larvae.
[Mh] MeSH terms primary: Ancylostoma/growth & development
Ancylostomiasis/prevention & control
Bathing Beaches
Duddingtonia/physiology
Pest Control, Biological
Soil/parasitology
[Mh] MeSH terms secundary: Ancylostoma/microbiology
Animals
Brazil
Humans
Larva
Spores, Fungal
[Pt] Publication type:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Soil)
[Em] Entry month:1412
[Js] Journal subset:IM
[Da] Date of entry for processing:140416
[St] Status:MEDLINE

  5 / 1062 MEDLINE  
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[PMID]: 24891471
[Au] Autor:Ngui R; Lim YA; Ismail WH; Lim KN; Mahmud R
[Ad] Address:Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Parasite Southeast Asia Diagnostic (Para:SEAD) Laboratory, Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Sunway Medical Centre, No. 5, Jalan Lagoon Selatan,...
[Ti] Title:Zoonotic Ancylostoma ceylanicum infection detected by endoscopy.
[So] Source:Am J Trop Med Hyg;91(1):86-8, 2014 Jul.
[Is] ISSN:1476-1645
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:We report a case of Ancylostoma ceylanicum infection detected by endoscopy. It was diagnosed and confirmed using polymerase chain reaction (PCR) and DNA sequencing. The patient is a 58-year-old Malaysian woman who lives in a rural area, where uncontrolled populations of stray and semidomesticated dogs live in close proximity with humans.
[Mh] MeSH terms primary: Ancylostoma/isolation & purification
Ancylostomiasis/diagnosis
[Mh] MeSH terms secundary: Ancylostomiasis/pathology
Animals
Dogs
Endoscopy, Gastrointestinal
Female
Humans
Middle Aged
Zoonoses
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1409
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:140703
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.13-0756

  6 / 1062 MEDLINE  
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SciELO Brazil full text

[PMID]: 24879000
[Au] Autor:Casmo V; Augusto G; Nala R; Sabonete A; Carvalho-Costa FA
[Ad] Address:Laboratório de Parasitologia Intestinal e Vesical do Instituto Nacional de Saúde de Moçambique, Cidade de Maputo, Moçambique....
[Ti] Title:The effect of hookworm infection and urinary schistosomiasis on blood hemoglobin concentration of schoolchildren living in northern Mozambique.
[So] Source:Rev Inst Med Trop Sao Paulo;56(3):219-24, 2014 May-Jun.
[Is] ISSN:1678-9946
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:This study aims to assess the association between schistosomiasis and hookworm infection with hemoglobin levels of schoolchildren in northern Mozambique. Through a cross-sectional survey, 1,015 children from five to 12 years old in the provinces of Nampula, Cabo Delgado and Niassa were studied. Hookworm infection and urinary schistosomiasis were diagnosed, through Ritchie and filtration methods, with a prevalence of 31.3% and 59.1%, respectively. Hemoglobin levels were obtained with a portable photometer (Hemocue®). The average hemoglobin concentration was 10.8 ± 1.42 g/dL, and 62.1% of the children presented levels below 11.5 g/dL, of which 11.8% of the total number of children had hemoglobin levels below 9 g/dL. A multiple linear regression analysis demonstrated negative interactions between hemoglobin levels and ancylostomiasis, this being restricted to the province of Cabo Delgado (ß = -0.55; p < 0.001) where an independent interaction between hemoglobin levels and urinary schistosomiasis was also observed (ß = -0.35; p = 0.016). The logistical regression model indicated that hookworm infection represents a predictor of mild (OR = 1.87; 95% CI = 1.17-3.00) and moderate/severe anemia (OR = 2.71; 95% CI = 1.50 - 4.89). We concluded that, in the province of Cabo Delgado, hookworm and Schistosoma haematobium infections negatively influence hemoglobin levels in schoolchildren. Periodical deworming should be considered in the region. Health education and improvements in sanitary infrastructure could achieve long-term and sustainable reductions in soil-transmitted helminthiases and schistosomiasis prevalence rates.
[Mh] MeSH terms primary: Anemia/parasitology
Hemoglobin A/analysis
Hookworm Infections/complications
Schistosomiasis haematobia/complications
[Mh] MeSH terms secundary: Anemia/blood
Animals
Child
Child, Preschool
Female
Hookworm Infections/blood
Humans
Male
Mozambique
Schistosomiasis haematobia/blood
Severity of Illness Index
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:9034-51-9 (Hemoglobin A)
[Em] Entry month:1408
[Cu] Class update date: 141110
[Lr] Last revision date:141110
[Js] Journal subset:IM
[Da] Date of entry for processing:140602
[St] Status:MEDLINE

  7 / 1062 MEDLINE  
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[PMID]: 24768317
[Au] Autor:d'Ovidio D; Pepe P; Ianniello D; Noviello E; Quinton JF; Cringoli G; Rinaldi L
[Ad] Address:Private Practitioner, Naples, Italy....
[Ti] Title:First survey of endoparasites in pet ferrets in Italy.
[So] Source:Vet Parasitol;203(1-2):227-30, 2014 Jun 16.
[Is] ISSN:1873-2550
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Endoparasites are infrequently reported in ferrets. A cross-sectional survey was conducted to determine the prevalence of intestinal parasites in pet ferrets in southern Italy. Fresh fecal samples were randomly collected from 50 ferrets housed in pet shops or privately owned. All fecal samples were processed using the FLOTAC pellet technique to identify and count helminthic eggs/larvae and protozoan cysts/oocysts. In addition, the samples were analyzed also by the Remel XpectGiardia/Cryptosporidium immunoassay. Intestinal parasites were detected in 15 out of 50 ferrets (30%). Eggs of ancylostomids were found in 28.0% (14/50) of the animals and oocysts of Sarcocystis were detected in one ferret (2.0%). None of the samples was positive for Cryptosporidium or Giardia. To the authors' knowledge, this is the first report of sarcosporidiosis in a pet ferret in Italy.
[Mh] MeSH terms primary: Ancylostomiasis/veterinary
Ferrets/parasitology
Intestinal Diseases, Parasitic/veterinary
Parasitic Diseases, Animal/epidemiology
Pets/parasitology
Sarcocystosis/veterinary
[Mh] MeSH terms secundary: Ancylostoma
Ancylostomiasis/diagnosis
Ancylostomiasis/epidemiology
Animals
Cross-Sectional Studies
Feces/parasitology
Intestinal Diseases, Parasitic/epidemiology
Intestinal Diseases, Parasitic/parasitology
Italy
Parasite Egg Count
Parasitic Diseases, Animal/diagnosis
Parasitic Diseases, Animal/parasitology
Prevalence
Sarcocystis
Sarcocystosis/diagnosis
Sarcocystosis/epidemiology
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1406
[Js] Journal subset:IM
[Da] Date of entry for processing:140512
[St] Status:MEDLINE

  8 / 1062 MEDLINE  
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[PMID]: 24703073
[Au] Autor:Prullage JB; Knaus M; Bowman DD; Chester ST; Visser M; Rehbein S; Rosentel J
[Ad] Address:Merial Ltd., Duluth, GA 30096, USA. Electronic address: joseph.prullage@merial.com....
[Ti] Title:Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel against induced infections of Ancylostoma spp. nematodes of cats.
[So] Source:Vet Parasitol;202(1-2):30-3, 2014 Apr 28.
[Is] ISSN:1873-2550
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Four studies were conducted to examine the efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin, and praziquantel (BROADLINE(®), Merial) against Ancylostoma tubaeforme and Ancylostoma braziliense hookworms of cats. In each study, purpose-bred cats were randomly assigned to treatment groups of 10 or 12 cats per group. In three studies the cats were inoculated with A. tubaeforme and in one study with A. braziliense. The inoculations were undertaken on a schedule which resulted in the hookworms reaching the fourth larval stage in two of the studies, or the adult stage in four of the studies, by the day of treatment. In each study there was also an untreated control and 1 or 2 groups treated with the novel combination. In the two studies where efficacy against the fourth larval stage of A. tubaeforme was tested, the efficacy recorded was 100%. In the three studies where efficacy against the adult stage of A. tubaeforme was tested, efficacy of 100% was also confirmed. In the study where efficacy against the adult stage of A. braziliense was tested efficacy was 99.5%.
[Mh] MeSH terms primary: Ancylostomiasis/veterinary
Antiparasitic Agents/administration & dosage
Cat Diseases/drug therapy
[Mh] MeSH terms secundary: Ancylostoma/physiology
Ancylostomiasis/drug therapy
Animals
Cats
Drug Combinations
Ivermectin/administration & dosage
Ivermectin/analogs & derivatives
Methoprene/administration & dosage
Praziquantel/administration & dosage
Pyrazoles/administration & dosage
Random Allocation
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Antiparasitic Agents); 0 (Drug Combinations); 0 (Pyrazoles); 160902-72-7 (4''-epiacetylamino-4''-deoxyavermectin B1); 6490C9U457 (Praziquantel); 70288-86-7 (Ivermectin); 8B830OJ2UX (Methoprene); QGH063955F (fipronil)
[Em] Entry month:1406
[Js] Journal subset:IM
[Da] Date of entry for processing:140407
[St] Status:MEDLINE

  9 / 1062 MEDLINE  
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[PMID]: 24445211
[Au] Autor:Knopp S; Salim N; Schindler T; Karagiannis Voules DA; Rothen J; Lweno O; Mohammed AS; Singo R; Benninghoff M; Nsojo AA; Genton B; Daubenberger C
[Ad] Address:Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland; Department of Life Sciences, Natural History Museum, London, United Kingdom; Bagamoyo Research and Training Centre, Ifakara Health Institute, Bagamoyo, United Republic of Tanzania; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland; Division for Tropical Medicine and Infectious Diseases, Ludwig-Maximilians University Hospital, Munich, Germany; National Institute for Medical Research, Mbeya Medical Research Center, Mbeya, Tanzania.
[Ti] Title:Diagnostic accuracy of Kato-Katz, FLOTAC, Baermann, and PCR methods for the detection of light-intensity hookworm and Strongyloides stercoralis infections in Tanzania.
[So] Source:Am J Trop Med Hyg;90(3):535-45, 2014 Mar.
[Is] ISSN:1476-1645
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Sensitive diagnostic tools are crucial for an accurate assessment of helminth infections in low-endemicity areas. We examined stool samples from Tanzanian individuals and compared the diagnostic accuracy of a real-time polymerase chain reaction (PCR) with the FLOTAC technique and the Kato-Katz method for hookworm and the Baermann method for Strongyloides stercoralis detection. Only FLOTAC had a higher sensitivity than the Kato-Katz method for hookworm diagnosis; the sensitivities of PCR and the Kato-Katz method were equal. PCR had a very low sensitivity for S. stercoralis detection. The cycle threshold values of the PCR were negatively correlated with the logarithm of hookworm egg and S. stercoralis larvae counts. The median larvae count was significantly lower in PCR false negatives than true positives. All methods failed to detect very low-intensity infections. New diagnostic approaches are needed for monitoring of progressing helminth control programs, confirmation of elimination, or surveillance of disease recrudescence.
[Mh] MeSH terms primary: Helminthiasis/diagnosis
Helminths/genetics
Intestinal Diseases, Parasitic/diagnosis
Real-Time Polymerase Chain Reaction/methods
[Mh] MeSH terms secundary: Adolescent
Adult
Aged
Aged, 80 and over
Ancylostoma/genetics
Ancylostoma/isolation & purification
Ancylostomiasis/diagnosis
Animals
Ascariasis/diagnosis
Ascaris lumbricoides/genetics
Ascaris lumbricoides/isolation & purification
Child
Child, Preschool
DNA, Helminth/analysis
Feces/parasitology
Female
Helminths/isolation & purification
Humans
Infant
Larva
Male
Middle Aged
Necator americanus/genetics
Necator americanus/isolation & purification
Necatoriasis/diagnosis
Parasite Egg Count
Schistosoma mansoni/genetics
Schistosoma mansoni/isolation & purification
Schistosomiasis mansoni/diagnosis
Sensitivity and Specificity
Strongyloides stercoralis/genetics
Strongyloides stercoralis/isolation & purification
Strongyloidiasis/diagnosis
Tanzania
Trichuriasis/diagnosis
Trichuris/genetics
Trichuris/isolation & purification
Young Adult
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (DNA, Helminth)
[Em] Entry month:1404
[Cu] Class update date: 141111
[Lr] Last revision date:141111
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:140306
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.13-0268

  10 / 1062 MEDLINE  
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[PMID]: 24587473
[Au] Autor:McClure EM; Meshnick SR; Mungai P; Malhotra I; King CL; Goldenberg RL; Hudgens MG; Siega-Riz AM; Dent AE
[Ad] Address:Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America ; Research Triangle Institute, Durham, North Carolina, United States of America....
[Ti] Title:The association of parasitic infections in pregnancy and maternal and fetal anemia: a cohort study in coastal Kenya.
[So] Source:PLoS Negl Trop Dis;8(2):e2724, 2014 Feb.
[Is] ISSN:1935-2735
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Relative contribution of these infections on anemia in pregnancy is not certain. While measures to protect pregnant women against malaria have been scaling up, interventions against helminthes have received much less attention. In this study, we determine the relative impact of helminthes and malaria on maternal anemia. METHODS: A prospective observational study was conducted in coastal Kenya among a cohort of pregnant women who were recruited at their first antenatal care (ANC) visit and tested for malaria, hookworm, and other parasitic infections and anemia at enrollment. All women enrolled in the study received presumptive treatment with sulfadoxine-pyrimethamine, iron and multi-vitamins and women diagnosed with helminthic infections were treated with albendazole. Women delivering a live, term birth, were also tested for maternal anemia, fetal anemia and presence of infection at delivery. PRINCIPAL FINDINGS: Of the 706 women studied, at the first ANC visit, 27% had moderate/severe anemia and 71% of women were anemic overall. The infections with highest prevalence were hookworm (24%), urogenital schistosomiasis (17%), trichuria (10%), and malaria (9%). In adjusted and unadjusted analyses, moderate/severe anemia at first ANC visit was associated with the higher intensities of hookworm and P. falciparum microscopy-malaria infections. At delivery, 34% of women had moderate/severe anemia and 18% of infants' cord hemoglobin was consistent with fetal anemia. While none of the maternal infections were significantly associated with fetal anemia, moderate/severe maternal anemia was associated with fetal anemia. CONCLUSIONS: More than one quarter of women receiving standard ANC with IPTp for malaria had moderate/severe anemia in pregnancy and high rates of parasitic infection. Thus, addressing the role of co-infections, such as hookworm, as well as under-nutrition, and their contribution to anemia is needed.
[Mh] MeSH terms primary: Anemia/complications
Anemia/epidemiology
Pregnancy Complications, Parasitic/epidemiology
[Mh] MeSH terms secundary: Adult
Ancylostomiasis/complications
Ancylostomiasis/epidemiology
Animals
Female
Fetal Blood/chemistry
Hemoglobins/analysis
Humans
Kenya/epidemiology
Malaria/complications
Malaria/epidemiology
Pregnancy
Prospective Studies
Schistosomiasis/complications
Schistosomiasis/epidemiology
Young Adult
[Pt] Publication type:JOURNAL ARTICLE; OBSERVATIONAL STUDY; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Name of substance:0 (Hemoglobins)
[Em] Entry month:1411
[Cu] Class update date: 141111
[Lr] Last revision date:141111
[Js] Journal subset:IM
[Da] Date of entry for processing:140303
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0002724


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