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[PMID]: 25293765
[Au] Autor:Serafim LR; da Silva JP; de Paiva NC; dos Santos HA; Quintão Silva Mda G; Carneiro CM; Dias SR; Rabelo ÉM
[Ad] Address:Laboratório de Parasitologia Molecular, Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Pampulha, CEP 31270-901, Belo Horizonte, Minas Gerais, Brazil.
[Ti] Title:The crowding effect in Ancylostoma ceylanicum: density-dependent effects on an experimental model of infection.
[So] Source:Parasitol Res;113(12):4611-21, 2014 Dec.
[Is] ISSN:1432-1955
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:This study compared the course of Ancylostoma ceylanicum infection in hamsters infected with different inocula and the consequences for the host and helminth populations. The average of adult worms recovered, according to the number of third stage larva used, were 28.0, 24.8, 24.6, and 24.8% to inocula size of 25 L3, 75 L3, 125 L3, and 250 L3, respectively. The size of the inoculum did not affect the establishment, survival, or fecundity of adult helminths. Reductions in the red blood cell and hemoglobin levels in the infected group were inversely proportional to the number of white blood cells. Moreover, differential cell counting revealed a positive correlation between the worm load and leucocyte numbers. The humoral response against excretion-secretion antigens was more robust and sensitive compared with the response against crude extract, with no direct linear correlation with the number of worms. The effect of the population density was more evident in females.
[Mh] MeSH terms primary: Ancylostoma/physiology
Ancylostomiasis/parasitology
Antigens, Helminth/immunology
Host-Parasite Interactions
[Mh] MeSH terms secundary: Ancylostoma/anatomy & histology
Ancylostoma/growth & development
Ancylostoma/immunology
Ancylostomiasis/immunology
Ancylostomiasis/pathology
Animals
Blood Cell Count
Body Weight
Cricetinae
Disease Models, Animal
Female
Immunity, Humoral
Intestine, Small/pathology
Larva
Male
Parasite Egg Count
Parasite Load
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Antigens, Helminth)
[Em] Entry month:1506
[Js] Journal subset:IM
[Da] Date of entry for processing:141110
[St] Status:MEDLINE
[do] DOI:10.1007/s00436-014-4151-y

  2 / 1072 MEDLINE  
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[PMID]: 25730766
[Au] Autor:Schwarz EM; Hu Y; Antoshechkin I; Miller MM; Sternberg PW; Aroian RV
[Ad] Address:Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA....
[Ti] Title:The genome and transcriptome of the zoonotic hookworm Ancylostoma ceylanicum identify infection-specific gene families.
[So] Source:Nat Genet;47(4):416-22, 2015 Apr.
[Is] ISSN:1546-1718
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Hookworms infect over 400 million people, stunting and impoverishing them. Sequencing hookworm genomes and finding which genes they express during infection should help in devising new drugs or vaccines against hookworms. Unlike other hookworms, Ancylostoma ceylanicum infects both humans and other mammals, providing a laboratory model for hookworm disease. We determined an A. ceylanicum genome sequence of 313 Mb, with transcriptomic data throughout infection showing expression of 30,738 genes. Approximately 900 genes were upregulated during early infection in vivo, including ASPRs, a cryptic subfamily of activation-associated secreted proteins (ASPs). Genes downregulated during early infection included ion channels and G protein-coupled receptors; this downregulation was observed in both parasitic and free-living nematodes. Later, at the onset of heavy blood feeding, C-lectin genes were upregulated along with genes for secreted clade V proteins (SCVPs), encoding a previously undescribed protein family. These findings provide new drug and vaccine targets and should help elucidate hookworm pathogenesis.
[Mh] MeSH terms primary: Ancylostoma/genetics
Ancylostoma/pathogenicity
Ancylostomiasis/genetics
Genome, Helminth
Transcriptome
[Mh] MeSH terms secundary: Ancylostomatoidea/genetics
Ancylostomiasis/parasitology
Animals
Base Sequence
Female
Humans
Male
Molecular Sequence Data
Multigene Family
Phylogeny
Species Specificity
Zoonoses/genetics
Zoonoses/parasitology
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Entry month:1506
[Cu] Class update date: 150414
[Lr] Last revision date:150414
[Js] Journal subset:IM
[Da] Date of entry for processing:150327
[St] Status:MEDLINE
[do] DOI:10.1038/ng.3237

  3 / 1072 MEDLINE  
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[PMID]: 25745677
[Ti] Title:Soil-transmitted helminthiases: number of children treated in 2013.
[So] Source:Wkly Epidemiol Rec;90(10):89-94, 2015 Mar 6.
[Is] ISSN:0049-8114
[Cp] Country of publication:Switzerland
[La] Language:eng; fre
[Mh] MeSH terms primary: Ancylostomiasis/prevention & control
Anthelmintics/therapeutic use
Ascariasis/prevention & control
Necatoriasis/prevention & control
Primary Prevention/statistics & numerical data
Trichuriasis/prevention & control
[Mh] MeSH terms secundary: Adolescent
Albendazole/therapeutic use
Ancylostoma
Ancylostomiasis/transmission
Animals
Ascariasis/transmission
Ascaris lumbricoides
Child
Child, Preschool
Databases, Factual/statistics & numerical data
Global Health
Humans
Infant
Mebendazole/therapeutic use
Necator americanus
Necatoriasis/transmission
Soil/parasitology
Trichuriasis/transmission
Trichuris
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Anthelmintics); 0 (Soil); 81G6I5V05I (Mebendazole); F4216019LN (Albendazole)
[Em] Entry month:1505
[Js] Journal subset:IM
[Da] Date of entry for processing:150306
[St] Status:MEDLINE

  4 / 1072 MEDLINE  
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[PMID]: 25092620
[Au] Autor:Wisniewski M; Lapinski M; Zdziarska A; Dlugosz E; Baska P
[Ad] Address:Division of Parasitology and Parasitic Diseases, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Ciszewskiego 8, 02-786 Warsaw, Poland. Electronic address: marcin_wisniewski@sggw.pl....
[Ti] Title:Molecular cloning and analysis of Ancylostoma ceylanicum glutamate-cysteine ligase.
[So] Source:Mol Biochem Parasitol;196(1):12-20, 2014 Aug.
[Is] ISSN:1872-9428
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Glutamate-cysteine ligase (GCL) is a heterodimer enzyme composed of a catalytic subunit (GCLC) and a modifier subunit (GCLM). This enzyme catalyses the synthesis of γ-glutamylcysteine, a precursor of glutathione. cDNAs of the putative glutamate-cysteine ligase catalytic (Ace-GCLC) and modifier subunits (Ace-GCLM) of Ancylostoma ceylanicum were cloned using the RACE-PCR amplification method. The Ace-gclc and Ace-gclm cDNAs encode proteins with 655 and 254 amino acids and calculated molecular masses of 74.76 and 28.51kDa, respectively. The Ace-GCLC amino acid sequence shares about 70% identity and 80% sequence similarity with orthologs in Loa loa, Onchocerca volvulus, Brugia malayi, and Ascaris suum, whereas the Ace-GCLM amino acid sequence has only about 30% sequence identity and 50% similarity to homologous proteins in those species. Real-time PCR analysis of mRNA expression in L3, serum stimulated L3 and adult stages of A. ceylanicum showed the highest level of Ace-GCLC and Ace-GCLM expression occurred in adult worms. No differences were detected among adult hookworms harvested 21 and 35dpi indicating expression of Ace-gclc and Ace-gclm in adult worms is constant during the course of infection. Positive interaction between two subunits of glutamate-cysteine ligase was detected using the yeast two-hybrid system, and by specific enzymatic reaction. Ace-GCL is an intracellular enzyme and is not exposed to the host immune system. Thus, as expected, we did not detect IgG antibodies against Ace-GCLC or Ace-GCLM on days 21, 60 and 120 of A. ceylanicum infection in hamsters. Furthermore, vaccination with one or both antigens did not reduce worm burdens, and resulted in no improvement of clinical parameters (hematocrit and hemoglobin) of infected hamsters. Therefore, due to the significant role of the enzyme in parasite metabolism, our analyses raises hope for the development of a successful new drug against ancylostomiasis based on the specific GCL inhibitor.
[Mh] MeSH terms primary: Ancylostoma/enzymology
Glutamate-Cysteine Ligase/genetics
Glutamate-Cysteine Ligase/metabolism
[Mh] MeSH terms secundary: Ancylostoma/genetics
Ancylostomiasis/immunology
Ancylostomiasis/prevention & control
Animals
Antibodies, Helminth
Ascaris suum/enzymology
Ascaris suum/genetics
Brugia malayi/enzymology
Brugia malayi/genetics
Cloning, Molecular
Cricetinae
Disease Models, Animal
Gene Expression Profiling
Glutamate-Cysteine Ligase/chemistry
Glutamate-Cysteine Ligase/immunology
Immunoglobulin G/blood
Molecular Weight
Onchocerca volvulus/enzymology
Onchocerca volvulus/genetics
Protein Binding
Protein Interaction Mapping
Protein Subunits/chemistry
Protein Subunits/genetics
Protein Subunits/metabolism
Real-Time Polymerase Chain Reaction
Sequence Homology, Amino Acid
Two-Hybrid System Techniques
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Antibodies, Helminth); 0 (Immunoglobulin G); 0 (Protein Subunits); EC 6.3.2.2 (Glutamate-Cysteine Ligase)
[Em] Entry month:1505
[Js] Journal subset:IM
[Da] Date of entry for processing:140906
[St] Status:MEDLINE

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[PMID]: 25618132
[Au] Autor:George S; Kaliappan SP; Kattula D; Roy S; Geldhof P; Kang G; Vercruysse J; Levecke B
[Ad] Address:Department of Virology, Parasitology and Immunology, Ghent University, Faculty of Veterinary Medicine, Merelbeke, Belgium Division of Gastrointestinal Sciences, Christian Medical College, Vellore, India....
[Ti] Title:Identification of Ancylostoma ceylanicum in children from a tribal community in Tamil Nadu, India using a semi-nested PCR-RFLP tool.
[So] Source:Trans R Soc Trop Med Hyg;109(4):283-5, 2015 Apr.
[Is] ISSN:1878-3503
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: It is generally assumed that hookworm infections in humans are caused by Necator americanus and Ancylostoma duodenale. However, previous studies have also reported the presence of the animal hookworm A. ceylanicum in human stools. METHODS: We determined hookworm infections in children in a tribal community in Tamil Nadu, India, using a semi-nested PCR-RFLP approach. RESULTS: The results indicate that human species account for a majority of the hookworm infections (N. americanus 39/41 [95%]; A. duodenale 6/41 [15%]), whereas the animal hookworm A. ceylanicum only accounts for a minority of the infections (5%; 2/41). CONCLUSIONS: The results emphasize the need to consider zoonotic ancylostomiasis while developing strategies to control hookworm infections.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1503
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1093/trstmh/trv001

  6 / 1072 MEDLINE  
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[PMID]: 25521874
[Au] Autor:Gonzalez AR; Fee E
[Ad] Address:Ana Rita Gonzalez is with Policy Wisdom LLC, Miami, FL. Elizabeth Fee is with the National Library of Medicine, National Institutes of Health, Bethesda, MD.
[Ti] Title:Anemia in Puerto Rico at the turn of the twentieth century.
[So] Source:Am J Public Health;105(2):272-3, 2015 Feb.
[Is] ISSN:1541-0048
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Anemia/history
[Mh] MeSH terms secundary: Ancylostoma
Ancylostomiasis/complications
Ancylostomiasis/epidemiology
Ancylostomiasis/history
Anemia/epidemiology
Anemia/etiology
Anemia/prevention & control
Animals
History, 19th Century
History, 20th Century
Humans
Public Health/history
Puerto Rico/epidemiology
[Pt] Publication type:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE; PORTRAITS
[Ps] Personal name as subject:Ashford BK
[Em] Entry month:1504
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:150110
[St] Status:MEDLINE
[do] DOI:10.2105/AJPH.2014.302225

  7 / 1072 MEDLINE  
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[PMID]: 24862060
[Au] Autor:Deesomsak M; Sawanyawisuth K; Prachayakul V
[Ad] Address:Division of Gastroenterology, Department of Internal Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
[Ti] Title:An unusual cause of chronic diarrhoea.
[So] Source:Trop Biomed;31(1):187-9, 2014 Mar.
[Is] ISSN:0127-5720
[Cp] Country of publication:Malaysia
[La] Language:eng
[Ab] Abstract:We report a patient presenting with chronic diarrhoea of unidentified etiology. Laboratory results showed microcytic anemia, peripheral eosinophilia with negative results of stool sample smears and stool concentration technique. Ancylostoma duodenale was found in the caecum and terminal ileum during colonoscopy. The patient was treated with a 3-day course of 400 mg albendazole and iron supplement. The diarrhoea disappeared shortly after treatment. Physicians particularly in tropical areas should be aware of hookworms as causative agents of chronic diarrhoea and it may be found in the large intestine.
[Mh] MeSH terms primary: Albendazole/administration & dosage
Ancylostomiasis/diagnosis
Anthelmintics/administration & dosage
Diarrhea/diagnosis
Dietary Supplements
Iron/metabolism
[Mh] MeSH terms secundary: Adult
Ancylostoma/isolation & purification
Ancylostomiasis/drug therapy
Ancylostomiasis/parasitology
Animals
Cecum/parasitology
Chronic Disease
Colonoscopy
Diarrhea/drug therapy
Diarrhea/parasitology
Female
Humans
Ileum/parasitology
Thailand
Treatment Outcome
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Anthelmintics); E1UOL152H7 (Iron); F4216019LN (Albendazole)
[Em] Entry month:1504
[Js] Journal subset:IM
[Da] Date of entry for processing:140527
[St] Status:MEDLINE

  8 / 1072 MEDLINE  
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[PMID]: 23375194
[Au] Autor:Bienhoff SE; Kok DJ; Roycroft LM; Roberts ES
[Ad] Address:Novartis Animal Health US, Inc., 3200 Northline Avenue, Suite 300, Greensboro, NC 27408, USA. stephen.bienhoff@novartis.com
[Ti] Title:Efficacy of a single oral administration of milbemycin oxime against natural infections of Ancylostoma braziliense in dogs.
[So] Source:Vet Parasitol;195(1-2):102-5, 2013 Jul 1.
[Is] ISSN:1873-2550
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:The objective of this randomized, blinded, placebo controlled laboratory study was to confirm the efficacy of a single oral administration of two marketed formulations of milbemycin oxime (Interceptor(®) Flavor Tabs(®) and Sentinel(®) Flavor Tabs(®)) at a minimum dose of 0.5 mg/kg (0.23 mg/lb) against natural infections of Ancylostoma braziliense in dogs. Thirty-six hookworm infected dogs, a minimum of 10 weeks of age and of various breeds and genders were used. Fecal egg counts were done on three separate days prior to treatment for randomization purposes. Dogs were ranked by descending order of the fecal egg count arithmetic means and randomly assigned to either the two milbemycin treatment groups or the placebo control group in blocks of three dogs each, 12 dogs per group. Dogs were dosed according to the product label with blinding maintained by separation of function. Worm counts were done at necropsy 7 days after treatment. Reduction in A. braziliense worm counts in the milbemycin groups were compared to the placebo control group using analysis of variance of the A. braziliense logarithmic mean worm counts and percent efficacy was based on geometric means. Efficacy was defined as the ability of the test products to significantly (p≤0.05) reduce parasite load by 90% or greater in treated dogs when compared to adequately infected placebo control dogs. The placebo control group had a geometric mean worm count of 19.2. The Interceptor treated group had a geometric mean worm count of 0.38 representing a 98% reduction in parasite load and the Sentinel treated group had a geometric mean worm count of 0.98 representing a 95% reduction in parasite load. Both reductions were highly significant (p<0.0001). In this study, milbemycin oxime, when administered as two marketed formulations at a minimum dose of 0.5 mg/kg (0.23 mg/lb), was efficacious for removing adult A. braziliense in naturally infected dogs.
[Mh] MeSH terms primary: Ancylostoma/drug effects
Ancylostomiasis/veterinary
Anthelmintics/administration & dosage
Dog Diseases/drug therapy
Macrolides/administration & dosage
[Mh] MeSH terms secundary: Administration, Oral
Ancylostomiasis/drug therapy
Ancylostomiasis/parasitology
Animals
Dog Diseases/parasitology
Dogs
Feces/parasitology
Female
Male
Parasite Egg Count/veterinary
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Name of substance:0 (Anthelmintics); 0 (Macrolides); 129496-10-2 (milbemycin oxime)
[Em] Entry month:1503
[Js] Journal subset:IM
[Da] Date of entry for processing:130603
[St] Status:MEDLINE

  9 / 1072 MEDLINE  
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[PMID]: 25606735
[Au] Autor:Korndörfer AP
[Ad] Address:Universidade do Vale do Rio dos Sinos.
[Ti] Title:Para além do combate à ancilostomíase: o diário do médico norte-americano Alan Gregg. [Looking beyond the campaign to eradicate ancylostomiasis: the diary of the American physician Alan Gregg].
[So] Source:Hist Cienc Saude Manguinhos;21(4):1457-66, 2014 Oct-Dec.
[Is] ISSN:1678-4758
[Cp] Country of publication:Brazil
[La] Language:por
[Ab] Abstract:Between 1916 and 1923, the Federal District and 11 Brazilian states entered into cooperation agreements with the International Health Board of the Rockefeller Foundation to combat a rural endemic disease, namely ancylostomiasis. This paper presents the diary of Alan Gregg, one of the American physicians who worked in Brazil from 1919 to 1922. An interesting source to discuss issues relating to the history of public health in Brazil, in addition to information about the activities to combat ancylostomiasis developed by the Rockefeller Foundation in the country, the diary of the physician presents his impressions concerning nature, culture, politics and society in Brazil. In the diary excerpts presented here, however, aspects related to the professional activities performed by Gregg are prioritized.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1501
[Js] Journal subset:QIS
[St] Status:In-Process

  10 / 1072 MEDLINE  
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[PMID]: 25672202
[Au] Autor:Asif M; Aziz T; Altaf S; Sattar RA
[Ti] Title:Laurence Moon Bardet Biedl Syndrome with anaemia.
[So] Source:J Ayub Med Coll Abbottabad;26(4):625-7, 2014 Oct-Dec.
[Is] ISSN:1025-9589
[Cp] Country of publication:Pakistan
[La] Language:eng
[Ab] Abstract:Laurence Moon Bardet Biedl Syndrome is a rare genetic disorder. Consanguineous marriage is usually the common cause. Principal features of Bardet Biedl Syndrome are red cone dystrophy, obesity, polydactyl, hypogonadism and renal anomalies. The diagnosis was overlooked in our patient until he came in our hospital. We here report an infrequent case of autosomal recessive disorder with Anaemia.
[Mh] MeSH terms primary: Ancylostomiasis/complications
Anemia/parasitology
Bardet-Biedl Syndrome/complications
Bardet-Biedl Syndrome/diagnosis
[Mh] MeSH terms secundary: Adolescent
Ancylostomiasis/diagnosis
Humans
Male
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1503
[Js] Journal subset:IM
[Da] Date of entry for processing:150212
[St] Status:MEDLINE


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