Database : MEDLINE
Search on : apocynaceae [Words]
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[PMID]: 29496577
[Au] Autor:Zhao YL; Yang ZF; Shang JH; Huang WY; Wang B; Wei X; Khan A; Yuan ZW; Liu YP; Wang YF; Wang XH; Luo XD
[Ad] Address:State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
[Ti] Title:Effects of indole alkaloids from leaf of Alstonia scholaris on post-infectious cough in mice.
[So] Source:J Ethnopharmacol;218:69-75, 2018 Feb 26.
[Is] ISSN:1872-7573
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:ETHNOPHARMACOLOGICAL RELEVANCE: Leaf of Alstonia scholaris (L.) R. Br. (Apocynaceae), a wide used ethic-medicine in many Asia and Africa counties, has also been recorded as the common traditional Chinese medicine for treatment of illnesses in respiratory system by Dai people. AIM OF THE STUDY: To provide experimental data of clinical adaption of total indole alkaloids (TA) from leaf of A. scholaris for treating post-infectious cough in phase II clinical trial. MATERIALS AND METHODS: To model post-infectious cough, all animals except control group were instilled intra-tracheal with lipopolysaccharide (LPS) (80 µg/50 µL/mouse), followed by subsequent exposure to cigarette smoke (CS) for 30 min per day for a total of 30 days. Mice were orally given TA at dose of 10, 25, 50 mg/kg, and four main alkaloids (Sch: scholaricine, Epi: 19-epischolaricine, Val: vallesamine, Pic: picrinine) once daily. Cellular infiltration was assessed in the broncho-alveolar lavage fluid (BALF). Expression of interleukin-6 (IL-6) and C-reactive protein (CRP) in the serum was determined, the superoxide dismutase (SOD) activity as well as malondialdehyde (MDA) content in the serum and homogenate were examined. Finally, histopathological examination in the lungs was assessed by H. E. staining. RESULTS: After administration of TA and four major alkaloids respectively, the symptoms of cough in mice were obviously attenuated. Total white blood cells (WBC) and neutrophils (NEU) amounts in BALF were reduced obviously and the pathological damage of lung was also attenuated. There was also significant reduction in IL-6, CRP, MDA and a marked improvement in SOD. CONCLUSIONS: The efficacy of indole alkaloids against post-infectious cough (PIC) was shown in the down-regulation of inflammatory cells, cytokines, and the balance of antioxidants. What's more, the pharmacological effects of TA were better than single indole alkaloid, which might be related to the synergic effect of four major alkaloids.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  2 / 1353 MEDLINE  
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[PMID]: 29477369
[Au] Autor:Odoh UE; Uzor PF; Eze CL; Akunne TC; Onyegbulam CM; Osadebe PO
[Ad] Address:Department of Pharmacognosy and Environmental Medicines, University of Nigeria, Nsukka 410001, Nigeria.
[Ti] Title:Medicinal plants used by the people of Nsukka Local Government Area, south-eastern Nigeria for the treatment of malaria: An ethnobotanical survey.
[So] Source:J Ethnopharmacol;218:1-15, 2018 Feb 28.
[Is] ISSN:1872-7573
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:ETHNOBOTANICAL RELEVANCE: Malaria is a serious public health problem especially in sub-Saharan African countries such as Nigeria. The causative parasite is increasingly developing resistance to the existing drugs. There is urgent need for alternative and affordable therapy from medicinal plants which have been used by the indigenous people for many years. AIM OF STUDY: This study was conducted to document the medicinal plant species traditionally used by the people of Nsukka Local Government Area in south-eastern Nigeria for the treatment of malaria. METHODS: A total of 213 respondents, represented by women (59.2%) and men (40.8%), were interviewed using a semi-structured questionnaire. The results were analysed and discussed in the context of previously published information on anti-malarial and phytochemical studies of the identified plants. RESULTS: The survey revealed that 50 plant species belonging to 30 botanical families were used in this region for the treatment of malaria. The most cited families were Apocynaceae (13.3%), Annonaceae (10.0%), Asteraceae (10.0%), Lamiaceae (10.0%), Poaceae (10.0%), Rubiaceae (10.0%) and Rutaceae (10.0%). The most cited plant species were Azadirachta indica (11.3%), Mangifera indica (9.1%), Carica papaya (8.5%), Cymbopogon citratus (8.5%) and Psidium guajava (8.5%). CONCLUSION: The present findings showed that the people of Nsukka use a large variety of plants for the treatment of malaria. The identified plants are currently undergoing screening for anti-malarial, toxicity and chemical studies in our laboratory.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  3 / 1353 MEDLINE  
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[PMID]: 29484402
[Au] Autor:Hamam F; Eldalo A; Abdallah Q; Al-Deeb I; Alzahrani S; Alwagdani A; Alotaibi A; Nasr AR; Gouda Y; Mohamed K
[Ad] Address:Department of Pharmacology and Toxicology, College of Pharmacy, Taif University, Taif, Makkah 21974, Kingdom of Saudi Arabia.
[Ti] Title:Pharmacological activities of a novel plant species, Huernia Sp. Nov. aff. Boleana growing in the high mountains of southwest Saudi Arabia.
[So] Source:Mol Med Rep;17(4):6059-6067, 2018 Apr.
[Is] ISSN:1791-3004
[Cp] Country of publication:Greece
[La] Language:eng
[Ab] Abstract:Huernia Sp. Nov. aff. Boleana, Apocynaceae, grows in the high mountains of southwest Saudi Arabia and is widely used as a remedy for the treatment of diabetes. The present study investigated the anti­inflammatory, wound healing and inhibitory effects on migration of Huernia Sp. Nov. aff. Boleana. The anti­inflammatory effect was assessed in mice using formalin­induced edema. Wound healing effects were assessed in rats using a circular excision wound model. An in vitro 'scratch' test was used to investigate the inhibitory effects on melanoma cell (B16­F10) migration. The anti­inflammatory effects of total extract, hexane and chloroform fractions were greater or equal to indomethacin (control). The relatively non­polar fractions (hexane and chloroform) exhibited higher anti­inflammatory activities compared with the aqueous fraction. The percentage of wound contraction among animals treated with the plant extract was higher compared with the control; however, this difference was not statistically significant (P>0.05). The total plant extract increased wound healing by inhibiting the inflammatory response, promoting angiogenesis, and significantly promoting the proliferation of fibroblasts, particularly on days 7 and 14 post­wounding. Furthermore, the plant extract promoted wound repair via the enhancement of collagen synthesis, and complete epithelization with well­formed and differentiated epithelial tissues. The in vitro 'scratch' test indicated the inhibitory effects of this plant on melanoma cell migration in a dose­dependent manner. The present study indicated that Huernia Sp. Nov. aff. Boleana may have potential as an anti­inflammatory, wound-healing and migration-inhibiting ethno medicine.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Process
[do] DOI:10.3892/mmr.2018.8607

  4 / 1353 MEDLINE  
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[PMID]: 29510358
[Au] Autor:Alyahya SA; Govindarajan M; Alharbi NS; Kadaikunnan S; Khaled JM; Mothana RA; Al-Anbr MN; Vaseeharan B; Ishwarya R; Yazhiniprabha M; Benelli G
[Ad] Address:National Center for Biotechnology, King Abdulaziz City for Science and Technology, Riyadh 11442, Saudi Arabia.
[Ti] Title:Swift fabrication of Ag nanostructures using a colloidal solution of Holostemma ada-kodien (Apocynaceae) - Antibiofilm potential, insecticidal activity against mosquitoes and non-target impact on water bugs.
[So] Source:J Photochem Photobiol B;181:70-79, 2018 Feb 17.
[Is] ISSN:1873-2682
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Recent research in entomology and parasitology focused on the efficacy of green fabricated nanomaterials as novel insecticides. In this study, we synthesized poly-dispersed and stable silver nanoparticles (AgNPs) using the leaf extract of Holostemma ada-kodien. The nanostructures were characterized by ultraviolet-visible spectroscopy, Fourier-transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, energy dispersive X-ray, and X-ray diffraction analysis. The efficacy of H. ada-kodien leaf extract and AgNPs in vector control was evaluated against the mosquitoes Anopheles stephensi, Aedes aegypti, and Culex quinquefasciatus, which act as major vectors of important parasitic and arboviral diseases. AgNPs showed higher toxicity if compared to the H. ada-kodien leaf aqueous extract, LC towards larvae of A. stephensi, A. aegypti, and C. quinquefasciatus were 12.18, 13.30, and 14.70 µg/mL, respectively. When the AgNPs were tested on non-target water bugs, Diplonychus indicus, the LC value was 623.48 µg/mL. Furthermore, 100 µl/mL of AgNPs achieved significant antimicrobial activity against Bacillus pumilus, Enterococcus faecalis, Pseudomonas aeruginosa, Proteus vulgaris, and Candida albicans. Light and confocal laser scanning microscopy highlighted a major impact of the H. ada-kodien-synthesized AgNPs on the external topography and architecture of microbial biofilms, both on Gram-positive and Gram-negative bacteria. Overall, this study sheds light on the insecticidal and antibiofilm potential of H. ada-kodien-synthesized AgNPs, a potential green resource for the rapid synthesis of polydispersed and highly stable AgNPs.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:Publisher

  5 / 1353 MEDLINE  
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[PMID]: 29495249
[Au] Autor:Marques JI; Alves JSF; Torres-Rêgo M; Furtado AA; Siqueira EMDS; Galinari E; Araújo DFS; Guerra GCB; Azevedo EP; Fernandes-Pedrosa MF; Zucolotto SM
[Ad] Address:Laboratory of Pharmacognosy (PNBio), Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Avenida General Gustavo Cordeiro de Farias, S/N, Petrópolis 59012-570, Natal, Brazil. ivanbiotecnologo@hotmail.com.
[Ti] Title:Phytochemical Analysis by HPLC-HRESI-MS and Anti-Inflammatory Activity of Tabernaemontana catharinensis.
[So] Source:Int J Mol Sci;19(2), 2018 Feb 24.
[Is] ISSN:1422-0067
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:(Apocynaceae) has been popularly used by folk medicine because of its anti-inflammatory, analgesic, and antiophidic properties. This study aims to analyze the flavonoids composition of the hydroethanolic extract and of the ethyl acetate (EtOAc) and butanol (BuOH) fractions of leaves, as well as to evaluate their anti-inflammatory activity using in vivo models. The phytochemical profile, determined by High-Performance Liquid Chromatography-High-Resolution Electrospray Ionization-Mass Spectrometry (HPLC-HRESI-MS), showed the presence of flavonoids mainly having an isorhamnetin nucleus. The anti-inflammatory activity was evaluated in carrageenan-induced paw edema (pre- and post-treatment) with oral administration of a hydroethanolic extract (50, 100, and 150 mg/kg) and of organic fractions (50 mg/kg). The extract and fractions showed antiedematogenic activity by decreasing myeloperoxidase (MPO) production. In the zymosan-air-pouch model, the extract and fractions inhibited leukocyte migration and significantly decreased the levels of various proteins, such as MPO, interleukin (IL)-1ß, and tumor necrosis factor (TNF)-α. The cytotoxicity was evaluated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, which revealed no cytotoxicity of the extract and the fractions. These results suggest that the hydroethanolic extract and organic fractions of leaves have sufficient anti-inflammatory activity to support the popular use of this plant in the treatment of inflammatory disorders.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:In-Process

  6 / 1353 MEDLINE  
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[PMID]: 29479722
[Au] Autor:Livshultz T; Kaltenegger E; Straub SCK; Weitemier K; Hirsch E; Koval K; Mema L; Liston A
[Ad] Address:Department of Biodiversity, Earth, and Environmental Sciences, Academy of Natural Sciences of Drexel University, 1900 Benjamin Franklin Parkway, Philadelphia, PA, 19103, USA.
[Ti] Title:Evolution of pyrrolizidine alkaloid biosynthesis in Apocynaceae: revisiting the defence de-escalation hypothesis.
[So] Source:New Phytol;, 2018 Feb 26.
[Is] ISSN:1469-8137
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Plants produce specialized metabolites for their defence. However, specialist herbivores adapt to these compounds and use them for their own benefit. Plants attacked predominantly by specialists may be under selection to reduce or eliminate production of co-opted chemicals: the defence de-escalation hypothesis. We studied the evolution of pyrrolizidine alkaloids (PAs) in Apocynaceae, larval host plants for PA-adapted butterflies (Danainae, milkweed and clearwing butterflies), to test if the evolutionary pattern is consistent with de-escalation. We used the first PA biosynthesis specific enzyme (homospermidine synthase, HSS) as tool for reconstructing PA evolution. We found hss orthologues in diverse Apocynaceae species, not all of them known to produce PAs. The phylogenetic analysis showed a monophyletic origin of the putative hss sequences early in the evolution of one Apocynaceae lineage (the APSA clade). We found an hss pseudogene in Asclepias syriaca, a species known to produce cardiac glycosides but no PAs, and four losses of an HSS amino acid motif. APSA clade species are significantly more likely to be Danainae larval host plants than expected if all Apocynaceae species were equally likely to be exploited. Our findings are consistent with PA de-escalation as an adaptive response to specialist attack.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180226
[Lr] Last revision date:180226
[St] Status:Publisher
[do] DOI:10.1111/nph.15061

  7 / 1353 MEDLINE  
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[PMID]: 28452946
[Au] Autor:Li Y; Zhao Y; Zhou X; Ni W; Dai Z; Yang D; Hao J; Luo L; Liu Y; Luo X; Zhao X
[Ad] Address:Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, 21 Qingsong Road, Kunming 650203, China. liyuan@mail.kiz.ac.cn.
[Ti] Title:Cytotoxic Indole Alkaloid 3α-Acetonyltabersonine Induces Glioblastoma Apoptosis via Inhibition of DNA Damage Repair.
[So] Source:Toxins (Basel);9(5), 2017 Apr 28.
[Is] ISSN:2072-6651
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Cytotoxic indole alkaloids from , which belongs to the toxic plant family Apocynaceae, demonstrated impressive antitumor activities in many tumor types, but less application in glioblastoma, which is the lethal brain tumor. In the present study, we reported the anti-glioblastoma activity of an indole alkaloid, 3 -acetonyltabersonine, which was isolated from . 3 -acetonyltabersonine was cytotoxic to glioblastoma cell lines (U87 and T98G) and stem cells at low concentrations. We verified 3 -acetonyltabersonine could suppress tumor cell proliferation and cause apoptosis in glioblastoma stem cells (GSCs). Moreover, detailed investigation of transcriptome study and Western blotting analysis indicated the mitogen activated protein kinase (MAPK) pathway was activated by phosphorylation upon 3 -acetonyltabersonine treatment. Additionally, we found 3 -acetonyltabersonine inhibited DNA damage repair procedures, the accumulated DNA damage stimulated activation of MAPK pathway and, finally, induced apoptosis. Further evidence was consistently obtained from vivo experiments on glioblastoma mouse model: treatment of 3 -acetonyltabersonine could exert pro-apoptotic function and prolong the life span of tumor-bearing mice. These results in vitro and in vivo suggested that 3 -acetonyltabersonine could be a potential candidate antitumor agent.
[Mh] MeSH terms primary: Antineoplastic Agents/pharmacology
Cytotoxins/pharmacology
Glioblastoma/genetics
Indole Alkaloids/pharmacology
[Mh] MeSH terms secundary: Animals
Antineoplastic Agents/therapeutic use
Apoptosis/drug effects
Cell Line, Tumor
Cell Proliferation/drug effects
DNA Damage
DNA Repair/drug effects
Glioblastoma/drug therapy
Humans
Indole Alkaloids/therapeutic use
Male
Mice, Inbred C57BL
Mitogen-Activated Protein Kinases/metabolism
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antineoplastic Agents); 0 (Cytotoxins); 0 (Indole Alkaloids); EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[Js] Journal subset:IM
[Da] Date of entry for processing:170429
[St] Status:MEDLINE

  8 / 1353 MEDLINE  
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[PMID]: 29451754
[Au] Autor:Ferreira KR; Gomes ES; Rodrigues SR
[Ti] Title:Biological aspects and mating behavior of Leucothyreus albopilosus (Coleoptera: Scarabaeidae).
[So] Source:Rev Biol Trop;64(2):547-57, 2016 Jun.
[Is] ISSN:0034-7744
[Cp] Country of publication:Costa Rica
[La] Language:eng
[Ab] Abstract:The genus Leucothyreus has been linked to some commercial plant crop pests. Eventhough several species have been described for this genus, information about this group is still scarce. This study investigated some biological aspects and mating behavior in Leucothyreus albopilosus. Studies were conducted at the State University of Mato Grosso do Sul, in the municipalities of Aquidauana and Cassilândia, MS, Brazil. For biological studies, adults were collected with light traps from February 2011 to February 2012, and for behavior analyses from September to December 2014. Biological studies were undertaken every three days and included the eggs inspection, and the separation of the newly hatched larvae to observe and describe their developmental stages; to monitor larval growth and differentiate larval instars, we measured the larvae cephalic capsule. Life cycle was determined starting from the newly laid eggs until adult death. For mating behavior studies, adults obtained with light traps were taken to the laboratory. As soon as they started flying in the evening, couples were formed and copulation steps were recorded. In the field, we observed that adults were mostly collected during warmer and wetter periods (from August to March). Our results showed that the embryonic period of L. albopilosus lasted 20.5 days, the 1st, 2nd and 3rd instars lasted 31.0, 33.1 and 85.6 days, respectively. The pupal stage lasted 20 days, and the egg to adult period was completed in 185.5 days; these results suggest that L. albopilosus can be characterized as a univoltine species. Observations of mating behavior in the laboratory showed that, after the sunset, adults projected a small portion of clypeus near the soil surface and flew off seeking a female to mate. The female could accept or reject the male for mating. When the female accepted the male, copulation occurred from 19:00 to 23:00 hours, and lasted 19.45 minutes on average. Sometimes females refused to mate, probably because the male or female were not sexually mature to perform copulation, and there might be a chemical communication between the adults. Adults were observed feeding on ripe bananas (Musa sp., Musaceae) and on mangaba flowers (Hancornia speciosa, Apocynaceae) in the laboratory. With this work we contributed with the description of mating behavior in the genus Leucothyreus and concluded that the biological cycle was completed in less than 200 days.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1802
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[St] Status:In-Process

  9 / 1353 MEDLINE  
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[PMID]: 29441896
[Au] Autor:Lü L; Zhang D; Sun B; Hu Y; Yan M; Liu K; Li X; Ren L
[Ti] Title:Apocynum leaf extract inhibits the progress of atherosclerosis in rats via the AMPK/mTOR pathway.
[So] Source:Pharmazie;72(1):41-48, 2017 Jan 10.
[Is] ISSN:0031-7144
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Apocynum leaf extract is an extract of the dried leaves of Apocynum venetum (a member of the Apocynaceae family) that has many effects on the cardiovascular system. The aim of the present study was to evaluate the protective effects of apocynum leaf extract on the atherosclerosis in rats induced by high-fat diet combined with vitamin D3 intraperitoneal injection. The atherosclerosis in rats were induced with a high-fat diet and an intraperitoneal injection of VD3 once daily for three contiguous days at a total injection dose of 70 U/kg. At the end of the 18th week, serum total cholesterol (TC) and triglyceride (TG) contents were measured. Hydroxyproline content in the aorta were measured by the alkali hydrolysis method. The hematoxylin-eosin (HE) and immunohistochemical staining were applied to evaluate the morphological changes and the collagen I and α-smooth muscle actin expression. The protein expression and the mRNA level of AMPK and mTOR were detected by western blot analysis and reverse transcript PCR. After treatment with apocynum leaf extract, the serum total cholesterol and triglyceride concentration of the atherosclerotic rats were significantly decreased, both the Collagen I expression and the hydroxyproline content in the aorta were significantly reduced, and the α-SMA, a smooth muscle-specific marker, expression were also lower than the untreated atherosclerotic rats. Western blot analyses showed that the apocynum can marked increase the p-AMPK but decrease the mTOR protein expression. The apocynum leaf extract also exhibited higher AMPK and lower mTOR mRNA expression of the aorta in the atherosclerotic rats. We believe that the apocynum leaf extract can effectively reduce blood lipid levels in rats with atherosclerosis, delay atherosclerotic progression by inhibiting excessive collagen synthesis and inhibiting smooth muscle cell over-proliferation. The underlying mechanism may be related to the AMPK/mTOR signaling pathway activity. Our results contribute towards validation of the traditional use of apocynum leaf extract in the treatment of atherosclerosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180214
[Lr] Last revision date:180214
[St] Status:In-Process
[do] DOI:10.1691/ph.2017.6703

  10 / 1353 MEDLINE  
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[PMID]: 29438299
[Au] Autor:Mohamed Isa SSP; Ablat A; Mohamad J
[Ad] Address:Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia. sarwaniputri@gmail.com.
[Ti] Title:The Antioxidant and Xanthine Oxidase Inhibitory Activity of Plumeria rubra Flowers.
[So] Source:Molecules;23(2), 2018 Feb 13.
[Is] ISSN:1420-3049
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Linn of the family Apocynaceae is locally known in Malaysia as "Kemboja". It has been used by local traditional medicine practitioners for the treatment of arthritis-related disease. The LCMS/MS analysis of the methanol extract of flowers (PR-ME) showed that it contains 3- -caffeyolquinic acid, 5-caffeoquinic acid, 1,3-dicaffeoquinic acid, chlorogenic acid, citric acid, 3,3-di- -methylellagic acid, kaempferol-3- -glucoside, kaempferol-3-rutinoside, kaempferol, quercetin 3- -α-l-arabinopyranoside, quercetin, quinic acid and rutin. The flower PR-ME contained high amounts of phenol and flavonoid at 184.632 mg GAE/g and 203.2.2 mg QE/g, respectively. It also exhibited the highest DPPH, FRAP, metal chelating, hydrogen peroxide, nitric oxide superoxide radical scavenging activity. Similarly, the XO inhibitory activity in vitro assay possesses the highest inhibition effects at an IC = 23.91 µg/mL. There was no mortality or signs of toxicity in rats at a dose of 4 g/kg body weight. The administration of the flower PR-ME at doses of 400 mg/kg to the rats significantly reduced serum uric acid 43.77%. Similarly, the XO activity in the liver was significantly inhibited by flower PR-ME at doses of 400 mg/kg. These results confirm that the flower PR-ME of contains active phytochemical compounds as detected in LCMS/MS that contribute to the inhibition of XO activity in vitro and in vivo in reducing acid uric level in serum and simultaneously scavenging the free radical to reduce the oxidative stress.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[St] Status:In-Process


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