Database : MEDLINE
Search on : ascitic and fluid [Words]
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[PMID]: 29521663
[Au] Autor:Iliaz R; Ozpolat T; Baran B; Demir K; Kaymakoglu S; Besisik F; Akyuz F
[Ad] Address:Department of Gastroenterology, Istanbul School of Medicine, Istanbul University.
[Ti] Title:Predicting mortality in patients with spontaneous bacterial peritonitis using routine inflammatory and biochemical markers.
[So] Source:Eur J Gastroenterol Hepatol;, 2018 Mar 08.
[Is] ISSN:1473-5687
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVES: Spontaneous bacterial peritonitis (SBP) is a common and high-mortality infectious complication of patients with cirrhosis. New inflammatory markers are associated with morbidity/mortality in various diseases. The aim of our study was to find the 30-day mortality rate of SBP and their predictors. PATIENTS AND METHODS: Seventy patients with cirrhosis complicated with SBP and 55 non-SBP controls were enrolled into the study, and patients were evaluated for mortality rate and its predictors. RESULTS: The 30-day and 3-month mortality rates in the SBP group were 26.1 and 50.7%, respectively. Mortality rates were higher in the SBP group than in the controls. Symptoms at hospital admission and cell counts in ascitic fluid made no difference in predicting 30-day mortality. Patients with SBP with high serum neutrophil counts, high neutrophil-lymphocyte ratio, high C reactive protein (CRP)/albumin ratio, and high model for end-stage liver disease (MELD) score had higher 30-day mortality rates. We determined optimal cutoff values of MELD scores and serum neutrophil counts for predicting 30-day mortality as 20.5 and 6850/mm, respectively. The sensitivity and specificity for the MELD cutoff value were 83.3 and 80.4%, respectively. We also followed up patients for 60 months after SBP; the patients with high inflammatory markers and MELD scores at the time of SBP diagnosis had worse survival compared with the group with lower levels. CONCLUSION: Our results suggest that SBP has high 30-day mortality. MELD scores and inflammatory markers (CRP, CRP albumin ratio, neutrophil-lymphocyte ratio) may be used to predict mortality in patients with SBP.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1097/MEG.0000000000001111

  2 / 15031 MEDLINE  
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[PMID]: 29505476
[Au] Autor:Abdel-Razik A; Eldars W; Elhelaly R; Eldeeb AA; Abdelsalam M; El-Wakeel N; Aboulmagd A
[Ad] Address:Departments of Tropical Medicine.
[Ti] Title:Homocysteine: a new diagnostic marker in spontaneous bacterial peritonitis.
[So] Source:Eur J Gastroenterol Hepatol;, 2018 Mar 02.
[Is] ISSN:1473-5687
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND AND AIMS: The diagnosis of spontaneous bacterial peritonitis (SBP) depends primarily on a polymorphonuclear leukocyte cell count more than 250/mm. This method is invasive, and not diagnostic in all variants of SBP; we aimed to assess serum homocysteine as a precise indicative marker for the diagnosis of all variants of SBP. PATIENTS AND METHODS: A total 323 consecutive ascitic patients were registered in this prospective work. Serum and ascitic fluid of homocysteine were evaluated utilizing an enzyme-linked immunosorbent assay. RESULTS: Participants were classified into a non-SBP group, including 262 participants and 61 patients with SBP. Serum and ascitic homocysteine were considerably elevated in the SBP group than in the non-SBP group (17.94±7.57 vs. 11.75±5.68 µmol/l; P<0.001 and 14.70±5.45 vs. 9.75±4.55 µmol/l; P<0.001). At a cutoff value of 17.79 µmol/l, serum homocysteine had 89.3% specificity and 95.1% sensitivity for distinguishing SBP (area under the curve: 0.932) and, at a cutoff value of 16.1 µmol/l, ascitic homocysteine had 84.4% specificity and 92.7% sensitivity for distinguishing SBP (area under the curve: 0.901). Both were positively correlated with the polymorphonuclear count, C-reactive protein, Child-Pugh score, and Model For End-Stage Liver Disease score as well as negatively correlated with the protein content in the ascitic fluid and estimated glomerular filtration rate. After SBP therapy, there was a marked reduction in serum and ascitic homocysteine levels. CONCLUSION: This study demonstrates that serum and ascitic homocysteine are considerably higher in SBP participants versus non-SBP patients. Serum homocysteine may provide a reliable and noninvasive diagnostic marker for all variants of SBP.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1097/MEG.0000000000001109

  3 / 15031 MEDLINE  
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[PMID]: 29446248
[Au] Autor:Laé M; Bourgoin R; Cornelis F; Klijanienko J
[Ad] Address:Department of Pathology, Institut Curie, 75248 Paris cedex 05, France.
[Ti] Title:Cytological features of small cell carcinoma of the ovary-hypercalcemic type/malignant ovarian rhabdoid tumor in ascitic fluid.
[So] Source:Diagn Cytopathol;46(4):365-366, 2018 Apr.
[Is] ISSN:1097-0339
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1802
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Data-Review
[do] DOI:10.1002/dc.23904

  4 / 15031 MEDLINE  
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[PMID]: 29432847
[Au] Autor:Hassan W; Chitcholtan K; Sykes P; Garrill A
[Ad] Address:School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, 8041, New Zealand. Electronic address: wafaa.hassan@pg.canterbury.ac.nz.
[Ti] Title:Ascitic fluid from advanced ovarian cancer patients compromises the activity of receptor tyrosine kinase inhibitors in 3D cell clusters of ovarian cancer cells.
[So] Source:Cancer Lett;420:168-181, 2018 Apr 28.
[Is] ISSN:1872-7980
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:Ovarian cancer patients in the advanced stages of the disease show clinical ascites, which is associated with a poor prognosis. There is limited understanding of the effect of ascitic fluid on ovarian cancer cells and their response to anticancer drugs. We investigated the antitumour effects of EGFR/Her-2 (canertinib) and c-Met (PHA665752) inhibitors in a 3D cell model of three ovarian cancer lines. Single and combined inhibitor treatments affected cell growth of OVCAR-5 and SKOV-3 cell lines but not OV-90 cell line. Growth reduction was correlated with the down expression of PCNA, EGFR, HER-2, c-MET, ERK and AKT and their phosphorylation status in cells in growth factor supplemented media. However, these effects were not re-producible in OVCAR-5 and SKOV-3 cell lines when they were exposed to ascitic fluid obtained from three ovarian cancer patients. Serum albumin and protein components in the ascitic fluids may reduce the cellular uptake of the inhibitors.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[St] Status:In-Data-Review

  5 / 15031 MEDLINE  
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[PMID]: 29471689
[Au] Autor:Baintner K
[Ad] Address:1 Faculty of Agricultural and Environmental Sciences, Institute of Physiology, Biochemistry and Animal Health, University of Kaposvár , Kaposvár, Hungary.
[Ti] Title:Mediation of inflammatory ascites formation induced by macromolecules in mice.
[So] Source:Acta Microbiol Immunol Hung;:1-12, 2018 Feb 23.
[Is] ISSN:1217-8950
[Cp] Country of publication:Hungary
[La] Language:eng
[Ab] Abstract:The first 60-min phase of inflammatory ascites formation was studied by intraperitoneally (i.p.) administered macromolecular inducers: yeast cell wall zymosan binds to specific macrophage receptors, polyethyleneimine (PEI) and concanavalin A (ConA), produces non-covalent cross-links on the surface of various cells, while λ-carrageenan may function as a contact activator. Depletion of peritoneal macrophages was performed by overnight pretreatment with diphtheria toxin in transgenic mice, resulting in a significant (p < 0.01) decrease in the induced formation of ascitic fluid. It was shown that induced ascites is mediated partly (PEI, ConA, and carrageenan) or completely (zymosan) by peritoneal macrophages. Inhibition of prostanoid synthesis with indomethacine or of the kallikrein/bradykinin system with aprotinin also produced a significant (p < 0.01) but incomplete inhibition. A slight additivity occurred between the different inhibitory effects. In another series of experiments, the i.p. administration of bradykinin (without a macromolecular inducer) also produced marked ascites, which was not affected by macrophage depletion. The origin of the macrophage-independent part of the induced ascites is best explained by the deformation of the mesothelial cell surface, resulting in signal transfer to the underlying endothelium and the passage of ascitic fluid in the opposite direction. The soluble mediators are represented by prostanoids, bradykinin and other, unidentified agonists.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180223
[Lr] Last revision date:180223
[St] Status:Publisher
[do] DOI:10.1556/030.65.2018.004

  6 / 15031 MEDLINE  
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[PMID]: 28468865
[Au] Autor:Husain H; Nykin D; Bui N; Quan D; Gomez G; Woodward B; Venkatapathy S; Duttagupta R; Fung E; Lippman SM; Kurzrock R
[Ad] Address:Division of Hematology and Oncology, University of California San Diego, San Diego, California. hhusain@ucsd.edu.
[Ti] Title:Cell-Free DNA from Ascites and Pleural Effusions: Molecular Insights into Genomic Aberrations and Disease Biology.
[So] Source:Mol Cancer Ther;16(5):948-955, 2017 May.
[Is] ISSN:1538-8514
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Collection of cell-free DNA (cfDNA) from the blood of individuals with cancer has permitted noninvasive tumor genome analysis. Detection and characterization of cfDNA in ascites and pleural effusions have not yet been reported. Herein, we analyzed cfDNA in the ascites and pleural effusions from six individuals with metastatic cancer. In all cases, cfDNA copy number variations (CNV) were discovered within the effusate. One individual had a relevant alteration with a high copy amplification in in a never smoker with lung cancer, who showed only and amplification in a prior tissue biopsy. Another subject with metastatic breast cancer had cytology-positive ascites and an activating mutation identified in the tissue, blood, and ascites collectively. This individual had tumor regression after the administration of the mTOR inhibitor everolimus and had evidence of chromotripsis from chromosomal rearrangements noted in the cell-free ascitic fluid. These results indicate that cfDNA from ascites and pleural effusions may provide additional information not detected with tumor and plasma cell-free DNA molecular characterization, and a context for important insights into tumor biology and clonal dynamic change within primary tumor and metastatic deposits. .
[Mh] MeSH terms primary: Ascites/genetics
Cell-Free Nucleic Acids/genetics
Genome, Human/genetics
Neoplasms/genetics
[Mh] MeSH terms secundary: Adult
Aged
Aged, 80 and over
Ascites/blood
Cell Line, Tumor
Cell-Free Nucleic Acids/blood
Class I Phosphatidylinositol 3-Kinases/genetics
Cyclin-Dependent Kinase 4/genetics
DNA Copy Number Variations/genetics
Female
Humans
Male
Middle Aged
Mutation
Neoplasms/blood
Neoplasms/classification
Neoplasms/pathology
Pleural Effusion/genetics
Proto-Oncogene Proteins c-mdm2/genetics
Receptor, Epidermal Growth Factor/genetics
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Cell-Free Nucleic Acids); EC 2.3.2.27 (MDM2 protein, human); EC 2.3.2.27 (Proto-Oncogene Proteins c-mdm2); EC 2.7.1.137 (Class I Phosphatidylinositol 3-Kinases); EC 2.7.1.137 (PIK3CA protein, human); EC 2.7.10.1 (EGFR protein, human); EC 2.7.10.1 (Receptor, Epidermal Growth Factor); EC 2.7.11.22 (CDK4 protein, human); EC 2.7.11.22 (Cyclin-Dependent Kinase 4)
[Em] Entry month:1802
[Cu] Class update date: 180221
[Lr] Last revision date:180221
[Js] Journal subset:IM
[Da] Date of entry for processing:170505
[St] Status:MEDLINE
[do] DOI:10.1158/1535-7163.MCT-16-0436

  7 / 15031 MEDLINE  
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[PMID]: 29239296
[Au] Autor:Avendaño-Perez L; Espinola-Zavaleta N
[Ad] Address:Laboratory of Echocardiography and Non-invasive Hemodynamics,Instituto Nacional de Cardiología Ignacio Chavez,Mexico City,Mexico.
[Ti] Title:Ascites in an uncorrected tetralogy of Fallot with pulmonary valve absence in an adult patient.
[So] Source:Cardiol Young;28(3):490-493, 2018 Mar.
[Is] ISSN:1467-1107
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:This is a case of a 37-year-old woman with uncorrected tetralogy of Fallot with the absence of pulmonary valve and history of heart murmur in childhood who did not have a medical approach. At 29 years of age she started with dyspnoea that in the last 7 months progressed to be of small effort and also referred increase of the abdominal perimeter.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[St] Status:In-Process
[do] DOI:10.1017/S1047951117002451

  8 / 15031 MEDLINE  
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[PMID]: 29342108
[Au] Autor:Wefers C; Duiveman-de Boer T; Zusterzeel PLM; Massuger LFAG; Fuchs D; Torensma R; Wheelock CE; de Vries IJM
[Ad] Address:Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Geert Grooteplein Zuid 28, 6525 GA Nijmegen, The Netherlands. christina.wefers@radboudumc.nl.
[Ti] Title:Different Lipid Regulation in Ovarian Cancer: Inhibition of the Immune System.
[So] Source:Int J Mol Sci;19(1), 2018 Jan 17.
[Is] ISSN:1422-0067
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Lipid metabolism is altered in several cancer settings leading to different ratios of intermediates. Ovarian cancer is the most lethal gynecological malignancy. Cancer cells disperse in the abdominal space and ascites occurs. T cells obtained from ascites are unable to proliferate after an antigenic stimulus. The proliferation of ascites-derived T cells can be restored after culturing the cells for ten days in normal culture medium. No pathway aberrancies were detected. The acellular fraction of ascites can inhibit the proliferation of autologous as well as allogeneic peripheral blood lymphocytes, indicating the presence of soluble factors that interfere with T cell functionality. Therefore, we analyzed 109 lipid mediators and found differentially regulated lipids in suppressive ascitic fluid compared to normal abdominal fluid. Our study indicates the presence of lipid intermediates in ascites of ovarian cancer patients, which coincidences with T cell dysfunctionality. Since the immune system in the abdominal cavity is compromised, this may explain the high seeding efficiency of disseminated tumor cells. Further research is needed to fully understand the correlation between the various lipids and T cell proliferation, which could lead to new treatment options.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[St] Status:In-Process

  9 / 15031 MEDLINE  
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[PMID]: 29429592
[Au] Autor:Li Y; Wu T; Wang Y; Yang L; Hu C; Chen L; Wu S
[Ad] Address:Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
[Ti] Title:γ-Glutamyl cyclotransferase contributes to tumor progression in high grade serous ovarian cancer by regulating epithelial-mesenchymal transition via activating PI3K/AKT/mTOR pathway.
[So] Source:Gynecol Oncol;, 2018 Feb 08.
[Is] ISSN:1095-6859
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: High grade serous ovarian cancer (HGSC) remains one of the most lethal malignancies in females. We previously reported that γ-glutamyl cyclotransferase (GGCT) was significantly upregulated in serous ovarian cancer. The current study was aimed to explore the function and underlying mechanism of GGCT in HGSC. METHODS: GGCT expression was assessed by immunohistochemistry in 128 HGSC patients. Stable cell lines with GGCT gene overexpression or knockdown were established to investigate the function of GGCT in HGSC in vitro and in vivo. RESULTS: GGCT is highly upregulated in HGSC tissues and associated with FIGO stage, lymph node metastasis and ascitic fluid volume. High expression of GGCT is associated with poor survival in HGSC patients. The Harrell's c-indexes of the prognostic models for overall survival and progression-free survival prediction were 0.758 and 0.726, respectively. GGCT knockdown suppresses proliferation, clone formation, migration, and invasion of tumor cells in vitro while forced GGCT overexpression presents opposite results. Furthermore, GGCT silencing inhibits tumor growth and spread in vivo. Epithelial-mesenchymal transition (EMT) and PI3K/AKT/mTOR signaling pathway are suppressed in GGCT silenced cells and enhanced in GGCT overexpressed cells. Inactivation of PI3K/AKT/mTOR signaling pathway in GGCT overexpressed cells induces EMT inhibition. CONCLUSIONS: Our data reveals an important role of GGCT in regulating EMT and progression of HGSC, providing a valuable prognostic marker and potential target for treatment of HGSC patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180212
[Lr] Last revision date:180212
[St] Status:Publisher

  10 / 15031 MEDLINE  
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[PMID]: 29427281
[Au] Autor:Nunes G; Fonseca C; Barosa R; Patita M; Gomes A; Botas J; Coelho H; Brito MJ; Fonseca J
[Ad] Address:Gastroenterology Department, Hospital Garcia de Orta, Av. Torrado da Silva, 2805-267, Almada, Portugal. goncalo.n@hotmail.com.
[Ti] Title:Idiopathic chylous ascites in a patient with HIV infection: response to total parenteral nutrition and octreotide therapy.
[So] Source:Clin J Gastroenterol;, 2018 Feb 09.
[Is] ISSN:1865-7265
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:The authors describe a 47-year-old man infected with human immunodeficiency virus admitted for ascites and weight loss. Ascitic fluid analysis revealed chylous ascites (triglycerides 444 mg/dl) with negative microbiological tests. Neoplasia, cardiac disease and liver cirrhosis were excluded after an extensive diagnostic workout. Exploratory laparotomy with tissue sampling did not clarify ascites etiology. During hospital admission, patient status gradually deteriorated, severe malnutrition developed and ascites became refractory to diuretics. Total parenteral nutrition and octreotide therapy were started and maintained for 3 weeks with ascites resolution and no relapse after oral diet resumption. Chylous ascites is a rare entity with several causes that compromise intra-abdominal lymphatic drainage. This case illustrates the difficulty in establishing etiology in some patients and the effectiveness of total parenteral nutrition plus octreotide therapy in idiopathic chylous ascites in HIV-infected patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180210
[Lr] Last revision date:180210
[St] Status:Publisher
[do] DOI:10.1007/s12328-018-0832-x


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