Database : MEDLINE
Search on : asphyxia and neonatorum [Words]
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[PMID]: 29341561
[Au] Autor:Dobrosavljevic A; Martic J; Rakic S; Pazin V; Jankovic-Raznatovic S; Sreckovic S; Dobrosavljevic B
[Ti] Title:Massive fetomaternal hemorrhage as a cause of severe fetal anemia.
[So] Source:Vojnosanit Pregl;73(11):1068-71, 2016 Nov.
[Is] ISSN:0042-8450
[Cp] Country of publication:Serbia
[La] Language:eng
[Ab] Abstract:Introduction: Fetomaternal hemorrhage (FMH) is a transfu-sion of fetal blood into the maternal circulation. A volume of transfused fetal blood required to cause severe, life-threatening fetal anemia, is not clearly defined. Some authors suggest vol-umes of 80 mL and 150 mL as a threshold which defines mas-sive FMH. Therefore, a rate of massive FMH is 1 : 1,000 and 1 : 5,000 births, respectively. Fetal and neonatal anemia is one of the most serious complications of the FMH. Clinical manifesta-tions of FMH are nonspecific, and mostly it presented as re-duced fetal movements and changes in cardiotocography (CTG). The standard for diagnosing FMH is Kleihaurer-Betke test. Case report: A 34-year-old gravida (G) 1, para (P) 1 was hospitalized due to uterine contractions at 39 weeks of gesta-tion. CTG monitoring revealed sinusoidal fetal heart rate and clinical examination showed complete cervical dilatation. Im-mediately after admission, the women delivered vaginally. Ap-gar scores were 1 and 2 at the first and fifth minute, respec-tively. Immediately baby was intubated and mechanical ventila-tion started. Initial analysis revealed pronounced acidosis and severe anemia. The patient received intravenous fluid therapy with sodium-bicarbonate as well as red cell transfusion. With all measures, the condition of the baby improved with normaliza-tion of hemoglobin level and blood pH. Kleihaurer-Betke test revealed the presence of fetal red cells in maternal circulation, equivalent to 531 mL blood loss. The level of maternal fetal hemoglobin (HbF) and elevated alpha fetoprotein also con-firmed the diagnosis of massive FMH. Conclusion: For the successful diagnosis and management of FMH direct commu-nication between the obstetrician and the pediatrician is neces-sary as presented in this report.
[Mh] MeSH terms primary: Anemia, Neonatal/etiology
Fetomaternal Transfusion/complications
Placental Circulation
[Mh] MeSH terms secundary: Adult
Anemia, Neonatal/blood
Anemia, Neonatal/diagnosis
Anemia, Neonatal/therapy
Asphyxia Neonatorum/etiology
Biomarkers/blood
Cardiotocography
Erythrocyte Transfusion
Female
Fetal Hemoglobin/metabolism
Fetomaternal Transfusion/blood
Fetomaternal Transfusion/diagnosis
Fetomaternal Transfusion/therapy
Fluid Therapy
Humans
Live Birth
Pregnancy
Treatment Outcome
alpha-Fetoproteins/metabolism
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (AFP protein, human); 0 (Biomarkers); 0 (alpha-Fetoproteins); 9034-63-3 (Fetal Hemoglobin)
[Em] Entry month:1802
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[Js] Journal subset:IM
[Da] Date of entry for processing:180118
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150605130D

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[PMID]: 28448965
[Au] Autor:Berger HR; Brekke E; Widerøe M; Morken TS
[Ad] Address:Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
[Ti] Title:Neuroprotective Treatments after Perinatal Hypoxic-Ischemic Brain Injury Evaluated with Magnetic Resonance Spectroscopy.
[So] Source:Dev Neurosci;39(1-4):36-48, 2017.
[Is] ISSN:1421-9859
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Perinatal hypoxic-ischemic brain injury is a major health problem. Adjuvant treatments that improve the neuroprotective effect of the current treatment, therapeutic hypothermia, are urgently needed. The growing knowledge about the complex pathophysiology of hypoxia-ischemia (HI) has led to the discovery of several important targets for neuroprotection. Early interventions should focus on the preservation of energy metabolism, the reduction of glutamate excitotoxicity and oxidative stress, the maintenance of calcium homeostasis, and the prevention of apoptosis. Delayed interventions should promote injury repair. The multiple metabolic changes following HI as well as the metabolic effects of potential treatments can be observed noninvasively by magnetic resonance spectroscopy (MRS). This mini-review provides an overview of the neuroprotective pharmacological agents that have been evaluated with 1H/31P/13C MRS. A better understanding of how these agents influence cerebral metabolism and the use of relevant translational MRS biomarkers can guide future clinical trials.
[Mh] MeSH terms primary: Hypoxia-Ischemia, Brain/diagnostic imaging
Magnetic Resonance Spectroscopy/methods
Neuroprotective Agents/therapeutic use
[Mh] MeSH terms secundary: Animals
Asphyxia Neonatorum/diagnostic imaging
Asphyxia Neonatorum/therapy
Brain/drug effects
Humans
Infant, Newborn
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Neuroprotective Agents)
[Em] Entry month:1802
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[Js] Journal subset:IM
[Da] Date of entry for processing:170428
[St] Status:MEDLINE
[do] DOI:10.1159/000472709

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[PMID]: 29351779
[Au] Autor:Lindroos L; Elfvin A; Ladfors L; Wennerholm UB
[Ad] Address:Department of Obstetrics and Gynecology, Institute of Clinical Sciences at Sahlgrenska Academy, Gothenburg University, Diagnosvägen 15, 416 85, Gothenburg, Sweden. linnea.lindroos@vgregion.se.
[Ti] Title:The effect of twin-to-twin delivery time intervals on neonatal outcome for second twins.
[So] Source:BMC Pregnancy Childbirth;18(1):36, 2018 01 19.
[Is] ISSN:1471-2393
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: The objective was to examine the effect of twin-to-twin delivery intervals on neonatal outcome for second twins. METHODS: This was a retrospective, hospital-based study, performed at a university teaching hospital in Western Sweden. Twin deliveries between 2008 and 2014 at ≥32 + 0 weeks of gestation, where the first twin was delivered vaginally, were included. Primary outcome was a composite outcome of metabolic acidosis, Apgar < 4 at 5 min or peri/neonatal mortality in the second twin. Secondary outcome was a composite outcome of neonatal morbidity. RESULTS: A total of 527 twin deliveries were included. The median twin-to-twin delivery interval time was 19 min (range 2-399 min) and 68% of all second twins were delivered within 30 min. Primary outcome occurred in 2.6% of the second twins. Median twin-to-twin delivery interval was 34 min (8-78 min) for the second twin with a primary outcome, and 19 min (2-399 min) for the second twin with no primary outcome (p = 0.028). Second twins delivered within a twin-to-twin interval of 0-30 min had a higher pH in umbilical artery blood gas than those delivered after 30 min (pH 7.23 and pH 7.20, p <  0.0001). Secondary outcome was not associated with twin-to-twin delivery interval time. The combined vaginal-cesarean delivery rate was 6.6% (n = 35) and the rate was higher with twin-to-twin delivery interval >  30 min (p <  0.0001). CONCLUSIONS: An association, but not necessarily a causality, between twin-to-twin delivery interval and primary outcome was seen. An upper time limit on twin-to-twin delivery time intervals may be justified. However, the optimal time interval needs further studies.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1801
[Cu] Class update date: 180212
[Lr] Last revision date:180212
[St] Status:In-Process
[do] DOI:10.1186/s12884-018-1668-6

  4 / 6131 MEDLINE  
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[PMID]: 29246356
[Au] Autor:Weeke LC; Groenendaal F; Mudigonda K; Blennow M; Lequin MH; Meiners LC; van Haastert IC; Benders MJ; Hallberg B; de Vries LS
[Ad] Address:Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, The Netherlands.
[Ti] Title:A Novel Magnetic Resonance Imaging Score Predicts Neurodevelopmental Outcome After Perinatal Asphyxia and Therapeutic Hypothermia.
[So] Source:J Pediatr;192:33-40.e2, 2018 Jan.
[Is] ISSN:1097-6833
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To assess the predictive value of a novel magnetic resonance imaging (MRI) score, which includes diffusion-weighted imaging as well as assessment of the deep grey matter, white matter, and cerebellum, for neurodevelopmental outcome at 2 years and school age among term infants with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia. STUDY DESIGN: This retrospective cohort study (cohort 1, The Netherlands 2008-2014; cohort 2, Sweden 2007-2012) including infants born at >36 weeks of gestational age treated with therapeutic hypothermia who had an MRI in the first weeks of life. The MRI score consisted of 3 subscores: deep grey matter, white matter/cortex, and cerebellum. Primary adverse outcome was defined as death, cerebral palsy, Bayley Scales of Infant and Toddler Development, third edition, motor or cognitive composite scores at 2 years of <85, or IQ at school age of <85. RESULTS: In cohort 1 (n = 97) and cohort 2 (n = 76) the grey matter subscore was an independent predictor of adverse outcome at 2 years (cohort 1, OR, 1.6; 95% CI, 1.3-1.9; cohort 2, OR, 1.4; 95% CI, 1.2-1.6), and school age (cohort 1, OR, 1.3; 95% CI, 1.2-1.5; cohort 2, OR, 1.3; 95% CI, 1.1-1.6). The white matter and cerebellum subscore did not add to the predictive value. The positive predictive value, negative predictive value, and area under the curve for the grey matter subscore were all >0.83 in both cohorts, whereas the specificity was >0.91 with variable sensitivity. CONCLUSION: A novel MRI score, which includes diffusion-weighted imaging and assesses all brain areas of importance in infants with therapeutic hypothermia after perinatal asphyxia, has predictive value for outcome at 2 years of age and at school age, for which the grey matter subscore can be used independently.
[Mh] MeSH terms primary: Asphyxia Neonatorum/diagnostic imaging
Cerebral Palsy/etiology
Developmental Disabilities/etiology
Diffusion Magnetic Resonance Imaging
Hypothermia, Induced
Hypoxia-Ischemia, Brain/diagnostic imaging
Severity of Illness Index
[Mh] MeSH terms secundary: Asphyxia Neonatorum/complications
Asphyxia Neonatorum/mortality
Asphyxia Neonatorum/therapy
Brain/diagnostic imaging
Cerebral Palsy/diagnosis
Child
Child, Preschool
Decision Support Techniques
Developmental Disabilities/diagnosis
Female
Follow-Up Studies
Humans
Hypoxia-Ischemia, Brain/complications
Hypoxia-Ischemia, Brain/mortality
Hypoxia-Ischemia, Brain/therapy
Infant, Newborn
Logistic Models
Male
Predictive Value of Tests
Retrospective Studies
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180104
[Lr] Last revision date:180104
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:171217
[St] Status:MEDLINE

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[PMID]: 28961316
[Au] Autor:Liu X; Jary S; Cowan F; Thoresen M
[Ad] Address:Neonatal Neuroscience, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
[Ti] Title:Reduced infancy and childhood epilepsy following hypothermia-treated neonatal encephalopathy.
[So] Source:Epilepsia;58(11):1902-1911, 2017 Nov.
[Is] ISSN:1528-1167
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To investigate what proportion of a regional cohort of cooled infants with neonatal encephalopathy develop epilepsy (determined by the International League Against Epilepsy [ILAE] definition and the number of antiepileptic drugs [AEDs]) up to 8 years of age. METHODS: From 2006-2013, 151 infants with perinatal asphyxia underwent 72 h cooling. Clinical and amplitude-integrated electroencepalography (aEEG) with single-channel EEG-verified neonatal seizures were treated with AEDs. Brain magnetic resonance imaging (MRI) was assessed using a 0-11 severity score. Postneonatal seizures, epilepsy rates, and AED treatments were documented. One hundred thirty-four survivors were assessed at 18-24 months; adverse outcome was defined as death or Bayley III composite Cognition/Language or Motor scores <85 and/or severe cerebral palsy or severely reduced vision/hearing. Epilepsy rates in 103 children age 4-8 years were also documented. RESULTS: aEEG confirmed seizures occurred precooling in 77 (57%) 151 of neonates; 48% had seizures during and/or after cooling and received AEDs. Only one infant was discharged on AEDs. At 18-24 months, one third of infants had an adverse outcome including 11% mortality. At 2 years, 8 (6%) infants had an epilepsy diagnosis (ILAE definition), of whom 3 (2%) received AEDs. Of the 103 4- to 8-year-olds, 14 (13%) had developed epilepsy, with 7 (7%) receiving AEDs. Infants/children on AEDs had higher MRI scores than those not on AEDs (median [interquartile range] 9 [8-11] vs. 2 [0-4]) and poorer outcomes. Nine (64%) of 14 children with epilepsy had cerebral palsy compared to 13 (11%) of 120 without epilepsy, and 10 (71%) of 14 children with epilepsy had adverse outcomes versus 23 (19%) of 120 survivors without epilepsy. The number of different AEDs given to control neonatal seizures, aEEG severity precooling, and MRI scores predicted childhood epilepsy. SIGNIFICANCE: We report, in a regional cohort of infants cooled for perinatal asphyxia, 6% with epilepsy at 2 years (2% on AEDs) increasing to 13% (7% on AEDs) at early school age. These AED rates are much lower than those reported in the cooling trials, even with adjusting for our cohort's milder asphyxia. Long-term follow-up is needed to document final epilepsy rates.
[Mh] MeSH terms primary: Asphyxia Neonatorum/therapy
Brain Diseases/therapy
Epilepsy/therapy
Hypothermia, Induced/trends
[Mh] MeSH terms secundary: Anticonvulsants/therapeutic use
Asphyxia Neonatorum/diagnostic imaging
Asphyxia Neonatorum/physiopathology
Brain Diseases/diagnostic imaging
Brain Diseases/physiopathology
Child
Child, Preschool
Electroencephalography/trends
Epilepsy/diagnostic imaging
Epilepsy/physiopathology
Female
Follow-Up Studies
Humans
Hypothermia, Induced/methods
Infant
Male
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Anticonvulsants)
[Em] Entry month:1711
[Cu] Class update date: 171109
[Lr] Last revision date:171109
[Js] Journal subset:IM
[Da] Date of entry for processing:170930
[St] Status:MEDLINE
[do] DOI:10.1111/epi.13914

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[PMID]: 28931055
[Au] Autor:Kelen D; Andorka C; Szabó M; Alafuzoff A; Kaila K; Summanen M
[Ad] Address:First Department of Pediatrics, Semmelweis University, Budapest, Hungary.
[Ti] Title:Serum copeptin and neuron specific enolase are markers of neonatal distress and long-term neurodevelopmental outcome.
[So] Source:PLoS One;12(9):e0184593, 2017.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The objective of this study was to evaluate the early changes in serial serum levels of copeptin and neuron-specific enolase (NSE) in neonates diagnosed with birth asphyxia, and to determine whether these biomarkers measured in the first 168 hours after birth are predictive of long-term neurodevelopmental outcome. Copeptin and NSE levels were measured from serum samples collected 6, 12, 24, 48, 72, and 168 hours after birth from 75 term neonates diagnosed with hypoxic-ischemic encephalopathy (HIE) and treated with therapeutic hypothermia for 72 hours. In addition, serum copeptin levels after birth were measured from 10 HIE diagnosed neonates, who were randomized to the normothermic arm of the TOBY cohort. All neonates underwent neurodevelopmental assessment using the Bayley Scales of Infant and Toddler Development-II at two years of age. Copeptin levels were highest at 6 hours after birth and steadily decreased, whereas the highest NSE levels were measured at 24 hours after birth. The biomarker levels correlated with blood-gas parameters (base excess, pH and lactate) at 6 and 12 hours after birth. Copeptin and NSE levels in the early postnatal period were significantly higher in neonates with poor outcome compared to those with favorable outcome at two years of age. Furthermore, in the TOBY cohort, copeptin levels were significantly lower in hypothermic compared to normothermic neonates. To conclude, copeptin and NSE measured in the early postnatal period are potential prognostic biomarkers of long-term neurodevelopmental outcome in term neonates diagnosed with HIE and treated with therapeutic hypothermia.
[Mh] MeSH terms primary: Asphyxia Neonatorum/blood
Biomarkers/blood
Glycopeptides/blood
Hypothermia, Induced
Hypoxia-Ischemia, Brain/blood
Phosphopyruvate Hydratase/blood
[Mh] MeSH terms secundary: Asphyxia Neonatorum/therapy
Child, Preschool
Female
Gestational Age
Humans
Hypoxia-Ischemia, Brain/therapy
Immunologic Tests
Infant
Infant, Newborn
Male
[Pt] Publication type:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Name of substance:0 (Biomarkers); 0 (Glycopeptides); 0 (copeptins); EC 4.2.1.11 (Phosphopyruvate Hydratase)
[Em] Entry month:1710
[Cu] Class update date: 171017
[Lr] Last revision date:171017
[Js] Journal subset:IM
[Da] Date of entry for processing:170921
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184593

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[PMID]: 28912163
[Au] Autor:Pejovic NJ; Trevisanuto D; Lubulwa C; Myrnerts Höök S; Cavallin F; Byamugisha J; Nankunda J; Tylleskär T
[Ad] Address:Centre for International Health, Universitetet i Bergen, Bergen, Norway.
[Ti] Title:Neonatal resuscitation using a laryngeal mask airway: a randomised trial in Uganda.
[So] Source:Arch Dis Child;, 2017 Sep 14.
[Is] ISSN:1468-2044
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Mortality rates from birth asphyxia in low-income countries remain high. Face mask ventilation (FMV) performed by midwives is the usual method of resuscitating neonates in such settings but may not always be effective. The i-gel is a cuffless laryngeal mask airway (LMA) that could enhance neonatal resuscitation performance. We aimed to compare LMA and face mask (FM) during neonatal resuscitation in a low-resource setting. SETTING: Mulago National Referral Hospital, Kampala, Uganda. DESIGN: This prospective randomised clinical trial was conducted at the labour ward operating theatre. After a brief training on LMA and FM use, infants with a birth weight >2000 g and requiring positive pressure ventilation at birth were randomised to resuscitation by LMA or FM. Resuscitations were video recorded. MAIN OUTCOME MEASURES: Time to spontaneous breathing. RESULTS: Forty-nine (24 in the LMA and 25 in the FM arm) out of 50 enrolled patients were analysed. Baseline characteristics were comparable between the two arms. Time to spontaneous breathing was shorter in LMA arm than in FM arm (mean 153 s (SD±59) vs 216 s (SD±92)). All resuscitations were effective in LMA arm, whereas 11 patients receiving FM were converted to LMA because response to FMV was unsatisfactory. There were no adverse effects. CONCLUSION: A cuffless LMA was more effective than FM in reducing time to spontaneous breathing. LMA seems to be safe and effective in clinical practice after a short training programme. Its potential benefits on long-term outcomes need to be assessed in a larger trial. CLINICAL TRIAL REGISTRY: This trial was registered in https://clinicaltrials.gov, with registration number NCT02042118.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170915
[Lr] Last revision date:170915
[St] Status:Publisher

  8 / 6131 MEDLINE  
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[PMID]: 28671322
[Au] Autor:Pu Q; Li P; Jiang H; Wang H; Zhou Q; Liu J; Zhong W; Huang H
[Ad] Address:Department of Ophthalmology, Jiaxing Maternal and Child health care Hospital, Jiaxing, Zhejiang, China.
[Ti] Title:Factors related to retinal haemorrhage in infants born at high risk.
[So] Source:Acta Ophthalmol;95(6):e477-e480, 2017 Sep.
[Is] ISSN:1755-3768
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:PURPOSE: This study aims to determine risk factors for retinal haemorrhage (RH) in high-risk infants. METHODS: A total of 3123 cases with high-risk pregnancy and/or neonatal asphyxia 72 hr after delivery were enrolled into this study. Fundus examinations were performed on newborns utilizing a wide-angle imaging system (RetCam III). Retinal haemorrhage (RH) was classified into three grades. Maternal, obstetric and neonatal parameters from high-risk infants with RH were compared with parameters from infants without RH. RESULTS: Retinal haemorrhage (RH) was found in 550 (18%) of 3123 high-risk infants. Retinal haemorrhage (RH) was classified as grade I (39%), grade II (24%) and grade III (37%). Monocular RH occurred in 37% of cases, while the remaining cases were binocular. Moreover, six cases had vitreous haemorrhage. The following parameters correlated (p < 0.05) with RH in this study: delivery mode (χ  = 469), gestational age (χ  = 35), birth weight (χ  = 18), asphyxia (χ  = 73), scalp hematoma (χ  = 55), maternal age (χ  = 8.9), precipitate labour (χ  = 120) and delivery times (χ  = 6.1). Logistic regression analysis indicated that delivery mode and asphyxia were risk factors for RH in high-risk infants, with odds ratios of 0.827 and 2.5, respectively. Gender, intracranial haemorrhage and foetal distress were not correlated with RH in high-risk infants. CONCLUSION: The incidence of RH in high-risk infants was 18%, and delivery mode, and neonatal asphyxia were major risk factors for RH in high-risk infants.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170829
[Lr] Last revision date:170829
[St] Status:In-Process
[do] DOI:10.1111/aos.13515

  9 / 6131 MEDLINE  
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[PMID]: 28570867
[Au] Autor:Nevalainen P; Marchi V; Metsäranta M; Lönnqvist T; Toiviainen-Salo S; Vanhatalo S; Lauronen L
[Ad] Address:Department of Clinical Neurophysiology, Children's Hospital, HUS Medical, Imaging Center, University of Helsinki and Helsinki University Hospital (HUH), Helsinki, Finland. Electronic address: paivi.nevalainen@hus.fi.
[Ti] Title:Evoked potentials recorded during routine EEG predict outcome after perinatal asphyxia.
[So] Source:Clin Neurophysiol;128(7):1337-1343, 2017 Jul.
[Is] ISSN:1872-8952
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To evaluate the added value of somatosensory (SEPs) and visual evoked potentials (VEPs) recorded simultaneously with routine EEG in early outcome prediction of newborns with hypoxic-ischemic encephalopathy under modern intensive care. METHODS: We simultaneously recorded multichannel EEG, median nerve SEPs, and flash VEPs during the first few postnatal days in 50 term newborns with hypoxic-ischemic encephalopathy. EEG background was scored into five grades and the worst two grades were considered to indicate poor cerebral recovery. Evoked potentials were classified as absent or present. Clinical outcome was determined from the medical records at a median age of 21months. Unfavorable outcome included cerebral palsy, severe mental retardation, severe epilepsy, or death. RESULTS: The accuracy of outcome prediction was 98% with SEPs compared to 90% with EEG. EEG alone always predicted unfavorable outcome when it was inactive (n=9), and favorable outcome when it was normal or only mildly abnormal (n=17). However, newborns with moderate or severe EEG background abnormality could have either favorable or unfavorable outcome, which was correctly predicted by SEP in all but one newborn (accuracy in this subgroup 96%). Absent VEPs were always associated with an inactive EEG, and an unfavorable outcome. However, presence of VEPs did not guarantee a favorable outcome. CONCLUSIONS: SEPs accurately predict clinical outcomes in newborns with hypoxic-ischemic encephalopathy and improve the EEG-based prediction particularly in those newborns with severely or moderately abnormal EEG findings. SIGNIFICANCE: SEPs should be added to routine EEG recordings for early bedside assessment of newborns with hypoxic-ischemic encephalopathy.
[Mh] MeSH terms primary: Asphyxia Neonatorum/diagnosis
Asphyxia Neonatorum/physiopathology
Evoked Potentials, Somatosensory/physiology
Evoked Potentials, Visual/physiology
Hypoxia-Ischemia, Brain/diagnosis
Hypoxia-Ischemia, Brain/physiopathology
[Mh] MeSH terms secundary: Female
Humans
Infant, Newborn
Male
Predictive Value of Tests
Retrospective Studies
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170821
[Lr] Last revision date:170821
[Js] Journal subset:IM
[Da] Date of entry for processing:170602
[St] Status:MEDLINE

  10 / 6131 MEDLINE  
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[PMID]: 28527266
[Au] Autor:Torres-Muñoz J; Rojas C; Mendoza-Urbano D; Marín-Cuero D; Orobio S; Echandía C
[Ad] Address:Grupo INSIDE, Departamento de Pediatría, Facultad de Medicina, Universidad del Valle, Cali, Colombia. jtmml@hotmail.com.
[Ti] Title:[Risk factors associated with the development of perinatal asphyxia in neonates at the Hospital Universitario del Valle, Cali, Colombia, 2010-2011].
[So] Source:Biomedica;37(0):51-56, 2017 Apr 01.
[Is] ISSN:0120-4157
[Cp] Country of publication:Colombia
[La] Language:spa
[Ab] Abstract:INTRODUCTION: Perinatal asphyxia is one of the main causes of perinatal mortality and morbidity worldwide and it generates high costs for health systems; however, it has modifiable risk factors. OBJECTIVE: To identify the risk factors associated with the development of perinatal asphyxia in newborns at Hospital Universitario del Valle, Cali, Colombia. MATERIALS AND METHODS: Incident cases and concurrent controls were examined. Cases were defined as newborns with moderate to severe perinatal asphyxia who were older than or equal to 36 weeks of gestational age, needed advanced resuscitation and presented one of the following: early neurological disorders, multi-organ commitment or a sentinel event. The controls were newborns without asphyxia who were born one week apart from the case at the most and had a comparable gestational age. Patients with major congenital malformations and syndromes were excluded. RESULTS: Fifty-six cases and 168 controls were examined. Premature placental abruption (OR=41.09; 95%CI: 4.61-366.56), labor with a prolonged expulsive phase (OR=31.76; 95%CI: 8.33-121.19), lack of oxytocin use (OR=2.57; 95% CI: 1.08 - 6.13) and mothers without a partner (OR=2.56; 95% CI: 1.21-5.41) were risk factors for the development of perinatal asphyxia in the study population. Social difficulties were found in a greater proportion among the mothers of cases. CONCLUSIONS: Proper control and monitoring of labor, development of a thorough partograph, and active searches are recommended to ensure that all pregnant women have adequate prenatal care with the provision of social support to reduce the frequency and negative impact of perinatal asphyxia.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1705
[Cu] Class update date: 170520
[Lr] Last revision date:170520
[St] Status:In-Process
[do] DOI:10.7705/biomedica.v37i1.2844


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