Database : MEDLINE
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[PMID]: 29524795
[Au] Autor:Faraji Aylar M; Jafarnezhadgero AA; Salari Esker F
[Ad] Address:Division of Biomechanics, Department of Mechanical Engineering, Sahand University of Thechnology, Sahand New Town, Tabriz, 51335-1996, Iran. Electronic address: mo_farajiaylar@sut.ac.ir.
[Ti] Title:Sit-to-stand ground reaction force characteristics in blind and sighted female children.
[So] Source:Gait Posture;62:34-40, 2018 Mar 05.
[Is] ISSN:1879-2219
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: The association between visual sensory and sit-to-stand ground reaction force characteristics is not clear. Impulse is the amount of force applied over a period of time. Also, free moment represents the vertical moment applied in the center of pressure (COP). RESEARCH QUESTION: How the ground reaction force components, vertical loading rate, impulses and free moment respond to long and short term restricted visual information? METHODS: Fifteen female children with congenital blindness and 45 healthy girls with no visual impairments participated in this study. The girls with congenital blindness were placed in one group and the 45 girls with no visual impairments were randomly divided into three groups of 15; eyes open, permanently eyes closed, and temporary eyes closed. The participants in the permanently eyes closed group closed their eyes for 20 min before the test, whereas temporary eyes closed group did tests with their eyes closed throughout, and those in the eyes open group kept their eyes open. RESULTS: Congenital blindness was associated with increased vertical loading rate, range of motion of knee and hip in the medio-lateral plane. Also, medio-lateral and vertical ground reaction force impulses. Similar peak negative and positive free moments were observed in three groups. SIGNIFICANCE: In conclusion, the results reveal that sit-to-stand ground reaction force components in blind children may have clinical importance for improvement of balance control of these individuals.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

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[PMID]: 29506498
[Au] Autor:Zhang Y; Chen YG
[Ad] Address:Department of Ophthalmology, Peking University Third Hospital, 49 North Huayuan Road, Haidian District, Beijing, 100191, China.
[Ti] Title:High incidence of rainbow glare after femtosecond laser assisted-LASIK using the upgraded FS200 femtosecond laser.
[So] Source:BMC Ophthalmol;18(1):71, 2018 Mar 05.
[Is] ISSN:1471-2415
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: To compare the incidence of rainbow glare (RG) after femtosecond laser assisted-LASIK (FS-LASIK) using the upgraded FS200 femtosecond laser with different flap cut parameter settings. METHODS: A consecutive series of 129 patients (255 eyes) who underwent FS-LASIK for correcting myopia and/or astigmatism using upgraded WaveLight FS200 femtosecond laser with the original settings was included in group A. Another consecutive series of 129 patients (255 eyes) who underwent FS-LASIK using upgraded WaveLight FS200 femtosecond laser with flap cut parameter settings changed (decreased pulse energy, spot and line separation) was included in group B. The incidence and fading time of RG, confocal microscopic image and postoperative clinical results were compared between the two groups. RESULTS: There were no differences between the two groups in age, baseline refraction, excimer laser ablation depth, postoperative uncorrected visual acuity and refraction. The incidence rate of RG in group A (35/255, 13.73%) was significantly higher than that in group B (4/255, 1.57%) (P < 0.05). The median fading time was 3 months in group A and 1 month in group B (P > 0.05).The confocal microscopic images showed wider laser spot spacing in group A than group B. The incidence of RG was significantly correlated with age and grouping (P < 0.05). CONCLUSIONS: The upgraded FS200 femtosecond laser with original flap cut parameter settings could increase the incidence of RG. The narrower grating size and lower pulse energy could ameliorate this side effect.
[Mh] MeSH terms primary: Astigmatism/surgery
Glare
Keratomileusis, Laser In Situ/methods
Lasers, Excimer/adverse effects
Myopia/surgery
Vision Disorders/epidemiology
[Mh] MeSH terms secundary: Adult
Humans
Incidence
Keratomileusis, Laser In Situ/instrumentation
Microscopy, Confocal
Refraction, Ocular/physiology
Retrospective Studies
Surgical Flaps
Tomography, Optical Coherence
Vision Disorders/physiopathology
Visual Acuity/physiology
[Pt] Publication type:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[Js] Journal subset:IM
[Da] Date of entry for processing:180307
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0734-1

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[PMID]: 29447852
[Au] Autor:Kamijo M; Kawamura M; Fukamachi S
[Ad] Address:Department of Chemical and Biological Sciences, Japan Women's University, Mejirodai 2-8-1, Bunkyo-ku, Tokyo 112-8681, Japan.
[Ti] Title:Loss of red opsin genes relaxes sexual isolation between skin-colour variants of medaka.
[So] Source:Behav Processes;150:25-28, 2018 Feb 12.
[Is] ISSN:1872-8308
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Colour vision is often essential for animals. Fine discrimination of colours enhances the ability of animals to find food, predators, or mating partners. Using two colour variants of medaka (Oryzias latipes), which mate assortatively depending on visual cues (pale grey versus dark orange), we recently established red colour-blind strains by knocking out the red opsin (long-wavelength-sensitive) genes and elucidated that the fish were indeed insensitive to red light. In the present study, we investigated the mate choice of these red-blind fish. The colour variants with normal colour vision strongly preferred to mate with their own strain. The red-blind ones also preferred their own strain; i.e. they still mated assortatively. However, their preference was significantly weaker than that of fish with normal colour vision. In other words, the red-blind fish showed increased sexual interest in the other colour variant. These results indicated that reduced sensitivity to red light also reduced their ability to discriminate colours. This empirical evidence directly demonstrates that a change in cone-opsin repertoire changes mating decision behaviours, which would affect gene flow and speciation processes between conspecific colour variants in nature, as suggested in other studies.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

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[PMID]: 29396613
[Au] Autor:Sorokowska A; Oleszkiewicz A; Sorokowski P
[Ad] Address:Smell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Fetscherstr. 74, Haus 5, Keller, 01307, Dresden, Germany. sorokowska@gmail.com.
[Ti] Title:A Compensatory Effect on Mate Selection? Importance of Auditory, Olfactory, and Tactile Cues in Partner Choice among Blind and Sighted Individuals.
[So] Source:Arch Sex Behav;47(3):597-603, 2018 Apr.
[Is] ISSN:1573-2800
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Human attractiveness is a potent social variable, and people assess their potential partners based on input from a range of sensory modalities. Among all sensory cues, visual signals are typically considered to be the most important and most salient source of information. However, it remains unclear how people without sight assess others. In the current study, we explored the relative importance of sensory modalities other than vision (smell, touch, and audition) in the assessment of same- and opposite-sex strangers. We specifically focused on possible sensory compensation in mate selection, defined as enhanced importance of modalities other than vision among blind individuals in their choice of potential partners. Data were obtained from a total of 119 participants, of whom 78 were blind people aged between 16 and 65 years (M = 42.4, SD = 12.6; 38 females) and a control sample of 41 sighted people aged between 20 and 64. As hypothesized, we observed a compensatory effect of blindness on auditory perception. Our data indicate that visual impairment increases the importance of audition in different types of social assessments for both sexes and in mate choice for blind men.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Data-Review
[do] DOI:10.1007/s10508-018-1156-0

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[PMID]: 29321376
[Au] Autor:Rajagopal R; Zhang S; Wei X; Doggett T; Adak S; Enright J; Shah V; Ling G; Chen S; Yoshino J; Hsu FF; Semenkovich CF
[Ad] Address:Department of Ophthalmology and Visual Sciences.
[Ti] Title:Retinal de novo lipogenesis coordinates neurotrophic signaling to maintain vision.
[So] Source:JCI Insight;3(1), 2018 Jan 11.
[Is] ISSN:2379-3708
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Membrane lipid composition is central to the highly specialized functions of neurological tissues. In the retina, abnormal lipid metabolism causes severe forms of blindness, often through poorly understood neuronal cell death. Here, we demonstrate that deleting the de novo lipogenic enzyme fatty acid synthase (FAS) from the neural retina, but not the vascular retina, results in progressive neurodegeneration and blindness with a temporal pattern resembling rodent models of retinitis pigmentosa. Blindness was not rescued by protection from light-evoked activity; by eating a diet enriched in palmitate, the product of the FAS reaction; or by treatment with the PPARα agonist fenofibrate. Vision loss was due to aberrant synaptic structure, blunted responsiveness to glial-derived neurotrophic factor and ciliary neurotrophic factor, and eventual apoptotic cell loss. This progressive neurodegeneration was associated with decreased membrane cholesterol content, as well as loss of discrete n-3 polyunsaturated fatty acid- and saturated fatty acid-containing phospholipid species within specialized membrane microdomains. Neurotrophic signaling was restored by exogenous cholesterol delivery. These findings implicate de novo lipogenesis in neurotrophin-dependent cell survival by maintaining retinal membrane configuration and lipid composition, and they suggest that ongoing lipogenesis may be required to prevent cell death in many forms of retinopathy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:Publisher

  6 / 68282 MEDLINE  
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[PMID]: 29524101
[Au] Autor:Uyaroglu OA; Seyhoglu E; Erden A; Vahabov C; Babaoglu H; Armagan B; Sari A; Kilic L; Tatar O; Bilgen SA; Karadag O; Kalyoncu U
[Ad] Address:Department of Internal Medicine, Hacettepe University Faculty of Medicine, Sihhiye, 06100, Ankara, Turkey. oguzuyaroglu@gmail.com.
[Ti] Title:Frequency of Behçet's disease among a group of visually impaired adults.
[So] Source:Ir J Med Sci;, 2018 Mar 09.
[Is] ISSN:1863-4362
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:BACKGROUND: Behçet's disease (BD) is one of the reasons of acquired visual impairment among young adults. Ocular involvement is a significant cause of disability in BD. The objective of this study is to assess the prevalence of BD among a group of adults who has visual impairment. METHODS: Ankara Metropolitan Municipality Education and Technology Center is one of the official institutions which records and follows the demographic data of visually impaired people in Turkey. In November 2014, there were 675 visually impaired people recorded at this center. Medical history was taken from 294 adults by phone in November and December of 2014. Participants were asked if the visual impairment had been either acquired or congenital. If the patients had BD or suspicious BD, they were recalled for detailed investigation which would be carried out by an internist, a rheumatologist and an ophthalmologist. RESULTS: Two hundred thirteen of 294 (72.4%) visually impaired adults were male. One hundred nine of 294 (37.1%) had acquired visual impairment. Six (5.5%) of those 109 patients had BD. Overall prevalence of BD among study group was 2.04%.The median age of people with BD was 35 years. The median age at BD diagnosis was 16.5 years and the median duration from diagnosis to visual loss was 2.5 years. CONCLUSION: BD is still one of the causes of acquired visual impairment in Turkey. In this study, BD prevalence among a visually impaired adult group was 2.04%. BD accounted for 5.5% among adults who had acquired visual impairment. In a study of 1965, BD prevalence among people with acquired blindness was 12%. However, this study was conducted at pre-immunosuppressive period. Our prevalence is obviously lower than those studies. Extended population-based studies are needed for population estimations.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher
[do] DOI:10.1007/s11845-018-1783-4

  7 / 68282 MEDLINE  
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[PMID]: 29523021
[Au] Autor:Brian A; Taunton S; Lieberman LJ; Haibach-Beach P; Foley J; Santarossa S
[Ad] Address:1 University of South Carolina.
[Ti] Title:Psychometric Properties of the Test of Gross Motor Development-3 for Children With Visual Impairments.
[So] Source:Adapt Phys Activ Q;:1-14, 2018 Mar 09.
[Is] ISSN:1543-2777
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Results of the Test of Gross Motor Development-2 (TGMD-2) consistently show acceptable validity and reliability for children/adolescents who are sighted and those who have visual impairments. Results of the Test of Gross Motor Development-3 (TGMD-3) are often valid and reliable for children who are sighted, but its psychometric properties are unknown for children with visual impairments. Participants (N = 66; M = 12.93, SD = 2.40) with visual impairments completed the TGMD-2 and TGMD-3. The TGMD-3 results from this sample revealed high internal consistency (ω = .89-.95), strong interrater reliability (ICC = .91-.92), convergence with the TGMD-2 (r = .96), and good model fit, χ (63) = 80.10, p = .072, χ /df ratio = 1.27, RMSEA = .06, CFI = .97. Researchers and practitioners can use the TGMD-3 to assess the motor skill performance for children/adolescents with visual impairments and most likely produce results that are valid and reliable.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher
[do] DOI:10.1123/apaq.2017-0061

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[PMID]: 29522511
[Au] Autor:Hocking JC; Famulski JK; Yoon KH; Widen SA; Bernstein CS; Koch S; Weiss O; Agarwala S; Inbal A; Lehmann OJ; Waskiewicz AJ; FORGE Canada Consortium
[Ad] Address:Division of Anatomy, Department of Surgery, University of Alberta, Edmonton, Canada.
[Ti] Title:Morphogenetic defects underlie Superior Coloboma, a newly identified closure disorder of the dorsal eye.
[So] Source:PLoS Genet;14(3):e1007246, 2018 Mar 09.
[Is] ISSN:1553-7404
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The eye primordium arises as a lateral outgrowth of the forebrain, with a transient fissure on the inferior side of the optic cup providing an entry point for developing blood vessels. Incomplete closure of the inferior ocular fissure results in coloboma, a disease characterized by gaps in the inferior eye and recognized as a significant cause of pediatric blindness. Here, we identify eight patients with defects in tissues of the superior eye, a congenital disorder that we term superior coloboma. The embryonic origin of superior coloboma could not be explained by conventional models of eye development, leading us to reanalyze morphogenesis of the dorsal eye. Our studies revealed the presence of the superior ocular sulcus (SOS), a transient division of the dorsal eye conserved across fish, chick, and mouse. Exome sequencing of superior coloboma patients identified rare variants in a Bone Morphogenetic Protein (Bmp) receptor (BMPR1A) and T-box transcription factor (TBX2). Consistent with this, we find sulcus closure defects in zebrafish lacking Bmp signaling or Tbx2b. In addition, loss of dorsal ocular Bmp is rescued by concomitant suppression of the ventral-specific Hedgehog pathway, arguing that sulcus closure is dependent on dorsal-ventral eye patterning cues. The superior ocular sulcus acts as a conduit for blood vessels, with altered sulcus closure resulting in inappropriate connections between the hyaloid and superficial vascular systems. Together, our findings explain the existence of superior coloboma, a congenital ocular anomaly resulting from aberrant morphogenesis of a developmental structure.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1371/journal.pgen.1007246

  9 / 68282 MEDLINE  
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[PMID]: 29505511
[Au] Autor:Grzybowski A; Elikowski W; Gaca-Wysocka M
[Ad] Address:Department of Ophthalmology, Poznan City Hospital, Poznan.
[Ti] Title:Cardiovascular risk factors in patients with combined central retinal vein occlusion and cilioretinal artery occlusion: Case report.
[So] Source:Medicine (Baltimore);97(1):e9255, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: To analyze cardiovascular risk factors and comorbidity of acute unilateral visual loss due to combined central retinal vein occlusion (CRVO) and cilioretinal artery occlusion (CLRAO). PATIENT CONCERNS: Among patients with retinal vein or artery occlusion hospitalized at the Department of Ophthalmology between January 2011 and August 2017, subjects with combined CRVO/CLRAO were selected. All of them underwent ophthalmologic and cardiologic examination, including fluorescein angiography, optical coherence tomography, 12-lead electrocardiogram, transthoracic and transesophageal echocardiography, carotid Doppler sonography, cerebral magnetic resonance imaging, and a panel of laboratory tests. DIAGNOSES: Four subjects with coexisting CRVO and CLRAO were found among 146 patients with retinal vein or artery occlusion. There were no other types of concomitance of CRVO and retinal artery occlusion. INTERVENTIONS: All patients were treated with low molecular heparin in a full dose for 2 weeks, then with 1 mg/kg once daily for the next 2 weeks, followed by acetylsalicylic acid 75 mg/kg/d. Other medication included long-term statins, angiotensin-converting-enzyme inhibitor in 3 patients and beta-blocker in one patient. OUTCOMES: All patients with CRVO/CLRAO presented multiple cardiovascular risk factors, including hypertension, obesity, hyperlipidemia, chronic nicotine addiction, and a positive family history of coronary artery disease or stroke. In all of them, echocardiography revealed left ventricular hypertrophy and atherosclerotic lesions in the descending aorta; in addition, 3 patients had insignificant atherosclerotic plaques in the carotid artery. Also, in 3 subjects, focal ischemic cerebral changes were diagnosed. LESSONS: Patients with combined CRVO and CLRAO present numerous cardiovascular risk factors and abnormalities on imaging examinations, which should be routinely evaluated and treated.
[Mh] MeSH terms primary: Retinal Artery Occlusion/complications
Retinal Vein Occlusion/complications
Vision Disorders/etiology
[Mh] MeSH terms secundary: Adult
Aged, 80 and over
Carotid Arteries/diagnostic imaging
Child, Preschool
Echocardiography, Transesophageal
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Neuroimaging
Retinal Artery Occlusion/diagnostic imaging
Retinal Vein Occlusion/diagnostic imaging
Risk Factors
Vision Disorders/diagnostic imaging
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180306
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009255

  10 / 68282 MEDLINE  
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[PMID]: 29499674
[Au] Autor:Casas P; Ascaso FJ; Vicente E; Tejero-Garcés G; Adiego MI; Cristóbal JA
[Ad] Address:Department of Ophthalmology, Hospital Clínico Universitario "Lozano Blesa", San Juan Bosco 15, ES-50009, Zaragoza, Spain. paulacasaspascual@hotmail.com.
[Ti] Title:Visual field defects and retinal nerve fiber imaging in patients with obstructive sleep apnea syndrome and in healthy controls.
[So] Source:BMC Ophthalmol;18(1):66, 2018 Mar 02.
[Is] ISSN:1471-2415
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: To assess the retinal sensitivity in obstructive sleep apnea hypopnea syndrome (OSAHS) patients evaluated with standard automated perimetry (SAP). And to correlate the functional SAP results with structural parameters obtained with optical coherence tomography (OCT). METHODS: This prospective, observational, case-control study consisted of 63 eyes of 63 OSAHS patients (mean age 51.7 ± 12.7 years, best corrected visual acuity ≥20/25, refractive error less than three spherical or two cylindrical diopters, and intraocular pressure < 21 mmHg) who were enrolled and compared with 38 eyes of 38 age-matched controls. Peripapillary retinal nerve fiber layer (RNFL) thickness was measured by Stratus OCT and SAP sensitivities and indices were explored with Humphrey Field Analyzer perimeter. Correlations between functional and structural parameters were calculated, as well as the relationship between ophthalmologic and systemic indices in OSAHS patients. RESULTS: OSAHS patients showed a significant reduction of the sensitivity for superior visual field division (p = 0.034, t-student test). When dividing the OSAHS group in accordance with the severity of the disease, nasal peripapillary RNFL thickness was significantly lower in severe OSAHS than that in controls and mild-moderate cases (p = 0.031 and p = 0.016 respectively, Mann-Whitney U test). There were no differences between groups for SAP parameters. We found no correlation between structural and functional variables. The central visual field sensitivity of the SAP revealed a poor Pearson correlation with the apnea-hipopnea index (0.284, p = 0.024). CONCLUSIONS: Retinal sensitivity show minor differences between healthy subjects and OSAHS. Functional deterioration in OSAHS patients is not easy to demonstrate with visual field examination.
[Mh] MeSH terms primary: Nerve Fibers/pathology
Optic Nerve Diseases/etiology
Retinal Ganglion Cells/pathology
Sleep Apnea, Obstructive/complications
Vision Disorders/etiology
Visual Fields
[Mh] MeSH terms secundary: Case-Control Studies
Female
Healthy Volunteers
Humans
Male
Middle Aged
Optic Nerve Diseases/diagnosis
Prospective Studies
Sleep Apnea, Obstructive/diagnosis
Tomography, Optical Coherence
Vision Disorders/diagnosis
Visual Field Tests
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:180304
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0728-z


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