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[PMID]: 29457484
[Au] Autor:Soong LC; Keeling CP
[Ad] Address:1 University of Alberta, Edmonton, AB, Canada.
[Ti] Title:Cryosurgery + 5% 5-Fluorouracil for Treatment of Superficial Basal Cell Carcinoma and Bowen's Disease.
[So] Source:J Cutan Med Surg;:1203475418758973, 2018 Feb 01.
[Is] ISSN:1615-7109
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Superficial basal cell carcinoma (sBCC) and squamous cell carcinoma in situ (SCCis) are 2 types of nonmelanoma skin cancers (NMSCs) that are amenable to treatment with topical 5-fluorouracil, cryosurgery, or topical imiquimod, among other destructive and surgical modalities. There are few studies examining the effectiveness of combination therapy with 5% 5-fluorouracil and cryosurgery for the treatment of sBCC and SCCis. OBJECTIVES: Our objective was to study the clinical cure rate achieved with the regimen of cryosurgery and a 3-week course of 5% 5-fluorouracil in the treatment of biopsy-proven sBCC and SCCis. METHODS: A retrospective chart review of patients treated with cryosurgery and a 3-week course of 5% 5-fluorouracil was performed. Immunocompetent patients with biopsy-proven sBCC or SCCis who completed the treatment and attended a follow-up appointment at 6 months were included in the study. RESULTS: On clinical examination, 30 sBCC lesions of the 34 that were assessed and 31 SCCis lesions of the 33 that were assessed demonstrated no evidence of recurrence. The clinical cure rates were found to be 73% (sBCC) and 82% (SCCis), with the inclusion of patients that were lost to follow-up. CONCLUSIONS: This approach may represent a suitable option for select patients for the treatment of SCCis. Further studies with a longer follow-up duration, documentation of histologic cure, and tolerability of this regimen for SCCis are needed. The effectiveness of cryosurgery and 5-fluorouracil for sBCC requires further study.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180219
[Lr] Last revision date:180219
[St] Status:Publisher
[do] DOI:10.1177/1203475418758973

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[PMID]: 29454900
[Au] Autor:Fernández-Guarino M; Morales MLG; Bernal I; Adrada AIS; Ugia SP; Garde JB
[Ad] Address:Department of Dermatology, Hospital Central de la Cruz Roja, Madrid, Spain. Electronic address: montsefdez@msn.com.
[Ti] Title:IMMUNOHISTOCHEMICAL INVESTIGATION OF PREDICTORS OF RESPONSE OR AGRESSIVITY OF BOWEN DISEASE AFTER PHOTODYNAMIC THERAPY.
[So] Source:Photodiagnosis Photodyn Ther;, 2018 Feb 15.
[Is] ISSN:1873-1597
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:BACKGROUND: Photodynamic therapy (PDT) is a good option for the treatment of Bowen's disease (BD) but, BD occasionally develops into a squamous cell carcinoma (SCC) after PDT. OBJECTIVE: Find predictors of aggressiveness of BD after PDT METHODS: Two biopsies of patients with BD treated with PDT with progression to SCC within three months were selected for immunohistochemical (IHC) studies. Conventional PDT was applied. IHC analysis was performed together with hematoxylin-eosin in the biopsies prior to and after treatment with PDT. RESULTS: Among the IHC markers studied, none showed different expressions between pre-treatment and post-treatment biopsies except for HSP70 CONCLUSIONS: The expression of Hsp70 in BD may predict future aggressive behaviour in BD when treated with PDT. Nevertheless, due to the small number of biopsies studied, further investigations are required to draw conclusions.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180218
[Lr] Last revision date:180218
[St] Status:Publisher

  3 / 2289 MEDLINE  
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[PMID]: 29417799
[Au] Autor:Morton CA
[Ad] Address:Department of Dermatology, Stirling Community Hospital, Stirling, UK - colin.morton@nhs.net.
[Ti] Title:A synthesis of the world's guidelines on photodynamic therapy for non-melanoma skin cancer.
[So] Source:G Ital Dermatol Venereol;, 2018 Feb 07.
[Is] ISSN:1827-1820
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:Photodynamic therapy (PDT), using topically administered photosensitizing agents, is widely approved as a treatment for certain nonmelanoma skin cancers. As a tissue-sparing non-surgical modality, there is great potential for PDT to enhance the choice of therapies available to treat, and potentially prevent, skin cancer. Treatment-specific guidelines have assessed the evidence for various photosensitizing agents and light sources, dosimetry, and evaluate reported adverse effects. Discomfort is frequently experienced during treatment but no analgesia was required in most pivotal lesion-directed studies. Durability of response has been assessed with studies of PDT for basal cell carcinomas (BCC) extending to 5 years and beyond, 2 years for Bowen's disease and up to 1 year for actinic keratoses (AK). Disease-specific guidelines consider the place for topical PDT in routine clinical practice recognizing that PDT is typically office/clinic-based and usually initiated by specialists. Where updated guidelines are awaited, national and international consensus publications offer recommendations, including on the use of daylight to activate the photosensitiser for treating AK. Reviewed studies indicate equivalent efficacy of daylight PDT, but greatly reduced pain compared with conventional PDT. Guidelines and consensus publications also consider the place of PDT in treating skin lesions arising in organ transplant recipients and in the potential for PDT to delay/prevent the development of nonmelanoma skin cancers. There is now a substantial evidence-base to support the use of topical PDT in routine clinical practice with daylight PDT indicated for AK, providing suitable outside climate, whilst conventional PDT remains suitable for AK, Bowen's Disease, superficial and certain thin nodular BCC.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180208
[Lr] Last revision date:180208
[St] Status:Publisher
[do] DOI:10.23736/S0392-0488.18.05896-0

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[PMID]: 29383745
[Au] Autor:Lee DW; Ahn HH; Kye YC; Seo SH
[Ad] Address:Department of Dermatology, Korea University College of Medicine, Seoul, Korea.
[Ti] Title:Clinical experience of ingenol mebutate gel for the treatment of Bowen's disease.
[So] Source:J Dermatol;, 2018 Jan 31.
[Is] ISSN:1346-8138
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:There are only a few anecdotal case reports about Bowen's disease (BD) treated with ingenol mebutate (IM) gel but no clinical study has been published yet. The aim of this study was to evaluate the effectiveness of IM gel in the treatment of BD and to observe the therapeutic efficacy of IM alone or IM with ablative fractional laser pretreatment. Nineteen patients with BD or squamous cell carcinoma in situ confirmed by skin biopsy were enrolled. IM was applied with 0.015% gel on facial lesions for 3 days consecutively and 0.05% gel on other sites for 2 days consecutively, with a 5-mm application margin around the visible lesion. Nine patients applied IM gel immediately following fractional CO laser treatment. Two patients were lost to follow up and a total of 17 patients were enrolled. Nine patients (9/17, 52.9%) had a clinically complete response at 2 months after treatment. Among the patients treated with the fractional CO laser before applying IM gel, eight (8/9, 88.9%) showed a complete response and one (1/9, 11.1%) showed partial response. Among the patients treated with IM gel alone, only one patient (1/8, 12.5%) showed a complete response, four (4/8, 50%) showed a partial response and three (3/8, 37.5%) did not respond to therapy. IM gel alone seems to have limited value for treatment of BD; however, a combination therapy with the ablative fractional laser can increase its therapeutic effectiveness.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180131
[Lr] Last revision date:180131
[St] Status:Publisher
[do] DOI:10.1111/1346-8138.14240

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[PMID]: 27771123
[Au] Autor:Topin-Ruiz S; Debarre JM; Blanchard E; Kettani S; Valmier PJ; Martin L; Le Corre Y
[Ad] Address:Service de dermatologie, CHU d'Angers, 4, rue Larrey, 49933 Angers cedex 9, France.
[Ti] Title:Hypokératose acrale circonscrite (HAC) : utilité diagnostique de la dermoscopie. [Circumscribed palmar hypokeratosis (CPM): The diagnostic value of dermoscopy].
[So] Source:Ann Dermatol Venereol;144(3):197-202, 2017 Mar.
[Is] ISSN:0151-9638
[Cp] Country of publication:France
[La] Language:fre
[Ab] Abstract:BACKGROUND: Circumscribed palmar hypokeratosis (CPH) is a rare skin disease, first described in 2002, associated with sudden localized reduction of the corneal layer. In most cases, it presents as an isolated rounded erythematous palmar lesion on the thenar eminence. We describe the dermoscopic semiology of CPH in 3 cases. PATIENTS AND METHODS: Three patients between the ages of 59 and 72 presented very limited erythematous lesions suggestive of CPH. Dermoscopic examination of these lesions provided similar findings. Biopsy, which was performed in one patient, confirmed the diagnosis of CPH. RESULTS: Two dermoscopic elements of CPH are characteristic: (1) the sides of the lesion have a "stair step" or "geological strata" type of configuration, and the thickness of the different strata varies; (2) the centre of the lesion showed a homogeneous erythematous area with a vascular pattern composed of dotted vessels of the superficial dermis and sometime vascular loops. DISCUSSION: These dermoscopic aspects are characteristic and enable CPH to be differentiated from Bowen's disease or porokeratosis of Mibelli. In Bowen's disease, there is no stair step like aspect to the sides of lesions; further, the centre of the lesion shows glomerular vessels (coiled vessels) and/or globular vessels (small red clods). In porokeratosis, peripheral keratotic "white track" structures comprise a single pigmented channel or a double white line. There is no "stair step" or central vascular pattern. CONCLUSION: The dermoscopic semiology of CPH is highly characteristic and enables differentiation from Bowen's disease and porokeratosis.
[Mh] MeSH terms primary: Dermoscopy
Hand Dermatoses/pathology
[Mh] MeSH terms secundary: Aged
Biopsy
Diagnosis, Differential
Female
Humans
Middle Aged
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180126
[Lr] Last revision date:180126
[Js] Journal subset:IM
[Da] Date of entry for processing:161025
[St] Status:MEDLINE

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[PMID]: 29357581
[Au] Autor:Matsuya T; Nakamura Y; Teramoto Y; Shimizu A; Asami Y; Arai E; Yamamoto A
[Ad] Address:Department of Skin Oncology/Dermatology, Saitama Medical University International Medical Center, Saitama, Japan.
[Ti] Title:Image Gallery: Bowen's disease of a nail unit presenting with 'woodgrain appearance' - a new dermoscopic finding.
[So] Source:Br J Dermatol;178(1):e66, 2018 Jan.
[Is] ISSN:1365-2133
[Cp] Country of publication:England
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180123
[Lr] Last revision date:180123
[St] Status:In-Data-Review
[do] DOI:10.1111/bjd.16070

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[PMID]: 27774637
[Au] Autor:Chou TC; Tsai KB; Wu CY; Hong CH; Lee CH
[Ad] Address:Department of Dermatology, Cathay General Hospital, Taipei, Taiwan.
[Ti] Title:Presence of the Merkel cell polyomavirus in Merkel cell carcinoma combined with squamous cell carcinoma in a patient with chronic arsenism.
[So] Source:Clin Exp Dermatol;41(8):902-905, 2016 Dec.
[Is] ISSN:1365-2230
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:We present a case of Merkel cell carcinoma (MCC) coincident with squamous cell carcinoma (SCC) on the breast of a woman with chronic arsenism. This case demonstrates the distinct association of chronic arsenism with two different primary cutaneous carcinomas. Merkel cell polyomavirus (MCPyV) was identified in the lesional skin of the MCC but not in that of the SCC, suggesting there are different interactions of MCPyV in the pathogenesis of SCC and MCC related to arsenic. Physicians need to be vigilant in the occurrence of both SCC and MCC in patients with chronic arsenism. To our knowledge, this is the first study to show the presence of MCPyV in the MCC but not the SCC portion of an arsenic-induced tumour.
[Mh] MeSH terms primary: Arsenic/toxicity
Bowen´s Disease/chemically induced
Breast Neoplasms/virology
Carcinoma, Merkel Cell/virology
Carcinoma, Squamous Cell/virology
Merkel cell polyomavirus/isolation & purification
Neoplasms, Multiple Primary/virology
Polyomavirus Infections/virology
Skin Neoplasms/chemically induced
Tumor Virus Infections/virology
[Mh] MeSH terms secundary: Aged
Female
Humans
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:N712M78A8G (Arsenic)
[Em] Entry month:1801
[Cu] Class update date: 180112
[Lr] Last revision date:180112
[Js] Journal subset:IM
[Da] Date of entry for processing:161025
[St] Status:MEDLINE
[do] DOI:10.1111/ced.12954

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[PMID]: 29311041
[Au] Autor:Peuvrel L; Saint-Jean M; Quereux G; Brocard A; Le Moigne M; Frénard C; Khammari A; Dreno B
[Ad] Address:Department of Dermatology, Nantes University Hospital; INSERM U1232, CIC Biothérapie, Nantes, France.
[Ti] Title:5-fluorouracil chemowraps for the treatment of multiple actinic keratoses.
[So] Source:Eur J Dermatol;27(6):635-640, 2017 Dec 01.
[Is] ISSN:1952-4013
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:Few satisfactory treatment options are available for widespread areas affected by multiple actinic keratoses (AKs). Our primary objective was to assess the response rate to weekly 5-fluorouracil (5-FU) chemowraps on widespread AK lesions, and secondarily to assess tolerability, the percentage of patients with recurrence and time to recurrence, the response rate for patients with associated Bowen's disease (BD), and the percentage of squamous cell carcinomas (SCCs) identified after treatment. We conducted an open study which included all the patients who had been treated with weekly 5-FU chemowraps in our department over the course of five years for areas of widespread AKs. The response rate for AKs was 60%, with 20% complete responses among 25 patients after an average of 9.6 sessions (1 to 64). The treatment had to be discontinued because of toxicity in four patients; one case of contact dermatitis, one case of erosive pustular dermatosis, and two cases of Grade 2 irritations. Invasive SCCs were identified in five patients after treatment cessation. The median recurrence-free survival was five months. A 64% response rate was achieved for associated BD. The weekly application of 5-FU under occlusion seems to be an interesting, well-tolerated therapeutic option for the treatment of widespread AKs.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180109
[Lr] Last revision date:180109
[St] Status:In-Process
[do] DOI:10.1684/ejd.2017.3128

  9 / 2289 MEDLINE  
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[PMID]: 29307647
[Au] Autor:Funk-Debleds P; Ducroux E; Guillaud O; Ursic-Bedoya J; Decullier E; Vallin M; Euvrard S; Pageaux GP; Boillot O; Dumortier J
[Ad] Address:Hospices Civils de Lyon, Edouard Herriot Hospital, Department of Digestive Diseases, Lyon, France.
[Ti] Title:Subsequent non-melanoma skin cancers and impact of immunosuppression in liver transplant recipients.
[So] Source:J Am Acad Dermatol;, 2018 Jan 04.
[Is] ISSN:1097-6787
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Non-melanoma skin cancers (NMSC) are the most frequent cancers in solid organ transplant recipients, with a high rate of subsequent tumors. OBJECTIVES: To describe subsequent NMSC in a large cohort of liver transplant recipients (LTR) with long follow-up, and to analyze the factors influencing it, including immunosuppressive regimen. METHODS: Ninety-eight LTR (76 male) with a personal post-transplant history of squamous-cell carcinoma (SCC), basal-cell carcinoma (BCC) or Bowen's disease were included, with a median follow-up of 12.4 years (range: 1.5-27.8) after liver transplantation. RESULTS: Median follow-up after first NMSC was 6.4 years (range: 0.17-22.1). Fifty-two (53.1%) patients developed 141 subsequent NMSC with a BCC/SCC ratio of 1.8:1. The actuarial risk of developing a second NMSC was 13.7% at 1 year, 28.4% at 2 years, 49.4% at 5 years, 65.7% at 10 years, and 88.4% at 15-years. Multivariate analysis found that phototype I-II (vs. III-IV) was a significant risk factor for second NMSC (HR: 2.556, 95%CI [1.45; 4.48], p=0.001), whereas withdrawal of calcineurin inhibitors (CNI) was significantly protective (HR: 0.358, 95%CI [0.142; 0.902], p=0.029). LIMITATIONS: Retrospective analysis. CONCLUSIONS: Subsequent NMSC are very frequent in LTR and conversion from CNI-based immunosuppressive regimen to mTORi/antimetabolite-based immunosuppressive regimen can reduce subsequent NMSC.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180108
[Lr] Last revision date:180108
[St] Status:Publisher

  10 / 2289 MEDLINE  
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[PMID]: 29237947
[Au] Autor:Zhu T; Wang T; Ma DL; Wang YN; Li L
[Ad] Address:Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
[Ti] Title:A Case of Pagetoid Bowen's Disease.
[So] Source:Chin Med J (Engl);130(24):3023-3024, 2017 Dec 20.
[Is] ISSN:0366-6999
[Cp] Country of publication:China
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1712
[Cu] Class update date: 180103
[Lr] Last revision date:180103
[St] Status:In-Data-Review
[do] DOI:10.4103/0366-6999.220315


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