Database : MEDLINE
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[PMID]: 25372646
[Au] Autor:Zhang R; Chen W; Hu Q; Shrestha S
[Ad] Address:Department of Ophthalmology, Shaoxing Peoples Hospital, Shaoxing 312000, China;College of Optometry, Wenzhou Medical University, Wenzhou 325027, China....
[Ti] Title:[Adult Sturge-Weber syndrome without facial hemangioma:report of one case].
[So] Source:Zhejiang Da Xue Xue Bao Yi Xue Ban;43(5):588-90, 2014 Sep 25.
[Is] ISSN:1008-9292
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:Sturge-Weber syndrome (SWS) is characterized by angiomas affecting the ophthalmic division of the trigeminal nerve, epilepsy, intellectual impairment, hemiplegia and glaucoma. We report a patient who developed SWS without facial hemangioma (SWS type Ⅲ) in his adulthood. The patient presented with repeated episodes of headache since age 37 year. He manifested first attack of seizure at the age 47 year followed by aphasia and right upper limb palsy. Brain CT scan revealed right parietal-occipital calcification, brain CT angiography showed right temporal lobe and occipital lobe vascular malformation, and MRI showed leptomeningeal enhancement in the riht cerebral piamater. The seizure was controlled with antiepileptic drugs and reviewed in routine follow up.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review

  2 / 1245279 MEDLINE  
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[PMID]: 25372645
[Au] Autor:Wu XQ; Zhang BR
[Ad] Address:Department of Neurology,Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China.
[Ti] Title:[Bilateral middle cerebellar peduncle infarcts caused by bilateral vertebral artery occlusion: a case report].
[So] Source:Zhejiang Da Xue Xue Bao Yi Xue Ban;43(5):583-7, 2014 Sep 25.
[Is] ISSN:1008-9292
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:Patients with bilateral vertebral artery occlusion have a high incidence of cerebral infarction with poor prognosis. Infarction of bilateral middle cerebellar peduncle (MCP) is extremely rare and only a few cases have been reported in literature. A 74-year-old male patient was admitted to our hospital with a chief complaint of dizziness and walking instability for 13 d. Brain magnetic resonance image showed acute bilateral middle cerebellar peduncle infarction. Digital subtraction angiography showed occlusion of the initiation part of left vertebral artery and whole right vertebral artery, while a large amount of collateral circulations and recanalization were observed. After volume expansion, anti-platelet aggregation and lipid-lowering therapy, the symptoms disappeared. The patient was followed up for 10 months and he recovered well.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review

  3 / 1245279 MEDLINE  
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[PMID]: 25372637
[Au] Autor:Yi ZX; Zhang W
[Ad] Address:Department of Nuclear Medicine, Dongyang People's Hospital, Dongyang 322100, China.
[Ti] Title:[Effect of cerebral X-ray irradiation on learning and memory function in young SD rats].
[So] Source:Zhejiang Da Xue Xue Bao Yi Xue Ban;43(5):535-40, 2014 Sep 25.
[Is] ISSN:1008-9292
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE: To investigate the effect of cerebral X-ray irradiation on learning and memory function in young rats. METHODS:Fifty-four SD rats aged 35 d were randomly divided into 3 groups with 18 in each group: rats in 3-d group and 7-d group received X-ray irradiation with a dose of 28.5 mGy/d for 3 d and 7 d,respectively; rats in control group received sham X-ray irradiation. Morris water maze (MWM) was tested when animals at age of 60 d; then the animals were sacrificed and brain samples were taken. The neurodegeneration was observed by Fluro-Jade B staining; the expression of N-methyl-aspartate (NMDA) receptors subunit 2B (NR2B) and postsynaptic density protein-95 (PSD-95) in the hippocampus were analyzed by immunofluorescence and Western blot methods,respectively,and ultrastructure of CA1 region was observed with electron microscopy. RESULTS: No significant difference in 1-4 d escape latency as shown in MWM test was noted between 3d group and control group (P>0.05); while the escape latency in 7d group was significantly longer than that in control group (P<0.01). No significant differences in lingering in the quadrant and the frequency of passing through the original platform between 3-d group and control group (P>0.05),while those in 7-d group were significantly lower than those in control group (P<0.01). Compared to control group,the number of FJB positive cells in 7-d group was increased (P<0.01); the expressions of NR2B and PSD-95 in hippocampus CA1 region were also increased (P<0.05). The ultrastructure observation in 7-d group showed that the synapse structure of some neurons was impaired. CONCLUSION: X-ray irradiation may affect learning and memory function of young rats,which is associated with overexpression of NR2B and PSD-95 in hippocampal regions.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review

  4 / 1245279 MEDLINE  
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[PMID]: 25372634
[Au] Autor:Wen M; Dong Z; Cui J
[Ad] Address:College of Food Science and Technology, Ocean University of China, Qingdao 266003, China.
[Ti] Title:[Effects of feeding mode on biological clock and circadian expression of lipid metabolismrela ted genes in mice].
[So] Source:Zhejiang Da Xue Xue Bao Yi Xue Ban;43(5):513-20, 2014 Sep 25.
[Is] ISSN:1008-9292
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:OBJECTIVE:To explore the effects of feeding mode on biological clock and circadian expression of lipids metabolism-related genes in mice. METHODS:Ninety healthy male ICR mice were divided into 3 groups with 30 in each: ad libitum-feeding, daytime-feeding and nighttime-feeding groups, in a 12 h to 12 h light-dark cycle. After two weeks of feeding the animals was sacrificed in batches (5 in each batch) at 4, 8, 12, 16, 20 and 24 h, the circadian expression of lipids metabolism-related genes in the liver and brain was detected by real time quantitative RT PCR at 6 time points. RESULTS:The circadian oscillator in the brain was more sensitive to alteration of feeding mode than that in the liver, nighttime feeding decreased peak mRNA levels of Cry2, Per1, and Per2 (5.5, 4.3 and 7.1 folds, respectively) in the brain. However, there was no difference in the expression rhythm of hepatic clock genes between nighttime-feeding and ad libitum group. In addition, changed feeding mode significantly decreased the peak value of Rev erbα (2 folds for daytime feeding, 3.4 folds for nighttime feeding) and Dbp (10.6 folds for daytime feeding, 2.8 folds for nighttime feeding), which two had opposite expression mode in different feeding modes. Different expression rhythm of lipid metabolismrelated genes SREBP1-c, PPARα, FAS, and CPT was shown with decreased mRNA expression levels of SREBP1-c and PPARα in daytime feeding (5.5 folds, 4 folds) and nighttime feeding (4.4 folds, 4.8 folds). CONCLUSION:Changing the feeding mode could entrain circadian oscillators both in the brain and liver. What is more, hepatic circadian oscillators couple with the feeding time.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review

  5 / 1245279 MEDLINE  
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[PMID]: 25374951
[Au] Autor:Tandon A; Alzate J; LaSala P; Fried MP
[Ad] Address:Department of Neurosurgery, Montefiore Medical Center, 3316 Rochambeau Avenue, Bronx, NY 10467, USA....
[Ti] Title:Endoscopic Endonasal Transsphenoidal Resection for Pituitary Apoplexy during the Third Trimester of Pregnancy.
[So] Source:Surg Res Pract;2014:397131, 2014.
[Is] ISSN:2356-7759
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Pituitary apoplexy is an uncommon phenomenon typically characterized by vascular insufficiency or acute hemorrhage into a pituitary adenoma. The overall incidence of pituitary apoplexy ranges between 1 and 25% of all pituitary adenomas. With the widespread use of MRI technology, the diagnosis of asymptomatic intratumoral hemorrhage is closer to 10%. The authors report a case of a 27-year-old female in her 36th week of pregnancy who presented with severe onset headache and acute left-sided vision loss. MRI of the brain revealed a large hemorrhagic mass occupying the sella turcica. The patient underwent an emergent endoscopic endonasal transsphenoidal resection for pituitary apoplexy. Postoperatively, the patient's neurologic deficit resolved. Minimally invasive endoscopic endonasal transsphenoidal resection of pituitary apoplexy can be safely utilized in third trimester pregnant women presenting with acute severe neurologic deficits.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Da] Date of entry for processing:141106
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1155/2014/397131

  6 / 1245279 MEDLINE  
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[PMID]: 25372441
[Au] Autor:Yu S; Yannuzzi LA
[Ad] Address:*Department of Ophthalmology, Shanghai Jiaotong University Affiliated Shanghai First People's Hospital, Shanghai, China; Vitreous, Retina, Macula Consultants of New York, New York, New York; and Columbia University School of Medicine, New York, New York.
[Ti] Title:Bilateral perifoveal macular ischemia in sarcoidosis.
[So] Source:Retin Cases Brief Rep;8(3):212-4, 2014.
[Is] ISSN:1937-1578
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: To represent and evaluate the findings of bilateral perifoveal macular ischemia in a patient with biopsy-proven, multiorgan involved sarcoidosis. METHODS: Case report. A 55-year-old man, with a medical history of pulmonary disease, experienced reduced vision bilaterally. General ocular examination, fundus color photographs, fluorescence angiography, and high-resolution spectral domain optical coherence tomography were performed in both eyes. RESULTS: The patient's visual acuity was 20/200 in the right eye and 20/30 in the left eye with normal intraocular pressure and anterior segment. Fundus examination showed symmetric changes with the loss of transparency in macular and small intraretinal hemorrhages in both eyes. Fluorescence angiography demonstrated markedly enlarged avascular zone while optical coherence tomography revealed marked cystic change in the macula bilaterally. A series of blood test was conducted without a specific diagnosis. A lung biopsy confirmed the diagnosis of pulmonary sarcoidosis, and a magnetic resonance imaging of his brain revealed neurosarcoidosis. CONCLUSION: Bilateral perifoveal ischemia, formerly one of the three idiopathic macular telangiectasia diseases, is rare and usually suggests a systemic etiology. It is not unexpected that sarcoidosis, a multisystem, chronic inflammatory disorder, may affect retinal vessels and be associated with this peculiar form of ischemia and edema.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1097/ICB.0000000000000045

  7 / 1245279 MEDLINE  
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[PMID]: 25372435
[Au] Autor:Buelens T; Herode L; Nubourgh I; Caspers L; Willermain F; Postelmans L
[Ad] Address:Departments of *Ophthalmology, CHU Saint-Pierre and Brugmann, and General Internal Medicine, CHU Saint-Pierre, Universit Libre de Bruxelles, Brussels, Belgium.
[Ti] Title:Central retinal artery occlusion and susac syndrome: a case report.
[So] Source:Retin Cases Brief Rep;8(3):187-92, 2014.
[Is] ISSN:1937-1578
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Susac syndrome is a rare disease attributed to microangiopathy involving the arterioles of the brain, retina, and cochlea. Understanding the pathogenesis is incomplete, but an immune-mediated process remains the leading hypothesis. METHODS: Report of a single case of a previously healthy 22-year-old female patient showing the complete clinical triad. RESULTS: Diagnosis of Susac syndrome in this patient was first questioned due to the atypical initial ophthalmologic presentation with central retinal artery occlusion. Multiple relapses occurred in the fellow eye during follow-up, showing the typical branch retinal artery occlusions, allowing definite diagnosis. CONCLUSION: Susac syndrome should be considered in the differential diagnosis when facing (young) patients with central retinal artery occlusion, especially in the presence of unexplained encephalopathy and/or sensorineural hearing loss.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1097/ICB.0000000000000039

  8 / 1245279 MEDLINE  
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[PMID]: 25372323
[Au] Autor:Eisenberg MA; Wilker SC
[Ad] Address:Department of Ophthalmology, University Hospitals Case Medical Center, Cleveland, Ohio.
[Ti] Title:Nocardia asteroides subretinal abscess in patient with acute myelogenous leukemia after allogeneic stem cell transplant.
[So] Source:Retin Cases Brief Rep;8(2):113-5, 2014.
[Is] ISSN:1937-1578
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: Nocardia asteroides is the most common bacterial cause of subretinal abscesses; however, the diagnosis is often delayed because of the lack of suspicion leading to poor visual prognosis and possible enucleation. METHODS: A 40-year-old man with a history of allogeneic stem cell transplant presents with decreased vision and a macular subretinal abscess. RESULTS: Examination revealed decreased vision at 20/100 with a peripapillary creamy subretinal lesion extending to the nasal margin of the fovea associated with intraretinal and subretinal hemorrhages without vitritis. Workup revealed disseminated N. asteroides, confirmed with a skin biopsy with the involvement of skin, eyes, lungs, and brain. Intravitreal amikacin and vancomycin were promptly given along with systemic vancomycin, sulfamethoxazole/trimethoprim, and meropenem. Vision improved rapidly to 20/40 with stabilization and eventual scarring of the lesion. CONCLUSION: This case illustrates that rapid diagnosis and treatment of subretinal N. asteroides can possibly have a good visual outcome and stabilization of the ocular manifestations.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1097/ICB.0000000000000017

  9 / 1245279 MEDLINE  
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[PMID]: 24838368
[Au] Autor:Katsidoni V; Alexiou P; Fotiadou M; Pelecanou M; Sagnou M; Panagis G
[Ad] Address:Laboratory of Behavioral Neuroscience, Department of Psychology, School of Social Sciences, University of Crete, 74100, Rethymno, Crete, Greece.
[Ti] Title:Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit morphine's rewarding effect in rats.
[So] Source:Psychopharmacology (Berl);231(23):4467-78, 2014 Dec.
[Is] ISSN:1432-2072
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:RATIONALE: Recent animal studies reported that curcumin, the active constituent of Curcuma longa, has several central actions and may attenuate morphine tolerance. OBJECTIVES: In the present study, we utilized the intracranial self-stimulation (ICSS) paradigm to examine the effects of the commercially available curcuminoid mixture and each one of its components, individually, on brain stimulation reward and on the reward-facilitating effect of morphine. METHODS: Male Sprague-Dawley rats were implanted with an electrode into the medial forebrain bundle and trained to respond for electrical stimulation using a rate-frequency paradigm. In the first study, rats were injected with graded doses either of the curcuminoid mixture, or curcumin I, or II, or III. In the second study, we examined whether a low dose of the curcuminoid mixture or each individual curcumin analogue composing it could counteract the reward-facilitating effect of morphine. RESULTS: At low doses, both the curcuminoid mixture and curcumin I did not affect brain stimulation reward, whereas, higher doses increased ICSS thresholds. Curcumin II and curcumin III did not affect brain stimulation reward at any doses. Subthreshold doses of the curcuminoid mixture and curcumin I inhibited the reward-facilitating effect of morphine. CONCLUSION: Both the curcuminoid mixture and curcumin I lack hedonic properties and moderate the reward-facilitating effect of morphine. Our data suggest that curcumin interferes with brain reward mechanisms responsible for the expression of the acute reinforcing properties of opioids and provide evidence that curcumin may be a promising adjuvant for attenuating morphine's rewarding effects in patients who are under long-term opioid therapy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s00213-014-3603-5

  10 / 1245279 MEDLINE  
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[PMID]: 24810106
[Au] Autor:Jacobsen JP; Plenge P; Sachs BD; Pehrson AL; Cajina M; Du Y; Roberts W; Rudder ML; Dalvi P; Robinson TJ; O'Neill SP; Khoo KS; Morillo CS; Zhang X; Caron MG
[Ad] Address:Department of Cell Biology, Duke University Medical Center, PO Box 3287, Durham, NC, 27710, USA.
[Ti] Title:The interaction of escitalopram and R-citalopram at the human serotonin transporter investigated in the mouse.
[So] Source:Psychopharmacology (Berl);231(23):4527-40, 2014 Dec.
[Is] ISSN:1432-2072
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:RATIONALE: Escitalopram appears to be a superior antidepressant to racemic citalopram. It has been hypothesized that binding of R-citalopram to the serotonin transporter (SERT) antagonizes escitalopram binding to and inhibition of the SERT, therebycurtailing the elevation of extracellular 5-hydroxytryptamine (5-HTExt), and henceantidepressant efficacy. Further, it has been suggested that a putative allosteric binding site is important for binding of escitalopram to the primary, orthosteric, site, and for R-citalopram's inhibition hereof. OBJECTIVES: Primary: Investigate at the human (h)SERT, at clinical relevant doses, whether R-citalopram antagonizes escitalopram-induced 5-HTExt elevation. Secondary: Investigate whether abolishing the putative allosteric site affects escitalopram-induced 5-HTExt elevation and/or modulates the effect of R-citalopram. METHODS: Recombinant generation of hSERT transgenic mice; in vivo microdialysis; SERT binding; pharmacokinetics; 5-HT sensitive behaviors (tail suspension, marble burying). RESULTS: We generated mice expressing either the wild-type human SERT (hSERT(WT)) or hSERT carrying amino acid substitutions (A505V, L506F, I507L, S574T and I575T) collectively abolishing the putative allosteric site (hSERT(ALI/VFL+SI/TT)). One mg/kg escitalopram yielded clinical relevant plasma levels and brain levels consistent with therapeutic SERT occupancy. The hSERT mice showed normal basal 5-HTExt levels. Escitalopram-induced 5-HTExt elevation was not decreased by R-citalopram co-treatment and was unaffected by loss of the allosteric site. The behavioral effects of the clinically relevant escitalopram dose were small andtendedto be enhanced by R-citalopram co-administration. CONCLUSIONS: We find no evidence that R-citalopram directly antagonizes escitalopram or that the putative allosteric site is important for hSERT inhibition by escitalopram.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1411
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s00213-014-3595-1


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