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[PMID]: 29505522
[Au] Autor:Zhang BJ; Tian HT; Li HO; Meng J
[Ad] Address:Department of Anesthesia, Jining No. 1 People's Hospital, Jining City, Shandong Province, China.
[Ti] Title:The effects of one-lung ventilation mode on lung function in elderly patients undergoing esophageal cancer surgery.
[So] Source:Medicine (Baltimore);97(1):e9500, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The objective of the present study was to explore the effects of different one-lung ventilation (OLV) modes on lung function in elderly patients undergoing esophageal cancer surgery. A total of 180 consecutive elderly patients (ASA Grades I-II, with OLV indications) undergoing elective surgery were recruited in the study. Patients were randomly divided into 4 groups (n = 45). In Group A, patients received low tidal volume (VT < 8 mL/kg) + pressure controlled ventilation (PCV), low tidal volume (VT < 8 mL/kg) + volume-controlled ventilation (VCV) in Group B, high tidal volume (VT ≥ 8 mL/kg) + PCV in Group C and high tidal volume (VT ≥ 8 mL/kg) + VCV in Group D. Two-lung ventilation involved routine tidal volume (8-10 mL/kg) at a frequency of 12 to 18 times/min, and VCV mode. Clinical efficacy among 4 groups was compared. The partial pressure of end-tidal carbon dioxide (PetCO2) did not significantly differ among 4 groups (all P > .05), and the oxygenation index and SO2 in Group A were significantly higher than in the other groups (P < .05). The PetCO2, peak airway pressure (Ppeak), platform airway pressure (Pplat), and mean airway pressure (Pmean) in Group A were significantly lower than those in the other groups (all P < .05). However, airway resistance (Raw) among 4 groups did not significantly differ (all P > .05). The incidence of pulmonary infection, anastomotic fistula, ventilator-induced lung injury, lung dysfunction, difficulty weaning from mechanical ventilation, and multiple organ dysfunction in Groups A and B were lower than that in Groups C and D (all P < .05). The expression levels of IL-6, tumor necrosis factor-α, and C-reactive protein in lavage fluid in Group A were significantly lower than those in the other groups (all P < .05). OLV with low tidal volume (VT < 8 mL/kg) + PCV (5 cmH2O PEEP) improved lung function and mitigated inflammatory responses in elderly patients undergoing esophageal cancer surgery.
[Mh] MeSH terms primary: Esophageal Neoplasms/surgery
One-Lung Ventilation/methods
[Mh] MeSH terms secundary: Aged
Bronchoalveolar Lavage Fluid/chemistry
C-Reactive Protein/analysis
Female
Humans
Interleukin-6/analysis
Male
Middle Aged
Respiratory Function Tests
Tumor Necrosis Factor-alpha/analysis
[Pt] Publication type:JOURNAL ARTICLE; OBSERVATIONAL STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Name of substance:0 (IL6 protein, human); 0 (Interleukin-6); 0 (Tumor Necrosis Factor-alpha); 9007-41-4 (C-Reactive Protein)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180306
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009500

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[PMID]: 29519996
[Au] Autor:AlAmodi AA; Farhoud MH; Mohammad N; Alatassi R; Alolayet D; AlQeshtaini N; AlMamlouk R; Ahmed MH; Ashour M; Kayyali SS; AlShammari A
[Ad] Address:College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
[Ti] Title:Sterile Bronchopleural Fistula Following Surgical Removal of Primary Lung Leiomyoma Inducing Secondary Hypertrophic Osteoarthropathy.
[So] Source:Am J Case Rep;19:267-271, 2018 Mar 09.
[Is] ISSN:1941-5923
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND Leiomyomas are benign neoplasms of the smooth muscle. When found in the pulmonary system, a rare occurrence, leiomyomas can result in hypertrophic osteoarthropathy, or significant clubbing, associated with proliferation of long bone periosteum. Bronchopulmonary fistulas, or communications between the bronchial tree and pleural space, are an uncommon postoperative complication of pneumonectomies. Even more infrequent is the presence of a bronchopulmonary fistula that is determined to be sterile. CASE REPORT The patient presented in the current case report is a 40-year-old previously healthy woman who presented with a 5-year history of chronic cough, right-sided chest discomfort, and dyspnea associated with back pain, and lower leg pain. The CT scan performed on the patient revealed a mass originating from the right lower lobe. Activity at the site of the lesion, in the long bones of the upper and lower limbs, rib cage, and vertebral bones was demonstrated by a bone scan. A CT-guided biopsy was performed, and the pathology report confirmed the presence of a leiomyoma. Following a right-sided lobectomy, the resected tumor was sent for histopathology, with the results confirming the biopsy. The patient subsequently presented with a history of persistent cough associated with increased watery secretions. The CT scan revealed the presence of a bronchopleural fistula, after which the patient underwent surgical correction. All symptoms resolved, and the patient was discharged in stable condition. CONCLUSIONS Here, we report on a patient who presented with 3 rare clinical findings: pulmonary leiomyoma, hypertrophic osteoarthropathy, and sterile bronchopulmonary fistula.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Process

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[PMID]: 29429160
[Au] Autor:Zhao M; Wang YB; Yan YJ; Wang W; Ru GQ; He XL
[Ad] Address:Department of Pathology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.
[Ti] Title:[Clinicopathologic features of atypical spindle cell lipomatous tumor].
[So] Source:Zhonghua Bing Li Xue Za Zhi;47(2):99-104, 2018 Feb 08.
[Is] ISSN:0529-5807
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:To investigate the clinicopathologic characteristics, immunophenotype, differential and diagnostic features of atypical spindle cell lipomatous tumor (ASLT). Three cases of ASLT were collected from January 2010 to March 2017 at Zhejiang Provincial People's Hospital. The clinical and imaging features, histomorphology, immunophenotype and prognosis were analyzed. Fluorescence in situ hybridization (FISH) was used to detect MDM2 gene amplification, and relevant literature was reviewed. All three patients were adult males, aged 38, 43 and 54 years, respectively. One tumor originated in the subcutaneous soft tissue in the head and neck, one was located in the left primary bronchus and one in the latissimus dorsi muscle. Grossly, all three tumors were circumscribed and ranged from 4.0 to 5.8 cm in size. Microscopically, all showed a focally infiltrative front. These tumors were composed of variable proportions of spindle-shaped and adipocytic cells in a background of variable fibrous and edematous matrix. Scattered lipoblasts were easily seen. One tumor was composed predominately of spindle tumor cells, one of adipocytic cells, and one of equally mixed cell populations. The spindle tumor cells were generally bland-appearing with focal nuclear enlargement and hyperchromasia noted in one case. Mitosis was not seen in neither the spindle cells nor the adipocytic cells. By immunohistochemistry, diffuse and strong reactivity to CD34 of the spindle cells was noted in all cases, definite loss of Rb expression was noted in one of three cases, and S-100 protein was expressed only in the adipocytic cells. INI-1 was intact and Ki-67 index was 1% to 3%. All other markers including CDK4, MDM2, STAT6, SOX10, CD99, bcl-2, -catenin, CD117, GFAP, CK, EMA, SMA and desmin were negative. FISH of MDM2 was done in two cases, and both showed no amplification. The ASLT in the head and neck had two recurrences during 17 months of follow-up, whereas the tumor in the latissimus dorsi was free of disease during 33 months of follow-up. ASLT is a rare subtype of low-grade adipocytic neoplasm and is distinctive from atypical lipomatous tumor/well-differentiated liposarcoma. The histomorpholgy of ASLT has significant heterogeneity and forms a continuous spectrum. ASLT needs to be distinguished from a series of benign and malignant soft tissue tumors.
[Mh] MeSH terms primary: Bronchial Neoplasms/pathology
Head and Neck Neoplasms/pathology
Lipoma/pathology
Muscle Neoplasms/pathology
[Mh] MeSH terms secundary: Adult
Bronchial Neoplasms/chemistry
Head and Neck Neoplasms/chemistry
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Lipoma/chemistry
Liposarcoma/chemistry
Liposarcoma/pathology
Male
Middle Aged
Muscle Neoplasms/chemistry
Neoplasm Recurrence, Local
S100 Proteins/analysis
STAT6 Transcription Factor/analysis
Superficial Back Muscles
beta Catenin/analysis
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (CTNNB1 protein, human); 0 (S100 Proteins); 0 (STAT6 Transcription Factor); 0 (STAT6 protein, human); 0 (beta Catenin)
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[Js] Journal subset:IM
[Da] Date of entry for processing:180213
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-5807.2018.02.004

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[PMID]: 29223274
[Au] Autor:Roeder NL; Marshall JD; Britto CJ
[Ad] Address:Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT. Electronic address: nicole.roeder@yale.edu.
[Ti] Title:A Woman in Her 60s With Lung Adenocarcinoma Presents With Copious Watery Sputum and Respiratory Failure.
[So] Source:Chest;152(6):e143-e146, 2017 12.
[Is] ISSN:1931-3543
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:CASE PRESENTATION: A woman in her 60s presented with 1month of progressive dyspnea, watery rhinorrhea, and paroxysmal cough productive of clear, watery sputum. She was diagnosed with epidermal growth factor receptor (EGFR) mutation-positive lung adenocarcinoma at another institution 1week prior to presentation and 3weeks after the onset of symptoms. She was a never-smoker. She denied fevers and had completed a course of antibiotics for presumed pneumonia, without clinical improvement. She presented to the hospital due to increasing severity of her shortness of breath.
[Mh] MeSH terms primary: Adenocarcinoma/diagnosis
Lung Neoplasms/diagnosis
Respiratory Insufficiency/etiology
Sputum/chemistry
[Mh] MeSH terms secundary: Adenocarcinoma/complications
Bronchoalveolar Lavage
Diagnosis, Differential
Female
Humans
Lung Neoplasms/complications
Middle Aged
Radiography, Thoracic
Respiratory Insufficiency/diagnosis
Tomography, X-Ray Computed
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:171211
[St] Status:MEDLINE

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[PMID]: 28464886
[Au] Autor:Yeo J; Crawford EL; Zhang X; Khuder S; Chen T; Levin A; Blomquist TM; Willey JC
[Ad] Address:Division of Pulmonary and Critical Care Medicine, Department of Medicine, The University of Toledo College of Medicine, 3000 Arlington Avenue, HEB 219, Toledo, OH, 43614, USA.
[Ti] Title:A lung cancer risk classifier comprising genome maintenance genes measured in normal bronchial epithelial cells.
[So] Source:BMC Cancer;17(1):301, 2017 May 02.
[Is] ISSN:1471-2407
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Annual low dose CT (LDCT) screening of individuals at high demographic risk reduces lung cancer mortality by more than 20%. However, subjects selected for screening based on demographic criteria typically have less than a 10% lifetime risk for lung cancer. Thus, there is need for a biomarker that better stratifies subjects for LDCT screening. Toward this goal, we previously reported a lung cancer risk test (LCRT) biomarker comprising 14 genome-maintenance (GM) pathway genes measured in normal bronchial epithelial cells (NBEC) that accurately classified cancer (CA) from non-cancer (NC) subjects. The primary goal of the studies reported here was to optimize the LCRT biomarker for high specificity and ease of clinical implementation. METHODS: Targeted competitive multiplex PCR amplicon libraries were prepared for next generation sequencing (NGS) analysis of transcript abundance at 68 sites among 33 GM target genes in NBEC specimens collected from a retrospective cohort of 120 subjects, including 61 CA cases and 59 NC controls. Genes were selected for analysis based on contribution to the previously reported LCRT biomarker and/or prior evidence for association with lung cancer risk. Linear discriminant analysis was used to identify the most accurate classifier suitable to stratify subjects for screening. RESULTS: After cross-validation, a model comprising expression values from 12 genes (CDKN1A, E2F1, ERCC1, ERCC4, ERCC5, GPX1, GSTP1, KEAP1, RB1, TP53, TP63, and XRCC1) and demographic factors age, gender, and pack-years smoking, had Receiver Operator Characteristic area under the curve (ROC AUC) of 0.975 (95% CI: 0.96-0.99). The overall classification accuracy was 93% (95% CI 88%-98%) with sensitivity 93.1%, specificity 92.9%, positive predictive value 93.1% and negative predictive value 93%. The ROC AUC for this classifier was significantly better (p<0.0001) than the best model comprising demographic features alone. CONCLUSIONS: The LCRT biomarker reported here displayed high accuracy and ease of implementation on a high throughput, quality-controlled targeted NGS platform. As such, it is optimized for clinical validation in specimens from the ongoing LCRT blinded prospective cohort study. Following validation, the biomarker is expected to have clinical utility by better stratifying subjects for annual lung cancer screening compared to current demographic criteria alone.
[Mh] MeSH terms primary: Biomarkers, Tumor/analysis
Bronchi/cytology
Lung Neoplasms/genetics
Lung Neoplasms/metabolism
[Mh] MeSH terms secundary: Antioxidants/analysis
Antioxidants/metabolism
Biomarkers, Tumor/genetics
Biomarkers, Tumor/metabolism
Biopsy
Bronchi/metabolism
Epithelial Cells/cytology
Epithelial Cells/metabolism
Humans
Lung Neoplasms/diagnosis
Lung Neoplasms/epidemiology
Polymerase Chain Reaction
ROC Curve
Reproducibility of Results
Retrospective Studies
Risk Assessment
Tomography, Spiral Computed
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antioxidants); 0 (Biomarkers, Tumor)
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:IM
[Da] Date of entry for processing:170504
[St] Status:MEDLINE
[do] DOI:10.1186/s12885-017-3287-4

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[PMID]: 29465555
[Au] Autor:Sheth HS; Maldonado F; Lentz RJ
[Ad] Address:D. Y. Patil University School of Medicine, Mumbai, India.
[Ti] Title:Two cases of Dieulafoy lesions of the bronchus with novel comorbid associations and endobronchial ablative management.
[So] Source:Medicine (Baltimore);97(8):e9754, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Dieulafoy lesions are aberrantly large submucosal arteries most frequently associated with gastrointestinal hemorrhage. They are rarely identified in the bronchial submucosa and can cause massive hemoptysis. PATIENT CONCERNS: We present three episodes of massive hemoptysis in two patients, the first with comorbid Alagille syndrome including multiple cardiac and pulmonary vascular abnormalities and the second with thyroid cancer metastatic to the mediastinum. DIAGNOSES: All episodes were due to Dieulafoy lesions of the bronchus based on bronchoscopic appearance. INTERVENTIONS: Bronchoscopic ablation using Nd:YAP laser was attempted both patients. OUTCOMES: Nd:YAP laser successfully ablated the Dieulafoy lesion in the first case with long-term relief from recurrent hemoptysis. The first episode in the second patient responded to bronchial artery embolization; laser ablation of a different Dieulafoy lesion responsible for the second episode was unsuccessful but additional bronchial artery embolization has provided relief from further episodes. LESSONS: Bronchoscopic ablation of Dieulafoy lesions of the bronchus can provide durable relief from recurrent symptoms. Clinical and anatomical features should be considered carefully before intervention, which should only be attempted by experienced operators with appropriate ancillary support available.
[Mh] MeSH terms primary: Ablation Techniques/methods
Bronchial Diseases/surgery
Bronchoscopy/methods
Hemoptysis/surgery
Vascular Malformations/surgery
[Mh] MeSH terms secundary: Aged
Alagille Syndrome/pathology
Bronchi/blood supply
Bronchi/surgery
Bronchial Diseases/complications
Comorbidity
Female
Hemoptysis/etiology
Humans
Male
Mediastinal Neoplasms/secondary
Middle Aged
Thyroid Neoplasms/pathology
Vascular Malformations/complications
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180222
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009754

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[PMID]: 29390285
[Au] Autor:Zhang Y; Xin J; Ma Y; Li Q; Liu B
[Ad] Address:Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
[Ti] Title:Use of Univent tube for intermittent lung isolation during thoracoscopic mediastinal tracheal resection and reconstruction: A case report.
[So] Source:Medicine (Baltimore);96(50):e8945, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Primary tracheal adenoid cystic carcinoma of the trachea primary is a rare neoplasm and commonly misdiagnosed. Lung isolation during surgery and ventilation pose a tremendous challenge to anesthesiologists. PATIENT CONCERNS: The authors describe a novel technique of lung isolation and ventilation with a Univent tube during thoracoscopic mediastinal tracheal resection and reconstruction in a female patient. DIAGNOSES: Primary tracheal adenoid cystic carcinoma, nonsmall cell carcinoma. INTERVENTIONS: In this case, tracheal resection and reconstruction were performed. A bronchial blocker of the Univent tube was used as a guide to manipulate the depth of endotracheal tube. OUTCOMES: The intermittent 1-lung ventilation was established successfully. The patient recovered uneventfully and discharged after 10 days. LESSONS: The advantages of approach include a stable airway management without occupying the contracted space of thoracoscope and no potential risk of trapping or barotraumas.
[Mh] MeSH terms primary: Airway Management/methods
Carcinoma, Adenoid Cystic/surgery
Thoracoscopy
Tracheal Neoplasms/surgery
[Mh] MeSH terms secundary: Carcinoma, Adenoid Cystic/diagnosis
Carcinoma, Adenoid Cystic/pathology
Female
Humans
Intubation, Intratracheal
Middle Aged
Tracheal Neoplasms/diagnosis
Tracheal Neoplasms/pathology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008945

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[PMID]: 29410475
[Au] Autor:Sofiev M; Winebrake JJ; Johansson L; Carr EW; Prank M; Soares J; Vira J; Kouznetsov R; Jalkanen JP; Corbett JJ
[Ad] Address:Atmospheric Composition Research, Finnish Meteorological Institute, P.O. Box 503, FI-00101, Helsinki, Finland.
[Ti] Title:Cleaner fuels for ships provide public health benefits with climate tradeoffs.
[So] Source:Nat Commun;9(1):406, 2018 02 06.
[Is] ISSN:2041-1723
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:We evaluate public health and climate impacts of low-sulphur fuels in global shipping. Using high-resolution emissions inventories, integrated atmospheric models, and health risk functions, we assess ship-related PM pollution impacts in 2020 with and without the use of low-sulphur fuels. Cleaner marine fuels will reduce ship-related premature mortality and morbidity by 34 and 54%, respectively, representing a ~ 2.6% global reduction in PM cardiovascular and lung cancer deaths and a ~3.6% global reduction in childhood asthma. Despite these reductions, low-sulphur marine fuels will still account for ~250k deaths and ~6.4 M childhood asthma cases annually, and more stringent standards beyond 2020 may provide additional health benefits. Lower sulphur fuels also reduce radiative cooling from ship aerosols by ~80%, equating to a ~3% increase in current estimates of total anthropogenic forcing. Therefore, stronger international shipping policies may need to achieve climate and health targets by jointly reducing greenhouse gases and air pollution.
[Mh] MeSH terms primary: Air Pollutants/analysis
Fossil Fuels/analysis
Models, Statistical
Particulate Matter/analysis
Public Health/trends
[Mh] MeSH terms secundary: Aerosols/analysis
Asthma/diagnosis
Asthma/economics
Asthma/etiology
Asthma/prevention & control
Cardiovascular Diseases/diagnosis
Cardiovascular Diseases/economics
Cardiovascular Diseases/etiology
Cardiovascular Diseases/prevention & control
Climate
Forecasting
Fossil Fuels/adverse effects
Fossil Fuels/supply & distribution
Humans
Lung Neoplasms/diagnosis
Lung Neoplasms/economics
Lung Neoplasms/etiology
Lung Neoplasms/prevention & control
Ships/ethics
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Aerosols); 0 (Air Pollutants); 0 (Fossil Fuels); 0 (Particulate Matter)
[Em] Entry month:1802
[Cu] Class update date: 180227
[Lr] Last revision date:180227
[Js] Journal subset:IM
[Da] Date of entry for processing:180208
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02774-9

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[PMID]: 29443771
[Au] Autor:Yanagiya M; Matsumoto J; Nagano M; Kusakabe M; Matsumoto Y; Furukawa R; Ohara S; Usui K
[Ad] Address:Department of General Thoracic Surgery, NTT Medical Center Tokyo.
[Ti] Title:Endoscopic bronchial occlusion for postoperative persistent bronchopleural fistula with computed tomography fluoroscopy guidance and virtual bronchoscopic navigation: A case report.
[So] Source:Medicine (Baltimore);97(7):e9921, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: The development of postoperative bronchopleural fistula (BPF) remains a challenge in thoracic surgery. We herein report a case of BPF successfully treated with endoscopic bronchial occlusion under computed tomography (CT) fluoroscopy and virtual bronchoscopic navigation (VBN). PATIENT CONCERNS: A 63-year-old man underwent right upper lobectomy with concomitant S6a subsegmentectomy for lung adenocarcinoma. On postoperative day 24, he complained of shaking chills with high fever. DIAGNOSES: BPF with subsequent pneumonia and empyema. INTERVENTIONS: Despite aggressive surgical interventions for the BPF, air leakage persisted postoperatively. On days 26 and 34 after the final operation, endobronchial occlusions were performed under CT fluoroscopy and VBN. OUTCOMES: The air leaks greatly decreased and the patient was discharged. LESSONS: CT fluoroscopy and VBN can be useful techniques for endobronchial occlusion in the treatment of BPF.
[Mh] MeSH terms primary: Bronchial Fistula/therapy
Bronchoscopy/methods
Fluoroscopy
Pleural Diseases/therapy
Postoperative Complications/therapy
Tomography, X-Ray Computed
[Mh] MeSH terms secundary: Adenocarcinoma/surgery
Bronchial Fistula/diagnostic imaging
Bronchial Fistula/etiology
Empyema/etiology
Humans
Lung Neoplasms/surgery
Male
Middle Aged
Pleural Diseases/diagnostic imaging
Pleural Diseases/etiology
Pneumonectomy/adverse effects
Pneumonia/etiology
Postoperative Complications/diagnostic imaging
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180220
[Lr] Last revision date:180220
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180215
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009921

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[PMID]: 29395853
[Au] Autor:Fanetti G; Bazzani F; Ferrari A; Alterio D; Donghi SM; Pounou Kamga FA; Orecchia R; Jereczek-Fossa BA
[Ad] Address:Department of Radiotherapy, European Institute of Oncology, Via Ripamonti 435, 20141 Milano, Italy; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy. Electronic address: giuseppe.fanetti@ieo.it.
[Ti] Title:Bronchiolitis obliterans organizing pneumonia after stereotactic ablative radiation therapy for lung cancer: A case report.
[So] Source:Cancer Radiother;22(1):57-61, 2018 Feb.
[Is] ISSN:1769-6658
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:Bronchiolitis obliterans organizing pneumonia is an interstitial lung disease rarely occurring after radiotherapy probably due to an activation of autoimmune processes. Most cases have been described after postoperative radiotherapy for breast cancer. Corticosteroids represent the main treatment, prognosis is generally favorable. We described a case of bronchiolitis obliterans organizing pneumonia after stereotactic ablative radiation therapy for a recurrent lung cancer. Antibiotics and steroids were administered to solve the clinical picture. After three years, a new lesion at the right lung was found and treated with stereotactic ablative radiation therapy and concomitant long course of steroids with no recurrence of bronchiolitis obliterans organizing pneumonia. Bronchiolitis obliterans organizing pneumonia is a rare event after radiotherapy with undefined risk factors. In our case, steroids played an important role in management and, maybe, in preventing bronchiolitis obliterans organizing pneumonia recurrence after second course of stereotactic ablative radiation therapy.
[Mh] MeSH terms primary: Cryptogenic Organizing Pneumonia/etiology
Lung Neoplasms/radiotherapy
Radiosurgery/adverse effects
[Mh] MeSH terms secundary: Aged
Anti-Bacterial Agents/therapeutic use
Bronchodilator Agents/therapeutic use
Carcinoma, Non-Small-Cell Lung/radiotherapy
Cryptogenic Organizing Pneumonia/drug therapy
Female
Glucocorticoids/therapeutic use
Humans
Prednisone/therapeutic use
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Anti-Bacterial Agents); 0 (Bronchodilator Agents); 0 (Glucocorticoids); VB0R961HZT (Prednisone)
[Em] Entry month:1802
[Cu] Class update date: 180220
[Lr] Last revision date:180220
[Js] Journal subset:IM
[Da] Date of entry for processing:180204
[St] Status:MEDLINE


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