Database : MEDLINE
Search on : capsule and opacification [Words]
References found : 1802 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 181 go to page                         

  1 / 1802 MEDLINE  
              next record last record
select
to print
Photocopy

[PMID]: 29516046
[Au] Autor:Iliescu IM; Constantin MA; Cozma C; Moraru OM; Moraru CM
[Ad] Address:Oculus Eye Clinic, Bucharest, Romania.
[Ti] Title:Posterior Capsule Opacification and Nd-YAG rates evaluation in a large series of pseudophakic cases.
[So] Source:Rom J Ophthalmol;61(4):267-274, 2017 Oct-Dec.
[Is] ISSN:2457-4325
[Cp] Country of publication:Romania
[La] Language:eng
[Ab] Abstract:Purpose: To evaluate the influence of Intraocular Lens (IOL) material and design on Posterior Capsule Opacification (PCO) and Neodymium-YAG (Nd-YAG) rates in eyes implanted with different Posterior Chamber Intraocular Lenses (PC IOLs) designs at the end of uncomplicated cataract surgeries. Setting: Oculus Eye Clinic, Bucharest, Romania. Design: Retrospective, observational study. Methods: This study comprised 4805 eyes operated for cataract in 2012 and 2013 with a post-operative average follow up of 40 ± 6,15 months (27-54 months). The PCO and Nd-YAG rates were recorded and compared among different IOL materials and designs and among different pathology groups. Results: From 4805 IOLs implanted, 2560 (53,27%) were hydrophilic and 2245 (45,73%) hydrophobic, 2937 (61%) were aspherical and 1868 (39%) spherical. We found statistical significant differences in the PCO and Nd-YAG rates between hydrophilic (18% and 14% respectively) and hydrophobic lenses (4% and 2% respectively) (p<0.0001). There were also statistically significant differences in the sub-group of hydrophilic aspheric IOLs, finding lower PCO and Nd:YAG rates with the C-loop haptics configuration (12,6% and 3,3% respectively) compared with the broad optic/ haptic junction (29,75% and 24,73% respectively) (p<0.001). No statistically significant differences on PCO and Nd:YAG rates were found for the different associated pathologies (p>0.05). Conclusions: Hydrophilic lenses showed statistically higher PCO and Nd:YAG rates than hydrophobic lenses. In contrast, the optic asphericity and the associated pathologies had no influence on the PCO and Nd:YAG rates. IOL design and material seem to be the main characteristics influencing PCO and Nd-YAG rates. Abbreviations: LECs = lens epithelial cells.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Process

  2 / 1802 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29344639
[Au] Autor:Feng H; Yang Z; Bai X; Yang M; Fang Y; Zhang X; Guo Q; Ning H
[Ad] Address:Department of Ophthalmology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
[Ti] Title:Therapeutic potential of a dual mTORC1/2 inhibitor for the prevention of posterior capsule opacification: An in vitro study.
[So] Source:Int J Mol Med;41(4):2099-2107, 2018 Apr.
[Is] ISSN:1791-244X
[Cp] Country of publication:Greece
[La] Language:eng
[Ab] Abstract:Mammalian target of rapamycin (mTOR) serves a central role in regulating cell growth and survival, and has been demonstrated to be involved in the pathological progression of posterior capsule opacification (PCO). In the present study, the potency of PP242, a novel dual inhibitor of mTOR complex 1/2 (mTORC1/2), in the suppression of the growth of human lens epithelial cells (HLECs) was investigated. Using a Cell Counting Kit­8 and a wound healing assay, it was demonstrated that PP242 inhibited the proliferation and migration of HLECs. In addition, western blot analysis indicated that PP242 completely inhibited mTORC1 and mTORC2 downstream signaling activities, whereas rapamycin only partially inhibited mTORC1 activity within LECs. Furthermore, PP242 treatment led to an upregulation of the expression levels of p53 and B cell lymphoma­2 (Bcl­2)­associated X and downregulation of Bcl­2. In addition, flow cytometric analysis demonstrated that PP242 induced the cell cycle arrest at the G0/G1 phase, which may have caused apoptosis and induced autophagy within the LECs. The results of the present study suggested that administration of PP242 may potentially offer a novel therapeutic approach for the prevention of PCO.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[St] Status:In-Process
[do] DOI:10.3892/ijmm.2018.3398

  3 / 1802 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29485320
[Au] Autor:Uzel MM; Ozates S; Koc M; Taslipinar Uzel AG; Yilmazbas P
[Ad] Address:a Elmadag State Hospital, Ophthalmology Department , Ankara , Turkey.
[Ti] Title:Decentration and Tilt of Intraocular Lens after Posterior Capsulotomy.
[So] Source:Semin Ophthalmol;:1-6, 2018 Feb 27.
[Is] ISSN:1744-5205
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:PURPOSE: To assess the effect of posterior capsular opacification (PCO) and Neodymium-doped:Yttrium Aluminium Garnet (Nd:YAG) laser capsulotomy on tilt and decentration of intraocular lens (IOL) at vertical and horizontal meridians. METHODS: The study included 64 eyes of 64 patients. IOL decentration and tilt were measured using a Scheimpflug camera before and 1 month after Nd:YAG capsulotomy. Corrected distance visual acuity (CDVA) and manifest refraction were also determined. Between-group differences of IOL position change and the effect of Nd:YAG laser capsulotomy were analyzed. RESULTS: In the PCO group, before capsulotomy, CDVA was significantly lower than that after capsulotomy and of the control group values (p = 0.001 for both). No significant difference was observed in CDVA between the control group and the PCO group after capsulotomy (p = 0.854). Before capsulotomy, the angle of tilt and decentration at both meridians was significantly higher than that in the control group (tilt: p < 0.001; for both decentrations: p = 0.001, p = 0.003, respectively). A significant decrease was observed in the angle of tilt at both meridians (horizontal p = 0.001, vertical p = 0.001) from before to after capsulotomy in the PCO group. Although decentration was increased after capsulotomy, no significant position change was observed (horizontal p = 0.350, vertical p = 0.107). The angle of tilt and decentration at both meridians was significantly higher in the PCO group after capsulotomy compared to the control group (p < 0.001 for all). CONCLUSIONS: PCO is associated with not only axial displacement, but also tilt and decentration of IOL at the vertical and horizontal meridians. Laser capsulotomy decreased IOL tilt but had no effect on decentration. However, these changes did not significantly change the visual acuity between the control group and the PCO group after capsulotomy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180227
[Lr] Last revision date:180227
[St] Status:Publisher
[do] DOI:10.1080/08820538.2018.1443146

  4 / 1802 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29185838
[Au] Autor:Llop SM; Papaliodis GN
[Ad] Address:a Uveitis and Ocular Immunology Service , Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School , Boston , MA , USA.
[Ti] Title:Cataract Surgery Complications in Uveitis Patients: A Review Article.
[So] Source:Semin Ophthalmol;33(1):64-69, 2018.
[Is] ISSN:1744-5205
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Uveitis is a leading causes of blindness worldwide, and the development of cataracts is common due to both the presence of intraocular inflammation and the most commonly employed treatment with corticosteroids. The management of these cataracts can be very challenging and often requires additional procedures that can compromise surgical results. The underlying disease affects a relatively young population at higher risk of complications. Preoperative control of inflammation/quiescent disease for at least three months is generally accepted as the minimum amount of time prior to surgical intervention. Phacoemulsification with intraocular lens is the preferred method for surgery, with some studies showing improvement in visual acuity in over 90% of patients. The most common postoperative complications include macular edema, posterior capsule opacification, recurrent or persistent inflammation, glaucoma, epiretinal membrane and IOL deposits, or dislocation. Despite the potential complications, cataract surgery in uveitis patients is considered a safe and successful procedure.
[Mh] MeSH terms primary: Cataract Extraction/adverse effects
Cataract/etiology
Postoperative Complications
Uveitis/complications
Visual Acuity
[Mh] MeSH terms secundary: Humans
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1802
[Cu] Class update date: 180219
[Lr] Last revision date:180219
[Js] Journal subset:IM
[Da] Date of entry for processing:171130
[St] Status:MEDLINE
[do] DOI:10.1080/08820538.2017.1353815

  5 / 1802 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29451997
[Au] Autor:Kassumeh SA; Wertheimer CM; von Studnitz A; Hillenmayer A; Priglinger C; Wolf A; Mayer WJ; Teupser D; Holdt LM; Priglinger SG; Eibl-Lindner KH
[Ad] Address:a Department of ophthalmology , Ludwig-Maximilians-University , Munich , Germany.
[Ti] Title:Poly(lactic-co-glycolic) Acid as a Slow-Release Drug-Carrying Matrix for Methotrexate Coated onto Intraocular Lenses to Conquer Posterior Capsule Opacification.
[So] Source:Curr Eye Res;:1-7, 2018 Feb 16.
[Is] ISSN:1460-2202
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:PURPOSE: Posterior capsule opacification (PCO) still represents the main long-term complication of cataract surgery. Research into pharmacologic PCO prophylaxis is extensive. One promising candidate drug is methotrexate (MTX). Our aim is to determine the in vitro feasibility of MTX-loaded poly(lactic-co-glycolic) (PLGA) biomatrices sprayed on intraocular lenses (IOLs) as a drug-delivery implant. METHODS: Hydrophilic and hydrophobic acrylic IOLs were spray-coated with MTX-loaded PLGA. Unsprayed, solvent only, and solvent-PLGA-sprayed IOLs served as controls. All IOLs were evaluated for their growth-inhibiting properties in an in vitro anterior segment model and the ex vivo human capsular bag. The release kinetics of MTX from the IOLs was determined. The toxicity of MTX on corneal endothelial cells was evaluated by using a dye reduction colorimetric assay. MTX was also used in a scratch assay. RESULTS: MTX-PLGA-IOL showed a significant difference in cell proliferation and migration compared with all controls in the anterior segment model (p < 0.001) and in the human capsular bag model (p = 0.04). No difference in viability was observed on corneal endothelial cells (p = 0.43; p = 0.61). MTX significantly inhibited cells in the scratch assay (p = 0.02). At all measured points, the released MTX dose remained above EC50 and below the toxic dose for the endothelium. CONCLUSIONS: In view of the strong inhibition of PCO in vitro with the lack of toxic effects on a corneal cell line, MTX encapsulating microspheres seem to be a promising method for modifying IOL.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[St] Status:Publisher
[do] DOI:10.1080/02713683.2018.1437455

  6 / 1802 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29283167
[Ti] Title:Erratum: Long-term results of trypan blue dye irrigation in the capsular bag to prevent posterior capsule opacification: A randomized trial.
[So] Source:Indian J Ophthalmol;66(1):181, 2018 Jan.
[Is] ISSN:1998-3689
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:[This corrects the article DOI: 10.4103/ijo.IJO_454_17.].
[Pt] Publication type:PUBLISHED ERRATUM
[Em] Entry month:1712
[Cu] Class update date: 180204
[Lr] Last revision date:180204
[St] Status:In-Data-Review
[do] DOI:10.4103/0301-4738.221858

  7 / 1802 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29324594
[Au] Autor:Fajgenbaum MAP; Neffendorf JE; Wong RS; Laidlaw DAH; Williamson TH
[Ad] Address:St. Thomas' Hospital, London, United Kingdom.
[Ti] Title:INTRAOPERATIVE AND POSTOPERATIVE COMPLICATIONS IN PHACOVITRECTOMY FOR EPIRETINAL MEMBRANE AND MACULAR HOLE: A Clinical Audit of 1000 Consecutive Eyes.
[So] Source:Retina;, 2018 Jan 10.
[Is] ISSN:1539-2864
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: The aim of this study was to report the intraoperative and postoperative complications of phacovitrectomy for epiretinal membrane (ERM) and macular hole (MH). METHODS: This was a retrospective audit of 1,052 phacovitrectomy operations (410 for ERM and 642 for MH) by the same surgical team between 1998 and 2017. Outcome measures included rates of intraoperative anterior segment and posterior segment complications such as posterior capsule rupture and retinal breaks. A subgroup analysis of 189 procedures in which postoperative complications were rigorously recorded was also undertaken. RESULTS: The rate of posterior capsule rupture was 2.2%, with no difference between ERM and MH (1.7 vs. 2.5%; P = 0.40). Iatrogenic retinal tears were more common in MH than in ERM surgery (15.6 vs. 6.8%; P < 0.001). The chance of one or more anterior segment or posterior segment intraoperative complications occurring (excluding iatrogenic retinal breaks) was not associated with: indication for surgery, grade of surgeon, gauge of surgery, surgical machine, diabetic status, patient sex, or patient age. Subgroup analysis showed postoperative events as follows: posterior capsular opacification 10.6% (20/189), posterior synechiae 4.2% (8/189), uveitis 2.1% (4/189), angle closure glaucoma 1.6% (3/189), and rhegmatogenous retinal detachment 1.1% (2/189). CONCLUSION: Phacovitrectomy seems to be safe in phakic patients with ERM or MH, performed either by fellows or consultants. It avoids the requirement for repeat surgery and is more cost and resource efficient.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180111
[Lr] Last revision date:180111
[St] Status:Publisher
[do] DOI:10.1097/IAE.0000000000002034

  8 / 1802 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29282030
[Au] Autor:MacGregor C; Jonas A; Hanifudin A; Lochhead J
[Ad] Address:Ophthalmology Department, St Mary's Hospital, Parkhurst Road, Newport, Isle of Wight, PO30 5TG, UK. macgregor.cheryl@doctors.org.uk.
[Ti] Title:Ratios for double silicone oil Endotamponade - in vitro observations may assist with ratio selection.
[So] Source:BMC Ophthalmol;17(1):264, 2017 Dec 28.
[Is] ISSN:1471-2415
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Silicone oil tamponade is more frequently reserved for cases of complex retinal detachment. We describe the effects of different variations in oil ratios with the relatively unknown technique of double oil tamponade. METHODS: Retrospective case note review of nine patients with complex rhegmatogenous retinal detachment (RD). All cases had both superior and inferior breaks, mostly with associated proliferative vitreoretinopathy (PVR). All cases were treated with pars plana vitrectomy (PPV) and a double silicone oil endotamponade (DSOE) of both heavy silicone oil and conventional 'light' silicone oil. Ratios were varied to suit different RD configurations. In vitro observations were studied to help direct these decisions. RESULTS: Anatomical success was achieved in all cases. Common complications were the same as those seen in single oil tamponade (elevated intraocular pressure, cystoid macular oedema (CMO), cataract and posterior capsule opacification. No single case of recurrent RD was seen whilst mixed oil remained in situ. CONCLUSIONS: Double silicone oil endotamponade is a safe and effective treatment for complex retinal detachments with superior and inferior breaks. Differences in oil ratios can be tailored to best fit the distribution of retinal pathology. In vitro observations may help to inform these choices.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180104
[Lr] Last revision date:180104
[St] Status:In-Process
[do] DOI:10.1186/s12886-017-0660-7

  9 / 1802 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29208832
[Au] Autor:Yadav S; Sahay P; Maharana PK; Titiyal JS; Vajpayee RB; Sharma N
[Ad] Address:Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
[Ti] Title:Comparison of visual performance and after cataract formation between two monofocal aspheric intraocular lenses following phacoemulsification for senile cataract: A randomized controlled study.
[So] Source:Indian J Ophthalmol;65(12):1445-1449, 2017 Dec.
[Is] ISSN:1998-3689
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:PURPOSE: Monofocal aspheric intraocular lenses (IOLs) provide better visual outcome compared to other available IOLs following cataract surgery. However, the imported IOLs are expensive and are not affordable by all subset of patients in low- to middle-income countries like India. The aim of this study is to compare the safety and efficacy of a relatively low cost indigenous IOL (Acriol EC) with an imported aspheric IOL (AcrySof IQ). METHODS: A randomized controlled trial was conducted at a tertiary care centre. Two hundred and five eyes of 137 patients >45 years of age with uncomplicated age-related cataract were recruited. All cases underwent standard phacoemulsification and randomly assigned to one of the IOL implantations (Group I: AcrySof IOL; Group II: Acriol EC IOL). Primary outcome measure was best-corrected visual acuity (BCVA). Secondary outcomes included visual function (VF) score, spherical equivalent, contrast sensitivity, optical aberrations, and posterior capsular opacification. Independent t-test to compare two means; Mann-Whitney test; Pearson's Chi-square test, and McNemar's test were used for analyzing the nonparametric data such as incidence of posterior capsule opacification. RESULTS: There was no significant difference in the mean postoperative BCVA at 1, 3, 6, and 12 months in either group (P > 0.05). The contrast sensitivity, wavefront aberrations, VF score, and posterior capsular opacification were comparable between the groups except for higher-order aberrations and spherical aberration, which were higher in Group II. CONCLUSIONS: Acriol EC IOL provides visual outcomes comparable to other commonly used aspheric IOLs with comparable safety and efficacy at an affordable cost.
[Mh] MeSH terms primary: Cataract/diagnosis
Contrast Sensitivity/physiology
Lenses, Intraocular
Phacoemulsification/methods
Visual Acuity/physiology
[Mh] MeSH terms secundary: Aged
Female
Follow-Up Studies
Humans
Male
Middle Aged
Perioperative Period
Prospective Studies
Prosthesis Design
Time Factors
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Entry month:1712
[Cu] Class update date: 180103
[Lr] Last revision date:180103
[Js] Journal subset:IM
[Da] Date of entry for processing:171207
[St] Status:MEDLINE
[do] DOI:10.4103/ijo.IJO_757_17

  10 / 1802 MEDLINE  
              first record previous record
select
to print
Photocopy
Full text

[PMID]: 29208831
[Au] Autor:Joshi RS; Hussain MS
[Ad] Address:Resident, Shri Vasantrao Naik Government Medical College, Yavatmal, Maharashtra, India.
[Ti] Title:Long-term results of trypan blue dye irrigation in the capsular bag to prevent posterior capsule opacification: A randomized trial.
[So] Source:Indian J Ophthalmol;65(12):1440-1444, 2017 Dec.
[Is] ISSN:1998-3689
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:PURPOSE: To study the effect of capsular bag irrigation of trypan blue dye (0.06%) on posterior capsular opacification (PCO) in eyes undergoing phacoemulsification. METHODS: This was a randomized, trial conducted at a tertiary eye care center in central India. The study included 50 patients (100 eyes) with senile cataracts who were scheduled for phacoemulsification and intraocular lens (IOL) implantation and were willing to undergo bilateral cataract surgery. One eye of each patient was randomized to one of two groups. The dye group received 0.2 ml of trypan blue injected in the capsular bag after cortical cleanup under air. The control group (other eye of the same patient) received 0.2 ml of balanced salt solution injected in a similar manner. PCO in the central 3 mm area of IOL optic was analyzed by a masked observer using an evaluation of PCO software computer analysis system at 6, 12, 24, and 36 months. RESULTS: The average age of patients was 62.05 ± 6.22 in the dye group and 64.92 ± 7.16 years in the control group. The mean PCO score at 6 months was significantly lower in the dye group (0.10 ± 0.15) than in the control group (0.22 ± 0.30). There were no significant differences in the PCO scores between the two groups from 12 to 36 months. At the end of 3 years, eight eyes in the dye group and seven in the control group required YAG capsulotomy (P = 0.21). CONCLUSION: Capsular bag irrigation of trypan blue dye decreased the PCO score at 6 months, but it had no effect at 36 months.
[Mh] MeSH terms primary: Capsule Opacification/prevention & control
Phacoemulsification/methods
Posterior Capsule of the Lens/drug effects
Postoperative Complications/prevention & control
Trypan Blue/administration & dosage
[Mh] MeSH terms secundary: Capsule Opacification/etiology
Coloring Agents/administration & dosage
Female
Follow-Up Studies
Humans
Intraoperative Period
Male
Middle Aged
Postoperative Complications/etiology
Prospective Studies
Therapeutic Irrigation
Time Factors
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; VIDEO-AUDIO MEDIA
[Nm] Name of substance:0 (Coloring Agents); I2ZWO3LS3M (Trypan Blue)
[Em] Entry month:1712
[Cu] Class update date: 180103
[Lr] Last revision date:180103
[Js] Journal subset:IM
[Da] Date of entry for processing:171207
[St] Status:MEDLINE
[do] DOI:10.4103/ijo.IJO_454_17


page 1 of 181 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information