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[PMID]: 29516422
[Au] Autor:Sarma B; Bhattacharyya PR; Bhuyan M
[Ad] Address:Academy of Scientific and Innovative Research, CSIR-NEIST Campus, Jorhat, India.
[Ti] Title:Effect of natural gas flaring upon the butterfly, Eurema hecabe (Lepidoptera: Pieridae) and its host plant, Cassia tora (Fabales: Fabaceae) in two group gathering stations of Assam, India: an approach of environmental monitoring.
[So] Source:Environ Sci Pollut Res Int;, 2018 Mar 07.
[Is] ISSN:1614-7499
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Apart from other pollutants, flaring of natural gas adds carbon dioxide into the environment and changes the atmospheric composition, including temperature and humidity. As a major gaseous product, carbon dioxide changes plant structural components as well as herbivores, i.e., insect by dilution of nitrogen under such circumstances. Present analysis demonstrated the impact of gas flaring upon adjoining biota especially Eurema hecabe butterfly and its host plant, Cassia tora in some wells (group gathering stations) of Assam, India. Analysis, pertaining from the current investigation, documented higher carbon dioxide as well as temperature in the studied flaring sites. Apart from this, reduction of leaf nitrogen, SLA, and chlorophyll with increasing in LDMC, thickness, and carbon in the studied plant as well as poor developmental rate, RGR, ECD with high RCR in insect indicated severe impact of flaring in those areas. Simulation studies with different concentration of CO in open top chamber on the plant and butterfly also revealed similar trend of results.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1007/s11356-018-1543-z

  2 / 2559 MEDLINE  
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[PMID]: 29413573
[Au] Autor:Cheng J; He S; Wan Q; Jing P
[Ad] Address:Research Center for Food Safety and Nutrition, Key Lab of Urban Agriculture (South), Bor S. Luh Food Safety Research Center, School of Agriculture & Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
[Ti] Title:Multiple fingerprinting analyses in quality control of Cassiae Semen polysaccharides.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1077-1078:22-27, 2018 Mar 01.
[Is] ISSN:1873-376X
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Quality control issue overshadows potential health benefits of Cassiae Semen due to the analytic limitations. In this study, multiple-fingerprint analysis integrated with several chemometrics was performed to assess the polysaccharide quality of Cassiae Semen harvested from different locations. FT-IR, HPLC, and GC fingerprints of polysaccharide extracts from the authentic source were established as standard profiles, applying to assess the quality of foreign sources. Analyses of FT-IR fingerprints of polysaccharide extracts using either Pearson correlation analysis or principal component analysis (PCA), or HPLC fingerprints of partially hydrolyzed polysaccharides with PCA, distinguished the foreign sources from the authentic source. However, HPLC or GC fingerprints of completely hydrolyzed polysaccharides couldn't identify all foreign sources and the methodology using GC is quite limited in determining the monosaccharide composition. This indicates that FT-IR/HPLC fingerprints of non/partially-hydrolyzed polysaccharides, respectively, accompanied by multiple chemometrics methods, might be potentially applied in detecting and differentiating sources of Cassiae Semen.
[Mh] MeSH terms primary: Cinnamomum aromaticum/chemistry
Polysaccharides/analysis
Polysaccharides/chemistry
Seeds/chemistry
[Mh] MeSH terms secundary: Chromatography, Gas
Chromatography, High Pressure Liquid
Principal Component Analysis
Spectroscopy, Fourier Transform Infrared
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Polysaccharides)
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:IM
[Da] Date of entry for processing:180208
[St] Status:MEDLINE

  3 / 2559 MEDLINE  
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[PMID]: 29501463
[Au] Autor:Yun JW; You JR; Kim YS; Kim SH; Cho EY; Yoon JH; Kwon E; Jang JJ; Park JS; Kim HC; Che JH; Kang BC
[Ad] Address:Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea.
[Ti] Title:In vitro and in vivo safety studies of cinnamon extract (Cinnamomum cassia) on general and genetic toxicology.
[So] Source:Regul Toxicol Pharmacol;, 2018 Feb 28.
[Is] ISSN:1096-0295
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Cinnamomum cassia has been widely used as a natural product to treat diseases in Asia due to its diverse pharmacological functions including anti-inflammatory, anti-oxidant, anti-microbial, anti-diabetic, and anti-tumor effects. Despite its ethnomedicinal benefits, little information regarding its toxicity is currently available. The aim of this study was to evaluate its potential long-term toxicity and genotoxicity in compliance with test guidelines of the Organization for Economic Cooperation and Development. A 13-week repeat-dose oral toxicity study revealed that body weights of rats were normal after receiving cinnamon extract at up to 2000 mg/kg. High-dose intake of cinnamon extract (2000 mg/kg) showed potential nephrotoxicity and hepatotoxicity to both males and females as evidenced by obvious increases of kidney/liver weight along with a small but statistically elevation of total cholesterol level. Overall findings from genetic toxicity testing battery including Ames test, in vitro mammalian cell micronucleus assay, and in vivo bone marrow micronucleus assay indicated that cinnamon extract was not mutagenic or clastogenic. In conclusion, cinnamon extract may possess potential nephrotoxicity and hepatotoxicity at dose higher than its recommended daily safe dose. Further study is needed to clarify the mechanism involved in its induction of liver and kidney injury.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180304
[Lr] Last revision date:180304
[St] Status:Publisher

  4 / 2559 MEDLINE  
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[PMID]: 29482462
[Au] Autor:Vijayan V; Mazumder A
[Ad] Address:a Toxicology Laboratory , Defence Research and Development Establishment , Nagpur , India.
[Ti] Title:In vitro inhibition of food borne mutagens induced mutagenicity by cinnamon (Cinnamomum cassia) bark extract.
[So] Source:Drug Chem Toxicol;:1-9, 2018 Feb 26.
[Is] ISSN:1525-6014
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Cinnamon (Cinnamomum cassia) is an important spice which is widely consumed in the Indian subcontinent as well as in several other parts of the world. In the present study, NMR spectroscopy showed the presence of cinnamaldehyde to be the major component of the bark. The possible mutagenic effects of cinnamon bark ethanolic extract (CEE, 0.01-1 mg/plate) cinnamon oil (CNO, 0.125-1 mg/plate), and its active component cinnamadehyde (CLD, 0.125-1 mg/plate) were evaluated. Antimutagenic activity of CEE, CNO, and CLD was also tested against various food borne mutagens (heterocyclic amines and aflatoxin B1 (AFB1)) and sodium azide (SA) using Ames assay. Similarly, the antimicrobial activity was studied using agar well diffusion assay against various pathogens. CEE was non-mutagenic in any of the five tester strains of Salmonella typhimurium (TA97a, TA98, TA100, TA102, and TA104) in Ames test. CEE exhibited antimutagenic activity against all the mutagens tested in the higher doses. Additionally, CEE, CNO, and CLD were effective against various pathogens such as Staphylococcus aureus, Proteus vulgaris, S. typhimurium, Klebsiella pneumoniae, and Escherichia coli in the agar well diffusion assay. Promising antimutagenic and antimicrobial properties were shown by the cinnamon bark ethanolic extract and cinnamaldehyde, respectively. Therefore, their role in cancer chemoprevention, as well as a natural antimicrobial agent must be exploited and studied in depth in in vivo conditions.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180227
[Lr] Last revision date:180227
[St] Status:Publisher
[do] DOI:10.1080/01480545.2018.1439056

  5 / 2559 MEDLINE  
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[PMID]: 29358130
[Au] Autor:Subash-Babu P; Alshatwi AA
[Ad] Address:Adipogenesis and Immunobiology Research Lab, Department of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University, Riyadh, 11451, Saudi Arabia.
[Ti] Title:Ononitol monohydrate enhances PRDM16 & UCP-1 expression, mitochondrial biogenesis and insulin sensitivity via STAT6 and LTB R in maturing adipocytes.
[So] Source:Biomed Pharmacother;99:375-383, 2018 Mar.
[Is] ISSN:1950-6007
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:Ononitol monohydrate (OMH), a glycoside was originally isolated from Cassia tora (Linn.). Glycosides regulate lipid metabolism but scientific validation desired. Hence, we aimed to evaluate the effect of OMH on enhancing mitochondrial potential, mitochondrial biogenesis, upregulate the expression of brown adipogenesis specific genes in maturing adipocytes. In addition, we observed the inter-relation between adipocyte and T-lymphocyte; whether, OMH treated adipocyte-condition medium stimulate T-cell chemokine linked with insulin resistance. In a dose dependent manner OMH treated to preadipocyte significantly inhibited maturation and enhanced mitochondrial biogenesis, it was confirmed by Oil red 'O and Nile red stain without inducing cytotoxicity. The mRNA levels of adipocyte browning related genes such as, PR domain containing 16 (PRDM16), peroxisome proliferator activated receptor gamma coactivator 1 alpha (PPARγC1α) and uncoupling protein-1 (UCP-1) have been significantly upregulated. In addition, adipogenic transcription factors [such as proliferator activated receptor γ (PPARγ), CCAAT/enhancer binding protein (C/EBPα) and sterol regulatory element binding protein-1c (SREBP-1c)] and adipogenic genes were significantly down-regulated by treatment with OMH when compared to control cells. Protein expression levels of adiponectin have been increased; leptin, C/EBPα and leukotriene B4 receptor (LTB4R) were down regulated by OMH in mature adipocytes. In addition, adipocyte condition medium and OMH treated T-lymphocyte, significantly increased insulin signaling pathway related mRNAs, such as interlukin-4 (IL-4), signal transducer and activator of transcription 6 (STAT ) and decreased leukotriene B4 (LTB ). The present findings suggest that OMH increased browning factors in differentiating and maturing preadipocyte also decreased adipose tissue inflammation as well as the enhanced insulin signaling.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180224
[Lr] Last revision date:180224
[St] Status:In-Process

  6 / 2559 MEDLINE  
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[PMID]: 29469686
[Au] Autor:Puri BK
[Ad] Address:Department of Medicine, Imperial College London, Hammersmith Hospital, London W12 0HS, England, United Kingdom.
[Ti] Title:Editorial: The Potential Medicinal Uses of Cassia tora Linn Leaf and Seed Extracts.
[So] Source:Rev Recent Clin Trials;13(1):3-4, 2018 Jan 31.
[Is] ISSN:1876-1038
[Cp] Country of publication:United Arab Emirates
[La] Language:eng
[Pt] Publication type:EDITORIAL
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[St] Status:In-Data-Review
[do] DOI:10.2174/157488711301180131145359

  7 / 2559 MEDLINE  
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[PMID]: 29463877
[Au] Autor:Yuan X; Han L; Fu P; Zeng H; Lv C; Chang W; Runyon RS; Ishii M; Han L; Liu K; Fan T; Zhang W; Liu R
[Ad] Address:School of Pharmacy, Second Military Medical University, Shanghai, 200433, P.R. China.
[Ti] Title:Cinnamaldehyde accelerates wound healing by promoting angiogenesis via up-regulation of PI3K and MAPK signaling pathways.
[So] Source:Lab Invest;, 2018 Feb 20.
[Is] ISSN:1530-0307
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The bark of Cinnamomum cassia (C. cassia) has been used for the management of coronary heart disease (CHD) and diabetes mellitus. C. cassia may target the vasculature, as it stimulates angiogenesis, promotes blood circulation and wound healing. However, the active components and working mechanisms of C. cassia are not fully elucidated. The Shexiang Baoxin pill (SBP), which consists of seven medicinal materials, including C. cassia etc., is widely used as a traditional Chinese patent medicine for the treatment of CHD. Here, 22 single effective components of SBP were evaluated against the human umbilical vein endothelial cells (HUVECs). We demonstrated that in HUVECs, cinnamaldehyde (CA) stimulated proliferation, migration, and tube formation. CA also activated the phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) pathways. Furthermore, the secretion of vascular endothelial growth factor (VEGF) from HUVECs was increased by CA. In vivo, CA partially restored intersegmental vessels in zebrafish pretreated with PTK787, which is a selective inhibitor for vascular endothelial growth factor receptor (VEGFR). CA also showed pro-angiogenic efficacy in the Matrigel plug assay. Additionally, CA attenuated wound sizes in a cutaneous wound model, and elevated VEGF protein and CD31-positive vascular density at the margin of these wounds. These results illustrate that CA accelerates wound healing by inducing angiogenesis in the wound area. The potential mechanism involves activation of the PI3K/AKT and MAPK signaling pathways. Such a small non-peptide molecule may have clinical applications for promoting therapeutic angiogenesis in chronic diabetic wounds and myocardial infarction.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180221
[Lr] Last revision date:180221
[St] Status:Publisher
[do] DOI:10.1038/s41374-018-0025-8

  8 / 2559 MEDLINE  
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[PMID]: 29442017
[Au] Autor:Vetter F; Mller C; Stckelhuber M; Bracher F
[Ti] Title:Determination of coumarin in seasonal bakery products using QuEChERS and GC-MS.
[So] Source:Pharmazie;72(6):313-316, 2017 Jun 01.
[Is] ISSN:0031-7144
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Cinnamon is a traditional herbal drug, but more importantly, it is used as a flavor compound in the production of foodstuff. Due to the content of significant concentrations of coumarin in Cassia cinnamon, effective control of the coumarin content in seasonal bakery products like ginger bread and cinnamon biscuits is urgently needed. Here we present a novel, fast and fully validated protocol for the determination of coumarin in marketed bakery products using the QuEChERS sample preparation technique in combination with GC-MS analysis. Ten grams of homogenized sample was mixed with 20 mL acetonitrile/water (1:1) and 5 g magnesium sulfate/sodium chloride mixture (4:1). The organic phase was cleaned by dSPE with 25 mg magnesium sulfate/PSA (5:1). The LOD was 0.15 g/mL and the LOQ 0.50 g/mL. We detected a mean coumarin content of 19.5 g/kg in 9 out of 14 seasonal food products (ranging from 1.45 to 39.4 mg/kg). No coumarin was detected in five cinnamon containing products. With this investigation we demonstrate that the QuEChERS sample preparation, previously applied mainly to the analysis of pesticides in vegetables, is also suitable for other complex matrices.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180214
[Lr] Last revision date:180214
[St] Status:In-Process
[do] DOI:10.1691/ph.2017.6215

  9 / 2559 MEDLINE  
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[PMID]: 29441853
[Au] Autor:Hegazi NM; Hashim AN
[Ti] Title:Grandisin, 2-methoxy 6,7,2',6'-tetrahydroxy flavanone 6- -glucoside, from leaves - antioxidant and cytotoxic activities.
[So] Source:Pharmazie;71(9):544-547, 2016 Sep 01.
[Is] ISSN:0031-7144
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Chemical investigation of Cassia grandis leaves resulted in the isolation of the new 2-methoxy 6,7,2',6'-tetrahydroxy flavanone 6-O--glucoside together with the known flavonol glycosides, kaempferol-3-O-α-rhamnoside, and quercetin 3-O-α-rhamnoside. The structure assign ments were based on conventional analytical methods and confirmed by HRFTESIMS, 1H and 13C NMR, COSY, HSQC and HMBC data. The total phenolic content of the extract was estimated by Folin-Ciocalteu's method. The antioxidant capacity was investigated using DPPH radical scavenging assay. The ethyl acetate and the n-butanol fractions showed poor cytotoxic activity only at high concentrations against the three different cancer cell lines, hepatocellular (HepG-2), breast (MCF-7), and prostate (PC3) by the neutral red uptake assay.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180214
[Lr] Last revision date:180214
[St] Status:In-Process
[do] DOI:10.1691/ph.2016.6634

  10 / 2559 MEDLINE  
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[PMID]: 29175017
[Au] Autor:Lim KT; Amanah A; Chear NJ; Zahari Z; Zainuddin Z; Adenan MI
[Ad] Address:Malaysian Institute of Pharmaceuticals and Nutraceuticals (IPharm), National Institutes of Biotechnology Malaysia, Ministry of Science, Technology and Innovation, Blok 5-A, Halaman Bukit Gambir, 11700 Penang, Malaysia.
[Ti] Title:Inhibitory effects of (+)-spectaline and iso-6-spectaline from Senna spectabilis on the growth and ultrastructure of human-infective species Trypanosoma brucei rhodesiense bloodstream form.
[So] Source:Exp Parasitol;184:57-66, 2018 Jan.
[Is] ISSN:1090-2449
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:In our ongoing work searching for new trypanocidal lead compounds from Malaysian plants, two known piperidine alkaloids (+)-spectaline (1) and iso-6-spectaline (2) were isolated from the leaves of Senna spectabilis (sin. Cassia spectabilis). Analysis of the H and C NMR spectra showed that 1 and 2 presented analytical and spectroscopic data in full agreement with those published in the literature. All compounds were screened invitro against Trypanosoma brucei rhodesiense in comparison to the standard drug pentamidine. Compound 1 and 2 inhibited growth of T.b. rhodesiense with an IC value of 0.410.01M and 0.710.01M, without toxic effect on L6 cells with associated a selectivity index of 134.92 and 123.74, respectively. These data show that piperidine alkaloids constitute a class of natural products that feature a broad spectrum of biological activities, and are potential templates for the development of new trypanocidal drugs. To our knowledge, the compounds are being reported for the first time to have inhibitory effects on T.b. rhodesiense. The ultrastructural alterations in the trypanosome induced by 1 and 2, leading to programmed cell death were characterized using electron microscopy. These alterations include wrinkling of the trypanosome surface, formation of autophagic vacuoles, disorganization of kinetoplast, and swelling of the mitochondria. These findings evidence a possible autophagic cell death.
[Mh] MeSH terms primary: Piperidines/pharmacology
Senna Plant/chemistry
Trypanocidal Agents/pharmacology
Trypanosoma brucei rhodesiense/drug effects
[Mh] MeSH terms secundary: Animals
Biological Assay
Carbon-13 Magnetic Resonance Spectroscopy
Cell Line
Humans
Inhibitory Concentration 50
Microscopy, Electron, Scanning
Microscopy, Electron, Transmission
Myoblasts, Skeletal/drug effects
Piperidines/isolation & purification
Piperidines/toxicity
Plant Extracts/isolation & purification
Plant Extracts/pharmacology
Plant Extracts/toxicity
Plant Leaves/chemistry
Proton Magnetic Resonance Spectroscopy
Rats
Senna Plant/classification
Trypanocidal Agents/isolation & purification
Trypanocidal Agents/toxicity
Trypanosoma brucei rhodesiense/growth & development
Trypanosoma brucei rhodesiense/ultrastructure
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Piperidines); 0 (Plant Extracts); 0 (Trypanocidal Agents); 0 (iso-6-spectaline); 0 (spectaline)
[Em] Entry month:1802
[Cu] Class update date: 180205
[Lr] Last revision date:180205
[Js] Journal subset:IM
[Da] Date of entry for processing:171128
[St] Status:MEDLINE


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