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[PMID]: 29455234
[Au] Autor:Wang S; Wang X; Liu M; Bai O
[Ad] Address:Department of Hematology, The First Hospital of Jilin University, No. 71 Xinmin Street, Chaoyang District, Changchun, 130021, Jilin, People's Republic of China.
[Ti] Title:Blastic plasmacytoid dendritic cell neoplasm: update on therapy especially novel agents.
[So] Source:Ann Hematol;97(4):563-572, 2018 Apr.
[Is] ISSN:1432-0584
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematopoietic malignancy mainly affecting elderly patients. Most patients present with asymptomatic skin lesions as the first symptom and has a high frequency of bone marrow involvement. BPDCN is typically characterized by CD4+ and CD 56+ co-expression without common lymphoid or myeloid lineage markers. There is no consensus on the optimal therapeutic strategy for BPDCN. It is highly responsive to chemotherapy but the median event-free survival is very short. Allogeneic stem cell transplantation may improve the prognosis of BPDCN but the rate of relapse is still high. There are no specific targeted agents approved for patients with BPDCN, but advances in the understanding of the pathobiology of BPDCN and the results of early clinical studies have revealed novel targets and potentially effective agents. Novel targeted therapies may improve outcomes for patients with BPDCN in the future.
[Mh] MeSH terms primary: Antineoplastic Agents/therapeutic use
Dendritic Cells/drug effects
Drugs, Investigational/therapeutic use
Hematologic Neoplasms/drug therapy
[Mh] MeSH terms secundary: Animals
Antineoplastic Agents/pharmacology
Antineoplastic Combined Chemotherapy Protocols/pharmacology
Antineoplastic Combined Chemotherapy Protocols/therapeutic use
Cell Line, Tumor
Central Nervous System Neoplasms/diagnosis
Central Nervous System Neoplasms/prevention & control
Central Nervous System Neoplasms/secondary
Dendritic Cells/pathology
Drugs, Investigational/pharmacology
Hematologic Neoplasms/diagnosis
Hematologic Neoplasms/pathology
Hematologic Neoplasms/surgery
Hematopoietic Stem Cell Transplantation/adverse effects
Humans
Prognosis
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Antineoplastic Agents); 0 (Drugs, Investigational)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:180219
[St] Status:MEDLINE
[do] DOI:10.1007/s00277-018-3259-z

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[PMID]: 29247857
[Au] Autor:Yin L; Li H; Liu W; Yao Z; Cheng Z; Zhang H; Zou H
[Ad] Address:Key Laboratory of Radiopharmaceuticals of Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China.
[Ti] Title:A highly potent CDK4/6 inhibitor was rationally designed to overcome blood brain barrier in gliobastoma therapy.
[So] Source:Eur J Med Chem;144:1-28, 2018 Jan 20.
[Is] ISSN:1768-3254
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:Glioblastoma multiforme (GBM) is the most common and deadliest of malignant brain tumors in adults. Disease development is associated with dysregulation of the cyclin D-CDK4/6-INK4-Rb pathway, resulting in increased proliferation; thus, CDK4/6 kinase inhibitors are promising candidates for GBM treatment. The recently developed CDK4/6 inhibitors, palbociclib, ribociclib, and abemaciclib, are effective in subcutaneous glioma models, but their blood-brain barrier (BBB) permeability is poor, limiting drug delivery to the central nervous system. Here, we designed and synthesized a series of novel CDK4/6 inhibitors with favorable BBB permeability for the treatment of GBM. Compound 11 exhibited a favorable pharmacological profile and significant penetration of the BBB with the K value of 4.10 and the K value of 0.23 in mice after an oral dose of 10 mg/kg. IC values for CDK4/cyclin D1 and CDK6/cyclin D3 were 3 nM and 1 nM, respectively. In vivo studies with an orthotopic xenograft mouse model of GBM showed that 11 had tumor growth inhibition values ranging from 62% to 99% for doses ranging from 3.125 to 50 mg/kg, and no significant body weight loss was observed. The increase in life span based on the median survival time of vehicle-treated animals in mice administered a dose of 50 mg/kg was significant at 162% (p < 0.0001). These results suggest that compound 11 is a promising candidate for further investigation as an effective drug for the treatment of GBM.
[Mh] MeSH terms primary: Brain Neoplasms/drug therapy
Cyclin-Dependent Kinase 4/antagonists & inhibitors
Cyclin-Dependent Kinase 6/antagonists & inhibitors
Drug Design
Glioblastoma/drug therapy
Protein Kinase Inhibitors/pharmacokinetics
Protein Kinase Inhibitors/therapeutic use
[Mh] MeSH terms secundary: Animals
Blood-Brain Barrier/metabolism
Blood-Brain Barrier/pathology
Brain Neoplasms/metabolism
Brain Neoplasms/pathology
Cell Line, Tumor
Cyclin-Dependent Kinase 4/metabolism
Cyclin-Dependent Kinase 6/metabolism
Dogs
Glioblastoma/metabolism
Glioblastoma/pathology
Humans
Madin Darby Canine Kidney Cells
Male
Mice
Protein Kinase Inhibitors/chemistry
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Protein Kinase Inhibitors); EC 2.7.11.22 (Cyclin-Dependent Kinase 4); EC 2.7.11.22 (Cyclin-Dependent Kinase 6)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:171217
[St] Status:MEDLINE

  3 / 28463 MEDLINE  
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[PMID]: 29521646
[Au] Autor:Velázquez Vega JE; Brat DJ
[Ad] Address:Department of Pathology and Laboratory Medicine, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA.
[Ti] Title:Incorporating Advances in Molecular Pathology Into Brain Tumor Diagnostics.
[So] Source:Adv Anat Pathol;, 2018 Mar 08.
[Is] ISSN:1533-4031
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Recent advances in molecular pathology have reshaped the practice of brain tumor diagnostics. The classification of gliomas has been restructured with the discovery of isocitrate dehydrogenase (IDH) 1/2 mutations in the vast majority of lower grade infiltrating gliomas and secondary glioblastomas (GBM), with IDH-mutant astrocytomas further characterized by TP53 and ATRX mutations. Whole-arm 1p/19q codeletion in conjunction with IDH mutations now define oligodendrogliomas, which are also enriched for CIC, FUBP1, PI3K, NOTCH1, and TERT-p mutations. IDH-wild-type (wt) infiltrating astrocytomas are mostly primary GBMs and are characterized by EGFR, PTEN, TP53, NF1, RB1, PDGFRA, and CDKN2A/B alterations, TERT-p mutations, and characteristic copy number alterations including gains of chromosome 7 and losses of 10. Other clinically and genetically distinct infiltrating astrocytomas include the aggressive H3K27M-mutant midline gliomas, and smaller subsets that occur in the setting of NF1 or have BRAF V600E mutations. Low-grade pediatric gliomas are both genetically and biologically distinct from their adult counterparts and often harbor a single driver event often involving BRAF, FGFR1, or MYB/MYBL1 genes. Large scale genomic and epigenomic analyses have identified distinct subgroups of ependymomas tightly linked to tumor location and clinical behavior. The diagnosis of embryonal neoplasms also integrates molecular testing: (I) 4 molecularly defined, biologically distinct subtypes of medulloblastomas are now recognized; (II) 3 histologic entities have now been reclassified under a diagnosis of "embryonal tumor with multilayered rosettes (ETMR), C19MC-altered"; and (III) atypical teratoid/rhabdoid tumors (AT/RT) now require SMARCB1 (INI1) or SMARCA4 (BRG1) alterations for their diagnosis. We discuss the practical use of contemporary biomarkers for an integrative diagnosis of central nervous system neoplasia.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1097/PAP.0000000000000186

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[PMID]: 29507614
[Au] Autor:Gauberti M; Fournier AP; Docagne F; Vivien D; Martinez de Lizarrondo S
[Ad] Address:Normandie Univ, UNICAEN, INSERM, INSERM UMR-S U1237, Physiopathology and Imaging for Neurological Disorders (PhIND), Cyceron, 14000 Caen, France.
[Ti] Title:Molecular Magnetic Resonance Imaging of Endothelial Activation in the Central Nervous System.
[So] Source:Theranostics;8(5):1195-1212, 2018.
[Is] ISSN:1838-7640
[Cp] Country of publication:Australia
[La] Language:eng
[Ab] Abstract:Endothelial cells of the central nervous system over-express surface proteins during neurological disorders, either as a cause, or a consequence, of the disease. Since the cerebral vasculature is easily accessible by large contrast-carrying particles, it constitutes a target of choice for molecular magnetic resonance imaging (MRI). In this review, we highlight the most recent advances in molecular MRI of brain endothelial activation and focus on the development of micro-sized particles of iron oxide (MPIO) targeting adhesion molecules including intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), P-Selectin and E-Selectin. We also discuss the perspectives and challenges for the clinical application of this technology in neurovascular disorders (ischemic stroke, intracranial hemorrhage, subarachnoid hemorrhage, diabetes mellitus), neuroinflammatory disorders (multiple sclerosis, brain infectious diseases, sepsis), neurodegenerative disorders (Alzheimer's disease, vascular dementia, aging) and brain cancers (primitive neoplasms, metastasis).
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review
[do] DOI:10.7150/thno.22662

  5 / 28463 MEDLINE  
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[PMID]: 29382830
[Au] Autor:Aramillo Irizar P; Schäuble S; Esser D; Groth M; Frahm C; Priebe S; Baumgart M; Hartmann N; Marthandan S; Menzel U; Müller J; Schmidt S; Ast V; Caliebe A; König R; Krawczak M; Ristow M; Schuster S; Cellerino A; Diekmann S; Englert C; Hemmerich P; Sühnel J; Guthke R; Witte OW; Platzer M; Ruppin E; Kaleta C
[Ad] Address:Research Group Medical Systems Biology, Institute of Experimental Medicine, Christian-Albrechts-University Kiel, D-24105, Kiel, Germany.
[Ti] Title:Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly.
[So] Source:Nat Commun;9(1):327, 2018 01 30.
[Is] ISSN:2041-1723
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Disease epidemiology during ageing shows a transition from cancer to degenerative chronic disorders as dominant contributors to mortality in the old. Nevertheless, it has remained unclear to what extent molecular signatures of ageing reflect this phenomenon. Here we report on the identification of a conserved transcriptomic signature of ageing based on gene expression data from four vertebrate species across four tissues. We find that ageing-associated transcriptomic changes follow trajectories similar to the transcriptional alterations observed in degenerative ageing diseases but are in opposite direction to the transcriptomic alterations observed in cancer. We confirm the existence of a similar antagonism on the genomic level, where a majority of shared risk alleles which increase the risk of cancer decrease the risk of chronic degenerative disorders and vice versa. These results reveal a fundamental trade-off between cancer and degenerative ageing diseases that sheds light on the pronounced shift in their epidemiology during ageing.
[Mh] MeSH terms primary: Aging/genetics
Cardiovascular Diseases/genetics
Diabetes Mellitus/genetics
Neoplasms/genetics
Neurodegenerative Diseases/genetics
Transcriptome
[Mh] MeSH terms secundary: Adolescent
Adult
Aged
Aged, 80 and over
Aging/metabolism
Aging/pathology
Animals
Brain/growth & development
Brain/metabolism
Cardiovascular Diseases/blood
Cardiovascular Diseases/pathology
Child
Child, Preschool
Chronic Disease
Diabetes Mellitus/blood
Diabetes Mellitus/pathology
Fundulidae/genetics
Fundulidae/growth & development
Fundulidae/metabolism
Gene Ontology
Genome, Human
Humans
Infant
Liver/growth & development
Liver/metabolism
Mice
Middle Aged
Molecular Sequence Annotation
Neoplasms/metabolism
Neoplasms/pathology
Neurodegenerative Diseases/blood
Neurodegenerative Diseases/pathology
Skin/growth & development
Skin/metabolism
Zebrafish/genetics
Zebrafish/growth & development
Zebrafish/metabolism
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[Js] Journal subset:IM
[Da] Date of entry for processing:180201
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02395-2

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[PMID]: 28746860
[Au] Autor:Rogawski DS; Vitanza NA; Gauthier AC; Ramaswamy V; Koschmann C
[Ad] Address:Department of Pediatrics, University of Michigan School of Medicine, Ann Arbor, Mich.
[Ti] Title:Integrating RNA sequencing into neuro-oncology practice.
[So] Source:Transl Res;189:93-104, 2017 Nov.
[Is] ISSN:1878-1810
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Malignant tumors of the central nervous system (CNS) cause substantial morbidity and mortality, yet efforts to optimize chemo- and radiotherapy have largely failed to improve dismal prognoses. Over the past decade, RNA sequencing (RNA-seq) has emerged as a powerful tool to comprehensively characterize the transcriptome of CNS tumor cells in one high-throughput step, leading to improved understanding of CNS tumor biology and suggesting new routes for targeted therapies. RNA-seq has been instrumental in improving the diagnostic classification of brain tumors, characterizing oncogenic fusion genes, and shedding light on intratumor heterogeneity. Currently, RNA-seq is beginning to be incorporated into regular neuro-oncology practice in the form of precision neuro-oncology programs, which use information from tumor sequencing to guide implementation of personalized targeted therapies. These programs show great promise in improving patient outcomes for tumors where single agent trials have been ineffective. As RNA-seq is a relatively new technique, many further applications yielding new advances in CNS tumor research and management are expected in the coming years.
[Mh] MeSH terms primary: Medical Oncology
Nervous System Neoplasms/genetics
Sequence Analysis, RNA/methods
[Mh] MeSH terms secundary: Gene Expression Regulation, Neoplastic
Humans
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1711
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:170727
[St] Status:MEDLINE

  7 / 28463 MEDLINE  
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[PMID]: 29480846
[Au] Autor:Cai J; Li W; Du J; Xu N; Gao P; Zhou J; Li X
[Ad] Address:Department of Radiology, Beijing Tiantan Hospital affiliated to Capital Medical University.
[Ti] Title:Supratentorial intracerebral cerebellar liponeurocytoma: A case report and literature review.
[So] Source:Medicine (Baltimore);97(2):e9556, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Cerebellar liponeurocytoma is a rare tumor of the central nervous system (CNS) characterized by low proliferation but high likelihood of recurrence. Because of its rarity and the paucity of systematic follow-up, the biological behaviors and clinical features of this tumor are still poorly understood. We herein reported a case of cerebellar liponeurocytoma originating in the cerebral hemisphere. PATIENT CONCERNS: A 11-year-old male with intermittent headache, nausea, and vomiting. The first computed tomography revealed a large mass in the right cerebral hemisphere. He was transferred to our institution for neurosurgical treatment. DIAGNOSIS: Magnetic resonance imaging showed a large cystic-solid mass in the right frontal lobe with obvious contrast enhancement. Histopathological examinations showed sheets of isomorphic small neoplastic cells with clear cytoplasm and focal lipomatous differentiation. On immunohistochemistry, tumor cells were positive for synaptophysin, microtubule-associated protein 2, and neuronal nuclei antigen. INTERVENTIONS: The patient was performed a right fronto-parietal craniotomy, and gross total resection of the tumor was achieved without adjuvant therapy. OUTCOMES: No clinical or neuroradiological evidence of recurrence or residual of the tumor was found 6 years and 2 months after initial surgery. LESSONS: Cerebellar liponeurocytoma developing in supratentorial cerebral hemisphere was first reported in the present study. The radiological and histopathological features may be useful in differentiating this rare tumor from other tumors at similar locations. A change in the nomenclature of cerebellar liponeurocytomas should be considered in future World Health Organization (WHO) classifications.
[Mh] MeSH terms primary: Cerebellar Neoplasms/diagnostic imaging
Cerebellar Neoplasms/surgery
Neurocytoma/diagnostic imaging
Neurocytoma/surgery
Supratentorial Neoplasms/diagnostic imaging
Supratentorial Neoplasms/surgery
[Mh] MeSH terms secundary: Cerebellar Neoplasms/pathology
Child
Diagnosis, Differential
Humans
Male
Neurocytoma/pathology
Supratentorial Neoplasms/pathology
Terminology as Topic
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180227
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009556

  8 / 28463 MEDLINE  
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[PMID]: 28451716
[Au] Autor:Mayer C; Hattingen E; Schild H; Bootz F; Schröck A
[Ad] Address:Klinik für Radiologie, Universität Bonn, Bonn, Deutschland.
[Ti] Title:Interventionelle Radiologie im Kopf-Hals-Bereich. [Interventional radiology in the head and neck region].
[So] Source:HNO;65(6):482-489, 2017 Jun.
[Is] ISSN:1433-0458
[Cp] Country of publication:Germany
[La] Language:ger
[Ab] Abstract:In interventional neuroradiology, endovascular embolization represents an important and helpful tool in the treatment of multiple head and neck diseases. These interventional procedures may be performed with curative intent, to reduce the surgical risk within a multimodal treatment concept, or to improve or at least maintain a good quality of life within a palliative therapy concept. In addition to a good understanding of disease pathology, knowledge of vascular anatomy, including collateral vessels and dangerous extracranial-intracranial anastomoses, is essential for successful treatment, as is implementation of an established technique using appropriate material. Indications for endovascular embolization are i. otherwise unmanageable bleeding (caused by e. g., trauma, vascular malformation, or tumor), ii. reduction of perioperative bleeding by preoperative embolization in case of a hypervascularized tumor, iii. selective induction of tumor necrosis by palliative embolization to enhance local tumor control. Major complications such as stroke, loss of vision, and cranial nerve palsy are mostly due to a lack of preinterventional evaluation. Regarding neurological deficits, interventions within the supply region of the external carotid artery have a complication rate below 1%.
[Mh] MeSH terms primary: Central Nervous System Vascular Malformations/diagnostic imaging
Central Nervous System Vascular Malformations/therapy
Embolization, Therapeutic/methods
Head and Neck Neoplasms/diagnostic imaging
Head and Neck Neoplasms/therapy
Hemostatics/therapeutic use
Radiography, Interventional/methods
[Mh] MeSH terms secundary: Evidence-Based Medicine
Head/blood supply
Head/diagnostic imaging
Humans
Neck/blood supply
Neck/diagnostic imaging
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Hemostatics)
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:IM
[Da] Date of entry for processing:170429
[St] Status:MEDLINE
[do] DOI:10.1007/s00106-017-0354-8

  9 / 28463 MEDLINE  
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[PMID]: 29502353
[Au] Autor:Prabhakaran N; Guzman MA; Navalkele P; Chow-Maneval E; Batanian JR
[Ad] Address:Department of Pathology, University of Missouri School of Medicine, Columbia, Missouri, USA.
[Ti] Title:Novel TLE4-NTRK2 fusion in a ganglioglioma identified by array-CGH and confirmed by NGS: Potential for a gene targeted therapy.
[So] Source:Neuropathology;, 2018 Mar 04.
[Is] ISSN:1440-1789
[Cp] Country of publication:Australia
[La] Language:eng
[Ab] Abstract:Gangliogliomas are rare neoplasms of the central nervous system that mostly originate in the temporal lobe and are associated with seizures. Literature mentions that BRAF mutations are most commonly associated with gangliogliomas. We discuss a unique case of ganglioglioma originating in the posterior fossa that showed multiple losses and a unique interstitial deletion at 9q21 by an array-comparative genome hybridization (array-CGH). The deletion led to a novel molecular fusion (TLE4-NTRK2) which was confirmed by next generation sequencing and provides a potential for a gene-targeted therapy.
[Pt] Publication type:CASE REPORTS
[Em] Entry month:1803
[Cu] Class update date: 180304
[Lr] Last revision date:180304
[St] Status:Publisher
[do] DOI:10.1111/neup.12458

  10 / 28463 MEDLINE  
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[PMID]: 29499085
[Au] Autor:Zureick AH; Evans CL; Niemierko A; Grieco JA; Nichols AJ; Fullerton BC; Hess CB; Goebel CP; Gallotto SL; Weyman EA; Gaudet DE; Nartowicz JA; Ebb DH; Jones RM; MacDonald SM; Tarbell NJ; Yock TI; Pulsifer MB
[Ad] Address:Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts.
[Ti] Title:Left hippocampal dosimetry correlates with visual and verbal memory outcomes in survivors of pediatric brain tumors.
[So] Source:Cancer;, 2018 Mar 02.
[Is] ISSN:1097-0142
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Radiotherapy (RT) in the pediatric brain tumor population causes late neurocognitive effects. In the current study, the authors investigated associations between clinical and dosimetric risk factors and memory outcomes in a cohort of patients treated with proton radiotherapy (PRT). METHODS: A total of 70 patients (median age at PRT, 12.1 years [range, 5.0-22.5 years]) who were treated with PRT were identified with baseline and follow-up evaluations of visual and verbal memory (Children's Memory Scale and the third edition of the Wechsler Memory Scale). Whole-brain as well as bilateral hippocampal and temporal lobe contours were delineated for the calculation of dosimetric indices. Multivariate analyses were performed to assess associations of score changes over time with clinical factors and dosimetric indices. RESULTS: The median neurocognitive follow-up was 3.0 years (range, 1.1-11.4 years). For the entire cohort, delayed and immediate verbal memory scaled scores demonstrated small declines. The mean decline for delayed verbal memory scores was 0.6 (P = .01), and that for immediate verbal memory scores was 0.5 (P = .06). Immediate and delayed visual memory scores were not found to change significantly (+0.1 and -0.3, respectively; P>.30). A higher left hippocampal V (percentage of the volume of a particular anatomical region receiving at least a 20 gray equivalent) was correlated with a score decline in all 4 measures. Female sex was found to be predictive of lower delayed verbal memory follow-up scores (P = .035). CONCLUSIONS: Only delayed verbal memory scores were found to have declined statistically significantly at follow-up after PRT, reflecting some weakness in verbal memory retrieval. Given a correlation of left hippocampal dosimetry and memory outcomes after PRT, left hippocampal-sparing PRT plans may assist patients with pediatric brain tumors in preserving memory-retrieval abilities. Cancer 2018. © 2018 American Cancer Society.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:Publisher
[do] DOI:10.1002/cncr.31143


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