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Search on : chromaffin and system [Words]
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[PMID]: 29406048
[Au] Autor:Chaaya G; Morales J; Castiglioni A; Subhani N; Asmar A
[Ad] Address:University of Central Florida College of Medicine, Orlando, Florida.
[Ti] Title:Paraganglioma of the Urinary Bladder: A Rare Cause of Hypertension and Urinary Tract Infections.
[So] Source:Am J Med Sci;355(2):191-194, 2018 Feb.
[Is] ISSN:1538-2990
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Pheochromocytoma is a neoplasm, which develops from cells of the chromaffin tissues that are derived from the ectodermic neural system and mostly situated within the adrenal medulla. Approximately 15% of pheochromocytoma cases arise from extra-adrenal chromaffin tissue. Pheochromocytoma of the bladder is rare and accounts for less than 0.06% of all bladder neoplasms and less than 1% of all pheochromocytomas. We report a case of a young woman who presented with uncontrolled hypertension, recurrent urinary tract infections and micturition attacks and was found to have a metastatic bladder paraganglioma. In addition, we provide a summary table of the clinical manifestations of paragangliomas based on anatomic locations.
[Mh] MeSH terms primary: Adrenal Gland Neoplasms
Hypertension
Urinary Bladder Neoplasms
Urinary Tract Infections
[Mh] MeSH terms secundary: Adrenal Gland Neoplasms/microbiology
Adrenal Gland Neoplasms/pathology
Adrenal Gland Neoplasms/physiopathology
Adult
Female
Humans
Hypertension/microbiology
Hypertension/pathology
Hypertension/physiopathology
Neoplasm Metastasis
Pheochromocytoma/microbiology
Pheochromocytoma/pathology
Pheochromocytoma/physiopathology
Pheochromocytoma/secondary
Urinary Bladder Neoplasms/microbiology
Urinary Bladder Neoplasms/pathology
Urinary Bladder Neoplasms/physiopathology
Urinary Tract Infections/microbiology
Urinary Tract Infections/pathology
Urinary Tract Infections/physiopathology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180207
[St] Status:MEDLINE

  2 / 4609 MEDLINE  
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[PMID]: 27770433
[Au] Autor:Jenkins DE; Sreenivasan D; Carman F; Samal B; Eiden LE; Bunn SJ
[Ad] Address:Department of Anatomy, Centre for Neuroendocrinology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand.
[Ti] Title:Interleukin-6-mediated signaling in adrenal medullary chromaffin cells.
[So] Source:J Neurochem;139(6):1138-1150, 2016 12.
[Is] ISSN:1471-4159
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The pro-inflammatory cytokines, tumor necrosis factor-α, and interleukin-1ß/α modulate catecholamine secretion, and long-term gene regulation, in chromaffin cells of the adrenal medulla. Since interleukin-6 (IL6) also plays a key integrative role during inflammation, we have examined its ability to affect both tyrosine hydroxylase activity and adrenomedullary gene transcription in cultured bovine chromaffin cells. IL6 caused acute tyrosine/threonine phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2), and serine/tyrosine phosphorylation of signal transducer and activator of transcription 3 (STAT3). Consistent with ERK1/2 activation, IL6 rapidly increased tyrosine hydroxylase phosphorylation (serine-31) and activity, as well as up-regulated genes, encoding secreted proteins including galanin, vasoactive intestinal peptide, gastrin-releasing peptide, and parathyroid hormone-like hormone. The effects of IL6 on the entire bovine chromaffin cell transcriptome were compared to those generated by G-protein-coupled receptor (GPCR) agonists (histamine and pituitary adenylate cyclase-activating polypeptide) and the cytokine receptor agonists (interferon-α and tumor necrosis factor-α). Of 90 genes up-regulated by IL6, only 16 are known targets of IL6 in the immune system. Those remaining likely represent a combination of novel IL6/STAT3 targets, ERK1/2 targets and, potentially, IL6-dependent genes activated by IL6-induced transcription factors, such as hypoxia-inducible factor 1α. Notably, genes induced by IL6 include both neuroendocrine-specific genes activated by GPCR agonists, and transcripts also activated by the cytokines. These results suggest an integrative role for IL6 in the fine-tuning of the chromaffin cell response to a wide range of physiological and paraphysiological stressors, particularly when immune and endocrine stimuli converge.
[Mh] MeSH terms primary: Adrenal Medulla/metabolism
Chromaffin Cells/metabolism
Interleukin-6/physiology
MAP Kinase Signaling System/physiology
[Mh] MeSH terms secundary: Adrenal Medulla/cytology
Adrenal Medulla/drug effects
Animals
Cattle
Cells, Cultured
Chromaffin Cells/drug effects
Interleukin-6/pharmacology
MAP Kinase Signaling System/drug effects
STAT3 Transcription Factor/metabolism
Signal Transduction/drug effects
Signal Transduction/physiology
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., INTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Interleukin-6); 0 (STAT3 Transcription Factor)
[Em] Entry month:1706
[Cu] Class update date: 180124
[Lr] Last revision date:180124
[Js] Journal subset:IM
[Da] Date of entry for processing:161023
[St] Status:MEDLINE
[do] DOI:10.1111/jnc.13870

  3 / 4609 MEDLINE  
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[PMID]: 29211994
[Au] Autor:Wu XS; Elias S; Liu H; Heureaux J; Wen PJ; Liu AP; Kozlov MM; Wu LG
[Ad] Address:National Institute of Neurological Disorders and Stroke, Bethesda, Maryland.
[Ti] Title:Membrane Tension Inhibits Rapid and Slow Endocytosis in Secretory Cells.
[So] Source:Biophys J;113(11):2406-2414, 2017 Dec 05.
[Is] ISSN:1542-0086
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Endocytosis generates spherical or ellipsoid-like vesicles from the plasma membrane, which recycles vesicles that fuse with the plasma member during exocytosis in neurons and endocrine secretory cells. Although tension in the plasma membrane is generally considered to be an important factor in regulating endocytosis, whether membrane tension inhibits or facilitates endocytosis remains debated in the endocytosis field, and has been rarely studied for vesicular endocytosis in secretory cells. Here we report that increasing membrane tension by adjusting osmolarity inhibited both the rapid (a few seconds) and slow (tens of seconds) endocytosis in calyx-type nerve terminals containing conventional active zones and in neuroendocrine chromaffin cells. We address the mechanism of this phenomenon by computational modeling of the energy barrier that the system must overcome at the stage of membrane budding by an assembling protein coat. We show that this barrier grows with increasing tension, which may slow down or prevent membrane budding. These results suggest that in live secretory cells, membrane tension exerts inhibitory action on endocytosis.
[Mh] MeSH terms primary: Cell Membrane/metabolism
Chromaffin Cells/cytology
Chromaffin Cells/metabolism
Endocytosis
[Mh] MeSH terms secundary: Animals
Female
Intracellular Space/metabolism
Kinetics
Male
Mice
Osmolar Concentration
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180119
[Lr] Last revision date:180119
[Js] Journal subset:IM
[Da] Date of entry for processing:171207
[St] Status:MEDLINE

  4 / 4609 MEDLINE  
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[PMID]: 29255564
[Au] Autor:Kapetanakis S; Chourmouzi D; Gkasdaris G; Katsaridis V; Eleftheriadis E; Givissis P
[Ad] Address:Spine Department and Deformities, Interbalkan European Medical Center, Thessaloniki, Greece.
[Ti] Title:Functional extra-adrenal paraganglioma of the retroperitoneum giving thoracolumbar spine metastases after a five-year disease-free follow-up: a rare malignant condition with challenging management.
[So] Source:Pan Afr Med J;28:94, 2017.
[Is] ISSN:1937-8688
[Cp] Country of publication:Uganda
[La] Language:eng
[Ab] Abstract:Paragangliomas are benign neoplasms that arise from the autonomic nervous system and the associated paraganglia. Although benign, they have been shown to possess metastatic potential. Extra-adrenal retroperitoneal paraganglioma with vertebral metastasis is considered very uncommon. Here, we present a case of a functional extra-adrenal paraganglioma of the retroperitoneum giving metastasis to T4 vertebra after five years of follow-up in a 48-year-old man who had been initially treated with complete resection of the primary tumor. The condition of the patient improved significantly after radiosurgery and somatostatin analogs treatment, until lumbar spine lesions appeared six months later. Our case demonstrates that retroperitoneal paraganglioma is a rare condition which should be considered in the differential diagnosis of a retroperitoneal mass combined with vertebral lesions. Additionally, increased physician awareness and long-term follow-up is mandatory for all patients with history of retroperitoneal paraganglioma since metastases may occur after long latent intervals from the initial diagnosis.
[Mh] MeSH terms primary: Paraganglioma, Extra-Adrenal/pathology
Retroperitoneal Neoplasms/pathology
Spinal Neoplasms/secondary
[Mh] MeSH terms secundary: Follow-Up Studies
Humans
Lumbar Vertebrae
Male
Middle Aged
Paraganglioma, Extra-Adrenal/surgery
Retroperitoneal Neoplasms/surgery
Spinal Neoplasms/pathology
Spinal Neoplasms/therapy
Thoracic Vertebrae
Time Factors
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171222
[Lr] Last revision date:171222
[Js] Journal subset:IM
[Da] Date of entry for processing:171220
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.28.94.13783

  5 / 4609 MEDLINE  
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[PMID]: 29058015
[Au] Autor:Becker J; Wilting J
[Ad] Address:Institute of Anatomy and Cell Biology, University Medical School Göttingen, 37075, Göttingen, Germany. juergen.becker@med.uni-goettingen.de.
[Ti] Title:WNT signaling, the development of the sympathoadrenal-paraganglionic system and neuroblastoma.
[So] Source:Cell Mol Life Sci;, 2017 Oct 22.
[Is] ISSN:1420-9071
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Neuroblastoma (NB) is a tumor of the sympathoadrenal system arising in children under 15 years of age. In Germany, NB accounts for 7% of childhood cancer cases, but 11% of cancer deaths. It originates from highly migratory progenitor cells that leave the dorsal neural tube and contribute neurons and glial cells to sympathetic ganglia, and chromaffin and supportive cells to the adrenal medulla and paraganglia. Clinically, histologically and molecularly, NBs present as extremely heterogeneous, ranging from very good to very poor prognosis. The etiology of NB still remains unclear and needs to be elucidated, however, aberrant auto- and paracrine embryonic cell communications seem to be likely candidates to initiate or facilitate the emergence, progression and regression of NB. The wingless-type MMTV integration site (WNT) family of proteins represents an evolutionary highly conserved signaling system that orchestrates embryogenesis. At least 19 ligands in the human, numerous receptors and co-receptors are known, which control not only proliferation, but also cell polarity, migration and differentiation. Here we seek to interconnect aspects of WNT signaling with sympathoadrenal and paraganglionic development to define new WNT signaling cues in the etiology and progression of NB.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1710
[Cu] Class update date: 171023
[Lr] Last revision date:171023
[St] Status:Publisher
[do] DOI:10.1007/s00018-017-2685-8

  6 / 4609 MEDLINE  
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[PMID]: 29052004
[Au] Autor:Nurse CA; Salman S; Scott AL
[Ad] Address:Department of Biology and Molecular Medicine, McMaster University, 1280 Main St. West, Hamilton, ON, L8S 4K1, Canada. nursec@mcmaster.ca.
[Ti] Title:Hypoxia-regulated catecholamine secretion in chromaffin cells.
[So] Source:Cell Tissue Res;, 2017 Oct 19.
[Is] ISSN:1432-0878
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Adrenal catecholamine (CAT) secretion is a general physiological response of animals to environmental stressors such as hypoxia. This represents an important adaptive mechanism to maintain homeostasis and protect vital organs such as the brain. In adult mammals, CAT secretory responses are triggered by activation of the sympathetic nervous system that supplies cholinergic innervation of adrenomedullary chromaffin cells (AMC) via the splanchnic nerve. In the neonate, the splanchnic innervation of AMC is immature or absent, yet hypoxia stimulates a non-neurogenic CAT secretion that is critical for adaptation to extra-uterine life. This non-neurogenic, hypoxia-sensing mechanism in AMC is gradually lost or suppressed postnatally along a time course that parallels the development of splanchnic innervation. Moreover, denervation of adult AMC results in a gradual return of the direct hypoxia-sensing mechanism. The signaling pathways by which neonatal AMC sense acute hypoxia leading to non-neurogenic CAT secretion and the mechanisms that underlie the re-acquisition of hypoxia-sensing properties by denervated adult AMC, are beginning to be understood. This review will focus on current views concerning the mechanisms responsible for direct acute hypoxia sensing and CAT secretion in perinatal AMC and how they are regulated by innervation during postnatal development. It will also briefly discuss plasticity mechanisms likely to contribute to CAT secretion during exposures to chronic and intermittent hypoxia.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1710
[Cu] Class update date: 171020
[Lr] Last revision date:171020
[St] Status:Publisher
[do] DOI:10.1007/s00441-017-2703-z

  7 / 4609 MEDLINE  
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[PMID]: 29027927
[Au] Autor:Ramírez D; Gonzalez W; Fissore RA; Carvacho I
[Ad] Address:Centro de Bioinformática y Simulación Molecular, Universidad de Talca, 3460000 Talca, Chile. davramirez@utalca.cl.
[Ti] Title:Conotoxins as Tools to Understand the Physiological Function of Voltage-Gated Calcium (Ca ) Channels.
[So] Source:Mar Drugs;15(10), 2017 Oct 13.
[Is] ISSN:1660-3397
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Voltage-gated calcium (Ca ) channels are widely expressed and are essential for the completion of multiple physiological processes. Close regulation of their activity by specific inhibitors and agonists become fundamental to understand their role in cellular homeostasis as well as in human tissues and organs. Ca channels are divided into two groups depending on the membrane potential required to activate them: High-voltage activated (HVA, Ca 1.1-1.4; Ca 2.1-2.3) and Low-voltage activated (LVA, Ca 3.1-3.3). HVA channels are highly expressed in brain (neurons), heart, and adrenal medulla (chromaffin cells), among others, and are also classified into subtypes which can be distinguished using pharmacological approaches. Cone snails are marine gastropods that capture their prey by injecting venom, "conopeptides", which cause paralysis in a few seconds. A subset of conopeptides called conotoxins are relatively small polypeptides, rich in disulfide bonds, that target ion channels, transporters and receptors localized at the neuromuscular system of the animal target. In this review, we describe the structure and properties of conotoxins that selectively block HVA calcium channels. We compare their potency on several HVA channel subtypes, emphasizing neuronal calcium channels. Lastly, we analyze recent advances in the therapeutic use of conotoxins for medical treatments.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1710
[Cu] Class update date: 171110
[Lr] Last revision date:171110
[St] Status:In-Process

  8 / 4609 MEDLINE  
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[PMID]: 28971249
[Au] Autor:Chan WH; Anderson CR; Gonsalvez DG
[Ad] Address:Department of Anatomy and Neuroscience, School of Biomedical Sciences, The University of Melbourne, Parkville, 3010, Australia.
[Ti] Title:From proliferation to target innervation: signaling molecules that direct sympathetic nervous system development.
[So] Source:Cell Tissue Res;, 2017 Oct 02.
[Is] ISSN:1432-0878
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:The sympathetic division of the autonomic nervous system includes a variety of cells including neurons, endocrine cells and glial cells. A recent study (Furlan et al. 2017) has revised thinking about the developmental origin of these cells. It now appears that sympathetic neurons and chromaffin cells of the adrenal medulla do not have an immediate common ancestor in the form a "sympathoadrenal cell", as has been long believed. Instead, chromaffin cells arise from Schwann cell precursors. This review integrates the new findings with the expanding body of knowledge on the signalling pathways and transcription factors that regulate the origin of cells of the sympathetic division of the autonomic nervous system.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1710
[Cu] Class update date: 171003
[Lr] Last revision date:171003
[St] Status:Publisher
[do] DOI:10.1007/s00441-017-2693-x

  9 / 4609 MEDLINE  
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[PMID]: 28965274
[Au] Autor:Eiden LE; Emery AC; Zhang L; Smith CB
[Ad] Address:Section on Molecular Neuroscience, National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA. eidenl@mail.nih.gov.
[Ti] Title:PACAP signaling in stress: insights from the chromaffin cell.
[So] Source:Pflugers Arch;, 2017 Sep 30.
[Is] ISSN:1432-2013
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Pituitary adenylate cyclase-activating polypeptide (PACAP) was first identified in hypothalamus, based on its ability to elevate cyclic AMP in the anterior pituitary. PACAP has been identified as the adrenomedullary neurotransmitter in stress through a combination of ex vivo, in vivo, and in cellula experiments over the past two decades. PACAP causes catecholamine secretion, and activation of catecholamine biosynthetic enzymes, during episodes of stress in mammals. Features of PACAP signaling allowing stress transduction at the splanchnicoadrenomedullary synapse have yielded insights into the contrasting roles of acetylcholine's and PACAP's actions as first messengers at the chromaffin cell, via differential release at low and high rates of splanchnic nerve firing, and differential signaling pathway engagement leading to catecholamine secretion and chromaffin cell gene transcription. Secretion stimulated by PACAP, via calcium influx independent of action potential generation, is under active investigation in several laboratories both at the chromaffin cell and within autonomic ganglia of both the parasympathetic and sympathetic nervous systems. PACAP is a neurotransmitter important in stress transduction in the central nervous system as well, and is found at stress-transduction nuclei in brain including the paraventricular nucleus of hypothalamus, the amygdala and extended amygdalar nuclei, and the prefrontal cortex. The current status of PACAP as a master regulator of stress signaling in the nervous system derives fundamentally from the establishment of its role as the splanchnicoadrenomedullary transmitter in stress. Experimental elucidation of PACAP action at this synapse remains at the forefront of understanding PACAP's role in stress signaling throughout the nervous system.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1710
[Cu] Class update date: 171001
[Lr] Last revision date:171001
[St] Status:Publisher
[do] DOI:10.1007/s00424-017-2062-3

  10 / 4609 MEDLINE  
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[PMID]: 28887593
[Au] Autor:Dhara M; Mohrmann R; Bruns D
[Ad] Address:Molecular Neurophysiology, CIPMM, Medical Faculty, Saarland University, 66421, Homburg/Saar, Germany.
[Ti] Title:v-SNARE function in chromaffin cells.
[So] Source:Pflugers Arch;, 2017 Sep 08.
[Is] ISSN:1432-2013
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Vesicle fusion is elementary for intracellular trafficking and release of signal molecules, thus providing the basis for diverse forms of intercellular communication like hormonal regulation or synaptic transmission. A detailed characterization of the mechanisms underlying exocytosis is key to understand how the nervous system integrates information and generates appropriate responses to stimuli. The machinery for vesicular release employs common molecular players in different model systems including neuronal and neuroendocrine cells, in particular members of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) protein family, Sec1/Munc18-like proteins, and other accessory factors. To achieve temporal precision and speed, excitable cells utilize specialized regulatory proteins like synaptotagmin and complexin, whose interplay putatively synchronizes vesicle fusion and enhances stimulus-secretion coupling. In this review, we aim to highlight recent progress and emerging views on the molecular mechanisms, by which constitutively forming SNAREpins are organized in functional, tightly regulated units for synchronized release. Specifically, we will focus on the role of vesicle associated membrane proteins, also referred to as vesicular SNAREs, in fusion and rapid cargo discharge. We will further discuss the functions of SNARE regulators during exocytosis and focus on chromaffin cell as a model system of choice that allows for detailed structure-function analyses and direct measurements of vesicle fusion under precise control of intracellular [Ca]i.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1709
[Cu] Class update date: 170909
[Lr] Last revision date:170909
[St] Status:Publisher
[do] DOI:10.1007/s00424-017-2066-z


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