Database : MEDLINE
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[PMID]: 28461004
[Au] Autor:Stevanovic K; Yunus A; Joly-Amado A; Gordon M; Morgan D; Gulick D; Gamsby J
[Ad] Address:Department of Molecular Medicine, University of South Florida, Tampa, FL, USA; Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA. Electronic address: kstevanovic@health.usf.edu.
[Ti] Title:Disruption of normal circadian clock function in a mouse model of tauopathy.
[So] Source:Exp Neurol;294:58-67, 2017 08.
[Is] ISSN:1090-2430
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Disruption of normal circadian rhythm physiology is associated with neurodegenerative disease, which can lead to symptoms such as altered sleep cycles. In Alzheimer's disease (AD), circadian dysfunction has been attributed to ß-amyloidosis. However, it is unclear whether tauopathy, another AD-associated neuropathology, can disrupt the circadian clock. We have evaluated the status of the circadian clock in a mouse model of tauopathy (Tg4510). Tg4510 mice display a long free-running period at an age when tauopathy is present, and show evidence of tauopathy in the suprachiasmatic nucleus (SCN) of the hypothalamus - the site of the master circadian clock. Additionally, cyclic expression of the core clock protein PER2 is disrupted in the hypothalamus of Tg4510 mice. Finally, disruption of the cyclic expression of PER2 and BMAL1, another core circadian clock protein, is evident in the Tg4510 hippocampus. These results demonstrate that tauopathy disrupts normal circadian clock function both at the behavioral and molecular levels, which may be attributed to the tauopathy-induced neuropathology in the SCN. Furthermore, these results establish the Tg4510 mouse line as a model to study how tauopathy disrupts normal circadian rhythm biology.
[Mh] MeSH terms primary: Chronobiology Disorders/etiology
Tauopathies/complications
[Mh] MeSH terms secundary: ARNTL Transcription Factors/genetics
ARNTL Transcription Factors/metabolism
Analysis of Variance
Animals
Chronobiology Disorders/genetics
Disease Models, Animal
Gene Expression Regulation/genetics
Locomotion/genetics
Mice
Mice, Transgenic
Mutation/genetics
Period Circadian Proteins/genetics
Period Circadian Proteins/metabolism
Phosphorylation/genetics
Suprachiasmatic Nucleus/metabolism
Suprachiasmatic Nucleus/pathology
Tauopathies/genetics
Tauopathies/pathology
tau Proteins/genetics
tau Proteins/metabolism
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (ARNTL Transcription Factors); 0 (Arntl protein, mouse); 0 (Per2 protein, mouse); 0 (Period Circadian Proteins); 0 (tau Proteins)
[Em] Entry month:1708
[Cu] Class update date: 180218
[Lr] Last revision date:180218
[Js] Journal subset:IM
[Da] Date of entry for processing:170503
[St] Status:MEDLINE

  2 / 1375 MEDLINE  
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[PMID]: 28463712
[Au] Autor:Au J; Reece J
[Ad] Address:School of Psychological Sciences, Australian College of Applied Psychology, Sydney, Australia. Electronic address: jackyau11@gmail.com.
[Ti] Title:The relationship between chronotype and depressive symptoms: A meta-analysis.
[So] Source:J Affect Disord;218:93-104, 2017 Aug 15.
[Is] ISSN:1573-2517
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:BACKGROUND: Expanding our understanding of the factors that influence depression is crucial for prognosis and treatment. In light of increasing evidence of an association between disrupted circadian rhythms and affective symptoms, a meta-analysis was used to examine the relationship between an eveningness chronotype and depression. METHODS: Electronic searches of the PsycINFO, Medline, Scopus, and Google Scholar databases were conducted in February 2016. Relevant reviews, related journals, and reference lists were manually searched. Statistical data were reported or transformed to a Fisher's z correlational coefficient for effect size analysis. RESULTS: Data from 36 studies (n =15734) met the inclusion criteria and were analysed under a random effects model. Nearly all included studies utilised the Composite Scale of Morningness (CSM) or the Morningness-Eveningness Questionnaire (MEQ) as a measure of chronotype. Overall effect size from 58 effect sizes was small (z=-.20; 95% CI: -.18 to -.23). Effect sizes based on the CSM were significantly larger than those based on the MEQ. There was no evidence of publication bias. LIMITATIONS: The number of studies comparing different mood disorders or the potential moderating effects of gender and age were too few to draw conclusions regarding their respective effect sizes. Future research should utilise longitudinal designs to draw causal inferences on the directionality of this relationship. CONCLUSIONS: Findings from this meta-analysis indicate an eveningness orientation is somewhat associated with more severe mood symptoms. Chronobiological approaches may contribute to the prevention and treatment of depressive disorders.
[Mh] MeSH terms primary: Chronobiology Disorders/psychology
Circadian Rhythm/physiology
Depression/physiopathology
Depression/psychology
Mood Disorders/physiopathology
[Mh] MeSH terms secundary: Adult
Affect/physiology
Chronobiology Disorders/physiopathology
Female
Humans
Male
Middle Aged
Mood Disorders/psychology
Risk Factors
Surveys and Questionnaires
[Pt] Publication type:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Entry month:1802
[Cu] Class update date: 180214
[Lr] Last revision date:180214
[Js] Journal subset:IM
[Da] Date of entry for processing:170503
[St] Status:MEDLINE

  3 / 1375 MEDLINE  
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[PMID]: 29244929
[Au] Autor:Osikov MV; Ogneva OI
[Ti] Title:Relationship between the change of ethological status and concentration of certain cytokines in blood in experimental desynchronosis under led lighting.
[So] Source:Patol Fiziol Eksp Ter;60(4):93-100, 2016 Oct-Dec.
[Is] ISSN:0031-2991
[Cp] Country of publication:Russia (Federation)
[La] Language:eng
[Ab] Abstract:Changing the natural rhythm of day and night leads to the development of DS, disruption of coordinated muscular activity, adequate behavioral activity, a decrease of attention in the performance of night work by experts in various fields. Changes ethological status may potentiate or weaken the changes in the indices of immune status, contribute to the formation of allostatic load at desynchronosis. The purpose: To investigate the relationship between changes ethological status and concentration of certain cytokines in peripheral blood in experimental desynchronosis under LED lighting. Methods: The study was performed on 158 adult guinea pigs, which were randomly assigned into 2 groups: 1 group- animals in the conditions of standard fixed (12 h light / 12 h dark) LED lighting (SFSDO); 2 group- animals with jet lag in terms of LED lighting (DESSDO). Light desynchronosis created by keeping animals at clock coverage for 30 days. Behavioral activity was studied in the test «open field¼ cognitive function was assessed using aqueous «labyrinth¼ Morris. By ELISA was determined on the apparatus in the peripheral blood concentration of interleukin - 4 (IL-4), interferon-gamma (IFN-g), melatonin, cortisol via specific for guinea pig test systems. Results: It was found that in animals of DS in terms of LED lighting in the dynamics of 10-30 days of observation show signs of anxiety, depression orienting-exploratory behavior, reduce the long-term memory and learning ability, spatial orientation disorders. It found that when a jet lag LED lighting conditions for 10 days, 20 days and 30 days in peripheral blood melatonin concentration decreases, the concentration of cortisol rises. In peripheral blood decreased IL-4 concentrations of 20 and 30 days, reducing the concentration of IFN-g at 30 days. Based on the results of correlation analysis, ethological change status and progress of cognitive function with a decrease in the blood concentration of IL-4 and IFN-g, the concentration of melatonin increase cortisol levels. Conclusion: The results indicate that in experimental conditions in desynchronosis LED lighting changes ethological status are associated with the progression of immune status changes.
[Mh] MeSH terms primary: Chronobiology Disorders/blood
Interferon-gamma/blood
Interleukin-4/blood
Lighting
[Mh] MeSH terms secundary: Animals
Chronobiology Disorders/physiopathology
Guinea Pigs
Male
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:207137-56-2 (Interleukin-4); 82115-62-6 (Interferon-gamma)
[Em] Entry month:1801
[Cu] Class update date: 180118
[Lr] Last revision date:180118
[Js] Journal subset:IM
[Da] Date of entry for processing:171216
[St] Status:MEDLINE

  4 / 1375 MEDLINE  
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[PMID]: 29283309
[Au] Autor:Park JW; Cho SJ; Park SG; Chu MK
[Ad] Address:a Department of Neurology , The Catholic University of Korea College of Medicine , Seoul , Korea.
[Ti] Title:Circadian variations in the clinical presentation of headaches among migraineurs: A study using a smartphone headache diary.
[So] Source:Chronobiol Int;:1-9, 2017 Dec 28.
[Is] ISSN:1525-6073
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Migraines occur within certain time frames. Nevertheless, information regarding circadian variation in the clinical presentation of migraine is limited. We investigated circadian variations in the clinical presentation of migraine using a smartphone headache diary (SHD). We enrolled adult participants with the diagnosis of migraine according to the third beta edition of the International Classification of Headache Disorders. Participants were asked to log in to the SHD every day for 90 days to record the occurrence of headaches. We compared the occurrence and clinical presentation of headaches during four 6-hour quadrants per day (00:00-05:59, 06:00-11:59, 12:00-17:59, and 18:00-23:59). Migraine-type headache was defined as a headache attack that fulfilled all criteria of migraine, except for the criterion regarding typical headache duration. Eighty-two participants kept a dairy for at least 50% of the study period and recorded 1491 headache attacks. Among the 1491 headache attacks, 474 (31.8%) were classified as migraine-type headaches and 1017 (68.2%) were classified as non-migraine-type headaches. All headaches, migraine-type headaches and non-migraine-type headaches occurred most frequently between 06:00 and 11:59, and least frequently between 18:00 and 23:59, and between 00:00 and 05:59. Migrainous headache characteristics, such as unilateral pain, pulsating quality, severe headache intensity, aggravation by movement, nausea, photophobia, and phonophobia presented most frequently between 06:00 and 11:59, and least frequently between 18:00 and 23:59, and 00:00 and 05:59 among 1491 all headache attacks. Headache clinical presentation as well as headache occurrence exhibited circadian periodicity among migraineurs. ABBREVIATIONS: SHD: smartphone headache diary; ICHD-3 beta: the third edition beta version of the International Classification of Headache Disorders.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171228
[Lr] Last revision date:171228
[St] Status:Publisher
[do] DOI:10.1080/07420528.2017.1420076

  5 / 1375 MEDLINE  
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[PMID]: 29282999
[Au] Autor:Müller MJ; Haag A
[Ad] Address:1 Oberberg Clinic Group, Clinics for Psychiatry, Psychosomatics and Psychotherapy, Oberberg Kliniken, Berlin, Germany.
[Ti] Title:The concept of chronotypes and its clinical importance for depressive disorders.
[So] Source:Int J Psychiatry Med;:91217417749787, 2017 Jan 01.
[Is] ISSN:1541-3527
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Chronobiology and chronobiological research deal with time-dependent physiological processes and behavioral correlates as well as their adaptation to environmental conditions. Chronobiological research is presently focused on the impact of circadian rhythms on human behavior. In the last three decades, chronobiology has established itself as an independent area of research evolving to an important field of clinical psychology and psychiatry. In this overview, the results of studies on the clinical importance of chronotypes are summarized. The main focus is on the role of chronotype in depressive disorders.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171228
[Lr] Last revision date:171228
[St] Status:Publisher
[do] DOI:10.1177/0091217417749787

  6 / 1375 MEDLINE  
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[PMID]: 29235907
[Au] Autor:de Zambotti M; Goldstone A; Claudatos S; Colrain IM; Baker FC
[Ad] Address:a Center for Health Sciences, SRI International , Menlo Park , CA , USA.
[Ti] Title:A validation study of Fitbit Charge 2™ compared with polysomnography in adults.
[So] Source:Chronobiol Int;:1-12, 2017 Dec 13.
[Is] ISSN:1525-6073
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:We evaluated the performance of a consumer multi-sensory wristband (Fitbit Charge 2™), against polysomnography (PSG) in measuring sleep/wake state and sleep stage composition in healthy adults. In-lab PSG and Fitbit Charge 2™ data were obtained from a single overnight recording at the SRI Human Sleep Research Laboratory in 44 adults (19-61 years; 26 women; 25 Caucasian). Participants were screened to be free from mental and medical conditions. Presence of sleep disorders was evaluated with clinical PSG. PSG findings indicated periodic limb movement of sleep (PLMS, > 15/h) in nine participants, who were analyzed separately from the main group (n = 35). PSG and Fitbit Charge 2™ sleep data were compared using paired t-tests, Bland-Altman plots, and epoch-by-epoch (EBE) analysis. In the main group, Fitbit Charge 2™ showed 0.96 sensitivity (accuracy to detect sleep), 0.61 specificity (accuracy to detect wake), 0.81 accuracy in detecting N1+N2 sleep ("light sleep"), 0.49 accuracy in detecting N3 sleep ("deep sleep"), and 0.74 accuracy in detecting rapid-eye-movement (REM) sleep. Fitbit Charge 2™ significantly (p < 0.05) overestimated PSG TST by 9 min, N1+N2 sleep by 34 min, and underestimated PSG SOL by 4 min and N3 sleep by 24 min. PSG and Fitbit Charge 2™ outcomes did not differ for WASO and time spent in REM sleep. No more than two participants fell outside the Bland-Altman agreement limits for all sleep measures. Fitbit Charge 2™ correctly identified 82% of PSG-defined non-REM-REM sleep cycles across the night. Similar outcomes were found for the PLMS group. Fitbit Charge 2™ shows promise in detecting sleep-wake states and sleep stage composition relative to gold standard PSG, particularly in the estimation of REM sleep, but with limitations in N3 detection. Fitbit Charge 2™ accuracy and reliability need to be further investigated in different settings (at-home, multiple nights) and in different populations in which sleep composition is known to vary (adolescents, elderly, patients with sleep disorders).
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171213
[Lr] Last revision date:171213
[St] Status:Publisher
[do] DOI:10.1080/07420528.2017.1413578

  7 / 1375 MEDLINE  
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[PMID]: 29215920
[Au] Autor:Yang SY; Baek JH; Cho Y; Cho EY; Choi Y; Kim Y; Park T; Hong KS
[Ad] Address:a Department of Psychiatry , Sungkyunkwan University School of Medicine, Samsung Medical Center , Seoul , Korea.
[Ti] Title:Effects of genetic variants of ST8SIA2 and NCAM1 genes on seasonal mood changes and circadian preference in the general population.
[So] Source:Chronobiol Int;:1-11, 2017 Dec 07.
[Is] ISSN:1525-6073
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:ST8SIA2 and NCAM1 are functionally related genes forming polysialic acid (PSA) - neural cell adhesion molecule (NCAM) complex in suprachiasmatic nucleus (SCN), the regulating site of circadian biological rhythm. In this study, the relationship of ST8SIA2 and NCAM1 with circadian and seasonal rhythms of human behavior was explored. Subjects were 261 healthy Korean adults who were free of any history of clinically significant psychiatric symptoms. The phenotypes were circadian preference and seasonal change of mood and behavior (seasonality) measured by the Composite Scale of Morningness and the Seasonal Pattern Assessment Questionnaire, respectively. Thirty-four single nucleotide polymorphisms (SNPs) across the ST8SIA2 region and 15 SNPs of NCAM1 were analyzed. A nominally significant association with seasonality and circadian preference was observed in 21 variants of both genes. After corrections for multiple testing, associations of 8 SNPs of ST8SIA2 and 2 SNPs of NCAM1 with seasonality remained significant. Some of these SNPs were also associated with psychiatric disorders in previous studies. This study demonstrated a meaningful and/or suggestive evidence of association between behavioral phenotypes reflecting human biological rhythm and two interplaying genes involved in the plasticity of SCN's neuronal network.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171207
[Lr] Last revision date:171207
[St] Status:Publisher
[do] DOI:10.1080/07420528.2017.1410827

  8 / 1375 MEDLINE  
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[PMID]: 29157012
[Au] Autor:Kerkhof GA
[Ad] Address:a Department of Psychology , University of Amsterdam , Amsterdam , The Netherlands.
[Ti] Title:Shift work and sleep disorder comorbidity tend to go hand in hand.
[So] Source:Chronobiol Int;:1-10, 2017 Nov 20.
[Is] ISSN:1525-6073
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Taking into consideration that shift work has a wide-ranging impact on circadian and sleep functioning, it seems likely that shift work increases the risk of a general sleep disturbance, spread out over a multitude of comorbid sleep disorders. The aim of the present study is to analyze and present the sleep disorder data of 250 shift workers and 971 permanent day workers, taken from a nationally representative sample. Additional data concerning duration, timing, and quality of sleep, daytime functioning and social/family variables were added to the analyses. The results showed that the shift workers experienced significantly more difficulties with the variability of their sleep times, reported more napping and considered themselves more as poor sleepers than the day workers. Most importantly, shift work, in comparison with day work, appeared associated with a significantly higher prevalence of the clinical, International Classification of Sleep Disorders' defined symptoms of nearly all main sleep disorders (including shift work disorder). For shift workers, the prevalence of a general sleep disturbance was 39.0% (95%CI 33.2 - 45.2), significantly higher than for day workers (24.6%, 95%CI 22.0 - 27.4). Moreover, shift workers were characterized by high levels of sleep disorder comorbidity. In addition, exclusively for shift workers, the prevalence of disordered sleep systematically decreased across decades of life and was considerably higher for single versus partnered shift workers. This study adds to the insight into the interacting factors that determine shift work coping and may play a role in occupational health interventions aimed at reducing sleep problems and thus improving the resilience and tolerance of the shift worker.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171121
[Lr] Last revision date:171121
[St] Status:Publisher
[do] DOI:10.1080/07420528.2017.1392552

  9 / 1375 MEDLINE  
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[PMID]: 29157006
[Au] Autor:Oginska H; Mojsa-Kaja J; Mairesse O
[Ad] Address:a Institute of Applied Psychology , Jagiellonian University , Krakow , Poland.
[Ti] Title:Chronotype description: In search of a solid subjective amplitude scale.
[So] Source:Chronobiol Int;:1-13, 2017 Nov 20.
[Is] ISSN:1525-6073
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The term "subjective circadian amplitude" refers to the range or the distinctness of diurnal variations of arousal, that is, the awareness (or lack thereof) of difference between hyper- and hypo-activation phases, the ability to volitionally modulate one's own psychophysiological state, the strength of morning-evening preferences and flexibility of the rhythm or perceived stability of the circadian phase. The complexity of this construct is the source of difficulties in research and measurement. The psychometric features of distinctness subscales of the Chronotype Questionnaire and the Caen Chronotype Questionnaire are not satisfactory. In search of the solid subjective amplitude (AM) scale, the Rasch analysis was applied to test 12 behavioral descriptors of circadian rhythm distinctness. The results of the Rasch factor analysis showed unidimensionality of the construct. Rating scale diagnostics of the subjective amplitude scale indicated good fit. However, answer category 3 (neutral agreement on the Likert-type, five-point scale) never emerged as modal and step calibrations negated the monotone incrementality of the scale. Rescoring the scale into a four-point category measure yielded satisfactory OUTFIT indices ranging from 0.90 to 1.10. The newly designed AM scale comprised four items referring to small and four to the large amplitude. The four-point answer option was adopted. The data from 234 subjects (53% women; mean age 31.63 ± 12.99 years) were gathered and analyzed. Percent of the total variance explained in Component Analysis (PCA) reached 45.7% (morningness-eveningness (ME) scale - 26.5%, AM scale - 19.2%). There was no correlation between ME and AM scales (Pearsons's simple correlation coefficient r = -0.018). The internal reliability of the AM scale, as measured with Cronbach's alpha coefficient, proved to be satisfactory: 0.72 (for ME scale - 0.86). Item-total correlations in the AM scale ranged from 0.433 to 0.774 and were significant at p < 0.001. Confirmatory factorial analysis of AM scale indicated mediocre fit: chi-square/degree of freedom = 3.00, root mean square error of approximation = 0.09, standardized root mean square residual = 0.08, comparative fit index = 0.87, Tucker-Lewis index = 0.82. However, the results of Rasch analysis showed good fit statistics for all items: OUTFIT mean squares range from 0.63 to 1.34 and INFIT mean square range from 0.64 to 1.40. All observed values were ≤1.4, which confirmed the new scale as being unidimensional.f If to consider the chronotype in the context of the classical Borbely's two-process model of sleep regulation, it may be assumed that ME dimension relates to the tempo of increasing of sleep pressure during the day, that is, it reflects the homeostatic component of the diurnal rhythm of sleepiness. As to the amplitude, it may be supposed that more distinct rhythm (large amplitude) stands for greater vulnerability to the time of day - it resounds the circadian component of the sleep proneness. It seems that distinct diurnal changes of arousal indicate emotional lability and may be associated with emotional responsiveness, which in turn manifests itself in a characteristic style of coping with stressful situations. One may therefore consider the diurnal variability of arousal as a factor increasing individual susceptibility to mood swings and affective disorders.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171121
[Lr] Last revision date:171121
[St] Status:Publisher
[do] DOI:10.1080/07420528.2017.1372469

  10 / 1375 MEDLINE  
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[PMID]: 29144185
[Au] Autor:Roveda E; Montaruli A; Galasso L; Pesenti C; Bruno E; Pasanisi P; Cortellini M; Rampichini S; Erzegovesi S; Caumo A; Esposito F
[Ad] Address:a Department of Biomedical Sciences for Health , University of Milan , Milan , Italy.
[Ti] Title:Rest-activity circadian rhythm and sleep quality in patients with binge eating disorder.
[So] Source:Chronobiol Int;:1-10, 2017 Nov 16.
[Is] ISSN:1525-6073
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Recent findings suggest that altered rest-activity circadian rhythms (RARs) are associated with a compromised health status. RARs abnormalities have been observed also in several pathological conditions, such as cardiovascular, neurological, and cancer diseases. Binge eating disorder (BED) is the most common eating disorder, with a prevalence of 3.5% in women and 2% in men. BED and its associate obesity and motor inactivity could induce RARs disruption and have negative consequences on health-related quality of life. However, the circadian RARs and sleep behavior in patients with BED has been so far assessed only by questionnaires. Therefore, the purpose of this study was to determine RARs and sleep parameters by actigraphy in patients with BED compared to a body mass index-matched control group (Ctrl). Sixteen participants (eight obese women with and eight obese women without BED diagnosis) were recruited to undergo 5-day monitoring period by actigraphy (MotionWatch 8®, CamNtech, Cambridge, UK) to evaluate RARs and sleep parameters. In order to determine the RARs, the actigraphic data were analyzed using the single cosinor method. The rhythmometric parameters of activity levels (MESOR, amplitude and acrophase) were then processed with the population mean cosinor. The Actiwatch Sleep Analysis Software (Cambridge Neurotecnology, Cambridge, UK) evaluated the sleep patterns. In each participant, we considered seven sleep parameters (sleep onset: S-on; sleep offset: S-off; sleep duration: SD; sleep latency: SL; movement and fragmentation index: MFI; immobility time: IT; sleep efficiency: SE) calculated over a period of five nights. The population mean cosinor applied to BED and Ctrl revealed the presence of a significant circadian rhythm in both groups (p < 0.001). The MESOR (170.0 vs 301.6 a.c., in BED and Ctrl, respectively; p < 0.01) and amplitude (157.66 vs 238.19 a.c., in BED and Ctrl, respectively p < 0.05) differed significantly between the two groups. Acrophase was not different between BED and Ctrl, as well as all sleep parameters. Both groups displayed a low level of sleep quality (SE 80.7% and 75.7% in BED and Ctrl, respectively). These data provided the first actigraphy-based evidence of RARs disruption and sleep behavior disorder in patients with BED. However, while sleep disorders could be reasonably ascribed to overweight/obesity and the related lower daily physical activity, RARs disruption in this pathology should be ascribed to factors other than reduced physical activity. The circadian timing approach can represent a novel potential tool in the treatment of patients with eating disorders. These data provide exploratory evidence of behavioral association in a small population of patients that, if confirmed in a wider number of subjects and across different populations, may lead to a revision and enhancement of interventions in BED patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171116
[Lr] Last revision date:171116
[St] Status:Publisher
[do] DOI:10.1080/07420528.2017.1392549


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